Thyrotropin-Secreting Pituitary Adenomas: Report of Seven Cases

in Journal of Clinical Endocrinology and Metabolism (1991), 72(2), 477-83

Seven patients with hyperthyroidism due to a TSH-secreting pituitary macroadenoma have been observed of a total of 800 patients with pituitary tumors over a period of 15 yr. Serum TSH levels varied ... [more ▼]

Seven patients with hyperthyroidism due to a TSH-secreting pituitary macroadenoma have been observed of a total of 800 patients with pituitary tumors over a period of 15 yr. Serum TSH levels varied between 1.1-36.3 mU/L. The serum alpha-subunit level was low in 1 case, while in 4 other cases the concentration was elevated and varied between 3.7-7.8 micrograms/L. Serum TSH beta levels were normal in the 4 cases in which it was determined. Serum GH or PRL levels were elevated in 5 cases. In 1 patient the cosecretion of TSH, GH, and PRL was confirmed by immunocytochemical examination. Serum TSH and alpha-subunit responses to TRH, GnRH, CRF, GRF, dexamethasone, methimazole, T3, and bromocriptine administration were variable when studied. Serum TSH and alpha-subunit circadian rhythms were absent in 1 case and inverted in another. A serum alpha-subunit pulsatility without TSH pulses was observed in 1 patient. Five patients underwent transsphenoidal adenomectomy. Three of 4 patients operated on in our center were cured, but a recurrence of the adenoma was found in 1 of them after 5 yr. The fifth patient was not cured. Treatment with octreotide in 3 patients resulted in normalization of serum TSH, GH, and thyroid hormones levels. Cosecretion of PRL in 1 case and alpha-subunit in 2 cases was also inhibited. Partial tachyphylaxis occurred in 1 patient. In summary, heterogeneity in clinical presentation, hormonal expression, and therapeutic response appears to characterize these TSH-secreting adenomas. [less ▲]

Rapport de stage (jounalistique)

Report (1991)

Le groupe de Mr C. ROUSSEL fontionne autour de trois grands axes qui sont: - Les synthéses organiques chirales, - Les phases chromatographiques chirales, - Le projet CHIRBASE. Chacun de ces axes n'est pas ... [more ▼]

Le groupe de Mr C. ROUSSEL fontionne autour de trois grands axes qui sont: - Les synthéses organiques chirales, - Les phases chromatographiques chirales, - Le projet CHIRBASE. Chacun de ces axes n'est pas aussi indépendant qu'on pourrait le croire.On voit par exemple des synthéses de thiazolinethiones chirales qui serviront plus tard de phases stationnaires chirales. On constate quand même cette année plus de synthése achirale que de synthése chirale.Mais ceci est un fait exceptionnel. Quand au projet CHIRBASE, véritablement travail de fourmis qui consiste à rassembler le maximum de renseignements sur les séparations en HPLC de molécules chirales (séparation des énantioméres) afin d'être beaucoup plus efficace tout en gagnant du temps. La recherche pour comprendre les interactions entre une phase stationnaire passe par un plan d'expérience développé par le Professeur C. ROUSSEL, afin là aussi d'aller plus vite dans cette compréhension (bientôt sur les cyclodextrines). [less ▲]

Le dosage du récepteur circulant de la transferringe : une nouveauté pour quantifier l'érythropoïèse

in Médecine et Hygiène (1991), 49

Les échanges de fer entre les tissus se font par l'intermédiaire de la transferrine plasmatique qui donne son fer aux cellules grâce à son interaction avec un récepteur mambranaire spécifique. Une forme ... [more ▼]

Les échanges de fer entre les tissus se font par l'intermédiaire de la transferrine plasmatique qui donne son fer aux cellules grâce à son interaction avec un récepteur mambranaire spécifique. Une forme soluble du récepteur de la transferrine a été mise en évidence dans le sang. Son dosage par méthode ELISA représente une excellente mesure quantitative de l'érythropoïèse qui devrait remplacer les méthodes anciennes moins fiables (réticulocytes) et plus complexes (tests au fer marqué). [less ▲]

Red blood cell ionic concentration and platelet cytosolic calcium and pH in essential hypertension and chronic failure

in Acta Clinica Belgica (1991), 46(4), 259

Bibliography

in Maes-Jelinek, Hena (Ed.) Wilson Harris: The Uncompromising Imagination (1991)

Spatially continuous processing within a raster based GIS : some examples of geographical models

in Bulletin de la Société belge de Géographie - SOBEG (1991), 2

La représentation d'un territoire en mode raster introduit une discrétisation qui peut être considérée, en première approximation, comme le résultat d'un échantillonnage à deux dimensions de cette surface ... [more ▼]

La représentation d'un territoire en mode raster introduit une discrétisation qui peut être considérée, en première approximation, comme le résultat d'un échantillonnage à deux dimensions de cette surface. Sous cette forme, un attribut spatialement continu constitue une couche de données directement accessible aux systèmes d'information géographique (S.I.G.) hybrides (raster/vecteur). Les avantages de cette représentation sont déjà exploités pour visualiser et traiter des phénomènes physiques surfaciques, tels que les modèles numériques de terrain. Une procédure identique peut être appliquée aux surfaces théoriques issues de l'application de modèles géographiques. En outre, les propriétés du mode raster sont susceptibles d'offrir des solutions graphiques soit plus simples, soit en l'absence de solutions analytiques. Cet article illustre ces avantages sur quelques modèles bien connus de l'analyse spatiale. [less ▲]

Les parcs d'activités économiques en Province de Liège : un premier bilan

in Merenne-Schoumaker, Bernadette (Ed.) Les parcs d'activités économiques de la Province de Liège : Bilan et perspectives (1991)

Review of 30 years of planning and management of business parks in the province of Liege

Three-dimensional electron microscopy of ribosomal chromatin in two higher plants: a cytochemical, immunocytochemical, and in situ hybridization approach.

in Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society (1991), 39(11), 1495-506

We report the 3-D arrangement of DNA within the nucleolar subcomponents from two evolutionary distant higher plants, Zea mays and Sinapis alba. These species are particularly convenient to study the ... [more ▼]

We report the 3-D arrangement of DNA within the nucleolar subcomponents from two evolutionary distant higher plants, Zea mays and Sinapis alba. These species are particularly convenient to study the spatial organization of plant intranucleolar DNA, since their nucleoli have been previously reconstructed in 3-D from serial ultra-thin sections. We used the osmium ammine-B complex (a specific DNA stain) on thick sections of Lowicryl-embedded root fragments. Immunocytochemical techniques using anti-DNA antibodies and rDNA/rDNA in situ hybridization were also applied on ultra-thin sections. We showed on tilted images that the OA-B stains DNA throughout the whole thickness of the section. In addition, very low quantities of cytoplasmic DNA were stained by this complex, which is now the best DNA stain used in electron microscopy. Within the nucleoli the DNA was localized in the fibrillar centers, where large clumps of dense chromatin were also visible. In the two plant species intranucleolar chromatin forms a complex network with strands partially linked to chromosomal nucleolar-organizing regions identified by in situ hybridization. This study describes for the first time the spatial arrangement of the intranucleolar chromatin in nucleoli of higher plants using high-resolution techniques. [less ▲]

Effects of exposure to cadmium on calcium metabolism : a population study

in British Journal of Industrial Medicine (1991), 48

The objective was to investigate the hypothesis that environmental exposure to cadmium may affect calcium metabolism in the population at large. The 1987 participants (965 men and 1022 women), from 20 to ... [more ▼]

The objective was to investigate the hypothesis that environmental exposure to cadmium may affect calcium metabolism in the population at large. The 1987 participants (965 men and 1022 women), from 20 to 80 years old, constituted a random sample of the population of four Belgian districts. The urinary excretion of cadmium, a mesure of lifetime exposure, averaged 9.3 nmo/24h in men (range 0.4-324 nmol/24h) and 7.1 nmol/24h (range 0.1-71 nmol/24h) in women. Serum alkaline phosphatase activity and the urinary excretion of calcium correlated significantly and positively with urinary cadmium excretion in both men and women, and serum total calcium concentration negatively with urinary cadmium excretion in men only. The regression coefficients obtained after adjustment for significant covariates indicated that when urinary cadmium excretion increased twofold, serum alkaline phosphatase activity and urinary calcim excretion rose by 3-4% and 0.25 mmol/24h respectively, whereas in men serum total calcium concentration fell by 6 µmol/l. After adjustment for significant covariates the relation between serum total calcium concentration and urinary cadmium excretion was not significant in women. The findings suggest that even at environmental exposure levels calcium metabolism is gadually affected, as cadmium accumulates in the body. The morbidity associated with this phenomenon in industrialised countries remains presently unknown and requires further investigation. [less ▲]

Predictive value and rate of change of blood pressure throughout adolescence : a Belgian prospective study.

in Acta Clinica Belgica (1991), 4