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See detailPrédiction numérique des défauts de forme engendrés par l'usinage
Debongnie, Jean-François ULg; Masset, Luc ULg

in Actes du 7ème Congrès de Mécanique. Volume I. Mécanique des Solides (2005, April)

Presentation of a prediction method of form errors arising during machining which has been developed in the manufacturing laboratory of the University of Liège. It combines empirical force models and a ... [more ▼]

Presentation of a prediction method of form errors arising during machining which has been developed in the manufacturing laboratory of the University of Liège. It combines empirical force models and a finite element model of the machined part. A particularly efficient solution scheme has been developed, leading to a valuable tool for the industry. [less ▲]

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See detailA qualitative assessment of the influence of bioturbation in Lake Baikal sediments
Martin, Patrick; Boes, Xavier; Goddeeris, Baudouin et al

in Global and Planetary Change (2005), 46(1-4), 87-99

The impact of bioturbation in Lake Baikal sediments, particularly on rhythmic layering and mixing, was assessed by studying the actual vertical distribution of benthic animals in continuous accumulation ... [more ▼]

The impact of bioturbation in Lake Baikal sediments, particularly on rhythmic layering and mixing, was assessed by studying the actual vertical distribution of benthic animals in continuous accumulation zones selected by seismic survey (Vydrino, Shoulder, Posolskoe Bank, Continent Ridge). To assess the influence of the bioturbation, animals were extracted from short cores and identified at the relevant taxonomic level. The faunal distribution is examined in parallel with the bioturbation tracks observed in thin section. Oligochaeta, Nematoda, Ostracoda, Copepoda, Gammaridae, Chironomidae and Hydrachnidia were found inhabiting the sediment. Among them, only oligochaete worms were assumed to have a significant impact on sediment mixing because of their "conveyor belt" feeding. The other two most abundantly sampled groups, nematods and copepods, belong to the interstitial fauna that has no significant impact on the vertical displacement of sediment particles and do not ingest the sediment. The presence of a benthic fauna as deep as 15 cm in the sediment indicates that the possibility of sediment disturbance by invertebrate activity cannot be dismissed in Lake Baikal. The effect of biological mixing is more limited in the deepest stations because the number of potential bioturbators is reduced, qualitatively as well as quantitatively. Located in the abyssal zone, Continent and Vydrino (but outside turbidites) deep stations appear to be most promising sediment records for tracking climate signal at high resolution. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailEffect of a bovine colostrum supplementation in piglet diet at weaning on growth performances, food ingestion and faecal E. coli concentrations.
Boudry, Christelle ULg; Didderen, Isabelle; Wavreille, José et al

in Proceedings of the British Society of Animal Science (2005, April)

Bovine colostrum supplementation in piglets diet stimulates food intake and reduces the faecal E. coli population during the first week after weaning, inducing a liveweight gain increase. A reduction of ... [more ▼]

Bovine colostrum supplementation in piglets diet stimulates food intake and reduces the faecal E. coli population during the first week after weaning, inducing a liveweight gain increase. A reduction of the food conversion ratio was also observed, suggesting a better nutrient assimilation by the piglets. [less ▲]

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See detailProfile of soluble cytokine receptors in Crohn's disease
Gustot, T.; Lemmers, A.; Louis, Edouard ULg et al

in Gut (2005), 54(4), 488-495

Introduction: Soluble cytokine receptors (sCRs) modulate the in vivo activity of cytokines. Deficient sCR production could participate in the pathogenesis and course of Crohn's disease ( CD). The aim of ... [more ▼]

Introduction: Soluble cytokine receptors (sCRs) modulate the in vivo activity of cytokines. Deficient sCR production could participate in the pathogenesis and course of Crohn's disease ( CD). The aim of the study was to examine the profile of sCRs in CD patients and their modulation by infliximab and corticosteroids. Methods: We prospectively examined active CD patients (aCD) treated with either infliximab (n=21) or corticosteroids (n=9), CD patients in clinical remission (rCD, n=20), ulcerative colitis patients (UC, n=24), and healthy subjects (HS, n=15). Cultures of colonic biopsies were also examined from CD inflamed (n=8), CD non-inflamed (n=7), and healthy mucosa (n=8). Levels of tumour necrosis factor alpha (TNF-alpha), soluble TNF receptor I (sTNFRI), soluble TNF receptor II (sTNFRII), interleukin 1 beta (IL-1 beta), soluble IL-1 receptor I (sIL-1RI), soluble IL-1 receptor II (sIL-1RII), IL-6, soluble IL-6 receptor (sIL-6R), and sgp130 were measured using ELISA. Results: Higher levels of sTNFRI (p<0.05, p<0.01), sTNFRII (p<0.01, p<0.01), sIL-1RI (p<0.05, NS), IL-6 (p<0.01, p<0.01), and sIL-6R (p<0.05, NS) were observed in aCD compared with rCD and HS. Interestingly, sIL-1RII (p<0.05, p<0.01) and sgp130 (p<0.01, p<0.01) were profoundly decreased in aCD compared with rCD and HS, and were negatively correlated with CRP. Deficient production of sIL-1RII was specific to CD ( not observed in ulcerative colitis), and was further confirmed at the mucosal level. Infliximab decreased sTNFRII at one and four weeks (p<0.05) and enhanced sIL-6R levels at one week (p<0.05). Corticosteroids increased sIL-1RII levels at one week (p<0.05). Conclusion: CD is associated with dysregulated production of sCRs. Deficiency in sIL-1RII and sgp130 may be essential to CD pathogenesis. Their replacement through the use of fusion proteins could represent future alternative therapeutic strategies for CD. [less ▲]

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See detailGauche, droite et engagement public
Italiano, Patrick ULg; Deflandre, Dimitri; Jacquemain, Marc ULg

Conference (2005, April)

The paper examines poll survey data to see if the way people invest in public envolvement is different between thos consider themselves to the left and those who consider themselves to the right. It ... [more ▼]

The paper examines poll survey data to see if the way people invest in public envolvement is different between thos consider themselves to the left and those who consider themselves to the right. It appears that the difference beween rightl and left is small and that the main difference is bewteen those who choose a position and those who refuse to choose or do not answer. Rather interestingly, people that see themselves at the center ressembles strongly to non respondants, as if the center was a "refuge value". [less ▲]

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See detailExperimental validation of a diffusion equation-based modeling of the sound field in coupled rooms
Billon, Alexis ULg; Valeau, Vincent; Picaut, Judicaël et al

in Journal of the Acoustical Society of America (2005, April), 117(4), 2581-2581

Sound modeling in coupled rooms (i.e., two acoustically coupled rooms separated by an open area) has attracted considerable attention in the past. However accurate and operational models are still needed ... [more ▼]

Sound modeling in coupled rooms (i.e., two acoustically coupled rooms separated by an open area) has attracted considerable attention in the past. However accurate and operational models are still needed, principally when three or more rooms are coupled. In recent papers, a diffusion equation-based model has been applied to unusual room shapes. For the coupled rooms geometry, this diffusion model has been validated successfully by comparison with the classical statistical theory in a parametrical study of the coupling parameters [Billon et al., J. Acoust. Soc. Am. 116, 2553 (2004)]. In the present work, the diffusion model results are validated by means of a comparison with experimental results, both in terms of sound attenuation and reverberation time. A comparison is also provided with results given by the statistical theory and a ray tracing program. For this purpose, experiments have been conducted in two coupled classrooms with two different sound source locations. The results show a very good agreement between the diffusion model and the experiments. Conversely, the statistical model is not valid for modeling accurately the sound field distribution and decay in both coupled rooms. At last, the diffusion model runs much faster than the ray tracing program. [less ▲]

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See detailMallarmé : retour du même, presque autre
Durand, Pascal ULg

in Critique (2005), 695

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See detailInfluence de la température du fluide de soufflage sur le bruit de fente
Glesser, Martin; Billon, Alexis ULg; Valeau, Vincent et al

Conference (2005, April)

Les bouches de soufflage des systèmes de ventilation peuvent produire des sifflements de forte intensité. Pour étudier leur mécanisme de production un modèle expérimental où un jet rectangulaire heurte ... [more ▼]

Les bouches de soufflage des systèmes de ventilation peuvent produire des sifflements de forte intensité. Pour étudier leur mécanisme de production un modèle expérimental où un jet rectangulaire heurte une plaque fendue est étudié. Cette configuration donne naissance à un type de sons auto-entretenus connus sous le nom de bruit de fente. [less ▲]

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See detailAcidic extracellular pH induces matrix metalloproteinase-9 expression in mouse metastatic melanoma cells through the phospholipase D-mitogen-activated protein kinase signaling
Kato, Y.; Lambert, Charles ULg; Colige, Alain ULg et al

in Journal of Biological Chemistry (2005), 280(12), 10938-10944

The extracellular pH (pHe) of tumor tissues is often acidic, which can induce the expression of several proteins. We previously showed that production of matrix metalloproteinase-9 (MMP-9) was induced by ... [more ▼]

The extracellular pH (pHe) of tumor tissues is often acidic, which can induce the expression of several proteins. We previously showed that production of matrix metalloproteinase-9 (MMP-9) was induced by culturing cells at acidic pHe (5.4-6.5). Here we have investigated the signal transduction pathway by which acidic pHe induces MMP-9 expression. We found that acidic pHe (5.9) activated phospholipase D (PLD), and inhibition of PLD activity by 1-butanol and Myr-ARF6 suppressed the acidic pHe-induced MMP-9 expression. Exogenous PLD, but not phosphatidylinositol-specific PLC or PLA(2), mimicked MMP-9 induction by acidic pHe. Western blot analysis revealed that acidic pHe increased the steady-state levels of phosphorylated extracellular signal-regulated kinases 1/2 and p38 and that the PLD inhibitors suppressed these increases. Using 5'-deletion mutant constructs of the MMP-9 promoter, we found that the acidic pHe-responsive region was located at nucleotide -670 to -531, a region containing the NF kappa B binding site. A mutation into the NF kappa B binding site reduced, but not completely, the acidic pHe- induced MMP-9 promoter activity, pand NF kappa B activity was induced by acidic pHe. Pharmacological inhibitors specific for mitogen-activated protein kinase kinase 1/2 (PD098059) and p38 (SB203580) attenuated the acidic pHe- induced NF kappa B activity and MMP-9 expression. These data suggest that PLD, mitogen-activated protein kinases (extracellular signal-regulated kinases 1/2 and p38), and NF kappa B mediate the acidic pHe signaling to induce MMP-9 expression. A transcription factor(s) other than NF kappa B may also be involved in the MMP-9 expression. [less ▲]

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See detailInterférométrie destructive: du sol à l’espace
Absil, Olivier ULg

Scientific conference (2005, March 22)

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See detailGraft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning
Baron, Frédéric ULg; Maris, M. B.; Sandmaier, B. M. et al

in Journal of Clinical Oncology (2005), 23(9), 1993-2003

Purpose We have used a nonmyelorablative conditioning regimen consisting of total-body irradiation (2 Gy) with or without fludarabine (30 mg/m(2)/d for 3 days) for related and unrelated hematopoietic cell ... [more ▼]

Purpose We have used a nonmyelorablative conditioning regimen consisting of total-body irradiation (2 Gy) with or without fludarabine (30 mg/m(2)/d for 3 days) for related and unrelated hematopoietic cell transplantation (HCT) in patients with hematologic malignancies who were not candidates for conventional HCT because of age, medical comorbidities, or preceding high-dose HCT. This approach relied on graft-versus-tumor (GVT) effects for control of malignancy. Patients and Methods We analyzed GVT effects in 322 patients given grafts from HILA-matched related (n = 192) or unrelated donors (n = 130). Results Of the 221 patients with measurable disease at HCT, 126 (57%) achieved complete (n = 98) or partial (n = 28) remissions. In multivariate analysis, there was a higher probability trend of achieving complete remissions in patients with chronic extensive graft-versus-host disease (GVHD, P = .07). One hundred eight patients (34%) relapsed or progressed. In multivariate analysis, achievement of full donor chimerism was associated with a decreased risk of relapse or progression (P = .002). Grade 2 to 4 acute GVHD had no significant impact on the risk of relapse or progression but was associated with increased risk of nonrelapse mortality and decreased probability of progression-free survival (PFS). Conversely, extensive chronic GVHD was associated with decreased risk of relapse or progression (P = .006) and increased probability of PFS (P = .003). Conclusion New approaches aimed at reducing the incidence of grade 2 to 4 acute GVHD might improve survival after allogeneic HCT after nonmyeloablative conditioning. (c) 2005 by American Society of Clinical Oncology. [less ▲]

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See detailNaître pour disparaître
Van Caillie, Didier ULg

Article for general public (2005)

This vulgarisation paper highlights why so many young firms are almost immediately conducted to business failure. It insists on the problem of under-capitalisation as a key indicator of business failure ... [more ▼]

This vulgarisation paper highlights why so many young firms are almost immediately conducted to business failure. It insists on the problem of under-capitalisation as a key indicator of business failure amongst young firms. [less ▲]

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See detailSa passion : la liberté
Cormann, Grégory ULg

Article for general public (2005)

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See detailInfluence of the nature of the electrolyte on the chiral separation of basic compounds in nonaqueous capillary electrophoresis using heptakis(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin
Servais, Anne-Catherine ULg; Fillet, Marianne ULg; Chiap, Patrice ULg et al

in Journal of Chromatography. A (2005), 1068(1), 143-150

The influence on the enantiomeric resolution of the nature of the cationic BGE component (sodium, ammonium or potassium) and that of the anionic component (chloride, formate, methanesulfonate or ... [more ▼]

The influence on the enantiomeric resolution of the nature of the cationic BGE component (sodium, ammonium or potassium) and that of the anionic component (chloride, formate, methanesulfonate or camphorsulfonate) as well as the concentration of heptakis(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin (HDMS-beta-CD), the selected chiral selector, was studied in nonaqueous capillary electrophoresis (NACE). For this purpose, two D-optimal designs with 33 and 26 experimental points were applied. Three beta-blockers (atenolol, celiprolol and propranolol) and three local anesthetics (bupivacaine, mepivacaine and prilocaine) were selected as basic model compounds. Both cationic and anionic BGE components were found to have a deep impact on the enantiomeric resolution of the investigated analytes but it is the cationic component that has shown the strongest influence. Indeed, in some cases, the change of the latter led to a complete loss of enantioresolution. Based on the observed results, two NACE systems were recommended, namely ammonium formate and potassium camphorsulfonate in a methanolic solution containing HDMS-beta-CD and acidified with formic acid, in order to separate efficiently the enantiomers of basic drugs. (c) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailThe massive runaway stars HD 14633 and HD 15137
Boyajian, T. S.; Beaulieu, T. D.; Gies, D. R. et al

in Astrophysical Journal (2005), 621(2, Part 1), 978-984

We present results from a radial velocity study of two runaway O-type stars, HD14633 (ON8.5V) and HD 15137 [O9.5 III(n)]. We find that HD 14633 is a single-lined spectroscopic binary with an orbital ... [more ▼]

We present results from a radial velocity study of two runaway O-type stars, HD14633 (ON8.5V) and HD 15137 [O9.5 III(n)]. We find that HD 14633 is a single-lined spectroscopic binary with an orbital period of 15.4083 days. The second target, HD 15137, is a radial velocity variable and a possible single-lined spectroscopic binary with a period close to 1 month. Both binaries have large eccentricity, small semiamplitude, and a small mass function. We show the trajectories of the stars in the sky based on an integration of motion in the Galactic potential, and we suggest that both stars were ejected from the vicinity of the open cluster NGC 654 in the Perseus spiral arm. The binary orbital parameters and runaway velocities are consistent with the idea that both these stars were ejected by supernova explosions in binaries and that they host neutron star companions. We find that the time of flight since ejection is longer than the predicted evolutionary timescales for the stars. This discrepancy may indicate that the stars have a lower mass than normally associated with their spectral classifications, that they were rejuvenated by mass transfer prior to the supernova, or that their lives have been extended through rapid rotation. [less ▲]

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See detailAutomated method for the determination of a new matrix metalloproteinase inhibitor in ovine plasma and serum by coupling of restricted access material for on-line sample clean-up to liquid chromatography
Chiap, Patrice ULg; Piette, Marie ULg; Evrard, Brigitte ULg et al

in Journal of Chromatography. B : Analytical Technologies in the Biomedical & Life Sciences (2005), 817(1), 109-117

A fully automated liquid chromatographic method was developed for the determination of Ro 28-2653, a new synthetic inhibitor of matrix metalloproteinases (MMPs), in ovine serum and plasma. The method was ... [more ▼]

A fully automated liquid chromatographic method was developed for the determination of Ro 28-2653, a new synthetic inhibitor of matrix metalloproteinases (MMPs), in ovine serum and plasma. The method was based on the coupling of a pre-column packed with restricted access material, namely LiChrospher RP-8 ADS (alkyl diol silica), for sample clean-up to an analytical column containing octyl silica stationary phase. One hundred mul of biological sample, to which 2-propanol was automatically added, were injected onto the ADS pre-column, which was then washed with a washing liquid consisting of a mixture of 25 mM phosphate buffer (pH 7.0) and acetonitrile (90: 10; v/v) for 10 min. By rotation of the switching valve, the analyte was then eluted in the back-flush mode with the LC mobile phase composed of a mixture of acetonitrile and 25 mM phosphate buffer (pH 7.0) (57:43; v/v). The UV detection was performed at 395 nm. The main parameters likely to influence the sample preparation technique were investigated. The method was then validated over a concentration range from 17.5 to 1950 ng/mI, the first concentration level corresponding to the lower limit of quantitation. At this concentration level, the mean bias and the R.S.D. value for intermediate precision were -2.4% and 4.2%, respectively. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailLow daunomycin concentrations protect colorectal cancer cells from hypoxia-induced apoptosis
Lechanteur, Chantal ULg; Jacobs, Nathalie ULg; Greimers, Roland ULg et al

in Oncogene (2005), 24(10), 1788-1793

Hypoxia, a common feature of solid tumors, is a direct stress that triggers apoptosis in many cell types. Poor or irregular tumor vascularization also leads to a decreased drug diffusion and cancer cells ... [more ▼]

Hypoxia, a common feature of solid tumors, is a direct stress that triggers apoptosis in many cell types. Poor or irregular tumor vascularization also leads to a decreased drug diffusion and cancer cells distant from blood vessels (hypoxic cells) are exposed to low drug concentrations. In this report, we show that low daunomycin concentrations protect HCT116 colorectal cancer cells from hypoxia-induced apoptosis. While hypoxia induced p53 accumulation without expression of its responsive genes (bax and p21), daunomycin treatment restored p53 transactivation activity and cell cycle progression. We also demonstrated a role for Akt activation in daunomycin-induced protection through phosphorylation and inactivation of the Bcl-2 family proapoptotic factor Bad. Our data therefore suggest that chemotherapy could possibly, because of low concentrations in poorly vascularized tumors, protect cancer cells from hypoxia-induced cytotoxicity. [less ▲]

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See detailIsotopic abundance of nitrogen and carbon in distant comets
Manfroid, Jean ULg; Jehin, Emmanuel ULg; Hutsemekers, Damien ULg et al

in Astronomy and Astrophysics (2005), 432(Letters), 5-8

The [SUP]12[/SUP]C[SUP]14[/SUP]N/[SUP]12[/SUP]C[SUP]15[/SUP]N and [SUP]12[/SUP]C[SUP]14[/SUP]N/[SUP]13[/SUP]C[SUP]14[/SUP]N isotopic ratios have been determined in comets C/1995 O1 (Hale-Bopp), C/2001 Q4 ... [more ▼]

The [SUP]12[/SUP]C[SUP]14[/SUP]N/[SUP]12[/SUP]C[SUP]15[/SUP]N and [SUP]12[/SUP]C[SUP]14[/SUP]N/[SUP]13[/SUP]C[SUP]14[/SUP]N isotopic ratios have been determined in comets C/1995 O1 (Hale-Bopp), C/2001 Q4 (NEAT) and C/2003 K4 (LINEAR) at heliocentric distances of, respectively, 2.7, 3.7 and 2.6 AU. These ratios have also been measured at rË 1 AU. No significant differences were found between all determinations, nor with the value obtained for other comets. If confirmed, the discrepancy between the nitrogen isotopic ratios from optical and millimeter measurements on CN and HCN would rule out HCN as a major parent of the cometary CN radicals. Based on observations collected at the European Southern Observatory, Paranal, Chile (ESO Programmes 270.C-5043, 073.C-0525 and 274.C-5015). [less ▲]

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