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See detailRecommandations sur la prise en charge de l'arthrose de la hanche et du genou. Pour qui ? Pourquoi ? Pour quoi faire ?
Henrotin, Yves ULg; Chevalier, X.

in Presse Médicale (2010)

This paper summarizes the guidelines published by the Osteoarthritis research society International(OARSI) and compares these guidelines with others. The OARSI guidelines are based on a systematic review ... [more ▼]

This paper summarizes the guidelines published by the Osteoarthritis research society International(OARSI) and compares these guidelines with others. The OARSI guidelines are based on a systematic review of the literature, a meta-analysis and an expert consensus. The OARSI has developed 25 guidelines including 8 for pharmacology modalities, 12 for non-pharmacology modalities and 5 for surgery modalities. The usefulness of the guidelines in the daily practice is very low. The barriers for the guidelines implementation are the lack of interest of the practitioners, the lack of scientific advances in the OA diagnosis and treatments and the low applicability of these guidelines in the daily practice. [less ▲]

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See detailBulk organic geochemistry of sediments from Puyehue Lake and its watershed (Chile, 40°S): Implications for paleoenvironmental reconstructions
Bertrand, Sébastien; Sterken, Mieke; Vargas-Ramirez, Lourdes et al

in Palaeogeography, Palaeoclimatology, Palaeoecology (2010), 294

Since the last deglaciation, the mid-latitudes of the southern Hemisphere have undergone considerable environmental changes. In order to better understand the response of continental ecosystems to ... [more ▼]

Since the last deglaciation, the mid-latitudes of the southern Hemisphere have undergone considerable environmental changes. In order to better understand the response of continental ecosystems to paleoclimate changes in southern South America, we investigated the sedimentary record of Puyehue Lake, located in the western piedmont of the Andes in South-Central Chile (40°S). We analyzed the elemental (C, N) and stable isotopic ([delta]13C, [delta]15N) composition of the sedimentary organic matter preserved in the lake and its watershed to estimate the relative changes in the sources of sedimentary organic carbon through space and time. The geochemical signature of the aquatic and terrestrial end-members was determined on samples of lake particulate organic matter (N/C: 0.130) and Holocene paleosols (N/C: 0.069), respectively. A simple mixing equation based on the N/C ratio of these end-members was then used to estimate the fraction of terrestrial carbon ([latin small letter f with hook]T) preserved in the lake sediments. Our approach was validated using surface sediment samples, which show a strong relation between [latin small letter f with hook]T and distance to the main rivers and to the shore. We further applied this equation to an 11.22 m long sediment core to reconstruct paleoenvironmental changes in Puyehue Lake and its watershed during the last 17.9 kyr. Our data provide evidence for a first warming pulse at 17.3 cal kyr BP, which triggered a rapid increase in lake diatom productivity, lagging the start of a similar increase in sea surface temperature (SST) off Chile by 1500 years. This delay is best explained by the presence of a large glacier in the lake watershed, which delayed the response time of the terrestrial proxies and limited the concomitant expansion of the vegetation in the lake watershed (low [latin small letter f with hook]T). A second warming pulse at 12.8 cal kyr BP is inferred from an increase in lake productivity and a major expansion of the vegetation in the lake watershed, demonstrating that the Puyehue glacier had considerably retreated from the watershed. This second warming pulse is synchronous with a 2 °C increase in SST off the coast of Chile, and its timing corresponds to the beginning of the Younger Dryas Chronozone. These results contribute to the mounting evidence that the climate in the mid-latitudes of the southern Hemisphere was warming during the Younger Dryas Chronozone, in agreement with the bipolar see-saw hypothesis. [less ▲]

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See detailUnified description of fission in fusion and spallation reactions
Mancusi, Davide ULg; Charity, R. J.; Cugnon, Joseph ULg

in Physical Review. C : Nuclear Physics (2010), 82

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See detailDeoxycitidine kinase is associated with prolonged survival after adjuvant gemcitabine for resected pancreatic adenocarcinoma.
Marechal, Raphael; Mackey, John R; Lai, Raymond et al

in Cancer (2010), 116(22), 5200-6

BACKGROUND: Gemcitabine (2',2'-difluorodeoxycytidine) administration after resection of pancreatic cancer improves both disease-free survival (DFS) and overall survival (OS). Deoxycytidine kinase (dCK ... [more ▼]

BACKGROUND: Gemcitabine (2',2'-difluorodeoxycytidine) administration after resection of pancreatic cancer improves both disease-free survival (DFS) and overall survival (OS). Deoxycytidine kinase (dCK) mediates the rate-limiting catabolic step in the activation of gemcitabine. The authors of this report studied patient outcomes according to the expression of dCK after a postoperative gemcitabine-based chemoradiation regimen. METHODS: Forty-five patients with resected pancreatic adenocarcinoma received adjuvant gemcitabine based-therapy in the context of multicenter phase 2 studies. Their tumors were evaluated retrospectively for dCK protein expression by immunohistochemistry. A composite score based on the percentage of dCK-positive cancer cells and the intensity of staining was generated, and the results were dichotomized at the median values. RESULTS: The median follow-up was 19.95 months (95% confident interval [CI], 3.3-107.4 months). The lymph node (LN) ratio and dCK protein expression were significant predictors of DFS and OS in univariate analysis. On multivariate analysis, dCK protein expression was the only independent prognostic variable (DFS: hazard ratio [HR], 3.48; 95% CI, 1.66-7.31; P = .001; OS: HR, 3.2; 95% CI,1.44-7.13; P = .004). CONCLUSIONS: dCK protein expression was identified as an independent and strong prognostic factor in patients with resected pancreatic adenocarcinoma who received adjuvant gemcitabine therapy. The authors concluded that it deserves prospective evaluation as a predictive biomarker for patient selection. [less ▲]

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See detailSartre et Althusser. Retour critique sur l'anti-humanisme
Caeymaex, Florence ULg

in Temps Modernes (Les) (2010), 658-659(avril-juin), 141-158

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See detailThymosin beta4 in multiple myeloma: friend or foe
Caers, Jo ULg; Otjacques, Eléonore ULg; Hose, Dirk et al

in Annals of the New York Academy of Sciences (2010), 1194(1), 125-130

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See detailTetracycline-controlled transgene activation using the ROSA26-iM2-GFP knock-in mouse strain permits GFP monitoring of DOX-regulated transgene-expression
Wortge, Simone; Eshkind, Leonid; Cabezas-Wallscheid, Nina et al

in BMC Developmental Biology (2010), 10

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See detailThymosin Beta 4 has tumor suppressive effects and its decreased expression results in poor prognosis and decreased survival in multiple myeloma
Caers, Jo ULg; Hose, Dirk; Kuijpers, Ine et al

in Haematologica (2010), 95(1), 163-167

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See detailExercices d'astronomie de position
Bidaine, Benoît ULg

Learning material (2010)

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See detailChimamanda Ngozi Adichie
Tunca, Daria ULg

Article for general public (2010)

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See detailUnit stream power as a base for regional river typology
Hallot, Eric ULg; Houbrechts, Geoffrey ULg; Levecq, Yannick et al

Poster (2010)

In order to assess the hydromorphological quality of surface waters, stakeholders need river typologies accurate and functional enough to be a really efficient management tool. From a typological study ... [more ▼]

In order to assess the hydromorphological quality of surface waters, stakeholders need river typologies accurate and functional enough to be a really efficient management tool. From a typological study based a broad set of hydromorphological field data, we have shown that some variables, like the unit stream power (), are particularly appropriate to describe the dynamics of a river. Initial results of repeated measurement in more than 80 sites revealed a regional differentiation based on critical values of stream power at bankfull discharge. The aim of this study is to present a unit stream power mapping for the whole network based on general equation  =  g Q S / w, with  the density of water, g the acceleration due to gravity, Q the discharge, S the slope and w the channel width). Slope is extracted from DEM. Bankfull discharge and width estimations are furnished by allometric equations using the watershed area. Different coefficients are used according to regional differentiations based on bedload size and watershed permeability. The statistical significance of all equations was tested by covariance analysis. A correction taking into account the used log-log scale, was also applied to the obtained allometric equations (Fergusson, 1988). Using a 30 x 30 meters DEM, GIS routines were developed. A first one automatically sectorizes the network and a second evaluates the unit streamspower in each location. We propose a 7-level classification in accordance with the associated morphological processes describe in the literature (from fixed meanders to step-pools system). The mapping unit starts at the Strahler second order. Our results not only support a regional typology, but moreover allow us to describe natural regions in function of river dynamics and to estimate the resistance of restoration works like vegetal techniques. It can also provide estimates of the excess stream power (the fraction of the actual stream power exceeding the power at which bedload particles start to move). (Fergusson, R.,I., 1988. River loads underestimated by rating curves, Water Resour. Res., 24(7), 1217–1219.) [less ▲]

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See detailThe contribution of familiarity to within- and between-domain associative recognition memory: Use of a modified remember/know procedure
Bastin, Christine ULg; Van der Linden, Martial ULg; Schnakers, Caroline ULg et al

in European Journal of Cognitive Psychology (2010), 22(6), 922-943

The purpose of the present study was to determine the extent to which familiarity can support associative recognition memory as a function of whether the associations are within- or between-domain ... [more ▼]

The purpose of the present study was to determine the extent to which familiarity can support associative recognition memory as a function of whether the associations are within- or between-domain. Standard recognition and familiarity only performance were compared in different participants, using a new adaptation of the remember/know procedure. The results indicated that within-domain (face face) associative recognition was mainly supported by familiarity. In contrast, familiarity provided relatively poor support to between-domain (face name) associative recognition for which optimal performance required a major recollection contribution. These findings suggest that familiarity can support associative recognition memory, particularly for within-domain associations, and contrast with the widely held view that associative recognition depends largely on recollection. [less ▲]

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See detailBioactivity of essential oils from leaves and bark of Laurelia sempervirens and Drimys winteri against Acyrthosiphon pisum
Zapata, Nelson; Lognay, Georges ULg; Smagghe, Guy

in Pest Management Science (2010), 66

BACKGROUND: The pea aphid, Acyrthosiphon pisum (Harris), is a cosmopolitan pest that attacks a wide range of legume crops and vectors important plant virus diseases. In this project, essential oils from ... [more ▼]

BACKGROUND: The pea aphid, Acyrthosiphon pisum (Harris), is a cosmopolitan pest that attacks a wide range of legume crops and vectors important plant virus diseases. In this project, essential oils from the leaf (L) and bark (B) of Laurelia sempervirens (Ruiz& Pav ´ on) Tul. (L) and Drimys winteri JR Forster& GForster (D) were extracted, and their deterrent and insecticidal activities were tested under laboratory conditions. [less ▲]

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See detailArtificially generating sediment incipient motion in natural conditions
Gob, Frédéric ULg; Houbrechts, Geoffrey ULg; Linares Carreté, Alba et al

Poster (2010)

Incipient motion thresholds for gravel bed rivers are studied in flumes and natural rivers. Flume studies allow variables such as channel slope, water velocity, water depth, sediment size and sediment ... [more ▼]

Incipient motion thresholds for gravel bed rivers are studied in flumes and natural rivers. Flume studies allow variables such as channel slope, water velocity, water depth, sediment size and sediment composition to be controlled. Meanwhile, in the field, the incipient motion of particles is studied in natural conditions allowing the structure of the bed and the flood characteristics to be considered. Though much less developed, an intermediate possibility also exists. By artificially accelerating near bottom velocity of the water flow in a small portion of the bed, it is possible to initiate sediment transport. This allows sediment incipient motion to be observed in natural conditions while controlling the water velocities. The Cemagref (HHLY) has developed a device which confines water flow in a small tunnel on the bottom of the riverbed. It was developed in order to create a boundary layer similar to the one generated by natural flow. Water is injected into a filter which smoothes the flow before it enters a Plexiglas tunnel where sediment motion is observed. The flow is accelerated by two large pumps that allow flow velocities of up to 2.5 m/s in a small area 40 cm long, 20 cm wide and 12 cm high. As the water flow is confined, large scale turbulence similar to that occurring in natural rivers cannot be reproduced using the device. The velocity profile in the tunnel is stable and in equilibrium with the riverbed. Sediment motion was observed using this device on three Belgian gravel bed rivers (3.5 cm <D50<8 cm). The incipient critical velocities measured were coherent in the three rivers sampled, ranging between 1.3 m/s and 1.7 m/s. A progressive increase in velocity in the tunnel permitted size selective entrainment to be observed. Analysis of the particle entrainment schemes and associated velocities allowed the role played by the armoured layer and the Di/D50 ratio to be more fully understood. Critical velocities measured using the device were also compared to critical velocities observed in natural conditions, determined during several pebble tracing campaigns. This revealed that incipient motion velocities of the largest particles recorded in artificial conditions were systematically larger than those observed in natural conditions. This demonstrates the roles played by large scale turbulence and the vertical component of the flow velocity in single particle entrainment. Due to its inherent characteristics, both of these flow components are weak in the artificial conditions generated by the device. In conclusion, our study demonstrates that this type of device is a useful tool in observing and studying incipient motion processes and, in particular, the role played by the bed structure (armouring, protrusion, etc.). However, some improvements are still required in order to more accurately measure critical velocities, allowing critical discharges to be determined. [less ▲]

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See detailLa vignette diagnostique de l'etudiant: apprentissage au raisonnement diagnostique.
Moonen, Gustave ULg; Scheen, André ULg

in Revue Médicale de Liège (2010), 65(1), 46-8

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See detailPhenomenology of racing and crowded thoughts in mood disorders: a theoretical reappraisal.
Piguet, Camille; Dayer, Alexandre; Kosel, Markus et al

in Journal of Affective Disorders (2010), 121(3), 189-98

BACKGROUND: Racing thoughts is a frequent symptom in mood disorders, particularly mixed depressive states. This paper aims to summarize our current knowledge about its phenomenology and frequency in the ... [more ▼]

BACKGROUND: Racing thoughts is a frequent symptom in mood disorders, particularly mixed depressive states. This paper aims to summarize our current knowledge about its phenomenology and frequency in the spectrum of mood disorders, and to offer a new theoretical framework. METHODS: We made a selective review of original and review papers in Medline and PsychInfo database using the keywords "racing thoughts", "crowded thoughts" and "depressive mixed state" in conjunction with "mood disorders". RESULTS: In the context of a hypomanic state, "racing thoughts" may appear as a result from an excessive production of thoughts, moving quickly from one to the other, and generating a sense of fluidity and pleasantness. In the context of depression, "racing thoughts" are phenomenologically different and better described as "crowded thoughts": they are not only characterized by too many thoughts occurring at the same time in the field of consciousness, but perceived as unpleasant and induce the feeling that ideas are difficult to catch. DISCUSSION AND CLINICAL RELEVANCE: We suggest that crowded thoughts might result from the mixture of a hypomanic component, with an accelerated production of new thoughts (constituting the main source of this symptom in hypomania), and a depressive component, with a deficit of inhibition of previous thoughts (hence making thoughts crowded rather than truly racing). This distinction could help better identify crowded thoughts, and consequently depressive mixed states, which has important implications for therapeutic management. It might also help to further disentangle the psychobiological processes which contribute to the complexity of mood disorders. [less ▲]

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See detailMohsin Hamid blanchit le fondamentalisme
Munos, Delphine ULg

Article for general public (2010)

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