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See detailRGDS and DGEA-induced [Ca2+]i signalling in human dermal fibroblasts.
Mineur, Pierre ULg; Guignandon, A.; Lambert, Charles ULg et al

in Biochimica et Biophysica Acta (2005), 1746(1), 28-37

A pulse of short peptides, RGDS and DGEA in the millimolar range, immediately elicits in normal human fibroblasts a transient increase of intracellular Ca2+ ([Ca2+]i). In the present study, we show that ... [more ▼]

A pulse of short peptides, RGDS and DGEA in the millimolar range, immediately elicits in normal human fibroblasts a transient increase of intracellular Ca2+ ([Ca2+]i). In the present study, we show that this [Ca2+]i occurs in an increasing number of cells as a function of peptides concentration. It is specific of each peptide and inhibited at saturating concentration of the peptide in the culture medium. The [Ca2+]i transient depends on signalling pathways slightly different for DGEA and RGDS involving tyrosine kinase(s) and phosphatase(s), phospholipase C, production of inositol-trisphosphate and release of Ca2+ from the cellular stores. GFOGER, the classical collagen binding peptide of alpha1- alpha2- and alpha11-beta1 integrins, in triple helical or denatured form, does not produce any Ca2+ signal. The [Ca2+]i signalling induced by RGDS and DGEA is inhibited by antibodies against beta1 integrin subunit while that mediated by RGDS is also inhibited by antibodies against the alpha3 integrin. Delay in the acquisition of responsiveness is observed during cell adhesion and spreading on a coat of fibronectin for RGDS or collagen for DGEA or on a coat of the specific integrin-inhibiting antibodies but not by seeding cells on GFOGER or laminin-5. This delay is suppressed specifically by collagenase acting on the collagen coat or trypsin on the fibronectin coat. Our results suggest that free integrins and associated focal complexes generate a Ca2+ signal upon recognition of DGEA and RGDS by different cellular pathways. [less ▲]

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See detailPensieri sulla critica della traduzione e sulla sua ricezione
Curreri, Luciano ULg

in Palazzo Sanvitale (2005), 15/16

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See detailA trial of metoclopramide vs sumatriptan for the emergency department treatment of migraines.
Allena, Marta; Magis, Delphine ULg; Schoenen, Jean ULg

in Neurology (2005), 65(8), 1339-401339-40

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See detailMartin pêcheur: oiseau de l'année 2005
Libois, Roland ULg

Learning material (2005)

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See detailLa croix et la bannière : les catholiques en Luxembourg de Rerum Novarum à Vatican II
Donneau, Olivier ULg

Book published by Musée en Piconrue (2005)

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See detailVictor Chauvin (1844-1913) et René Basset (1855-1924): les itinéraires croisés de deux savants
Bauden, Frédéric ULg

in Basset, René; Chraïbi, Aboubakr (Eds.) Mille et un contes. Récits et légendes arabes (2005)

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See detailCompte rendu de Br.Galland, Les authentiques de reliques du Sancta sanctorum
George, Philippe ULg

in Revue d'Histoire Ecclésiastique (2005)

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See detailIconographies de saints mosans : Stuttgart, W. Landesbibliothek Cod. Hist. 2° 415
George, Philippe ULg

in Bulletin de la Société Royale Le Vieux-Liège (2005)

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See detailSelection of antagonists of postharvest apple parasites: penicillium expansum and botrytis cinerea
Achbani, E. H.; Mounir, R.; El Jaafari, S. et al

in Communications in Agricultural and Applied Biological Sciences (2005), 70(3), 143-149

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See detailIncreased topsoil mineral nutrient concentrations under exotic invasive plants in belgium
Vanderhoeven, SONIA ULg; Dassonville, N.; Meerts, P.

in Plant and Soil (2005), 275(1-2), 169-179

Exotic invasive plants can alter ecosystem processes. For the first time in Europe, we have analysed the impacts of exotic invasive plants on topsoil chemical properties. At eight sites invaded by five ... [more ▼]

Exotic invasive plants can alter ecosystem processes. For the first time in Europe, we have analysed the impacts of exotic invasive plants on topsoil chemical properties. At eight sites invaded by five exotic invasive species (Fallopia japonica, Heracleum mantegazzianum, Solidago gigantea, Prunus serotina and Rosa rugosa), soil mineral element composition was compared between invaded patches and adjacent, uninvaded vegetation. We found increased concentrations of exchangeable essential nutrients under the canopy of exotic invasive plants, most strikingly so for K and Mn (32% and 34% increase, respectively). This result fits in well with previous reports of enhanced N dynamics in invaded sites, partly due to higher net primary productivity in exotic invasive plants compared to native vegetation. [less ▲]

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See detailMolecular organization of selected prokaryotic S-Iayer proteins
Claus, Harald; Akça, Erol; Debaerdemaeker, Tony et al

in Canadian Journal of Microbiology (2005), 51

Regular crystalline surface layers (S-layers) are widespread among prokaryotes and probably represent the earliest cell wall structures. S-layer genes have been found in approximately 400 different ... [more ▼]

Regular crystalline surface layers (S-layers) are widespread among prokaryotes and probably represent the earliest cell wall structures. S-layer genes have been found in approximately 400 different species of the prokaryotic domains bacteria and archaea. S-layers usually consist of a single (glyco-rprotein species with molecular masses ranging from about 40 to 200 kDa that form lattices of oblique, tetragonal, or hexagonal architecture. The primary sequences of hyperthermophilic archaeal species exhibit some characteristic signatures, Further adaptations to their specific environments occur by various post-translational modifications, such as linkage of glycans, lipids, phosphate, and sulfate groups to the protein or by proteolytic processing. Specific domains direct the anchoring of the S-layer to the underlying cell wall components and transport across the cytoplasma memhrane. In addition to their presumptive original role as protective coats in archaea and bacteria, they have adapted new functions, e.g., as molecular sieves, attachment sites for extracellular enzymes, and virulence factors. [less ▲]

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See detailIrregular earthquake cycle along the southern Tianshan front, China (Aksu area)
Hubert, Aurelia ULg; Suppe, J.; Van Der Woerd, J. et al

in Journal of Geophysical Research (2005), 110(10.1029/2003JB002603),

A long deformation record (􏰩16.5 ka) showing nonsteady earthquake recurrence is established for the Aksu thrust (Tianshan, China) on the basis of cosmogenic 10Be dating of faulted surfaces. Topographic ... [more ▼]

A long deformation record (􏰩16.5 ka) showing nonsteady earthquake recurrence is established for the Aksu thrust (Tianshan, China) on the basis of cosmogenic 10Be dating of faulted surfaces. Topographic leveling across the Aksu fault scarp indicates up to 􏰩10 m uplift across a moraine abandoned 􏰩16.5 ka and similar uplift of 􏰩6 m across two inset surfaces yielding ages of 􏰩12.5 and 􏰩5 ka. Successively smaller uplifts of terraces younger than 5 ka indicate that three or more major earthquakes occurred during this period. These data show that the Aksu thrust fault was quiet for at least 7500 years and active in the last 􏰩5000 years and probably in the interval 16.5–12.5 ka. The seismic cycle along the Aksu thrust fault over the last 􏰩16,500 years was thus strongly irregular showing long quiescence and clustering, which is a challenge for paleoseismology and hazard assessment. This irregularity also makes it more difficult to estimate long-term shortening rates. Nevertheless, we are able to constrain a minimum total shortening rate (>7 mm/yr) across the southern Tianshan front for the last 12,500 years that is about a third of the total geodetic rate for the western Tianshan (􏰩20 mm/yr). [less ▲]

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See detailHistorique du parcde Cointe (Liège)
Frankignoulle, Pierre ULg; De Harlez, Nathalie; Delloue, Sylvie

Report (2005)

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See detailTrophoblast Invasion and Placentation: Molecular Mechanisms and Regulation
van den Brule, F.; Berndt, Sarah ULg; Simon, N. et al

in Chemical Immunology and Allergy (2005), 88

Trophoblast invasion is a key process during human placentation. This event constitutes the basis of the conversion of the uterine spiral arteries, a process which allows an adequate vascular connection ... [more ▼]

Trophoblast invasion is a key process during human placentation. This event constitutes the basis of the conversion of the uterine spiral arteries, a process which allows an adequate vascular connection between the intervillous space and the maternal blood flow. Trophoblast invasion is transient, with stringent spatial and temporal control. Preeclampsia, a leading cause of maternal and fetal mortality and morbidity, is associated with decreased, shallow trophoblastic invasion. In this article, we review the molecular mechanisms of trophoblast invasion, and its mechanisms of regulation. Insights into the etiopathogenesis of preeclampsia will also be detailed. [less ▲]

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See detailPrimary temporal bone angiosarcoma: a case report.
Scholsem, Martin; Raket, Daniel; Flandroy, Pierre et al

in Journal of neuro-oncology (2005), 75(2), 121-5

We present a rare case of temporal bone angiosarcoma diagnosed in a 26-year-old female patient at 36 week of pregnancy. The patient was referred with a 2 months history of left otalgia and tinnitus with a ... [more ▼]

We present a rare case of temporal bone angiosarcoma diagnosed in a 26-year-old female patient at 36 week of pregnancy. The patient was referred with a 2 months history of left otalgia and tinnitus with a tender swelling above the mastoid. Cranial imaging studies showed a 7 x 5 x 4 cm hypervascularized mass located in the left middle fossa with lysis of the temporal bone and extension to the subcutis. After the baby was delivered by caesarean section, the patient entered the oncology protocol. Selective embolization of the feeding vessels was followed by gross total surgical resection using a combined supra- and infra-tentorial approach. Pathological findings were those of a poorly differentiated, highly malignant sarcoma with a large epitheloid component and immunohistochemical evidence of endothelial differentiation (CD31, Factor VIII related antigen, CD34), consistent with an angiosarcoma with epitheloid features. No extra-cranial tumor was found after extensive staging. The patient received adjuvant radiotherapy followed by a course of chemotherapy consisting of 6 cycles of paclitaxel. At 15 months follow-up, she developed multiple distant metastasis to a left postauricular lymph node and to the lungs and ribs. The patient was given a second line chemotherapy using doxorubicine and ifosfamide. Despite an initial good response, she died with metastatic disease 26 months after diagnosis. We present a rare case of primary temporal bone angiosarcoma and report our experience with a multimode therapeutic approach combining surgery, radiotherapy and chemotherapy. [less ▲]

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See detailL’apoptose du neutrophile
Fievez, Laurence ULg; Seumois, G.; Lekeux, Pierre ULg et al

in Annales de Médecine Vétérinaire (2005), 149

Regulation of the neutrophil life span by apoptosis provides a fine balance between their function as effector cells of host defence and a safe turnover of these potentially harmful cells. Apoptosis is ... [more ▼]

Regulation of the neutrophil life span by apoptosis provides a fine balance between their function as effector cells of host defence and a safe turnover of these potentially harmful cells. Apoptosis is thus necessary to keep cellular homeostasis under physiologic conditions. Alterations of neutrophil apoptosis are associated with diseases such as bacterial and autoimmune inflammatory diseases where neutrophil apoptosis is delayed. Excessive production of survival factors is often observed in such inflammatory responses and neutrophil survival can be increased several fold. Cytokines withdrawal, as it occurs in the resolution phase of inflammation, leads to the induction of neutrophil apoptosis. Recent studies have shown the involvement of members of the Bcl-2 protein family and caspases in the regulation and execution of neutrophil apoptosis. Cell surface receptors and protein kinases also play critical roles in transducing the signals that result in neutrophil apoptosis or extended survival. The aim of this review is to summarise the principal molecular mechanisms and components of neutrophil apoptosis [less ▲]

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See detailImpact physiologique et pathologique du stress oxydant chez le cheval
De Moffarts, Brieuc; Kirschvink, Nathalie; Pincemail, Joël ULg et al

in Annales de Médecine Vétérinaire (2005), 149(1), 1-9

Oxidative stress has become of increasing interest in research and in equine and human medicine. If the pro-oxidant burden overwhelms the endogenous antioxidant defence of the organism, the arising ... [more ▼]

Oxidative stress has become of increasing interest in research and in equine and human medicine. If the pro-oxidant burden overwhelms the endogenous antioxidant defence of the organism, the arising imbalance between pro- and antioxidants is defined as oxidative stress. Different pathways might increase the generation of reactive oxygen species ( ROS) and results in oxidative stress. In physiological conditions, like during moderated exercise, the balance between ROS production and antioxidants allows to maintain an optimal organic function. In the light of the potentially deleterious role of excessive ROS production and the evidence that exercise-induced oxidative stress occurs in horses, the assessment of the antioxidant status should be considered in sport horses. Recent researches indicate that oxidative stress may play a role in physiopathology of several pathological syndromes in horses. Therefore, with classical treatment, the controlled administration of antioxidants appears interesting for the modulation of these processes, as well as in sport horses during intense exercise period. [less ▲]

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See detailPrincipes des microdamiers à ADN et applications potentielles en sciences vétérinaires
Thomas, A.; Closset, Jean ULg; Bureau, Fabrice ULg et al

in Annales de Médecine Vétérinaire (2005), 149

Microarray technology is a miniaturized biotechnological tool with potential applications for study and analysis of multiple molecular compounds as proteins, lipids, carbohydrates or nucleic acids. The ... [more ▼]

Microarray technology is a miniaturized biotechnological tool with potential applications for study and analysis of multiple molecular compounds as proteins, lipids, carbohydrates or nucleic acids. The nucleic acids microarray technology focuses interest of scientists for fifteen years because of its huge potential as regard to the scientific research, clinical diagnosis, and development of new drugs. Only DNA microarrays are investigated in this paper. Born from the conjunction of micro-electronics, biochemistry, molecular biology, and image processing, microarrays allow to analyse several thousands of genetic information simultaneously. Thanks to this new tool, it is possible in parallel to identify, to even proportion, a considerable number of nucleic acid sequences contained in a biological sample (blood, biopsy, water, food, etc). This article proposes, after having considered the operating mode of the microarrays, to understand their quality standards as well as their advantages and disadvantages. The two following parts are devoted to the place the microarrays occupy in scientific research and in the establishment of a clinical diagnosis. Finally the last part evaluates prospects the microarrays offer in veterinary sciences. [less ▲]

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See detailEvocation d'une expérience d'enseignement: « Architecture paramétrable et architecture fractale, génération numérique des formes complexes. »
Bianchi, Romuald ULg; Defawes, Georges ULg

in Actes de SCAN'05 : Séminaire de conception architecturale numérique (2005)

cette communication relate l'élaboration d'un cours orienté vers la découverte des formes à géométrie complexe. Le contenu de ce cours, dispensé pour la 1ère fois en mai 2005, a déjà évolué. Il est apparu ... [more ▼]

cette communication relate l'élaboration d'un cours orienté vers la découverte des formes à géométrie complexe. Le contenu de ce cours, dispensé pour la 1ère fois en mai 2005, a déjà évolué. Il est apparu que les outils proposés pour explorer les formes complexes étaient également opérationnels comme outils d'assistance à l'esquisse [less ▲]

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