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See detailVers une gestion intégrée et participative de la forêt? L'exemple de la commune de Nassogne
Lejeune, Philippe ULg; Claessens, Hugues ULg; Alderweireld, Matthieu ULg et al

in Forêt Wallonne (2007), (86), 11-23

Un projet pilote de gestion intégrée et participative d’un massif forestier est en cours depuis 1998 sur une étendue de 20 000 hectares au plateau de Saint-Hubert. En quoi consiste une telle démarche ... [more ▼]

Un projet pilote de gestion intégrée et participative d’un massif forestier est en cours depuis 1998 sur une étendue de 20 000 hectares au plateau de Saint-Hubert. En quoi consiste une telle démarche ? Quel est son intérêt ? Comment se différencie-t-elle d’un aménagement classique ? Voici, entre autres, les questions auxquelles cet article tente de répondre à partir de l’exemple de la révision de l’aménagement de la propriété forestière communale de Nassogne. [less ▲]

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See detailA prospective randomised multicentre study comparing continuous and intermittent treatment with celecoxib in patients with osteoarthritis of the knee or hip
Luyten, F. P.; Geusens, P.; Malaise, Michel ULg et al

in Annals of the Rheumatic Diseases (2007), 66(1), 99-106

Objective: To compare the effects of continuous and intermittent celecoxib treatment in patients with knee or hip osteoarthritis in flare. Methods: In this 24-week, prospective, randomised, double-blind ... [more ▼]

Objective: To compare the effects of continuous and intermittent celecoxib treatment in patients with knee or hip osteoarthritis in flare. Methods: In this 24-week, prospective, randomised, double-blind, placebo-controlled study, patients were randomly assigned to receive continuous (n = 62) or intermittent (n = 61) treatment with celecoxib 200 mg once daily. The primary efficacy end point was the area under the curve (AUC) of the change in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total scores between baseline and week 24 divided by the time interval. Secondary end points included the percentage of days with intake of the flare drug, the AUC of the change in the WOMAC total scores, the mean change from baseline in the WOMAC scores, and the patient's and physician's global assessment of osteoarthritis. Results: There were no significant differences between patients randomised to continuous or intermittent treatment in the primary end point or most of the secondary end points, although a consistent trend supporting continuous treatment was observed. The percentage of days with intake of the flare drug was significantly lower (p = 0.031) in the group receiving continuous versus intermittent celecoxib. Both treatment regimens were well tolerated. Conclusion: The results of this pilot study indicate a potential clinical difference between continuous and intermittent treatment with celecoxib, and may be useful in designing future trials. A larger trial on both efficacy and safety outcomes is required for conclusive evidence in favour of either continuous or intermittent treatment. [less ▲]

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See detailLe traitement de la pericardite recidivante: a propos d'un cas et revue de la litterature
Martin y Porras, M.; Waleffe, André ULg; Pierard, Luc ULg

in Revue Médicale de Liège (2007), 62(1), 21-4

Benign acute pericarditis is a common disorder. Recurrence is probably the most troublesome complication, characterized by a return of pericardial pain after recovery from an episode of typical acute ... [more ▼]

Benign acute pericarditis is a common disorder. Recurrence is probably the most troublesome complication, characterized by a return of pericardial pain after recovery from an episode of typical acute pericarditis. Treatment of recurrence is often difficult and the guidelines issued by scientific societies remain vague. A number of investigators published enthusiastic reports on the efficacy of colchicine as adjuvant treatment of recurrent pericarditis and other authors suggested that colchicine should also be used as part of the treatment regimen of acute pericarditis. Colchicine is effective and safe and may be proposed as treatment of choice, especially in the idiopathic form. Treatment with corticosteroids exacerbates and extends the course of recurrent pericarditis and attenuates the efficacy of colchicine. [less ▲]

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See detailSolutions imaginées par les enseignants en éducation physique du secondaire pour lutter contre le phénomène de la dispense dans le cours de natation
Motter, Pascale; Maraite, Anne-Aymone ULg; Cloes, Marc ULg

in e Journal de la Recherche sur l'Intervention en Éducation Physique et Sport (2007), 11

En Communauté française de Belgique, les professeurs d’éducation physique de l’enseignement secondaire sont actuellement confrontés à une augmentation du nombre d’élèves cherchant à ne pas participer à ... [more ▼]

En Communauté française de Belgique, les professeurs d’éducation physique de l’enseignement secondaire sont actuellement confrontés à une augmentation du nombre d’élèves cherchant à ne pas participer à leurs cours. Ce phénomène atteint des proportions particulièrement préoccupantes dans les cours de natation, avec les classes de filles. Cette étude s’intéresse aux pistes d’actions expérimentées par 50 enseignantes qui ont été interviewées par téléphone. Les réponses ont été classées inductivement dans un système de catégories avec un taux de 97,2% d’accords intra-analystes. Trois types de solutions ont été identifiées : (1) celles qui ont donné des résultats positifs ; (2) celles qui se sont montrées inefficaces et (3) celles que les sujets souhaiteraient tester. Parmi les premières (n = 46), les actions les plus fréquentes se répartissent entre une catégorie coercitive (« menaces/sanctions ») et une catégorie constructive (« Contenu des séances »). Plusieurs autres pistes originales sont discutées. Les solutions s’étant montrées inefficaces s’avèrent étonnamment similaires aux précédentes, mettant en exergue l’extrême variabilité des effets des stimuli pédagogiques. Enfin, il est encourageant de constater que certains enseignants se mobilisent afin de résoudre les problèmes rencontrés sur le terrain. Deux exemples de solutions à expérimenter ont ainsi été identifiés et discutés. [less ▲]

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See detailPreconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: implications for anti-cancer therapies
Martinive, Philippe ULg

Poster (2007, January)

Hypoxia is a common feature in tumors associated with an increased resistance of tumor cells to therapies. In addition to O(2) diffusion-limited hypoxia, another form of tumor hypoxia characterized by ... [more ▼]

Hypoxia is a common feature in tumors associated with an increased resistance of tumor cells to therapies. In addition to O(2) diffusion-limited hypoxia, another form of tumor hypoxia characterized by fluctuating changes in pO(2) within the disorganized tumor vascular network is described. Here, we postulated that this form of intermittent hypoxia promotes endothelial cell survival, thereby extending the concept of hypoxia-driven resistance to the tumor vasculature. We found that endothelial cell exposure to cycles of hypoxia reoxygenation not only rendered them resistant to proapoptotic stresses, including serum deprivation and radiotherapy, but also increased their capacity to migrate and organize in tubes. By contrast, prolonged hypoxia failed to exert protective effects and even seemed deleterious when combined with radiotherapy. The use of hypoxia-inducible factor-1alpha (HIF-1alpha)-targeting small interfering RNA led us to document that the accumulation of HIF-1alpha during intermittent hypoxia accounted for the higher resistance of endothelial cells. We also used an in vivo approach to enforce intermittent hypoxia in tumor-bearing mice and found that it was associated with less radiation-induced apoptosis within both the vascular and the tumor cell compartments (versus normoxia or prolonged hypoxia). Radioresistance was further ascertained by an increased rate of tumor regrowth in irradiated mice preexposed to intermittent hypoxia and confirmed in vitro using distinctly radiosensitive tumor cell lines. In conclusion, we have documented that intermittent hypoxia may condition endothelial cells and tumor cells in such a way that they are more resistant to apoptosis and more prone to participate in tumor progression. Our observations also underscore the potential of drugs targeting HIF-1alpha to resensitize the tumor vasculature to anticancer treatments. PMID: 17178869 [PubMed - indexed for MEDLINE] [less ▲]

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See detailThird Belgian multicentre survey of antibiotic susceptibility of anaerobic bacteria
Wybo, Ingrid; Piérard, Denis ULg; Verschraegen, Inge et al

in Journal of Antimicrobial Chemotherapy (2007), 59(1), 132-139

Objectives: To collect recent data on the susceptibility of anaerobes and to compare them with results from previous studies. Methods: Four hundred and forty-three anaerobic clinical isolates from various ... [more ▼]

Objectives: To collect recent data on the susceptibility of anaerobes and to compare them with results from previous studies. Methods: Four hundred and forty-three anaerobic clinical isolates from various body sites were prospectively collected from October 2003 to February 2005 in nine Belgian hospitals. MICs were determined for nine anti-anaerobic and three recently developed antibiotics. Results: Most Gram-negative bacilli except Fusobacterium spp. were resistant to penicillin. Piperacillin/tazobactam, metronidazole, chloramphenicol, meropenem and amoxicillin/clavulanic acid were very active against all groups, but only 86% of Bacteroides fragilis group strains were susceptible to the latter. Cefoxitin, cefotetan and clindamycin were less active. In particular, only 62%, 52% and 48% of B. fragilis group strains were susceptible, respectively. Clindamycin shows a continuing decrease in activity, as 83% were still susceptible in 1987 and 66% in 1993-94. Anti-anaerobic activity of the new antibiotics is interesting, with MIC50 and MIC90 of 1 and > 32 mg/L for moxifloxacin, 2 and 4 mg/L for linezolid and 0.5 and 8 mg/L for tigecycline. Conclusions: The susceptibility of anaerobic bacteria remains stable in Belgium, except for clindamycin, which shows a continuous decrease in activity. However, for each of the tested antibiotics, at least a few resistant organisms were detected. Consequently, for severe infections involving anaerobic bacteria, it could be advisable to perform microbiological testing instead of relying on known susceptibility profiles. Periodically monitoring background susceptibility remains necessary to guide empirical therapy. [less ▲]

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See detailUne déontologie manipulée ?
Durand, Pascal ULg; Grégoire, Arnaud

Article for general public (2007)

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See detailMiroir interne déformant de l'image de soi : élaboration conceptuelle intégrant la clinique et les découvertes récentes des neurosciences
Scholl, Jean-Marc ULg; Philippe, Paule ULg

Poster (2007, January)

Neurosciences : Un réseau neuronal spécifiquement référé au "self" du sujet est mis en évidence en neuroimagerie (Ph Fossati). Il intervient pour se remémore des attributs référés au self. Ce réseau est ... [more ▼]

Neurosciences : Un réseau neuronal spécifiquement référé au "self" du sujet est mis en évidence en neuroimagerie (Ph Fossati). Il intervient pour se remémore des attributs référés au self. Ce réseau est différent de celui qui permet au sujet de donner des attributs à d'autres individus. Le réseau référé au self permet d'être en contact immédiat avec l'image et la connaissance de soi. De plus, le rappel mnésique des attributs positifs et négatifs référés au self met en jeu des réseaux neuronaux différents. Les attributs positifs référés au self activent la région préfrontale antéromédiane droite, les attributs négatifs référés au self la région préfrontale dorsolatérale droite. Le sujet sain active les deux réseaux de façon simultanée pour restituer une image de soi intégrée. Définition conceptuelle: Le "miroir interne" – distingué de l'objet qui lui est présenté – correspond¬ au réseau neuronal référé spécifiquement au self. Ce réseau accède à l'image de soi. S'il y a un dysfonctionnement du réseau référé au self, il restitue une image déformée de soi, et le "miroir interne" devient déformant. Le sujet associera son identité à cette image déformée. Clinique du «miroir interne déformant de l'image de soi» : Le regard de l'enfant sur lui-même lui renvoie une image plus négative que ce que ses interlocuteurs ne perçoivent de lui. Dès le départ, l'enfant a une mauvaise perception de lui-même. Lorsqu'un interlocuteur lui fait une remarque, l'enfant bascule dans une image déformée et bien plus négative que celle que ne lui prête l'interlocuteur. Un dysfonctionnement de ces réseaux déséquilibre la balance et ne fait apparaître "qu'une seule couleur" dans le "miroir interne" par une restitution mnésique univoque : ou des attributs positifs, ou des attributs négatifs. Une prépondérance de l'image négative évoque un terrain dépressif, des personnalités évitante ou dépendante. Une prépondérance de l'image positive évoque des personnalités narcissiques, une image mégalomaniaque. Un dysfonctionnement neuronal peut induire une labilité et une instabilité de cette image (borderline), ou, une bascule rapide en "on-off" d'images positives et négatives de soi (rencontrée en pédopsychiatrie). Une psychoéducation permet la prise de conscience de ce miroir interne déformant. [less ▲]

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See detailCutting planes from lattice-point-free polyhedra
Louveaux, Quentin ULg

Conference (2007, January)

In this talk, we generalize the concept of a split (that leads to split cuts) to any lattice-point-free polyhedron. We show how we can generate cutting planes for a polyhedron from these objects ... [more ▼]

In this talk, we generalize the concept of a split (that leads to split cuts) to any lattice-point-free polyhedron. We show how we can generate cutting planes for a polyhedron from these objects. Associated to any lattice-point-free polyhedron, we define a "split-dimension" (which is equal to 1 in the case of a split in the usual sense). We then consider the operation of adding to a polyhedron all cutting planes that we can obtain from considering all the lattice-point-free polyhedra with a split-dimension lower or equal to d. We call the obtained object the "d-dimensional split closure" of the initial polyhedron. We discuss whether this object is again a polyhedron or not. As an important illustration, we focus on objects of split-dimension equal to 1 or 2. [less ▲]

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See detailA novel 24-base pair deletion in the coding region of CCR5 in an African population
Karasi, Jean Claude ULg

in AIDS (2007), 21(1), 111-113

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See detailLe depistage du cancer colorectal
Piront, Patricia ULg; Louis, Edouard ULg; Belaiche, Jacques ULg et al

in Revue Médicale de Liège (2007), 62(1), 15-20

Colorectal cancer is the second leading cause of death in Northern countries and need a national screening program to reduce mortality and improve quality of life. Screening has to be cost-effective and ... [more ▼]

Colorectal cancer is the second leading cause of death in Northern countries and need a national screening program to reduce mortality and improve quality of life. Screening has to be cost-effective and acceptable for patients. Many screening tools, invasive or not, are existing and often debated: FOBT, sigmoidoscopy and complete colonoscopy. New tools are in development and have to be evaluated in current practice: virtual colonoscopy, new endoscopic technologies, DNA on faeces or proteomics with markers in serum. [less ▲]

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See detailAllo maman ici bébé: les technologies de la reproduction chez les équidés
Ponthier, Jérôme ULg; Deleuze, Stefan ULg

Article for general public (2007)

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See detailThe contribution of processing fluency to preference : a comparison with familiarity-based recognition
Willems, Sylvie ULg; Van der Linden, Martial ULg; Bastin, Christine ULg

in European Journal of Cognitive Psychology (2007), 19(1), 119-140

There is a great deal of evidence supporting the idea that, when a stimulus is processed fluently, it is more likely to be judged as pleasant. However, this influence of fluency on preference judgement ... [more ▼]

There is a great deal of evidence supporting the idea that, when a stimulus is processed fluently, it is more likely to be judged as pleasant. However, this influence of fluency on preference judgement seems to depend on several experimental conditions. So we tried to better understand these conditions via a comparison with recognition and by manipulating some aspects of the procedure (test format) and material (similarity and figure-ground contrast of the stimuli). Two experiments showed that some conditions maximally induce the use of processing fluency in a preference judgement, as in a recognition task. We discuss the implications of these findings for the well-documented discrepancy-attribution hypothesis (Whittlesea [less ▲]

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See detailNew Kids on the Blogs
Dejasse, Erwin ULg; Paques, Frédéric ULg

in Neuvième art 2.0. (2007), 13

The article deals with of the phenomenon of Comic Blogs

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See detailLe lycée Léonie de Waha
Charlier, Sébastien ULg

in Nouvelles du Patrimoine (Les) (2007), 115

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See detailMise en place de l’autocontrôle : ce que cela implique dans vos exploitations
Belleflamme, Christel ULg; Di Tanna, Sybille ULg; Moerman, John et al

Article for general public (2007)

Suite à une directive européenne, la mise en place d’un système de gestion de la sécurité des denrées alimentaires est devenue obligatoire en Belgique. Outre la création de l’Agence Fédérale pour la ... [more ▼]

Suite à une directive européenne, la mise en place d’un système de gestion de la sécurité des denrées alimentaires est devenue obligatoire en Belgique. Outre la création de l’Agence Fédérale pour la Sécurité de la Chaîne Alimentaire, une législation en matière d’autocontrôle de notification obligatoire et de traçabilité a été mise en place. Les agriculteurs qui transforment et commercialisent leur production sont directement concernés. Nous vous proposons de mettre en avant quelques conséquences pratiques qui en découlent et l’encadrement proposé par Gembloux en la matière [less ▲]

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See detailMonitoring an odour in the environment with an electronic nose : requirements for the signal processing
Romain, Anne-Claude ULg; Delva, Julien ULg; Nicolas, Jacques ULg

Conference (2007, January)

Artificial olfaction system (the so-called electronic nose) is a very promising tool to monitor the malodour in the field. Usual measurement techniques of odour use human olfaction or conventional ... [more ▼]

Artificial olfaction system (the so-called electronic nose) is a very promising tool to monitor the malodour in the field. Usual measurement techniques of odour use human olfaction or conventional analytical techniques. The first category represents the real odour perception but is not applicable to measure continuously bad odours in the field. The second class of techniques gives the mixture composition but not the global information representative of the odour perception. The e-nose has the potentialities to combine "the odour perception" and the "monitoring in the field". However to be able to reach that goal, the signal processing has to be adapted to work in complex environment. The research group in Arlon has more than ten years experience in the measure of environmental malodours in the field. The paper presents the minimal requirements that the group considers as essential for artificial olfaction system to become successful for this application. [less ▲]

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See detailSufasalazine unveils a contact-independent HSV-TK/ganciclovir gene therapy bystander effect in malignant gliomas
Robe, Pierre ULg; Nguyen-Khac, Minh-Tuan ULg; Lambert, Frédéric ULg et al

in International Journal of Oncology (2007), 30(1), 283-290

The efficacy of HSV-TK/ganciclovir-based gene therapy on malignant gliomas largely relies on the amplitude of the bystander effect. In these experiments, the anti-inflammatory drug Sulfasalazine increased ... [more ▼]

The efficacy of HSV-TK/ganciclovir-based gene therapy on malignant gliomas largely relies on the amplitude of the bystander effect. In these experiments, the anti-inflammatory drug Sulfasalazine increased the HSV-TK/ganciclovir bystander effect in C6, 9L and LN18 cells but not in U87 glioma cells. Using bi-compartmental culture devices and conditioned medium transfer experiments, we showed that in C6, 9L and LN18 cells but not in U87 cells, Sulfasalazine also unveiled a new, contact-independent mechanism of HSV-TK/ganciclovir bystander effect. Upon treatment with ganciclovir, human LN18-TK but not U87-TK cells synthetized and released TNF-alpha in the culture medium. Sulfasalazine sensitized glioma cells to the toxic effect of TNF-alpha. and enhanced its secretion in LN18-TK cells in response to GCV treatment. The caspase-8 inhibitor Z-IETD-FMK and a blocking antibody to TNF-alpha both inhibited the contact-independent bystander effect in LN18 cells. Taken together, these results suggest that TNF-alpha mediates the contact-independent bystander effect in LN18 cells. The treatment with GCV and/or Sulfasalazine of tumor xenografts consisting of a mix of 98% C6 and 2% C6-TK cells shows that Sulfasalazine is also a potent adjunct to the in vivo treatment of gliomas. [less ▲]

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See detailMinimization of Production Cost by use of an Automatic Cost Assessment Method and Simulation
Caprace, Jean-David ULg; Bair, Frédéric ULg; Losseau, Nicolas ULg et al

in The Euro-Asia Maritime Network (EAMARNET) (2007, January)

This paper will present different ways to minimize cost in shipbuilding industry. Amongst them we have the production simulation methods, the cost assessment methods and the optimization methods. Nowadays ... [more ▼]

This paper will present different ways to minimize cost in shipbuilding industry. Amongst them we have the production simulation methods, the cost assessment methods and the optimization methods. Nowadays, cost assessment is a key task of an integrated ship design. The various methods to estimate the production cost differ with the known information (input data). The less information is detailed, the earlier a method can be used in the design process. The more information is used, the better we can assess the differences between design alternatives. The methods presented here and the “design for production” concept promise to increase the productivity trough the following points: a more accurate cost estimation, an improvement in the deadlines planning and the production schedule, a progress in distribution of the workload between the various production workshops, a better knowledge of the individual costs that will permit to reduce the global cost. In order to illustrate our work, we present in this paper three methods to decrease the global cost of a ship. [less ▲]

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