Publications ORBi OA
Bookmark and Share    
Full Text
Peer Reviewed
See detailNouvelles directives americaines et europeennes en 2003 pour la prise en charge de l'hypertension arterielle
Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (2003), 58(9), 563-571

New American and European guidelines have been released in 2003, the purpose of which is to improve the management of arterial hypertension. The decision to treat high blood pressure now mainly relies on ... [more ▼]

New American and European guidelines have been released in 2003, the purpose of which is to improve the management of arterial hypertension. The decision to treat high blood pressure now mainly relies on the individual cardiovascular risk rather than on the sole blood pressure level. Thus, antihypertensive drugs could be proposed even to normotensive individuals, provided they have a high cardiovascular risk (> 20% at 10 years). On the other hand, grade 1 or 2 hypertensive patients, if their baseline cardiovascular risk is low, will be prescribed antihypertensive drugs only after 3 to 6 months of follow-up. In all cases, individualized non pharmacological means must always be proposed and their use stimulated. The target blood pressure under treatment will be < 140/90 mmHg when the cardiovascular risk is low or moderate, but < 130/80 mmHg when high risk exists. To reach this target, a drug combination is very often necessary, and it frequently includes a low dose of diuretic. To-day, the option of using a low dose biotherapy as an alternative to monotherapy is even proposed as first step antihypertensive treatment. After initiation of treatment, the patient must be regularly followed up and stimulated to decrease his cardiovascular risk to the lowest possible level, following an inclusive approach. [less ▲]

Detailed reference viewed: 202 (5 ULg)
Full Text
Peer Reviewed
See detailPotentiation of tumor necrosis factor-induced NF-kappa B activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I kappa B alpha
Adam, Emmanuelle; Quivy, Vincent; Bex, Françoise et al

in Molecular and Cellular Biology (2003), 23(17), 6200-6209

Previous studies have implicated acetylases and deacetylases in regulating the transcriptional activity of NF-kappaB. Here, we show that inhibitors of deacetylases such as trichostatin A (TSA) and sodium ... [more ▼]

Previous studies have implicated acetylases and deacetylases in regulating the transcriptional activity of NF-kappaB. Here, we show that inhibitors of deacetylases such as trichostatin A (TSA) and sodium butyrate (NaBut) potentiated TNF-induced expression of several natural NF-kappaB-driven promoters. This transcriptional synergism observed between TNF and TSA (or NaBut) required intact kappaB sites in all promoters tested and was biologically relevant as demonstrated by RNase protection on two instances of endogenous NF-kappaB-regulated gene transcription. Importantly, TSA prolonged both TNF-induced DNA-binding activity and the presence of NF-kappaKB in the nucleus. We showed that the p65 subunit of NF-kappaB was acetylated in vivo. However, this acetylation was weak, suggesting that other mechanisms could be implicated in the potentiated binding and transactivation activities of NF-kappaB after TNF plus TSA versus TNF treatment. Western blot and immunofluorescence confocal microscopy experiments revealed a delay in the cytoplasmic reappearance of the IkappaBalpha inhibitor that correlated temporally with the prolonged intranuclear binding and presence of NF-kappaB. This delay was due neither to a defect in IkappaBalpha mRNA production nor to a nuclear retention of IkappaBalpha but was rather due to a persistent proteasome-mediated degradation of IkappaBalpha. A prolongation of IkappaB kinase activity could explain, at least partially, the delayed IkappaBalpha cytoplasmic reappearance observed in presence of TNF plus TSA. [less ▲]

Detailed reference viewed: 39 (5 ULg)
Full Text
Peer Reviewed
See detailWR bubbles and HeII emission
Nazé, Yaël ULg; Rauw, Grégor ULg; Manfroid, Jean ULg et al

in Astronomy and Astrophysics (2003), 408(1), 171-186

We present the very first high quality images of the He II lambda4686 emission in three high excitation nebulae of the Magellanic Clouds. A fourth high excitation nebula, situated around the WR star BAT99 ... [more ▼]

We present the very first high quality images of the He II lambda4686 emission in three high excitation nebulae of the Magellanic Clouds. A fourth high excitation nebula, situated around the WR star BAT99-2, was analysed in a previous letter. Using VLT FORS data, we investigate the morphology of the ring nebulae around the early-type WN stars BAT99-49 [less ▲]

Detailed reference viewed: 18 (2 ULg)
Full Text
Peer Reviewed
See detailHurricane Simulation on Power Transmission Line
Lilien, Jean-Louis ULg; Snegovski, Dmitri; Capelle, Thierry ULg

in Proceedings of the 5th International Conference on Cable Dynamics (2003, September)

The hurricane winds are characterized by high speeds, at which the « drag crisis » regime of flow around cable is achievable. That is why, in the calculation of the wind-induced movement of the overhead ... [more ▼]

The hurricane winds are characterized by high speeds, at which the « drag crisis » regime of flow around cable is achievable. That is why, in the calculation of the wind-induced movement of the overhead transmission line during hurricane, it is important to represent the cable aerodynamic drag as Reynolds-dependent. In order to assess the behaviour and fatigue resistance of the transmission line conductor under hurricane conditions, the Reynolds-dependent drag coefficient was introduced in the SAMCEF Mecano finite-element software. To represent the hurricane wind loading, the turbulent, spatially non-uniform wind model was used. Results of comparative study of the smooth cable AERO-Z and the classical multistrand cable, including the percentage of load reduction offered to supporting structure, are presented. [less ▲]

Detailed reference viewed: 99 (2 ULg)
Full Text
Peer Reviewed
See detailIdentity and expression memory for happy and angry faces in social anxiety
D'Argembeau, Arnaud ULg; Van der Linden, Martial ULg; Etienne, Anne-Marie ULg et al

in Acta Psychologica (2003), 114(1), 1-15

We examined the influence of social anxiety on memory for both identity and emotional expressions of unfamiliar faces. Participants high and low in social anxiety were presented with happy and angry faces ... [more ▼]

We examined the influence of social anxiety on memory for both identity and emotional expressions of unfamiliar faces. Participants high and low in social anxiety were presented with happy and angry faces and were later asked to recognise the same faces displaying a neutral expression. They also had to remember what the initial expressions of the faces had been. Remember/know/guess judgements were asked both for identity and expression memory. For participants low in social anxiety, both identity and expression memory were more often associated with "remember" responses when the faces were previously seen with a happy rather than an angry expression. In contrast, the initial expression of the faces did not affect either identity or expression memory for participants high in social anxiety. We interpreted these findings by arguing that most people tend to preferentially elaborate positive rather than negative social stimuli that are important to the self and that this tendency may be reduced in high socially anxious individuals because of the negative meaning they tend to ascribe to positive social information. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]

Detailed reference viewed: 67 (7 ULg)
Full Text
See detailLe développement foetal
Battisti, Oreste ULg

Learning material (2003)

Ce film montre le dévelopement de l'embryon et du foetus humains à l'usage des obstétriciens, sage-femmes et assistants en pédiatrie.

Detailed reference viewed: 39 (11 ULg)
Full Text
Peer Reviewed
See detailThe antiangiogenic factor 16K human prolactin induces caspase-dependent apoptosis by a mechanism that requires activation of nuclear factor-kappa B
Tabruyn, Sébastien ULg; Sorlet, C. M.; Rentier-Delrue, Françoise ULg et al

in Molecular Endocrinology (2003), 17(9), 1815-1823

We have previously shown that the 16-kDa N-terminal fragment of human prolactin (16K hPRL) has antiangiogenic properties, including the ability to induce apoptosis in vascular endothelial cells. Here, we ... [more ▼]

We have previously shown that the 16-kDa N-terminal fragment of human prolactin (16K hPRL) has antiangiogenic properties, including the ability to induce apoptosis in vascular endothelial cells. Here, we examined whether the nuclear factor-kappaB (NF-kappaB) signaling pathway was involved in mediating the apoptotic action of 16K hPRL in bovine adrenal cortex capillary endothelial cells. In a dose-dependent manner, treatment with 16K hPRL induced inhibitor kappaB-alpha degradation permitting translocation of NF-kappaB to the nucleus and reporter gene activation. Inhibition of NF-kappaB activation by overexpression of a nondegradable inhibitor kappaB-alpha mutant or treatment with NF-kappaB inhibitors blocked 16K hPRL-induced apoptosis. Treatment with 16K hPRL activated the initiator caspases-8 and -9 and the effector caspase-3, all of which were essential for stimulation of DNA fragmentation. This activation of the caspase cascade by 16K hPRL was also NF-kappaB dependent. These findings support the conclusion that NF-kappaB signaling plays a central role in 16K hPRL-induced apoptosis in vascular endothelial cells. [less ▲]

Detailed reference viewed: 19 (6 ULg)
Full Text
See detailReconstruire la ville sur la ville - Recyclage des espaces dégradés
Govearts, Pierre; Timmermans, Anne; Vanloquerena, Tanguy et al

Report (2003)

Detailed reference viewed: 28 (4 ULg)
Full Text
Peer Reviewed
See detailPlace du traitement substitutif de la menopause 1 an apres la publication des resultats de l'etude WHI (Women's Health Initiative)
Pintiaux, Axelle ULg; Van den Brule, F.; Foidart, Jean-Michel ULg et al

in Revue Médicale de Liège (2003), 58(9), 572-5

The currently reported data concerning the large WHI randomized controlled trial compare the impact of continuous combined conjugated estrogens + medroxyprogesterone acetate vs placebo in postmenopausal ... [more ▼]

The currently reported data concerning the large WHI randomized controlled trial compare the impact of continuous combined conjugated estrogens + medroxyprogesterone acetate vs placebo in postmenopausal women. These results appear largely pessimistic. After 5.2 years of hormone replacement, an excess of coronary heart disease, cerebrovascular disease, venous thromboembolism, breast cancer incidence and extension, mild cognitive impairment and dementia is recorded. By contrast, osteoporotic fracture risk and colorectal cancer are decreased during hormone replacement. Accordingly, this hormonal treatment can no longer be recommended on a long term basis, except after extensive risk-benefit balance evaluation. It should no longer be prescribed for prevention of chronic diseases. It remains indicated during 4-5 years for relief of vasomotor symptoms, genital atrophy and, potentially, for some aspects of quality of life. HRT should probably be prescribed in minimal-effective dosages; new regimens, routes of administration, new compounds and associations should be envisaged in order to avoid cardiovascular or breast problems. However these new approaches ask for thorough validation studies. [less ▲]

Detailed reference viewed: 90 (0 ULg)
Full Text
See detailPatrimoine naturel
Feltz, Claude ULg; Melin, Eric ULg

Report (2003)

Detailed reference viewed: 13 (1 ULg)
Full Text
See detailPatrimoine paysager
Feltz, Claude ULg; Melin, Eric ULg

Report (2003)

Detailed reference viewed: 12 (1 ULg)
Full Text
Peer Reviewed
See detailLiver transplantation for metastatic colon adenocarcinoma: report of a case with 10 years of follow-up without recurrence
Honore, Charles ULg; Detry, Olivier ULg; De Roover, Arnaud ULg et al

in Transplant International (2003), 16(9), 692-693

Because of dismal mid-term and long-term results, secondary liver cancer is considered an absolute contra-indication to cadaveric liver transplantation, with the relative exception of metastases of ... [more ▼]

Because of dismal mid-term and long-term results, secondary liver cancer is considered an absolute contra-indication to cadaveric liver transplantation, with the relative exception of metastases of symptomatic neuro-endocrine cancers. The authors present in this report the case of a patient who has been enjoying 10 years of cancer-free survival after liver transplantation as rescue therapy for acute liver failure after liver resection for isolated hepatic metastasis of colon adenocarcinoma. This case shows that in some highly selected cases, liver transplantation may be curative in patients with liver metastases of colon carcinoma. [less ▲]

Detailed reference viewed: 83 (8 ULg)
Full Text
Peer Reviewed
See detailY a-t-il une place d'emblée pour une bithérapie faiblement dosée dans le traitement de l'hypertension artérielle essentielle?
Krzesinski, Jean-Marie ULg; Rorive, Marcelle ULg

in Médecine et Hygiène (2003), 61

If the treatment of hypertension is very useful to decrease the cardiovascular risk, the way to get the normalisation of high blood pressure is difficult in spite of many families of antihypertensive ... [more ▼]

If the treatment of hypertension is very useful to decrease the cardiovascular risk, the way to get the normalisation of high blood pressure is difficult in spite of many families of antihypertensive agents with different mechanisms of action. To reach such objective, association of different drugs are most often required. But, the european guidelines for the management of hypertension have just been released and proposed the possibility to begin very-low-dose combination therapy first-line. These associations offer immediate higher efficacy, excellent tolerance and low cost. [less ▲]

Detailed reference viewed: 22 (1 ULg)
Full Text
See detailPiloter le futur ...
Van Caillie, Didier ULg

Article for general public (2003)

This chronicle insists on the importance of monitoring the future in firms, independently from their size, and on the interest for using performance management tools such as "Balanced Scorecards" to ... [more ▼]

This chronicle insists on the importance of monitoring the future in firms, independently from their size, and on the interest for using performance management tools such as "Balanced Scorecards" to monitor uncertain environments. [less ▲]

Detailed reference viewed: 30 (4 ULg)
Full Text
Peer Reviewed
See detailMagnetically controlled ballistic deposition. A model of polydisperse granular packing
Trojan, K.; Ausloos, Marcel ULg

in Physica A-Statistical Mechanics and its Applications (2003), 326(3-4), 492-510

The flow and deposition of polydisperse granular materials is simulated through the magnetic diffusion limited aggregation (MDLA) model. The random walk undergone by an entity in the MDLA model is ... [more ▼]

The flow and deposition of polydisperse granular materials is simulated through the magnetic diffusion limited aggregation (MDLA) model. The random walk undergone by an entity in the MDLA model is modified such that the trajectories are ballistic in nature, leading to a magnetically controlled ballistic deposition (MBD) model. This allows to obtain important ingredients about a difficult problem that of the nonequilibrium segregation of polydisperse sandpiles and heterogeneous adsorption of a binary distribution of particles which can interact with each other and with an external field. Our detailed results from many simulations of MBD clusters on a two-dimensional triangular lattice above a flat surface in a vertical finite size box for binary systems indicates intriguing variations of the density, "magnetization", types of clusters and fractal dimensions. We derive the field and grain interaction-dependent susceptibility and compressibility. We deduce a completely new phase diagram for binary granular piles and discuss its complexity inherent to different grain competition and cluster growth probabilities. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]

Detailed reference viewed: 18 (0 ULg)
Full Text
See detailBulletin agrométéorologique - Juillet 2003
Tychon, Bernard ULg; Ozer, Pierre ULg; Eerens, H. et al

in Bulletin Agrométéorologique (2003)

Detailed reference viewed: 4 (1 ULg)
Full Text
Peer Reviewed
See detailA camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme
Dumoulin, Mireille ULg; Last, A. M.; Desmyter, A. et al

in Nature (2003), 424(6950), 783-788

Amyloid diseases are characterized by an aberrant assembly of a specific protein or protein fragment into fibrils and plaques that are deposited in various organs and tissues(1-3), often with serious ... [more ▼]

Amyloid diseases are characterized by an aberrant assembly of a specific protein or protein fragment into fibrils and plaques that are deposited in various organs and tissues(1-3), often with serious pathological consequences. Non-neuropathic systemic amyloidosis (4-6) is associated with single point mutations in the gene coding for human lysozyme. Here we report that a single-domain fragment of a camelid antibody(7-9) raised against wild-type human lysozyme inhibits the in vitro aggregation of its amyloidogenic variant, D67H. Our structural studies reveal that the epitope includes neither the site of mutation nor most residues in the region of the protein structure that is destabilized by the mutation. Instead, the binding of the antibody fragment achieves its effect by restoring the structural cooperativity characteristic of the wild-type protein. This appears to occur at least in part through the transmission of long-range conformational effects to the interface between the two structural domains of the protein. Thus, reducing the ability of an amyloidogenic protein to form partly unfolded species can be an effective method of preventing its aggregation, suggesting approaches to the rational design of therapeutic agents directed against protein deposition diseases. [less ▲]

Detailed reference viewed: 108 (11 ULg)