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See detailLe goût
Blecker, Christophe ULg

Speech/Talk (2007)

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See detailCompiling polymorphic miRNA-target interactions: the Patrocles database.
Hiard, Samuel ULg; Tordoir, Xavier ULg; Coppieters, Wouter ULg et al

Poster (2007, February 15)

Using positional cloning, we have recently identified the mutation responsible for muscular phenotype of the Texel sheep. It is located in the 3’UTR of the GDF8 gene - a known developmental repressor of ... [more ▼]

Using positional cloning, we have recently identified the mutation responsible for muscular phenotype of the Texel sheep. It is located in the 3’UTR of the GDF8 gene - a known developmental repressor of muscle growth - and creates an illegitimate target site for miRNA expressed in the same tissue. This causes miRNA-mediated translation inhibition of mutant GDF8 transcripts which leads to muscle hypertrophy. We followed up on this finding by searching for common polymorphisms and mutations that affect either (i) RNAi silencing machinery components, (ii) miRNA precursors or (iii) target sites. These might likewise alter miRNA-target interaction and could be responsible for substantial differences in gene expression level. They have been compiled in a public database (“Patrocles”: www.patrocles.org), where they are classified in (i) DNA sequence polymorphisms (DSP) affecting the silencing machinery, (ii) DSP affecting miRNA structure or expression and (iii) DSP affecting miRNA target sites. DSP from the last category were organized in four classes: destroying a target site conserved between mammals (DC), destroying a non-conserved target site (DNC), creating a non-conserved target site (CNC), or shifting a target site (S). To aid in the identification of the most relevant DSP (such as those were a target site is created in an antitarget gene), we have quantified the level of coexpression for all miRNA-gene pairs. Analysis of the numbers of Patrocles-DSP as well as their allelic frequency distribution indicates that a substantial proportion of them undergo purifying selection. The signature of selection was most pronounced for the DC class but was significant for the DNC and CNC class as well, suggesting that a significant proportion of non-conserved targets is truly functional. The Patrocles database allowed for the selection of DSP that are likely to affect gene function and possibly disease susceptibility. The effect of these DSP is being studied both in vitro and in vivo. In conclusion, Patrocles-DSP could be widespread and underlie an appreciable amount of phenotypic variation, including common disease susceptibility. [less ▲]

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See detailPREDetector : Prokaryotic Regulatory Element Detector
Hiard, Samuel ULg; Rigali, Sébastien ULg; Colson, Séverine ULg et al

Poster (2007, February 15)

Background: In the post-genomic area, in silico predictions of regulatory networks are considered as a powerful approach to decipher and understand biological pathways within prokaryotic cells. The ... [more ▼]

Background: In the post-genomic area, in silico predictions of regulatory networks are considered as a powerful approach to decipher and understand biological pathways within prokaryotic cells. The emergence of position weight matrices based programs has facilitated the access to this approach. However, a tool that automatically estimates the reliability of the predictions and would allow users to extend predictions in genomic regions generally regarded with no regulatory functions was still highly demanded. Result: Here, we introduce PREDetector, a tool developed for predicting regulons of DNA-binding proteins in prokaryotic genomes that (i) automatically predicts, scores and positions potential binding sites and their respective target genes, (ii) includes the downstream co-regulated genes, (iii) extends the predictions to coding sequences and terminator regions, (iv) saves private matrices and allows predictions in other genomes, and (v) provides an easy way to estimate the reliability of the predictions. Conclusion: We present, with PREDetector, an accurate prokaryotic regulon prediction tool that maximally answers biologists’ requests. PREDetector can be downloaded freely at http://www.montefiore.ulg.ac.be/~hiard/predetectorfr.html [less ▲]

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See detailLe financement de l'entreprise en début de vie
Van Caillie, Didier ULg; Leboutte, Denys

Learning material (2007)

This seminar discusses key elements allowing to determine which are the needs for cash in new ventures and how to master the financial structure of the new entity.

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See detailQuantifications naturelles projectivement équivariantes
Radoux, Fabian ULg

Scientific conference (2007, February 13)

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Peer Reviewed
See detailTowards an understanding of the Of ? p star HD 191612: phase-resolved multiwavelength observations
Nazé, Yaël ULg; Rauw, Grégor ULg; Pollock, A. M. T. et al

in Monthly Notices of the Royal Astronomical Society (2007), 375(1), 145-153

We present the analysis of phase-resolved X-ray and optical observations of the peculiar hot star HD 191612 (Of ? p). This star is known to display line-profile variations that are recurrent with a period ... [more ▼]

We present the analysis of phase-resolved X-ray and optical observations of the peculiar hot star HD 191612 (Of ? p). This star is known to display line-profile variations that are recurrent with a period of 538 d and its spectrum was found to present the signature of a magnetic field. In the X-rays, it is slightly overluminous compared to the canonical L-X/L-BOL) relation and appears brighter when the optical lines are strongest. Our XMM-Newton observations further reveal that the X-ray spectrum of HD 191612 exhibits rather broad lines and is dominated by a 'cool' (0.2-0.6 keV) thermal component, two characteristics at odds with the proposed magnetic rotator model. We also report for the first time the low-level variability of the metallic (absorption/emission) lines and He ii absorptions that appear to be associated with radial-velocity shifts. Finally, we compare our results with observations of the early-type stars and discuss several possible scenarios. [less ▲]

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See detailA cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy
Hilfiker-Kleiner, D.; Kaminski, K.; Podewski, E. et al

in Cell (2007), 128(3), 589-600

Postpartum cardiomyopathy (PPCM) is a disease of unknown etiology and exposes women to high risk of mortality after delivery. Here, we show that female mice with a cardiomyocyte-specific deletion of stat3 ... [more ▼]

Postpartum cardiomyopathy (PPCM) is a disease of unknown etiology and exposes women to high risk of mortality after delivery. Here, we show that female mice with a cardiomyocyte-specific deletion of stat3 develop PPCM. In these mice, cardiac cathepsin D (CD) expression and activity is enhanced and associated with the generation of a cleaved antiangiogenic and proapoptotic 16 kDa form of the nursing hormone prolactin. Treatment with bromocriptine, an inhibitior of prolactin secretion, prevents the development of PPCM, whereas forced myocardial generation of 16 kDa prolactin impairs the cardiac capillary network and function, thereby recapitulating the cardiac phenotype of PPCM. Myocardial STAT3 protein levels are reduced and serum levels of activated CD and 16 kDa prolactin are elevated in PPCM patients. Thus, a biologically active derivative of the pregnancy hormone prolactin mediates PPCM, implying that inhibition of prolactin release may represent a novel therapeutic strategy for PPCM. [less ▲]

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See detailLe français devrait-il servir de référence juridique?
Petit, Nicolas ULg

Diverse speeche and writing (2007)

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See detailWhen the book is wrong
Leclercq, Philippe ULg; Betz, Romain ULg; Lambermont, Bernard ULg et al

in Lancet (2007), 369

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See detailLa comète du siècle, McNaught C/2006 P1
Manfroid, Jean ULg; Jehin, Emmanuel ULg

Article for general public (2007)

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See detailLong term photometric monitoring with the Mercator telescope. Frequencies and mode identification of variable O-B stars
De Cat, P.; Briquet, Maryline ULg; Aerts, C. et al

in Astronomy and Astrophysics (2007), 463

Aims. We selected a large sample of O-B stars that were considered as (candidate) slowly pulsating B, beta Cep, and Maia stars after the analysis of their hipparcos data. We analysed our new seven ... [more ▼]

Aims. We selected a large sample of O-B stars that were considered as (candidate) slowly pulsating B, beta Cep, and Maia stars after the analysis of their hipparcos data. We analysed our new seven passband geneva data collected for these stars during the first three years of scientific operations of the mercator telescope. We performed a frequency analysis for 28 targets with more than 50 high-quality measurements to improve their variability classification. For the pulsating stars, we tried both to identify the modes and to search for rotationally split modes. Methods: We searched for frequencies in all the geneva passbands and colours by using two independent frequency analysis methods and we applied a 3.6 S/N-level criterion to locate the significant peaks in the periodograms. The modes were identified by applying the method of photometric amplitudes for which we calculated a large, homogeneous grid of equilibrium models to perform a pulsational stability analysis. When both the radius and the projected rotational velocity of an object are known, we determined a lower limit for the rotation frequency to estimate the expected frequency spacings in rotationally split pulsation modes. Results: We detected 61 frequencies, among which 33 are new. We classified 21 objects as pulsating variables (7 new confirmed pulsating stars, including 2 hybrid beta Cep/SPB stars), 6 as non-pulsating variables (binaries or spotted stars), and 1 as photometrically constant. All the Maia candidates were reclassified into other variability classes. We performed mode identification for the pulsating variables for the first time. The most probable l value is 0, 1, 2, and 4 for 1, 31, 9, and 5 modes, respectively, including only 4 unambiguous identifications. For 7 stars we cannot rule out that some of the observed frequencies belong to the same rotationally split mode. For 4 targets we may begin to resolve close frequency multiplets. Based on observations collected with the p7 photometer attached to the Flemish 1.2-m mercator telescope situated at the Roque de los Muchachos observatory on La Palma (Spain). Section [see full textsee full text], including Figs. is only available in electronic form at http://www.aanda.org, and Tables 2 and 3 are only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/463/243 [less ▲]

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See detailL'astronomie dans le monde
Manfroid, Jean ULg

Article for general public (2007)

Une nouvelle classe de lentilles gravitationnelles; Un trou noir dans un amas globulaire; Les lacs de Titan; Un trou noir géant absorbant une étoile; Anneau d'une naine blanche

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See detailPatient safety indicators
Jacques, Jessica ULg; Gillet, Pierre ULg

Report (2007)

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See detailLe prix fixe du livre en Belgique
Habrand, Tanguy ULg

Article for general public (2007)

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See detailCampagne de mesure des odeurs sur le CET de Malvoisin - Estimation des nuisances olfactives.
Nicolas, Jacques ULg; Denne, P.; Romain, Anne-Claude ULg et al

Report (2007)

The study is conducted in the frame of a programme of monitoring of all landfill sites in Wallonia. The "odour" part is assigned to ULg. The present report concerns more particularly a campaign on the ... [more ▼]

The study is conducted in the frame of a programme of monitoring of all landfill sites in Wallonia. The "odour" part is assigned to ULg. The present report concerns more particularly a campaign on the site of Malvoisin. Besides the usual field inspection technique, the research group has used GC-MS to estimate the chemical composition of the atmosphere over the tipping area, dynamic olfactometry and flux emission chamber to assess the odour flux generated by the waste material and a survey in the surrounding population. [less ▲]

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See detailTeaching versus research: A multi-tasking approach to multi-department universities
Gautier, Axel ULg; Wauthy, Xavier

in European Economic Review (2007), 51(2), 273-295

We study the possible implications of incentive schemes as a tool to promote efficiency in the management of universities. In this paper, we show that by designing internal financial rules which create ... [more ▼]

We study the possible implications of incentive schemes as a tool to promote efficiency in the management of universities. In this paper, we show that by designing internal financial rules which create yardstick competition for research funds, a multi-department university may induce better teaching quality and research, as compared to the performance of independent departments. [less ▲]

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