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See detailInterférences entre phonologie et syntaxe en pathologie développementale du langage
Parisse, Christophe; Maillart, Christelle ULg

in Langage et l'Homme (Le) : Recherches Pluridisciplinaires sur le Langage (2006), 41

We compare three theories (pure phonological theory, surface theory, and mapping theory) about language developmental disorders considering that phonological difficulties are the main reason for the ... [more ▼]

We compare three theories (pure phonological theory, surface theory, and mapping theory) about language developmental disorders considering that phonological difficulties are the main reason for the children’s disorders. First, we identified the linguistic parameters (salience, phonological complexity, syntactic complexity, lexical/functional, semantic/syntactic) that are fundamental to these theories. Then we tested the validity of these parameters by testing them against results obtained by SLI children and control children. Nine syntactic categories were tested (determiner, noun, verb, etc.) No theory could fully explain the results obtained. Some linguistic parameters (eg. phonological complexity) are very interesting but fail to explain all results. Some other parameters (eg. salience) turned out to be inadequate to explain the results of French-speaking children. [less ▲]

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See detailThe left intraparietal sulcus and verbal short-term memory: Focus of attention or serial order ?
Majerus, Steve ULg; Poncelet, Martine ULg; Van der Linden, Martial ULg et al

in Neuroimage (2006), 32(2), 880-891

One of the most consistently activated regions during verbal short-term memory (STM) tasks is the left intraparietal sulcus (IPS). However, its precise role remains a matter of debate. While some authors ... [more ▼]

One of the most consistently activated regions during verbal short-term memory (STM) tasks is the left intraparietal sulcus (IPS). However, its precise role remains a matter of debate. While some authors consider the IPS to be a specific store for serial order information, other data suggest that it serves a more general function of attentional focalization. In the current fMRI experiment, we investigated these two hypotheses by presenting different verbal STM conditions that probed recognition for word identity or word order and by assessing functional connectivity of the left IPS with distant brain areas. If the IPS has a role of attentional focalization, then it should be involved in both order and item conditions, but it should be connected to different brain regions, depending on the neural substrates involved in processing the different types of information (order versus phonological/orthographic) to be remembered in the item and order STM conditions. We observed that the left IPS was activated in both order and item STM conditions but for different reasons: during order STM, the left IPS was functionally connected to serial/temporal order processing areas in the right IPS, premotor and cerebellar cortices, while during item STM, the left IPS was connected to phonological and orthographic processing areas in the superior temporal and fusiform gyri. Our data support a position considering that the left IPS acts as an attentional modulator of distant neural networks which themselves are specialized in processing order or language representations. More generally, they strengthen attention-based accounts of verbal STM. [less ▲]

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See detailLe bilan articulatoire et phonologique
Maillart, Christelle ULg

in Pierart, Bernadette; Estienne, Françoise (Eds.) L’évaluation du langage et de la voix. (2006)

Ce chapitre s’intéresse à l’évaluation des composants phonologiques du langage de l’enfant. Dans la première partie du chapitre, les caractéristiques phonétiques et phonologiques de la langue française ... [more ▼]

Ce chapitre s’intéresse à l’évaluation des composants phonologiques du langage de l’enfant. Dans la première partie du chapitre, les caractéristiques phonétiques et phonologiques de la langue française seront détaillées. Les fondements théoriques de l’évaluation phonologiques seront ensuite rapidement abordés avant de présenter plus longuement la double démarche, tant cognitive que linguistique, utilisée pour effectuer le diagnostic des troubles articulatoires et phonologiques. Nous reviendrons par la suite sur des éléments de diagnostic différentiel pour distinguer ces deux types de troubles puis nous terminerons en abordant les perspectives laissées ouvertes dans ce domaine. [less ▲]

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See detailComment je traite...des cors et des callosités.
Hermanns-Lê, Trinh ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2006), 61(7-8), 545-7

Corns and callosities are the expression of a peculiar aspect of mecanobiology of the foot. They are more frequent with ageing, particularly in women. These lesions represent a risk factor for the ... [more ▼]

Corns and callosities are the expression of a peculiar aspect of mecanobiology of the foot. They are more frequent with ageing, particularly in women. These lesions represent a risk factor for the diabetic foot. Prevention measures are important to follow in predisposed individuals. Several medicinal and non medicinal treatments have proven their efficacy. [less ▲]

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See detailLe pimecrolimus (Elidel) hors des sentiers battus.
Hermanns-Lê, Trinh ULg; Hermanns, Jean-François ULg; Thirion, Laurence et al

in Revue Médicale de Liège (2006), 61(4), 256-9

Pimecrolimus is an immune downregulator that belongs to the class of calcineurin inhibitors. Its efficacy is recognized for the topical treatment of the mild to moderate types of atopic dermatitis. In ... [more ▼]

Pimecrolimus is an immune downregulator that belongs to the class of calcineurin inhibitors. Its efficacy is recognized for the topical treatment of the mild to moderate types of atopic dermatitis. In addition, the drug shows activity in a series of other dermatitides. We report a review of the international literature about this topic. [less ▲]

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See detailComment j'explore... une perte de cheveux chez un patient cancéreux. Le trichogramme.
Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue de l’Association Belge des Technologues de Laboratoire = Tijdschrift van de Belgische Vereniging van Laboratoriumtechnologen (2006), 33

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See detailLe 17-butyrate d'hydrocortisone (Locoid), un trentenaire toujours innovateur.
Pierard, Gérald ULg

in Revue Médicale de Liège (2006), 61(2), 128-30

Since half a century, dermocorticoids represent worthy compounds in dermatological therapy. About thirty years ago, hydrocortisone 17-butyrate was introduced on the Belgian market. This compound combines ... [more ▼]

Since half a century, dermocorticoids represent worthy compounds in dermatological therapy. About thirty years ago, hydrocortisone 17-butyrate was introduced on the Belgian market. This compound combines good efficiency and reduced risk of side effects. Its topical formulations have been enriched over time. The original Locoid lipocream and Locoid Crelo presentations confer remarkable qualities to the product. We report a synopsis of clinical and translational studies devoted to this unique dermocorticoid. [less ▲]

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See detailComment je traite ... un psoriasis en plaques par l'association calcipotriol-dipropionate de betamethasone.
Henry, Frédérique ULg; Flagothier, Caroline ULg; Franchimont, Claudine ULg et al

in Revue Médicale de Liège (2006), 61(3), 139-41

The combination of calcipotriol and betamethasone dipropionate in a single topical formulation is a recent advance in treatment of plaque type psoriasis. Studies rooted on evidence-based medicine have ... [more ▼]

The combination of calcipotriol and betamethasone dipropionate in a single topical formulation is a recent advance in treatment of plaque type psoriasis. Studies rooted on evidence-based medicine have been recently published. We report a synthesis and a critical analysis, critical analysis of these investigations, and translate their data with a view to apply them in daily practice. [less ▲]

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See detailLe médicament du mois. L'étanercept (Enbrel) pour le traitement du psoriasis en plaques modéré a sévère.
Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2006), 61(3), 201-5

Etanercept (Enbrel) is a soluble tumour necrosis factor (TNF) receptor drug. By this mechanism, it inhibits the effects of TNF-alpha involved in the pathogenesis of psoriasis. Enbrel is approved for the ... [more ▼]

Etanercept (Enbrel) is a soluble tumour necrosis factor (TNF) receptor drug. By this mechanism, it inhibits the effects of TNF-alpha involved in the pathogenesis of psoriasis. Enbrel is approved for the treatment of moderate to severe chronic plaque psoriasis, and also for psoriatic arthritis. [less ▲]

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See detailL'image du mois. Lésions cutanées révélatrices d'une dermatomyosite.
Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2006), 61(4), 209-10

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See detailComment je traite...une dermite des langes.
Henry, Frédérique ULg; Thirion, Laurence; Franchimont, Claudine ULg et al

in Revue Médicale de Liège (2006), 61(4), 212-6

Diaper dermatitis is the most frequent skin disorder of the newborn. Several clinical types are distinguished. The most frequent type results from increased fragility of the newborn buttock skin when ... [more ▼]

Diaper dermatitis is the most frequent skin disorder of the newborn. Several clinical types are distinguished. The most frequent type results from increased fragility of the newborn buttock skin when covered by diapers. According to the mechanisms involved and the severity of the dermatitis, one can distinguish the intertrigo of the chubby baby, and the so-called "W", "Y" and "red panties" types of diaper dermatitis. When the effects of occlusion are not controlled by adequate absorption by the diapers maceration of the stratum corneum occurs. As a result, degradation of the skin barrier function takes place. In addition, the value of the coefficient of friction of the skin increases with epidermal weakening to rubbing. In addition, fecal enzymes alter urines and skin. Judicious hygiene measures and a correct choice of care and diapers are mandatory. Cutaneous colonisation by microorganisms, in particular the yeasts Candida spp, is the main complication. Adequate preventive and curative measures can combat diaper dermatitis with confidence. A miconazole paste allows to improve the tribological properties of the interface between diapers and the skin. It also corrects the degradation of the skin barrier function, reduces inflammation and abates the impact of Candida spp. in the pathogenesis of the skin disorder. [less ▲]

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See detailQualite de vie, emollients et agents hydratants.
Xhauflaire, Emmanuelle ULg; Haubrechts, C.; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2006), 61(4), 233-6

So-called dry skin is a quite common and annoying condition. This skin may affect individuals that are otherwise healthy. It may be particularly severe and unpleasant in cases of ichthyosis, atopic ... [more ▼]

So-called dry skin is a quite common and annoying condition. This skin may affect individuals that are otherwise healthy. It may be particularly severe and unpleasant in cases of ichthyosis, atopic dermatitis or psoriasis. The inductive effects of the environment must not be ignored. Emollients and hydrating agents for the stratum corneum can help relieve the clinical manifestations. [less ▲]

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See detailHighlighting the rim of the perifollicular epidermal unit.
Xhauflaire, Emmanuelle ULg; Hermanns, Jean-Francois; Pierard, Claudine ULg et al

in European Journal of Dermatology (2006), 16(3), 225-9

The perifollicular and interfollicular areas of normal skin may look similar. However, some physiological and pathological processes may specifically involve a thin perifollicular rim. This review ... [more ▼]

The perifollicular and interfollicular areas of normal skin may look similar. However, some physiological and pathological processes may specifically involve a thin perifollicular rim. This review illustrates some of the methods available for highlighting the rim of the perifollicular epidermal unit. Non invasive methods rely on dermoscopy, ultraviolet light enhanced visualization (ULEV), skin capacitance imaging and cyanoacrylate skin surface strippings (CSSS). Conventional histology and immunohistochemistry may also show specific perifollicular features without, however, revealing the aspects highlighted by the specific non invasive methods. The clinically relevant modifications consist of pigmentary and hyperkeratotic perifollicular changes. [less ▲]

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See detailL'herpes virus de type 6. Quelle attention mérite-t'il en medecine générale?
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2006), 61(5-6), 317-21

The human herpesvirus 6 (HHV6) is a member of the beta-herpes viridae family. The primary infection is usually asymptomatic and commonly occurs during childhood. The clinical form is called exanthema ... [more ▼]

The human herpesvirus 6 (HHV6) is a member of the beta-herpes viridae family. The primary infection is usually asymptomatic and commonly occurs during childhood. The clinical form is called exanthema subitum, or roseala infantum or the 6th disease. This biphasic disorder usually runs a benign course and requires no antiviral treatment. However, the HHV6 reactivation can lead to serious systemic diseases, especially encephalopathy, that may be fatal in the immunocompromised or grafted patient. In seronegative pregnant women, a primary HHV6 infection contracted from a child with roseola infantum can lead, in rare instances, to spontaneous abortion during the first trimester, or produce neurological complications in the newborn after HHV6 transplacental infection. Aciclovir, ganciclovir (GCV), foscarnet and cidofovir show anti-HHV6 in vitro efficacy, but GCV is currently the first line agent when of HHV6 infection is diagnosed in the immunocompromised patient. [less ▲]

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See detailL'herpes labial récidivant. Comment traiter et prévenir au mieux.
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2006), 61(5-6), 442-7

Labial herpes is a recurrent muco-cutaneous disorder caused by the herpes simplex virus (HSV), particularly the HSV type I. It affects 10 to 30% of the adult population. The recurrence rate varies from ... [more ▼]

Labial herpes is a recurrent muco-cutaneous disorder caused by the herpes simplex virus (HSV), particularly the HSV type I. It affects 10 to 30% of the adult population. The recurrence rate varies from episodic events to monthly recurrences. Several triggering factors have been identified. They include physical factors such as ultraviolet radiations and any local traumatism such as dental and neurosurgical interventions, and dermo-cosmetic procedures of the face. Hormonal factors are also involved including those related to menses and pregnancy. Psychogenic factors, particularly severe stress are also involved. Any other intercurrent infection may also be complicated by recurrent labial herpes. The management of recurrent labial herpes currently relies on the identification and possible avoidance of triggering factors, and on the use of antiviral agents. There is no curative treatment available so far. [less ▲]

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See detailL'image du mois. Ecthyma de l'adulte révélateur d'un diabète.
Thirion, L.; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2006), 61(7-8), 543-4

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See detailComment je previens...une exacerbation de la dermatite atopique.
Xhauflaire, Emmanuelle ULg; Pierard, Claudine ULg; Nikkels, Arjen ULg et al

in Revue Médicale de Liège (2006), 61(7-8), 600-3

Atopic dermatitis is under the influence of series of environmental factors. The contact with unsuited cleaning agents and rough textiles can exacerbate pruritus and inflammation. Preventive and adjuvant ... [more ▼]

Atopic dermatitis is under the influence of series of environmental factors. The contact with unsuited cleaning agents and rough textiles can exacerbate pruritus and inflammation. Preventive and adjuvant measures can thus help the care procedures of the disease. Appropriate hygiene measures and the use of emollients are particularly helpful. Clothing measures are also in place. Undergarments and pyjamas made of knitted natural silk are available. Other measures, sometimes corresponding to anecdotal claims--antihistamines, thermal cures, unconventional medicine, probiotics, chinese herbals, essential fatty acids--have not proven their preventive efficacy in atopic dermatitis. [less ▲]

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See detailL'image du mois: Maladie de Kaposi chez un sidéen africain.
Thirion, L.; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2006), 61(9), 609-10

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See detailLe cas clinique du mois. Carcinome basocellulaire pédicule et pigmenté: une présentation inhabituelle.
Azzam, C.; Arrese Estrada, Jorge ULg; Jacquemin, Denise ULg et al

in Revue Médicale de Liège (2006), 61(9), 614-6

Basal cell carcinomas (BCC) are the most common malignant neoplasms in humans. Clinical misdiagnoses are not uncommon. These cancers are classified according to their histological and clinical ... [more ▼]

Basal cell carcinomas (BCC) are the most common malignant neoplasms in humans. Clinical misdiagnoses are not uncommon. These cancers are classified according to their histological and clinical characteristics which exhibit distinct malignant behaviours. It is important to be aware of the different clinical presentations both for the accurate diagnosis and tumour management. We report the case of a 78-year-old man, who presented an unusual pedunculated and pigmented BCC. This combined aspect is rarely encountered. [less ▲]

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