Publications ORBi OA
Bookmark and Share    
Full Text
Peer Reviewed
See detailStudy of bendability of steel sheets
Ben Bettaieb, Mohamed ULg; Lemoine, Xavier; Duchene, Laurent ULg et al

in Steel Research International (2008), (79/1), 225-232

In the present contribution bending tests are modeled and the bendability of steel sheets is evaluated. Bendability refers to the ratio of the minimum bend radius to the initial sheet thickness at which ... [more ▼]

In the present contribution bending tests are modeled and the bendability of steel sheets is evaluated. Bendability refers to the ratio of the minimum bend radius to the initial sheet thickness at which the bending proc-ess is successfully accomplished [1]. The metallurgic microstructure of the studied sheet consists in two principal phases: a fully dense matrix (which may be itself composed by several metallurgic phases) and spherical voids. For that purpose, the Gurson Tvergaard Needleman law ([2], [3], [4]) is used and significantly modified. The behavior of the fully dense matrix is de-fined by the anisotropic Hill 48 function and the Swift hardening law. The width of the sheet is assumed to be large enough to neglect the transversal strains and the stress component in the thickness direction is also neglected. The bending operation can thus be modelled by a plane strain-plane stress loading. The influence of mechanical pa-rameters such as the initial porosity, the Lankford coefficient and the strain harden-ing exponent on the bendability is studied herein. The failure here is defined by the onset coalescence of neighbour voids and is checked by using Thomason [5], Pardoen [6] and Brunet [7] coalescence models. So the influence of other phenomena (like the shear band development and the localized necking) on the bendability is neglected here. [less ▲]

Detailed reference viewed: 413 (37 ULg)
Full Text
Peer Reviewed
See detailThe Numerical Modeling and Measurement of Demagnetization Effect in Bulk YBCO Superconductors Subjected to Transverse Field
Hong, Z.; Vanderbemden, Philippe ULg; Pei, R. et al

in IEEE Transactions on Applied Superconductivity (2008), 18(2), 1561-1564

In this paper, the crossed field demagnetization effect of the bulk type-II superconducting materials in a variety of external magnetic field condition has been investigated both numerically and ... [more ▼]

In this paper, the crossed field demagnetization effect of the bulk type-II superconducting materials in a variety of external magnetic field condition has been investigated both numerically and experimentally. A melt-textured YBCO bulk sample was magnetized along the axial direction and after that a transverse field perpendicular to the central axis applied. The collapse of the original trapped field was measured using a Quantum Design Physical Property Measurement System. A numerical solver based on critical state model is proposed to simulate the measured results. (C) 2008 IEEE. [less ▲]

Detailed reference viewed: 70 (33 ULg)
Full Text
Peer Reviewed
See detailCritical opalescence points to thermodynamic instability:relevance to small-angle X-ray scattering of resorcinol–formaldehyde gel formation at low pH
Gommes, Cédric ULg; Job, Nathalie ULg; Pirard, Jean-Paul ULg et al

in Journal of Applied Crystallography (2008), 41(4), 663-668

During the formation at low pH of resorcinol–formaldehyde gels with a structure in the micrometre range, small-angle X-ray scattering exhibits a nonmonotonic intensity variation as a function of reaction ... [more ▼]

During the formation at low pH of resorcinol–formaldehyde gels with a structure in the micrometre range, small-angle X-ray scattering exhibits a nonmonotonic intensity variation as a function of reaction time. The data are analyzed in terms of scattering by statistical fluctuations of polymer concentration, the amplitude of which is maximal close to the critical point for phase separation between polymer and solvent. The data do not carry any morphological information, but they unambiguously show that the driving force of the gel formation is a thermodynamic instability of the polymerizing solution. [less ▲]

Detailed reference viewed: 74 (17 ULg)
Full Text
Peer Reviewed
See detailDiet and foraging ecology of Roseate terns and lesser noddies breeding sympatrically on Aride Island, Seychelles
Monticelli, David; Ramos, J. A.; Tavares, P. C. et al

in Waterbirds (2008), 31(239), 248

Inferences on seabird ecology from stable isotopes ratios (δ13C, δ15N) and mercury concentrations analysis of feathers have been made for temperate and polar species but are far more rare for tropical ... [more ▼]

Inferences on seabird ecology from stable isotopes ratios (δ13C, δ15N) and mercury concentrations analysis of feathers have been made for temperate and polar species but are far more rare for tropical species. In this paper, we used this approach combined with analysis of regurgitations and feeding observations at colonies to examine diet segregation between Roseate Terns (Sterna dougallii) and Lesser Noddies (Anous tenuirostris) breeding sympatrically on Aride Island (Seychelles), western Indian Ocean. Our results indicated extensive overlap between the two species in trophic level and foraging area during the breeding season. Goatfish predominated (93-97%) in all diet samples of adults and chicks collected in the colonies, except in prey fed to mates by Roseate Terns, of which scad and tuna comprised 20%. The isotopic analyses of feathers replaced by adults during molt (primary and body feathers) suggested, however, that the two species differ in foraging ecology during the nonbreeding period. Roseate Tern adults had consistently lower δ15N values than Lesser Noddies which, in turn, had δ15N values comparable to those of chick feathers grown on Aride. Moreover, low but similar mercury levels were found in body feathers of Lesser Noddy adults and Roseate Tern chicks, whereas Roseate Tern adults were significantly more contaminated. Overall, these results support the hypothesis that the Lesser Noddy is largely sedentary, being associated with the same food web in the vicinity of the colonies year-round. In contrast, Roseate Terns rely on distinct prey during the molting (nonbreeding) season which may be also consistent with a change in food web (i.e., a migratory regime) although the assignment of potential wintering areas remain difficult without isotopic basemaps currently available for the Indian Ocean. [less ▲]

Detailed reference viewed: 150 (6 ULg)
Full Text
See detailLe juge constitutionnel et la fiscalité négociée : le maintien des effets d'une norme annulée, applicable une seule fois
Bouhon, Frédéric ULg

in Revue de la Faculté de Droit de l'Université de Liège (2008), 4

Detailed reference viewed: 82 (17 ULg)
Full Text
Peer Reviewed
See detailUndetected changes in visible stimuli influence subsequent decisions.
Laloyaux, Cédric ULg; Devue, Christel ULg; Doyen, Stéphane et al

in Consciousness & Cognition (2008), 17(3), 646-56

Change blindness-our inability to detect changes in a stimulus-occurs even when the change takes place gradually, without any disruption [Simons, D. J., Franconeri, S. L., & Reimer, R. L. (2000). Change ... [more ▼]

Change blindness-our inability to detect changes in a stimulus-occurs even when the change takes place gradually, without any disruption [Simons, D. J., Franconeri, S. L., & Reimer, R. L. (2000). Change blindness in the absence of a visual disruption. Perception, 29(10), 1143-1154]. Such gradual changes are more difficult to detect than changes that involve a disruption. Using this method, David et al. [David, E., Laloyaux, C., Devue, C., & Cleeremans, A. (in press). Change blindness to gradual changes in facial expressions. Psychologica Belgica] recently showed substantial blindness to changes that involve facial expressions of emotion. In this experiment, we show that people who failed to detect any change in the displays were (1) nevertheless influenced by the changing information in subsequent recognition decisions about which facial expression they had seen, and (2) that their confidence in their decisions was lower after exposure to changing vs. static displays. The findings therefore support the notion that undetected changes that occur in highly salient stimuli may be causally efficacious and influence subsequent behavior. Implications concerning the nature of the representations associated with undetected changes are discussed. [less ▲]

Detailed reference viewed: 47 (3 ULg)
Full Text
Peer Reviewed
See detailNumerical Simulation of a Scroll Expander for Use in a Rankine Cycle
Lemort, Vincent ULg; Quoilin, Sylvain ULg; Lebrun, Jean ULg

(2008)

This paper presents two simulation models of scroll expanders for use in heat recovery Rankine cycle applications: a detailed reference model and a simplified model. The reference model associates a ... [more ▼]

This paper presents two simulation models of scroll expanders for use in heat recovery Rankine cycle applications: a detailed reference model and a simplified model. The reference model associates a detailed geometrical description of the expander to a thermodynamic modeling of the expansion process in the machine. Due to large computational effort, the reference model is not appropriate for simulation of the entire Rankine cycle system. The paper shows how a simplified model can be built from the reference model. This model involves a limited number of parameters, which describe the main features of the machine. An experimental study is carried out on a prototype of Rankine cycle working with HCFC-123. Based on detailed measurements, the validation of both models is conducted. It is found that both models are able to predict the mass flow rate, the delivered shaft power and the discharge temperature with a good accuracy. [less ▲]

Detailed reference viewed: 837 (41 ULg)
Full Text
Peer Reviewed
See detailAttention to self-referential stimuli: can I ignore my own face?
Devue, Christel ULg; Brédart, Serge ULg

in Acta Psychologica (2008), 128(2), 290-7

Auto-referential materials (i.e., the own name) have been described as particularly prone to capture attention. Some recent studies have questioned this view and shown that these own name effects are ... [more ▼]

Auto-referential materials (i.e., the own name) have been described as particularly prone to capture attention. Some recent studies have questioned this view and shown that these own name effects are temporary and appear only in specific conditions: when enough resources are available (Harris, C. R., & Pashler, H. (2004). Attention and the processing of emotional words and names: Not so special after all. Psychological Science, 15, 171-178) or when the own name is presented within the focus of attention if it is a task-irrelevant stimulus (Gronau, N., Cohen, A., & Ben-Shakhar, G. (2003). Dissociations of personally significant and task-relevant distractors inside and outside the focus of attention: A combined behavioral and psychophysiological study. Journal of Experimental Psychology: General, 132, 512-529). In the present study, a stimulus that is unique to each individual was used: the self-face. In Experiment 1, the self-face produced a temporary distraction when presented at fixation during a digit-parity task. However, this distraction was not different from that triggered by another highly familiar face. In Experiment 2, the self-face failed to produce interference when presented outside the focus of attention. These results confirm recent findings showing that auto-referential materials do not automatically summon attention and have a distractive power only in specific conditions. [less ▲]

Detailed reference viewed: 198 (99 ULg)
Full Text
Peer Reviewed
See detailPersonality and mental time travel: a differential approach to autonoetic consciousness.
Quoidbach, Jordi ULg; Hansenne, Michel ULg; Mottet, Caroline

in Consciousness & Cognition (2008), 17(4), 1082-92

Recent research on autonoetic consciousness indicates that the ability to remember the past and the ability to project oneself into the future are closely related. The purpose of the present study was to ... [more ▼]

Recent research on autonoetic consciousness indicates that the ability to remember the past and the ability to project oneself into the future are closely related. The purpose of the present study was to confirm this proposition by examining whether the relationship observed between personality and episodic memory could be extended to episodic future thinking and, more generally, to investigate the influence of personality traits on self-information processing in the past and in the future. Results show that Neuroticism and Harm Avoidance predict more negative past memories and future projections. Other personality dimensions exhibit a more limited influence on mental time travel (MTT). Therefore, our study provide an additional evidence to the idea that MTT into the past and into the future rely on a common set of processes by which past experiences are used to envision the future. [less ▲]

Detailed reference viewed: 169 (42 ULg)
Full Text
Peer Reviewed
See detailIf you can regulate sadness, you can probably regulate shame: Associations between trait emotional intelligence, emotion regulation and coping efficiency across discrete emotions
Mikolajczak, Moïra; Nelis, Delphine ULg; Hansenne, Michel ULg et al

in Personality & Individual Differences (2008), 44(6), 1356-1368

The construct of trait emotional intelligence [trait El] encompasses individual dispositions related to the perception, processing, regulation, and utilization of emotional information. These emotion ... [more ▼]

The construct of trait emotional intelligence [trait El] encompasses individual dispositions related to the perception, processing, regulation, and utilization of emotional information. These emotion-related dispositions are located at the lower levels of personality hierarchies. Prior studies found that trait El promoted the utilization of adaptive coping strategies to regulate stress. The present study examined (1) whether this effect would extend to other emotions and (2) whether the coping styles used to regulate a given emotion would mediate the effect of trait El on the propensity to experience that particular emotion. Analyses revealed that trait El promoted the choice of adaptive strategies not only in the case of stress, but also anger, sadness, fear, jealousy, and shame. Trait El also promoted the use of adaptive strategies to maintain joy. We also found that high trait El individuals' choice of adaptive strategies to down-regulate various negative emotions and maintain positive ones explained their decreased propensity to experience these negative emotions and their increased propensity to experience positive ones. (c) 2007 Elsevier Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 193 (12 ULg)
Full Text
Peer Reviewed
See detailL'etude clinique du mois. United Kingdom Prospective Diabetes Study: 10 ans plus tard.
Scheen, André ULg; Paquot, Nicolas ULg; Lefebvre, Pierre ULg

in Revue Médicale de Liège (2008), 63(10), 624-9

A 10-year post-trial monitoring of patients with newly diagnosed type 2 diabetes randomised in the "United Kingdom Prospective Diabetes Study" (UKPDS) demonstrated a continued reduction in microvascular ... [more ▼]

A 10-year post-trial monitoring of patients with newly diagnosed type 2 diabetes randomised in the "United Kingdom Prospective Diabetes Study" (UKPDS) demonstrated a continued reduction in microvascular risk (-24%, p = 0.001) and emergent risk reductions for myocardial infarction (-15%, p = 0.01) and death from any cause (-13%, p = 0.007), despite an early loss of glycaemic differences ("legacy effect"). A continued benefit after metformin therapy was evident during the ten-year post-trial follow-up among overweight patients (-33%, p = 0.005 for myocardial infarction and -27%, p = 0.002 for death from any cause). In contrast, the benefits of previously improved blood pressure control were not sustained when between-groups differences in blood pressure were lost during follow-up, except for a reduced risk for peripheral vascular disease. These observations are strong arguments in favour of an early optimisation of blood glucose control and of a sustained control of blood pressure in patients with type 2 diabetes. [less ▲]

Detailed reference viewed: 171 (5 ULg)
Full Text
Peer Reviewed
See detailSelf-reflection across time: cortical midline structures differentiate between present and past selves
D'Argembeau, Arnaud ULg; Feyers, Dorothée ULg; Majerus, Steve ULg et al

in Social Cognitive and Affective Neuroscience (2008), 3(3), 244-252

The processing of personal changes across time and the ability to differentiate between representations of present and past selves are crucial for developing a mature sense of identity. In this study, we ... [more ▼]

The processing of personal changes across time and the ability to differentiate between representations of present and past selves are crucial for developing a mature sense of identity. In this study, we explored the neural correlates of self-reflection across time using functional magnetic resonance imaging (fMRI). College undergraduates were asked to reflect on their own psychological characteristics and those of an intimate other, for both the present time period (i.e. at college) and a past time period (i.e. high school years) that involved significant personal changes. Cortical midline structures (CMS) were commonly recruited by the four reflective tasks (reflecting on the present self, past self, present other and past other), relative to a control condition (making valence judgments). More importantly, however, the degree of activity in CMS also varied significantly according to the target of reflection, with the ventral and dorsal medial prefrontal cortex and the posterior cingulate cortex being more recruited when reflecting on the present self than when reflecting on the past self or when reflecting on the other person. These findings suggest that CMS may contribute to differentiate between representations of present and past selves. [less ▲]

Detailed reference viewed: 75 (6 ULg)
Full Text
Peer Reviewed
See detailRemembering pride and shame: Self-enhancement and the phenomenology of autobiographical memory
D'Argembeau, Arnaud ULg; Van der Linden, Martial ULg

in Memory (2008), 16(5), 538-547

People's self-images are grounded in autobiographical memories and, in particular, in the phenomenological experience associated with remembering. The desire to increase or maintain the positivity of the ... [more ▼]

People's self-images are grounded in autobiographical memories and, in particular, in the phenomenological experience associated with remembering. The desire to increase or maintain the positivity of the self-image (i.e., the self-enhancement motive) might thus play an important role in shaping memory phenomenology. This study examined this hypothesis by asking participants to recall positive and negative events that involve self-evaluations (i.e., pride and shame) and positive and negative events that involve evaluations about others (i.e., admiration and contempt); various phenomenological characteristics (e.g., sensory details, feeling of re-experiencing) were assessed using rating scales. The results show a positivity bias (i.e., subjectively remembering positive events with more details than negative events) for events that involve self-evaluations but not for events that involve evaluations of others. In addition, this bias was stronger for people high in self-esteem. It is concluded that biases affecting the phenomenology of autobiographical memory are part of the arsenal of psychological mechanisms people use to maintain a positive self-image. [less ▲]

Detailed reference viewed: 143 (11 ULg)
Full Text
Peer Reviewed
See detailEmbodiment effects in memory for facial identity and facial expression
D'Argembeau, Arnaud ULg; Lepper, Miriam; Van der Linden, Martial ULg

in Cognition & Emotion (2008), 22

Research suggests that states of the body, such as postures, facial expressions, and arm movements, play central roles in social information processing. This study investigated the effects of approach ... [more ▼]

Research suggests that states of the body, such as postures, facial expressions, and arm movements, play central roles in social information processing. This study investigated the effects of approach/avoidance movements on memory for facial information. Faces displaying a happy or a sad expression were presented and participants were induced to perform either an approach (arm flexion) or an avoidance (arm extension) movement. States of awareness associated with memory for facial identity and memory for facial expression were then assessed with the Remember/Know/Guess paradigm. The results showed that performing avoidance movements increased Know responses for the identity, and Know/Guess responses for the expression, of valence-compatible stimuli (i.e., sad faces as compared to happy faces), whereas this was not the case for approach movements. Based on these findings, it is suggested that approach/avoidance motor actions influence memory encoding by increasing the ease of processing for valence-compatible information. [less ▲]

Detailed reference viewed: 94 (8 ULg)
Full Text
Peer Reviewed
See detailEndoprotheses coronaires pharmaco-actives chez les patients diabetiques.
Nyssen, Astrid; Legrand, Victor ULg; Scheen, André ULg

in Revue Médicale Suisse (2008), 4(168), 1806-10

In diabetic patients, the use of drug-eluting stents (paclitaxel-PES or sirolimus-SES) reduces the risk of restenosis as compared to bare-metal stents. However, the risk of (very) late thrombosis is ... [more ▼]

In diabetic patients, the use of drug-eluting stents (paclitaxel-PES or sirolimus-SES) reduces the risk of restenosis as compared to bare-metal stents. However, the risk of (very) late thrombosis is higher with drug-eluting stents than with bare-metal stents. All together, the incidence of major cardiovascular events is reduced with drug-eluting stents, mainly resulting from a diminution of revascularisation procedures rather than from a reduction in myocardial infarcts or cardiovascular deaths. Attempts to compare SES and PES gave discordant results in both randomised trials and registries. Efficacious antiplatelet therapy in the long run is mandatory in all diabetic patients treated with drug-eluting stents. [less ▲]

Detailed reference viewed: 38 (10 ULg)
Full Text
Peer Reviewed
See detailQuelle place pour une double ou triple inhibition du systeme renine-angiotensine-aldosterone ?
Legrand, Delphine ULg; Krzesinski, Jean-Marie ULg; Scheen, André ULg

in Revue Médicale Suisse (2008), 4(168), 1792-7

The blockade of the renin-angiotensin-aldosterone system (RAAS) is helpful in the management of arterial hypertension, congestive heart failure, post-myocardial infarction and diabetic nephropathy. Such ... [more ▼]

The blockade of the renin-angiotensin-aldosterone system (RAAS) is helpful in the management of arterial hypertension, congestive heart failure, post-myocardial infarction and diabetic nephropathy. Such blockade can be obtained with an angiotensin converting enzyme inhibitor, a specific antagonist of angiotensin II AT1 receptors, an aldosterone receptor antagonist and/or a direct inhibitor of renin such as aliskiren. Various studies have demonstrated that a dual or even triple RAAS inhibition may offer a better cardiorenal protection, in refractory congestive heart failure and in nephropathy with proteinuria. However, in the ONTARGET study, the dual inhibition with ramipril plus telmisartan did not provide any additional benefit compared to ramipril alone in high-risk cardiovascular patients, but showed a worse tolerance profile. [less ▲]

Detailed reference viewed: 67 (9 ULg)
Full Text
Peer Reviewed
See detailRisque anesthesique lie a une neuropathie autonome cardiaque chez le patient diabetique.
Van Cauwenberge, Isabelle ULg; Philips, Jean-Christophe ULg; Scheen, André ULg

in Revue Médicale de Liège (2008), 63(7-8), 488-93

Cardiac autonomic neuropathy is an underestimated complication among diabetic patients. It affects both the sympathetic and parasympathetic systems and is often associated with other, autonomic or not ... [more ▼]

Cardiac autonomic neuropathy is an underestimated complication among diabetic patients. It affects both the sympathetic and parasympathetic systems and is often associated with other, autonomic or not, complications, which make the patient even more frail. Some autonomic clinical manifestations have a direct impact on perioperative morbidity and mortality. The most important ones consist in haemodynamic instability, rhythmic disorders, mainly related to increased QT interval, and finally a higher risk of cardiorespiratory arrest. Recommendations are proposed before, during and after surgery to reduce the incidence of these complications in high risk patients. A screening for autonomic neuropathy may be helpful to improve the management of patients with diabetes who undergo surgery requiring general anaesthesia. [less ▲]

Detailed reference viewed: 268 (11 ULg)
Full Text
Peer Reviewed
See detailTransmission of lymphoma via organ transplantation
Detry, Olivier ULg

in American Journal of Transplantation (2008), 8

Detailed reference viewed: 45 (21 ULg)
Full Text
Peer Reviewed
See detailEffect of rimonabant on blood pressure in overweight/obese patients with/without co-morbidities: analysis of pooled RIO study results.
Ruilope, Luis M; Despres, Jean-Pierre; Scheen, André ULg et al

in Journal of Hypertension (2008), 26(2), 357-67

OBJECTIVE: Rimonabant, the first selective cannabinoid type 1 (CB1) receptor blocker, has been shown to improve multiple cardiometabolic risk factors in overweight/obese patients. This analysis assessed ... [more ▼]

OBJECTIVE: Rimonabant, the first selective cannabinoid type 1 (CB1) receptor blocker, has been shown to improve multiple cardiometabolic risk factors in overweight/obese patients. This analysis assessed the impact of rimonabant on blood pressure in the pooled population from four large trials with similar design - the Rimonabant-In-Obesity (RIO) programme. METHODS: RIO-Europe (n = 1507) and RIO-North America (n = 3040) recruited overweight/obese patients, and RIO-Lipids (n = 1033) and RIO-Diabetes (n = 1045) recruited overweight/obese patients with untreated dyslipidaemia or type 2 diabetes, respectively. At study entry (screening), 37.2% (n = 2463) of patients had hypertension, 71.4% (n = 1757) of whom were taking an antihypertensive treatment. RESULTS: After 1 year of treatment, mean change in systolic blood pressure (SBP) from baseline was -0.8 mmHg for rimonabant 20 mg versus +0.3 mmHg for placebo (P = 0.007); diastolic blood pressure (DBP) decreased by -0.8 versus -0.3 mmHg (P = 0.029) respectively. In the subgroup of patients with high blood pressure at baseline, SBP change was -7.5 mmHg for rimonabant 20 mg versus -4.7 mmHg for placebo (P = 0.005); DBP change was -5.2 versus -3.0 mmHg (P < 0.001). Reductions were more pronounced in patients with dyslipidaemia and type 2 diabetes. There was no effect of rimonabant 20 mg on blood pressure beyond that expected from weight loss alone. Overall, there was a similar incidence of adverse events (AEs) at 1 year in the placebo (81.8%) and rimonabant 20 mg (86.0%). The most common AEs occurring with rimonabant were nausea, dizziness, arthralgia and diarrhoea. A slightly higher proportion of patients in the rimonabant 20 mg group discontinued as a result of AEs (13.8%) versus placebo (7.2%). CONCLUSIONS: Rimonabant 20 mg led to modest, but significant SBP and DBP reductions in overweight/obese patients. The effect of rimonabant on blood pressure appears to be mediated by weight loss. [less ▲]

Detailed reference viewed: 78 (1 ULg)
Full Text
Peer Reviewed
See detailStem cell factor and mesenchymal and neural stem cell transplantation in a rat model of Huntington's disease.
Bantubungi, Kadiombo; Blum, David; Cuvelier, Laetitia et al

in Molecular & Cellular Neuroscience [=MCN] (2008), 37(3), 454-70

Neural and mesenchymal stem cells have been proposed as alternative sources of cells for transplantation into the brain in neurodegenerative disorders. However, the endogenous factors controlling their ... [more ▼]

Neural and mesenchymal stem cells have been proposed as alternative sources of cells for transplantation into the brain in neurodegenerative disorders. However, the endogenous factors controlling their engraftment within the injured parenchyma remain ill-defined. Here, we demonstrate significant engraftment of undifferentiated exogenous mesenchymal or neural stem cells throughout the lesioned area in a rat model for Huntington's disease, as late as 8 weeks post-transplantation. We show that stem cell factor (SCF), strongly up-regulated within host cells in the damaged striatum, is able to activate the SCF receptor c-kit and its signaling pathway and to promote the migration and proliferation of mesenchymal and neural stem cells in vitro. Furthermore, c-kit receptor blockade alters neural stem cell distribution within the lesioned striatum. Host SCF expression is observed in atypical cells expressing glial fibrillary acidic protein and doublecortin in the lesioned striatum and in migrating doublecortin-positive progenitors. Taken together, these data demonstrate that SCF produced in situ in the lesioned striatum is an important factor in promoting the engraftment of stem cells within the lesioned brain. [less ▲]

Detailed reference viewed: 121 (7 ULg)