Publications ORBi OA
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See detailLe controle de la transcription genique en tant que nouvelle cible therapeutique dans le traitement de l'asthme
Desmet, Christophe ULg; Louis, Renaud ULg; Lekeux, Pierre ULg et al

in Revue Médicale de Liège (2005), 60(10), 789-795

The recent advances in the knowledge of the molecular mechanisms underlying asthma have lead to a significant improvement of the current treatments of the disease and opened new perspectives for the ... [more ▼]

The recent advances in the knowledge of the molecular mechanisms underlying asthma have lead to a significant improvement of the current treatments of the disease and opened new perspectives for the development of therapeutic alternatives to inhaled corticosteroids. The selective targeting of transcription factors controlling the expression of the genes implicated in the pathogenesis of asthma is one of these privileged strategies. This review aims at describing the most promising new therapeutic targets in the control of asthmatic inflammation at the gene transcription level. [less ▲]

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See detailLe pied diabetique
Van Damme, Hendrik ULg; Limet, Raymond ULg

in Revue Médicale de Liège (2005), 60(5-6, May-Jun), 516-25

The pathophysiological mechanisms underlying a diabetic foot disease are complex and multifactorial, including neuropathy, ischemia, infection and abnormal foot biomechanics. All these factors are often ... [more ▼]

The pathophysiological mechanisms underlying a diabetic foot disease are complex and multifactorial, including neuropathy, ischemia, infection and abnormal foot biomechanics. All these factors are often intricated and source of delayed wound healing. Insight in the pathophysiology of the diabetic foot provides a comprehensive basis for a protocol of primary and secondary preventive care. Since non-enzymatic glycosilation of proteins and of connective tissue underlies structural changes in vessels, nerves and osteo-articular structures, a rigid control of blood glucose levels is of paramount importance. Early recognition of the etiology of foot lesions and prompt management of foot ulcers are essential for successful outcome. Aggressive treatment of infections, clinical assessment and correction of vascular occlusive disease (diabetic macroangiopathy), adequate wound care and appropriate off-loading (pressure relief) of the ulcer are essential steps in the treatment protocol. It is not surprising that optimal management of the diabetic foot requires a multidisciplinary approach in a Diabetic Foot Clinic, coordinating care-provisions by a team of diabetologist, infectiologist, vascular surgeon, interventional radiologist, plastic surgeon, podiatrist and specialized nurse. Applying evidence-based multidisciplinary treatment results in a 50% reduction of major lower-limb amputation in this high risk group. [less ▲]

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See detailParentification-Infantilisation
Stassart, Martine ULg

in Thérapie Familiale (2005), 26(1), 36-53

The research on the double bind context helps us understand the individuation process of mothers who are described as parentified and whose child seems to present borderline or psychotic problems. In a ... [more ▼]

The research on the double bind context helps us understand the individuation process of mothers who are described as parentified and whose child seems to present borderline or psychotic problems. In a previous paper, we presented a study on double bind between those mothers and their child. The aim of this present paper is to develop the transgenerational aspects of those family patterns. The paper will describe the individuation process of the parentifed mother based on the position she had in her own family, the way she grew up and progressively developed. We will examine her functions towards each of her parents and as well as towards her sibling. We will focus on different elements such as contact style, pat¬terns of interaction in the creation of an « experiencing world » that is so crucial in double bind process. This paper is the last of four. They all tried to expand the area of double bind by clarifyinging the Bateson's metaphor about the double bind as the only visible part of an iceberg. Further than a logical conceptual organization for double bind patterns, the aim of this paper is to provide therapists with a methodological tool they could use as a map which is co-created with the family to progressively reveal the gond reasons for this pathological situation to be and question its pertinence in the family today. [less ▲]

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See detailEULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility
Conaghan, P.; D'Agostino, M. A.; Ravaud, P. et al

in Annals of the Rheumatic Diseases (2005), 64(12), 1710-1714

BACKGROUND: Synovial inflammation (as defined by hypertrophy and effusion) is common in osteoarthritis (OA) and may be important in both pain and structural progression. OBJECTIVE: To determine if ... [more ▼]

BACKGROUND: Synovial inflammation (as defined by hypertrophy and effusion) is common in osteoarthritis (OA) and may be important in both pain and structural progression. OBJECTIVE: To determine if decision rules can be devised from clinical findings and ultrasonography (US) to allow recognition of synovial inflammation in patients with painful knee OA. METHODS: A EULAR-ESCISIT cross sectional, multicentre study enrolled subjects with painful OA knee who had clinical, radiographic, and US evaluations. A classification and regression tree (CART) analysis was performed to find combinations of predictor variables that would provide high sensitivity and specificity for clinically detecting synovitis and effusion in individual subjects. A range of definitions for the two key US variables, synovitis and effusion (using different combinations of synovial thickness, depth, and appearance), were also included in exploratory analyses. RESULTS: 600 patients with knee OA were included in the analysis. For both knee synovitis and joint effusion, the sensitivity and specificity were poor, yielding unsatisfactory likelihood ratios (75% sensitivity, 45% specificity, and positive LR of 1.36 for knee synovitis; 71.6% sensitivity, 43.2% specificity, and positive LR of 1.26 for joint effusion). The exploratory analyses did not improve the sensitivity and specificity (demonstrating positive LRs of between 1.26 and 1.57). CONCLUSION: Although it is possible to determine clinical and radiological predictors of OA inflammation in populations, CART analysis could not be used to devise useful clinical decision rules for an individual subject. Thus sensitive imaging techniques such as US remain the most useful tool for demonstrating synovial inflammation of the knee at the individual level. [less ▲]

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See detailComment je préviens ... par des soins dermo-cosmetiques, l'expression d'une acné qui couve.
Pierard, Gérald ULg; Pierard, Claudine ULg

in Revue Médicale de Liège (2005), 60(9), 741-3

Acne is a disorder affecting the majority of subjects during adolescence that may persist at various grades of severity during adulthood. This disorder may manifest itself at different levels of severity ... [more ▼]

Acne is a disorder affecting the majority of subjects during adolescence that may persist at various grades of severity during adulthood. This disorder may manifest itself at different levels of severity ranging from discrete to severe. The lesions may be sporadic or follow a wild course. The therapeutic strategy depends on these progression characteristics and must fit to each individual patient. This review focuses on the minor but the most frequent types of acne that may benefit from dermocosmetic treatments. [less ▲]

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See detailLe formes "contingentes" en égyptien ancien : une catégorisation en question
Polis, Stéphane ULg

in Cannuyer, Christian (Ed.) La langue dans tous ses états (2005)

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See detailDAS28 best reflects the physician's clinical judgment of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score in patients under infliximab treatment
Cruyssen, B. V.; Van Looy, S.; Wyns, B. et al

in Arthritis Research & Therapy (2005), 7(5), 1063-1071

This study is based on an expanded access program in which 511 patients suffering from active refractory rheumatoid arthritis (RA) were treated with intravenous infusions of infliximab (3 mg/kg ... [more ▼]

This study is based on an expanded access program in which 511 patients suffering from active refractory rheumatoid arthritis (RA) were treated with intravenous infusions of infliximab (3 mg/kg+ methotrexate (MTX)) at weeks 0, 2, 6 and every 8 weeks thereafter. At week 22, 474 patients were still in follow-up, of whom 102 (21.5%), who were not optimally responding to treatment, received a dose increase from week 30 onward. We aimed to build a model to discriminate the decision to give a dose increase. This decision was based on the treating rheumatologist's clinical judgment and therefore can be considered as a clinical measure of insufficient response. Different single and composite measures at weeks 0, 6, 14 and 22, and their differences over time were taken into account for the model building. Ranking of the continuous variables based on areas under the curve of receiver-operating characteristic ( ROC) curve analysis, displayed the momentary DAS28 Disease Activity Score including a 28-joint count) as the most important discriminating variable. Subsequently, we proved that the response scores and the changes over time were less important than the momentary evaluations to discriminate the physician's decision. The final model we thus obtained was a model with only slightly better discriminative characteristics than the DAS28. Finally, we fitted a discriminant function using the single variables of the DAS28. This displayed similar scores and coefficients as the DAS28. In conclusion, we evaluated different variables and models to discriminate the treating rheumatologist's decision to increase the dose of infliximab (+MTX), which indicates an insufficient response to infliximab at 3 mg/kg in patients with RA. We proved that the momentary DAS28 score correlates best with this decision and demonstrated the robustness of the score and the coefficients of the DAS28 in a cohort of RA patients under infliximab therapy. [less ▲]

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See detailInterest of the use of electronic nose for field monitoring of odours in the environment
Nicolas, Jacques ULg

in Lehr Jay H.; Keeley Jack (Eds.) Water encyclopedia. Volume 2 : Water quality control. (2005)

Electronic nose is a promising technique for field monitoring of malodours in the environment. It is based on an array of non-specific gas sensors coupled with some form of mathematical data processing ... [more ▼]

Electronic nose is a promising technique for field monitoring of malodours in the environment. It is based on an array of non-specific gas sensors coupled with some form of mathematical data processing method to analyse the global response patterns. Some applications concerning the control of water quality are reported in the literature. They often impliy the generation of a headspace gas above liquid samples, but they also concern the odour emitted in the air from wastewater. The typical needs of the final user require both qualitative and quantitative approaches, i.e. both discriminating between slight variations in complex gas mixtures and monitoring a global odour signal which can be correlated with classical characterisation variables of water or air quality. Although potential applications in odour assessment by electronic noses are numerous, a number of challenges still need to be overcome: understanding and controlling the impact of environmental parameters (such as temperature and humidity), improving sensor sensitivity and noise reduction or developing calibration procedures to account for sensor drift. The present limitations of electronic nose technology restrict its use in the environment to the odour monitoring in the surroundings of the emission with instruments specifically designed for the application. [less ▲]

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See detailReprésentations de la figure de Charles Quint : des espoirs suscités aux traces dans une chronique française de la fin de sa vie. Comparaison de trois représentations : Molinet, Ladam, Le Blond
Dozo, Björn-Olav ULg

in Moyen français (Le). Revue d'études linguistiques et littéraires fondée par Giuseppe di Stefano (2005), 57-58

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See detailDevelopment of a contact model adapted to incremental forming
Henrard, Christophe ULg; Bouffioux, Chantal ULg; Godinas, A. et al

in Banabic, D. (Ed.) Proceedings of the 8th ESAFORM Conference on Material Forming (2005)

The objective of this article is to present the development of a new method for taking into account the contact between the tool and the blank during incremental forming. First, the need for such a model ... [more ▼]

The objective of this article is to present the development of a new method for taking into account the contact between the tool and the blank during incremental forming. First, the need for such a model is justified. Then, the basic features of the adapted dynamic explicit scheme are presented, followed by the new algorithms proposed and their programming. Finally, some conclusions and perspectives are drawn. [less ▲]

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See detailMéthodologie de l'enquête MISSION (Ménopause, risque de cancer du sein, morbidité et prévalence)
Chevalier, T.; Daures, J. P.; Micheletti, M. C. et al

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (2005), 34(7-C1), 658-665

Objective. The ambition of this article is to detail and to explain the methodology of the study named MISSION (Menopause: breast cancer risk, morbidity and prevalence). The aims of MISSION are to ... [more ▼]

Objective. The ambition of this article is to detail and to explain the methodology of the study named MISSION (Menopause: breast cancer risk, morbidity and prevalence). The aims of MISSION are to determine the prevalence of breast cancer and global morbidity in France among menopausal women treated or not with hormone replacement therapy (HRT) and followed by a gynecologist. Material and method. 6600 menopausal women [3300 with HRT — ie for estrogen: only estradiol via oral or transdermal administration; for progestogen: natural progesterone or assimiled or one pregnane derived (excluding medroxyprogesterone acetate) or non-pregnane derived — and 3300 without HRT] will be enrolled in France between January 5 2004 and February 28 2005 by 825 gynecologists, members or not of the National Federation of Medical Gynecologists (FNCGM). This study design is a historico-prospective with case randomization. MISSION is conducted by a Theramex-Merck Laboratories initiative in collaboration with a WHO (World Health Organization) Collaborating Center for Public Health Aspects of Rheumatic Diseases and a multidisciplinary expert group. Conclusion. First results of this study will contribute to better knowledge of women health. [less ▲]

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See detailLa maladie coronarienne diabetique.
legrand, D.; Legrand, Victor ULg

in Revue medicale de Liege (2005), 60(5-6), 526-30

Diabetes mellitus represents a major coronary risk factor. Diabetes promotes atherosclerotic plaque development through different mechanisms among which oxidative stress induced by hyperglycaemia appears ... [more ▼]

Diabetes mellitus represents a major coronary risk factor. Diabetes promotes atherosclerotic plaque development through different mechanisms among which oxidative stress induced by hyperglycaemia appears to play a major role. Knowledge of pathophysiologic mechanisms associated with diabetes helps to better understand the rationale for treatment. Besides a tight control of all cardiovascular risk factors, prescription of drugs aiming of stabilization or even reduction of atherosclerosis should be systematically recommended. These drugs include statines, ACE inhibitors and aspirin eventually combined with clopidogrel. The use of beta blockers should be encouraged in case of stable angina. Finally, any patient with symptomatic modification suggesting acute coronary syndrome should be considered for myocardial revascularization. [less ▲]

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See detailLe coenzyme Q10: biochimie, physiopathologie de sa carence et interet potentiel d'une augmentation de ses apports.
Malchair, P.; Van Overmeire, Lionel ULg; Boland, André ULg et al

in Revue Médicale de Liège (2005), 60(1), 45-51

After a brief reminding of the synthesis and function of coenzyme Q10, this article tries to summarise the current state of knowledge about the consequences of its deficiency and about the potential ... [more ▼]

After a brief reminding of the synthesis and function of coenzyme Q10, this article tries to summarise the current state of knowledge about the consequences of its deficiency and about the potential benefits of an increased intake of this coenzyme. We then describe the arguments in favour of such an increase in cardiac diseases and in Parkinson's disease. [less ▲]

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See detailRiver contract in Wallonia (Belgium) and its application for water management in the Sourou valley (Burkina Faso)
Rosillon, Françis ULg; Vander Borght, Paul ULg; Bado Sama, H.

in Water Science & Technology (2005), 52(9), 85-93

Inspired by the experience of a river contract in Wallonia (Belgium) since 1990, the implementation of a first river contract has been initiated in a West African country, Burkina Faso. This application ... [more ▼]

Inspired by the experience of a river contract in Wallonia (Belgium) since 1990, the implementation of a first river contract has been initiated in a West African country, Burkina Faso. This application is not limited to a simple transposition of the Walloon model. The Burkina context calls for adaptation to the local environmental and socio-economical realities with an adequate partnership management. The importance of the mobilization around this project of institutional partners, as well as local collectivities, agricultural producers and water users in general reveals the great expectations of the actors concerning this new tool of water participative management. But will the latter be equal to the task? A first assessment has been drawn up one year after the launch. During the first year of the project, a participative diagnostic was implemented but the understanding of basic notions of water management such as 'river' (not translatable in the local language), 'watershed', 'contract' were not obvious. After the identification of functions and uses of water in the basin, an environmental survey was started. This approach allows study with the river committees of the priority actions to be developed as a first project of restoration of the gallery forest alongside the stream to fight against desertification. This project of integrated and participative management of water at sub-basin level is a concrete example of solidarity and exchange know-how between North and South in the context of a sustainable development. [less ▲]

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See detail"D'un mur à l'autre", note sous l'avis de la Cour internationale de Justice du 9 juillet 2004 sur les conséquences juridiques de l'édification d'un mur dans le territoire palestinien occupé
Vincent, Philippe ULg

in Revue de la Faculté de Droit de l'Université de Liège (2005), 1

Analyse de l'avis rendu le 9 juillet 2004 sur la question de la légalité du mur de séparation construit par l'Etat d'Israêl.

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See detailWhole-system metabolism and CO2 fluxes in a Mediterranean Bay dominated by seagrass beds (Palma Bay, NW Mediterranean)
Gazeau, Frédéric; Duarte, C. M.; Gattuso, Jean-Pierre et al

in Biogeosciences (2005), 2(1), 43-60

Planktonic and benthic incubations (bare and Posidonia oceanica vegetated sediments) were performed at monthly intervals from March 2001 to October 2002 in a seagrass vegetated area of the Bay of Palma ... [more ▼]

Planktonic and benthic incubations (bare and Posidonia oceanica vegetated sediments) were performed at monthly intervals from March 2001 to October 2002 in a seagrass vegetated area of the Bay of Palma (Mallorca, Spain). Results showed a contrast between the planktonic compartment, which was on average near metabolic balance (-4.6 +/- 5.9 mmol O-2 m(-2) d(-1)) and the benthic compartment, which was autotrophic (17.6 +/- 8.5 mmol O-2 m(-2) d(-1)). During two cruises in March and June 2002, planktonic and benthic incubations were performed at several stations in the bay to estimate the whole-system metabolism and to examine its relationship with partial pressure of CO2 (pCO(2)) and apparent oxygen utilisation (AOU) spatial patterns. Moreover, during the second cruise, when the residence time of water was long enough, net ecosystem production (NEP) estimates based on incubations were compared, over the Posidonia oceanica meadow, to rates derived from dissolved inorganic carbon (DIC) and oxygen (O-2) mass balance budgets. These budgets provided NEP estimates in fair agreement with those derived from direct metabolic estimates based on incubated samples over the Posidonia oceanica meadow. Whereas the seagrass community was autotrophic, the excess organic carbon production therein could only balance the planktonic heterotrophy in shallow waters relative to the maximum depth of the bay ( 55 m). This generated a horizontal gradient from autotrophic or balanced communities in the shallow seagrass-covered areas, to strongly heterotrophic communities in deeper areas of the bay. It seems therefore that, on an annual scale in the whole bay, the organic matter production by the Posidonia oceanica may not be sufficient to fully compensate the heterotrophy of the planktonic compartment, which may require external organic carbon inputs, most likely from land. [less ▲]

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See detailInteractions Homme-Insectes : aperçu de 10 ans d'échantillonnage passif au Musée de Zoologie de Liège
Loneux, Michèle ULg

in Notes Fauniques de Gembloux (2005), 56

Le Musée et l'Institut de Zoologie de l'Université de Liège drainent des demandes en tout genre concernant les interactions et la cohabitation entre homme et animaux. Environ trois quarts des demandes ... [more ▼]

Le Musée et l'Institut de Zoologie de l'Université de Liège drainent des demandes en tout genre concernant les interactions et la cohabitation entre homme et animaux. Environ trois quarts des demandes annuelles aboutissant au Musée ont trait aux insectes. Elles émanent en majorité de particuliers, mais de plus en plus également de sociétés ou d'administrations. Notre formation de biologiste naturaliste, ayant bénéficié de l'orientation entomologique des enseignements de Ch. Jeuniaux, nous permet de rencontrer les besoins de la région et d'assurer un service d'identification et de renseignements entomologiques, en plus de la gestion des collections scientifiques du Musée de Zoologie. Du point de vue scientifique, cette forme d'échantillonnage nous a mis en présence, ces dernières années, de quelques cas intéressants. Du point de vue humain, l'impact de notre réponse est décisif sur l'attitude des gens face à l'animal rencontré, montrant par là le peu de culture entomologique du grand public et le rôle éducatif et apaisant de l'entomologiste. Du point de vue société, notre présence dans cette institution publique permet d'assumer un rôle d'expert et un rôle pédagogique, illustrés par quelques cas précis. En perspectives, cette belle aventure sera terminée en octobre 2003, l'Université ayant choisi de faire rentrer le patrimoine des collections scientifiques du Musée de zoologie dans l'Aquarium public, et de confier leur conservation au seul gestionnaire de l'Aquarium. L'avenir des collections dépend de l'intérêt que les scientifiques leur porte? [less ▲]

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See detailA PCR method for detection of bifidobacteria in raw milk and raw milk cheese: comparison with culture-based methods
Delcenserie, Véronique ULg; Bechoux, Nathalie ULg; China, Bernard et al

in Journal of Microbiological Methods (2005), 61(1), 55-67

Bifidobacteria are well known for their beneficial effects on health and are used as probiotics in food and pharmaceutical products. As they form one of the most important groups in both human and animal ... [more ▼]

Bifidobacteria are well known for their beneficial effects on health and are used as probiotics in food and pharmaceutical products. As they form one of the most important groups in both human and animal feces, their use as fecal indicator organisms in raw milk products has recently been proposed. Bifidobacteria species isolated in humans are different from those isolated in animals. It should therefore be possible to determine contamination origin (human or animal). A method of detecting the Bifidobacterium genus was developed by PCR targeting the hsp60 gene. The genus Bifidobacterium was identified by PCR amplification of a 217-bp hsp60 gene fragment. The degenerated primer pair specific to the Bifidobacterium genus used was tested for it specificity on 127 strains. Sensitivity was measured on artificially contaminated samples. Food can however be a difficult matrix for PCR testing since it contains PCR inhibitors. So an internal PCR control was used. An artificially created DNA fragment of 315 bp was constructed. The PCR detection method was tested on raw milk and cheese samples and compared with three culture-based methods, which comprised enrichment and isolation steps. The enrichment step used Brain Heart Infusion medium with propionic acid, iron citrate, yeast extract, supplemented with mupirocin (BHMup) or not (BH) and the isolation step used Columbia blood agar medium, supplemented with mupirocin (CMup) or not (C). The method using mupirocin at both enrichment and isolation steps and the PCR method performed from the culture in BHMup enrichment medium were shown to be the most efficient. No significant difference was observed in raw milk samples between PCR from BHMup and the culture-based method BHMup/CMup, while a significant difference was noticed between the same methods in raw milk cheese samples, which would favor using PCR. The results suggested that PCR on the hsp60 gene was convenient for a rapid detection of bifidobacteria in raw milk and raw milk cheese samples and that bifidobacteria always present throughout raw milk cheese production could be efficiently used as fecal indicators. [less ▲]

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