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See detailIs cystatin C useful for the detection and the estimation of low glomerular filtration rate in heart transplant patients?
Delanaye, Pierre ULg; Nellessen, Eric ULg; Cavalier, Etienne ULg et al

in Transplantation (2007), 83(5), 641-644

Although previously studied in patients with chronic kidney disease, there is less data for the use of cystatin C and cystatin C-based formulas in heart transplant recipients. The ability of creatinine ... [more ▼]

Although previously studied in patients with chronic kidney disease, there is less data for the use of cystatin C and cystatin C-based formulas in heart transplant recipients. The ability of creatinine and cystatin C to detect renal failure (glomerular filtration rate [GFR] below 60 mL/min/1.73 m(2)) in heart transplant patients has been compared. The accuracy and precision of a creatinine-based formula (Modification of Diet in Renal Disease [MDRD]) versus a cystatin C-based formula (Rule's formula) to estimate GFR have also been studied. GFR was measured using the (51)Crethylenediamine tetraacetic acid tracer in 27 patients. There was no significant difference between GFR and the reciprocal of creatinine or cystatin C. Receiver operating characteristic curves for cystatin C and creatinine were similar. Both formulas were well correlated with the GFR. The bias of the cystatin C-based was significantly better than one of the MDRD formula, but the standard deviation appeared better for the MDRD formula (bias of +3.9 mL/min/1.73 m(2) versus +12 mL/min/1.73 m(2) and SD of 8.5 versus 11.6, respectively). Plasma cystatin C has no clear advantage over serum creatinine to detect renal failure in heart transplanted patients. [less ▲]

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See detailSex steroid dynamics during embryogenesis and sexual differentiation in Eurasian perch, Perca fluviatilis
Rougeot, Carole ULg; Krim, A.; Mandiki, S. N. et al

in Theriogenology (2007), 67(5), 1046-1052

It is widely accepted that sex steroid hormones play an important and a specific role during the process of sex differentiation in fish. In order to describe the role of the three main sex steroid ... [more ▼]

It is widely accepted that sex steroid hormones play an important and a specific role during the process of sex differentiation in fish. In order to describe the role of the three main sex steroid hormones (testosterone--T, 17beta-estradiol--E2 and 11keto-testosterone--11KT) during embryogenesis and sex differentiation in Eurasian perch, Perca fluviatilis, eggs, larvae and juveniles originating from two mixed-sex and two all-female progenies were regularly sampled from fertilization to hatching (D0) and from hatching to day 70 post-hatching (D70). Just after spawning, a significant amount of sex steroids [T (1634.2pgg(-1)), E2 (554.4pgg(-1)) and 11KT (1513.2pgg(-1))] was measured in non-fertilised eggs suggesting a maternal transmission of these steroids. From D2 to D70 post-hatching, E2 levels were significantly higher in mixed-sex progenies (median: 725.7pgg(-1)) than in all-female progenies (156.2pgg(-1)) and significantly increased after the onset of the histological differentiation of the gonad in both progenies (D35). Levels of 11KT were significantly higher in mixed-sex (median: 431.5pgg(-1)) than in all-female progenies (below the limit of assay detection) and significantly increased at D35 in all-female progenies (median value: 343.2pgg(-1)). Mean 11KT to E2 ratio was six-fold higher in mixed-sex progenies (1.35) than in all-female progenies (0.24). The data suggest that the 11-oxygenated androgen (11KT) plays a major role in the male differentiation process, and that sex differentiation in Eurasian perch is probably determined by the 11KT to E2 ratio. [less ▲]

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See detailCopolymers of epsilon-caprolactone and quaternized epsilon-caprolactone as gene carriers
Vroman, Benoît; Mazza, Michaël; Fernandez, Manuela R et al

in Journal of Controlled Release (2007), 118(1), 136-144

New copolymers of E-caprolactone (CL) and gamma-bromo-epsilon-caprolactone quaternized by pyridine (Py + CL) were investigated as non-viral vectors for gene delivery. Copolymers with two molar ... [more ▼]

New copolymers of E-caprolactone (CL) and gamma-bromo-epsilon-caprolactone quaternized by pyridine (Py + CL) were investigated as non-viral vectors for gene delivery. Copolymers with two molar compositions (50 Py + CL/50 CL and 80 Py + CL/20 CL), each with a diblock or a random structure, were used to prepare nanoparticulate complexes with DNA. Average size and surface charge of the complexes and extent of the complexation were measured. The DNA condensation by the copolymers was analysed by a gel retardation assay. Cytotoxicity and transfection efficiency of the copolymers were also evaluated in HeLa cells and compared with polyethylenimme 50 kDa. The size of the polyplexes was approximately 200 nm. The zeta potential first increased with the copolymer/DNA charge ratio and became positive for charge ratios in the 2-4 range depending on the type of copolymer. DNA was completely condensed within the nanoparticles and the degree of interaction was very high. Cytotoxicity and transfection efficiency were found to be comparable to polyethylenimine 50 kDa. The experimental results suggest that the novel copolymers can be used as novel gene delivery vectors. [less ▲]

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See detailLa chimie analytique : un rôle important de coopération avec l'Université d'Etat d'Haïti (FDS-FAMV)
Barthelemy, Jean-Paul ULg; Copin, Alfred

Scientific conference (2007, March 08)

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See detailTailoring of fine properties of biodegradable polyesters for biomedical applications
Lecomte, Philippe ULg

Scientific conference (2007, March 07)

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See detailCalcification and transparent exopolymer particles (TEP) production in batch cultures of Emiliania huxleyi exposed to different pCO2
De Bodt, Caroline; d'Hoop, Quentin; Harlay, Jérôme ULg et al

Poster (2007, March 06)

Ehux growth, calcification and related processes are sensitive to changes in initial pCO2. Our results show that the development of the Ehux cultures is delayed with increasing initial pCO2. TEP ... [more ▼]

Ehux growth, calcification and related processes are sensitive to changes in initial pCO2. Our results show that the development of the Ehux cultures is delayed with increasing initial pCO2. TEP accumulate until the end of the experiment and are enhanced after nutrient exhaustion. TEP contribute significantly to POC concentrations after the exponential growth phase. The very good correlation between TEP and calcite concentrations suggests that the calcification acts as a potential source of TEP in coccolithophore blooms. Finally, an Ωcalcite of 3 seems to be necessary for Ehux to calcify. [less ▲]

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See detailExozodiacal discs with infrared interferometry
Absil, Olivier ULg

Scientific conference (2007, March 05)

The detection of the warm inner part of debris discs---the extrasolar counterparts of the zodiacal cloud---is of prime importance to characterise the global architecture of planetary systems. Because of ... [more ▼]

The detection of the warm inner part of debris discs---the extrasolar counterparts of the zodiacal cloud---is of prime importance to characterise the global architecture of planetary systems. Because of the high contrast and small angular separation between the star and the exozodiacal light, high-precision infrared interferometry is the best-suited tool to carry out such observations. In this paper, we review the first detection of an exozodiacal disc by this method recently reported around Vega by Absil et al. (2006), and discuss the currently on-going observing efforts in this domain. We show how interferometric data can give access to the composition and the dynamics (including LHB-like events) of extrasolar planetary systems, and thereby put useful constraints on the presence of small bodies and/or giant planets. This statement is illustrated with new data obtained on various bright Vega-type stars, including Vega itself. Finally, we show how the new generation of interferometric instruments will change our view of debris discs: with their increased sensitivity and imaging capabilities, they will constrain the morphology of bright exozodiacal discs and push the detection limit towards meaningful density levels in the context of future life-finding missions such as Darwin/TPF. [less ▲]

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See detailLa censure a-t-elle disparu ?
Durand, Pascal ULg

Article for general public (2007)

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See detailDiscovery of Magnetic Fields in Slowly Pulsating B Stars
Hubrig, S.; Briquet, Maryline ULg; Schöller, M. et al

in Active OB-Stars: Laboratories for Stellar and Circumstellar Physics, ASP Conference Series, Vol. 361, Proceedings of the conference held 29 August - 2 September, 2005 at Hokkai-Gakuen University, Sapporo, Japan. (2007, March 01)

We present the first observations and conclusions of a magnetic survey with FORS 1 at the VLT of a sample of 25 Slowly Pulsating B stars. A clear mean longitudinal magnetic field of the order of a few ... [more ▼]

We present the first observations and conclusions of a magnetic survey with FORS 1 at the VLT of a sample of 25 Slowly Pulsating B stars. A clear mean longitudinal magnetic field of the order of a few hundred Gauss was detected in eleven SPBs. Among them several SPBs show a magnetic field that varies in time. It becomes clear that SPBs cannot be regarded anymore as non-magnetic stars. [less ▲]

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See detailCOSMOGRAIL: the COSmological MOnitoring of GRAvItational Lenses. V. The time delay in SDSS J1650+4251
Vuissoz, C.; Courbin, F.; Sluse, Dominique ULg et al

in Astronomy and Astrophysics (2007), 464

Aims.Our aim is to measure the time delay between the two gravitationally lensed images of the z_qso = 1.547 quasar SDSS J1650+4251, in order to estimate the Hubble constant H_0. Methods: Our measurement ... [more ▼]

Aims.Our aim is to measure the time delay between the two gravitationally lensed images of the z_qso = 1.547 quasar SDSS J1650+4251, in order to estimate the Hubble constant H_0. Methods: Our measurement is based on R-band light curves with 57 epochs obtained at Maidanak Observatory, in Uzbekistan, from May 2004 to September 2005. The photometry is performed using simultaneous deconvolution of the data, which provides the individual light curves of the otherwise blended quasar images. The time delay is determined from the light curves using two very different numerical techniques, i.e., polynomial fitting and direct cross-correlation. The time delay is converted into H[SUB]0[/SUB] following analytical modeling of the potential well. Results: Our best estimate of the time delay is Delta t = 49.5 ± 1.9 days, i.e., we reach a 3.8% accuracy. The R-band flux ratio between the quasar images, corrected for the time delay and for slow microlensing, is F_A/F[SUB]B[/SUB] = 6.2 ± 5%. Conclusions: .The accuracy reached on the time delay allows us to discriminate well between families of lens models. As for most other multiply imaged quasars, only models of the lensing galaxy that have a de Vaucouleurs mass profile plus external shear give a Hubble constant compatible with the current most popular value (H[SUB]0[/SUB] = 72 ± 8 km s[SUP]-1[/SUP] Mpc[SUP]-1[/SUP]). A more realistic singular isothermal sphere model plus external shear gives H[SUB]0[/SUB] = 51.7[SUP]+4.0[/SUP][SUB]-3.0[/SUB] km s[SUP]-1[/SUP] Mpc[SUP]-1[/SUP]. Table [see full text] is only available in electronic form at http://www.aanda.org [less ▲]

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See detailCHOP alone compared with CHOP plus radiotherapy for localized aggressive lymphoma in elderly patients: A study by the Groupe d'Etude des Lymphomes de I'Adulte
Bonnet, Christophe ULg; Fillet, Georges ULg; Mounier, N. et al

in Journal of Clinical Oncology (2007), 25(7), 787-792

Purpose Chemoradiotherapy has been considered standard treatment for patients with limited-stage aggressive lymphoma on the basis of trials conducted before the introduction of the International ... [more ▼]

Purpose Chemoradiotherapy has been considered standard treatment for patients with limited-stage aggressive lymphoma on the basis of trials conducted before the introduction of the International Prognostic Index. To evaluate this approach in elderly patients with low-risk localized lymphoma, we conducted a trial comparing chemoradiotherapy with chemotherapy alone. Patients and Methods Previously untreated patients older than 60 years with localized stage I or II histologically aggressive lymphoma and no adverse prognostic factors of the International Prognostic Index were randomly assigned to receive either four cycles of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) plus involved-field radiotherapy (299 patients) or chemotherapy alone with four cycles of CHOP (277 patients). Results With a median follow-up time of 7 years, event-free and overall survival did not differ between the two treatment groups (P =.6 and P =.5, respectively). The 5-year estimates of event-free survival were 61% for patients receiving chemotherapy alone and 64% for patients receiving CHOP plus radiotherapy; the 5-year estimates of overall survival were 72% and 68%, respectively. In a multivariate analysis, overall survival was affected by stage II disease (P <.001) and male sex (P =.03). Conclusion In this large prospective study, CHOP plus radiotherapy did not provide any advantage over CHOP alone for the treatment of low-risk localized aggressive lymphoma in elderly patients. [less ▲]

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See detail31 janvier : journée sur le projet de service
Grignard, Sophie; Vandoorne, Chantal ULg

in Promouvoir la Santé à l'Ecole (2007), (17), 2-4

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See detailLe syndrome de Hutchinson-Gilford (progeria): analyse clinique et moleculaire chez une patiente d'origine africaine
Mutesa, Léon; Pierquin, Geneviève ULg; Cwiny-Ay, N. et al

in Revue Médicale de Liège (2007), 62(3), 155-8

Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disease characterized by an early onset of several clinical features including premature ageing in children. Approximately 80% of ... [more ▼]

Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disease characterized by an early onset of several clinical features including premature ageing in children. Approximately 80% of HGPS cases are caused by a de novo single-base pair substitution c.1824 C>T (GGC > GGT, p.Gly608Gly) within the exon 11 of the LMNA gene which codes for lamins A and C proteins. This mutation creates an abnormal splice donor site, leading to the formation of a truncated lamin A protein. Only a very few cases of African patients with HGPS have been reported, but none of them has been characterized at the molecular level. We report here a 12 year-old-girl African patient with HGPS, in whom the p.Gly608Gly heterozygous disease-causing mutation was found. [less ▲]

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See detailLe medicament du mois. Olmesartan medoxomil hydrochlorothiazide (Olmetec Plus ou Belsar Plus)
Lancellotti, Patrizio ULg

in Revue Médicale de Liège (2007), 62(3), 175-9

The therapeutic control of hypertension is still a global challenge and frequently requires combination therapy. Olmesartan medoxomil hydrochlorothiazide (Olmetec plus, Belsar plus) is a fixed-dose ... [more ▼]

The therapeutic control of hypertension is still a global challenge and frequently requires combination therapy. Olmesartan medoxomil hydrochlorothiazide (Olmetec plus, Belsar plus) is a fixed-dose combination of olmesartan 20 mg and hydrochlorothiazide 12.5 or 25 mg. Olmesartan is a well known angiotensin II AT1 receptor blocker characterized by a good efficacy, a fast and prolonged duration of action and a placebo-like tolerability. With the combination therapy, no significant change of pharmacokinetics of either component is observed. The fixed-dose combination results in a greater blood pressure reduction compared to monotherapy with either component. This is at least effective as or even more effective than the combination of atenolol or losartan with hydrochlorothiazide, respectively. The responder rate is about 90%. The safety and tolerability remain excellent. Beyond the antihypertensive effect, olmesartan significantly reduces vascular inflammation and the wall-to-lumen ration in arteries. The starting dose is 20/12.5 mg. [less ▲]

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See detailProjecting Generation Decisions Induced by a Stochastic Program on a Family of Supply Curve Functions
Defourny, Boris ULg; Wehenkel, Louis ULg

Scientific conference (2007, March)

We propose to post-process the results of a scenario based stochastic program by projecting its decisions on a parameterized space of policies. By doing so the risk of overfitting to the set of scenarios ... [more ▼]

We propose to post-process the results of a scenario based stochastic program by projecting its decisions on a parameterized space of policies. By doing so the risk of overfitting to the set of scenarios used in the stochastic program is reduced. A proper choice of the structure of the space of policies allows one to exploit them in the context of novel scenarios, be it for Monte-Carlo based value estimation or for use in real-life conditions. These ideas are presented in the context of planning the exploitation of electric energy resources or for evaluating the economic value of a portfolio of assets. [less ▲]

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See detailThe role of deformation in the bouncing droplet problem
Terwagne, Denis ULg; Gilet, Tristan ULg; Dorbolo, Stéphane ULg et al

Poster (2007, March)

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