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See detailAetiology and physiopathology of preeclampsia and related forms.
Lorquet, Sophie ULg; Pequeux, Christel ULg; Munaut, Carine ULg et al

in Acta Clinica Belgica (2010), 65(4), 237-41

Preeclampsia, a pregnancy-specific syndrome characterized by hypertension, proteinuria and oedema, resolves on placental delivery. Its pathogenesis is thought to be associated to a hypoxic placenta ... [more ▼]

Preeclampsia, a pregnancy-specific syndrome characterized by hypertension, proteinuria and oedema, resolves on placental delivery. Its pathogenesis is thought to be associated to a hypoxic placenta. Placental hypoxia is responsible for the maternal vascular dysfunction via the increased placental release of anti-angiogenic factors such as soluble flt1 and endoglin. These soluble receptors bind VEGF, PLGF and TGFbeta1 and 3 in the maternal circulation, causing endothelial dysfunction in many maternal tissues. Despite these recent and important new molecular findings, it is important to consider that normal pregnancy is also characterized by systemic inflammation, oxidative stress and alterations in levels of angiogenic factors and vascular reactivity. Both the placenta and maternal vasculatures are major sources of reactive oxygen and nitrogen species which can produce powerful pro-oxidants that covalently modify proteins and alter vascular function in preeclampsia. Finally, the recent demonstration of activating auto-antibodies to the Angiotensin 1 receptor that experimentally play a major pathogenic role in preeclampsia further indicates the pleiotropism of aetiologies of this condition. [less ▲]

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See detailMechanical behavior of a ferritic stainless steel under simple and complex loading paths
Rossi, Barbara ULg; Jaspart, Jean-Pierre ULg

in International Conference on Structure and Architecture : ICSA2010, Guimaraes 21-23 July 2010 (2010)

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See detailMolecular requirements for ethanol differential allosteric modulation of glycine receptors based on selective Gbetagamma modulation.
Yevenes, Gonzalo E; Moraga-Cid, Gustavo; Avila, Ariel et al

in Journal of Biological Chemistry (2010), 285(39), 30203-13

It is now believed that the allosteric modulation produced by ethanol in glycine receptors (GlyRs) depends on alcohol binding to discrete sites within the protein structure. Thus, the differential ethanol ... [more ▼]

It is now believed that the allosteric modulation produced by ethanol in glycine receptors (GlyRs) depends on alcohol binding to discrete sites within the protein structure. Thus, the differential ethanol sensitivity of diverse GlyR isoforms and mutants was explained by the presence of specific residues in putative alcohol pockets. Here, we demonstrate that ethanol sensitivity in two ligand-gated ion receptor members, the GlyR adult alpha(1) and embryonic alpha(2) subunits, can be modified through selective mutations that rescued or impaired Gbetagamma modulation. Even though both isoforms were able to physically interact with Gbetagamma, only the alpha(1) GlyR was functionally modulated by Gbetagamma and pharmacological ethanol concentrations. Remarkably, the simultaneous switching of two transmembrane and a single extracellular residue in alpha(2) GlyRs was enough to generate GlyRs modulated by Gbetagamma and low ethanol concentrations. Interestingly, although we found that these TM residues were different to those in the alcohol binding site, the extracellular residue was recently implicated in conformational changes important to generate a pre-open-activated state that precedes ion channel gating. Thus, these results support the idea that the differential ethanol sensitivity of these two GlyR isoforms rests on conformational changes in transmembrane and extracellular residues within the ion channel structure rather than in differences in alcohol binding pockets. Our results describe the molecular basis for the differential ethanol sensitivity of two ligand-gated ion receptor members based on selective Gbetagamma modulation and provide a new mechanistic framework for allosteric modulations of abuse drugs. [less ▲]

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See detailImmanence et transcendance dans la lecture heideggérienne d'Anaximandre
Pieron, Julien ULg

in Klèsis (2010), 15

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See detailAnalyse expérimentale de l'influence des largeurs d'alvéoles sur la débitance des déversoirs en touches de piano
Machiels, Olivier ULg; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in Houille Blanche (2010), (2), 22-28

Within the framework of updating the release and storage capacities of existing reservoirs, the use of piano keys weirs (PKW) can be an interesting alternative either to increase the discharge of a free ... [more ▼]

Within the framework of updating the release and storage capacities of existing reservoirs, the use of piano keys weirs (PKW) can be an interesting alternative either to increase the discharge of a free weir without changing the weir layout or the reservoir level, or increase the reservoir level before discharge while keeping the weir layout and the level of safety. In order to help to the understanding of the behavior of this new type of weirs and to characterize their hydraulic potential, the results of an experimental study with for objectives to study the influence of the relative width of the inlets and outlets on the hydrodynamic characteristics of the structure are presented. A process oriented analytical formulation for the evaluation of the discharge coefficient of the PKW tested on scale models is proposed. It is in satisfactory agreement with the experimental results and leads to an objective evaluation of the optimal ratio of the alveoli widths. [less ▲]

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See detailHybrid modelling of dike-break induced flows
Roger, Sebastian; Dewals, Benjamin ULg; Erpicum, Sébastien ULg et al

in Dittrich, Andreas; Koll, Katinka; Aberle, Jochen (Eds.) et al River Flow 2010 (2010)

In a hybrid approach experimental model data are combined with results from 3D and 2D numerical modelling. The latter was conducted by two different models solving the depth-averaged shallow water ... [more ▼]

In a hybrid approach experimental model data are combined with results from 3D and 2D numerical modelling. The latter was conducted by two different models solving the depth-averaged shallow water equations. 3D computations are based on the REYNOLDS-averaged NAVIER-STOKES equations (RANS) using a volume of fluid approach to capture the free water surface. Measurements were performed on a scale model which was especially designed to reproduce the specific conditions of dike breaks. In various simulations it turned out that 2D shallow water models are able to reproduce steadystate flow patterns of dike-break induced flows and that there is a low sensitivity of the solution concerning turbulence modelling, bed and wall roughness. Nevertheless, final flow splits and breach discharges are systematically underestimated. This discrepancy seems to result from inherent modelling assumptions such as zero-vertical velocity and hydrostatic pressure distribution. Therefore, the complementary use of 3D RANS and 2D depth-averaged modelling frameworks for detailed predictions of dike-break induced flows is discussed in the present paper, based on BOUSSINESQ and pressure coefficients, which represent effects of non-uniform velocity profiles and non-hydrostatic pressure distribution over water depth, respectively. Values of these coefficients are inferred from 3D numerical results for the final steady state. [less ▲]

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See detailAnnual report 2010 of the IGCP-580 Project.
Da Silva, Anne-Christine ULg; Whalen, Michael; Hladil, Jindrich et al

Report (2010)

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See detailWhen do faces capture attention? Evidence from eye movements
Devue, Christel ULg; Belopolsky, Artem; Theeuwes, Jan

in Perception (2010), 39 Suppl.

A recent visual search study showed that the presence of an upright distractor face slows the search for a butterfly target while a butterfly distractor does not affect the search for a target face ... [more ▼]

A recent visual search study showed that the presence of an upright distractor face slows the search for a butterfly target while a butterfly distractor does not affect the search for a target face, suggesting that faces capture attention automatically (Langton et al, 2008 Cognition 107 330-342). To further test this hypothesis, we recorded eye movements during a cued target search task. When the search target alternated between a face and a butterfly (Experiment 1), faces were found faster and with less saccades than butterflies. The presence of the opposite distractor (eg a face during a search for a butterfly) slowed down the search but to a greater extent when the distractor was a face. Moreover, faces captured the eyes more frequently than butterflies. Inverted face targets were also found more efficiently than inverted butterfly targets and captured the eyes more than butterflies when presented as distractors (Experiment 2). However, when upright or inverted faces consistently appeared as irrelevant distractors during a butterfly or a flower target search (Experiment 3), they did not cause significant disruption. These results challenge the view that faces capture attention automatically and suggest that faces only attract attention when their processing is relevant during a search task. [less ▲]

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See detailLe grand âge en droit médical : entre ombres et lumière
Genicot, Gilles ULg

in Georges, Frédéric (Ed.) Le droit des seniors. Aspects civils, sociaux et fiscaux (2010)

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See detailComment j'explore une masse cervicale chez l'enfant
Costa de Araujo, Pedro ULg; Battisti, Oreste ULg

in Revue Médicale de Liège (2010), 65

The discovery of a cervical mass in a child suggests several possible diagnoses ranging from benign conditions to more severe pathologies, even cancer. Parents often worry and consult a physician when ... [more ▼]

The discovery of a cervical mass in a child suggests several possible diagnoses ranging from benign conditions to more severe pathologies, even cancer. Parents often worry and consult a physician when such a mass fails to regress after a few weeks. Palpation of small and solid lymph nodes is commonplace and generally trivial in children. A detailed clinical history and a careful examination often allow a distinction to be made between a benign and a serious condition. Additional tests are needed in case of doubt or in the prospect of reaching an precise aetiological diagnosis. These exams should be selected according to a decision algorithm. The investigation remains delicate. When the physician is convinced of the benign nature of the lymphadenopathy, there is no real need to identify the aetiology with the greatest precision, especially in acute cases with bilateral nodes that are commonly benign and spontaneously resolve. [less ▲]

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See detailCerebral folate deficiency and CNS inflammatory markers in Alpers disease.
Hasselmann, Oswald; Blau, Nenad; RAMAEKERS, Vincent ULg et al

in Molecular Genetics & Metabolism (2010), 99(1), 58-61

We describe a 3.5-year-old female with Alpers disease with a POLG genotype of p.A467T/p.G848S and with a lethal outcome. Laboratory investigation revealed elevated CSF neopterin, IL-6, IL-8, IFN-gamma ... [more ▼]

We describe a 3.5-year-old female with Alpers disease with a POLG genotype of p.A467T/p.G848S and with a lethal outcome. Laboratory investigation revealed elevated CSF neopterin, IL-6, IL-8, IFN-gamma, reduced CSF 5-methyltetrahydrofolate (5MTHF), and increased serum as well as CSF folate receptor blocking autoantibodies. Treatment with oral Leucovorine (5-formyl-tetrahydrofolate) was initiated at 0.25mg/kg bid, and later increased to 4mg/kg bid. Under treatment CSF levels of 5MTHF, seizure frequency and communicative abilities improved. Over a time span of 17months, CSF levels of IL-6 and IFN-gamma decreased, levels of folate receptor blocking autoantibodies continued to raise, whereas CSF IL-8 remained elevated 1500-fold above normal. The child died without apparent stress at the age of 5.5years. Alpers disease, a neurodegenerative disease usually presents in the first years of life as a progressive encephalopathy with multifocal myoclonic seizures, developmental regression, cortical blindness and early death. The underlying genetic defect has been attributed to mutations of the catalytic subunit of the mitochondrial DNA polymerase-gamma leading to an organ-specific mitochondrial DNA depletion syndrome with reduced activity of respiratory chain enzyme complexes in the brain and the liver. A curative therapy is not available. This case report of Alpers disease provides new insights into the pathophysiology of Alpers disease, where mitochondrial dysfunction in conjunction with inflammatory cytokines and blocking folate receptor autoantibodies may lead to a secondary cerebral folate deficiency syndrome. The treatment of the latter provides relief to the patient without stopping the underlying disease. [less ▲]

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See detailAlcoolisme et attribution d’intentions interpersonnelles sur base d’expressions faciales émotionnelles : Etude pilote
Dethier, Marie ULg; Volkova, Alessia; Neumann, Aurore et al

in Revue Francophone de Clinique Comportementale et Cognitive (2010), 15(3), 1-7

The ability to understand the emotional states of others is necessary in order to develop high quality interpersonal relationships. Alcohol-dependents (AD) display interpretative errors when decoding ... [more ▼]

The ability to understand the emotional states of others is necessary in order to develop high quality interpersonal relationships. Alcohol-dependents (AD) display interpretative errors when decoding emotional facial expressions (EFE). EFE communicate information not only regarding emotional states but also regarding interpersonal intentions. The purpose of the present study was to investigate whether, exposed to EFE, AD differ from healthy individuals in attributions of interpersonal intentions of dominance and affiliation. The purpose of dominance is to control the environment and the purpose of affiliation is to maintain the relationship with the object. In the present study, twenty AD and 20 healthy subjects attributed intentions of dominance and affiliation to 12 faces portraying joy, anger or sadness. Results revealed that AD differ from healthy individual in attribution of dominance but not of affiliation. AD make mistakes when decoding expressed emotions. The present study suggests that, compared to healthy subjects, they also tend to anticipate, in a biased way, interpersonal intentions. [less ▲]

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See detailHet vrije lichaam in beeld
Englebert, Jérôme ULg

in Nollet, Lieven (Ed.) Geen schuld, wel straf (2010)

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See detailMontrer des corps... libres
Englebert, Jérôme ULg

in Nollet, Lieven (Ed.) Condamné, pas coupable (2010)

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See detailReference values of central blood pressure and pulse wave velocity in relations with 24 hours ambulatory blood pressure monitoring in Belgian normotensive young subjects
Saint-Remy, Annie ULg; Krzesinski, Jean-Marie ULg

in Journal of Hypertension (2010), 28

The present study aimed to define reference values of central blood pressure (cBP) and Pulse Wave Velocity (PWV) together with 24H APPM in healththy normotensive young adults before starting a follow-up ... [more ▼]

The present study aimed to define reference values of central blood pressure (cBP) and Pulse Wave Velocity (PWV) together with 24H APPM in healththy normotensive young adults before starting a follow-up of their CV profile modifications over time. [less ▲]

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See detail1D numerical approach to model the flow over a piano key weir (PKW)
Erpicum, Sébastien ULg; Machiels, Olivier ULg; Archambeau, Pierre ULg et al

in Proc. Int. Conf. SimHydro 2010: Hydraulic modeling and uncertainty (2010)

Piano Key Weir (PKW) is a new type of weir showing appealing hydraulic capacities, in particular for low heads. However, its complex geometry, with a large set of parameters, makes difficult the ... [more ▼]

Piano Key Weir (PKW) is a new type of weir showing appealing hydraulic capacities, in particular for low heads. However, its complex geometry, with a large set of parameters, makes difficult the understanding of the flow features and consequently the definition of an optimal design. In this paper, we investigate how a 1D numerical approach can predict the flow over a PKW and thus help in identifying the most relevant geometric parameters. After a detailed description of the numerical model, a comparison of the numerical results with experimental data is realized, showing promising results. [less ▲]

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See detailLa circulation des personnes dans et vers l'Union européenne
Carlier, Jean-Yves ULg

in Journal de Droit Européen [=JDE] (2010)

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See detailImportance of pigtailed macaques (Macaca nemestrina leonina) in seed dispersal: impact on the ecological balance of the tropical rainforest at Khao Yai National Park, Thailand
Albert, Aurélie ULg; Huynen, Marie-Claude ULg; Savini, Tommaso ULg

Poster (2010)

Today, many countries of South-East Asia know about the alarming state of the forests existing on their territory and all agree that it is essential to save the remaining primary forest but also to enable ... [more ▼]

Today, many countries of South-East Asia know about the alarming state of the forests existing on their territory and all agree that it is essential to save the remaining primary forest but also to enable the regeneration of degraded areas, through natural or artificial reforestation. The conservation of tropical rainforests thus passes by the necessity to better understand the plant-animal interactions, and in particular, the seed dispersal process. While following a troop of pigtailed macaques (Macaca nemestrina leonina) accustomed to Man in Khao Yai National park (2 168 km ²), Thailand, we will bring important data relating to these seed dispersers potentially necessary but unfortunately vulnerable. Indeed, this vulnerable but little known species, seems to be essential to maintain forest diversity by dispersing many plant species, particularly those inaccessible to smaller frugivores. First results already show that they disperse many seed species, of all kind of size, in all forest types, from primary forest to secondary forest, thanks to various handling techniques. They also seem to show an adaptation in their daily travels according to resources availability. The next fieldworks will enable us to bring more precision in these results and their temporal variations and thus to conclude on the potential role of Macaca nemestrina in the tropical rainforest regeneration. [less ▲]

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