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See detailCarte hydrogéologique de Wallonie 1/25000 71/5-6 Lamorteau-Ruette.
Bouezmarni, Mohamed ULg; Denne, Pierre; Debbaut, Vincent ULg

Cartographic material (2009)

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See detailShifting Towards Environment-Friendly Modes: Profiling Travelers using Q-Methodology
Cools, Mario ULg; Moons, Elke; Janssens, Brecht et al

in Transportation (2009), 36(4), 437-453

Due to a variety of reasons, the previous century is characterized by an extraordinary growth in car use that has continued into the current century. This has resulted in serious environmental ... [more ▼]

Due to a variety of reasons, the previous century is characterized by an extraordinary growth in car use that has continued into the current century. This has resulted in serious environmental repercussions. Despite technological advancements, the externalities remain an ecological threat that can not be discarded by policy makers. Therefore, it is essential that policy makers focus on reducing car use and on stimulating the shift towards more environment-friendly transport modes. In this study, Q-methodology is adopted as the technique to segment people, and to ascertain which approaches and determinants matter to medium distance travel. Segmentation is important, as policy measures will be more efficient and effective if they are fine-tuned on specific target groups. The analysis revealed that four discourses preponderate the paradigm of environmentally sustainable transport: travelers who use public transport as a dominant alternative, car-dependent travelers, travelers with a positive perception of using public transport, and travelers with a preference for car use. Concerning rational, economic motives, individuals evaluate travel time reliability as most important. To increase the reliability policy makers should consider the use of separate bus lanes and traffic light manipulation. In addition, public transport can be made even more attractive, when costs of cars are made more variable by road or congestion charging. When the s motives are discussed, the differences between the different groups of travelers were more pronounced. Next to increasing the benefits of using public transport, policy makers should also pay attention to removing psycho-social barriers. [less ▲]

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See detailSynergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection
Reuse, sophie; Calao, Miriam; Kabeya, Kabamba et al

in PLoS ONE (2009), 4(6), 6093

The persistence of transcriptionally silent but replication-competent HIV-1 reservoirs in Highly Active Anti-Retroviral Therapy (HAART)-treated infected individuals, represents a major hurdle to virus ... [more ▼]

The persistence of transcriptionally silent but replication-competent HIV-1 reservoirs in Highly Active Anti-Retroviral Therapy (HAART)-treated infected individuals, represents a major hurdle to virus eradication. Activation of HIV-1 gene expression in these cells together with an efficient HAART has been proposed as an adjuvant therapy aimed at decreasing the pool of latent viral reservoirs. Using the latently-infected U1 monocytic cell line and latently-infected J-Lat T-cell clones, we here demonstrated a strong synergistic activation of HIV-1 production by clinically used histone deacetylase inhibitors (HDACIs) combined with prostratin, a non-tumor-promoting nuclear factor (NF)- kappaB inducer. In J-Lat cells, we showed that this synergism was due, at least partially, to the synergistic recruitment of unresponsive cells into the expressing cell population. A combination of prostratin+HDACI synergistically activated the 5' Long Terminal Repeat (5'LTR) from HIV-1 Major group subtypes representing the most prevalent viral genetic forms, as shown by transient transfection reporter assays. Mechanistically, HDACIs increased prostratin-induced DNA-binding activity of nuclear NF-kappaB and degradation of cytoplasmic NF-kappaB inhibitor, IkappaBalpha . Moreover, the combined treatment prostratin+HDACI caused a more pronounced nucleosomal remodeling in the U1 viral promoter region than the treatments with the compounds alone. This more pronounced remodeling correlated with a synergistic reactivation of HIV-1 transcription following the combined treatment prostratin+HDACI, as demonstrated by measuring recruitment of RNA polymerase II to the 5'LTR and both initiated and elongated transcripts. The physiological relevance of the prostratin+HDACI synergism was shown in CD8(+)-depleted peripheral blood mononuclear cells from HAART-treated patients with undetectable viral load. Moreover, this combined treatment reactivated viral replication in resting CD4(+) T cells isolated from similar patients. Our results suggest that combinations of different kinds of proviral activators may have important implications for reducing the size of latent HIV-1 reservoirs in HAART-treated patients. [less ▲]

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See detailp21(WAF1) gene promoter is epigenetically silenced by CTIP2 and SUV39H1.
Cherrier, Thomas ULg; Suzanne, S.; Redel, L. et al

in Oncogene (2009), 28(38), 3380-9

Mainly regulated at the transcriptional level, the cellular cyclin-dependent kinase inhibitor, CDKN1A/p21(WAF1) (p21), is a major cell cycle regulator of the response to DNA damage, senescence and tumor ... [more ▼]

Mainly regulated at the transcriptional level, the cellular cyclin-dependent kinase inhibitor, CDKN1A/p21(WAF1) (p21), is a major cell cycle regulator of the response to DNA damage, senescence and tumor suppression. Here, we report that COUP-TF-interacting protein 2 (CTIP2), recruited to the p21 gene promoter, silenced p21 gene transcription through interactions with histone deacetylases and methyltransferases. Importantly, treatment with the specific SUV39H1 inhibitor, chaetocin, repressed histone H3 lysine 9 trimethylation at the p21 gene promoter, stimulated p21 gene expression and induced cell cycle arrest. In addition, CTIP2 and SUV39H1 were recruited to the silenced p21 gene promoter to cooperatively inhibit p21 gene transcription. Induction of p21(WAF1) gene upon human immunodeficiency virus 1 (HIV-1) infection benefits viral expression in macrophages. Here, we report that CTIP2 further abolishes Vpr-mediated stimulation of p21, thereby indirectly contributing to HIV-1 latency. Altogether, our results suggest that CTIP2 is a constitutive p21 gene suppressor that cooperates with SUV39H1 and histone methylation to silence the p21 gene transcription. [less ▲]

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See detailIn memoriam Michel Dubuisson
Rochette, Bruno ULg

in Bulletin d’information de la Fédération des Professeurs de grec et de latin [= FPGL] (2009), 168

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See detailCarte hydrogéologique de Wallonie 1/25000 71/1-2 Meix-devant-Virton - Virton, notice explicative.
Bouezmarni, Mohamed ULg; Debbaut, Vincent ULg

Book published by SPW, DGARNE - peer reviewed (2009)

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See detailThe Surface Ocean CO2 Atlas (SOCAT) - Coastal Regional group
Borges, Alberto ULg; Chen, A. T. C.; The SOCAT Regional group

Poster (2009)

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See detailUnder which conditions did the Greeks “believe” in their myths? The religious criteria of adherence
Pirenne-Delforge, Vinciane ULg

in Walde, Christine; Dill, Ueli (Eds.) Antike Mythen. Medien, Transformationen, Konstruktionen. Festschriften für Fritz Graf (2009)

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See detailEffect of membrane permeability on survival of hemodialysis patients
Locatelli, Francesco; Martin-Malo, Alejandro; Hannedouche, Thierry et al

in Journal of the American Society of Nephrology [=JASN] (2009), 20

The effect of high-flux hemodialysis membranes on patient survival has not been unequivocally determined. In this prospective, randomized clinical trial, we enrolled 738 incident hemodialysis patients ... [more ▼]

The effect of high-flux hemodialysis membranes on patient survival has not been unequivocally determined. In this prospective, randomized clinical trial, we enrolled 738 incident hemodialysis patients, stratified them by serum albumin 4 and 4 g/dl, and assigned them to either low-flux or high-flux membranes. We followed patients for 3 to 7.5 yr. Kaplan-Meier survival analysis showed no significant difference between high-flux and low-flux membranes, and a Cox proportional hazards model concurred. Patients with serum albumin 4 g/dl had significantly higher survival rates in the high-flux group compared with the low-flux group (P 0.032). In addition, a secondary analysis revealed that high-flux membranes may significantly improve survival of patients with diabetes. Among those with serum albumin 4 g/dl, slightly different effects among patients with and without diabetes suggested a potential interaction between diabetes status and low serum albumin in the reduction of risk conferred by high-flux membranes. In summary, we did not detect a significant survival benefit with either high-flux or low-flux membranes in the population overall, but the use of high-flux membranes conferred a significant survival benefit among patients with serum albumin 4 g/dl. The apparent survival benefit among patients who have diabetes and are treated with high-flux membranes requires confirmation given the post hoc nature of our analysis. [less ▲]

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See detailGenetic Analysis of Rwandan Patients With Cystic Fibrosis-Like Symptoms: Identification of Novel Cystic Fibrosis Transmembrane Conductance Regulator and Epithelial Sodium Channel Gene Variants.
Mutesa, Léon; Azad, Abul Kalam; Verhaeghe, Catherine ULg et al

in CHEST (2009), 135(5), 1233-42

Background The defect in chloride and sodium transport in cystic fibrosis (CF) patients is a consequence of CFTR loss of function and of an abnormal interaction between CFTR and ENaC. A few patients were ... [more ▼]

Background The defect in chloride and sodium transport in cystic fibrosis (CF) patients is a consequence of CFTR loss of function and of an abnormal interaction between CFTR and ENaC. A few patients were described with CF-like symptoms, a single CFTR mutation and an ENaC mutation. Methods To study African patients with CF-like symptoms and to relate the disease to gene mutations of both CFTR and ENaC genes, we collected clinical data and DNA samples from 60 African patients with a CF phenotype. The CFTR gene was first analyzed in all patients by dHPLC followed by direct sequencing, whereas the SCNN1A, SCNN1B and SCNN1G subunits of ENaC gene were analyzed by sequencing in the five patients who carried only one CF mutation. The frequency of all identified ENaC variants was established in a control group of 200 healthy individuals and in the 55 CF-like patients without any CFTR mutation Results Three CFTR mutants, including one previously undescribed missense mutation (p.A204T), and a 5T/7T variant were identified in five patients. ENaC gene sequencing in these 5 patients detected 8 ENaC variants: c.72T>C and p.V573I in SCNN1A; p.V348M, p.G442V, c.1473 + 28C>T, and p.T577T in SCNN1B; and p.S212S, c.1176 + 30G>C in SCNN1G. In the 55 CF-like patients without any CFTR mutation, we identified five of these eight ENaC variants, including the frequent p.G442V polymorphism, but we did not detect the presence of the p.V348M, p.T577T, and c.1176 + 30G>C ENaC variants. Moreover, these last three ENaC variants, p.V348M, p.T577T, and c.1176 + 30G>C, were not found in the control group. Conclusion Our data suggest that CF-like syndrome in Africa could be associated with CFTR and ENaC mutations. [less ▲]

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See detailMulti-disciplinary investigation of the tomb of Menna (TT69), Theban Necropolis, Egypt
Vandenabeele, Peter; Garcia-Moreno, Renata; Mathis, François ULg et al

in Spectrochimica Acta Part A : Molecular and Biomolecular Spectroscopy (2009), 73(3), 546-552

The archaeometrical survey of the tomb of Menna (TT69), which took place in November-December 2007, is part of the extended research program that aims to study and preserve this tomb in all its aspects ... [more ▼]

The archaeometrical survey of the tomb of Menna (TT69), which took place in November-December 2007, is part of the extended research program that aims to study and preserve this tomb in all its aspects. Menna was a high official who served as an overseer of Cadastral surveys during the reigns of pharaohs Tuthmosis IV and Amenhotep Ill (ca. 1419-1370 BC). The research team aimed to gather information, in a totally non-destructive way, on the materials used and the painting techniques. The technical examinations included photography with normal and raking light. macrophotography, ultra-violet (UV) fluorescence photography, and microscopy. On selected points X-ray fluorescence (XRF) was combined with diffuse reflectance UV-spectrometry, near infrared (NIR) diffuse reflectance spectroscopy and Raman spectroscopy. The technical aspects as well as problems that are inherently associated with an interdisciplinary survey of this extent, are discussed. The project worked with a large team of people with different backgrounds and sensitive technical equipment. Working conditions were quite hostile, including elevated temperatures and dust hampering the examinations. (C) 2008 Elsevier B.V. All rights reserved. [less ▲]

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See detailUsing nursing interventions classification as a framework to revise the Belgian Nursing Minimum Data Set
VAN DEN HEEDE, Koen; MICHIELS, Dominik; THONON, Olivier ULg et al

in International Journal of Nursing Terminologies & Classifications (2009), 20(3), 122-31

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See detailTaphonomy and sedimentology of the ‘black marble’ of Denée, a fossil conservation deposit from the Viséan (Mississippian) of Belgium
Mottequin, Bernard ULg

in Godefroit, Pascal; Lambert, OLivier (Eds.) Tribute to Charles Darwin and Bernissart Iguanodons: New perspectives on vertebrate evolution and Early Cretaceous ecosystems. Programme, abstracts and field trips guidebook (2009)

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See detailGenetic variability of milk fatty acids.
Arnould, Valérie ULg; Soyeurt, Hélène ULg

in Journal of Applied Genetics (2009), 50(1), 29-39

The milk fatty acid (FA) profile is far from the optimal fat composition in regards to human health. The natural sources of variation, such as feeding or genetics, could be used to increase the ... [more ▼]

The milk fatty acid (FA) profile is far from the optimal fat composition in regards to human health. The natural sources of variation, such as feeding or genetics, could be used to increase the concentrations of unsaturated fatty acids. The impact of feeding is well described. However, genetic effects on the milk FA composition begin to be extensively studied. This paper summarizes the available information about the genetic variability of FAs. The greatest breed differences in FA composition are observed between Holstein and Jersey milk. Milk fat of the latter breed contains higher concentrations of saturated FAs, especially short-chain FAs. The variation of the delta-9 desaturase activity estimated from specific FA ratios could explain partly these breed differences. The choice of a specific breed seems to be a possibility to improve the nutritional quality of milk fat. Generally, the proportions of FAs in milk are more heritable than the proportions of these same FAs in fat. Heritability estimates range from 0.00 to 0.54. The presence of some single nucleotide polymorphisms could explain partly the observed individual genetic variability. The polymorphisms detected on SCD1 and DGAT1 genes influence the milk FA composition. The SCD1 V allele increases the unsaturation of C16 and C18. The DGAT1 A allele is related to the unsaturation of C18. So, a combination of the molecular and quantitative approaches should be used to develop tools helping farmers in the selection of their animals to improve the nutritional quality of the produced milk fat. [less ▲]

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See detailTerritorial reconversion and territorial knowledge: added-value of a territorial intelligence process in Flémalle (Belgium)
Breuer, Christophe ULg; Devillet, Guénaël ULg; Merenne-Schoumaker, Bernadette ULg

Conference (2009)

Our communication aims at spreading the participative approach implemented in Flémalle (“new governorship”), but also at discussing the contribution of the theorical and applied research undertaken within ... [more ▼]

Our communication aims at spreading the participative approach implemented in Flémalle (“new governorship”), but also at discussing the contribution of the theorical and applied research undertaken within the framework of the coordination action of the European Network of Territorial Intelligence for local projects (NTIC, participation, animation, analyzes….), the objective is to measure its added-value and transposability within territories of industrial tradition in a context of financial and temporal limitations. [less ▲]

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See detailEx vivo expansion of hematopoietic progenitor cells is associated with downregulation of alpha4 integrin- and CXCR4-mediated engraftment in NOD/SCID beta2-microglobulin-null mice
Foguenne, Jacques ULg; Di Stefano; Giet, Olivier ULg et al

in Haematologica (2009), 94

Several studies indicate that ex vivo cytokine-supported expansion induces defective hematopoietic stem cell engraftment. We investigated the role of alpha4 integrin, alpha5 integrin and CXCR4 in ... [more ▼]

Several studies indicate that ex vivo cytokine-supported expansion induces defective hematopoietic stem cell engraftment. We investigated the role of alpha4 integrin, alpha5 integrin and CXCR4 in engraftment of unmanipulated and cytokine-treated human cord blood CD34+ cells. [less ▲]

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See detailCarbon cycling in the mixolimnion of Lake Kivu (East Africa)
Borges, Alberto ULg; Descy, J.-P.; Delille, Bruno ULg et al

Poster (2009)

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