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See detailDes éditeurs sans édition. Genèse et structure de l’espace éditorial en Belgique francophone
Durand, Pascal ULiege; Winkin, Yves

in Actes de la Recherche en Sciences Sociales (1999), 130

L'édition n'est pas seulement un objet à étudier; elle est aussi un observatoire des pratiques culturelles. En prenant pour terrain d'analyse le marché de la production du livre en Belgique francophone ... [more ▼]

L'édition n'est pas seulement un objet à étudier; elle est aussi un observatoire des pratiques culturelles. En prenant pour terrain d'analyse le marché de la production du livre en Belgique francophone, on se donne le moyen de saisir au concret le rapport d'implication réciproque entretenu par les œuvres avec les vecteurs de leur production et de leur diffusion. Ce rapport, comme ces vecteurs, ont une histoire, particulièrement déterminante et complexe, mais aussi répétitive, dans les territoires belges. Ainsi, il est frappant de constater l’impossibilité, pour l’édition en Belgique, de lui désigner dans l’histoire un moment de naissance à partir duquel elle se serait continûment déployée. C’est, à différents moments, de naissances à répétition qu’il s’agit plutôt et donc, aussi bien, d’extinctions successives. D'où le fait qu'aucune culture éditoriale, au sens le plus littéraire de l'expression, ne se soit véritablement développée en Belgique francophone. Plantin au XVIe siècle édifie certes, à force d’énergie, d’ambition intellectuelle et d’opportunisme politico-religieux, une maison de rayonnement international, mais fait figure d’isolé, mal relayé de surcroît par ses héritiers. Les imprimeurs liégeois et bruxellois, du XVIIIe siècle aux années 1850, inondent l’Europe d’ouvrages contrefaits : ils bloquent pour longtemps le système éditorial dans des routines de reproduction et s’effondreront sous le coup de la Convention franco-belge de 1852. Au XIXe siècle, Casterman fait tourner ses presses au profit des missels et des ouvrages de dévotion : les convoyeurs de la haute littérature attendront. Dans les années 1890, quelques petits éditeurs parviennent à esquisser les contours d’une édition spécifiquement littéraire : tous font très vite faillite quand ils ne s’écroulent pas sous le poids de la censure. Il faudra attendre le nouveau Casterman et Marabout pour que se déploient en Belgique des maisons de rayonnement international, mais dans des genres dominés tels que la bande dessinée et le livre de poche industriel. Des attitudes toutefois se maintiennent, se transmettent peut-être d'une génération à l'autre. L'hypothèse conductrice de l'article est la suivante : de Plantin aux éditeurs littéraires contemporains se construit en Belgique un habitus techniciste, autrement dit une représentation de l'activité éditoriale comme fabrication de livres plutôt que comme production de biens symboliques aptes à circuler sur le marché littéraire à force égale avec ceux que la France, ayant mieux négocié le passage de l'imprimerie à l'édition, produit de son côté. Cette situation n'est pas sans présenter quelques ressources pour l'avenir. A l'heure des mouvements de concentration internationaux, il se pourrait bien en effet que les éditeurs de Belgique, comme ceux d'autres zones marginales, contribuent, du fait de leur fonctionnement apparemment "archaïque", à maintenir la possibilité d'une édition indépendante. [less ▲]

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See detailL'approche expérimentale est-elle adaptée à l'évaluation des actions d'éducation pour la santé ?
Liesse, Anne; Vandoorne, Chantal ULiege

in Education Santé (1999), (143), 5-8

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See detailLe cas clinique du mois. Le cerebral salt wasting syndrome: a propos d'un cas
Llabres, V.; Canivet, Jean-Luc ULiege; Hennuy, V. et al

in Revue Médicale de Liège (1999), 54(11), 850-853

A 75 year old woman was found to have a posterior cerebellar lesion which after surgical removal was shown to be a meningioma. Her postoperative course was complicated by a MRSA meningitis and on day 23 ... [more ▼]

A 75 year old woman was found to have a posterior cerebellar lesion which after surgical removal was shown to be a meningioma. Her postoperative course was complicated by a MRSA meningitis and on day 23 after resection, a polyuria up to 11.7 1/24 h became apparent. The diagnosis of cerebral wasting syndrome (CSWS) was made based on biological and clinical features such as an excessive natriuresis (143 mmol/l) resulting in hyponatremia (130 mmol/l) and an osmolarity higher in urine than in blood. A low central venous pressure and a low wedge pressure confirming a volumic depletion indicated the diagnosis of CSWS. This syndrome has marked similarities with the Inappropriate Secretion of Antidiuretic Hormone Syndrome (SIADH) in terms of biological finding with regards to clinical context and presentation. Without an adequate assessment, a patient with CSWS may be misdiagnosed as SIADH. However recognition is important, as water restriction which is part of SIADH treatment, is detrimental to patients with CSWS and can possibly be lethal. [less ▲]

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See detailLe sain du Sein
Focant, Jean-François ULiege

Article for general public (1999)

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See detailLa "culture médiatique" au XIXe siècle
Durand, Pascal ULiege

in Les Dossiers de l'ORM (1999), 6

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See detailAirway Mast-Cell Activation in Asthmatics Is Associated with Selective Sputum Eosinophilia
Bettiol, Jane; Radermecker, Maurice ULiege; Sele, Jocelyne ULiege et al

in Allergy (1999), 54(11), 1188-93

BACKGROUND: Tryptase is a serine endoprotease selectively released from mast cells. Although mast cells are known to be activated after experimental allergic provocation, their role in naturally occurring ... [more ▼]

BACKGROUND: Tryptase is a serine endoprotease selectively released from mast cells. Although mast cells are known to be activated after experimental allergic provocation, their role in naturally occurring asthma is still debated. METHODS: We have investigated the levels of tryptase in the whole induced sputum collected from 51 asthmatics (31 atopic and 20 intrinsic) seen in our outpatient clinic and 22 normal nonatopic healthy volunteers. Tryptase was measured by a new immunoassay based on B12 monoclonal antibody recognition of total tryptase (UniCAP System, Pharmacia) with a sensitivity of 1 ng/ml. RESULTS: While being below the threshold of detection in all normal volunteers, tryptase was detectable in the sputum from 9/51 asthmatics (18%) including five atopic and four intrinsic asthma cases. In these patients, among whom three were asymptomatic asthmatics, the values ranged between 1 and 6.1 ng/ml. The asthmatics with detectable sputum tryptase had greater sputum eosinophil counts (P<0.05) but lower neutrophil counts (P<0.05) than those in whom tryptase was undetectable. When compared to control subjects, asthmatics without tryptase had still greater eosinophil counts (P<0.0001) but also raised neutrophil counts (P<0.05). No significant difference could be found between asthmatics with tryptase and those without tryptase with respect to the age, the baseline lung function, the methacholine bronchial responsiveness, and the frequency of treatment with inhaled steroids. CONCLUSIONS: With the UniCAP System, tryptase was detectable in the sputum from 18% of asthmatics irrespective of atopy and current symptoms. Asthmatics with tryptase appeared to have a selective increase in sputum eosinophil counts while those without tryptase displayed a mixed sputum granulocyte infiltration with raised eosinophil and neutrophil counts. [less ▲]

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See detailLa PME et l'entreprise familiale
Van Caillie, Didier ULiege

Scientific conference (1999, October 29)

This seminar proposes a detailed overview of the basic management principles that are emerging when managing a SME and, more specifically, a family business. The importance of SMEs in the Belgian economy ... [more ▼]

This seminar proposes a detailed overview of the basic management principles that are emerging when managing a SME and, more specifically, a family business. The importance of SMEs in the Belgian economy, the role of the entrepreneur as an indiividual, the role of the family within the firm and key problems emerging in the day-to-day management of the firm are successively discussed. [less ▲]

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See detailLe schéma de développement de l'espace régional
Delnoy, Michel ULiege

in Immobilier (1999), 18

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See detailGravitational lensing studies with the 4-m International Liquid Mirror Telescope (ILMT)
Jean, C.; Claeskens, Jean-François ULiege; Surdej, Jean ULiege

Poster (1999, October 01)

A 4-m International Liquid Mirror Telescope (ILMT) is being built in the north of Chile by an international consortium and will become operational in two years from now. We present here a short ... [more ▼]

A 4-m International Liquid Mirror Telescope (ILMT) is being built in the north of Chile by an international consortium and will become operational in two years from now. We present here a short description of the telescope as well as estimates of the microlensing, macrolensing and weak lensing effects expected from a deep, multicolor imaging survey made with such a telescope. [less ▲]

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See detailLack of Cell Wall Peptidoglycan Versus Penicillin Sensitivity: New Insights into the Chlamydial Anomaly
Ghuysen, Jean-Marie ULiege; Goffin, Colette

in Antimicrobial Agents and Chemotherapy (1999), 43(10), 2339-2344

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See detailProposition de critères microbiologiques pour l'auto-contrôle de l'hygiène dans les abattoirs belges
Daube, Georges ULiege; Ghafir, Y.; Dumont, J.-M. et al

Poster (1999, October)

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See detailLes sensibilités territoriales
Schmitz, Serge ULiege

Doctoral thesis (1999)

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See detailThe Catalytic, Glycosyl Transferase and Acyl Transferase Modules of the Cell Wall Peptidoglycan-Polymerizing Penicillin-Binding Protein 1b of Escherichia Coli
Terrak, Mohammed ULiege; Ghosh, Tushar K.; van Heijenoort, Jean et al

in Molecular Microbiology (1999), 34(2), 350-364

The penicillin-binding protein (PBP) 1b of Escherichia coli catalyses the assembly of lipid-transported N-acetyl glucosaminyl-beta-1, 4-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-(L)-meso-diaminopimelyl ... [more ▼]

The penicillin-binding protein (PBP) 1b of Escherichia coli catalyses the assembly of lipid-transported N-acetyl glucosaminyl-beta-1, 4-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-(L)-meso-diaminopimelyl+ ++- (L)-D-alanyl-D-alanine disaccharide pentapeptide units into polymeric peptidoglycan. These units are phosphodiester linked, at C1 of muramic acid, to a C55 undecaprenyl carrier. PBP1b has been purified in the form of His tag (M46-N844) PBP1bgamma. This derivative provides the host cell in which it is produced with a functional wall peptidoglycan. His tag (M46-N844) PBP1bgamma possesses an amino-terminal hydrophobic segment, which serves as transmembrane spanner of the native PBP. This segment is linked, via an congruent with 100-amino-acid insert, to a D198-G435 glycosyl transferase module that possesses the five motifs characteristic of the PBPs of class A. In in vitro assays, the glycosyl transferase of the PBP catalyses the synthesis of linear glycan chains from the lipid carrier with an efficiency of congruent with 39 000 M-1 s-1. Glu-233, of motif 1, is central to the catalysed reaction. It is proposed that the Glu-233 gamma-COOH donates its proton to the oxygen atom of the scissile phosphoester bond of the lipid carrier, leading to the formation of an oxocarbonium cation, which then undergoes attack by the 4-OH group of a nucleophile N-acetylglucosamine. Asp-234 of motif 1 or Glu-290 of motif 3 could be involved in the stabilization of the oxocarbonium cation and the activation of the 4-OH group of the N-acetylglucosamine. In turn, Tyr-310 of motif 4 is an important component of the amino acid sequence-folding information. The glycosyl transferase module of PBP1b, the lysozymes and the lytic transglycosylase Slt70 have much the same catalytic machinery. They might be members of the same superfamily. The glycosyl transferase module is linked, via a short junction site, to the amino end of a Q447-N844 acyl transferase module, which possesses the catalytic centre-defining motifs of the penicilloyl serine transferases superfamily. In in vitro assays with the lipid precursor and in the presence of penicillin at concentrations sufficient to derivatize the active-site serine 510 of the acyl transferase, the rate of glycan chain synthesis is unmodified, showing that the functioning of the glycosyl transferase is acyl transferase independent. In the absence of penicillin, the products of the Ser-510-assisted double-proton shuttle are glycan strands substituted by cross-linked tetrapeptide-pentapeptide and tetrapeptide-tetrapeptide dimers and uncross-linked pentapeptide and tetrapeptide monomers. The acyl transferase of the PBP also catalyses aminolysis and hydrolysis of properly structured thiolesters, but it lacks activity on D-alanyl-D-alanine-terminated peptides. This substrate specificity suggests that carbonyl donor activity requires the attachment of the pentapeptides to the glycan chains made by the glycosyl transferase, and it implies that one and the same PBP molecule catalyses transglycosylation and peptide cross-linking in a sequential manner. Attempts to produce truncated forms of the PBP lead to the conclusion that the multimodular polypeptide chain behaves as an integrated folding entity during PBP1b biogenesis. [less ▲]

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See detailAspergillus fumigatus detection by PCR in broncho-alveolar fluid
Hayette, Marie-Pierre ULiege; Boland, Pascal; Evrard, Béatrice et al

Poster (1999, September 29)

Background: The usefullness of a nested PCR for detection of Aspergillus fumigatus DNA was evaluated in bronchoalveolar lavage (BAL) fluid during a period of two years (1996- 1998). The aim of the study ... [more ▼]

Background: The usefullness of a nested PCR for detection of Aspergillus fumigatus DNA was evaluated in bronchoalveolar lavage (BAL) fluid during a period of two years (1996- 1998). The aim of the study was to assess the role of PCR in diagnosing invasive pulmonary aspergillosis (IPA). Methods: A nested PCR-based amplification of fragments of genes-encoding alkaline proteases from A. fumigatus was used to test 167 BAL samples. All samples were checked for the absence of amplification inhibitors. Medical, radiological, microbiological records and autopsy findings were reviewed for assessing invasive aspergillosis. All successive patients investigated by BAL were included in the study. They were distributed in three groups: A, proven or probable aspergillosis (n=11); B, colonization (n=2); C, no evidence of IPA (n=154). PCR results were compared to culture détection as gold standard and to clinical data. Results: BAL fluids from 10 patients of group A were PCR positive. One case was falsely negative. Among group B, one case was PCR positive, and the second one PCR negative but had negative BAL cultures (only culture positive sputum). No false positive was detected among group C. Comparing to culture, sensitivity was 91%, specificity, 100%, positive predictive value, 100% and négative predictive value, 99%. Conclusion: 1. Aspergillus fumigatus PCR in BAL fluid was an accurate test to diagnose culture negative patients with IPA and to confirm culture positive samples; however it doesn't make difference between infection and colonization. 2. It is an appropriate test to exclude Aspergillus infection in patients at risk of invasive illness. [less ▲]

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See detailAn investigation of the large-scale variability of the apparently single Wolf-Rayet star WR 1
Morel, Thierry ULiege; Georgiev, L. N.; Grosdidier, Y. et al

in Astronomy and Astrophysics (1999), 349

In recent years, much studies have focused on determining the origin of the large-scale line-profile and/or photometric patterns of variability displayed by some apparently single Wolf-Rayet stars, with ... [more ▼]

In recent years, much studies have focused on determining the origin of the large-scale line-profile and/or photometric patterns of variability displayed by some apparently single Wolf-Rayet stars, with the existence of an unseen (collapsed?) companion or of spatially extended wind structures as potential candidates. We present observations of <ASTROBJ>WR 1</ASTROBJ> which highlight the unusual character of the variations in this object. Our narrowband photometric observations reveal a gradual increase of the stellar continuum flux amounting to Delta v ~ 0.09 mag followed by a decline on about the same timescale (3-4 days). Only marginal evidence for variability is found during the 11 following nights. Strong, daily line-profile variations are also observed but they cannot be easily linked to the photometric variations. Similarly to the continuum flux variations, coherent time-dependent changes are observed in 1996 in the centroid, equivalent width, and skewness of He Ii lambda 4686. Despite the generally coherent nature of the variations, we do not find evidence in our data for the periods claimed in previous studies. While the issue of a cyclical pattern of variability in <ASTROBJ>WR 1</ASTROBJ> is still controversial, it is clear that this object might constitute in the future a cornerstone for our understanding of the mechanisms leading to the formation of largely anisotropic outflows in Wolf-Rayet stars. [less ▲]

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See detailAdsorption of polyampholyte copolymers at the solid/liquid interface: the influence of pH and salt on the adsorption behaviour
Mahltig, Boris; Walter, H.; Harrats, C. et al

in Physical Chemistry Chemical Physics [=PCCP] (1999), 1(17), 3853-3856

Polyampholytes are macromolecules that contain oppositely charged groups. We have studied the adsorption of the polyampholyte diblock copolymer poly(methacrylic acid)-block-poly((dimethylamino)ethyl ... [more ▼]

Polyampholytes are macromolecules that contain oppositely charged groups. We have studied the adsorption of the polyampholyte diblock copolymer poly(methacrylic acid)-block-poly((dimethylamino)ethyl methacrylate), PMAA-b-PDMAEMA, on oxidized silicon surfaces. The amount of polymer adsorbed from aqueous solution of different pH and salt concentration was measured by ellipsometry. The influence of the added salts NaCl, Na2SO4 and CaCl2 was determined. In every case adsorption took place, although the polyampholyte and the substrate exhibit the same sign of net charge. For all types of salt, the adsorbed amount shows two maxima close to the isoelectric point (IEP) of the polymer as a function of pH. Directly at the IEP of the polyampholyte, no adsorption was found. The measured dependences can be explained by the adsorption of one or the other of the two blocks depending on acidity and ionic strength. Furthermore, the lateral structure of the dried films was investigated by scanning force microscopy (SFM). [less ▲]

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