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See detailThe prefix be-/bi- as a marker of verbs of deception in late Old and early Middle English
Petré, Peter ULg

in BELL. Belgian Journal of English Language and Literatures (2006), 4

This article brings to light a productive inseparable prefix construction marked by be-/biin late Old English and early Middle English, which forms complex verbs of DECEPTION, such as betray, beguile ... [more ▼]

This article brings to light a productive inseparable prefix construction marked by be-/biin late Old English and early Middle English, which forms complex verbs of DECEPTION, such as betray, beguile, bewray. The expression of such a specific psychological sense through a verbal prefix is highly exceptional for Germanic languages, and a complex four stage development has to be assumed, starting from other concrete constructions marked by be-/bi- such as the PRIVATIVE construction (cf. bereave, behead). By emphasizing the relevance of the notion of construction in this development, the article also contributes to the insights in the relationship between constructions and language change. [less ▲]

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See detailA framework for an optimised groundwater monitoring network and aggregated indicators
Rentier, Céline; Delloye, Francis; Brouyère, Serge ULg et al

in Environmental Geology (2006), 50(2), 194-201

The implementation of the Water Framework Directive (EU 2000) requires a groundwater quality monitoring. It is used for characterisation of the 'good' chemical status of each groundwater body and for the ... [more ▼]

The implementation of the Water Framework Directive (EU 2000) requires a groundwater quality monitoring. It is used for characterisation of the 'good' chemical status of each groundwater body and for the restoration or protection purposes of those bodies already at 'good' status. Interpretative aspects are lying in the design of monitoring network and in the way of building global indicators. Attention is given here to the global chemical status of the groundwater bodies and to the role of diffuse pollution, much of which is brought via groundwater to surface water. Monitoring 'local' pollution associated with individual sites is not addressed. Groundwater bodies with different contrasted hydrogeology conditions, land use and topography have been considered to establish an approach for choosing an optimised monitoring network. Then, a quality assessment system has been developed and applied for qualifying the general status of each groundwater body. The use of non-dimensional indexes allows us to process with all kinds of chemical parameters in a normalised way and, by means of adequate aggregation rules, to qualify the general quality status of a groundwater body. The obtained diagnostic, even if not fully validated, is closely linked to the pragmatic objectives contained in the EU Water Directive. [less ▲]

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See detailPour saluer Hubert Nyssen
Durand, Pascal ULg

in Durand, Pascal (Ed.) L'écrivain et son double. Hubert Nyssen (2006)

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See detailFirst practical implementation of the component method to joints in tubular construction
Weynand, K.; Busse, E.; Jaspart, Jean-Pierre ULg

in Proceedings of the 11th International Symposium on Tubular Structures (2006)

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See detailA new species of Jonesiobryum (Bryopsida : Rhachitheciaceae) from Uganda
Fischer, E.; Killmann, D.; Sérusiaux, Emmanuel ULg

in Journal of Bryology (2006), 28(3), 177-181

Jonesiobryum dumboi is described as a new moss species from Uganda. It differs from its congeners by possessing more broadly obovate leaves and a costa that ends well below the apex. The species is only ... [more ▼]

Jonesiobryum dumboi is described as a new moss species from Uganda. It differs from its congeners by possessing more broadly obovate leaves and a costa that ends well below the apex. The species is only known from the type locality where it was collected on branches in the canopy. [less ▲]

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See detailInfluence of the shaping effect on hardness homogeneity by Vickers indentation analysis
Guillaume, Bernard ULg; Boschini, Frédéric ULg; Rulmont, André ULg et al

in Journal of the European Ceramic Society (2006), 26(15), 3191-3196

In this study, indentation technique (Vickers indentation) has been unconventionally used to evaluate the homogeneity of barium zirconate ceramic samples which have been shaped through different routes ... [more ▼]

In this study, indentation technique (Vickers indentation) has been unconventionally used to evaluate the homogeneity of barium zirconate ceramic samples which have been shaped through different routes. Statistical tools have been used to estimate the con-elation which can be established between heterogeneities within the samples and their shaping ways. (c) 2005 Elsevier Ltd. All rights reserved. [less ▲]

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See detailPrimary sarcoma of an abdominal aortic aneurysm
Defawe, O.D.; Thiry, Albert ULg; Lapiere, C.M. et al

in Abdominal Imaging (2006), 31(1, Jan-Feb), 117-119

Primary tumors of the aorta are extremely rare and the diagnosis is made most often after surgery or autopsy. Because clinical symptoms of abdominal sarcoma are similar to those of occlusive or aneurysmal ... [more ▼]

Primary tumors of the aorta are extremely rare and the diagnosis is made most often after surgery or autopsy. Because clinical symptoms of abdominal sarcoma are similar to those of occlusive or aneurysmal disease, aortic sarcomas are frequently mistaken for these lesions. The imaging findings are frequently nonspecific and therefore do not allow a definitive preoperative diagnosis. We report a case of an epithelioid angiosarcoma in the vessel wall of an abdominal aortic aneurysm. [less ▲]

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See detailMise au point d'une hyperferritinémie
Delwaide, Jean ULg; Giet, Didier ULg; Lamproye, Anne ULg et al

in Revue Médicale de Liège (2006), 61(5-6), 329-333

Hemochromatosis is the most common genetic disorder in persons of northern European descent, and the majority of cases are caused by a mutation in the gene HFE. Genetic testing for hemochromatosis is ... [more ▼]

Hemochromatosis is the most common genetic disorder in persons of northern European descent, and the majority of cases are caused by a mutation in the gene HFE. Genetic testing for hemochromatosis is therefore indicated in all patients with increases in transferrine saturation and ferritin levels. When this genetic testing does not demonstrate a hemochromatosis, other diseases responsible for elevated ferritin levels have to be ruled out, mainly hemolytic anemia, chronic inflammatory disorders, liver diseases such as hepatitis B or C, alcohol abuse, and non alcoholic fatty liver disease. In demonstrated iron overload with absence of classic causes, second-line genetic testing should be considered. [less ▲]

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See detailLa résolution de problèmes : analyse des pratiques de classe au cycle 5-8
Fagnant, Annick ULg; Hindryckx, Geneviève ULg

in Actes du 4e congrès des chercheurs en éducation : le point sur la recherche en éducation en Communauté française (2006)

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See detailCombination therapy versus monotherapy: a randomised pilot study on the evolution of inflammatory parameters after ventilator associated pneumonia
Damas, Pierre ULg; Garweg, Christophe ULg; Monchi, Mehran et al

in Critical Care (2006), 10(2), 52

Introduction Combination antibiotic therapy for ventilator associated pneumonia (VAP) is often used to broaden the spectrum of activity of empirical treatment. The relevance of such synergy is commonly ... [more ▼]

Introduction Combination antibiotic therapy for ventilator associated pneumonia (VAP) is often used to broaden the spectrum of activity of empirical treatment. The relevance of such synergy is commonly supposed but poorly supported. The aim of the present study was to compare the clinical outcome and the course of biological variables in patients treated for a VAP, using a monotherapy with a beta-lactam versus a combination therapy. Methods Patients with VAP were prospectively randomised to receive either cefepime alone or cefepime in association with amikacin or levofloxacin. Clinical and inflammatory parameters were measured on the day of inclusion and thereafter. Results Seventy-four mechanically ventilated patients meeting clinical criteria for VAP were enrolled in the study. VAP was microbiologically confirmed in 59 patients (84%). Patients were randomised to receive cefepime (C group, 20 patients), cefepime with amikacin (C-A group, 19 patients) or cefepime with levofloxacin (C-L group, 20 patients). No significant difference was observed regarding the time course of temperature, leukocytosis or C-reactive protein level. There were no differences between length of stay in the intensive care unit after infection, nor in ventilator free days within 28 days after infection. No difference in mortality was observed. Conclusion Antibiotic combination using a fourth generation cephalosporin with either an aminoside or a fluoroquinolone is not associated with a clinical or biological benefit when compared to cephalosporin monotherapy against common susceptible pathogens causing VAP. [less ▲]

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See detailNo accelerated rate of protein evolution in male-biased Drosophila pseudoobscura genes.
Metta, Muralidhar ULg; Gudavalli, Rambabu; Gibert, Jean-Michel et al

in Genetics (2006), 174(1), 411-20

Sexually dimorphic traits are often subject to diversifying selection. Genes with a male-biased gene expression also are probably affected by sexual selection and have a high rate of protein evolution. We ... [more ▼]

Sexually dimorphic traits are often subject to diversifying selection. Genes with a male-biased gene expression also are probably affected by sexual selection and have a high rate of protein evolution. We used SAGE to measure sex-biased gene expression in Drosophila pseudoobscura. Consistent with previous results from D. melanogaster, a larger number of genes were male biased (402 genes) than female biased (138 genes). About 34% of the genes changed the sex-related expression pattern between D. melanogaster and D. pseudoobscura. Combining gene expression with protein divergence between both species, we observed a striking difference in the rate of evolution for genes with a male-biased gene expression in one species only. Contrary to expectations, D. pseudoobscura genes in this category showed no accelerated rate of protein evolution, while D. melanogaster genes did. If sexual selection is driving molecular evolution of male-biased genes, our data imply a radically different selection regime in D. pseudoobscura. [less ▲]

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See detailQuantitative ultrasonography for the noninvasive assessment of equine bone: a review
Carstanjen, B.; Gabriel, Annick ULg

in IPPOLOGIA (2006), 17(4), 11-15

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See detailMorphometric study of the equine fetlock and coffin joints
Riccio, Barbara; Carstanjen, Bianca; Denoix, Jean-Marie et al

in Italian Journal of Anatomy and Embryology (2006), 111

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See detailEpidémiosurveillance des événements rares chez les bovins en Belgique
Saegerman, Claude ULg

in Annales de Médecine Vétérinaire (2006), 150(Sp. Iss. SI), 4-9

Epidémiosurveillance des événements rares chez les bovins en Belgique. Thèse de doctorat en sciences vétérinaires défendue le 29 septembre 2004.

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See detailTranscriptome analysis reveals link between proteasomal and mitochondrial pathways in Parkinson's disease.
Duke, D. C.; Moran, L. B.; Kalaitzakis, M. E. et al

in Neurogenetics (2006), 7(3), 139-48

There is growing evidence that dysfunction of the mitochondrial respiratory chain and failure of the cellular protein degradation machinery, specifically the ubiquitin-proteasome system, play an important ... [more ▼]

There is growing evidence that dysfunction of the mitochondrial respiratory chain and failure of the cellular protein degradation machinery, specifically the ubiquitin-proteasome system, play an important role in the pathogenesis of Parkinson's disease. We now show that the corresponding pathways of these two systems are linked at the transcriptomic level in Parkinsonian substantia nigra. We examined gene expression in medial and lateral substantia nigra (SN) as well as in frontal cortex using whole genome DNA oligonucleotide microarrays. In this study, we use a hypothesis-driven approach in analysing microarray data to describe the expression of mitochondrial and ubiquitin-proteasomal system (UPS) genes in Parkinson's disease (PD). Although a number of genes showed up-regulation, we found an overall decrease in expression affecting the majority of mitochondrial and UPS sequences. The down-regulated genes include genes that encode subunits of complex I and the Parkinson's-disease-linked UCHL1. The observed changes in expression were very similar for both medial and lateral SN and also affected the PD cerebral cortex. As revealed by "gene shaving" clustering analysis, there was a very significant correlation between the transcriptomic profiles of both systems including in control brains. Therefore, the mitochondria and the proteasome form a higher-order gene regulatory network that is severely perturbed in Parkinson's disease. Our quantitative results also suggest that Parkinson's disease is a disease of more than one cell class, i.e. that it goes beyond the catecholaminergic neuron and involves glia as well. [less ▲]

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See detailComparative study of commercially available anti-alpha-synuclein antibodies.
Croisier, E.; MRes, D Elfant; Deprez, Manuel ULg et al

in Neuropathology & Applied Neurobiology (2006), 32(3), 351-6

Immunohistochemistry for alpha-synuclein has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy (http://www.ICDNS ... [more ▼]

Immunohistochemistry for alpha-synuclein has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy (http://www.ICDNS.org). Nevertheless, no standardised protocol has been proposed. We have reviewed 242 of the 270 studies published until June 2005 that mentioned immunohistochemistry for anti-alpha synuclein on human tissue and we found that only 75 (31%) used commercial antibodies. We also noted that protocols, particularly dilution and antigen unmasking, varied between studies, even when the same antibody was employed. In order to establish a standardised protocol for alpha-synuclein immunohistochemistry, which can be applied in diagnostic neuropathology we tested seven commercial monoclonal antibodies in brains of subjects with Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, multiple sclerosis with incidental Lewy bodies and aged-matched normal brain and determined for each antibody the best suited protocol for antigen unmasking. We evaluated the intensity of immunolabelling in Lewy bodies, neuropil threads, dendrites, pre-synaptic terminals, granular cytoplasmic positivity, peri-axonal positivity, glial inclusions and non-specific immunolabelling. Although our results showed that all the antibodies detected alpha-synuclein inclusions, differences were noted between antibodies, particularly with regard to the detection of glial inclusions. From our study, the best antibodies of the seven tested appeared to be those directed against amino acids 116-131 and 15-123 and we suggest them to be used in routine diagnostic practice for alpha-synucleinopathies. [less ▲]

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See detailLes méthodes diagnostiques en dentisterie restauratrice et prophylactique: Evolution des outils de détection des lésions carieuses pour un diagnostic précoce
Gueders, Audrey ULg; Geerts, Sabine ULg

in Journal du dentiste (2006), 338

La mise sur le marché de nouveaux outils de diagnostic permet la détection plus précoce du processus carieux de déminéralisation. Ce présent article fait le point sur le diagnostic de la carie et sur les ... [more ▼]

La mise sur le marché de nouveaux outils de diagnostic permet la détection plus précoce du processus carieux de déminéralisation. Ce présent article fait le point sur le diagnostic de la carie et sur les outils actuellement disponibles pour améliorer nos diagnostics et intercepter plus tôt le phénomène de déminéralisation. [less ▲]

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See detailExpression of matrix metalloproteinase-2 and mutant p53 is increased in hydatidiform mole as compared with normal placenta
Petignat, P.; Laurini, R.; Goffin, Frédéric ULg et al

in International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society (2006), 16(4, JUL-AUG), 1679-1684

Matrix metalloproteinases (MMPs) are group of enzymes thought to play an important role in trophoblastic and tumor invasion. The aim of our study was to investigate the trophoblastic expression of MMPs ... [more ▼]

Matrix metalloproteinases (MMPs) are group of enzymes thought to play an important role in trophoblastic and tumor invasion. The aim of our study was to investigate the trophoblastic expression of MMPs and p53 in normal trophoblast and hydatidiform moles (HM). Paraffin sections of 45 specimens, including 14 complete hydatidiform moles (CM), 15 partial hydatidiform moles (PM), 8 atypical partial hydatidiform moles (aPM), and 8 controls were selected. Classification of HM was established on histologic criteria and supported by the DNA ploidy results. Tissue sections from each case were immunostained with monoclonal antibodies, cytokeratin-7, MMP-2, MMP-9, tissue inhibitors of metalloproteinases (TIMP)-1, and p53 wild type (p53wt) and mutant types (mutp53). Staining for cytokeratin-7 revealed a positive reaction in 93% of the samples. MMP-2 was mainly expressed in the syncytiotrophoblast of HM and found in 62% of aPM, 60% PM, and 93% CM. The mutp53 was mainly and focally expressed in syncytiotrophoblastic cells and was found in 63% of aPM, 80% PM, and 93% CM. Expression of MMP-2 and mutp53 was both significantly greater in HM vs control group (P < 0.05) and greater in CM vs PM and aPM (P < 0.05). No significant difference was observed for cytokeratin-7, MMP-9, TIMP-1, and p53wt between the HM subgroups and between HM and control group. MMP-2 and mutp53 are overexpressed in HM as compared with normal trophoblast and might participate in the invasive behavior of the HM. [less ▲]

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See detailLes interactions entre l’économie sociale et la responsabilité sociale des entreprises. Illustration à travers la filière du commerce équitable
Huybrechts, Benjamin ULg; Mertens de Wilmars, Sybille ULg; Xhauflair, Virginie ULg

in Gestion : Revue Internationale de Gestion (2006), 31(2), 65-74

L’étude de la responsabilité sociale des entreprises (RSE) cherche à analyser les démarches volontaires dans lesquelles des entreprises à but de lucre s'engagent afin de respecter, au-delà de leur ... [more ▼]

L’étude de la responsabilité sociale des entreprises (RSE) cherche à analyser les démarches volontaires dans lesquelles des entreprises à but de lucre s'engagent afin de respecter, au-delà de leur objectif de rentabilité économique, des exigences sociales et environnementales, et d’améliorer les relations avec toutes les parties concernées par leurs activités (Bender et Pigeyre, 2003). Ces initiatives rappellent des pratiques à l'œuvre depuis plus d'un siècle dans les organisations d'économie sociale (OES), qui essayent d'atteindre des objectifs sociétaux par le biais d'une activité économique (Defourny et Develtere, 1999). Si, à la suite de Levi (1998), on place les entreprises privées "classiques" et les OES aux extrémités d'un continuum qui s'étendrait de la "performance économique" à la "performance sociétale", on peut émettre l'hypothèse selon laquelle l'apparition de la RSE provoque un double mouvement. D'une part, les entreprises privées recherchent une certaine performance sociétale et, d'autre part, les OES visent davantage de performance économique en adoptant parfois un comportement plus typiquement commercial (Weisbrod, 1998). En conséquence, alors que les rôles respectifs des différentes catégories d’acteurs semblaient clairement définis, les frontières se font à présent plus floues et certains domaines d’activité sont indubitablement témoins d’un rapprochement entre le secteur privé "classique" et le secteur de l'économie sociale. Néanmoins, ces deux ensembles ne semblent pas mus l’un vers l’autre de manière endogène et autonome : au contraire, il y a lieu de penser que les évolutions respectives sont le fruit d’influences réciproques. Notre article a pour but de faire le point sur cette hypothèse de rapprochement, en partant des rôles traditionnels des institutions au sein du système socio-économique et en observant de quelle manière le monde des entreprises et celui de l’économie sociale se sont non seulement rapprochés, mais également influencés réciproquement. Notre réflexion est structurée en trois étapes. Tout d'abord, nous présentons brièvement le contenu que nous associons aux deux concepts principaux sur lesquels repose notre argumentation (l'économie sociale et la RSE) et nous nous basons sur les arguments de la théorie économique institutionnelle pour identifier les atouts respectifs et les rôles traditionnellement dévolus aux grandes catégories d'acteurs dans nos économies. Dans un deuxième temps, nous montrons pourquoi on peut considérer la rencontre entre les OES et les entreprises à but de profit comme un des stimuli du mouvement de RSE et combien ces interactions peuvent potentiellement transformer les comportements de ces deux types d'acteurs. Enfin, nous illustrons notre hypothèse par une analyse des interactions entre OES et entreprises en quête de responsabilité sociale dans la filière du commerce équitable et éthique. Pour ce faire, nous nous basons principalement sur une étude empirique exploratoire menée sur la scène équitable belge et portant sur ces interactions et leurs conséquences en termes de gestion de l’activité économique (Huybrechts et Mertens, 2006). [less ▲]

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See detailCytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Colorectal Peritoneal Carcinomatosis : Higher Complication Rate for Oxaliplatin Compared to Mitomycin C
Rouers, A.; Laurent, S.; Detroz, Bernard ULg et al

in Acta Chirurgica Belgica (2006), 106

Peritoneal carcinomatosis (PC) from colo-rectal cancer carries a very poor prognosis with a mean and median overall survival times of 6.9 and 5.2 months. It has been proved that a locoregional therapeutic ... [more ▼]

Peritoneal carcinomatosis (PC) from colo-rectal cancer carries a very poor prognosis with a mean and median overall survival times of 6.9 and 5.2 months. It has been proved that a locoregional therapeutic approach of this disease with cytoreduction followed by hyperthermic intraperitoneal chemotherapy (HIPEC) improved survival of these patients. However, this combined treatment presents a high complication rate. Methods : 21 patients with PC of colorectal origin underwent complete cytoreduction followed by HIPEC using Mitomycin-C (13 patients) or oxaliplatin (8 patients) and the open coliseum technique. For each case the medical datas were retrospectively analysed to determine feasibility, morbidity, mortality, survival time and prognostic factors. Results : All patients presented a Sugarbaker’s Peritoneal Cancer index inferior to 15. The mean operating time was 453 minutes. After a median follow-up of 24.9 months, actuarial disease-free survival was 36.6% at 5 years. The median survival time was 34 months. The morbidity rate was 33.3% with a significant higher complication rate in the oxaliplatin group (5/8) than in the Mytomycin-C (MMC) group (2/13). One patient (4.7%) died two months after treatment with MMC (endocarditis). Conclusions : This series confirm positive impact of cytoreduction and HIPEC on PC. We obtained a moderated complications rate thanks to a high degree of selection of the patient. Oxaliplatin scheme is responsible of a higher morbidity than in MMC group. Phase III trial comparing these two drugs is needed. [less ▲]

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