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See detailInfluence du degré de mouture et de l'extrusion sur la valeur nutritionnelle de la graine de lupin
Froidmont, Eric; Bonnet, Maxime; Beckers, Yves ULg et al

in Rencontres autour des Recherches sur les Ruminants (2006), 12

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See detailInfluence of excessive carbides upon strength of hot rolled rolls of steel similar to high speed grade
Lecomte-Beckers, Jacqueline ULg; Herman, M.; Breyer, J. P.

in Stal' (2006), 9

This paper will illustrate the choice of the alloying elements and their content in the current grade. By using sophisticated laboratory examination techniques such as differential thermal analysis ... [more ▼]

This paper will illustrate the choice of the alloying elements and their content in the current grade. By using sophisticated laboratory examination techniques such as differential thermal analysis, scanning electron microscopy and image analysis, the metallurgical parameters of Aurora grade will be described and compared to those of the Kosmos grade. An attempt will also be made to connect all our laboratory results to the good behaviour of the alloy in operation in the early stands of Hot Strip Mills. [less ▲]

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See detailCPT-11 and concomitant hyperfractionated accelerated radiotherapy induce efficient local control in rectal cancer patients: results from a phase II
Voelter, V; Zouhair, A; Vuilleumier, H et al

in British Journal of Cancer (2006), 95

Patients with rectal cancer are at high risk of disease recurrence despite neoadjuvant radiochemotherapy with 5-Fluorouracil (5FU), a <br />regimen that is now widely applied. In order to develop a ... [more ▼]

Patients with rectal cancer are at high risk of disease recurrence despite neoadjuvant radiochemotherapy with 5-Fluorouracil (5FU), a <br />regimen that is now widely applied. In order to develop a regimen with increased antitumour activity, we previously established the <br />recommended dose of neoadjuvant CPT-11 (three times weekly 90 mgm 2) concomitant to hyperfractionated accelerated <br />radiotherapy (HART) followed by surgery within 1 week. Thirty-three patients (20 men) with a locally advanced adenocarcinoma of <br />the rectum were enrolled in this prospective phase II trial (1 cT2, 29 cT3, 3 cT4 and 21 cNþ). Median age was 60 years (range 43– <br />75 years). All patients received all three injections of CPT-11 and all but two patients completed radiotherapy as planned. Surgery <br />with total mesorectal excision (TME) was performed within 1 week (range 2–15 days). The preoperative chemoradiotherapy was <br />overall well tolerated, 24% of the patients experienced grade 3 diarrhoea that was easily manageable. At a median follow-up of 2 <br />years no local recurrence occurred, however, nine patients developed distant metastases. The 2-year disease-free survival was 66% <br />(95% confidence interval 0.48–0.83). Neoadjuvant CPT-11 and HART allow for excellent local control; however, distant relapse <br />remains a concern in this patient population. [less ▲]

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See detailTechnique d'extraction de 12 benzodiazépines dans le plasma. Résultats expérimentaux multicentriques
Jourdil, Nicole; Capolaghi, Bernard; Artur, Michèle et al

in Annales de Toxicologie Analytique (2006), 2

Dans le cadre des différents thèmes de travail proposés aux membres de la commission de Toxicologie Clinique de la SFTA, une étude est réalisée sur l'identification et la quantification simultanée de 12 ... [more ▼]

Dans le cadre des différents thèmes de travail proposés aux membres de la commission de Toxicologie Clinique de la SFTA, une étude est réalisée sur l'identification et la quantification simultanée de 12 benzodiazépines dans le plasma. L'objectif est de tester la robustesse d'une technique d'extraction en l'imposant aux différents participants, les conditions chromatographiques de séparation et le mode de détection restant libres, fonctions de l'équipement de chaque laboratoire. L'étude a été réalisée sur une période de 2 mois et demi. Deux échantillons tests de plasmas surchargés avec 12 benzodiazépines à des concentrations thérapeutiques ou supra-thérapeutiques sont adressés à chaque centre d'investigation en vue de leur évaluation. La technique d'extraction utilise un mélange d'hexane / dichlorométhane en milieu tamponné (pH 9.2) et le loflazépate d'éthyle comme standard interne. Une méthode CLHP avec détecteur à barrette de diode est proposée à défaut par le laboratoire coordonnateur aux participants ne disposant pas de technique d'analyse. Sur les 11 participants, 10 utilisent une technique CLHP, un seul une technique CPG. Parmi les techniques CLHP, 2 d'entre elles associent un détecteur de masse, 7 un détecteur à barrette de diodes, 1 un détecteur UV. La technique CPG est associée à un détecteur de masse. L'analyse des résultats montre que la technique d'extraction proposée a été testée avec succès par 8/11 des participants : 4/11 laboratoires sans erreur et 4/11 laboratoires avec 1 ou 2 résultats exclus. Par contre, 3/11 laboratoires ont rencontré des difficultés majeures : un site par la survenue d'émulsions lors du traitement des échantillons tests (plasmas lyophilisés à reconstituer), un site par manque de temps et d'expérience, le troisième mettant en cause le choix du standard interne en technique CPG, le loflazépate d'éthyle n'ayant pas fait l'objet d'une étude préalable par cette technique. [less ▲]

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See detailIntoxications au dextropropoxyphène et au tramadol: bilan d'un an de recueil
Cohen, Sabine; Manchon, Monique; Artur, Michèle et al

in Annales de Toxicologie Analytique (2006), 2

La prescription de plus en plus fréquente du dextropropoxyphène (DP) et du tramadol, deux antalgiques opioïdes, a conduit les membres du groupe de travail "Toxicologie hospitalière" de la Société ... [more ▼]

La prescription de plus en plus fréquente du dextropropoxyphène (DP) et du tramadol, deux antalgiques opioïdes, a conduit les membres du groupe de travail "Toxicologie hospitalière" de la Société Française de Toxicologie Analytique (SFTA) à étudier leur toxicité clinique observée. L'étude a consisté en l'analyse des cas où l'une ou l'autre de ces molécules a été identifiée au décours d'un screening toxicologique réalisé durant l'année 2004 dans les laboratoires hospitaliers des membres de ce groupe. Pour chaque patient ont été recueillis les données démographiques, les concentrations plasmatiques en dextropropoxyphène, norpropoxyphène (NP) ou tramadol, la concentration plasmatique en paracétamol, les médicaments associés et les signes cliniques (digestifs, respiratoires, cardiaques et neurologiques). Aucune relation entre les concentrations plasmatiques de dextropropoxyphène et de paracétamol, ni entre celles de dextropropoxyphène ou de tramadol et la gravité clinique n'a été observée. Les concentrations plasmatiques observées en dextropropoxyphène sont faibles mais doivent attirer l'attention sur une éventuelle intoxication au paracétamol. Les concentrations plasmatiques en tramadol peuvent être élevées mais les intoxications sont dans l'ensemble peu sévères et les concentrations toxiques semblent très supérieures à la concentration de 1 mg/L. [less ▲]

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See detailPortfolio professionnel
Georges, François ULg

Master of advanced studies dissertation (2006)

Porfolio professionnel dans lequel l'enseignant donne sa vision de l'enseignement, analyse les données récoltées suite à l'introduction d'une innovation apportée dans son enseignement et apporte les ... [more ▼]

Porfolio professionnel dans lequel l'enseignant donne sa vision de l'enseignement, analyse les données récoltées suite à l'introduction d'une innovation apportée dans son enseignement et apporte les preuves de sa professionnalisation dans le domaine de l'apprentissage. L'innovation a trait à la conception et l'implémentation d'un outil de gestion individualisée des compétences. [less ▲]

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See detailNonlocal magnetic field-tuned quantum criticality in cubic CeIn3-xSnx (x=0.25)
Silhanek, Alejandro ULg; Ebihara, Takao; Harrison, N. et al

in Physical Review Letters (2006), 96(20),

We show that antiferromagnetism in lightly (approximate to 8%) Sn-doped CeIn3 terminates at a critical field mu H-0(c)=42 +/- 2 T. Electrical transport and thermodynamic measurements reveal the effective ... [more ▼]

We show that antiferromagnetism in lightly (approximate to 8%) Sn-doped CeIn3 terminates at a critical field mu H-0(c)=42 +/- 2 T. Electrical transport and thermodynamic measurements reveal the effective mass m(*) not to diverge, suggesting that cubic CeIn3 is representative of a critical spin-density wave (SDW) scenario, unlike the local quantum critical points reported in anisotropic systems such as CeCu6-xAux and YbRh2Si2-xGex. The existence of a maximum in m(*) at a lower field mu H-0(x)=30 +/- 1 T may be interpreted as a field-induced crossover from local moment to SDW behavior as the Neel temperature falls below the Fermi temperature. [less ▲]

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See detailPhysical and chemical properties of pyropheophorbide)a-methyl ester in ethanol, phosphate buffer and aqueous dispersion of small unilamellar dimyristoyl-L-a-phosphatidylcholine vesicles
Delanaye, Lisiane; Bahri, Mohamed Ali ULg; Tfibel, Francis et al

in Photochemical & Photobiological Sciences (2006), 5

The aggregation process of pyropheophorbide-a methyl ester (PPME), a second generation hotosensitizer, was investigated in various solvents. Absorption and fluorescence spectra showed that the ... [more ▼]

The aggregation process of pyropheophorbide-a methyl ester (PPME), a second generation hotosensitizer, was investigated in various solvents. Absorption and fluorescence spectra showed that the photosensitizer was under a monomeric form in ethanol as well as in dimyristoyl-L-α-phosphatidylcholine liposomes while it was strongly aggregated in phosphate buffer. A quantitative determination of reactive oxygen species production by PPME in these solvents has been undertaken by electron spin resonance associated with spin trapping technique and absorption spectroscopy. In phosphate buffer, both electron spin resonance and absorption measurements led to the conclusion that singlet oxygen production was not detectable while hydroxyl radical production was very weak. In liposomes and ethanol, singlet oxygen and hydroxyl radical production increased highly; the singlet oxygen quantum yield was determined to be 0.2 in ethanol and 0.13 in liposomes. The hydroxyl radical production origin was also investigated. Singlet oxygen was formed from PPME triplet state deactivation in presence of oxygen. Indeed, the triplet state formation quantum yield of PPME was found to be about 0.23 in ethanol, 0.15 in liposomes (too small to be measured in PBS). [less ▲]

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See detaileCole - Projet d'apprentissage et de remédiation en ligne
Vreeswijk, Valérie ULg; Brundseaux, Marie-France ULg; Georges, François ULg et al

Report (2006)

Recherche-développement consacrée à la conception d'un dispositif en ligne susceptible de soutenir l'autonomisation des apprenants dans le déploiement des compétences "lire" et "écrire" en français.

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See detailComment j'explore...une chéilite.
Goffin, Véronique ULg; Blaise, G.; Henry, Frédérique ULg et al

in Revue Médicale de Liège (2006), 61(11), 780-2

A cheilitis is an inflammatory disease confined to the lips. Several origins are recognized. Their nature is often different in children and adults. Some are spongiotic due to irritation or allergic ... [more ▼]

A cheilitis is an inflammatory disease confined to the lips. Several origins are recognized. Their nature is often different in children and adults. Some are spongiotic due to irritation or allergic reaction. Other lesions are keratotic and can evolve to leucoplasia and epidermoid carcinoma. [less ▲]

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See detailSkin capacitance imaging, a new technique for investigating the skin surface.
Leveque, Jean-Luc; Xhauflaire, Emmanuelle ULg; Pierard, Gérald ULg

in European Journal of Dermatology (2006), 16(5), 500-6

Thanks to the recently introduced silicone image sensor technology, skin capacitance imaging has now been made possible. The dedicated device is called SkinChip. This method is easy to handle and provides ... [more ▼]

Thanks to the recently introduced silicone image sensor technology, skin capacitance imaging has now been made possible. The dedicated device is called SkinChip. This method is easy to handle and provides information about the skin microrelief, the level of stratum corneum hydration and the sweat gland activity. The apparatus sees and measures these parameters with a 50 microm resolution. A series of conditions have been explored using skin capacitance imaging. This review summarizes relevant findings about regional variability on the body, changes occurring with ageing, effects of a hydrating formulation, reactivity kinetics of corneocytes to surfactants, acne and skin pores characteristics, as well as hyperkeratotic dermatoses and tumours. [less ▲]

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See detailUtilisation des microscories métallurgiques comme traceur de la sédimentation dans les plaines alluviales ardennaises
Houbrechts, Geoffrey ULg; Petit, François ULg

in l'érosion entre société, climat et paléoenvironnement (2006)

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See detailImplicit memory during isoflurane anesthesia - Reply
Iselin-Chaves, Irène A.; Willems, Sylvie ULg

in Anesthesiology (2006), 105(2), 430-430

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See detailImpact of work variables and safety appraisal on well-being at work
Hansez, Isabelle ULg; Taeymans, sophie; Nyssen, Anne-Sophie ULg

in Pikaar, R. N.; Koningsveld, E. A. P.; Settels (Eds.) Proceedings of the 16th World Congress of Ergonomics (2006)

Work environments have been encountering tremendous changes since the early 1990s. The enlargement of flexibility practices has raised concerns about well-being at work but also about safety. These two ... [more ▼]

Work environments have been encountering tremendous changes since the early 1990s. The enlargement of flexibility practices has raised concerns about well-being at work but also about safety. These two research areas, i.e. safety and well-being at work, have a strong tradition of diagnosis and research but there are few examples in the literature that attempt to link the two areas. Our goal in this study was to analyze the impact of both work variables and safety appraisal on well-being within a context of organizational changes. We used questionnaires on 4297 workers from a large company in the energy sector that has encountered big organizational changes these last years. Job control dimensions, safety appraisal, eustress and distress were measured using existing questionnaires. The results give some evidence for an additive explanation of eustress when adding safety appraisal in the hierarchical regression analysis. The additive effect of safety appraisal on distress was also significant but not enough strong to be considered seriously. A path analysis has shown that the effect of management safety climate on distress was rather an indirect effect through the job control dimensions. [less ▲]

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See detailNon-infusional vs intravenous consolidation chemotherapy in eldery patients with acute myeloid leukemia : final results of th EORTC-GIMAMA AML-13 randomized phase III trial
Jehn, U.; Suciu, S.; Thomas, X. et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (2006), 20

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See detailRimonabant improves health-related quality of life in overweight/obese patients with type 2 diabetes: RIO-diabetese study
Kolotkin, R. L.; Crosby, R. D.; Scheen, André ULg

in Value in Health (2006), 9(6, NOV-DEC), 327

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See detailPrise en charge de l'insuffisance rénale chronique légère à modérée
Krzesinski, Jean-Marie ULg; Crismer, André ULg

in Revue Médicale de Liège (2006), 61(5-6, May-Jun), 405-13

The prevalence of chronic renal insufficiency, the cost related to its presence and the associated high cardiovascular risk are increasing. Early detection is needed, with, in parallel, identification of ... [more ▼]

The prevalence of chronic renal insufficiency, the cost related to its presence and the associated high cardiovascular risk are increasing. Early detection is needed, with, in parallel, identification of all frequently associated cardiovascular risk factors. The general practitioner here plays a major role. Sometimes, a first reference to the nephrologist is requested, for instance in the presence of a nephritic or nephrotic syndrome, of an alteration of glomerular filtration rate without any clear explanation , or of a rather advanced renal dysfunction (a GFR < 60 ml/min in people < 65 years or < 45 ml/min in the others). This paper is concerned with mild and moderate forms of kidney disease (stages 1 to 3). In case of progression, a closer collaboration must exist between the general practitioner, the nephrologist and a trained dietician to slow down this progression, limit its consequences and delay as long as possible the initiation of kidney function supplying techniques. [less ▲]

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See detailType 1 diabetes susceptibility loci from genome scans in multiplex families
Geenen, Vincent ULg

in International Diabetes Monitor (2006), 18

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See detailDecision making numerical tools for the rehabilitation of hydraulic structures - Application to the Nisramont dam in Belgium
Erpicum, Sébastien ULg; Archambeau, Pierre ULg; Dewals, Benjamin ULg et al

in Proceedings of the ICOLD 22th Congress (2006)

In the global framework of climate change, hydraulic structures rehabilitation is an up-to-date subject requiring appropriate design and impact studies. In this scope, upgrading the release facilities of ... [more ▼]

In the global framework of climate change, hydraulic structures rehabilitation is an up-to-date subject requiring appropriate design and impact studies. In this scope, upgrading the release facilities of dams is an important point since any badly controlled rise of water level in the reservoir leads usually to both up and downstream consequences, often irreversible. Suitable numerical models, coupled with contemporary computational possibilities, allow today engineers to forecast the complex situations induced on real structures by extreme events with increasing representativeness and accuracy. In this field, WOLF software, a process oriented free surface flows computation package completely set up by the HACH team, has proved its efficiency and reliability for years through numerous theoretical, experimental as well as on real structures applications. In this paper, the rehabilitation study of the Nisramont dam (Belgium) is presented. Located on the Ourthe River, a few kilometers upstream of the town of La Roche, this 21-meter high dam came into service in 1958 and was, in a first time, dedicated to be used as a cofferdam during the construction of a downstream larger reservoir of 250 hm³. But this second dam was never built and Nisramont became a definitive reservoir of 3 hm³ assuming the drinking water supply of a large part of the population of the south of Belgium and producing hydro-electricity. Due to its temporary primary tasks, the stilling basin downstream of the three 12.5 m large notches of the crest spillway has been designed for a short time use. Similarly, the 3 bottom outlets have never been equipped with valves and are thus unusable for the reservoir management. In order to secure the structure and to make it comply with its definitive working objectives, while taking into account climate change observations, the Ministère wallon de l’Equipement et des Transport (MET) - Direction des barrages de l’Est (D. 241) entrusted the HACH with evaluating up to date critical flood discharges and with designing a system in accord with these new values for the rehabilitation of the bottom outlets and the evacuation of the floods to the downstream river. This study has mainly been carried out using software of the WOLF package, successively applied to model really observed extreme events on the structure, to define new peak flow discharge and to design the stilling basin. [less ▲]

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