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See detailRadiofrequency ablation of liver tumors: short term evaluation
Detry, Olivier ULg; Detroz, Bernard ULg; Preud'Homme, Laurence ULg et al

in Acta Gastro-Enterologica Belgica (2001, January), 64(1), 11

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See detail120 laparoscopic sigmoidectomies in diverticulitis: a 9 years experience
Detroz, Bernard ULg; Moscato; Detry, Olivier ULg et al

in Acta Gastro-Enterologica Belgica (2001, January), 64(1), 49

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See detailLiver transplantation in Jehovah's witnesses
Detry, Olivier ULg; Honoré, Pierre ULg; De Roover, Arnaud ULg et al

in Acta Gastro-Enterologica Belgica (2001, January), 64(1), 53

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See detailStricturoplasty in Crohn disease: short and long term follow up
Laurent, Stanislas; Detry, Olivier ULg; Detroz, Bernard ULg et al

in Acta Gastro-Enterologica Belgica (2001, January), 64(1), 73

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See detailIntraperitoneal hyperthermic chemotherapy (IPHC) for treatment of peritoneal carcinomatosis
Detroz, Bernard ULg; Marchettini, P.; Joris, Jean ULg et al

in Acta Gastro-Enterologica Belgica (2001, January), 64(1), 80

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See detailTherapeutic Drug Monitoring of Azathioprine and 6-Mercaptopurine Metabolites in Crohn Disease
Belaiche, Jacques ULg; Desager, J. P.; Horsmans, Y. et al

in Scandinavian Journal of Gastroenterology (2001), 36(1), 71-6

BACKGROUND: 6-Mercaptopurine (6-MP) and its prodrug azathioprine (AZA) have proven efficacy in the treatment of Crohn disease (CD). The immunosuppressive properties of AZA/6-MP are mediated by the ... [more ▼]

BACKGROUND: 6-Mercaptopurine (6-MP) and its prodrug azathioprine (AZA) have proven efficacy in the treatment of Crohn disease (CD). The immunosuppressive properties of AZA/6-MP are mediated by the intracellular metabolism of 6-MP into its active metabolites, 6-thioguanine nucleotides (6TGN) and 6methylmercaptopurine (6-MMP). Preliminary studies have suggested that the red blood cell concentration of 6TGN (RBC 6TGN) is a potential guide to therapy. The aims of the study were to evaluate the RBC 6TGN concentrations in adult patients with CD under long-term AZA/6-MP therapy and to correlate it with response to treatment and haematological parameters. METHODS: Twenty-eight CD patients treated for at least 3 months with AZA/6-MP were prospectively studied. Patients were separated into three main groups: group 1 (n = 19), corresponding to quiescent CD receiving AZA (dose: 2.05 +/- 0.4 mg/kg/day for a mean of 28.6 +/- 25 months) or 6-MP (dose: 1.4 +/- 01 mg/kg/day for a mean of 7.5 +/- 3.5 months) alone; group 2 (n = 6), corresponding to quiescent CD treated by AZA (dose: 2.14 +/- 0.5 mg/kg/day for a mean of 29.5 +/- 22 months) with oral steroids; and group 3 (n = 3), corresponding to active CD on AZA (dose: 1.94 +/- 0.6 mg/kg/day for a mean of 31.3 +/- 35 months) as the only treatment. An assessment was also made by merging groups 1 and 2 forming a larger group of patients (n = 25) defined by clinical remission and groups 2 and 3 forming a larger group of patients (n = 9), non-complete responders with AZA/6-MP alone. Crohn disease index activity (CDAI), blood samples for full blood count and differential white cell count and measurement of RBC 6TGN and 6-MMP concentrations were evaluated at inclusion and at 6 months (n = 17). RBC 6TGN were measured using high performance liquid chromatography (HPLC) on heparinized blood. RESULTS: The baseline characteristics of the three groups of patients were similar. There was no significant difference among the three groups of patients regarding the dose and the duration of immunosuppressive treatment. There was no significant difference between groups according to various parameters tested. Particularly, the median RBC 6TGN concentration at inclusion was similar in the three groups of patients (166 (105-688), 183 (90-261) and 160 (52-194) pmol/8 x 10(8) RBC, respectively). The majority of patients had no detectable level of 6-MMP metabolite, except for 3 patients. There was also no difference between merging groups. Furthermore, there was no significant correlation between RBC 6TGN concentrations and the various biological parameters tested except for the mean erythrocyte volume. At 6 months, all patients of group 1 remained in remission and median RBC 6TGN concentration remained stable. No side effects were observed. CONCLUSIONS: There is, contrary to preliminary studies, a broad overlap in RBC 6TGN levels as well as for haematological parameters in patients in remission or not and responders or not to AZA/6-MP therapy. This suggests, beside a variability in the metabolism of these drugs, the existence of complex mechanisms of action. Nevertheless, beside the use of RBC 6TGN determination to confirm compliance to therapy, this dosage could be useful in non-responding patients, allowing, in absence of leukopenia, to increase the dose of AZA/6-MP safely. [less ▲]

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See detailA Fictional and Cultural Labyrinth: Caryl Phillips's The Nature of Blood
Ledent, Bénédicte ULg

in Ariel : A Review of International English Literature (2001), 32(1), 185-195

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See detailNon-Gaussian electrical fluctuations in a quasi-2d packing of metallic beads
Vandewalle, Nicolas ULg; Lenaerts, Cedric ULg; Dorbolo, Stéphane ULg

in Europhysics Letters [=EPL] (2001), 53(2), 197-201

The electrical properties of a two-dimensional packing of metallic beads are studied. Small mechanical perturbations of the packing lead to giant voltage fluctuations. Fluctuations are found to be non ... [more ▼]

The electrical properties of a two-dimensional packing of metallic beads are studied. Small mechanical perturbations of the packing lead to giant voltage fluctuations. Fluctuations are found to be non-Gaussian and seem to belong to Levy stable distributions. Anticorrelations have been also found for the sign of these fluctuations. [less ▲]

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See detailOpettajankoulutus Belgiassa
Renaville, François ULg

in Tempus (2001), (1), 18-19

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See detailTritons et salamandres du bord de l'eau
Denoël, Mathieu ULg

Article for general public (2001)

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See detailExercice d'analyse d'un décompte de crédit hypothécaire
Biquet, Christine ULg

in Bernauw, K.; Colle, P.; Dambre, M. (Eds.) et al Liber Amicorum Yvette Merchiers (2001)

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See detailACTH silent adenoma shrinking under cabergoline.
Petrossians, Patrick ULg; Ronci, N.; Valdes Socin, Hernan Gonzalo ULg et al

in European Journal of Endocrinology (2001), 144(1), 51-57

OBJECTIVES: The authors present a case report that proposes the use of cabergoline treatment in silent ACTH adenoma, an unusual member of the heterogeneous group of the so-called clinically non ... [more ▼]

OBJECTIVES: The authors present a case report that proposes the use of cabergoline treatment in silent ACTH adenoma, an unusual member of the heterogeneous group of the so-called clinically non-functioning pituitary adenomas. DESIGN: Following the clinical and radiological improvement of a recurrent silent ACTH adenoma in a 77-year-old patient treated with cabergoline (0.5 mg every 2 days for 2 years), in vitro studies of the original tumor were performed. METHODS: The original tumor from the patient was studied by in situ hybridization and dopamine D2 receptor autoradiography. It was compared with four macroprolactinomas and two macroadenomas from patients with Cushing's disease. RESULTS: The D2 receptor mRNA signal of the reported case was intense and of the same order of magnitude as that observed in control prolactinomas. Dopamine D2 receptor autoradiography was twice that of control corticotroph adenomas and was close to that observed in prolactinomas. CONCLUSIONS: This is the first description of an in vivo shrinkage of an ACTH silent adenoma under cabergoline. We demonstrate in vitro, the presence of D2 receptors in the primitive tumor in concentrations similar to those found in control prolactinomas. These results suggest that therapeutic trials with cabergoline might be undertaken in recurring cases of ACTH silent tumors and more generally, non-functioning pituitary adenomas. [less ▲]

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See detailLa régulation morphologique dans le cadre du projet urbain. Spécification d’instruments informatiques destinés à supporter les modes de régulation performantiels
Teller, Jacques ULg

Doctoral thesis (2001)

L'objet de cette thèse est d'améliorer l'efficacité de la prise de décision en matière de morphologie urbaine ; cette prise de décision étant considérée comme un processus impliquant la collaboration d'un ... [more ▼]

L'objet de cette thèse est d'améliorer l'efficacité de la prise de décision en matière de morphologie urbaine ; cette prise de décision étant considérée comme un processus impliquant la collaboration d'un grand nombre d'intervenants, aux intérêts assez souvent divergents. Ceci implique d'améliorer la prédictibilité aussi bien que la légitimité des décisions prises, tout en ménageant une certaine flexibilité et une marge d'adaptabilité au contexte bâti. Partant de cet objectif général, notre démarche scientifique vise à développer une instrumentation originale destinée aux autorités publiques qui ont la charge de la régulation morphologique, à savoir les municipalités bien sûr, mais également les autorités régionales ou nationales. Le rôle de cette instrumentation est de rendre plus explicites les intentions en matière de projet urbain vis-à-vis des différents acteurs impliqués dans le processus de décision. [less ▲]

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See detailTOWNSCOPE II - A computer system to support solar access decision-making
Teller, Jacques ULg; Azar, Sleiman ULg

in International Journal of Solar Energy (2001), 70/3

TOWNSCOPE II is a computer system devoted to support solar access decision-making in a sustainable urban design perspective. The software consists of a three-dimensional urban information system coupled ... [more ▼]

TOWNSCOPE II is a computer system devoted to support solar access decision-making in a sustainable urban design perspective. The software consists of a three-dimensional urban information system coupled with solar evaluation tools. We’ve paid particular attention to the fact that numerical results interpretation proves to be all but trivial in complex built environments. It is nevertheless a crucial aspect in decision-making, especially for current negotiated urban design practices. Which is why developing visual instruments in order to unveil the geometrical mechanisms lying behind the final results. Various spherical projections were thereby developed, each of them presenting specific advantages and disadvantages for solar access visualisation and/or evaluation purposes. [less ▲]

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See detailAre cardiac markers useful in patients with chronic renal failure?
Chapelle, Jean-Paul ULg

in Clinical Chemistry & Laboratory Medicine (2001), 39(suppl), 36

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See detailClinical applications of cardiac troponins
Chapelle, Jean-Paul ULg

in Acta Clinica Belgica (2001), 56

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See detailRelationship between procalcitonin plasma level and severity of infection
Servais, P.; Nys, Monique ULg; Canivet, Jean-Luc ULg et al

in Intensive Care Medicine (2001), 27(suppl.), 560

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See detailEngineering and manufacturing for biotechnology
Hofman, M.; Thonart, Philippe ULg

Book published by Kluwer academic publishers (2001)

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See detailAssociation between lipoprotein (A) and cardiac troponins in PTCA patients
Lutteri, Laurence ULg; Legrand, Victor ULg; Gielen, Jacques et al

in Clinical Chemistry & Laboratory Medicine (2001), 39(suppl), 278

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