Publications ORBi OA
Bookmark and Share    
Full Text
See detailLe système immunitaire cutané et le photovieillissement
Nikkels, Arjen ULg; Tassoudji, Nazli ULg; Arrese Estrada, Jorge ULg et al

in Revue Médicale de Liège (1991), 46(3), 158-163

La connaissance du système immunitaire cutané a beaucoup progressé durant les dernières années. Considérée auparavant comme un organe passif de protection, on sait aujourd'hui que la peau est un organe ... [more ▼]

La connaissance du système immunitaire cutané a beaucoup progressé durant les dernières années. Considérée auparavant comme un organe passif de protection, on sait aujourd'hui que la peau est un organe immunocompétent. Le vieillissement cutané et l'exposition à la lumière ultraviolette ont une influence importante sur le système immunitaire cutané. Après une brève actualisation et description des cellules immunocompétentes de l'épiderme et du derme, nous considérerons la modulation du système immunitaire cutané liée au photovieillissement. [less ▲]

Detailed reference viewed: 28 (2 ULg)
Full Text
See detailRagged N-Termini and Other Variants of Class a Beta-Lactamases Analysed by Chromatofocusing
Matagne, André ULg; Joris, Bernard ULg; Van Beeumen, J. et al

in Biochemical Journal (1991), 273(273), 503-10

Four beta-lactamases excreted by Gram-positive bacteria exhibited microheterogeneity when analysed by chromatofocusing or ion-exchange chromatography. Ragged N-termini were in part responsible for the ... [more ▼]

Four beta-lactamases excreted by Gram-positive bacteria exhibited microheterogeneity when analysed by chromatofocusing or ion-exchange chromatography. Ragged N-termini were in part responsible for the charge variants, but deamidation of an asparagine residue was also involved, at least for the Bacillus licheniformis enzyme. The activity of a contaminating proteinase could also be demonstrated in the case of Actinomadura R39 beta-lactamase. With that enzyme, proteolysis resulted in partial inactivation, but the inactivated fragments were easily separated from the active forms. With these, as with the other enzymes, the kinetic parameters of the major variants were identical with those of the mixture within the limits of experimental error, so that the catalytic properties of these enzymes can be determined with the 'heterogeneous' preparations. [less ▲]

Detailed reference viewed: 6 (3 ULg)
Full Text
See detailRolling Experiments on a Floating Tidal Surge Barrier
Rigo, Philippe ULg

in Annual Meeting of the DPRI, University of Kyoto (1991, February)

Detailed reference viewed: 13 (1 ULg)
Full Text
See detailAnalyse qualitative de la modification de comportements d’enseignement par la technique de la ligne de base multiple
Cloes, Marc ULg; Piéron, Maurice ULg

in STAPS : Revue Internationale des Sciences du Sport et de l'Education Physique (1991), 24

Multiple baseline technique has been frequently related to success in teacher training. In this study, it was applied to change three enthusiastic behaviors by a pre-service teacher (hustles, dynamism ... [more ▼]

Multiple baseline technique has been frequently related to success in teacher training. In this study, it was applied to change three enthusiastic behaviors by a pre-service teacher (hustles, dynamism, feedback). The experimental design was planned for 20 weeks. It comprised 28 lessons and was divided into several phases (baseline, treatment, maintenance, follow up). The experimental design was successful as well in target behavior modification as in short - and long-terme stability of the changes. Qualitative analysis of the results provided useful information about the evolution of target behaviors. The procedure pointed out: (1) the specificity of the evolution of the behavioral changes; (2) the influence of various factors on the short term stability of the behavioral changes; (3) the influence of the duration of the treatment on the long term stability of the behavioral changes, and (4) the positive effects of a timely recall intervention. Data confirmed the reinforcing effect of a systematic follow up in teacher prepatation. [less ▲]

Detailed reference viewed: 50 (4 ULg)
Full Text
See detailThyrotropin-Secreting Pituitary Adenomas: Report of Seven Cases
Beckers, Albert ULg; Abs, R.; Mahler, C. et al

in Journal of Clinical Endocrinology and Metabolism (1991), 72(2), 477-83

Seven patients with hyperthyroidism due to a TSH-secreting pituitary macroadenoma have been observed of a total of 800 patients with pituitary tumors over a period of 15 yr. Serum TSH levels varied ... [more ▼]

Seven patients with hyperthyroidism due to a TSH-secreting pituitary macroadenoma have been observed of a total of 800 patients with pituitary tumors over a period of 15 yr. Serum TSH levels varied between 1.1-36.3 mU/L. The serum alpha-subunit level was low in 1 case, while in 4 other cases the concentration was elevated and varied between 3.7-7.8 micrograms/L. Serum TSH beta levels were normal in the 4 cases in which it was determined. Serum GH or PRL levels were elevated in 5 cases. In 1 patient the cosecretion of TSH, GH, and PRL was confirmed by immunocytochemical examination. Serum TSH and alpha-subunit responses to TRH, GnRH, CRF, GRF, dexamethasone, methimazole, T3, and bromocriptine administration were variable when studied. Serum TSH and alpha-subunit circadian rhythms were absent in 1 case and inverted in another. A serum alpha-subunit pulsatility without TSH pulses was observed in 1 patient. Five patients underwent transsphenoidal adenomectomy. Three of 4 patients operated on in our center were cured, but a recurrence of the adenoma was found in 1 of them after 5 yr. The fifth patient was not cured. Treatment with octreotide in 3 patients resulted in normalization of serum TSH, GH, and thyroid hormones levels. Cosecretion of PRL in 1 case and alpha-subunit in 2 cases was also inhibited. Partial tachyphylaxis occurred in 1 patient. In summary, heterogeneity in clinical presentation, hormonal expression, and therapeutic response appears to characterize these TSH-secreting adenomas. [less ▲]

Detailed reference viewed: 48 (0 ULg)
Full Text
See detailRapport de stage (jounalistique)
Olive, Gilles ULg

Report (1991)

Le groupe de Mr C. ROUSSEL fontionne autour de trois grands axes qui sont: - Les synthéses organiques chirales, - Les phases chromatographiques chirales, - Le projet CHIRBASE. Chacun de ces axes n'est pas ... [more ▼]

Le groupe de Mr C. ROUSSEL fontionne autour de trois grands axes qui sont: - Les synthéses organiques chirales, - Les phases chromatographiques chirales, - Le projet CHIRBASE. Chacun de ces axes n'est pas aussi indépendant qu'on pourrait le croire.On voit par exemple des synthéses de thiazolinethiones chirales qui serviront plus tard de phases stationnaires chirales. On constate quand même cette année plus de synthése achirale que de synthése chirale.Mais ceci est un fait exceptionnel. Quand au projet CHIRBASE, véritablement travail de fourmis qui consiste à rassembler le maximum de renseignements sur les séparations en HPLC de molécules chirales (séparation des énantioméres) afin d'être beaucoup plus efficace tout en gagnant du temps. La recherche pour comprendre les interactions entre une phase stationnaire passe par un plan d'expérience développé par le Professeur C. ROUSSEL, afin là aussi d'aller plus vite dans cette compréhension (bientôt sur les cyclodextrines). [less ▲]

Detailed reference viewed: 21 (0 ULg)
Full Text
See detailSerine Beta-Lactamases and Penicillin-Binding Proteins
Ghuysen, Jean-Marie ULg

in Annual Review of Microbiology (1991), 45

Detailed reference viewed: 24 (0 ULg)
Full Text
See detailLe dosage du récepteur circulant de la transferringe : une nouveauté pour quantifier l'érythropoïèse
Beguin, Yves ULg; Loo, M.; Fillet, Georges ULg

in Médecine et Hygiène (1991), 49

Les échanges de fer entre les tissus se font par l'intermédiaire de la transferrine plasmatique qui donne son fer aux cellules grâce à son interaction avec un récepteur mambranaire spécifique. Une forme ... [more ▼]

Les échanges de fer entre les tissus se font par l'intermédiaire de la transferrine plasmatique qui donne son fer aux cellules grâce à son interaction avec un récepteur mambranaire spécifique. Une forme soluble du récepteur de la transferrine a été mise en évidence dans le sang. Son dosage par méthode ELISA représente une excellente mesure quantitative de l'érythropoïèse qui devrait remplacer les méthodes anciennes moins fiables (réticulocytes) et plus complexes (tests au fer marqué). [less ▲]

Detailed reference viewed: 50 (1 ULg)
Full Text
See detailThe stratigraphy of the Middle Devonian in Belgium
Bultynck, P; Coen-Aubert, M; Godefroid, J et al

in Memoirs of the Geological Survey of Belgium (1991), 30

Detailed reference viewed: 10 (0 ULg)
Full Text
See detailAcyltransferase activities of the high-molecular-mass essential penicillin-binding proteins
Adam, Maggy; Damblon, Christian ULg; Jamin, Marc et al

in Biochemical Journal (1991), 279(Part 2), 601-604

The high-molecular-mass penicillin-binding proteins (HMM-PBPs), present in the cytoplasmic membranes of all eubacteria, are involved in important physiological events such as cell elongation, septation or ... [more ▼]

The high-molecular-mass penicillin-binding proteins (HMM-PBPs), present in the cytoplasmic membranes of all eubacteria, are involved in important physiological events such as cell elongation, septation or shape determination. Up to now it has, however, been very difficult or impossible to study the catalytic properties of the HMM-PBPs in vitro. With simple substrates, we could demonstrate that several of these proteins could catalyse the hydrolysis of some thioesters or the transfer of their acyl moiety on the amino group of a suitable acceptor nucleophile. Many of the acyl-donor substrates were hippuric acid or benzoyl-D-alanine derivatives, and their spectroscopic properties enabled a direct monitoring of the enzymic reaction. In their presence, the binding of radioactive penicillin to the PBPs was also inhibited. [less ▲]

Detailed reference viewed: 17 (2 ULg)
Full Text
See detailBibliography
Delrez, Marc ULg; Maes-Jelinek, Hena

in Maes-Jelinek, Hena (Ed.) Wilson Harris: The Uncompromising Imagination (1991)

Detailed reference viewed: 2 (0 ULg)
Full Text
See detailThe glucocorticoid receptor.
Muller, Marc ULg; Renkawitz, R.

in Biochimica et Biophysica Acta (1991), 1088

Detailed reference viewed: 8 (1 ULg)
Full Text
See detailSpatially continuous processing within a raster based GIS : some examples of geographical models
Donnay, Jean-Paul ULg; Binard, Marc ULg

in Bulletin de la Société belge de Géographie - SOBEG (1991), 2

La représentation d'un territoire en mode raster introduit une discrétisation qui peut être considérée, en première approximation, comme le résultat d'un échantillonnage à deux dimensions de cette surface ... [more ▼]

La représentation d'un territoire en mode raster introduit une discrétisation qui peut être considérée, en première approximation, comme le résultat d'un échantillonnage à deux dimensions de cette surface. Sous cette forme, un attribut spatialement continu constitue une couche de données directement accessible aux systèmes d'information géographique (S.I.G.) hybrides (raster/vecteur). Les avantages de cette représentation sont déjà exploités pour visualiser et traiter des phénomènes physiques surfaciques, tels que les modèles numériques de terrain. Une procédure identique peut être appliquée aux surfaces théoriques issues de l'application de modèles géographiques. En outre, les propriétés du mode raster sont susceptibles d'offrir des solutions graphiques soit plus simples, soit en l'absence de solutions analytiques. Cet article illustre ces avantages sur quelques modèles bien connus de l'analyse spatiale. [less ▲]

Detailed reference viewed: 27 (5 ULg)
Full Text
See detailDes zones industrielles aux sites d'affaires : l'affirmation d'un nouveau mode de localisation
Merenne-Schoumaker, Bernadette ULg

in Merenne-Schoumaker, Bernadette (Ed.) Les parcs d'activités économiques de la Province de Liège. Bilan et perspectives (1991)

Analysis of mutations occurring in the zones and business parks from 1960 to 1990

Detailed reference viewed: 9 (1 ULg)
Full Text
See detailLes parcs d'activités économiques en Province de Liège : un premier bilan
Merenne-Schoumaker, Bernadette ULg

in Merenne-Schoumaker, Bernadette (Ed.) Les parcs d'activités économiques de la Province de Liège : Bilan et perspectives (1991)

Review of 30 years of planning and management of business parks in the province of Liege

Detailed reference viewed: 17 (3 ULg)
Full Text
See detailMultiple domains of the glucocorticoid receptor involved in synergism with the CACCC box factor(s).
Muller, Marc ULg; Baniahmad, C.; Kaltschmidt, C. et al

in Molecular Endocrinology (Baltimore, Md.) (1991), 5(10), 1498-503

Steroid induction of responsive genes functions through the synergistic activity of steroid receptor-binding sequences with adjacent transcription factor-binding sites. To analyze the mechanism of synergy ... [more ▼]

Steroid induction of responsive genes functions through the synergistic activity of steroid receptor-binding sequences with adjacent transcription factor-binding sites. To analyze the mechanism of synergy we tested different human glucocorticoid receptor mutants for synergistic function with another transcription factor in comparison with intrinsic trans-activation obtained with a single receptor binding site (glucocorticoid response element). Multiple domains were found to be involved in synergistic activity of the glucocorticoid receptor with the CACCC box factor. Deletions within the N-terminal receptor half affected simultaneously intrinsic trans-activation and synergism. However, deletion of the hormone-binding domain mainly impaired synergism rather than intrinsic trans-activation, clearly showing that this domain synergizes by a mechanism independent of intrinsic activation. A chimeric protein where the DNA-binding domain of the glucocorticoid receptor was replaced by that of the yeast GAL4 protein also showed functional synergism. These data suggest that some of the receptor domains outside the DNA-binding domain synergize by their intrinsic trans-activating property, but the hormone-binding domain contributes to synergism by a different mechanism. [less ▲]

Detailed reference viewed: 22 (3 ULg)
Full Text
See detailThree-dimensional electron microscopy of ribosomal chromatin in two higher plants: a cytochemical, immunocytochemical, and in situ hybridization approach.
Motte, Patrick ULg; Loppes, Roland ULg; Menager, M. et al

in Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society (1991), 39(11), 1495-506

We report the 3-D arrangement of DNA within the nucleolar subcomponents from two evolutionary distant higher plants, Zea mays and Sinapis alba. These species are particularly convenient to study the ... [more ▼]

We report the 3-D arrangement of DNA within the nucleolar subcomponents from two evolutionary distant higher plants, Zea mays and Sinapis alba. These species are particularly convenient to study the spatial organization of plant intranucleolar DNA, since their nucleoli have been previously reconstructed in 3-D from serial ultra-thin sections. We used the osmium ammine-B complex (a specific DNA stain) on thick sections of Lowicryl-embedded root fragments. Immunocytochemical techniques using anti-DNA antibodies and rDNA/rDNA in situ hybridization were also applied on ultra-thin sections. We showed on tilted images that the OA-B stains DNA throughout the whole thickness of the section. In addition, very low quantities of cytoplasmic DNA were stained by this complex, which is now the best DNA stain used in electron microscopy. Within the nucleoli the DNA was localized in the fibrillar centers, where large clumps of dense chromatin were also visible. In the two plant species intranucleolar chromatin forms a complex network with strands partially linked to chromosomal nucleolar-organizing regions identified by in situ hybridization. This study describes for the first time the spatial arrangement of the intranucleolar chromatin in nucleoli of higher plants using high-resolution techniques. [less ▲]

Detailed reference viewed: 15 (2 ULg)