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See detailLe symbolique est le social
Durand, Pascal ULg; Dubois, Jacques; Winkin, Yves ULg

in Durand, Pascal; Dubois, Jacques; Winkin, Yves (Eds.) Le Symbolique et le Social. La réception internationale de la pensée de Pierre Bourdieu (2005)

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See detailRendre les choix technologiques négociables
Mormont, Marc ULg

Scientific conference (2005)

Les choix technologiques sont au coeur des controverses environnementales. Les rendre négociables est la seule option pour sortir des dilemmes politiques que les choix techniques proposent. mais cela ... [more ▼]

Les choix technologiques sont au coeur des controverses environnementales. Les rendre négociables est la seule option pour sortir des dilemmes politiques que les choix techniques proposent. mais cela implique de construire des dispositifs qui euvent aller jusqu'à la co-construction des technologies. [less ▲]

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See detailAnomalies des cellules de l'immunite naturelle et risque infectieux chez le patient diabetique
Moutschen, Michel ULg

in Revue Médicale de Liège (2005), 60(5-6, May-Jun), 541-4

This review addresses the recent litterature devoted to the risk of severe infections in patients with diabetes and to the potential influence of diabetes on the function of natural immunity. Although ... [more ▼]

This review addresses the recent litterature devoted to the risk of severe infections in patients with diabetes and to the potential influence of diabetes on the function of natural immunity. Although much controversy still exists regarding the incidence of infections in diabetic patients, several studies confirm that diabetes mellitus is associated with an increased severity and mortality in community acquired pneumonia. Furthermore, the risk of severe bacteremia (especially associated with Streptococcus pneumoniae) is higher in diabetic patients. Polynuclear neutrophils are clearly influenced by the diabetic state. On the one hand, their antimicrobial function is inhibited by hyperglycaemia, due to inhibition of G6PD or diversion of NADPH in the polyol pathway; on the other hand, the AGE/RAGE/NF-kappaB pathway involved in the pathogenesis of chronic complications of diabetes could also amplify inflammatory systemic manifestations associated with infections and play a role in the higher mortality rate observed in diabetic subjects with severe infections. These observations argue for the systematic vaccination of all diabetic patients against influenza and Streptococcus pneumoniae, for the reappraisal of diabetes as a significant pejorative risk factor in community acquired pneumonia and for intensive insulin therapy in all diabetic patients with severe infection. [less ▲]

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See detailSubdivision of the Famennian Stage into four substages and correlation with the neritic and continental Miospore Zonation
Streel, Maurice ULg

in Subcommission on Devonian Stratigraphy Newsletter (2005), 21

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See detailPour développer des actions locales : laisser s'exprimer le talent de chacun à l'intérieur d'un cadre stratégique
Coruble, Gérard; Vandoorne, Chantal ULg

in Promotion & Education (2005), 3

Developing local actions: allowing individual talents be expressed and utilised within a strategic framework. The Regional Health Programme of Children and Adolescents in Province Alpes Cote d'Azur (PRSJ ... [more ▼]

Developing local actions: allowing individual talents be expressed and utilised within a strategic framework. The Regional Health Programme of Children and Adolescents in Province Alpes Cote d'Azur (PRSJ), developed between March 1998 and May 1999, is characterised by its scope and complexity. It is more a strategic framework for action than an operational programme. To carry out this action, it was adapted to the level of intervention, on the one hand, using instruments at the regional level adapted for professional interventions, and,on the other hand, through the development of territory-based approaches founded on the creation of networks. Evaluations have shown that the actors found the framework proposed by PRSJ positive and adopted it. They expressed their creativity with more spontaneity in the networks with therapeutic objectives, than those responding to health determinants, which needed initial local support. Local communities appeared as the ideal setting for dissemination and stainability of PRSJ's objectives. PRSJ's strategic framework allowed local actors to express their talent. This mode of action, which accommodates not only programmatic focus within the context of practitioners on the ground, but also, epidemiology and socio-geographic interventions, are pertinent. To go beyond the explicit milestones set by the strategic orientations of the programme, different elements strengthening the framework are highlighted. [less ▲]

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See detailFrom DNA sequence analysis to modeling replication in the human genome
Brodie of Brodie, E. B.; Nicolay, Samuel ULg; Touchon, M. et al

in Physical Review Letters (2005), 94

We explore the large-scale behavior of nucleotide compositional strand asymmetries along hum chromosomes. As we observe for 7 of 9 origins of replication experimentally identified so far, the (TA GC) skew ... [more ▼]

We explore the large-scale behavior of nucleotide compositional strand asymmetries along hum chromosomes. As we observe for 7 of 9 origins of replication experimentally identified so far, the (TA GC) skew displays rather sharp upward jumps, with a linear decreasing profile in between two successi jumps. We present a model of replication with well positioned replication origins and random terminatio that accounts for the observed characteristic serrated skew profiles. We succeed in identifying 287 pairs putative adjacent replication origins with an origin spacing 1­2 Mbp that are likely to correspond replication foci observed in interphase nuclei and recognized as stable structures that persist througho subsequent cell generations. [less ▲]

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See detailDetermining the competence of mountainous Mediterranean streams using lichenometric techniques
Gob, F.; Jacob, N.; Bravard, J. P. et al

in International Association of Hydrological Sciences : “River Catchment Dynamics : Natural Processes and Human Impacts (2005)

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See detailEvaluation d'un cours en ligne : produit, usage et impact.
Georges, François ULg; Van de Poël, Jean-François ULg

in L'enseignement supérieur du XXIe siècle : de nouveaux défis à relever (2005)

Depuis 1999, le Laboratoire de Soutien à l’Enseignement Télématique accompagne des enseignants du supérieur et des formateurs d’adultes dans la mise en ligne de leur cours. Cet accompagnement a été et est ... [more ▼]

Depuis 1999, le Laboratoire de Soutien à l’Enseignement Télématique accompagne des enseignants du supérieur et des formateurs d’adultes dans la mise en ligne de leur cours. Cet accompagnement a été et est réalisé dans le cadre de projets subventionnés par la Région wallonne, la Communauté française et la Commission européenne. Une centaine de cours a été ainsi, en partie ou totalement, mise à distance. Les évaluations ont porté les premières années sur des critères davantage techniques et ergonomiques. Au fur et à mesure de notre expérience, nous nous sommes recentrés sur des critères purement d’ordre pédagogique ou tout au moins au service de l’apprentissage. Si au départ l’évaluation portait exclusivement sur un produit fini, elle tend au cours des années à s’instaurer dès la conception de l’outil et à porter donc également sur le processus (Dupont et Poumay, 2004). [less ▲]

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See detailLe diabete de l'enfant et de l'adolescent. 1. Prise en charge par le Service Universitaire de Pediatrie et la Cellule "Education-Diabete en Pediatrie"
LEBRETHON, Marie-Christine ULg; Philippart, D.; Rocour-Brumioul, D. et al

in Revue Médicale de Liège (2005), 60(5-6, May-Jun), 313-9

The management and follow up of diabetes in youth is a multidisciplinary challenge due to both short and long term objectives. Awareness of the feelings and problems faced by the families is critical. The ... [more ▼]

The management and follow up of diabetes in youth is a multidisciplinary challenge due to both short and long term objectives. Awareness of the feelings and problems faced by the families is critical. The experience of our team has started in the 1960s and is briefly described and updated in this article. [less ▲]

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See detailVariabilité spatio-temporelle de l’albédo. Analyse menée à la résolution métrique
Van Durme, G.; Erpicum, Michel ULg

in Bulletin de la Société Géographique de Liège (2005), 46

Albedo is a climatic factor that has been barely studied and thus is badly understood. However, it has a certain influence on our climate. This influence is especially visible in case of land use changes ... [more ▼]

Albedo is a climatic factor that has been barely studied and thus is badly understood. However, it has a certain influence on our climate. This influence is especially visible in case of land use changes, such as deforestation. The aim of the study presented in this paper is to increase the current knowledge on albedo and the factors that influence it. To achieve this, a field survey was conducted. Not all factors could be studied during the field campaign; among those that were effectively observed, the most important ones – those that were responsible for the biggest changes in albedo – were the development of vegetation, the presence of snow and the daily variation of the height of the sun. [less ▲]

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See detailLe controle de la transcription genique en tant que nouvelle cible therapeutique dans le traitement de l'asthme
Desmet, Christophe ULg; Louis, Renaud ULg; Lekeux, Pierre ULg et al

in Revue Médicale de Liège (2005), 60(10), 789-795

The recent advances in the knowledge of the molecular mechanisms underlying asthma have lead to a significant improvement of the current treatments of the disease and opened new perspectives for the ... [more ▼]

The recent advances in the knowledge of the molecular mechanisms underlying asthma have lead to a significant improvement of the current treatments of the disease and opened new perspectives for the development of therapeutic alternatives to inhaled corticosteroids. The selective targeting of transcription factors controlling the expression of the genes implicated in the pathogenesis of asthma is one of these privileged strategies. This review aims at describing the most promising new therapeutic targets in the control of asthmatic inflammation at the gene transcription level. [less ▲]

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See detailLe pied diabetique
Van Damme, Hendrik ULg; Limet, Raymond ULg

in Revue Médicale de Liège (2005), 60(5-6, May-Jun), 516-25

The pathophysiological mechanisms underlying a diabetic foot disease are complex and multifactorial, including neuropathy, ischemia, infection and abnormal foot biomechanics. All these factors are often ... [more ▼]

The pathophysiological mechanisms underlying a diabetic foot disease are complex and multifactorial, including neuropathy, ischemia, infection and abnormal foot biomechanics. All these factors are often intricated and source of delayed wound healing. Insight in the pathophysiology of the diabetic foot provides a comprehensive basis for a protocol of primary and secondary preventive care. Since non-enzymatic glycosilation of proteins and of connective tissue underlies structural changes in vessels, nerves and osteo-articular structures, a rigid control of blood glucose levels is of paramount importance. Early recognition of the etiology of foot lesions and prompt management of foot ulcers are essential for successful outcome. Aggressive treatment of infections, clinical assessment and correction of vascular occlusive disease (diabetic macroangiopathy), adequate wound care and appropriate off-loading (pressure relief) of the ulcer are essential steps in the treatment protocol. It is not surprising that optimal management of the diabetic foot requires a multidisciplinary approach in a Diabetic Foot Clinic, coordinating care-provisions by a team of diabetologist, infectiologist, vascular surgeon, interventional radiologist, plastic surgeon, podiatrist and specialized nurse. Applying evidence-based multidisciplinary treatment results in a 50% reduction of major lower-limb amputation in this high risk group. [less ▲]

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See detailParentification-Infantilisation
Stassart, Martine ULg

in Thérapie Familiale (2005), 26(1), 36-53

The research on the double bind context helps us understand the individuation process of mothers who are described as parentified and whose child seems to present borderline or psychotic problems. In a ... [more ▼]

The research on the double bind context helps us understand the individuation process of mothers who are described as parentified and whose child seems to present borderline or psychotic problems. In a previous paper, we presented a study on double bind between those mothers and their child. The aim of this present paper is to develop the transgenerational aspects of those family patterns. The paper will describe the individuation process of the parentifed mother based on the position she had in her own family, the way she grew up and progressively developed. We will examine her functions towards each of her parents and as well as towards her sibling. We will focus on different elements such as contact style, pat¬terns of interaction in the creation of an « experiencing world » that is so crucial in double bind process. This paper is the last of four. They all tried to expand the area of double bind by clarifyinging the Bateson's metaphor about the double bind as the only visible part of an iceberg. Further than a logical conceptual organization for double bind patterns, the aim of this paper is to provide therapists with a methodological tool they could use as a map which is co-created with the family to progressively reveal the gond reasons for this pathological situation to be and question its pertinence in the family today. [less ▲]

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See detailEULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 2: exploring decision rules for clinical utility
Conaghan, P.; D'Agostino, M. A.; Ravaud, P. et al

in Annals of the Rheumatic Diseases (2005), 64(12), 1710-1714

BACKGROUND: Synovial inflammation (as defined by hypertrophy and effusion) is common in osteoarthritis (OA) and may be important in both pain and structural progression. OBJECTIVE: To determine if ... [more ▼]

BACKGROUND: Synovial inflammation (as defined by hypertrophy and effusion) is common in osteoarthritis (OA) and may be important in both pain and structural progression. OBJECTIVE: To determine if decision rules can be devised from clinical findings and ultrasonography (US) to allow recognition of synovial inflammation in patients with painful knee OA. METHODS: A EULAR-ESCISIT cross sectional, multicentre study enrolled subjects with painful OA knee who had clinical, radiographic, and US evaluations. A classification and regression tree (CART) analysis was performed to find combinations of predictor variables that would provide high sensitivity and specificity for clinically detecting synovitis and effusion in individual subjects. A range of definitions for the two key US variables, synovitis and effusion (using different combinations of synovial thickness, depth, and appearance), were also included in exploratory analyses. RESULTS: 600 patients with knee OA were included in the analysis. For both knee synovitis and joint effusion, the sensitivity and specificity were poor, yielding unsatisfactory likelihood ratios (75% sensitivity, 45% specificity, and positive LR of 1.36 for knee synovitis; 71.6% sensitivity, 43.2% specificity, and positive LR of 1.26 for joint effusion). The exploratory analyses did not improve the sensitivity and specificity (demonstrating positive LRs of between 1.26 and 1.57). CONCLUSION: Although it is possible to determine clinical and radiological predictors of OA inflammation in populations, CART analysis could not be used to devise useful clinical decision rules for an individual subject. Thus sensitive imaging techniques such as US remain the most useful tool for demonstrating synovial inflammation of the knee at the individual level. [less ▲]

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See detailComment je préviens ... par des soins dermo-cosmetiques, l'expression d'une acné qui couve.
Pierard, Gérald ULg; Pierard, Claudine ULg

in Revue Médicale de Liège (2005), 60(9), 741-3

Acne is a disorder affecting the majority of subjects during adolescence that may persist at various grades of severity during adulthood. This disorder may manifest itself at different levels of severity ... [more ▼]

Acne is a disorder affecting the majority of subjects during adolescence that may persist at various grades of severity during adulthood. This disorder may manifest itself at different levels of severity ranging from discrete to severe. The lesions may be sporadic or follow a wild course. The therapeutic strategy depends on these progression characteristics and must fit to each individual patient. This review focuses on the minor but the most frequent types of acne that may benefit from dermocosmetic treatments. [less ▲]

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See detailLe formes "contingentes" en égyptien ancien : une catégorisation en question
Polis, Stéphane ULg

in Cannuyer, Christian (Ed.) La langue dans tous ses états (2005)

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See detailDAS28 best reflects the physician's clinical judgment of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score in patients under infliximab treatment
Cruyssen, B. V.; Van Looy, S.; Wyns, B. et al

in Arthritis Research & Therapy (2005), 7(5), 1063-1071

This study is based on an expanded access program in which 511 patients suffering from active refractory rheumatoid arthritis (RA) were treated with intravenous infusions of infliximab (3 mg/kg ... [more ▼]

This study is based on an expanded access program in which 511 patients suffering from active refractory rheumatoid arthritis (RA) were treated with intravenous infusions of infliximab (3 mg/kg+ methotrexate (MTX)) at weeks 0, 2, 6 and every 8 weeks thereafter. At week 22, 474 patients were still in follow-up, of whom 102 (21.5%), who were not optimally responding to treatment, received a dose increase from week 30 onward. We aimed to build a model to discriminate the decision to give a dose increase. This decision was based on the treating rheumatologist's clinical judgment and therefore can be considered as a clinical measure of insufficient response. Different single and composite measures at weeks 0, 6, 14 and 22, and their differences over time were taken into account for the model building. Ranking of the continuous variables based on areas under the curve of receiver-operating characteristic ( ROC) curve analysis, displayed the momentary DAS28 Disease Activity Score including a 28-joint count) as the most important discriminating variable. Subsequently, we proved that the response scores and the changes over time were less important than the momentary evaluations to discriminate the physician's decision. The final model we thus obtained was a model with only slightly better discriminative characteristics than the DAS28. Finally, we fitted a discriminant function using the single variables of the DAS28. This displayed similar scores and coefficients as the DAS28. In conclusion, we evaluated different variables and models to discriminate the treating rheumatologist's decision to increase the dose of infliximab (+MTX), which indicates an insufficient response to infliximab at 3 mg/kg in patients with RA. We proved that the momentary DAS28 score correlates best with this decision and demonstrated the robustness of the score and the coefficients of the DAS28 in a cohort of RA patients under infliximab therapy. [less ▲]

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See detailInterest of the use of electronic nose for field monitoring of odours in the environment
Nicolas, Jacques ULg

in Lehr Jay H.; Keeley Jack (Eds.) Water encyclopedia. Volume 2 : Water quality control. (2005)

Electronic nose is a promising technique for field monitoring of malodours in the environment. It is based on an array of non-specific gas sensors coupled with some form of mathematical data processing ... [more ▼]

Electronic nose is a promising technique for field monitoring of malodours in the environment. It is based on an array of non-specific gas sensors coupled with some form of mathematical data processing method to analyse the global response patterns. Some applications concerning the control of water quality are reported in the literature. They often impliy the generation of a headspace gas above liquid samples, but they also concern the odour emitted in the air from wastewater. The typical needs of the final user require both qualitative and quantitative approaches, i.e. both discriminating between slight variations in complex gas mixtures and monitoring a global odour signal which can be correlated with classical characterisation variables of water or air quality. Although potential applications in odour assessment by electronic noses are numerous, a number of challenges still need to be overcome: understanding and controlling the impact of environmental parameters (such as temperature and humidity), improving sensor sensitivity and noise reduction or developing calibration procedures to account for sensor drift. The present limitations of electronic nose technology restrict its use in the environment to the odour monitoring in the surroundings of the emission with instruments specifically designed for the application. [less ▲]

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See detailReprésentations de la figure de Charles Quint : des espoirs suscités aux traces dans une chronique française de la fin de sa vie. Comparaison de trois représentations : Molinet, Ladam, Le Blond
Dozo, Björn-Olav ULg

in Moyen français (Le). Revue d'études linguistiques et littéraires fondée par Giuseppe di Stefano (2005), 57-58

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