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See detailHematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT.
Sorror, Mohamed L; Maris, Michael B; Storb, Rainer et al

in Blood (2005), 106(8), 2912-9

We previously reported that the Charlson Comorbidity Index (CCI) was useful for predicting outcomes in patients undergoing allogeneic hematopoietic cell transplantation (HCT). However, the sample size of ... [more ▼]

We previously reported that the Charlson Comorbidity Index (CCI) was useful for predicting outcomes in patients undergoing allogeneic hematopoietic cell transplantation (HCT). However, the sample size of patients with scores of 1 or more, captured by the CCI, did not exceed 35%. Further, some comorbidities were rarely found among patients who underwent HCT. Therefore, the current study was designed to (1) better define previously identified comorbidities using pretransplant laboratory data, (2) investigate additional HCT-related comorbidities, and (3) establish comorbidity scores that were suited for HCT. Data were collected from 1055 patients, and then randomly divided into training and validation sets. Weights were assigned to individual comorbidities according to their prognostic significance in Cox proportional hazard models. The new index was then validated. The new index proved to be more sensitive than the CCI since it captured 62% of patients with scores more than 0 compared with 12%, respectively. Further, the new index showed better survival prediction than the CCI (likelihood ratio of 23.7 versus 7.1 and c statistics of 0.661 versus 0.561, respectively, P < .001). In conclusion, the new simple index provided valid and reliable scoring of pretransplant comorbidities that predicted nonrelapse mortality and survival. This index will be useful for clinical trials and patient counseling before HCT. [less ▲]

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See detailAnalysis of Pollen and Nectar of Arbutus unedo as a Food Source for Bombus terrestris (Hymenoptera : Apidae)
Rasmont, Pierre; Regali, Ariane; Ings, Thomas C. et al

in Journal of Economic Entomology (2005), 98(3), 656-663

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See detailDevelopment Of An Enzymatic Assay For The Determination Of Cellulose Bioavailability In Municipal Solid Waste
Rodriguez, Christian; Hiligsmann, Serge ULg; Ongena, Marc ULg et al

in Biodegradation (2005), 16(5), 415-422

As there is a constant need to assess the biodegradation potential of refuse disposed of in landfills, we have developed a method to evaluate the biodegradability of cellulosic compounds (cellulose and ... [more ▼]

As there is a constant need to assess the biodegradation potential of refuse disposed of in landfills, we have developed a method to evaluate the biodegradability of cellulosic compounds (cellulose and hemicellulose) in municipal solid waste. This test is based on the quantification of monosaccharids released after the hydrolysis of solid waste samples with an optimised enzyme preparation containing commercially available cellulases and hemicellulases. We show that the amounts of monosaccharids could be related to the biodegradability of the cellulosic material contained in the samples. This enzymatic cellulose degradation test was assayed on 26 samples originating from two Belgian landfills and collected at different depths. As results correlated well with those obtained with a classical biochemical methane potential assay, this new and rapid test is sufficiently reliable to evaluate cellulose bioavailability in waste samples. [less ▲]

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See detailEffect of tank mixed adjuvants on the drift potential of phenmedipham formulations.
Stainier, Charles; Destain, Marie-France ULg; Schiffers, Bruno ULg et al

in Communications in agricultural and applied biological sciences (2005), 70(4), 979-987

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See detailHeating Effects On Some Quality Characteristics Of Date Seed Oil
Besbes, Souhail; Blecker, Christophe ULg; Deroanne, Claude et al

in Food Chemistry (2005), 91(3), 469-476

Effects of heating on some quality characteristics of date seed oil from two cultivars (Deglet Nour and Allig) has been investigated using an accelerated test in a Rancimat system. Fatty acid, viscosity ... [more ▼]

Effects of heating on some quality characteristics of date seed oil from two cultivars (Deglet Nour and Allig) has been investigated using an accelerated test in a Rancimat system. Fatty acid, viscosity, absorptivity at 232 and 270 nm, colour and total melting enthalpy of Deglet Nour seed oil were less changed compared to that of Allig seed oil, because the former contained a higher amount of total phenolic compounds (526 lg/g against 215 lg/g) and a lower content of unsaturated fatty acids. Viscosity and absorptivity at 232 nm and at 270 nm increased rapidly after reaching the oxidation induction time. Differential scanning calorimetry melting profiles of date seed oils were also changed after heating in the Rancimat. Melting enthalpies seemed to be constant during the initial stages of Rancimat treatment and then reduced after the induction time was reached. The obtained data shows that date seed oils were resistant to thermal treatment during a long period ( 30–40 h). This may indicate that they could bear thermal treatments that could be applied in refining procedures or in culinary treatments such as frying and cooking conditions. We could also expect that they may have a good shelf life. [less ▲]

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See detailMapk Pathway Contributes To Density- And Hypoxia-Induced Expression Of The Tumor-Associated Carbonic Anhydrase Ix
Kopacek, J.; Barathova, M.; Dequiedt, Franck ULg et al

in Biochimica et Biophysica Acta-Gene Structure and Expression (2005), 1729(1),

Transcription of the CA9 gene coding for a tumor-associated carbonic anhydrase IX (CA IX) isoform is regulated by hypoxia via the hypoxia-inducible factor 1 (HIF-1) and by high cell density via the ... [more ▼]

Transcription of the CA9 gene coding for a tumor-associated carbonic anhydrase IX (CA IX) isoform is regulated by hypoxia via the hypoxia-inducible factor 1 (HIF-1) and by high cell density via the phosphatidylinositol-3-kinase (PI3K) pathway. We examined the role of the mitogen-activated protein kinase (MAPK) pathway in the control of CA9 gene expression. Inhibition of MAPK signaling by U0126 in HeLa cells led to reduced activity of the PR1-HRE-luc CA9 promoter construct and decreased CA IX protein levels in dense culture as well as in hypoxia. Similar reduction was obtained by expression of a dominant-negative ERK1 mutant and was also observed in U0126-treated HIF-1alpha-deficient Ka13 cells. Simultaneous treatment with the MAPK and PI3K inhibitors U0126 and LY 294002 had stronger effect than individual inhibition of these pathways. Taken together, our results suggest that besides the PI3K pathway, the MAPK cascade is involved in the regulation of CA9 gene expression under both hypoxia and high cell density. [less ▲]

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See detailNew Model For Performance Prediction In Fixed-Bed Reactors Based On The Approach Of The Unused Bed Zone
Fanfan, Pierre Naïder; Mabon, Nicolas; Carletti, Isabelle et al

in Water Research (2005), 39(16), 4004-4010

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See detailPolyphasic Identification Of A New Thermotolerant Species Of Lactic Acid Bacteria Isolated From Chicken Faeces
Sow, Nm.; Dubois Dauphin, Robin ULg; Weber, Dominique ULg et al

in African Journal of Biotechnology (2005), 4(5),

Two thermotolerant and desiccation tolerant lactic acid bacteria (TDLAB) were pointed out from twenty isolated strains from soils and dried chicken faeces. Samples were collected in poultry farms in the ... [more ▼]

Two thermotolerant and desiccation tolerant lactic acid bacteria (TDLAB) were pointed out from twenty isolated strains from soils and dried chicken faeces. Samples were collected in poultry farms in the vicinity of Dakar, Senegal (West Africa). The two new isolates were called Sp.4 (Sp.4=CWBI-B534=LMG7278) and Sp.20 (Sp.20=CWBI-B545=LMG7279). They are Grampositive, catalase-negative, facultatively anaerobic, non-motile, and non-spore-forming rods. Both produce D/L lactic acid via homofermentative pathway. Growth of the strains occurred between 15°C and 44°C. The optimum temperature for growth was in 30°C-37°C temperature and pH 3-8 range. Desiccation treatment in glycerol showed 30% survival rates. Complex total fatty acid pattern of the strains showed the presence of C14:0, C16:0, C16:1, C18:0, C18:1, C18:2, C18:3. SDS-PAGE of total protein of both strains placed them in L. plantarum group. AFLP analysis showed a phylogenetic proximity of the two strains with L. plantarum stricto sensu species. Specific amplified 16s rDNA restriction analysis (ARDRA) of the 16S rDNA gene, however, showed that these thermotolerant strains were not L. plantarum. ITS sequencing revealed that Sp.20 (LMG 7279) could be classed into Lactobacillus paraplantarum species since the short sequence of ITS showed 95% of similarity with reference species. Polyphasic identification shows that Sp.4, (the type strain is LMG 7278T) represent a new species within the genus Lactobacillus with only 88%+/-1 ITS sequence similarity with reference species. For which the name Lactobacillus aminata sp. nov. is proposed. [less ▲]

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See detailVolatile Constituents And Antimicrobial Activity Of Lavandula Stoechas L. Oil From Tunisia
Bouzouita, N.; Kachouri, F.; Hamdi, M. et al

in Journal of Essential Oil Research (2005), 17(5), 584-586

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See detailCurrent roles for allogeneic hematopoietic cell transplantation following nonmyeloablative or reduced-intensity conditioning.
Baron, Frédéric ULg; Storb, Rainer

in Clinical Advances in Hematology & Oncology (2005), 3(10), 799-819

Nonmyeloablative and reduced-intensity conditioning regimens followed by allogeneic hematopoietic cell transplantation (HCT) have been evaluated in patients with hematologic malignancies who were not ... [more ▼]

Nonmyeloablative and reduced-intensity conditioning regimens followed by allogeneic hematopoietic cell transplantation (HCT) have been evaluated in patients with hematologic malignancies who were not considered candidates for conventional HCT because of age or medical comorbidities and in selected patients with metastatic renal cell carcinoma. The regimens have relied more on graft-versus-tumor effects than on chemoradiation therapy to facilitate engraftment and eradicate malignant cells. While nonmyeloablative HCT has been associated with reduced regimen-related toxicities and has been curative for a number of patients with hematologic malignancies, challenges have remained in regard to graft-versus-host disease, infections, and disease progression. In this article, we review data from a number of published phase I and II studies that describe the results of allogeneic HCT after nonmyeloablative conditioning. [less ▲]

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See detailSocial Science Research and Public Policies: the Case of Immigration in Belgium
Martiniello, Marco ULg; Florence, Eric ULg

in International Journal on Multicultural Societies (2005), 7(1), 49-67

This paper summarises the major insights of a two-year interuniversity research project carried out between 2001 and 2003. The methodological framework gives a central meaning to the domestic and ... [more ▼]

This paper summarises the major insights of a two-year interuniversity research project carried out between 2001 and 2003. The methodological framework gives a central meaning to the domestic and international political context. After building and analysing a database gathering all Belgian academic research relating to migration and ethnic relations from 1989 to 2002, the two most widely researched domains of education and the labour market were thoroughly investigated in order to assess how social research has affected policy-making and agenda-setting in the field of migration and ethnic relations in Belgium. The weight of history and ideology, the importance of disseminating research results, and the role of institutional structures between research and policy-making, are all highlighted as core determinants of the influence of research. The paper also points to the relevance of an analysis aimed at taking into account the role of different factors – political paradigm, political context, specificity of field, etc. – in the process of knowledge utilisation at the political level. Finally, a series of recommendations are made on improving the links between social science research and policy-making in the field of migration and ethnic relations. [less ▲]

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See detailPlusieurs épidémies de fièvre hémorragique due au virus Ebola au Gabon, d'octobre 2001 à avril 2002
Nkoghe Mba, Dieudonne ULg; Formenty, P; Leroy, E M et al

in Bulletin de la Société de Pathologie Exotique (2005), 98(3), 224-229

Des épidémies de fièvre hémorragique virale à virus Ebola (FHVE) ont été rapportées de 1994 à 1996 dans la province de l’Ogooué Ivindo, une zone forestière située au Nord Est du Gabon. Chaque fois, les ... [more ▼]

Des épidémies de fièvre hémorragique virale à virus Ebola (FHVE) ont été rapportées de 1994 à 1996 dans la province de l’Ogooué Ivindo, une zone forestière située au Nord Est du Gabon. Chaque fois, les grands primates avaient été reconnus comme la source initiale de l’infection humaine. Fin novembre 2001 une nouvelle alerte est venue de cette province qui a rapidement était confirmée comme étant une épidémie de FHVE. La riposte a été organisée par le ministère de la santé publique avec l’aide d’une équipe internationale sous l’égide de l’OMS. Un système de surveillance active a été mis en place dans les trois districts touchés par l’épidémie (Zadié, Ivindo and Mpassa) afin d’organiser la détection des cas et le suivi de leur contacts. Une définition de cas a été adoptée, les cas suspects étaient isolés à l’hôpital, à domicile ou dans des lazarets, et des tests sérologiques étaient réalisés. Ces tests comportaient la détection de l’antigène ou des IgG spécifiques, et la RT-PCR. Un classement des cas était réalisé en fonction des résultats des tests biologiques et des données cliniques et épidémiologiques. Les sujets contacts étaient surveillés durant 21 jours. On a dénombré 65 cas dont 53 décès. Le premier cas humain, un chasseur, était décédé le 28 octobre 2001. L’épidémie s’est propagée grâce une transmission familiale et une contamination nosocomiale. Quatre foyers primaires distincts ont été mis en évidence ainsi qu’un cas isolé situé dans le Sud est du Gabon, à 580 km de l’épicentre, Les décès sont survenus dans un délai de 6 jours. Le dernier décès a été enregistré le 22 mars 2002 et la fin de l’épidémie déclarée le 6 mai 2002. L’épidémie s’est étendue au Congo voisin. Des morts inexpliquées d’animaux avaient été signalées dans les forêts environnantes dès le mois d’août 2001 : des grands primates et des céphalophes. Les prélèvements réalisés sur leurs carcasses confirmaient une épidémie animale concomitante. [less ▲]

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See detailVortex-antivortex dynamics and field-polarity-dependent flux creep in hybrid superconductor/ferromagnet nanostructures
Lange, M.; Van Bael, M. J.; Silhanek, Alejandro ULg et al

in Physical Review. B : Condensed Matter (2005), 72(5),

Vortex-antivortex arrays (VAA) that are created in a type-II superconducting film by lattices of ferromagnetic dots with perpendicular anisotropy have been investigated. The highest critical current is ... [more ▼]

Vortex-antivortex arrays (VAA) that are created in a type-II superconducting film by lattices of ferromagnetic dots with perpendicular anisotropy have been investigated. The highest critical current is shifted to a nonzero value of the applied field, and current-voltage characteristics show different regimes of vortex motion even in zero-applied field due to the presence of the VAA. Creep of interstitial vortices is observed at low driving forces. This flux creep is strongly field-polarity dependent. [less ▲]

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See detailBringing animal welfare into public debate
Lamine, Claire; Stassart, Pierre M ULg

in Environment, knowledge and democracy” University of the Mediteranean (2005)

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See detailRestrictieve focuspartikels in het Nederlands: enkel en uitsluitend en alleen (maar) problemen voor Franstaligen?
Meesters, Gert ULg

in Hiligsmann, Philippe; Beheydt, Ludo; Degand, Liesbeth (Eds.) et al Neerlandistiek in Frankrijk en in Franstalig België / Les études néerlandaises en France et en Belgique francophone (2005)

Dans cet article, il est question des différentes particules qui permettent au néerlandophone de mettre une partie de la phrase en évidence et d'exprimer en même temps une limitation. Il s'agit des ... [more ▼]

Dans cet article, il est question des différentes particules qui permettent au néerlandophone de mettre une partie de la phrase en évidence et d'exprimer en même temps une limitation. Il s'agit des particules synonymes alleen, maar, alleen maar, slechts, enkel, louter, uitsluitend. Après une brève introduction au monde des particules et l'analyse de quelques phrases rédigées par des francophones qui apprennent le néerlandais, il sera démontré qu'il n'est pas évident, même pour des néerlandophones, de savoir si une particule est utilisée correctement ou non. Des recherches dans des corpus de textes pourront aider à trouver une solution à ce problème. Au moyen de recherches dans un corpus de textes bien structuré, il sera possible de découvrir des caractéristiques sémantiques, syntaxiques ainsi que des caractéristiques de variation stylistique et régionale qui distinguent ces particules quasi synonymes. Les résultats de ces recherches seront utiles à la didactique du néerlandais langue étrangère en ce qui concerne les particules. [less ▲]

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See detailReconstruction of incomplete oceanographic data sets using empirical orthogonal functions: application to the Adriatic Sea surface temperature
Alvera Azcarate, Aïda ULg; Barth, Alexander ULg; Rixen, Michel et al

in Ocean Modelling (2005), 9(4), 325-346

A method for the reconstruction of missing data based on an EOF decomposition has been applied to a large data set, a test case of Sea Surface Temperature satellite images of the Adriatic Sea. The EOF ... [more ▼]

A method for the reconstruction of missing data based on an EOF decomposition has been applied to a large data set, a test case of Sea Surface Temperature satellite images of the Adriatic Sea. The EOF decomposition is realised with a Lanczos method, which allows optimising computational time for large matrices. The results show that the reconstruction method leads to accurate reconstructions as well as a low cpu time when dealing with realistic cases. The method has been tested with different amounts of missing data, artificially adding clouds ranging from 40% to 80% of data loss, and then compared to the same data set with no missing data. A comparison with in situ data has also been made. These validation studies show that results are robust, even when the amount of missing data is very high. The reconstruction of the data from the Adriatic Sea shows realistic features and a reliable temperature distribution. In addition, the method is compared to an Optimal Interpolation reconstruction. The results obtained with both methods are very similar. The main difference is the computational time, which is reduced nearly 30 times with the method presented here. Once the reconstruction has been performed, the EOF decomposition is analysed to show the method's reliability, and a cold event on the Albanian coast is studied. The reconstructed data reflect the effect of wind on the Albanian coast, that led to a cold-water episode in this zone for a 6-day period. (c) 2004 Elsevier Ltd. All rights reserved. [less ▲]

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See detailStructure of light and heavy pentaquarks
Stancu, Floarea ULg

in International Journal of Modern Physics A : Particles & Fields, Gravitation, Cosmology, Nuclear Physics (2005), 20(8-9), 1797-1802

Light and heavy pentaquarks are described within a constituent quark model based on a spin-flavor hyperfine interaction. In this model the lowest state acquires positive parity. The masses of the light ... [more ▼]

Light and heavy pentaquarks are described within a constituent quark model based on a spin-flavor hyperfine interaction. In this model the lowest state acquires positive parity. The masses of the light antidecuplet members are calculated dynamically using a variational method. It is shown that the octet and antidecuplet states with the same quantum numbers mix ideally due to SU (3)(F) breaking. Masses of the charmed antisextet pentaquarks are predicted within the same model. [less ▲]

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See detailThe discovery and properties of pentaquarks
Stancu, Floarea ULg

in International Journal of Modern Physics A : Particles & Fields, Gravitation, Cosmology, Nuclear Physics (2005), 20(2-3), 209-218

The pentaquarks are exotic baryons formed of four quarks and an antiquarks. Their existence has been discussed in the literature over the last 30 years or more, first in connection with kaon nucleon ... [more ▼]

The pentaquarks are exotic baryons formed of four quarks and an antiquarks. Their existence has been discussed in the literature over the last 30 years or more, first in connection with kaon nucleon scattering data. The subject has been revived by the end of 2002 when experimental evidence of a narrow baryon of strangeness S = +1, and mass M similar or equal to 1530 MeV has been found. This is interpreted as the lightest member of an SU(3)-flavor antidecuplet. Here we shall mainly review the predictions of pentaquark properties as e.g. mass, spin and parity, within constituent quark models. Both light and heavy pentaquarks will be presented. [less ▲]

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See detailRecent Evolution of atmospheric OCS above the Jungfraujoch station : implications for the stratospheric aerosol layer.
Mahieu, Emmanuel ULg; Zander, Rodolphe ULg; Demoulin, Philippe ULg et al

in Proceedings of the Atmospheric Spectroscopy Applications. (2005)

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