Publications ORBi OA
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See detailErrors in architectural design process : towards a cognitive model.
Safin, Stéphane ULg; Leclercq, Pierre ULg; Blavier, Adelaïde ULg

in Marjanovic, Dorian; Storga, Mario; Pavkovic, Neven (Eds.) et al Proceedings of the Design 2008 : 10th International Design Conference (2008)

In architectural design process, the human error has a particular status. The later it is detected, the more expensive it is. Moreover, some errors can not be detected given the current state of the ... [more ▼]

In architectural design process, the human error has a particular status. The later it is detected, the more expensive it is. Moreover, some errors can not be detected given the current state of the design process and object definition. In this paper, we propose a model based on cognitive theories about human errors, applied to architectural preliminary design. In this model we classify the consequences of a design decision (direct, indirect, detected and undetected), we describe the steps of decision in architecture in relation to the process of errors detection and we introduce the concept of evolutive context. [less ▲]

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See detailHow much is enough?
Coucke, Philippe ULg

in Onco : Revue Multidisciplinaire d'Oncologie (2008), 2(6), 221-222

Le traitement conservateur est une constante dans l’approche oncologique. Des efforts ont été développés afin de conserver au maximum l’intégrité de la fonction et/ou de l’image corporelle. Ce souci de ... [more ▼]

Le traitement conservateur est une constante dans l’approche oncologique. Des efforts ont été développés afin de conserver au maximum l’intégrité de la fonction et/ou de l’image corporelle. Ce souci de sauvegarde se traduit par des approches thérapeutiques non mutilantes: un exemple typique est le changement de paradigme thérapeutique au moment de l’introduction de la chirurgie conservatrice de la glande mammaire en lieu et place de la mastectomie. Ce concept de chirurgie non radicale a été possible grâce à l’association avec la radiothérapie externe postopératoire. Des essais randomisés ont permis de valider le concept et de démontrer que le risque de rechute loco-régionale et ultérieurement la survie ne sont pas modifiés comparés à une approche chirurgicale potentiellement délabrante. Ces essais randomisés ne se sont fort heureusement pas limités aux aspects purement oncologiques. De façon prospective on a pu déterminer l’excellence des résultats cosmétiques à moyen et à long terme. Il est vrai que cette approche par essais randomisés était un passage indispensable et a permis de valider ce concept thérapeutique. Il aurait été pour le moins étonnant de prôner d’emblée une approche chirurgicale non mutilante mais oncologiquement complète, si à terme le résultat esthétique aurait été inférieur à celui que l’on aurait pu escompter après mastectomie radicale suivie de reconstruction. [less ▲]

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See detailProgrammes d’inventaire et de surveillance des invertébrés en Wallonie (objectifs, structure et résultats)
Dufrêne, Marc ULg; Barbier, Yvan; Fichefet, Violaine

Conference (2008)

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See detailIn-orbit vibration testing of spacecraft structures
Poncelet, Fabien ULg; Kerschen, Gaëtan ULg; Golinval, Jean-Claude ULg

in International Conference on Noise and Vibration Engineering, Leuven, 2008 (2008)

In-orbit modal testing can be an interesting tool for the monitoring of spacecraft structures. In these applications, it is impossible to measure or to control the excitation resulting, for instance, from ... [more ▼]

In-orbit modal testing can be an interesting tool for the monitoring of spacecraft structures. In these applications, it is impossible to measure or to control the excitation resulting, for instance, from an impact with a small asteroid or from the working engines. Consequently the only realistic methodology must be an outputonly modal analysis, also called Operational Modal Analysis (OMA). This paper proposes another way of doing OMA where the post-processing (i.e. the physical modal parameter extraction) is simplified and automated. The methodology uses the Blind Source Separation (BSS) techniques which attempt to recover the source signals only from their observed mixtures. In case of structural dynamic responses, the source signals and the mixing matrix are equivalent to the modal coordinates and the mode matrix, respectively. The paper describes the complete methodology including the post-processing, and its feasibility is demonstrated using a numerical application modeling a truss satellite with the FE method. [less ▲]

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See detailNonlinear Normal Modes, Part II: Practical Computation using Numerical Continuation Techniques
Peeters, Maxime ULg; Viguié, Régis ULg; Sérandour, Guillaume et al

in 26th International Modal Analysis Conference, Orlando, 2008 (2008)

The concept of nonlinear normal modes (NNMs) is discussed in the present paper and its companion, Part I. One reason of the still limited use of NNMs in structural dynamics is that their computation is ... [more ▼]

The concept of nonlinear normal modes (NNMs) is discussed in the present paper and its companion, Part I. One reason of the still limited use of NNMs in structural dynamics is that their computation is often regarded as impractical. However, when resorting to numerical algorithms, we show that the NNM computation is possible with limited implementation effort, which paves the way to a practical method for determining the NNMs of nonlinear mechanical systems. The proposed algorithm relies on two main techniques, namely a shooting procedure and a method for the continuation of NNM motions. The algorithm is demonstrated using two different mechanical systems, a nonlinear two-degree-of-freedom system and a nonlinear cantilever beam discretized by the finite element method. [less ▲]

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See detailMagnetic flux patterns in superconductors deposited on a lattice of magnetic dots: A magneto-optical imaging study
Gheorghe, Diana G; Wijngaarden, Rinke J; Gillijns, Werner et al

in Physical Review. B : Condensed Matter (2008), 77(5),

We investigate the flux penetration in Pb films, of different shapes, deposited on top of a periodic array of Co/Pt dots with perpendicular anisotropy by means of magnetization and magneto-optical ... [more ▼]

We investigate the flux penetration in Pb films, of different shapes, deposited on top of a periodic array of Co/Pt dots with perpendicular anisotropy by means of magnetization and magneto-optical measurements. A clear dependence of the critical current density on the magnetic state of the dots and their polarity with respect to the direction of the applied magnetic field is observed by both techniques. The magnetic state of the dots changes the flux penetration from smooth to channelling. Additionally, in the fully magnetized state, an anisotropic current distribution is observed in circular-shaped samples. The flux penetration is dominated by avalanches only for configurations which correspond to a high critical current, irrespective of its origin, be it low temperature, magnetization state of the dots, or angle between the lattice of dots and the edge of the sample. [less ▲]

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See detailIntroduction à Latex.
Charles, Catherine ULg; Lecharlier, Loïc ULg; Renaud, Frédéric

in Notes de Statistique et d'Informatique (2008)

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See detailHigh Accumulation of Perfluorooctane Sulfonate (PFOS) in Marine Tucuxi Dolphins (Sotalia guianensis) from the Brazilian Coast
Dorneles, Paulo R; Lailson-Brito, José; Azevedo, Alexander et al

in Environmental Science & Technology (2008), 42(14), 5368-5373

Perfluorooctane sulfonate (PFOS) and other perfluoroalkyl compounds (PFCs) were measured in liver samples from 29 marine tucuxi dolphins from Rio de Janeiro state (RJ), Brazil. PFC measurement combined ... [more ▼]

Perfluorooctane sulfonate (PFOS) and other perfluoroalkyl compounds (PFCs) were measured in liver samples from 29 marine tucuxi dolphins from Rio de Janeiro state (RJ), Brazil. PFC measurement combined liquid chromatography and mass spectrometry, using a CapLC system connected to a Quadrupole- LIT mass spectrometer. PFOS was the only PFC detected and it was so in all samples. PFOS concentrations (ng ·g-1 dw) of dolphins (n)23) from the highly contaminated Guanabara Bay (in RJ) varied between 43 and 2431 as well as between 76 and 427 from areas of RJ other than the quoted bay (n ) 6). Concentrations of three fetuses and one neonate varied between 664 and 1590. Fetus/mother ratios were calculated in two situations (2.75 and 2.62). It seems that mother-to-calf transference plays important role for relationships between PFOS and age. When a one-year-old male calf presenting 2431 ng ·g-1 dw was excluded from the test, significant correlations were observed between PFOS concentrations and both age and total length. Despite the placental transference, PFOS concentrations were not significantly lower in females than in males. PFOS levels in marine tucuxi dolphins from Guanabara Bay are among the highest detected to date in cetaceans, andthismayrepresentathreat to the small population concerned. [less ▲]

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See detaileCole - Projet d'apprentissage et de remédiation en ligne
Jérôme, Françoise ULg; Vreeswijk, Valérie ULg; Georges, François ULg et al

Report (2008)

Recherche-développement consacrée à la conception d'un dispositif en ligne susceptible de soutenir l'autonomisation des apprenants dans le déploiement des compétences "lire" et "écrire" en français.

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See detailRefining Topological Relations between Regions Considering Their Shapes
Billen, Roland ULg; Kurata, Yohei

in Lecture Notes in Computer Science (2008), 5266/2008

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See detailIntroduire les dérivées par les vitesses. Pour qui ? Pourquoi ? Comment ?
Gantois; Schneider, Marguerite ULg

in Petit X (2008), 79

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See detailIntroduction à Octave
Charles, Catherine ULg

in Notes de Statistique et d'Informatique (2008)

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See detailImplicit/explicit memory dissociation in Alzheimer's disease: the consequence of inappropriate processing?
Willems, Sylvie ULg; Salmon, Eric ULg; Van der Linden, Martial ULg

in Neuropsychology (2008), 22(6), 710-7

Dual-process theories of recognition posit that perceptual fluency contributes to both familiarity-based explicit recognition and perceptual priming. However, the priming-without-recognition dissociation ... [more ▼]

Dual-process theories of recognition posit that perceptual fluency contributes to both familiarity-based explicit recognition and perceptual priming. However, the priming-without-recognition dissociation, as observed through the intact mere exposure effect and impaired recognition in patients with Alzheimer's disease (AD), might indicate that familiarity and perceptual priming are functionally distinct. This study investigated whether the AD patients' processing strategies at testing may explain this priming-without-recognition dissociation. First, we replicated the priming-without-recognition effect in 16 patients who exhibited intact exposure effects despite null recognition. Second, we showed that, under identical conditions, inducing a holistic processing strategy during recognition testing increased AD patients' recognition--performance was similar for AD patients and healthy control participants. Furthermore, prompting analytic processing during both priming and recognition tasks decreased AD patients' performance in both tasks. These findings suggest that the extent to which AD patients use perceptual fluency in priming and recognition tasks is contingent on their processing approach. The choice of processing strategy may depend on how difficult patients perceive the task to be. [less ▲]

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See detailChronic kidney disease in Taiwan.
Delanaye, Pierre ULg; Cavalier, Etienne ULg; Krzesinski, Jean-Marie ULg

in Lancet (2008), 372(9654), 19501950-1

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See detailSpinocerebellar ataxia type 2 (SCA2): clinical features and genetic analysis.
Mutesa, Leon; Pierquin, Geneviève ULg; Segers, Karin ULg et al

in Journal of Tropical Pediatrics (2008), 54(5), 350-2

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disease that results from the expansion of an unstable trinucleotide CAG repeat encoding for a polyglutamine tract. In ... [more ▼]

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disease that results from the expansion of an unstable trinucleotide CAG repeat encoding for a polyglutamine tract. In normal individuals, alleles contain between 14 and 31 CAG repeats, whereas the pathological alleles have more than 35 CAG repeats. The clinical phenotype of SCA2 includes a progressive cerebellar ataxia with additional features such as ophthalmoplegia, extra-pyramidal or pyramidal signs and peripheral neuropathy. We report a SCA2 large African family with several affected individuals. A major pathological allele carrying 43 CAG repeats was identified in the proband. To our knowledge, this is a first report of a SCA disorder described in Central African patients, thus indicating the need to consider this diagnosis in young African ataxic patients. [less ▲]

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See detailComment j'explore... un lymphome T cutane. Nouveaux horizons.
Quatresooz, Pascale ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2008), 63(4), 208-12

Although cutaneous T cell lymphomas remain rare, their incidence seems progressively on the rise. The main diagnostic criteria are issued from the clinico-pathological confrontation. Other methods help ... [more ▼]

Although cutaneous T cell lymphomas remain rare, their incidence seems progressively on the rise. The main diagnostic criteria are issued from the clinico-pathological confrontation. Other methods help support the diagnosis and establish a prognosis. [less ▲]

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See detailLe cas clinique du mois. Pemphigoide bulleuse apres brulure thermique.
Blaise, G.; Pierard, Claudine ULg; Quatresooz, Pascale ULg et al

in Revue Médicale de Liège (2008), 63(4), 182-3

In rare instances, some injuring physical factors such as thermal burns can be at the origin of bullous pemphigoid lesions. The early lesions are most often restricted to the injured skin area. Secondary ... [more ▼]

In rare instances, some injuring physical factors such as thermal burns can be at the origin of bullous pemphigoid lesions. The early lesions are most often restricted to the injured skin area. Secondary generalization is the natural evolution to be expected. However, once the episode is resolved, recurrence is exceptional. When the natural history of bullous pemphigoid differs from the regular type, the peculiar condition of development of these lesions does not change any of the diagnostic clinical and histological criteria, as well as the therapeutic procedures to follow. [less ▲]

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See detailMutational analysis of the zinc- and substrate-binding sites in the CphA metallo-beta-lactamase from Aeromonas hydrophila.
Bebrone, Carine ULg; Anne, Christine; Kerff, Frédéric ULg et al

in Biochemical Journal (2008), 414(1), 151-9

The subclass B2 CphA (Carbapenemase hydrolysing Aeromonas) beta-lactamase from Aeromonas hydrophila is a Zn(2+)-containing enzyme that specifically hydrolyses carbapenems. In an effort to evaluate ... [more ▼]

The subclass B2 CphA (Carbapenemase hydrolysing Aeromonas) beta-lactamase from Aeromonas hydrophila is a Zn(2+)-containing enzyme that specifically hydrolyses carbapenems. In an effort to evaluate residues potentially involved in metal binding and/or catalysis (His(118), Asp(120), His(196) and His(263)) and in substrate specificity (Val(67), Thr(157), Lys(224) and Lys(226)), site-directed mutants of CphA were generated and characterized. Our results confirm that the first zinc ion is in interaction with Asp(120) and His(263), and thus is located in the 'cysteine' zinc-binding site. His(118) and His(196) residues seem to be interacting with the second zinc ion, as their replacement by alanine residues has a negative effect on the affinity for this second metal ion. Val(67) plays a significant role in the binding of biapenem and benzylpenicillin. The properties of a mutant with a five residue (LFKHV) insertion just after Val(67) also reveals the importance of this region for substrate binding. This latter mutant has a higher affinity for the second zinc ion than wild-type CphA. The T157A mutant exhibits a significantly modified activity spectrum. Analysis of the K224Q and N116H/N220G/K224Q mutants suggests a significant role for Lys(224) in the binding of substrate. Lys(226) is not essential for the binding and hydrolysis of substrates. Thus the present paper helps to elucidate the position of the second zinc ion, which was controversial, and to identify residues important for substrate binding. [less ▲]

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See detailLe medicament du mois. Exenatide (Byetta). Incretinomimetique indique dans le traitement du diabete de type 2 apres echec et en complement des antidiabetiques oraux.
Scheen, André ULg; Van Gaal, L. F.

in Revue Médicale de Liège (2008), 63(3), 158-65

Exenatide (Byetta) is a synthetic derivative of exendin-4 and an agonist of receptors of glucagon-like peptide-1 (GLP-1). It is resistant to the rapid inactivation by dipeptidylpeptidase-4 and acts as an ... [more ▼]

Exenatide (Byetta) is a synthetic derivative of exendin-4 and an agonist of receptors of glucagon-like peptide-1 (GLP-1). It is resistant to the rapid inactivation by dipeptidylpeptidase-4 and acts as an incretin mimetic. It stimulates insulin secretion by the B cell in a glucose-dependent manner whereas it inhibits glucagon secretion. Exenatide improves mainly postprandial glucose concentrations and lowers glycated haemoglobin (HbA(1c)) levels, without being directly responsible for hypoglycaemia or requiring mandatory home blood glucose monitoring. Furthermore, it slows down gastric emptying and promotes sustained body weight reduction, even in absence of frequently reported nausea following treatment initiation. Exenatide is recommended and reimbursed in Belgium for the treatment of type 2 diabetes, in combination with metformin and a sulfonylurea, in patients not adequately controlled with maximal tolerated doses of these oral glucose-lowering agents. Exenatide is presented as pre-filled pens for subcutaneous injection. The recommended initial dose is 5 microg before morning and evening meals, to be up titrated to 10 microg twice daily. Exenatide may represent a valuable alternative to insulin therapy, especially in overweight or obese patients with type 2 diabetes and not ready to perform home blood glucose monitoring. [less ▲]

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