Publications ORBi OA
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See detailIntroduction
Charlier, Sébastien ULg

in Art&Fact (2010), 29

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See detailRetinal Sensibility
Eloy, Céline ULg

in Art Même : Chronique des Arts Plastiques de la Communauté française de Belgique (2010)

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See detailRic-8: un nuevo GEF con estructura tipo "armadillo"
Figueroa, Maximiliano ULg

Doctoral thesis (2010)

RIC-8 is a highly conserved cytosolic protein (63 KDa) initially identified in C. elegans as an essential factor in neurotransmitter release and asymmetric cell division. Two different isoforms have been ... [more ▼]

RIC-8 is a highly conserved cytosolic protein (63 KDa) initially identified in C. elegans as an essential factor in neurotransmitter release and asymmetric cell division. Two different isoforms have been described in mammals, RIC-8A and RIC-8B; each possess guanine nucleotide exchange activity (GEF) on heterotrimeric G-proteins, but with different Gα subunits specificities. To gain insight on the mechanisms involved in RIC-8 cellular functions it is essential to obtain some information about its structure. Therefore, the aim of this thesis was to study the relationship between structure and function on RIC-8, using as model RIC-8 from X. laevis. Analysis in its primary structure did not give us information about the function of xRIC-8 and RIC-8 proteins were showed as a single family without similarity with others. For this reason, to obtain a 3D model of xRIC-8, different bioinformatics approaches that include protein folding and structure prediction were used. The RIC-8 structural model is composed of 10 armadillo folding motifs, organized in a right-twisted alpha-alpha super helix. In order to validate the structural model, a His-tag fusion construct of RIC-8 was expressed in E. coli, purified by affinity and anion exchange chromatography and subjected to circular dichroism analysis (CD) and thermostability studies. This model together with the comparison among RIC-8 proteins that shows a high conservation in the carboxy region, deletion mutants that remove the last three armadillo domain were created in order to search a loss of the GEF function. The mutants could not be expressed in bacteria for in vitro assays, but their expression in HEK293T culture showed that all of them preserved the GEF activity. Furthermore, confocal microscopy showed that all the mutants could translocate to plasmatic membrane under stimulation with isoproterenol, and have the capacity to interact with Gs. The results of this thesis has allowed present the first 3D model for a RIC-8 protein, as well as classify RIC-8 as a new member of the protein family with armadillo repeats. Functionally, the carboxi terminal region, the most conserved among RIC-8, did not show has the GEF activity, and did not alter its behavior in HEK293T cell cultures while was stimulated with isoproterenol. [less ▲]

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See detailTwo new species of Syncesia (Arthoniales, Roccellaceae) from Africa
Ertz, Damien; Killmann, Dorothee; Razafindrahaja, Tahina et al

in Lichenologist (2010), 42

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See detailLa muerte hermenéutica de Miguel Hernández
Becerra Mayor, David ULg

in Revista de Critica Literaria Marxista (2010), 4

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See detailNeural substrates of recollection and familiarity in Alzheimer’s disease
Genon, Sarah ULg; Salmon, Eric ULg; Collette, Fabienne ULg et al

in Proceedings of the 16th annual meeting of the Organization for Human Brain Mapping (2010)

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See detailLes corrélats cérébraux de le recollection et de la familiarité dans la maladie d’Alzheimer
Genon, Sarah ULg; Salmon, Eric ULg; Collette, Fabienne ULg et al

in Proceedings du XIeme colloque international sur le vieillissement cognitif (2010)

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See detailDéontologie des enseignements et formateurs
Leclercq, Dieudonné ULg; Poumay, Marianne ULg; Faulx, Daniel ULg et al

Learning material (2010)

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See detailQuaternary prevention: a task of the general practitioner.
Kuehlein, Thomas; Sghedoni, Donatella; Visentin, Giorgio et al

in Primary Care (2010), 18

Quaternary prevention – an (increasingly) important theme in family medicine “Prevention is better than cure”. This principle is undisputed. New knowledge points to the fact that prevention can also do ... [more ▼]

Quaternary prevention – an (increasingly) important theme in family medicine “Prevention is better than cure”. This principle is undisputed. New knowledge points to the fact that prevention can also do harm. Under the concept “quaternary prevention” efforts are currently focused on finding the right measure of preventive care, true to the old medical tenet “primum non nocere”. The Editors of PrimaryCare have pleasure in joining this trailblazing new discussion via the article of Thomas Kuehlein et al., which in its present form is based on Marc Jamoulle’s workshop “About quaternary prevention” at the European Wonca Congress 2009 in Basel. We publish it unabridged. The contribution appeared in several languages, and can be found in English, Spanish, Italian, Portuguese and Croatian at www.primary-care.ch. [less ▲]

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See detailSpecial issue dedicated to the second "AutoMathA conference"
Bruyère, Véronique; Pin, Jean-Eric; Restivo, Antonio et al

in Discrete Mathematics & Theoretical Computer Science (2010), 12

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See detailCompte-rendu de l'ouvrage de A. Beyaert-Geslin : L'image préoccupée
Dondero, Maria Giulia ULg

in Questions de Communication (2010), 17

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See detailIntérêt du dosage des sulfamidés hypoglycémiants: de la vérification de la compliance au diagnostic différentiel des hyperinsulinismes
Denooz, Raphael ULg; Charlier, Corinne ULg

in Revue Médicale de Liège (2010), 65(9), 493-497

Plus de cinquante ans après leur mise sur le marché, les sulfamidés hypoglycémiants font toujours partie du traitement de base du diabète non insulinodépendant. A côté de leurs remarquables propriétés ... [more ▼]

Plus de cinquante ans après leur mise sur le marché, les sulfamidés hypoglycémiants font toujours partie du traitement de base du diabète non insulinodépendant. A côté de leurs remarquables propriétés pharmacologiques, ces produits ont, à différentes reprises, été tenus responsables d’hypoglycémies sévères survenant de manière inexpliquée chez des sujets non diabétiques. Ce type d’hypoglycémie, qualifiée de factice, est notamment fréquemment retrouvée dans le syndrome de Munchausen, trouble psychiatrique poussant le malade à mimer une pathologie. Cette hypoglycémie est associée à un hyperinsulinisme endogène simulant une pathologie endocrine très rare, l’insulinome. Nous souhaitons faire connaître aux Cliniciens l’intérêt de la recherche et du dosage sanguin des sulfamidés hypoglycémiants dans le cadre du diagnostic différentiel des hyperinsulinismes. La mise en évidence d’une hypoglycémie induite par ces médicaments constitue un élément intéressant pour orienter le diagnostic et éventuellement éviter une pancréatectomie en cas de forte suspicion d’insulinome. La méthode analytique développée au laboratoire s’appuie sur la chromatographie liquide ultra performante couplée à la spectrométrie de masse tandem (UPLC -MS -MS ). Par cette technique, on peut mettre en évidence dans le sang une dizaine de sulfonylurées et le répaglinide. Elle constituera à l’avenir une méthode de choix face à toute suspicion de mésusage des sulfonylurées. [less ▲]

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See detailInfluence de la modalité visuelle sur l'évaluation acoustique de salles
Defays, Aurore ULg; Safin, Stéphane ULg; Billon, Alexis ULg et al

in Actes du 45ème congrès de la Société d'ergonomie de langue française. (2010)

Le projet AURALIAS vise à développer un environnement immersif permettant le travail coopératif entre architectes et acousticiens. Ce système associe donc un rendu sonore 3D et une vue du modèle 3D de la ... [more ▼]

Le projet AURALIAS vise à développer un environnement immersif permettant le travail coopératif entre architectes et acousticiens. Ce système associe donc un rendu sonore 3D et une vue du modèle 3D de la salle considérée. Dans ce cadre, nous nous intéressons à l’impact de l’image projetée sur le jugement subjectif de l’acoustique de la salle. 70 sujets ont été confrontés à une tâche de jugement du degré de réverbération d’un extrait sonore dans une situation contrôle (sans image) puis dans une situation expérimentale avec, pour la première partie des sujets, une image visant à soutenir le jugement (cohérente avec le son), pour la deuxième partie, une image « distractrice », et pour la troisième partie, sans image (groupe témoin). Nos résultats montrent une influence positive des images évocatrices et pas d’effet des images distractrices. [less ▲]

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See detailL'acquisition immobiliere internationale
Wautelet, Patrick ULg

in Guide de droit immobilier (2010)

In this chapter an attempt is made to describe the law of cross-border real estate acquisition. This is done first by analyzing the cross-border real estate sale (looking in particular at which law ... [more ▼]

In this chapter an attempt is made to describe the law of cross-border real estate acquisition. This is done first by analyzing the cross-border real estate sale (looking in particular at which law applies to the substance of the real estate agreement and what requirements apply in order to conclude a valid agreement as to the formal requirements). In a second stage, an analysis is made of the legal aspects of real estate financing, looking at the impact of mandatory provisions regarding mortgage lending. In a final chapter, some thoughts are offered on the securities used to back up mortgage lending, in particular the use of mortgage in cross border real estate acquisition. [less ▲]

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