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See detailLe cas clinique du mois. Le Twiddler's syndrome.
SakalihasanN, Natzi ULg; Radermacher, V.; Chevolet, C. et al

in Revue Médicale de Liège (2005), 60(7-8), 647-8

The Twiddler's syndrome is characterized by the migration of pacemaker's leads due to rotation of the pulse generator. In our case, ventricular leads coiled in the upper side of the right atrium with ... [more ▼]

The Twiddler's syndrome is characterized by the migration of pacemaker's leads due to rotation of the pulse generator. In our case, ventricular leads coiled in the upper side of the right atrium with stimulation of pectoralis major muscle during left decubitus lateralis position. [less ▲]

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See detail5-Hydroxytryptamine 1A receptors, major depression, and suicidal behavior.
Pitchot, William ULg; Hansenne, Michel ULg; Pinto, Emmanuel ULg et al

in Biological Psychiatry (2005), 58(11), 854-8

BACKGROUND: Several lines of evidence suggest a clear relationship between serotonin (5-hydroxytryptamine, 5-HT) hypoactivity and suicidal behavior across several psychiatric diagnoses. Few data are ... [more ▼]

BACKGROUND: Several lines of evidence suggest a clear relationship between serotonin (5-hydroxytryptamine, 5-HT) hypoactivity and suicidal behavior across several psychiatric diagnoses. Few data are available, however, regarding the possible specific role of 5-HT1A receptors in the biology of suicidality. Therefore, the aim of our study was to use a neuroendocrine strategy to test the hypothesis of a role for 5-HT1A receptors in the biology of suicidal behavior. METHODS: Hormonal (adrenocorticotropic hormone [ACTH], cortisol, prolactin [PRL]) and temperature responses after administration of flesinoxan, a highly potent and selective 5-HT1A receptor full agonist, were assessed in 40 inpatients with major depression, divided into two subgroups (20 suicide attempters and 20 nonattempters), compared with 20 normal control subjects matched for gender and age. RESULTS: Compared with nonattempters, suicide attempters exhibited significantly lower PRL (p = .01), cortisol (p = .014), and temperature (p = .0002) responses. Prolactin (p = .007), cortisol (p = .04), and temperature (p = .00003) responses were also decreased in suicide attempters compared with normal control subjects. In contrast, we did not observe any significant differences in hormonal or temperature responses to flesinoxan between depressed patients without a history of suicide attempt and normal control subjects. CONCLUSIONS: The present study tends to confirm the role of 5-HT and more specifically 5-HT1A receptors in the biology of suicidal behavior in major depression. [less ▲]

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See detailApplication of a data minig based technique for the evaluation of transmission expansion plans
Druet, Christophe; Vassena, Stefano; Rousseaux, Patricia ULg et al

in Proceedings of the 15th Power System Computation Conference (PSCC) (2005)

This paper describes a methodology for the study of long-term network planning under uncertainties. In this approach the major external uncertainties during the planning horizon are modelled as macro ... [more ▼]

This paper describes a methodology for the study of long-term network planning under uncertainties. In this approach the major external uncertainties during the planning horizon are modelled as macro-scenarios at different future time instants. The random nature of actual operating conditions is taken into account by using a probabilistic model of micro-scenarios based on past statistics. MonteCarlo simulations are used to generate and simulate a specified number of scenarios. Data mining techniques are then applied to the simulations results collected in a database, so as to extract information and to rank scenarios and network reinforcements according to different performance criteria. The paper describes the application of this approach on a real transmission planning problem faced by the Belgian transmission system operator. [less ▲]

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See detailUne explication théorique à l’existence des coopératives agréées et des sociétés à finalité sociale en Belgique
Mertens de Wilmars, Sybille ULg

in Non Marchand : Management, Droit et Finance (2005), (16), 13-27

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See detailHéliodermie, héliophiles et héliophobes.
Quatresooz, Pascale ULg; Uhoda, I.; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2005), 60 Suppl 1

The cumulative effect of lifelong sun exposures induces skin alterations which are coined helioderma. The manifestations of helioderma vary according to the body site. This is particularly the case for ... [more ▼]

The cumulative effect of lifelong sun exposures induces skin alterations which are coined helioderma. The manifestations of helioderma vary according to the body site. This is particularly the case for the prominent differences in the expression of solar elastosis. This condition is commonly more severe on the face and nape of the neck than on the forearms and back of the hands. The age, phototype and behaviour regarding sun exposure are cofactors responsible for the severity of solar elastosis. [less ▲]

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See detailFatal herpes simplex virus infection in Darier disease under corticotherapy.
Nikkels, Arjen ULg; Beauthier, F.; Quatresooz, Pascale ULg et al

in European Journal of Dermatology (2005), 15(4), 293-7

A 67-year-old man is presented with longstanding and severe Darier disease treated by topical antiseptics and potent corticosteroids, in combination with oral glucocorticoids and etretinate. After cardiac ... [more ▼]

A 67-year-old man is presented with longstanding and severe Darier disease treated by topical antiseptics and potent corticosteroids, in combination with oral glucocorticoids and etretinate. After cardiac bypass surgery in 1997, the patient experienced herpes simplex virus (HSV type-1) infection of the skin that was treated by intravenous aciclovir. In 2003, he presented a widespread atypical exacerbation of his Darier disease, involving the face, trunk, buttocks, intertriginous areas and arms. Initial clinical signs and bacteriological findings suggested a bacterial involvement by multiresistant Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Proteus mirabilis. Despite antibiotherapy, the clinical presentation progressively worsened. A skin biopsy was performed and immunohistochemical examination identified a type-2 HSV infection. Although intravenous aciclovir was administered, the widespread cutaneous HSV infection was followed by systemic dissemination. A severe acute respiratory distress syndrome (ARDS) developed, leading to a fatal issue. At autopsy, a severe interstitial type-2 HSV pneumonitis with extensive necrotic areas was found, in association with gastro-intestinal involvement. This case represents, to the best of our knowledge, the first case of Darier disease presenting a fatal type-2 HSV infection. It underlines the importance of rapidly recognizing HSV infection in Darier disease and stresses the risk of lethal outcome. The different risk factors for HSV infection in this patient are reviewed. [less ▲]

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See detailResistance of collagenase-2 (MMP-8) deficient mice to TNF-induced lethal hepatitis
Van Lint, Ph; Wielockx, B.; Puimege, L. et al

in Journal of Immunology (2005), 175(11), 7642-9

Acute fulminant liver failure is a serious worldwide health problem. Despite maximal supportive intensive care treatment, the disease offers a poor prognosis, with mortality rates of >80%. We have ... [more ▼]

Acute fulminant liver failure is a serious worldwide health problem. Despite maximal supportive intensive care treatment, the disease offers a poor prognosis, with mortality rates of >80%. We have previously shown that a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) confers complete protection in a mouse model of TNF-induced lethal hepatitis, thereby suggesting the possibility of protecting cancer patients against the deleterious side effects of TNF therapy. In our search for the individual matrix metalloproteinases involved, we found that the recently generated MMP-8-deficient mice are significantly protected against TNF-induced acute hepatitis. In contrast to their wild-type counterparts, MMP-8-null mice display very little hepatocyte necrosis and apoptosis, resulting in a much better survival outcome. We found that these animals clearly display impaired leukocyte influx into the liver and no release of the neutrophil-specific, LPS-induced CXC chemokine. Our findings provide evidence that MMP-8 plays an essential role in acute liver failure and might be a promising new target for the treatment for this illness. [less ▲]

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See detailMimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype.
Swinnen, J. V.; Beckers, A.; Brusselmans, K. et al

in Cancer Research (2005), 65(6), 2441-8

Aggressive cancer cells typically show a high rate of energy-consuming anabolic processes driving the synthesis of lipids, proteins, and DNA. Here, we took advantage of the ability of the cell-permeable ... [more ▼]

Aggressive cancer cells typically show a high rate of energy-consuming anabolic processes driving the synthesis of lipids, proteins, and DNA. Here, we took advantage of the ability of the cell-permeable nucleoside 5-aminoimidazole-4-carboxamide (AICA) riboside to increase the intracellular levels of AICA ribotide, an AMP analogue, mimicking a low energy status of the cell. Treatment of cancer cells with AICA riboside impeded lipogenesis, decreased protein translation, and blocked DNA synthesis. Cells treated with AICA riboside stopped proliferating and lost their invasive properties and their ability to form colonies. When administered in vivo, AICA riboside attenuated the growth of MDA-MB-231 tumors in nude mice. These findings point toward a central tie between energy, anabolism, and cancer and suggest that the cellular energy sensing machinery in cancer cells is an exploitable target for cancer prevention and/or therapy. [less ▲]

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See detailComment je traite.... Un carcinome basocellulaire par l'imiquimod topique (Aldara).
Pierard-Franchimont, Claudine ULg; Nikkels, Arjen ULg; Paquet, Philippe ULg et al

in Revue Médicale de Liège (2005), 60(4), 207-209

Basal cell carcinoma is the most frequent cancer in humans. Several clinical types are distinguished. They are bound to distinct evolutive prognosis. The surgical excision is the treatment of choice which ... [more ▼]

Basal cell carcinoma is the most frequent cancer in humans. Several clinical types are distinguished. They are bound to distinct evolutive prognosis. The surgical excision is the treatment of choice which is rarely followed by recurrence. However, when the lesion is superficial and non aggressive and when the body site is adequate, topical applications of imiquimod can provoke the neoplastic regression. This type of immunotherapy brings 70 to 90% complete remission. A medical follow-up of the treated site is mandatory for a couple of years. [less ▲]

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See detailComment je traite ... un lentigo malin par l'imiquimod topique (Aldara).
Bourguignon, Raphaël; Paquet, Philippe ULg; Quatresooz, Pascale ULg et al

in Revue Médicale de Liège (2005), 60(9), 691-4

Lentigo maligna is a special form of in situ cutaneous melanoma that develops on the face of sun worshipers. The topic immunostimulator imiquimod can destroy the neoplasm before it expresses its invasive ... [more ▼]

Lentigo maligna is a special form of in situ cutaneous melanoma that develops on the face of sun worshipers. The topic immunostimulator imiquimod can destroy the neoplasm before it expresses its invasive potential. A strict clinical follow-up of the treated zone must be observed at least 5 years to detect any early sign of recurrence. [less ▲]

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See detailStigmates cutanés du diabète.
Flagothier, Caroline ULg; Quatresooz, Pascale ULg; Bourguignon, Raphaël et al

in Revue Médicale de Liège (2005), 60(5-6), 553-9

A number of relationships exist between diabetes mellitus and a series of cuteanous disorders. Skin lesions may reveal diabetes in a more or less specific way. They may also represent complications ... [more ▼]

A number of relationships exist between diabetes mellitus and a series of cuteanous disorders. Skin lesions may reveal diabetes in a more or less specific way. They may also represent complications supervening in an already treated diabetic patient. Some of these dermatoses (acanthosis nigricans, purpuric and pigmented capillaritis) are markers of macrovascular complications. The same disorders and some others (xerosis, Dupuytren's disease) are more frequently associated with microangiopathy in Type II diabetes. Other skin diseases (alopecia areata, vitiligo) are markers of auto-immunity in Type I diabetes. [less ▲]

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See detailPhotobiologie cellulaire.
Quatresooz, Pascale ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2005), 60 Suppl 1

The various cell lines of the epidermis and dermis can be activated or conversely altered by actinic irradiations. Keratinocytes, melanocytes, Langerhans cells and connective tissue cells are the main ... [more ▼]

The various cell lines of the epidermis and dermis can be activated or conversely altered by actinic irradiations. Keratinocytes, melanocytes, Langerhans cells and connective tissue cells are the main targets. [less ▲]

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See detailLes compétences et les familles de situations. Etude exploratoire de la complexité d’un jugement.
Chenu, Florent ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2005), 21-22

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See detailDecrease of serum concentrations of dioxins and PCBs in Belgium between 2000 and 2003
Fierens, Sébastien; Heilier, Jean-François; Eppe, Gauthier ULg et al

in Organohalogen Compounds (2005), 67

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See detailLa maîtrise des outils et des concepts transversaux aux logiciels informatiques. Une histoire d’expertise ?
Chenu, Florent ULg; Mélotte, Christine

in Cahiers des Sciences de l'Education (Les) (2005), 23-24

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See detailRestoration of Posidonia oceanica meadows : means and limitations.
Gobert, Sylvie ULg; Lepoint, Gilles ULg; Bouquegneau, Jean-Marie ULg et al

in Proceedings of the seventh international conference on the Mediterranean coastal environment. Medcoast 05 (2005)

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See detailComment j'explore....une pathologie d'aspect microscopique cutané apparemment sain.
Quatresooz, Pascale ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2005), 60(2), 117-20

Some dermatologic disorders named "Invisible dermatoses" are defined by obvious clinical signs while histologic alterations remain discrete. This situation may lead to clinico-pathological discrepancies ... [more ▼]

Some dermatologic disorders named "Invisible dermatoses" are defined by obvious clinical signs while histologic alterations remain discrete. This situation may lead to clinico-pathological discrepancies impeding the establishment of a diagnosis. In other cases, the skin looks clinically normal but the histological examination allows to disclose some systemic diseases. Systematic analysis of the skin biopsy complemented by histochemical and immunohistochemical techniques may help reach the diagnosis. [less ▲]

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