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See detailLe médicament du mois. L'association calcipotriol-dipropionate de bétamethasone (dovobet).
Henry, Frédérique ULg; Flagothier, Caroline ULg; Delvoye, Pierre et al

in Revue Médicale de Liège (2005), 60(11), 893-5

The topical treatment of psoriasis benefits from the alternate use of dermocorticosteroids and vitamin D3 analogues. A new galenic formulation allows to combine them in a single application. Dovobet (LEO ... [more ▼]

The topical treatment of psoriasis benefits from the alternate use of dermocorticosteroids and vitamin D3 analogues. A new galenic formulation allows to combine them in a single application. Dovobet (LEO Pharma) ointment is the association of calcipotriol 50 microg/g with betamethasone dipoprionate 0.5 mg/g. This formulation boosts the therapeutic activity of calcipotriol. It also decreases the irritative inflammatory reaction due to calcipotriol without increasing the atrophogenic risk of the dermocorticoid. [less ▲]

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See detailDe la pomme d'amour au bouquet de la peau humaine ... et si elle exhalait aussi des phéromones?
Xhauflaire, Emmanuelle ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2005), 60(12), 946-8

Skin exhales odours forming a bouquet which seems unique for each individual. The westernised socio-cultural behaviour tends to suppress them and to replace them by perfumes. The existence and the role of ... [more ▼]

Skin exhales odours forming a bouquet which seems unique for each individual. The westernised socio-cultural behaviour tends to suppress them and to replace them by perfumes. The existence and the role of human phaeromones remain unsettled. Physiological and behavioural effects can be modulated by body odours and their putative phaeromones. [less ▲]

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See detailEffets cutanés indésirables du lithium.
Paquet, Philippe ULg; Claessens, Nadine; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2005), 60(11), 885-7

Oral administration of lithium is used as treatment in psychiatry. The drug frequently induces cutaneous side effects corresponding to acneiform or maculo-papular eruptions, psoriasis and folliculitis ... [more ▼]

Oral administration of lithium is used as treatment in psychiatry. The drug frequently induces cutaneous side effects corresponding to acneiform or maculo-papular eruptions, psoriasis and folliculitis. Men are more frequently affected than women. These manifestations are characterized by the accumulation of neutrophils in the skin. Alopecia and classical drug reactions are also possible. Topical applications of lithium used to treat some dermatoses do not induce similar side effects, probably because dosages are much lower. [less ▲]

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See detailAnalytical quantification of the inflammatory cell infiltrate and CD95R expression during treatment of drug-induced toxic epidermal necrolysis.
Paquet, Philippe ULg; Jacob, Eric; Damas, Pierre ULg et al

in Archives of Dermatological Research (2005), 297(6), 266-73

The treatment of drug-induced toxic epidermal necrolysis (TEN) remains unsatisfactory. Intravenous immunoglobulins (IVIg) and intravenous cyclosporin A (CsA) have shown some efficacy in short series of ... [more ▼]

The treatment of drug-induced toxic epidermal necrolysis (TEN) remains unsatisfactory. Intravenous immunoglobulins (IVIg) and intravenous cyclosporin A (CsA) have shown some efficacy in short series of patients. We assessed the effects of IVIg and CsA on TEN lesional and apparently uninvolved skin using standard histology and immunohistochemistry. Cutaneous biopsies were taken from necrotic and clinically uninvolved TEN skin at admission (D1) before any treatment, and after a 5-day treatment (D5). Two IVIg-treated patients (0.75 g/kg/day), two CsA-treated patients (5 mg/kg/day) and two control patients only receiving supportive care were compared. Biopsies were examined by standard histology and immunohistochemistry using antibodies directed to CD68 antigen (macrophages), CD45R0 antigen (activated T lymphocytes), Factor XIIIa (dermal dendrocytes) and the CD95 receptor (apoptosis marker). The different cell densities were evaluated by computerized image analysis. The clinical outcomes with the different treatments were also recorded. There was no obvious difference in the duration of hospitalization in intensive care unit between the three groups but one patient passed away in each of the IVIg- and CsA-groups. At D5, no differences were found between the three groups in the histological and clinical rate of re-epithelialization, and in the evolution of T lymphocyte, macrophage and dendrocyte densities in the epidermis and dermis. However, the expression of the CD95 receptor was similarly and strongly abated at D5 in the epidermis of IVIg- and CsA-treated patients, while it was conversely increased in the two patients under supportive care only. Such a difference was found both in necrotic and uninvolved sites. IVIg and CsA treatments thus appeared to exert no obvious effect on the inflammatory infiltrate, but both abated the expression of the CD95 receptor in the skin of TEN patients. This effect did not seem sufficient to fully reverse the clinical evolution of the disease. It is inferred that IVIg and CsA do not completely abate the TEN process. [less ▲]

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See detailThe Photoabsorption and Photoionization of Halogenated Ethylenes: brominated Derivatives.
Locht, Robert ULg; Leyh, Bernard ULg; Jochims, H.-W. et al

Book published by Berliner Elektronen Speicherring für Synchrotron Strahlung m.b.H - on CD-ROM (2005)

The V-UV photoabsorption spectrum of C2HBrF2, C2BrF3 and C2ClF3 have been measured using synchrotron radiation. The mass spectrometric photoionization of C2HBrF2 is also reported.

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See detailPrescription de l'action publique : le droit transitoire de l'article 24 TPCPP à l'épreuve de la Cour d'arbitrage
Monville, Pierre ULg

in Revue de Droit Pénal et de Criminologie (2005)

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See detailL'haptoglobine, marqueur protéique de l'inflammation aiguë, dans l'espèce bovine
Humblet, Marie-France ULg; Godeau, Jean-Marie ULg

in Annales de Médecine Vétérinaire (2005), 149(1), 20-33

Among acute phase proteins, haptoglobin is considered as the most interesting in cattle. Due to its early and marked increase in acute inflammation, it is useful for the diagnosis and prognosis of acute ... [more ▼]

Among acute phase proteins, haptoglobin is considered as the most interesting in cattle. Due to its early and marked increase in acute inflammation, it is useful for the diagnosis and prognosis of acute inflammation and for the evaluation of treatment. Physiological variations of its serum concentrations can be observed in the days following parturition. From very low or even undetectable concentrations, its serum levels can rise significantly during acute inflammation. Haptoglobin could improve the sanitary control of animals and the identification of pathologies even before clinical signs become apparent. It could also detect subclinical diseases and improve the sanitary control at the slaughterhouse, because haptoglobin has a good combination of specificity and sensitivity in such a context. At the herd scale, it could be used to evaluate the sanitary status in order to allocate it a quality label. [less ▲]

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See detailChronique de droit international privé : le Code de droit international privé
Wautelet, Patrick ULg

in Chronique de droit à l’usage du notariat - vol. XXXXII (2005)

This text gives a general overview of the Code of Private International Law (Act of 16 July 2004, published in the Official Gazette on 27th July 2004), which entered into force on 1st of October 2004. The ... [more ▼]

This text gives a general overview of the Code of Private International Law (Act of 16 July 2004, published in the Official Gazette on 27th July 2004), which entered into force on 1st of October 2004. The text focuses primarily on the aspects of the Code which are useful for notaries, such the law of estate and the law of matrimonial property. The text also gives an overview of the general rules of the Code of Private International law, with specific attention to the innovations (such as the escape clause to be found in Article 19). [less ▲]

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See detailThe art and science of teaching in physcal education and sport. A homage to Maurice Piéron
Carreiro da Costa, Francisco; Cloes, Marc ULg; González Valeiro, Miguel

Book published by Faculdade de Motricidade Humana (2005)

This book is, before all, a sign of recognition and friendship. The content of the book intents to express the main characteristics of Maurice Piéron’s personality: competency, engagement involvement ... [more ▼]

This book is, before all, a sign of recognition and friendship. The content of the book intents to express the main characteristics of Maurice Piéron’s personality: competency, engagement involvement, liability, reliability and an open mind spirit towards different cultures and mentalities. Some texts conceptualise the content of sport pedagogy; others present the state of the art in some lines of research in physical education, sport or physical education teacher education; others offer a critical reflection focused on some scientific alternatives, and, finally, some texts establish links between the knowledge produced by research and its application in practice. [less ▲]

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See detailLe développement durable est-il l'héritier du mouvement pro-environnement ?
Semal, Nathalie ULg

in Esprit critique (2005), 7(1), 100-115

Le développement durable est souvent présenté comme l'aboutissement naturel de la montée des préoccupations environnementales. Il a pourtant constitué un tournant dans l'appréhension des problèmes ... [more ▼]

Le développement durable est souvent présenté comme l'aboutissement naturel de la montée des préoccupations environnementales. Il a pourtant constitué un tournant dans l'appréhension des problèmes environnementaux car il a modifié le débat public autour de cette problématique et a ouvert un espace d'action pour de nouveaux acteurs. Porteur d'une vision conciliatrice entre objectifs économiques et environnementaux, le développement durable s'inscrit dans une approche de l'écologisation comme "modernisation" de la techno-sphère qui se démarque de la pensée écologiste. [less ▲]

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See detailCdc42 downregulates MMP-1 expression by inhibiting the ERK1/2 pathway.
Deroanne, Christophe ULg; Hamelryckx, Delphine; Ho, Thi Thanh Giang ULg et al

in Journal of Cell Science (2005), 118(Pt 6), 1173-83

The small GTPases of the Rho family are key intermediates in cellular signalling triggered by activated cell-adhesion receptors. In this study, we took advantage of RNA interference (RNAi) using small ... [more ▼]

The small GTPases of the Rho family are key intermediates in cellular signalling triggered by activated cell-adhesion receptors. In this study, we took advantage of RNA interference (RNAi) using small interfering RNAs (siRNAs) to define the roles of the best-characterized members of the RhoGTPase family, RhoA, Rac1 and Cdc42, in the control of MMP-1, MMP-2 and type-I-collagen expression in normal human skin fibroblasts (HSFs). A specific and long-lasting repression, up to 7 days after transfection, of the three GTPases was achieved by transient transfection of specific siRNA. The silencing of Cdc42, but not that of RhoA or Rac1, induced a 15-fold increase in MMP-1 secretion. This upregulation was confirmed at the mRNA level and observed with two different siRNAs targeting Cdc42. Such a regulation was also observed in various human cell lines and was rescued by re-expressing wild-type Cdc42 encoded by a construct bearing silent mutations impeding its recognition by the siRNA. By contrast, MMP-2 and type-I-collagen expression was not affected by the individual silencing of each Rho GTPase. Cytokine protein array, enzyme-linked immunosorbent assays and reverse-transcription PCR measurements revealed that ablation of Cdc42 induced an overexpression of interleukin 8 and MCP-1. Although these cytokines are known to induce the expression of MMP-1, we showed that they were not involved in the Cdc42-mediated upregulation of MMP-1. Silencing of Cdc42 also induced an increased phosphorylation of ERK1/2 and p38 MAP kinase. The use of chemical inhibitors on Cdc42-ablated cells revealed that the upregulation of MMP-1 is dependent on the ERK1/2 pathways, whereas the p38 MAP kinase pathway displayed an inhibitory role. Simultaneous knock-down of two or three Rho GTPases allowed us to demonstrate that the RhoA-ROCK pathway was not involved in this regulation but that the silencing of Rac1 reduced the effect of Cdc42 suppression. These data suggest that, in vivo, when cell/extracellular-matrix interactions via integrins induce cytoskeleton organization, MMP-1 expression is maintained at a low level by Cdc42 via a repression of the Rac1 and ERK1/2 pathways. Therefore, Cdc42 contributes to ECM homeostasis and connective tissue integrity. [less ▲]

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See detailPas d’avenir sans les filles
Lafontaine, Dominique ULg

in TRACeS de ChanGements (2005), 170(2), 2

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See detailL'évaluation des compétences, une entreprise impossible ? (Résolution de problèmes complexes et maîtrise de procédures mathématiques)
Crahay, Marcel ULg; Detheux, Monique

in Mesure et Evaluation en Education [=MEE] (2005), 28(1), 57-58

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See detailDiabetes mellitus in the elderly: insulin resistance and/or impaired insulin secretion?
Scheen, André ULg

in Diabètes & Métabolism (2005), 31 Spec No 2

Elderly people are more glucose intolerant and insulin resistant than young individuals, and many of them will develop type 2 diabetes. It remains, however, controversial whether this decrease in function ... [more ▼]

Elderly people are more glucose intolerant and insulin resistant than young individuals, and many of them will develop type 2 diabetes. It remains, however, controversial whether this decrease in function is due to an inevitable consequence of "biological aging" or due to environmental or lifestyle variables. Indeed, increased adiposity/altered fat distribution, decreased fat free mass/abnormal muscle composition, poor dietary habits and physical inactivity all contribute to reduce insulin sensitivity. Insulin resistance in elderly people appears to predominate in skeletal muscle, whereas hepatic glucose output seems to be almost unaffected. Several abnormalities in islet beta-cell and insulin secretion were also pointed out in elderly people such as increased amyloid deposition and decreased amylin secretion, impaired insulin secretion pulsatility, decreased insulin sensitivity of pancreatic beta-cells to insulinotropic gut hormones and diminished insulin response to non-glucose stimuli such as arginine. Controversial results were reported concerning the effects of aging on absolute insulin secretion in response to oral or intravenous glucose. However, insulin secretion appears to decrease with age, with significantly diminished beta-cell sensitivity and acute insulin response to glucose, provided it is analyzed relative to concomitant decreased insulin sensitivity. Thus, there is an interplay between decreased insulin secretion and increased insulin resistance that largely explains the abnormal glucose metabolism seen in elderly. Weight loss, especially reduction of abdominal adiposity, and increased physical activity may contribute to improve insulin sensitivity and glucose tolerance, and prevent the development of type 2 diabetes in elderly people. [less ▲]

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See detailL'anémie par spoliation sanguine volontaire : le syndrome de Lasthénie de Ferjol
Farcy, L.; Fillet, Georges ULg; Couvreur, Véronique ULg et al

in Revue Médicale de Liège (2005), 60(9), 719-723

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See detailL'image du mois. Une image de "lâcher de ballons" à l'imagerie thoracique
Wauters, O.; Sautois, Brieuc ULg; Fillet, Georges ULg

in Revue Médicale de Liège (2005), 60

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