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See detailMidsagittal Jaw Movement Analysis for the Scoring of Sleep Apneas and Hypopneas
Senny, Frédéric ULg; Destiné, Jacques ULg; Poirrier, Robert ULg

in IEEE Transactions on Biomedical Engineering (2008), 55(1), 87-95

Given the importance of the detection and classification of sleep apneas and hypopneas (SAHs) in the diagnosis and the characterization of the SAH syndrome, there is a need for a reliable noninvasive ... [more ▼]

Given the importance of the detection and classification of sleep apneas and hypopneas (SAHs) in the diagnosis and the characterization of the SAH syndrome, there is a need for a reliable noninvasive technique measuring respiratory effort. This paper proposes a new method for the scoring of SAHs based on the recording of the midsagittal jaw motion (MJM, mouth opening) and on a dedicated automatic analysis of this signal. Continuous wavelet transform is used to quantize respiratory effort from the jaw motion, to detect salient mandibular movements related to SAHs and to delineate events which are likely to contain the respiratory events. The classification of the delimited events is performed using multilayer perceptrons which were trained and tested on sleep data from 34 recordings. Compared with SAHs scored manually by an expert, the sensitivity and specificity of the detection were 86.1% and 87.4%, respectively. Moreover, the overall classification agreement in the recognition of obstructive, central, and mixed respiratory events between the manual and automatic scorings was 73.1%. The MJM signal is hence a reliable marker of respiratory effort and allows an accurate detection and classification of SAHs. [less ▲]

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See detailThe Hazar pull-apart along the East Anatolian Fault: Structure and active deformation
Hubert, Aurelia ULg; Garcia, D; Moernaut, J et al

Conference (2008, January)

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See detailHerbe, diguettes, pesticides et pomme de terre
Maugnard, Alexandre; Bodson, Bernard ULg; Goffart, Jean-Pierre et al

in Phytoma : La Défense des Végétaux (2008), 611

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See detailLes landes et pelouses sur sable du Brabant sablo-limoneux (Deuxième partie)
Taymans, Julien ULg; Mahy, Grégory ULg

in Parcs & Réserves (2008), 62(4), 4-12

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See detailEvidence for a Role of Early Oestrogens in the Central Processing of Sexually Relevant Olfactory Cues in Female Mice
Pierman, S.; Douhard, Quentin ULg; Bakker, Julie ULg

in European Journal of Neuroscience (2008), 27(2), 423-31

We previously found that female aromatase knockout (ArKO) mice showed less investigation of socially relevant odours as well as reduced sexual behaviour. We now ask whether these behavioural deficits ... [more ▼]

We previously found that female aromatase knockout (ArKO) mice showed less investigation of socially relevant odours as well as reduced sexual behaviour. We now ask whether these behavioural deficits might be due to an inadequate processing of odours in female ArKO mice. Therefore, we exposed female ArKO mice to same- and opposite-sex urinary odours and determined the expression of the immediate early gene c-Fos along the main and accessory olfactory projection pathways. We included ArKO males in the present study as we previously observed that they show female-typical detection thresholds of urinary odours, suggesting a role for perinatal oestrogens in these behavioural responses. No sex or genotype differences were observed in the olfactory bulb after urine exposure. By contrast, sex differences in c-Fos responses were observed in wild-type (WT) mice following exposure to male urine in the more central regions of the olfactory pathway; only WT females showed a significant Fos induction in the amygdala, central medial pre-optic area and ventromedial hypothalamus. However, ArKO females did not show a c-Fos response to male odours in the ventromedial hypothalamus, suggesting that the processing of male odours is affected in ArKO females and thus that oestrogens may be necessary for the development of neural responses to sexually relevant odours in female mice. By contrast, c-Fos responses to either male or oestrous female urine were very similar between ArKO and WT males, pointing to a central role of androgen vs. oestrogen signalling in the male circuits that control olfactory investigation and preferences. [less ▲]

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See detail(19) F NMR in vivo spectroscopy reflects the effectiveness of perfusion - enhancing vascular modifiers for improving gemcitabine chemotheraypy
Cron, Greg O.; Ansiaux; MARTINIVE, Philippe ULg et al

in Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine (2008)

Laboratory of Biomedical Magnetic Resonance and Laboratory of Medicinal Chemistry and Radiopharmacy, Université Catholique de Louvain, UCL, Brussels, Belgium. Nuclear magnetic resonance spectroscopy of ... [more ▼]

Laboratory of Biomedical Magnetic Resonance and Laboratory of Medicinal Chemistry and Radiopharmacy, Université Catholique de Louvain, UCL, Brussels, Belgium. Nuclear magnetic resonance spectroscopy of fluorine-19 ((19)F NMR) has proven useful for evaluating kinetics of fluorinated chemotherapy drugs in tumors in vivo. This work investigated how three perfusion-enhancing vascular modifiers (BQ123, thalidomide, and Botulinum neurotoxin type A [BoNT-A]) would affect the chemotherapeutic efficacy of gemcitabine, a fluorinated drug widely used in human cancer treatment. Murine tumor growth experiments demonstrated that only BoNT-A showed a strong trend to enhance tumor growth inhibition by gemcitabine (1.7 days growth delay, P = 0.052, Student t-test). In accord with these results, (19)F NMR experiments showed that only BoNT-A increased significantly the uptake of gemcitabine in tumors (50% increase, P = 0.0008, Student t-test). Further experiments on gemcitabine kinetics (NMR vs time) and distribution ((19)F MRI) confirmed the uptake-enhancing properties of BoNT-A. The results of this study demonstrate that (19)F NMR can monitor modulation of the pharmacokinetics of fluorinated chemotherapy drugs in tumors. The results also show that (19)F NMR data can give a strong indication of the effectiveness of perfusion-enhancing vascular modifiers for improving gemcitabine chemotherapy in murine tumors. (19)F NMR is a promising tool for preclinical evaluation of such vascular modifiers and may ultimately be used in the clinic to monitor how these modifiers affect chemotherapy. 2007 Wiley-Liss, Inc PMID: 18050344 [PubMed - indexed for MEDLINE] [less ▲]

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See detailLe pousse-pousse à gougouttes
Terwagne, Denis ULg; Eddi, Antonin; Fort, Emmanuel et al

Conference (2008, January)

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See detailBreeding sites of bluetongue vectors in northern Europe
Zimmer, Jean-Yves ULg; Haubruge, Eric ULg; Francis, Frédéric ULg et al

in Veterinary Record : Journal of the British Veterinary Association (2008), 162(4), 131

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See detailRole for Estradiol in Female-Typical Brain and Behavioral Sexual Differentiation
Bakker, Julie ULg; Baum, M. J.

in Frontiers in Neuroendocrinology (2008), 29(1), 1-16

The importance of estrogens in controlling brain and behavioral sexual differentiation in female rodents is an unresolved issue in the field of behavioral neuroendocrinology. Whereas, the current dogma ... [more ▼]

The importance of estrogens in controlling brain and behavioral sexual differentiation in female rodents is an unresolved issue in the field of behavioral neuroendocrinology. Whereas, the current dogma states that the female brain develops independently of estradiol, many studies have hinted at possible roles of estrogen in female sexual differentiation. Accordingly, it has been proposed that alpha-fetoprotein, a fetal plasma protein that binds estrogens with high affinity, has more than a neuroprotective role and specifically delivers estrogens to target brain cells to ensure female differentiation. Here, we review new results obtained in aromatase and alpha-fetoprotein knockout mice showing that estrogens can have both feminizing and defeminizing effects on the developing neural mechanisms that control sexual behavior. We propose that the defeminizing action of estradiol normally occurs prenatally in males and is avoided in fetal females because of the protective actions of alpha-fetoprotein, whereas the feminizing action of estradiol normally occurs postnatally in genetic females. [less ▲]

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See detailL'Image du mois. L'acide 5-Amino-Levulinique (5-ALA) dans le traitement des tumeurs cérébrales malignes
Luckers, O.; James, S.; Ghassempour, K. et al

in Revue Médicale de Liège (2008), 63(1), 4-5

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See detailContribution à la compréhension du fonctionnement hydrogeologique du système aquifère dans le bassin du Kou (Burkina Faso)
Sauret, Elie ULg

Master of advanced studies dissertation (2008)

Located at the South of the town of Dioulasso sore, economic capital of Burkina Faso, the basin of the Kou consists of sandy, carbonated and clayed formations dated from the Precambrian one. These ... [more ▼]

Located at the South of the town of Dioulasso sore, economic capital of Burkina Faso, the basin of the Kou consists of sandy, carbonated and clayed formations dated from the Precambrian one. These formations constitute materials of four aquifers formations whose geometrical characteristics and the interactions with the rivers and the important sources of Nasso (10.000 m3/h) and Pésso (600 m3/h) remain complex and badly known. In order to provide a better comprehension of the hydrogeology of this vast basin of 1860 km2, the present study was initiated. For the needs for the study, the limits of the Kou basin were extended to its natural borders: the Mouhoun river in North-Western and the cliff of Banfora in the South-East. The four aquifers formations considered as a single hydrogeological unit, were modelled considering steady state groundwater flow conditions. Modeling made it possible to understand the interactions groundwater -water of surface by quantifying exchanged water flows. The results provided by this model appear acceptable in comparison of the allowed assumptions, and the data we have used. [less ▲]

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See detailSurgical correction of ischaemic mitral regurgitation - still a long way to go
Kolh, Philippe ULg

in European Heart Journal (2008), 29

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See detailAnalgésie par blocs nerveux périphériques continus dans le cadre des soins de plaies cutanées
Lecoq, Jean-Pierre; Jacquemin, Denise ULg; Lamy, Maurice ULg et al

in Revue Médicale de Liège (2008), 63(1), 3-16

We present the case of a patient with a circumferential venous ulcer at the level of the calf. She is hospitalized for surgical treatment by continuous aspiration dressing and coverage with skin graft ... [more ▼]

We present the case of a patient with a circumferential venous ulcer at the level of the calf. She is hospitalized for surgical treatment by continuous aspiration dressing and coverage with skin graft. This patient presents a history of chronic pain, on which classical medications have few effects and are accompanied by side effects. After discussion with the patient, a double continuous peripheral nervous block (femoral and sciatic nerve) is set up to improve the tolerance to wound dressing. This technique presents favorable antalgic results. The indications and the different techniques of block performance (by electrostimulation or echo-guided) are described. The infectious risks related to the presence of catheter near cutaneous wounds are clarified according to recent data of literature. The relevance of these techniques in correlation with the development of chronic pain and on the trophicity of the wounds are also discussed. [less ▲]

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See detailGastroenterology - Clinical and genetic factors associated with sacroiliitis in Crohn's disease
Peeters, Harald; Cruyssen, Bert Vander; Mielants, Herman et al

in Journal of Gastroenterology and Hepatology (2008), 23(1), 132-137

Background and Aim: Radiographic sacroiliitis (SI), often asymptomatic, is considered the most frequent extra-intestinal manifestation (EIM) of Crohn's disease (CD). Data on the association of SI with ... [more ▼]

Background and Aim: Radiographic sacroiliitis (SI), often asymptomatic, is considered the most frequent extra-intestinal manifestation (EIM) of Crohn's disease (CD). Data on the association of SI with other clinical features of CD are limited. Association of SI with CARD15 polymorphisms has recently been suggested. In a multicenter study, we investigated the association of SI in CD patients with clinical phenotypes, other EIM and CARD15 polymorphisms. Methods: Radiographs of the sacroiliac joints were taken in 251 CD patients from three Belgian university hospitals and scored by two blinded rheumatologists. Clinical features were obtained from medical records. Forty-three percent of patients carried at least one CARD15 polymorphism. Results: Sacroiliitis, defined as the presence of at least grade 2 unilateral changes, was diagnosed in 65 of the 244 scorable radiographs (27%). Only 16 of these patients were previously diagnosed with ankylosing spondylitis (AS). HLA-B27 positivity was observed in 53% of patients with AS and 7% of patients with radiographic SI. In univariate and multivariate analysis, associations between the presence of SI and peripheral arthritis (P = 0.005) and between AS and uveitis (P = 0.005) were found. No associations with other recorded clinical features or with CARD15 polymorphisms were observed. Conclusion: We confirm the high prevalence of radiographic sacroiliitis in a multicenter CD cohort. Uveitis is only associated with AS whereas all patients with SI are more prone to develop peripheral arthritis during their disease course, suggesting similar pathogenetic mechanisms in the development of these EIM. The previously reported association between SI and CARD15 polymorphisms was not confirmed. [less ▲]

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See detailLes maladies vénériennes chez le cheval
Ponthier, Jérôme ULg; Deleuze, Stefan ULg

in sBs Magazine (2008)

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