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See detailTransmitted drug resistance, selection of resistance mutations and moderate antiretroviral efficacy in HIV-2: analysis of the HIV-2 Belgium and Luxembourg database.
Ruelle, jean; Roman, francois; Vandenbroucke, Anne-Thérèse et al

in BMC Infectious Diseases (2008), 8

BACKGROUND: Guidelines established for the treatment of HIV-1 infection and genotype interpretation do not apply for HIV-2. Data about antiretroviral (ARV) drug efficacy and resistance mutations is scarce ... [more ▼]

BACKGROUND: Guidelines established for the treatment of HIV-1 infection and genotype interpretation do not apply for HIV-2. Data about antiretroviral (ARV) drug efficacy and resistance mutations is scarce. METHODS: Clinical data about HIV-2 infected patients in Belgium and Luxembourg were collected and the effect of ARV therapy on plasma viral load and CD4 counts were analysed. Viral RNA encoding for protease (PR) and reverse transcriptase (RT) from ARV-naive and treated patients were sequenced. RESULTS: Sixty-five HIV-2 infected patients were included in this cohort. Twenty patients were treated with 25 different ARV combinations in a total of 34 regimens and six months after the start of ARV therapy, only one third achieved viral load suppression. All of these successful regimens bar one contained protease inhibitors (PIs). Mean CD4 gains in the group of viral load suppressors and the group of patients treated with PI-containing regimens were respectively significantly higher than in the group of non-suppressors and the group of PI-sparing regimens. The most frequent mutations selected under therapy (compared to HIV-2 ROD) were V71I, L90M and I89V within PR. Within RT, they were M184V, Q151M, V111I and K65R. All of these mutations, except K65R and M184V, were also found in variable proportions in ARV-naive patients. CONCLUSION: Despite a high rate of ARV treatment failure, better virological and immunological results were achieved with PI-containing regimens. The analysis of polymorphic positions and HIV-2 specific mutations selected during therapy showed for the first time that transmission of drug resistant viruses has occurred in Belgium and Luxembourg. The high heterogeneity in ARV combinations reflects a lack of guidelines for the treatment of HIV-2 infection. [less ▲]

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See detailBotulisme bij melkvee : voedselveiligheidsaspecten en maatregelen.
Van Huffel, X.; Cardoen, S.; Imberechts, H. et al

in Vlaams Diergeneeskundig Tijdschrift (2008), 78

aar aanleiding van enkele uitbraken van botulisme bij melkvee in België gedurende de laatste jaren worden in dit artikel de voedselveiligheidsaspecten die daaraan verbonden zijn nader besproken evenals de ... [more ▼]

aar aanleiding van enkele uitbraken van botulisme bij melkvee in België gedurende de laatste jaren worden in dit artikel de voedselveiligheidsaspecten die daaraan verbonden zijn nader besproken evenals de maatregelen die kunnen genomen worden op het melkveebedrijf en in de voedselketen ter vrijwaring van de blootstelling van de consument aan eventuele gezondheidsrisico’s. Uit een kwalitatieve risicoevaluatieis gebleken dat het risico op overdracht van botulismetoxinen via verwerkte melk naar de consument zeer laag is. De fecale contaminatie van de uier en melk door Clostridium botulinum sporen kan in geval van type B daarentegen een risico op de ontwikkeling van botulisme bij gevoelige mensen vormen. Bovendien kunnen in rauwe en laag verhitte melk- en zuivelproducten toxinen worden geproduceerd na de ontkieming van deze sporen. [less ▲]

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See detailGHB measurement by GC-MS in blood, urine and gastric contents, following an acute intoxication in Belgium
Bodson, Quentin; Denooz, Raphael ULg; Serpe, Philippe ULg et al

in Acta Clinica Belgica (2008), 63

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See detailSkin protection creams in medical settings: successful or evil ?
Xhauflaire, Emmanuelle ULg; Macarenko, Elena; Denooz, Raphael ULg et al

in Journal of Occupational Medicine and Toxicology (London, England) (2008), 3

ABSTRACT: BACKGROUND: Chronic exposure to mild irritants including cleansing and antiseptic products used for hand hygiene generates insults to the skin. To avoid unpleasant reactions, skin protection ... [more ▼]

ABSTRACT: BACKGROUND: Chronic exposure to mild irritants including cleansing and antiseptic products used for hand hygiene generates insults to the skin. To avoid unpleasant reactions, skin protection creams are commonly employed, but some fail to afford protection against a variety of xenobiotics. In this study, two skin protection creams were assayed comparatively looking for a protective effect if any against a liquid soap and an alcohol-based gel designed for hand hygiene in medical settings. METHODS: Corneosurfametry and corneoxenometry are two in vitro bioessays which were selected for their good reproducibility, sensitivity and ease of use. A Kruskal-Wallis ANOVA test followed by the Dunn test was realized to compare series of data obtained. RESULTS: Significant differences in efficacy were obtained between the two assayed skin protection creams. One of the two tested creams showed a real protective effect against mild irritants, but the other tested cream presented an irritant potential in its application with mild irritants. CONCLUSION: The differences observed for the two tested skin protection creams were probably due to their galenic composition and their possible interactions with the offending products. As a result, the present in vitro bioassays showed contrasted effects of the creams corresponding to either a protective or an irritant effect on human stratum corneum. [less ▲]

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See detailCharacteristics and expectations of patients with erectile dysfunction: results of the SCORED
Claes, Hubert; Opsomer, Reinier; Andrianne, Robert ULg et al

in International Journal of Impotence Research: The Journal of Sexual Medicine (2008)

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See detailEvolution of mechanical properties and final textural properties of resorcinol-formaldehyde xerogels during ambient air drying
Léonard, Angélique ULg; Blacher, Silvia ULg; Crine, Michel ULg et al

in Journal of Non-Crystalline Solids (2008), 354(10-11), 831-838

Porous carbon xerogels can be obtained by convective drying of resorcinol (R)-formaldehyde (F) hydrogels, followed by pyrolysis. Drying conditions have to be carefully controlled when crack-free monoliths ... [more ▼]

Porous carbon xerogels can be obtained by convective drying of resorcinol (R)-formaldehyde (F) hydrogels, followed by pyrolysis. Drying conditions have to be carefully controlled when crack-free monoliths with well-defined shape and size are required. The knowledge of the mechanical properties of the RF xerogels and their evolution with water content is essential to model their thermo-hygro-mechanical behavior during convective drying and avoid mechanical stresses leading to deformation and cracking of the sample. The shrinkage behavior and the mechanical properties of RF xerogels obtained with R/C ratio ranging from 300 to 1500 were investigated. R/C greatly influences the shrinkage and mechanical properties of the wet gel, on the one hand, and the mechanical and textural properties of the dried gel, on the other hand. The smaller the R/C, the higher the shrinkage, the stiffening, and the viscoelastic character of the xerogels. Water content has an influence on both the stiffness of the gels and the viscoelastic response. Generally, samples lose their mechanical viscous character and become more rigid when they are dried. Finally., mercury porosimetry measurements showed that the gels exhibit a marked lowering of their stiffness upon compression, interpreted as a result of the heterogeneity of the microstructure. (C) 2007 Elsevier B.V. All rights reserved. [less ▲]

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See detailSupported ATRP of fluorinated methacrylates in supercritical carbon dioxide : preparation of scCO2 soluble polymers with low catalytic residues
Grignard, Bruno ULg; Calberg, Cédric ULg; Jérôme, Christine ULg et al

in Chemical Communications (2008), (44), 5803-5805

Synthesis of poly( 2,2,2-trifluoroethyl methacrylate) by supported ATRP was investigated in supercritical carbon dioxide using a copper salt ligated to a polymeric ligand immobilised onto silica; after ... [more ▼]

Synthesis of poly( 2,2,2-trifluoroethyl methacrylate) by supported ATRP was investigated in supercritical carbon dioxide using a copper salt ligated to a polymeric ligand immobilised onto silica; after polymerisation, fluorinated polymers with well defined molecular weight and low polydispersity were obtained. [less ▲]

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See detailLes litiges contractuels transfrontaliers – le domaine résiduel du droit international privé : le droit belge
Wautelet, Patrick ULg

in Defossez, Michel; Senechal, Juliette (Eds.) Enforcing contracts. Aspects procéduraux de l'exécution des contrats transfrontaliers en droit européen et international Les litiges contractuels transfrontaliers (2008)

This paper gives a critical overview of the rules of private international law to be found in the Code of Private International Law adopted in Belgium in 2004 in relation to cross-border commercial ... [more ▼]

This paper gives a critical overview of the rules of private international law to be found in the Code of Private International Law adopted in Belgium in 2004 in relation to cross-border commercial contracts. These rules apply in a marginal number of cases due to the priority enjoyed by European rules (such as those found in the Brussels I Regulation and the Rome I Regulation). Nonetheless it is important to analyze whether these rules are well drafted. The analysis reveals serious shortcomings mainly in relation to rules of jurisdiction. On the one hand, the rule pertaining the choice of court agreements gives courts an unnecessary margin of discretion to disregard the agreement of parties. On the other hand, the rule pertaining to the law applicable to agreements, is outdated and based on archaic method of identifying the applicable law. [less ▲]

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See detailJuridiction ordinaire et juridiction administrative en droit belge
Pâques, Michel ULg; Donnay, Luc ULg

in Ben Salah, Hafedh; Ridha Jenayah, Mohamed (Eds.) La justice administrative dans les pays du Maghreb, la réception du modèle européen (2008)

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See detailExenatide once weekly in type 2 diabetes.
Scheen, André ULg

in Lancet (2008), 372

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See detailIn situ observation of wall effects in activated carbon filters by X-ray microtomography
Léonard, Angélique ULg; Wullens, Hilda; Blacher, Silvia ULg et al

in Separation & Purification Technology (2008), 64(1), 127-130

X-ray microtomography is a powerful non-invasive visualisation technique which can be advantageously used to get a better understanding or dynamic adsorption processes. In the present work, this technique ... [more ▼]

X-ray microtomography is a powerful non-invasive visualisation technique which can be advantageously used to get a better understanding or dynamic adsorption processes. In the present work, this technique is shown to be able to detect wall effects during the dynamic adsorption of methyl iodide on activated carbon filters. The analysis of transversal cross-sections along the filter height clearly shows the existence of radial concentration profiles. These radial adsorption profiles are directly linked to velocity profiles due to a higher permeability at the wall. Obtaining Such in situ information constitutes a real progress in order to validate simulation models allowing predicting reliable breakthrough times. (C) 2008 Elsevier B.V. All rights reserved. [less ▲]

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See detailDevelopment of a pharmacological protocol of stress echocardiography in horses
Sandersen, Charlotte ULg

in Annales de Médecine Vétérinaire (2008)

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See detailLes absences de longues durées pour lombalgie au sein du personnel soignant dans le secteur hospitalier
Vidick, Sarah ULg; Mairiaux, Philippe ULg

in Santé Publique : Revue Multidisciplinaire pour la Recherche et l'Action (2008), (Suppl. N° 3), 29-37

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See detailLes clauses statutaires d'agrément dans les S.P.R.L.: 'aménager n'est pas dénaturer'
Aydogdu, Roman ULg

in Journal des Tribunaux (2008)

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See detailLe systeme vasculaire lymphatique: etats des connaissances et implications dermatologiques potentielles.
Henno, Audrey ULg; Lapiere, ChM; Nusgens, Betty ULg et al

in Annales de Dermatologie et de Vénéréologie (2008), 135(10), 704-9

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