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See detailMédecins et vétérinaires célestes d’Ardenne
Donneau, Olivier ULg

in Guérisseurs d’hier et d’aujourd’hui (2003)

Short history of the evolution of the cults devoted to the healing saints in the Ardenne (Belgium).

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See detailLes guérisseurs dans les provinces belges de Liège et de Luxembourg : quelques données chiffrées
Donneau, Olivier ULg

in Guérisseurs d’hier et d’aujourd’hui (2003)

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See detailEffect of nutrient enrichments on the bacterial assemblage of Antarctic soils contaminated by diesel or crude oil
Delille, Daniel; Pelletier, Emilien; Delille, Bruno ULg et al

in Polar Record (2003), 39(4), 309-318

There is an urgent need to develop new technologies to address the problem of soil remediation in high-latitude regions. A field study was initiated in January 1997 in two contaminated soils in Terre ... [more ▼]

There is an urgent need to develop new technologies to address the problem of soil remediation in high-latitude regions. A field study was initiated in January 1997 in two contaminated soils in Terre Adélie (Antarctica) with the objective of determining the long-term effectiveness of two bioremediation agents on total and hydrocarbon-degrading microbial assemblages under severe Antarctic conditions. This study was conducted in two steps, from January to July 1997 and from February to November 1999 in the Géologie Archipelago (Terre Adélie, 66°40′S, 140°01′E). Changes in bacterial communities were monitored in situ after crude oil or diesel addition in a series of 600 cm2 soil sectors (20×30 cm). Four contaminated sectors were used for each experiment: diesel oil (10 ml), diesel oil (10 ml) + fertilizer (1 ml), Arabian light crude oil (10 ml), and crude oil (10 ml) + fertilizer (1 ml). Two different bioremediation agents were used: a slow release fertilizer Inipol EAP-22 (Elf Atochem) in 1997 and a fish compost in 1999. Plots were sampled on a regular basis during a three-year period. All samples were analysed for total, saprophytic psychrophilic, and hydrocarbon-utilising bacteria. A one order of magnitude increase of saprophytic and hydrocarbon-utilising micro-organisms occurred during the first month of the experiment in most of the contaminated enclosures, but no clear differences appeared between fertilized and unfertilized plots. Diesel-oil contamination induced a significant increase of all bacterial parameters in all contaminated soils. Crude-oil contamination had no clear effects on microbial assemblages. It was clear that the microbial response could be rapid and efficient in spite of the severe weather conditions. However, microbial growth was not clearly improved in the presence of bioremediation agents. [less ▲]

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See detailApproximation algorithms for the design of SDH/SONET networks
Brauner, Nadia; Crama, Yves ULg; Finke, Gerd et al

in RAIRO : Operations Research = Recherche Opérationnelle (2003), 37(4, OCT-DEC), 235-247

In this paper, a graph partitioning problem that arises in the design of SONET/SDH networks is defined and formalized. Approximation algorithms with performance guarantees are presented. To solve this ... [more ▼]

In this paper, a graph partitioning problem that arises in the design of SONET/SDH networks is defined and formalized. Approximation algorithms with performance guarantees are presented. To solve this problem efficiently in practice, fast greedy algorithms and a tabu-search method are proposed and analyzed by means of an experimental study. [less ▲]

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See detailMetabolising risk: food scares and the un/re-making of Belgian beef
Stassart, Pierre M ULg; Whatmore, Sarah J.

in Environment & Planning A (2003), 35

In this paper we explore the event of foodscares as an example of what Callon calls 'hot situations', in which the landscape of competing knowledge claims is at its most molten, and alternative production ... [more ▼]

In this paper we explore the event of foodscares as an example of what Callon calls 'hot situations', in which the landscape of competing knowledge claims is at its most molten, and alternative production and consumption practices galvanise new modes of sense-making against the market and state-sanctioned rationalities of industrialisation. Through a case study of the Belgian cooperative Coprosain and its meat products, we examine the 'stuff' of food as a ready messenger of connectedness and affectivity in which 'risk' is transacted as a property both of the growing distance between the spaces of production and consumption and of the enduring metabolic intimacies between human and nonhuman bodies. [less ▲]

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See detailStochastic modelling of the hydrogeological environment in low permeability sediment
Huysmans, Marijke; Berckmans, Arne; Feyen, Luc et al

in Proceedings of IAMG 2003 (2003)

In Belgium, the Boom Clay is being considered as a potential host formation for the disposal of nuclear waste. Part of the safety assessment and feasibility studies of a potential nuclear waste disposal ... [more ▼]

In Belgium, the Boom Clay is being considered as a potential host formation for the disposal of nuclear waste. Part of the safety assessment and feasibility studies of a potential nuclear waste disposal consists of hydrogeological modeling. In order to model the groundwater flow and possible radionuclide transport in the clay, the spatial distribution of the hydraulic conductivity of the clay has to be assessed. In this study, geostatistical methods are used to characterize the hydraulic conductivity field. More specific, direct sequential simulation of the hydraulic conductivity is carried out, using measurements of hydraulic conductivity and 4 types of soft data or secondary variables: resistivity logs, gamma ray logs, grain size measurements and descriptions of the lithology. The primary and secondary information is analyzed with geostatistical tools and combined to generate 100 fields of the hydraulic conductivity of the Boom Clay. Next, each field is input to a groundwater flow model to predict the advective travel time of constituents released from the disposed waste in the Boom Clay to the aquifers surrounding the Boom Clay. Statistical analysis of the ensemble of model predictions results in a predictive distribution for the advective travel time. This distribution reflects the uncertainty of the advective travel time that results from the uncertainty of the spatial distribution of the hydraulic conductivity of the Boom Clay [less ▲]

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See detailComplex Hydrogeological Study of the Alluvial Transboundary Aquifer of Szamos/Somes (Romania-Hungary)
Lenart, Laszlo; Madarasz, Tamas; Miko, Lajos et al

in Water resources management in the 21th century. Subtheme 4, Relevance and sustainability of the intensive groundwater developments (2003)

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See detailThermometer ions for matrix-enhanced laser desorption/ionization internal energy calibration
Greisch, Jean-François ULg; Gabelica, Valérie ULg; Remacle, Françoise ULg et al

in Rapid Communications in Mass Spectrometry : RCM (2003), 17(16), 1847-1854

This work describes a method to use relative fragmentation yields to characterize the internal energy distribution of ions produced by matrix-enhanced laser desorption/ionization mass spectrometry (MELDI ... [more ▼]

This work describes a method to use relative fragmentation yields to characterize the internal energy distribution of ions produced by matrix-enhanced laser desorption/ionization mass spectrometry (MELDI-MS, see: Wright LG, Cooks RG, Wood KL. Biomed. Mass Spectrom. 1985; 12:153162). Assuming that the fragmentation proceeds statistically and that the collisions in the source lead to a Boltzmann-like distribution of the internal energy, a characteristic parameter, the effective temperature, is introduced to describe the internal energy distribution of the ions observed. The hypotheses, advantages and drawbacks of the implementation of the method that uses substituted benzylpyridinium salts as thermometer ions are discussed. Use is made of two matrices that produce no matrix cations in MELDI and are suitable for small cationic salts. The actual value of this effective temperature significantly depends on an accurate determination of the threshold dissociation energies and on the time spent in the source, in addition to the statistical hypothesis itself. The method could be applied to normalize spectra in order to compare results issued from different instruments. [less ▲]

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See detailUpdating the Jungfraujoch FTIR databases : current status
Duchatelet, Pierre ULg; Mahieu, Emmanuel ULg; Zander, Rodolphe ULg et al

(2003)

Since the middle of the 20th century, the University of Liège has been active at the International Scientific Station of the Jungfraujoch (ISSJ) in the Swiss Alps (46.5°N, 8.0°E, 3580m asl) to study the ... [more ▼]

Since the middle of the 20th century, the University of Liège has been active at the International Scientific Station of the Jungfraujoch (ISSJ) in the Swiss Alps (46.5°N, 8.0°E, 3580m asl) to study the chemical composition of both the solar photosphere and the Earth’s atmosphere. Since 1989, the ISSJ is an accepted site of the northern midlattitude primary Alpine station of the NDSC (Network for the Detection of Stratospheric Change). This acceptance resulted from earlier monitoring activities by Ulg of a large number of atmospheric constituents. Within the NDSC frame, a special attention and many efforts have been devoted to the monitoring of the most important atmospheric constituents involved both in the erosion of stratospheric ozone and in the greenhouse capacity of the troposphere, after it became clear that human activities have a direct impact on these two processes. Using two high resolution Fourier transform infrared (FTIR) spectrometers, over 25000 wide-band solar spectra encompassing nearly 1700 days since the mid 1980s have been recorded and analyzed to study, quasi simultaneously and repeatedly, local, seasonal and secular variations of some 20 gaseous telluric species. So far, most results have been reported, demonstrating the power of infrared spectrometric solar observations to characterize the chemical composition of the atmosphere. These datas, archived in terms of total vertical column abundances (e.g., at the NDSC-Data Host Facility; http://www.ndsc.ws), are expressed in number molecules per cm2 above the site using best-know input parameters (i.e. spectroscopic-, instrumental-, environmental-) in the retrieval procedure. Meanwhile, more sophisticated algorithms, based on the “Rodgers” optimal estimation method, have been developed, allowing to derive partial tropospheric- and stratospheric columns for various species, including HCl, ClONO2, O3, HF, CO, N2O, CH4, HCN, OCS. This contribution reports related results for HCl and ClONO2. [less ▲]

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See detailLow T-cell chimerism is not followed by graft rejection after nonmyeloablative stem cell transplantation (NMSCT) with CD34-selected PBSC.
Baron, Frédéric ULg; Baudoux, Etienne ULg; Frere, Pascale ULg et al

in Bone Marrow Transplantation (2003), 32(8), 829-34

We investigate the feasibility of CD34-selected peripheral blood stem cell (PBSC) transplantation followed by pre-emptive CD8-depleted donor lymphocyte infusions (DLI) after a minimal conditioning regimen ... [more ▼]

We investigate the feasibility of CD34-selected peripheral blood stem cell (PBSC) transplantation followed by pre-emptive CD8-depleted donor lymphocyte infusions (DLI) after a minimal conditioning regimen. Six patients with advanced hematological malignancies ineligible for a conventional myeloablative transplant (n=5) or metastatic renal cell carcinoma (n=1), and with an HLA-identical (n=4) or alternative (n=2) donor were included. The nonmyeloablative conditioning regimen consisted in 2 Gy TBI alone (n=4), 2 Gy TBI and fludarabine (RCC patient, n=1) or cyclophosphamide and fludarabine (patient who had previously received 12 Gy TBI, n=1). Post transplant immunosuppression was carried out with cyclosporin (CyA) and mycophenolate mofetil (MMF). Initial engraftment was achieved in all patients. One out of six patients (17%) experienced grade > or =2 acute GVHD only after abrupt cyclosporin discontinuation and alpha interferon therapy for life-threatening tumor progression. T-cell chimerism was 23% (19-30) on day 28, 32% (10-35) on day 100, 78% (49-95) on day 180 and 99.5% (99-100) on day 365. Three out of four patients who had measurable disease before the transplant experienced a complete response. We conclude that CD34-selected NMSCT followed by CD8-depleted DLI is feasible and preserves engraftment and apparently also the graft-versus-leukemia (GVL) effect. Further studies are needed to confirm this encouraging preliminary report. [less ▲]

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See detailTransmission of chronic myeloid leukemia through peripheral-blood stem-cell transplantation.
Baron, Frédéric ULg; Dresse, Marie-Françoise; Beguin, Yves ULg

in New England Journal of Medicine [=NEJM] (2003), 349(9), 913-4

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See detailRecombinant human erythropoietin therapy is very effective after an autologous peripheral blood stem cell transplant when started soon after engraftment.
Baron, Frédéric ULg; Frere, Pascale ULg; Fillet, Georges ULg et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (2003), 9(15), 5566-72

PURPOSE: Previous trials of recombinant human erythropoietin (rHuEpo) therapy after autologous hematopoietic stem cell transplantation have administered very high doses of i.v. rHuEpo starting on day 1 ... [more ▼]

PURPOSE: Previous trials of recombinant human erythropoietin (rHuEpo) therapy after autologous hematopoietic stem cell transplantation have administered very high doses of i.v. rHuEpo starting on day 1 and continuing for 1-2 months until erythroid engraftment and have shown no benefit of rHuEpo therapy. We sought to establish a more effective use of rHuEpo in this setting. EXPERIMENTAL DESIGN: In this report, we show in a first cohort of 45 lymphoma or myeloma patients undergoing peripheral blood stem cell transplant (control group) that endogenous erythropoietin levels are high for the degree of anemia during the first 3 weeks after transplant but become adequate or slightly decreased thereafter. We thus enrolled 41 consecutive similar patients in a trial of rHuEpo therapy at a dose of 500 units/kg/week started on day 30 after the transplant. RESULTS: The 12-week probability of achieving hemoglobin (Hb) levels of 13 g/dl was 87% in rHuEpo-treated patients versus 14% in controls (P = 0.0001). Mean Hb levels were significantly higher in the rHuEpo group than in the control group from day 42 through day 150 after transplant (Ps of <0.05 to <0.001). Two of 41 patients in the rHuEpo group versus 12 of 45 patients in the control group had Hb levels of <9 g/dl between day 42 and day 100 after the transplant (P = 0.0078). CONCLUSIONS: Anemia after autologous peripheral blood stem cell transplant is exquisitely sensitive to rHuEpo when therapy is started soon after engraftment. This is the first convincing report showing that rHuEpo is effective in this setting. Our data set the stage for a more rational use of rHuEpo after autologous hematopoietic stem cell transplantation and should renew interest in erythropoietin therapy in this setting. Prospective, randomized trials should investigate the impact of rHuEpo therapy on transfusion requirements and quality of life. [less ▲]

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See detailLong-term disease-free survival in patients with angioimmunoblastic T-cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation.
Schetelig, Johannes; Fetscher, Sebastian; Reichle, Albrecht et al

in Haematologica (2003), 88(11), 1272-8

BACKGROUND AND OBJECTIVES: Patients with angioimmunoblastic T-cell lymphoma (AIL) have a poor prognosis with conventional treatment. DESIGN AND METHODS: We initiated an EBMT-based survey studying the ... [more ▼]

BACKGROUND AND OBJECTIVES: Patients with angioimmunoblastic T-cell lymphoma (AIL) have a poor prognosis with conventional treatment. DESIGN AND METHODS: We initiated an EBMT-based survey studying the impact of high-dose chemotherapy (HDCT) and autologous hematopoietic stem cell transplantation in patients with AIL. Data on 29 patients, who were transplanted between 1992 and 1998 in 16 transplant centers, were collected on standardized documentation forms. RESULTS: The median age at transplantation was 53 years. HDCT was given as part of 1st-line therapy (N=14; 48%) or 2nd/3rd-line therapy (N=15; 52%). Regimens for the mobilization of peripheral blood stem cells (PBSC) included VIPE (N=7; 26%), DexaBEAM (N=6; 22%), CHOP-like regimens (N=6; 22%), other regimens (N=5; 19%) or alternatively growth factor alone (N=3; 11%). The median yield of PBSC was 3.8x106 CD34+cells/kg. Two patients received autologous bone marrow. The HDCT consisted of BEAM-type regimens in 16 patients, ICE-type regimens in 7, and other regimens in 6 patients. There was one treatment-related death. The rate of complete remissions increased from 45% before HDCT to 76% after HDCT. As of January 2003, after a median observation time of living patients of 5 years (range 2.5 to 10 years), 14 patients have died (13 from progressive disease), and 15 patients are alive. The probability of 5-year overall and event-free survival was 44% (95% CI, 22% to 66%) and 37% (95% CI, 17% to 57%), respectively. Long-term disease-free survival was observed in patients transplanted during 1st-line treatment as well as in the context of 2nd/3rd-line therapy. INTERPRETATION AND CONCLUSIONS: There is evidence that AIL is susceptible to high-dose chemotherapy. HDCT and autologous stem cell transplantation should be considered in selected patients with AIL. [less ▲]

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See detailComment je traite ... la leucemie myeloide chronique (LMC).
Hafraoui, Kaoutar ULg; Humblet-Baron, Stéphanie ULg; Baron, Frédéric ULg et al

in Revue Médicale de Liège (2003), 58(1), 7-12

This review article describes the identification of the tyrosine kinase BCR/ABL as the hallmark of chronic myeloid leukemias (CML) as well as the development of a specific inhibitor of this tyrosine ... [more ▼]

This review article describes the identification of the tyrosine kinase BCR/ABL as the hallmark of chronic myeloid leukemias (CML) as well as the development of a specific inhibitor of this tyrosine kinase, the STI571 (Glivec, imatinib mesylate). The authors discuss the results of a phase I and three phase II trials reporting the efficacy of STI571 as treatment for CML patients and propose two simplified algorithms that may help to guide decision-making for the individual patient. [less ▲]

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See detailSoluble transferrin receptor for the evaluation of erythropoiesis and iron status.
Beguin, Yves ULg

in Clinica Chimica Acta (2003), 329(1-2), 9-22

Iron transport in the plasma is carried out by transferrin, which donates iron to cells through its interaction with a specific membrane receptor, the transferrin receptor (TfR). A soluble form of the TfR ... [more ▼]

Iron transport in the plasma is carried out by transferrin, which donates iron to cells through its interaction with a specific membrane receptor, the transferrin receptor (TfR). A soluble form of the TfR (sTfR) has been identified in animal and human serum. Soluble TfR is a truncated monomer of tissue receptor, lacking its first 100 amino acids, which circulates in the form of a complex of transferrin and its receptor. The erythroblasts rather than reticulocytes are the main source of serum sTfR. Serum sTfR levels average 5.0+/-1.0 mg/l in normal subjects but the various commercial assays give disparate values because of the lack of an international standard. The most important determinant of sTfR levels appears to be marrow erythropoietic activity which can cause variations up to 8 times below and up to 20 times above average normal values. Soluble TfR levels are decreased in situations characterized by diminished erythropoietic activity, and are increased when erythropoiesis is stimulated by hemolysis or ineffective erythropoiesis. Measurements of sTfR are very helpful to investigate the pathophysiology of anemia, quantitatively evaluating the absolute rate of erythropoiesis and the adequacy of marrow proliferative capacity for any given degree of anemia, and to monitor the erythropoietic response to various forms of therapy, in particular allowing to predict response early when changes in hemoglobin are not yet apparent. Iron status also influences sTfR levels, which are considerably elevated in iron deficiency anemia but remain normal in the anemia of inflammation, and thus may be of considerable help in the differential diagnosis of microcytic anemia. This is particularly useful to identify concomitant iron deficiency in a patient with inflammation because ferritin values are then generally normal. Elevated sTfR levels are also the characteristic feature of functional iron deficiency, a situation defined by tissue iron deficiency despite adequate iron stores. The sTfR/ferritin ratio can thus describe iron availability over a wide range of iron stores. With the exception of chronic lymphocytic leukemia (CLL) and high-grade non-Hodgkin's lymphoma and possibly hepatocellular carcinoma, sTfR levels are not increased in patients with malignancies. We conclude that soluble TfR represents a valuable quantitative assay of marrow erythropoietic activity as well as a marker of tissue iron deficiency. [less ▲]

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See detailCell cycle duration at the time of maternal zygotic transition for in vitro produced bovine embryos: effect of oxygen tension and transcription inhibition.
Lequarré, Anne-Sophie ULg; Marchandise, J.; Massip, A. et al

in Biology of Reproduction (2003), 69(5), 1707-13

Early embryonic cleavages are mostly regulated by maternal components then control of development progressively depends on newly synthesized zygotic products. The timing of the first cleavages is a way to ... [more ▼]

Early embryonic cleavages are mostly regulated by maternal components then control of development progressively depends on newly synthesized zygotic products. The timing of the first cleavages is a way to assess embryo quality. The goal of this study was to evaluate the duration of the fourth cell cycle, at the time of maternal-to-zygotic transition (MZT) in in vitro-produced bovine embryos by means of cinematographic analysis. We found that 75% of the embryos displayed a long fourth cycle (43.5 +/- 5.4 h) whereas the remaining embryos had a very short fourth cell cycle (8.9 +/- 2.9 h). Both groups did not differ in cleavage rhythm up to the eight-cell stage and timing of cavitation and blastocyst expansion was identical. However, embryos with a short fourth cell cycle had a better blastocyst rate than embryos with a long cycle (59% versus 38%, P < 0.01). Total cell number, inner cell mass (ICM):total cell ratio, and hatching rate were identical for blastocysts produced from embryos with either a long or a short fourth cell cycle. In a second experiment, we showed that increasing the oxygen tension, from 5% to 20%, decreased the percentage of embryos with a short fourth cell cycle, from 25% to 11% (P < 0.01), indicating that suboptimal culture conditions can influence the length of this cycle. Finally, we investigated whether fourth cell cycle duration could be influenced by transcription inhibition. With alpha-amanitin added at 18 h postinsemination (HPI), cleavage was reduced (66% versus 79%) and, at 70 HPI, the 9- to 16-cell rate increased (50% versus 25%) concomitantly with a 5- to 8-cell rate decrease (16% versus 47%). A similar pattern was observed when the drug was added at 6 HPI or 42 HPI but not at 0 HPI. Cinematographic analysis revealed that alpha-amanitin increased the first cell cycle duration whereas the second and third cell cycles were not affected. With the drug, one third of the embryos could develop up to the 9- to 16-cell stage and they all had a short fourth cell cycle (11.2 +/- 3.7 h) with a good synchrony of cleavage between blastomeres. These results suggest that duration of the fourth cell cycle of bovine embryo, during the MZT, is under a zygotic transcriptional control that can be affected by oxidative conditions. [less ▲]

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See detailLa géographie appliquée à l’université de Liège
Binard, Marc ULg; Devillet, Guénaël ULg; Erpicum, Michel ULg

in Bulletin de la Société Géographique de Liège (2003), 43

Historic of the applied geography within the various units of the Geographic Department of the University of Liège (Belgium)

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