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See detailPlasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis.
Bajou, Khalid ULg; Peng, H.; Laug, W. E. et al

in Cancer Cell (2008), 14(4), 324-34

Plasminogen activator inhibitor-1 (PAI-1) paradoxically enhances tumor progression and angiogenesis; however, the mechanism supporting this role is not known. Here we provide evidence that PAI-1 is ... [more ▼]

Plasminogen activator inhibitor-1 (PAI-1) paradoxically enhances tumor progression and angiogenesis; however, the mechanism supporting this role is not known. Here we provide evidence that PAI-1 is essential to protect endothelial cells (ECs) from FasL-mediated apoptosis. In the absence of host-derived PAI-1, human neuroblastoma cells implanted in PAI-1-deficient mice form smaller and poorly vascularized tumors containing an increased number of apoptotic ECs. We observed that knockdown of PAI-1 in ECs enhances cell-associated plasmin activity and increases spontaneous apoptosis in vitro. We further demonstrate that plasmin cleaves FasL at Arg144-Lys145, releasing a soluble proapoptotic FasL fragment from the surface of ECs. The data provide a mechanism explaining the proangiogenic activity of PAI-1. [less ▲]

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See detailMatrix metalloproteinases at cancer tumor-host interface
Noël, Agnès ULg; Jost, M.; Maquoi, Erik ULg

in Seminars in Cell & Developmental Biology (2008), 19

The increasing diversity in both substrates and functions of matrix metalloproteinases (MMPs) makes these enzymes central regulators in the complex tumor ecosystem composed of cancer cells and their ... [more ▼]

The increasing diversity in both substrates and functions of matrix metalloproteinases (MMPs) makes these enzymes central regulators in the complex tumor ecosystem composed of cancer cells and their microenvironment. In the majority of cancers, membrane-associated and extracellular proteases are mainly produced by host cells including inflammatory cells, endothelial cells, pericytes and fibroblasts. Recent data based on in vitro and in vivo studies have demonstrated the relevance of these enzymes in multiple processes controlling cancer growth, angiogenesis and metastatic dissemination. This review will present the emerging MMP-related features of cancer cells and host cells. [less ▲]

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See detailLes Monts de Baileux section: detailed sedimentology and magnetic susceptibility of Hanonet, Trois-Fontaines and Terres d'Haurs formations (Eifelian-Givetian boundary and Lower Givetian, SW Belgium)
Mabille, Cédric ULg; Boulvain, Frédéric ULg

in Geologica Belgica (2008), 11

This work details for the first time the sedimentology of Les Monts de Baileux section. This section, located in a quarry between Chimay and Couvin, exposes a remarkable succession of strata from the top ... [more ▼]

This work details for the first time the sedimentology of Les Monts de Baileux section. This section, located in a quarry between Chimay and Couvin, exposes a remarkable succession of strata from the top of the Jemelle Formation to the base of the Mont d’Haurs Formation. It therefore offers the opportunity to investigate the entire Hanonet, Trois- Fontaines and Terres d’Haurs formations, biostratigraphically from Polygnathus ensensis to P. timorensis conodont zones. This large lithostratigraphic thickness of clayley and argillaceous, and also pure limestones encompasses the Eifelian/ Givetian boundary in the lower part of Hanonet Formation, allowing a better understanding of the transition between the Eifelian which corresponds to a mixed siliciclastic-carbonate detrital ramp and the lower Givetian dominated by a carbonate rimmed shelf-related sedimentation. Petrographic study leads to the definition of 21 microfacies integrated into two palaeogeographical models. The first model (13 microfacies) is proposed for the Jemelle, Hanonet and Trois-Fontaines formations, i.e. P. ensensis Zone and almost entire P. hemiansatus Zone. In this platform model, the fore-reef environment is characterized by a high influence of storm events and carbonate input coming from proximal settings. The reef is mainly composed of an accumulation of stromatoporoids, crinoids, tabulate corals and rugose corals with a peloidal matrix. The back-reef area is dominated by agitated environments and calmer lagoons. Locally, less agitated conditions allow growth of massive and laminar organisms. The second model (6 microfacies) concerns the Terres d’Haurs Formation with the end of P. hemianstus Zone and significant part of the P. timorensis Zone. This ramp model is divided into a mid-ramp characterized by open-marine sedimentation interrupted by storm-related events and an inner ramp composed of ooidal shoals, back-shoal sedimentation and storm related deposits. Two other microfacies are fragmentarily defined for the Mont d’Haurs Formation, within the main P. varcus / P. rhenanus intervals. This unit was affected by strong dolomitization processes, where scarcity of well preserved, primary sedimentary fabrics is not favourable for designing of a microfacies-based model at all. The last part of the work concerns stratigraphic variations of magnetic susceptibility (MS). Values of mass MS of rocks were plotted and juxtaposed with semi-quantitative variation curves of microfacies. According to the prevailing magnitudes of MS, the relationships with two controlling parameters are evaluated: terrigenous influence (using the thin-section data on detrital quartz contents as proxies) and wave agitation (based on microfacies interpretation). The transgressive- regressive evolution of microfacies characteristics are compared with the juxtaposed trends in decreasing-increasing MS magnitudes. Approximately two thirds of this section suggests a good matching of the trends on generalized lithological and magnetic data. It is explained by common presence of clayey/silty impurities of slightly to moderately varying compositions which are greatly evidenced by means of thin-section studies and represent a principal and abundant paramagnetic component. The overall MS magnitudes actually show decreasing trends together with vigorous, eustatically driven sealevel rises. However, the remaining third of intervals in this section shows the rather complex than simple, equivocally or negatively arranged sequence/lithologic and MS stratigraphic trends. [less ▲]

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See detailWaging the War from the Outside: The Writers of the West Indian Diaspora and their Role in the Future of the Caribbean
Ledent, Bénédicte ULg

in Gyssels, Kathleen; Ledent, Bénédicte (Eds.) The Caribbean Writer as Warrior of the Imaginary / L'écrivain caribéen, guerrier de l'imaginaire (2008)

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See detailExploiting tree-based variable importances to selectively identify relevant variables
Huynh-Thu, Vân Anh; Wehenkel, Louis ULg; Geurts, Pierre ULg

in Proc. of FSDM08, ECML/PKDD Workshop on New challenges for feature selection in data mining and knowledge discovery (2008)

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See detailSome suitable grasses and legumes for ley pastures in Sudanian Africa: the case of the Borgou region in Benin.
Adjolohoun, Sébastien; Bindelle, Jérôme ULg; Adandédjan, Claude et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2008), 12(4), 405-419

In Sudanian region of Africa, agricultural systems are under increasing pressure because of human and animal population growth, climate changes, extensive practises, decreasing prices for cash crops, etc ... [more ▼]

In Sudanian region of Africa, agricultural systems are under increasing pressure because of human and animal population growth, climate changes, extensive practises, decreasing prices for cash crops, etc. Possibilities of intensification in smallholder farming systems of the Borgou region in Benin are limited due to difficulties to pay for external inputs. Therefore, rural communities rely heavily on low input technologies to increase crop production and animal feed. Cultivated forages are of better-feed quality for ruminants compared to weed fallows. Their integration in cropping system through ley pastures has the potential to increase not only animal feed availability but also to improve soil fertility. This paper reviews some possible grass and legume species that can be used for that purpose with a special focus on the strengths and weaknesses of the species in terms of soil and climate suitability, forage production, nutritive value and soil fertility restoration. The choice of one or several among them as leys in pure stands or mixed forage crops must be taken carefully considering the balance between advantages and disadvantages of the species, the available financial and technical inputs and the adaptation to the local environment. [less ▲]

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See detailProtinet - chapter 5.4
Malaisse, François ULg; Mathieu, Françoise; Lognay, Georges ULg et al

in Big Bone Disease - A multidisciplinary approach of Kashin-Beck disease in Tibet Autonomous Region (P.R. China) (2008)

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See detailIsokinetic fatigue protocol: Assessment of shoulder rotator muscles
Forthomme; Maquet, Didier ULg; Lehance, Cédric ULg et al

in Abstract book of 13th Annual Congress of the European College of Sport Science (2008)

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See detailComplementary approaches to measure environmental odours emitted by landfill areas
Romain, Anne-Claude ULg; Delva, Julien ULg; Nicolas, Jacques ULg

in Sensors and actuators. B, Chemical (2008), 131(1), 18-23

This paper presents different methods to assess the odour emission and the odour annoyance in the surroundings. It is shown, on the example of landfill areas and composting facilities, that chemical ... [more ▼]

This paper presents different methods to assess the odour emission and the odour annoyance in the surroundings. It is shown, on the example of landfill areas and composting facilities, that chemical analyses are helpful to identify key compounds of the odour release, and to set up the specification of a monitoring instrument. Sensitive methods, like dynamic olfactometry or sniffing team investigation, are mainly applicable to provide a global odour plume or an average annoyance zone. And the electronic nose can supply a warning signal to the plant manager or a real time estimation of the annoyance zone. [less ▲]

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See detailAu-delà du bois : les nombreux enjeux de la foresterie communautaire gabonaise
Vermeulen, Cédric ULg

in Vermeulen, Cédric; Doucet, Jean-Louis (Eds.) Les premières forêts communautaires du Gabon : Récits d'une expérience pilote (2008)

Au-delà des inventaires, des plans simples de gestion et autres aspects techniques, la mise en place des premières forêts communautaires gabonaises est l’objet d’enjeux multiples aux implications parfois ... [more ▼]

Au-delà des inventaires, des plans simples de gestion et autres aspects techniques, la mise en place des premières forêts communautaires gabonaises est l’objet d’enjeux multiples aux implications parfois inattendues : rapport des communautés à l’espace qu’elles occupent, rapport que l’état entretien avec les communautés, question de la représentativité, rapport du secteur privé aux populations locales, enjeux administratifs et fi nanciers, enjeux de genre, enjeux identitaires…La foresterie communautaire apparaît sur le plan social bien plus complexe qu’elle ne le laisse supposer de prime abord. D’emblée, elle questionne l’ensemble de la gestion du secteur forêt. [less ▲]

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See detailPerception of pain in the minimally conscious state with PET activation: an observational study.
Boly, Mélanie ULg; Faymonville, Marie-Elisabeth ULg; Schnakers, Caroline et al

in Lancet Neurology (2008), 7(11), 1013-20

BACKGROUND: Patients in a minimally conscious state (MCS) show restricted self or environment awareness but are unable to communicate consistently and reliably. Therefore, better understanding of cerebral ... [more ▼]

BACKGROUND: Patients in a minimally conscious state (MCS) show restricted self or environment awareness but are unable to communicate consistently and reliably. Therefore, better understanding of cerebral noxious processing in these patients is of clinical, therapeutic, and ethical relevance. METHODS: We studied brain activation induced by bilateral electrical stimulation of the median nerve in five patients in MCS (aged 18-74 years) compared with 15 controls (19-64 years) and 15 patients (19-75 years) in a persistent vegetative state (PVS) with (15)O-radiolabelled water PET. By way of psychophysiological interaction analysis, we also investigated the functional connectivity of the primary somatosensory cortex (S1) in patients and controls. Patients in MCS were scanned 57 (SD 33) days after admission, and patients in PVS 36 (9) days after admission. Stimulation intensities were 8.6 (SD 6.7) mA in patients in MCS, 7.4 (5.9) mA in controls, and 14.2 (8.7) mA in patients in PVS. Significant results were thresholded at p values of less than 0.05 and corrected for multiple comparisons. FINDINGS: In patients in MCS and in controls, noxious stimulation activated the thalamus, S1, and the secondary somatosensory or insular, frontoparietal, and anterior cingulate cortices (known as the pain matrix). No area was less activated in the patients in MCS than in the controls. All areas of the cortical pain matrix showed greater activation in patients in MCS than in those in PVS. Finally, in contrast with patients in PVS, those in MCS had preserved functional connectivity between S1 and a widespread cortical network that includes the frontoparietal associative cortices. INTERPRETATION: Cerebral correlates of pain processing are found in a similar network in controls and patients in MCS but are much more widespread than in patients in PVS. These findings might be objective evidence of a potential pain perception capacity in patients in MCS, which supports the idea that these patients need analgesic treatment. [less ▲]

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See detailRegulation of CD95/APO-1/Fas-induced apoptosis by protein phosphatases.
Gloire, Geoffrey ULg; Charlier, Edith ULg; Piette, Jacques ULg

in Biochemical Pharmacology (2008)

Triggering the CD95/APO-1/Fas receptor by CD95-L induces the assembly of the death-inducing signaling complex (DISC), which permits initiator caspases activation and progression of a signaling cascade ... [more ▼]

Triggering the CD95/APO-1/Fas receptor by CD95-L induces the assembly of the death-inducing signaling complex (DISC), which permits initiator caspases activation and progression of a signaling cascade that culminates in cellular apoptosis. Despite the CD95 receptor does not exhibit any kinase activity by itself, phosphorylation/dephosphorylation events seem important to regulate many aspects of CD95-mediated apoptosis. Here, we try to highlight particularly the importance of protein phosphatases in the modulation of the CD95 system. [less ▲]

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See detailLes enjeux socio-économiques autour de l’agroforesterie villageoise à Aguié (Niger)
Dramé Yayé, A.; Berti, Fabio ULg

in Tropicultura (2008), 26(3), 141-149

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See detailBelgium Cost E33 WG2 Country Report - Recreation and nature tourism demand, supply and actual usage
Colson, Vincent ULg; Van Kerckhove, G.; Vanwijnsberghe, S.

in Sievänen, T.; Arnberger, A.; Dehez, J. (Eds.) et al Forest Recreation Monitoring - a European Perspective (2008)

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See detailChapter 3. State of art of recreation inventories in European countries - 3.1 National recreation demand inventories and surveys
Dehez, J.; Colson, Vincent ULg; Mann, C. et al

in Sievänen, T.; Arnberger, A.; Dehez, J. (Eds.) et al Forest Recreation Monitoring - a European Perspective (2008)

Detailed reference viewed: 52 (6 ULg)