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See detailAlimenter le lien entre consommateurs, éleveurs et animaux.
Lamine Claire; Stassart, Pierre M ULg; Bartiaux, Nicole et al

Report (2006)

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See detailAssessment of the processes controlling the seasonal variations of dissolved inorganic carbon in the North Sea
Bozec, Y.; Thomas, H.; Schiettecatte, L. S. et al

in Limnology & Oceanography (2006), 51(6), 27462762

We used a seasonal North Sea data set comprising dissolved inorganic carbon (DIC), partial pressure of CO2 (pCO2), and inorganic nutrients to assess the abiotic and biological processes governing the ... [more ▼]

We used a seasonal North Sea data set comprising dissolved inorganic carbon (DIC), partial pressure of CO2 (pCO2), and inorganic nutrients to assess the abiotic and biological processes governing the monthly variations of DIC. During winter, advection and air–sea exchange of CO2 control and increase the DIC content in the surface and deeper layers of the northern and central North Sea, with the atmosphere supplying CO2 on the order of 0.2 mol C m22 month21 to these areas. From February to July, net community production (NCP) controls the seasonal variations of DIC in the surface waters of the entire North Sea, with a net uptake ranging from 0.5 to 1.4 mol C m22 month21. During the August–December period, NCP controls the seasonal variations of DIC in the southern North Sea, with a net release ranging from 0.5 to 0.8 mol C m22 month21. Similarly, during the April–August period in the deeper layer of the northern North Sea, the NCP was the main factor controlling DIC concentrations, with a net release ranging from 0.5 to 5.5 mol C m22 month21. In the surface layer of the North Sea, NCP on the basis of DIC was 4.3 6 0.4 mol C m22 yr21, whereas, NCP on the basis of nitrate was 1.6 6 0.2 mol C m22 yr21. Under nutrient-depleted conditions, preferential recycling (extracellular) of nutrients and intracellular mechanisms occurred and were responsible for the non-Redfield uptake of DIC versus nitrate and phosphate. [less ▲]

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See detailMedecin de famille et intoxication au monoxyde de carbone
Burette, Philippe ULg; Bouüaert, Corine ULg; Vanmeerbeek, Marc ULg et al

in Revue Médicale de Liège (2006), 61(5-6, May-Jun), 285-90

Carbon monoxide poisoning is not easily identifiable. It is the first cause of death by accidental poisoning in Europe. The family practitioner, who has not been made aware of this problem, incurs the ... [more ▼]

Carbon monoxide poisoning is not easily identifiable. It is the first cause of death by accidental poisoning in Europe. The family practitioner, who has not been made aware of this problem, incurs the risk of diagnostic indecision or of involuntary personal poisoning. Since symptomatology is non specific, the general practitioner answering housecalls is sometimes confronted with an urgent medical problem linked to the complications of this intoxication (coronary, neurological problems...), without having ways of documenting its origin of the poisoning or any means to protect himself. Through direct contact with his patients' environment, the family practitioner, being made sensitive to this problem, can certainly contribute to care and aftercare of the patient suffering from carbon monoxide poisoning, but also to the prevention of this public health problem often called "the silent killer". [less ▲]

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See detailOrganic carbon metabolism and carbonate dynamics in a Mediterranean seagrass (Posidonia oceanica) meadow
Barrón, Cristina; Duarte, Carlos M.; Frankignoulle, Michel et al

in Estuaries and Coasts (2006), 29(3), 417-426

in a Posidonia oceanica meadow and unvegetated sediments of Magalluf Bay (Mallorca Island, Spain) to determine gross primary production (GPP), community respiration (R), and net community production (NCP ... [more ▼]

in a Posidonia oceanica meadow and unvegetated sediments of Magalluf Bay (Mallorca Island, Spain) to determine gross primary production (GPP), community respiration (R), and net community production (NCP). From June 2001 to October 2002, we also measured fluxes of dissolved inorganic carbon (DIC) and total alkalinity (TAlk). The yearly integrated metabolic rates based on DO changes show that the P. oceanica communities are net autotrophic while the metabolic rates in the unvegetated benthic communities are nearly balanced. Higher calcium carbonate (CaCO3) cycling, both in terms of production and dissolution, was observed in P. oceanica communities than in unvegetated benthic communities. In the P. oceanica meadow, the annual release of CO2 from net CaCO3 production corresponds to almost half of the CO2 uptake by NCP based on DIC incubations. In unvegetated benthic communities, the annual uptake of CO2 from net CaCO3 dissolution almost fully compensates the CO2 release by NCP based on DIC incubations. CaCO3 dynamics is potentially a major factor in CO2 benthic fluxes in seagrass and carbonate-rich temperate coastal ecosystems. [less ▲]

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See detailSpeech discrimination and intelligibility: outcome of deaf children fitted with hearing aids or cochlear implants.
Lejeune, Brigitte ULg; Demanez, Laurent

in B-ENT (2006), 2(2), 63-68

We retrospectively studied outcome of a sample of 36 congenitally deaf children who were fitted with either a conventional hearing aid or a cochlear implant and who received many years of audio-phonatory ... [more ▼]

We retrospectively studied outcome of a sample of 36 congenitally deaf children who were fitted with either a conventional hearing aid or a cochlear implant and who received many years of audio-phonatory training.To rate auditory capacity and speech intelligibility, we used commonly used metrics: CAP and SIR. At the end of the 5-Years period, CAP and SIR scores of cochlear implant children are significantly higher than those of conventional hearing aid children. This study is one of few that evaluates outcome of conventional hearing aid and cochlear implant fitting with age matched congenitally deaf children anno 2000. [less ▲]

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See detailLe risque de préjudice grave difficilement réparable en matière de nomination ou de promotion dans la fonction publique
Donnay, Luc ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2006), (1), 24-42

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See detailInfluence of the matrix on analyte fragmentation in atmospheric pressure MALDI
Schulz, Eric; Karas, Michael; Rosu, Frédéric ULg et al

in Journal of the American Society for Mass Spectrometry (2006), 17(7), 1005-1013

In this paper, we report the measurement of the degree of analyte fragmentation in AP-MALDI as a function of the matrix and of the laser fluence. The analytes include p-OCH3-benzylpyridinium, three ... [more ▼]

In this paper, we report the measurement of the degree of analyte fragmentation in AP-MALDI as a function of the matrix and of the laser fluence. The analytes include p-OCH3-benzylpyridinium, three peptides containing the sequence EEPP (which cleave very efficiently at the E-P site), and three deoxynucleosides (dA, dG, and dC), which lose the neutral sugar to give the protonated base. We found that the matrix hardness/softness was consistent when comparing the analytes, with a consensus ranking from hardest to softest: CHCA >> DHB > SA approximate to THAP > ATT > HPA. However, the exact ranking can be fluence-dependent, for example between ATT and HPA. Our goal here was to provide the scientific community with a detailed dataset that can be used to compare with theoretical predictions. We tried to correlate the consensus ranking with different matrix properties: sublimation or decomposition temperature (determined using thermogravimetry), analyte initial velocity, and matrix proton affinity. The best correlation was found with the matrix proton affinity. [less ▲]

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See detailTransfusions after nonmyeloablative or reduced-intensity conditioning regimens.
Baron, Frédéric ULg; Vanstraelen, Gaëtan; Beguin, Yves ULg

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (2006), 20(12), 2081-6

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See detailIncreased iron absorption during autologous blood donation supported by recombinant human erythropoietin therapy.
Bovy, Christophe ULg; Baudoux, Etienne ULg; Salmon, Jean ULg et al

in Transfusion (2006), 46(9), 1616-23

BACKGROUND: Recombinant human erythropoietin (rHuEPO) therapy improves the success of autologous blood (AB) donation programs before elective surgery. The aim of this study was to evaluate iron absorption ... [more ▼]

BACKGROUND: Recombinant human erythropoietin (rHuEPO) therapy improves the success of autologous blood (AB) donation programs before elective surgery. The aim of this study was to evaluate iron absorption during an AB donation program with or without rHuEPO. STUDY DESIGN AND METHODS: Thirty-two patients were randomly assigned among placebo (Group 1) or 300 (Group 2) or 600 UI per kg rHuEPO (Group 3) on the first, second, and third donation visits. All patients also received daily oral iron (200 mg Fe(+)). RESULTS: The number of units collected in Group 3 was higher than in Group 1 (4.6 +/- 0.5 vs. 3.6 +/- 0.8 units; p < 0.01). Red blood cell (RBC) production increased in a rHuEPO dose-dependent manner. With rHuEPO, the RBC volume collected per unit presented a lower decrease with number of donated units than with placebo and was similar to that of homologous blood units. Storage iron did not influence the number of units collected, whereas circulating mobilizable iron was the limiting factor. Oral iron absorption increased in a rHuEPO dose-dependent manner (12-fold with 600 UI/kg rHuEPO) and was proportional to erythropoietic activity. CONCLUSION: rHuEPO does not only improve the number of AB units collected but also their quality. Storage iron cannot meet marrow iron requirements, but rHuEPO strongly increased oral iron absorption in a dose-dependent fashion through stimulation of erythropoietic activity. [less ▲]

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See detailIron and the anaemia of chronic disease: a review and strategic recommendations.
Cavill, Ivor; Auerbach, Michael; Bailie, George R et al

in Current Medical Research & Opinion (2006), 22(4), 731-7

BACKGROUND: The incidence of anaemia is high in many chronic conditions, yet it often receives little attention. SCOPE/METHODS: A panel of international experts with experience in haematology, nephrology ... [more ▼]

BACKGROUND: The incidence of anaemia is high in many chronic conditions, yet it often receives little attention. SCOPE/METHODS: A panel of international experts with experience in haematology, nephrology, oncology, rheumatology and pharmacy was convened to prepare strategic guidelines. A focused literature search was conducted after key issues had been identified. A series of recommendations was agreed, backed, wherever possible, by published evidence which is included in the annotations. RECOMMENDATIONS: Anaemia is a critical issue for patients with chronic diseases. Healthcare professionals need to recognise that anaemia is a frequent companion of cancer and chronic conditions such as rheumatoid arthritis and heart failure. It reduces patients' quality of life and can increase morbidity and mortality. Anaemia should be considered as a disordered process in which the rate of red cell production fails to match the rate of destruction which leads eventually to a reduction in haemoglobin concentration; this process is common to all chronic anaemias. The aim of anaemia management should be to restore patient functionality and quality of life by restoring effective red cell production. Blood transfusion can elevate haemoglobin concentration in the short term but does nothing to address the underlying disorder; red cell transfusion is, therefore, not an appropriate treatment for chronic anaemia. Patients with anaemia of chronic disease may benefit from iron therapy and/or erythropoiesis stimulating agents (ESAs). Intravenous iron should be considered since this can be given safely to patients with chronic diseases while intramuscular iron causes unacceptable adverse effects and oral iron has limited efficacy in chronic anaemia. CONCLUSION: The management of anaemia calls for the development of a specialist service together with education of all healthcare professionals and transfer of skills from areas of good practice. Improvement in the management of anaemia requires a fundamental change of attitude from healthcare professionals. [less ▲]

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See detailPegfilgrastim compared with Filgrastim after autologous hematopoietic peripheral blood stem cell transplantation.
Vanstraelen, Gaetan; Frere, Pascale ULg; Ngirabacu, Marie-Christine et al

in Experimental hematology (2006), 34(3), 382-8

In order to assess the effect of Pegfilgrastim on the duration of neutropenia and clinical outcome of patients after autologous peripheral blood stem cell (PBSC) transplantation, we compared 20 ... [more ▼]

In order to assess the effect of Pegfilgrastim on the duration of neutropenia and clinical outcome of patients after autologous peripheral blood stem cell (PBSC) transplantation, we compared 20 consecutive patients with lymphoma or multiple myeloma receiving a single 6-mg dose of Pegfilgrastim on day 1 posttransplant to an historical control group of 60 patients receiving daily Filgrastim 5 microg/kg starting on day 1 posttransplant. The duration of neutropenia was similar in the Pegfilgrastim group compared with the control group. There were no differences in time to neutrophil, erythroid, or platelet engraftment nor in the incidence of fever and infections. The duration of antibiotic therapy, transfusion support, and time to hospital discharge were similar in the two groups. However, after initial hematopoietic reconstitution, we observed significantly higher values of lymphocytes (e.g., 1,660+/-1,000 versus 970+/-460 on day 80, p=0.0002), neutrophils (e.g., 3,880+/-2,030 versus 2,420+/-1,500 on day 25, p=0.0004), reticulocytes (e.g., 148,160+/-90,590 versus 87,140+/-65,920 on day 25, p<0.0001), and platelets (e.g., 210,700+/-116,090 versus 150,240+/-58,230 on day 55, p=0.0052) up to day 100 in the Pegfilgrastim group compared with the Filgrastim group. These observations had no impact on clinical outcome of the patients after day 30 due to the low incidence of infectious events after engraftment in autologous PBSC transplantation. We conclude that the effect of Pegfilgrastim administrated on day 1 posttransplant is comparable to that of daily Filgrastim on initial hematopoietic reconstitution. The possibly superior effect of Pegfilgrastim on cell counts we observed after initial engraftment should be further tested in a prospective randomized trial. [less ▲]

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See detailInfections after allogeneic hematopoietic stem cell transplantation with a nonmyeloablative conditioning regimen.
Frere, Pascale ULg; Baron, Frédéric ULg; Bonnet, Christophe ULg et al

in Bone Marrow Transplantation (2006), 37(4), 411-8

Hematopoietic cell transplantation (HCT) following nonmyeloablative conditioning (NMSCT) may be associated with a reduced risk of infection compared to standard allogeneic HCT. We retrospectively analyzed ... [more ▼]

Hematopoietic cell transplantation (HCT) following nonmyeloablative conditioning (NMSCT) may be associated with a reduced risk of infection compared to standard allogeneic HCT. We retrospectively analyzed incidence and risk factors of infection in 62 patients undergoing NMSCT with low-dose TBI +/- fludarabine and postgrafting CsA and MMF. The proportion of patients with any infection was 77%, but the majority of infectious events occurred beyond day 30. Donor other than sibling, older age, early disease and male gender were significant risk factors. The incidence of bacteremia was 55% at 1 year and the number of bacteremic episodes was 0.9 per patient (0.08 before day 30). The risk of bacteremia increased with older age and the use of a donor other than an HLA-identical sibling, but not with neutropenia. The incidence of infections other than bacteremia correlated with the use of corticosteroids. The risk of CMV infection increased with high-risk CMV serology, and risk of CMV disease with high-risk CMV serology, older age, first transplantation and a diagnosis of lymphoma. In conclusion, after NMSCT, infections are not frequent in the first 30 days post transplant but careful long-term monitoring is necessary thereafter. [less ▲]

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See detailRecombinant human erythropoietin therapy after allogeneic hematopoietic cell transplantation with a nonmyeloablative conditioning regimen: low donor chimerism predicts for poor response.
Vanstraelen, Gaëtan; Baron, Frédéric ULg; Willems, Evelyne ULg et al

in Experimental hematology (2006), 34(7), 841-50

PURPOSE: After allogeneic hematopoietic stem cell transplantation with nonmyeloablative conditioning (NMHCT), many patients experience prolonged anemia and require red blood cell (RBC) transfusions. We ... [more ▼]

PURPOSE: After allogeneic hematopoietic stem cell transplantation with nonmyeloablative conditioning (NMHCT), many patients experience prolonged anemia and require red blood cell (RBC) transfusions. We enrolled 60 consecutive patients undergoing NMHCT in a phase II trial to determine the optimal utilization of recombinant human erythropoietin (rHuEPO) therapy in this setting. PATIENTS AND METHODS: The first 14 NMHCT recipients did not receive rHuEPO (control group). Nineteen patients were scheduled to start rHuEPO on day 0 (EPO group 2) and 27 patients on day 28 after the transplant (EPO group 1). RHuEPO was administered subcutaneously once weekly at a dose of 500 U/kg/wk with the aim of achieving hemoglobin (Hb) levels of 13 g/dL. The 3 groups were well balanced for major characteristics. RESULTS: During the first month (p < 0.0001) as well as days 30 to 100 (p < 0.0001) and days 100 to 180 (p < 0.0001), Hb values were higher in patients receiving rHuEPO compared to those not receiving it. However, transfusion requirements were significantly decreased only in the first month in EPO group 2 (p = 0.0169). T-cell chimerism above 60% on day 42 was the best predictor of Hb response (p < 0.0001) or Hb correction (p = 0.0217), but myeloid chimerism above 90% also predicted for Hb response (p = 0.0069). Hb response was also decreased in patients receiving CD8-depleted grafts and increased in the few patients not receiving TBI, but only in univariate analysis. CONCLUSIONS: Anemia after NMHCT is sensitive to rHuEPO therapy, but less so than after conventional allogeneic HCT. RHuEPO decreases transfusion requirements only in the first 30 days posttransplant. T-cell chimerism below 60% on day 42 impaired Hb response, suggesting possible inhibition of donor erythropoiesis by residual recipient lymphocytes. A prospective randomized trial should be performed with rHuEPO starting on the day of transplantation to assess its clinical benefit in terms of transfusion requirements and quality of life. [less ▲]

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See detailSur les difficultés d'application du standstill dans la passation des marchés publics
Lewalle, Paul ULg; Donnay, Luc ULg

in Revue de la Faculté de Droit de l'Université de Liège (2006), 1-2

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See detailBoules et autres masses". Prise en charge rationnelle des tumeurs des tissus mous."
Kurth, William ULg; Gillet, Philippe ULg

in Revue Médicale de Liège (2006), 61(11), 763-70

Patients with soft-tissue tumours usually consult for a mass at the level of an extremity or the torso. This article aims to help the general practitioner and the general surgeon in the standardized setup ... [more ▼]

Patients with soft-tissue tumours usually consult for a mass at the level of an extremity or the torso. This article aims to help the general practitioner and the general surgeon in the standardized setup of these tumours. The epidemiology, clinical presentation and evaluation as well as the useful exams to be performed, including biopsy, are developped, in order to obtain rational principles for the diagnostic setup and surgical decision-making. [less ▲]

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See detailEtude clinique du mois. L'etude DREAM: prevention du diabete de type 2 par le ramipiril et/ou la rosiglitazone chez les personnes dysglycemiques sans maladie cardio-vasculaire.
Scheen, André ULg

in Revue Médicale de Liège (2006), 61(10), 728-32

DREAM ("Diabetes Reduction Assessment with ramipril and rosiglitazone Medication") is a double-blind randomised placebo-controlled clinical trial with a 2-by-2 factorial design aiming to study the effects ... [more ▼]

DREAM ("Diabetes Reduction Assessment with ramipril and rosiglitazone Medication") is a double-blind randomised placebo-controlled clinical trial with a 2-by-2 factorial design aiming to study the effects of an ACE inhibitor (ramipril 15 mg/day) and/or a thiazolidinedione (rosiglitazone 8 mg/day) on the development of diabetes or death (primary outcome) and on the regression to normoglycaemia (secondary outcome) in 5269 adults aged 30 years or more with impaired fasting glucose and/or impaired glucose tolerance, and no previous cardiovascular disease. There was no statistical evidence of an interaction between the ramipril and the rosiglitazone arms. After a mean follow up of 3 years, the use of ramipril does not significantly reduce the incidence of diabetes or death but does significantly increase regression to normoglycaemia. In contrast, the treatment with rosiglitazone reduces by almost 60% the incidence of type 2 diabetes and increases the likelihood (+70%) of regression to normoglycaemia. Whether it is a true prevention effect or simply a treatment effect remains to be determined when participants will be retested after a washout period. Cardiovascular event rates were rather low and much the same in all treatment groups, except a higher rate of heart failure in the rosiglitazone group. These results suggest that the routine inhibition of the renin-angiotensin system for the express purpose of preventing diabetes is not indicated in individuals not at high risk for cardiovascular disease and appear to confirm the promises of the glitazone use in the very early stage of the natural history of type 2 diabetes. [less ▲]

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See detailLe syndrome metabolique: physiopathologie et traitement
Scheen, André ULg

in Athérosclérose, athérothrombose (2006)

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See detailNote on singular optima in laminate design problems
Bruyneel, Michael; Duysinx, Pierre ULg

in Structural and Multidisciplinary Optimization (2006), 31(2), 156-159

This paper studies the design of laminates subject to restrictions on the ply strength. The minimum weight design is considered. It is shown that this formulation includes singular optima, which are ... [more ▼]

This paper studies the design of laminates subject to restrictions on the ply strength. The minimum weight design is considered. It is shown that this formulation includes singular optima, which are similar to the ones observed in topology optimization including local stress constraints. In laminate design, these singular optima are linked to the removal of 'zero thickness' plies from the stacking sequence. It is shown how the fiber orientation variables can circumvent the singularity by relaxing the strength constraints related to such vanishing plies. This demonstrates the key role of fiber orientations in the optimization of laminates and the need for their efficient treatment as design variables. [less ▲]

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See detailLe Conseil d'Etat et la connexité
Donnay, Luc ULg

in Journal des Tribunaux (2006), 6234

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