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See detailRadiothérapie externe accélérée postopératoire des carcinomes épidermoïdes localement évolués de la sphère ORL : étude prospective de phase II
Zouhair, A; COUCKE, Philippe ULg; Azria, D. et al

in Bulletin du Cancer. Radiothérapie : Journal de la Société Française du Cancer : Organe de la Société Française de Radiothérapie Oncologique (2003), 7

Abstract Purpose. – To assess the feasibility and efficacy of accelerated postoperative radiation therapy (RT) in patients with squamous-cell carcinoma of the head and neck (SCCHN). Patients and methods ... [more ▼]

Abstract Purpose. – To assess the feasibility and efficacy of accelerated postoperative radiation therapy (RT) in patients with squamous-cell carcinoma of the head and neck (SCCHN). Patients and methods. – Between December 1997 and July 2001, 68 patients (male to female ratio: 52/16; median age: 60-years (range: 43–81) with pT1-pT4 and/or pN0-pN3 SCCHN (24 oropharynx, 19 oral cavity, 13 hypopharynx, 5 larynx, 3 unknown primary, 2 maxillary sinus, and 2 salivary gland) were included in this prospective study. Postoperative RT was indicated because extracapsular infiltration (ECI) * Auteur correspondant. Adresse e-mail : abderrahim.zouhair@chuv.hospvd.ch (A. Zouhair). Cancer/Radiothérapie 7 (2003) 231–236 www.elsevier.com/locate/canrad © 2003 Éditions scientifiques et médicales Elsevier SAS. Tous droits réservés. doi:10.1016/S1278-3218(03)00041-6 was observed in 20 (29%), positive surgical margins (PSM) in 20 (29%) or both in 23 patients (34%). Treatment consisted of external beam RT 66 Gy in 5 weeks and 3 days. Median follow-up was 15 months. Results. – According to CTC 2.0, acute morbidity was acceptable: grade 3 mucositis was observed in 15 (22%) patients, grade 3 dysphagia in 19 (28%) patients, grade 3 skin erythema in 21 (31%) patients with a median weight loss of 3.1 kg (range: 0–16). No grade 4 toxicity was observed. Median time to relapse was 13 months; we observed only three (4%) local and four (6%) regional relapses, whereas eight (12%) patients developed distant metastases without any evidence of locoregional recurrence. The 2 years overall-, disease-free survival, and actuarial locoregional control rates were 85, 73 and 83% respectively. Conclusion. – The reduction of the overall treatment time using postoperative accelerated RT with weekly concomitant boost (six fractions per week) is feasible with local control rates comparable to that of published data. Acute RT-related morbidity is acceptable. [less ▲]

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See detailRENO, a European Postmarket Surveillance Registry, confirms effectiveness of coronary brachytheraypy in routine clinical practice.
Coen, V; Serruys, P; Sauerwein, W et al

in International Journal of Radiation, Oncology, Biology, Physics (2003), 55(4), 1019-1026

Purpose: To assess, by a European registry trial, the clinical event rate in patients with discrete stenotic lesions of coronary arteries (de novo or restenotic) in single or multiple vessels (native or ... [more ▼]

Purpose: To assess, by a European registry trial, the clinical event rate in patients with discrete stenotic lesions of coronary arteries (de novo or restenotic) in single or multiple vessels (native or bypass grafts) treated with -radiation. Methods and Materials: Between April 1999 and September 2000, 1098 consecutive patients treated in 46 centers in Europe and the Middle East with the Novoste Beta-Cath System were included in Registry Novoste (RENO). Results: Six-month follow-up data were obtained for 1085 patients. Of 1174 target lesions, 94.1% were located in native vessels and 5.9% in a bypass graft; 17.7% were de novo lesions, 4.1% were restenotic, and 77.7% were in-stent restenotic lesions. Intravascular brachytherapy was technically successful in 95.9% of lesions. Multisegmental irradiation, using a manual pullback stepping maneuver to treat longer lesions, was used in 16.3% of the procedures. The in-hospital rate of major adverse cardiac events was 1.8%. At 6 months, the rate was 18.7%. Angiographic follow-up was available for 70.4% of the patients. Nonocclusive restenosis was seen in 18.8% and total occlusion in 5.7% of patients. A combined end point for late (30–180 days) definitive or suspected target vessel closure was reached in 5.4%, but with only 2% of clinical events. Multivariate analysis was performed for major adverse cardiac events and late thrombosis. Conclusion: Data obtained from the multicenter RENO registry study, derived from a large cohort of unselected consecutive patients, suggest that the good results of recent randomized controlled clinical trials can be replicated in routine clinical practice. © 2003 Elsevier Science Inc. [less ▲]

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See detailVariations at different spatial scales of Posidonia oceanica (L.) Delile beds; effects on the physico-chemical parameters of the sediment
Gobert, Sylvie ULg; Kyramarios, Michael; Lepoint, Gilles ULg et al

in Oceanologica Acta (2003), 26(2), 199-207

The biometric parameters (shoot density, length and width of leaves, leaf and epiphyte biomasses, leaf surface) of the P. oceanica meadow present a significant spatial variability at the mesoscale level ... [more ▼]

The biometric parameters (shoot density, length and width of leaves, leaf and epiphyte biomasses, leaf surface) of the P. oceanica meadow present a significant spatial variability at the mesoscale level (100 m2). All the parameters studied, excepting the number of leaves, decrease according to the depth. The horizontal spatial variations (centrifuge and centripetal distributions) reach a maximum in the shallower areas. The analysis of the microstructures (m2) of the meadow has not allowed a relationship to be established between the spatial variations of the biometric parameters and the environmental factors in the sediment (pH, water and organic matter content, red-ox potential, nutrient content). The heterogeneity of the meadow in the Revellata Bay quite probably results from the internal shoot and rhyzome growth dynamics. <br />On the other hand, it appears that the presence of the prairie modifies the physical-chemical characteristics of the sediment. In fact, the sandy patches present different physical-chemical characteristics: lower organic matter, different granulometric and much higher interstitial water nutrient levels, as well as a higher pH and oxydo-reduction potential. [less ▲]

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See detailHistory of solid organ transplantation at the University of Liege
Lejeune, Georges ULg; Limet, Raymond ULg; Meurisse, Michel ULg et al

in Acta Chirurgica Belgica (2003), 103(3 Sp. Iss. SI), 32-36

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See detailBibliographie matérielle et critique textuelle. À propos de l'édition de 1751 des Pensées philosophiques de Diderot
Droixhe, Daniel ULg

in Recherches sur Diderot et l'Encyclopédie (2003), 34

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See detailL’anabaptisme au Pays de Liège (1533-1593)
Donneau, Olivier ULg

in Annuaire d'Histoire Liégeoise (2003), 32

Study of the spread of the anabaptists movements in the ecclesiastical principality of Liège during the 16th Century.

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See detailClass II histone deacetylases: versatile regulators.
Verdin, Eric; Dequiedt, Franck ULg; Kasler, Herbert G

in Trends in Genetics (2003), 19(5), 286-93

Histone acetylation and deacetylation play essential roles in modifying chromatin structure and regulating gene expression in eukaryotes. Histone deacetylases (HDACs) catalyze the deacetylation of lysine ... [more ▼]

Histone acetylation and deacetylation play essential roles in modifying chromatin structure and regulating gene expression in eukaryotes. Histone deacetylases (HDACs) catalyze the deacetylation of lysine residues in the histone N-terminal tails and are found in large multiprotein complexes with transcriptional co-repressors. Human HDACs are grouped into three classes based on their similarity to known yeast factors: class I HDACs are similar to the yeast transcriptional repressor yRPD3, class II HDACs to yHDA1 and class III HDACs to ySIR2. In this review, we focus on the biology of class II HDACs. These newly discovered enzymes have been implicated as global regulators of gene expression during cell differentiation and development. We discuss their emerging biological functions and the molecular mechanisms by which they are regulated. [less ▲]

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See detailVariations sur l'appel des ordonnances 'sur référé'
Boularbah, Hakim ULg

in Imperat Lex - Liber amicorum Pierre Marchal (2003)

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See detailComedolysis by a lipohydroxyacid formulation in acne-prone subjects.
Uhoda, Emmanuelle ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in European Journal of Dermatology (2003), 13(1), 65-8

Post-summertime exacerbation of acne is not a rare event. This study was conducted to assess the preventive effect of a proprietary formulation containing 2-hydroxy-5-octanoyl benzoic acid on this ... [more ▼]

Post-summertime exacerbation of acne is not a rare event. This study was conducted to assess the preventive effect of a proprietary formulation containing 2-hydroxy-5-octanoyl benzoic acid on this environmental related disease. This compound is commonly called beta-lipohydroxyacid (LHA). Among a randomized group of 14 acne-prone women, 12 who developed cornified follicular plugs the end of summertime were treated by the LHA formulation twice daily for 2 weeks. Ten of 14 other women who presented the same skin condition remained untreated as controls. The comedolytic effect was assessed using non-invasive ultraviolet-light video recording combined with computerized image analysis. The cornified follicular plugs were progressively cleared in 10/12 LHA-treated women and in 3/10 untreated volunteers. Analytical assessments showed a significant decrease in both the number and total size of microcomedones in the LHA-treated women. By contrast, no quantitative change was disclosed in the untreated group. It is concluded that the tested LHA formulation exerts comedolytic properties that might help in preventing post-summertime acne exacerbations. [less ▲]

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See detailLa guerre et la médecine d'une culture de paix. 3- Synopsis des armes chimiques.
Pierard, Gérald ULg

in FALCO (2003), Janvier

A variety of chemical components can be used as warfare threats directly targeting humans. They can be classified according to their main biological effects as nerve agents, vesicants, lung damaging ... [more ▼]

A variety of chemical components can be used as warfare threats directly targeting humans. They can be classified according to their main biological effects as nerve agents, vesicants, lung damaging agents, cyanogen agents and incapacitants. Other chemical agents are water and food contaminants. Sill other less aggressive compounds are mainly used to control riots. Smokes, flame materials and herbicides belong to other classes of chemical agents of the warlike armamentum exhibiting a direct effect on man. [less ▲]

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See detailRéactions cutanées indésirables aux antidépresseurs.
Braham, C.; Paquet, Philippe ULg; Pitchot, William ULg et al

in Revue Médicale de Liège (2003), 58(1), 22-4

Due to the widespread usage of antidepressants by the population, they represent a class of drugs which is at high risk for cutaneous side effects. The diversity in the clinical presentations is large ... [more ▼]

Due to the widespread usage of antidepressants by the population, they represent a class of drugs which is at high risk for cutaneous side effects. The diversity in the clinical presentations is large. The variability in their severity is large as well. Morbidity may be quite severe, but the vital prognosis is rarely affected. [less ▲]

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See detailComment je traite ... une dermatite seborrhéique.
Pierard, Claudine ULg; Arrese Estrada, Jorge ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2003), 58(2), 67-9

Seborrhoeic dermatitis results from a peculiar inflammatory reaction directed to yeasts of the genus Malassezia which are present at the skin surface. The current therapeutic strategies to control ... [more ▼]

Seborrhoeic dermatitis results from a peculiar inflammatory reaction directed to yeasts of the genus Malassezia which are present at the skin surface. The current therapeutic strategies to control episodes of the dermatitis target the yeasts, the host reaction or both. [less ▲]

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See detailRevue de l'épidémiologie de la maladie de Crohn en Europe
Piront, Patricia ULg; Belaiche, Jacques ULg; Louis, Edouard ULg

in Acta Endoscopica (2003), 33

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See detailPolitique de la qualité ou défense de l’agriculture wallonne
Burny, Philippe ULg; Winandy, D.; Spoiden, G.

Article for general public (2003)

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See detailNMR structure of Citrobacter freundii AmpD, comparison with bacteriophage T7 lysozyme and homology with PGRP domains.
Liepinsh, Edvards; Genereux, Catherine ULg; Dehareng, Dominique ULg et al

in Journal of Molecular Biology (2003), 327(4), 833-42

AmpD is a bacterial amidase involved in the recycling of cell-wall fragments in Gram-negative bacteria. Inactivation of AmpD leads to derepression of beta-lactamase expression, presenting a major pathway ... [more ▼]

AmpD is a bacterial amidase involved in the recycling of cell-wall fragments in Gram-negative bacteria. Inactivation of AmpD leads to derepression of beta-lactamase expression, presenting a major pathway for the acquisition of constitutive antibiotic resistance. Here, we report the NMR structure of AmpD from Citrobacter freundii (PDB accession code 1J3G). A deep substrate-binding pocket explains the observed specificity for low molecular mass substrates. The fold is related to that of bacteriophage T7 lysozyme. Both proteins bind zinc at a conserved site and require zinc for amidase activity, although the enzymatic mechanism seems to differ in detail. The structure-based sequence alignment identifies conserved features that are also conserved in the eukaryotic peptidoglycan recognition protein (PGRP) domains, including the zinc-coordination site in several of them. PGRP domains thus belong to the same fold family and, where zinc-binding residues are conserved, may have amidase activity. This hypothesis is supported by the observation that human serum N-acetylmuramyl-L-alanine amidase seems to be identical with a soluble form of human PGRP-L. [less ▲]

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