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See detailReconstruire la ville sur la ville - Recyclage des espaces dégradés
Govearts, Pierre; Timmermans, Anne; Vanloquerena, Tanguy et al

Report (2003)

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See detailPlace du traitement substitutif de la menopause 1 an apres la publication des resultats de l'etude WHI (Women's Health Initiative)
Pintiaux, Axelle ULg; Van den Brule, F.; Foidart, Jean-Michel ULg et al

in Revue Médicale de Liège (2003), 58(9), 572-5

The currently reported data concerning the large WHI randomized controlled trial compare the impact of continuous combined conjugated estrogens + medroxyprogesterone acetate vs placebo in postmenopausal ... [more ▼]

The currently reported data concerning the large WHI randomized controlled trial compare the impact of continuous combined conjugated estrogens + medroxyprogesterone acetate vs placebo in postmenopausal women. These results appear largely pessimistic. After 5.2 years of hormone replacement, an excess of coronary heart disease, cerebrovascular disease, venous thromboembolism, breast cancer incidence and extension, mild cognitive impairment and dementia is recorded. By contrast, osteoporotic fracture risk and colorectal cancer are decreased during hormone replacement. Accordingly, this hormonal treatment can no longer be recommended on a long term basis, except after extensive risk-benefit balance evaluation. It should no longer be prescribed for prevention of chronic diseases. It remains indicated during 4-5 years for relief of vasomotor symptoms, genital atrophy and, potentially, for some aspects of quality of life. HRT should probably be prescribed in minimal-effective dosages; new regimens, routes of administration, new compounds and associations should be envisaged in order to avoid cardiovascular or breast problems. However these new approaches ask for thorough validation studies. [less ▲]

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See detailPatrimoine naturel
Feltz, Claude ULg; Melin, Eric ULg

Report (2003)

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See detailPatrimoine paysager
Feltz, Claude ULg; Melin, Eric ULg

Report (2003)

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See detailLiver transplantation for metastatic colon adenocarcinoma: report of a case with 10 years of follow-up without recurrence
Honore, Charles ULg; Detry, Olivier ULg; De Roover, Arnaud ULg et al

in Transplant International (2003), 16(9), 692-693

Because of dismal mid-term and long-term results, secondary liver cancer is considered an absolute contra-indication to cadaveric liver transplantation, with the relative exception of metastases of ... [more ▼]

Because of dismal mid-term and long-term results, secondary liver cancer is considered an absolute contra-indication to cadaveric liver transplantation, with the relative exception of metastases of symptomatic neuro-endocrine cancers. The authors present in this report the case of a patient who has been enjoying 10 years of cancer-free survival after liver transplantation as rescue therapy for acute liver failure after liver resection for isolated hepatic metastasis of colon adenocarcinoma. This case shows that in some highly selected cases, liver transplantation may be curative in patients with liver metastases of colon carcinoma. [less ▲]

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See detailY a-t-il une place d'emblée pour une bithérapie faiblement dosée dans le traitement de l'hypertension artérielle essentielle?
Krzesinski, Jean-Marie ULg; Rorive, Marcelle ULg

in Médecine et Hygiène (2003), 61

If the treatment of hypertension is very useful to decrease the cardiovascular risk, the way to get the normalisation of high blood pressure is difficult in spite of many families of antihypertensive ... [more ▼]

If the treatment of hypertension is very useful to decrease the cardiovascular risk, the way to get the normalisation of high blood pressure is difficult in spite of many families of antihypertensive agents with different mechanisms of action. To reach such objective, association of different drugs are most often required. But, the european guidelines for the management of hypertension have just been released and proposed the possibility to begin very-low-dose combination therapy first-line. These associations offer immediate higher efficacy, excellent tolerance and low cost. [less ▲]

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See detailPiloter le futur ...
Van Caillie, Didier ULg

Article for general public (2003)

This chronicle insists on the importance of monitoring the future in firms, independently from their size, and on the interest for using performance management tools such as "Balanced Scorecards" to ... [more ▼]

This chronicle insists on the importance of monitoring the future in firms, independently from their size, and on the interest for using performance management tools such as "Balanced Scorecards" to monitor uncertain environments. [less ▲]

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See detailMagnetically controlled ballistic deposition. A model of polydisperse granular packing
Trojan, K.; Ausloos, Marcel ULg

in Physica A-Statistical Mechanics and its Applications (2003), 326(3-4), 492-510

The flow and deposition of polydisperse granular materials is simulated through the magnetic diffusion limited aggregation (MDLA) model. The random walk undergone by an entity in the MDLA model is ... [more ▼]

The flow and deposition of polydisperse granular materials is simulated through the magnetic diffusion limited aggregation (MDLA) model. The random walk undergone by an entity in the MDLA model is modified such that the trajectories are ballistic in nature, leading to a magnetically controlled ballistic deposition (MBD) model. This allows to obtain important ingredients about a difficult problem that of the nonequilibrium segregation of polydisperse sandpiles and heterogeneous adsorption of a binary distribution of particles which can interact with each other and with an external field. Our detailed results from many simulations of MBD clusters on a two-dimensional triangular lattice above a flat surface in a vertical finite size box for binary systems indicates intriguing variations of the density, "magnetization", types of clusters and fractal dimensions. We derive the field and grain interaction-dependent susceptibility and compressibility. We deduce a completely new phase diagram for binary granular piles and discuss its complexity inherent to different grain competition and cluster growth probabilities. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]

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See detailBulletin agrométéorologique - Juillet 2003
Tychon, Bernard ULg; Ozer, Pierre ULg; Eerens, H. et al

in Bulletin Agrométéorologique (2003)

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See detailA camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme
Dumoulin, Mireille ULg; Last, A. M.; Desmyter, A. et al

in Nature (2003), 424(6950), 783-788

Amyloid diseases are characterized by an aberrant assembly of a specific protein or protein fragment into fibrils and plaques that are deposited in various organs and tissues(1-3), often with serious ... [more ▼]

Amyloid diseases are characterized by an aberrant assembly of a specific protein or protein fragment into fibrils and plaques that are deposited in various organs and tissues(1-3), often with serious pathological consequences. Non-neuropathic systemic amyloidosis (4-6) is associated with single point mutations in the gene coding for human lysozyme. Here we report that a single-domain fragment of a camelid antibody(7-9) raised against wild-type human lysozyme inhibits the in vitro aggregation of its amyloidogenic variant, D67H. Our structural studies reveal that the epitope includes neither the site of mutation nor most residues in the region of the protein structure that is destabilized by the mutation. Instead, the binding of the antibody fragment achieves its effect by restoring the structural cooperativity characteristic of the wild-type protein. This appears to occur at least in part through the transmission of long-range conformational effects to the interface between the two structural domains of the protein. Thus, reducing the ability of an amyloidogenic protein to form partly unfolded species can be an effective method of preventing its aggregation, suggesting approaches to the rational design of therapeutic agents directed against protein deposition diseases. [less ▲]

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See detailOn the substrate specificity of bacterial DD-peptidases: evidence from two series of peptidoglycan-mimetic peptides
Anderson, J. W.; Adediran, S. A.; Charlier, Paulette ULg et al

in Biochemical Journal (2003), 373(Part 3), 949-955

The reactions between bacterial DD-peptidases and beta-lactam antibiotics have been studied for many years. Less well understood are the interactions between these enzymes and their natural substrates ... [more ▼]

The reactions between bacterial DD-peptidases and beta-lactam antibiotics have been studied for many years. Less well understood are the interactions between these enzymes and their natural substrates, presumably the peptide moieties of peptidoglycan. In general, remarkably little activity has previously been demonstrated in vitro against potential peptide substrates, although in many cases the peptides employed were non-specific and not homologous with the relevant peptidoglycan. In this paper, the specificity of a panel of DD-peptidases against elements of species-specific D-alanyl-D-alanine peptides has been assessed. In two cases, those of soluble, low-molecular-mass DD-peptidases, high activity against the relevant peptides has been demonstrated. In these cases, the high specificity is towards the free N-terminus of the peptidoglycan fragment. With a number of other enzymes, particularly high-molecular-mass DD-peptidases, little or no activity against these peptides was observed. In separate experiments, the reactivity of the enzymes against the central, largely invariant, peptide stem was examined. None of the enzymes surveyed showed high activity against this structural element although weak specificity in the expected direction towards the one structural variable (D-gammaGln versus D-gammaGlu) was observed. The current state of understanding of the activity of these enzymes in vitro is discussed. [less ▲]

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See detailEffects of endotoxic shock on right ventricular systolic function and mechanical efficiency
Lambermont, Bernard ULg; Ghuysen, Alexandre ULg; Kolh, Philippe ULg et al

in Cardiovascular Research (2003), 59(2), 412-418

Objective: To investigate the effects of endotoxin infusion on right ventricular (RV) systolic function and mechanical efficiency. Methods: Six anesthetized pigs (Endo group) received a 0.5 mg/kg ... [more ▼]

Objective: To investigate the effects of endotoxin infusion on right ventricular (RV) systolic function and mechanical efficiency. Methods: Six anesthetized pigs (Endo group) received a 0.5 mg/kg endotoxin infusion over 30 min and were compared with six other anesthetized pigs (Control group) receiving placebo for 5 h. RV pressure-volume (PV) loops were obtained by the conductance catheter technique and pulmonary artery flow and pressure were measured with high-fidelity transducers. Results: RV adaptation to increased afterload during the early phase of endotoxin-induced pulmonary hypertension (T30) was obtained by both homeometric and hetereometric regulations: the slope of the end-systolic PV relationship of the right ventricle increased from 1.4+/-0.2 mmHg/ml to 2.9+/-0.4 mmHg/ml (P<0.05) and RV end-diastolic volume increased from 56+/-6 ml to 64+/-11 ml (P<0.05). Consequently, right ventricular-vascular coupling was maintained at a maximum efficiency. Ninety minutes later (T120), facing the same increased afterload, the right ventricle failed to maintain its contractility to such an elevated level and, as a consequence, right ventricular-vascular uncoupling occurred. PV loop area, which is known to be highly correlated with oxygen myocardial consumption, increased from 1154+/-127 mmHg/ml (T0) to 1798+/-122 mmHg/ml (T180) (P<0.05) while RV mechanical efficiency decreased from 63+/-2% (T0) to 45+/-5% (T270) (P<0.05). Conclusions: In the very early phase of endotoxinic shock, right ventricular-vascular coupling is preserved by an increase in RV contractility. Later, myocardial oxygen consumption and energetic cost of RV contractility are increased, as evidenced by the decrease in RV efficiency, and right ventricular-vascular uncoupling occurs. Therefore, therapies aiming at restoring right ventricular-vascular coupling in endotoxic shock should attempt to increase RV contractility and to decrease RV afterload but also to preserve RV mechanical efficiency. (C) 2003 European Society of Cardiology. Published by Elsevier B.V. All rights reserved. [less ▲]

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See detailFavourable outcome of a brain trauma patient despite bilateral loss of cortical somatosensory evoked potential during thiopental sedation
Robe, Pierre; Dubuisson, Annie ULg; Bartsch, Sébastien et al

in Journal of Neurology, Neurosurgery & Psychiatry (2003), 74(8), 1157-1158

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See detailAn efficient decentralized on-line traffic engineering algorithm for MPLS networks
Blanchy, François; Mélon, Laurent; Leduc, Guy ULg

in Providing Quality of Service in Heterogeneous Environments (2003, August)

Multi-Protocol Label Switching (MPLS) provides ways to control the Label Switched Paths (LSPs) followed by traffic trunks in a network and thereby to better traffic engineer it. In this context, we look ... [more ▼]

Multi-Protocol Label Switching (MPLS) provides ways to control the Label Switched Paths (LSPs) followed by traffic trunks in a network and thereby to better traffic engineer it. In this context, we look at the problem of organizing the mapping of LSPs in an optimal way throughout the network on the basis of a given objective function. This problem is highly combinatorial and makes dynamic and real-time features a difficult issue for any LSP routing scheme. For this reason, we propose a computationally efficient, though approximate, on-line scheme adapted to an incremental optimization of the network state. It is then applied to a seldom mentioned traffic engineering problem: the compromise between load-balancing and traffic minimization. It is expected that clever routing strategies to balance the network load will sometimes favor longer paths in order to avoid congestion, leading to an increase of the overall network utilization. This reasoning is confirmed by our study, and we show that an improvement in network management can be made by appropriately tuning this compromise. [less ▲]

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See detailCrystal structure of Enterobacter cloacae 908R class C beta-lactamase bound to iodo-acetamido-phenyl boronic acid, a transition-state analogue
Wouters, J.; Fonze, E.; Vermeire, M. et al

in Cellular and Molecular Life Sciences (2003), 60(8), 1764-1773

The structures of the, class C beta-lactamase from Enterobacter cloacae 908R alone and in complex with a baronic acid transition-state analogue were determined by X-ray crystallography at 2.1 and 2.3 ... [more ▼]

The structures of the, class C beta-lactamase from Enterobacter cloacae 908R alone and in complex with a baronic acid transition-state analogue were determined by X-ray crystallography at 2.1 and 2.3 Angstrom, respectively. The structure of the enzyme resembles those of other class C beta-lactamases. The structure of the. complex with the transition-state analogue, iodo-acetamido-phenyl boronic acid, shows that the inhibitor is covalently, bound to the active-site serine (Ser64). Binding of the inhibitor within the active site is compared with previously determined structures of complexes with other class C enzymes. The structure of the boronic acid adduct indicates ways to improve the affinity of this class of inhibitors. This structure of 908R class C beta-lactamase in complex with a transitionstate analogue provides further insights into the mechanism of action of these hydrolases. [less ▲]

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See detailGuidelines for percutaneous coronary intervention by the Belgian Working Group on Invasive Cardiology
Legrand, Victor ULg; Wijns, W.; Vandenbranden, F. et al

in Acta Cardiologica (2003), 58(4), 341-348

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See detailFaunal/floral and isotopic responses to Milankovitch precession cycles and environmental changes in the upper Gulpen Formation (Upper Maastrichtian) at the CBR-Lixhe and ENCI-Maastricht bv quarries
Felder, P. J.; Keppens, E.; De Clercq, Bernadette ULg et al

in Netherlands Journal of Geosciences-Geologie en Mijnbouw (2003), 82(3), 275-281

Two sections, just below the Nivelle Horizon in the upper Gulpen Formation (Upper Maastrichtian), and seven kilometres apart (CBR-Lixhe and ENCI-Maastricht bv quarries) have been analysed (samples every 5 ... [more ▼]

Two sections, just below the Nivelle Horizon in the upper Gulpen Formation (Upper Maastrichtian), and seven kilometres apart (CBR-Lixhe and ENCI-Maastricht bv quarries) have been analysed (samples every 5 cm) for dinocyst, pollen grains and bioclast contents as well as for carbon and oxygen isotopic composition, to obtain better insight into the influence of weathering on these sediments. The CBR section lies above groundwater level, while that at the ENCI quarry is some metres below. At the former quarry we recognised the influences of weathering (karst) nearby. At ENCI, palynological, bioclast and stable isotope results of the carbonate phase (mainly consisting of coccoliths) co-vary remarkably, displaying two cycles which may be interpreted tentatively as climatic fluctuations. The partial derivative(18)O curve varies roughly between -1.6parts per thousand and -1.1parts per thousand (on PDB scale), corresponding to a temperature change of about 2degreesC. Less negative values (i.e. cooler seawater) coincide with larger amounts of pollen of Normapolles and Triporates type assumed to represent temperate forest elements of a vegetation also containing tropical elements such as palms. Assuming the 5 cm sample intervals at ENCI to correspond to 1 ka, climatic maxima (and minima) may be 20-25 ka apart, obviously recalling Milankovitch precession cycles. These are independent of a sharp sedimentological change noted in the upper part of the lowest cycle (samples 42 to 24). Upwards of sample 42, bioclast contents increase and dinocysts, Spiniferites in particular, decrease significantly, corresponding to a marked shallowing. This turning point is also recorded in the partial derivative(13)C curve at ENCI. Bioclast percentages appear to follow composite trends that are influenced by both climatic and sedimentological conditions. [less ▲]

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