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See detailDifferent patterns of insulin resistance in relatives of type 1 diabetic patients with retinopathy or nephropathy
Hadjadj, S.; Pean, F.; Pean, F. et al

in Diabetes Care (2004), 27(11), 2661-2668

OBJECTIVE- Insulin resistance may be a risk factor for diabetic microangiopathy, which may have a familial component. We carried out a family-based study to determine which components of the insulin ... [more ▼]

OBJECTIVE- Insulin resistance may be a risk factor for diabetic microangiopathy, which may have a familial component. We carried out a family-based study to determine which components of the insulin resistance syndrome are associated with diabetic retinopathy and nephropathy in type 1 diabetes. RESEARCH DESIGN AND METHODS- The Genesis France-Belgium Study is a multicenter binational study designed to investigate the genetic factors involved in the microvascular complications of type 1 diabetes using a family-based design. Probands were type 1 diabetic patients with diabetic retinopathy (classified as background, preproliferative, or proliferative) and possibly diabetic nephropathy (absent, incipient, established, or advanced). The insulin resistance score of their first-degree relatives was calculated according to their BMI and history of arterial hypertension, lipid disorders, and type 2 diabetes. RESULTS- The insulin resistance score of relatives was positively correlated with the albumin excretion rate (P = 0.0009) and fasting plasma glucose (P = 0.0003) and HbA(1c) (P < 0.0001) concentrations. This score was higher in the relatives of probands with than in those without diabetic nephropathy (P = 0.0370). Similarly, it was higher in relatives of subjects with proliferative diabetic retinopathy than in those of probands without, even after controlling for subjects with versus without diabetic nephropathy (P = 0.0379). However, the components of the insulin resistance score in relatives differed according to the severity of diabetic retinopathy or nephropathy in the probands. Obesity and history of arterial hypertension were most common in relatives of probands with proliferative diabetic retinopathy, whereas obesity and history of lipid disorders were most common in the relatives of probands with diabetic nephropathy. CONCLUSIONS- Familial insulin resistance segregates with diabetic complications: lipid disorders and obesity segregate with diabetic nephropathy, whereas arterial hypertension and obesity segregate with diabetic retinopathy. [less ▲]

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See detailHuman chorionic gonadotropin and growth factors at the embryonic-endometrial interface control leukemia inhibitory factor (LIF) and interleukin 6 (IL-6) secretion by human endometrial epithelium
PERRIER d'HAUTERIVE, Sophie ULg; Charlet, Jeanne de Chantal ULg; Berndt, Sarah ULg et al

in Human Reproduction (2004), 19(11), 2633-2643

BACKGROUND: The elucidation of the molecular mechanisms by which the embryo contributes to its implantation is an area of extensive research. The main objective of this study was to investigate the ... [more ▼]

BACKGROUND: The elucidation of the molecular mechanisms by which the embryo contributes to its implantation is an area of extensive research. The main objective of this study was to investigate the pattern of leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) secretion by human endometrial epithelium, and their regulation by human chorionic gonadotropin (hCG) and other growth factors present at the embryonic-endometrial interface. METHODS: Endometrial epithelial cells (EEC) were isolated from biopsies collected at both proliferative and secretory phases of fertile women. RESULTS: HCG (1-50 IU/ml) increased LIF secretion by EEC cultures derived from follicular phase (up to 285+/-75%) or from secretory phase (up to 212+/-16%). In contrast, hCG reduced IL-6 secretion by EEC in both phases. The hCG/LH receptor gene was transcribed by EEC as evidenced by RT-PCR. Insulin-like growth factors 1 and 2 increased LIF secretion by EEC. Transforming growth factor beta1 stimulated LIF and reduced IL-6 secretion. CONCLUSIONS: Through hCG, the blastocyst may be involved in the control of its implantation (via an increase of proimplantatory LIF) and tolerance (via an inhibition of proinflammatory IL-6). Other growth factors present at the embryonic-endometrial interface are also involved in the control of LIF and IL-6 endometrial secretion. [less ▲]

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See detailLumiracoxib is effective in the treatment of osteoarthritis of the knee: a 13 week, randomised, double blind study versus placebo and celecoxib
Tannenbaum, H.; Berenbaum, F.; Reginster, Jean-Yves ULg et al

in Annals of the Rheumatic Diseases (2004), 63(11), 1419-1426

Objectives: To compare the efficacy and safety of lumiracoxib with placebo and celecoxib for osteoarthritis (OA) in a 13 week, multicentre, randomised, double blind study. Methods: After a 327 day washout ... [more ▼]

Objectives: To compare the efficacy and safety of lumiracoxib with placebo and celecoxib for osteoarthritis (OA) in a 13 week, multicentre, randomised, double blind study. Methods: After a 327 day washout period for non-steroidal anti-inflammatory drugs, 1702 patients with knee OA were randomised to lumiracoxib 200 or 400 mg once daily (od), celecoxib 200 mg od, or placebo (2:2:2:1). A visual analogue scale (VAS) pain intensity greater than or equal to40 mm was required. Primary efficacy variables were OA pain intensity (VAS mm) in the target knee, patient's global assessment of disease activity (VAS mm), and WOMAC pain subscale and total scores at 13 weeks. OA pain intensity, patient's and physician's global assessment of disease activity, and WOMAC (total and all subscale scores) were analysed by visit as secondary variables. Results: Lumiracoxib showed significant improvements in all primary and secondary variables compared with placebo. Lumiracoxib 200 mg od and celecoxib 200 mg od achieved similar improvements in OA pain intensity and functional status. Lumiracoxib 400 mg od demonstrated better efficacy for OA pain intensity and patient's global assessment of disease activity at weeks 2, 4, and 8 and similar efficacy at week 13 compared with celecoxib 200 mg od. The incidence of adverse events (AEs), serious AEs, and discontinuations due to AEs was similar in each group. Conclusion: Lumiracoxib demonstrated significant improvement in OA pain intensity, patient's global assessment of disease activity, and the WOMAC pain subscale and total scores compared with placebo. Lumiracoxib was well tolerated in this study, with overall tolerability similar to that of placebo and celecoxib. [less ▲]

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See detailCaractérisation de la farnésyle pyrophosphate synthase de pucerons
Beliveau, Catherine; Vandermoten, Sophie ULg; Francis, Frédéric ULg et al

Poster (2004, November)

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See detailComment j'explore... un syndrome polyuropolydipsique insipide
Schleich, FLorence ULg; Krzesinski, Jean-Marie ULg; Legros, Jean-Jacques ULg

in Revue Médicale de Liège (2004), 59(11), 664-668

The finding of a polyuropolydispsic syndrome should prompt a complete biological investigation of its etiology. If polyuria can be a minor sign as in psychiatric disorder, it can also be the first ... [more ▼]

The finding of a polyuropolydispsic syndrome should prompt a complete biological investigation of its etiology. If polyuria can be a minor sign as in psychiatric disorder, it can also be the first manifestation of diabetes mellitus but also central diabetes insipidus, the latter linked to cerebral tumors, metastases in the hypothalamus, granulomatous disease, but also nephrogenic diabetes insipidus such as chronic renal disease or autoimmune disease. Intracellular dehydration is the major risk in case of a polyuropolydipsic syndrome. Prognosis depends on the capacity to maintain water balance through an intact thirst mechanism. After a brief review of the majority of causes of diabetes insipidus, we propose a diagnosis algorithm to easily make the diagnosis. [less ▲]

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See detailIntegrating cognitive and collective aspects of work in evaluating technology
Nyssen, Anne-Sophie ULg

in IEEE Transactions on Systems Man and Cybernetics Part A-Systems and Humans (2004), 34(6), 743-748

Ergonomic criteria are receiving increasing attention from designers but their applications do not ensure that technology matches the user's abilities, needs, and work constraints. In this paper, we used ... [more ▼]

Ergonomic criteria are receiving increasing attention from designers but their applications do not ensure that technology matches the user's abilities, needs, and work constraints. In this paper, we used two series of studies conducted in the healthcare system to illustrate how important work analysis is in evaluating new technology in order to identify critical dimensions of work and anticipate the impact of the devices on these dimensions: one looking at a new automatic drug device for anesthetists and one at a new robotic surgery system. Given the results, we developed a methodology for evaluation of new technology in complex systems. The aim is to insist to assess the impacts of technology on all the dimensions of work: technical, performance, cognitive, organizational, and economic. Which dimensions and criteria will be developed more in detail depends on the results of the work analysis. [less ▲]

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See detailA Machine Learning Approach to Improve Congestion Control over Wireless Computer Networks
Geurts, Pierre ULg; El Khayat, Ibtissam; Leduc, Guy ULg

(2004, November)

In this paper, we present the application of machine learning techniques to the improvement of the congestion control of TCP in wired/wireless networks. TCP is suboptimal in hybrid wired/wireless networks ... [more ▼]

In this paper, we present the application of machine learning techniques to the improvement of the congestion control of TCP in wired/wireless networks. TCP is suboptimal in hybrid wired/wireless networks because it reacts in the same way to losses due to congestion and losses due to link errors. We thus propose to use machine learning techniques to build automatically a loss classifier from a database obtained by simulations of random network topologies. Several machine learning algorithms are compared for this task and the best method for this application turns out to be decision tree boosting. It outperforms ad hoc classifiers proposed in the networking literature. [less ▲]

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See detailImage du mois. Fibrodysplasie musculaire de l'artère rénale.
Gach, Olivier ULg; Pierard, Luc ULg; Legrand, Victor ULg

in Revue Médicale de Liège (2004), 59(11), 624-5

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See detailLa nación en los tiempos de la globalización: algunas tensiones en el discurso zapatista
Vanden Berghe, Kristine ULg

in Maihold, Günther (Ed.) Las modernidades de México. Espacios, procesos, trayectorias (2004, November)

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See detailDetermination of TGF-β1 plasma levels. Authors' reply
Barthelemy, Nicole ULg; De Jaeger, Katrien; SEPPENWOOLDE, Yvette et al

in International Journal of Radiation, Oncology, Biology, Physics (2004), 60(4), 1339

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See detailThe Articulation of “I”, “We” and the “Person”. Elements for an Anthropological Approach within Western and Islamic Contexts
Nachi, Mohamed ULg

in Dupret, Baudouin (Ed.) Standing Trial. Law and the Person in the Modern Middle East (2004, November)

Comment les éléments constitutifs de l'identité personnelle orientent-ils les jugements des individus, leur sens moral et leur perception du juste.

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See detailAre spatial memories strengthened in the human hippocampus during slow wave sleep?
Peigneux, Philippe ULg; Laureys, Steven ULg; Fuchs, Sonia et al

in Neuron (2004), 44(3), 535-545

In rats, the firing sequences observed in hippocampal ensembles during spatial learning are replayed during subsequent sleep, suggesting a role for posttraining sleep periods in the offline processing of ... [more ▼]

In rats, the firing sequences observed in hippocampal ensembles during spatial learning are replayed during subsequent sleep, suggesting a role for posttraining sleep periods in the offline processing of spatial memories. Here, using regional cerebral blood flow measurements, we show that, in humans, hippocampal areas that are activated during route learning in a virtual town are likewise activated during subsequent slow wave sleep. Most importantly, we found that the amount of hippocampal activity expressed during slow wave sleep positively correlates with the improvement of performance in route retrieval on the next day. These findings suggest that learning-dependent modulation in hippocampal activity during human sleep reflects the offline processing of recent episodic and spatial memory traces, which eventually leads to the plastic changes underlying the subsequent improvement in performance. [less ▲]

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See detailLa liberté de la presse a du plomb dans l'aile…
Durand, Pascal ULg

Article for general public (2004)

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See detailVers une analyse de la littérature francophone sur l’intervention en sport
Cloes, Marc ULg; Lenzen, Benoit; Trudel, Pierre

Poster (2004, October 23)

Les auteurs proposent une première analyse de la littérature francophone centrée sur la 'science du coaching'. Il s'agit d'une approche multidimensionnelle permettant d'identifier les principales ... [more ▼]

Les auteurs proposent une première analyse de la littérature francophone centrée sur la 'science du coaching'. Il s'agit d'une approche multidimensionnelle permettant d'identifier les principales caractéristiques des études publiées dans ce domaine de recherche en plein développement. [less ▲]

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See detailAnalyse de l'activité physique et sportive. Constats et réflexions
Cloes, Marc ULg

Conference given outside the academic context (2004)

Cet exposé vise à présenter les axes de recherche sur l'Interveniton en sport, suivis au sein du Service Intervention et Gestion en Activités physiques et sportives de l'Université de Liège.

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See detailInhibitory Effects of Proanthocyanidins from Ribes Nigrum Leaves on Carrageenin Acute Inflammatory Reactions Induced in Rats
Garbacki, Nancy ULg; Tits, Monique ULg; Angenot, Luc ULg et al

in BMC Pharmacology (2004), 4(1), 1-9

BACKGROUND: The anti-inflammatory effects of proanthocyanidins (PACs), isolated from blackcurrant (Ribes nigrum L.) leaves, were analysed using carrageenin-induced paw oedema and carrageenin-induced ... [more ▼]

BACKGROUND: The anti-inflammatory effects of proanthocyanidins (PACs), isolated from blackcurrant (Ribes nigrum L.) leaves, were analysed using carrageenin-induced paw oedema and carrageenin-induced pleurisy in rats. RESULTS: Pretreatment of the animals with PACs (10, 30, 60 and 100 mg/kg, i.p.) reduced paw oedema induced by carrageenin in a dose and time-dependent manner. PACs also inhibited dose-dependently carrageenin-induced pleurisy in rats. They reduced (A) lung injury, (B) pleural exudate formation, (C) polymorphonuclear cell infiltration, (D) pleural exudate levels of TNF-alpha, IL-1beta and CINC-1 but did not affect IL-6 and IL-10 levels. They reduced (E) pleural exudate levels of nitrite/nitrate (NOx). In indomethacin treated rats, the volume of pleural exudate was low, its content in leukocytes and its contents in TNF-alpha, IL-1beta, IL-6 and IL-10 but not in NOx were reduced. These data suggest that the anti-inflammatory properties of PACs are achieved through a different pattern from those of indomethacin. CONCLUSION: These results suggest that the main mechanism of the anti-inflammatory effect of PACs mainly lies in an interference with the migration of the leukocytes. Moreover, PACs inhibited in vivo nitric oxide release. [less ▲]

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See detailAn illumination device formed by cutting and laminating coated plates
Vandormael, Denis; Habraken, Serge ULg

Patent (2004)

An illumination device based on multi facet plastic optics is proposed.The fabrication principle is novative and based on specific cutting geometry and coating lamination

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See detailCombiner sport et études. Comment cela est-il vécu ?
Cloes, Marc ULg

Scientific conference (2004, October 16)

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See detailCommensal vs. parasitic relationship between Carapini fish and their hosts: some further insight through delta C-13 and delta N-15 measurements
Parmentier, Eric ULg; Das, Krishna ULg

in Journal of Experimental Marine Biology and Ecology (2004), 310(1),

In the Moorea Lagoon (French Polynesia), the pearlfish Carapus boraborensis, Carapus homei, Campus mourlani and Encheliophis gracilis are generally found inside echinoderm hosts such as the holothurian ... [more ▼]

In the Moorea Lagoon (French Polynesia), the pearlfish Carapus boraborensis, Carapus homei, Campus mourlani and Encheliophis gracilis are generally found inside echinoderm hosts such as the holothurian Bohadschia argus and the starfish Culcita novaeguineae. At the end of their larval stage, these fish settle on the reef and directly enter their echinoderm host where they undergo an important metamorphosis. The aim of this study was to get further insight on the type of symbiosis (commensal vs. parasite) between these fish and their hosts. delta(15)N and delta(13)C measurements were determined in the tissues of invertebrate hosts (holothurians and starfish) and carapids (larvae, juveniles and adults). The obtained isotopic signatures reveal different kinds of associations: metamorphosing larvae, juveniles and adults of C. boraborensis and C. homei do not feed at all oil host holothurian tissues, C mourlani and its asterian host display a commensal relationship without any feeding association, while E. gracilis is likely to feed on the tissue of the holothurian. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailNovel RGD-like molecules based on the tyrosine template design, synthesis, and biological evaluation on isolated integrins alpha(V)beta/alpha(IIb)beta(3) and in cellular adhesion tests
Biltresse, S.; Attolini, M.; Dive, Georges ULg et al

in Bioorganic & Medicinal Chemistry (2004), 12(20), 5379-5393

RGD (Arg-Gly-Asp) peptidomimetics have been designed for covalent anchorage on biomaterials. The tyrosine template was thus equipped with (i) a basic side chain of various flexibility, (ii) an acidic side ... [more ▼]

RGD (Arg-Gly-Asp) peptidomimetics have been designed for covalent anchorage on biomaterials. The tyrosine template was thus equipped with (i) a basic side chain of various flexibility, (ii) an acidic side chain, which incorporated the XPS fluorine tag, and (iii) a spacer-arm terminated by a primary amine for surface grafting. The most active compounds showed IC50 values in the nanomolar range versus isolated human integrins alpha(v)beta(3) and alpha(IIb)beta(3). Preincubation of CaCo2 cells with soluble peptidomimetics (2 and 19a) prevented cellular adhesion on culture plates coated with vitronectin. On the other hand, peptidomimetics (19a and 19b) immobilized on a poly(ethylene)terephthalate membrane (PET) promoted CaCo2 cells adhesion. A modeling study at the ab initio level in MINI-1' basis allowed to compare the various synthetic ligands of integrins and to propose novel pharmacophore structures. (C) 2004 Elsevier Ltd. All rights reserved. [less ▲]

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