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See detailCréation d'entreprise et utilisation de l'informatique
Robert, Jocelyne ULg

in Quel genre pour l'égalité? (2003)

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See detailEffects of Alzheimer's disease on the recognition of novel versus familiar words : Neuropsychological and clinico-metabolic data
Lekeu, Françoise ULg; Van der Linden, Martial ULg; Degueldre, Christian ULg et al

in Neuropsychology (2003), 17(1), 143-154

This study explored recognition memory performance for novel versus familiar words in Alzheimer's disease (AD) patients and normal controls (NCs), using an adaptation of E. Tulving and N. Kroll's (1995 ... [more ▼]

This study explored recognition memory performance for novel versus familiar words in Alzheimer's disease (AD) patients and normal controls (NCs), using an adaptation of E. Tulving and N. Kroll's (1995) procedure. Results showed that both groups exhibited more hits and more false alarms for familiar than for novel words. The groups did not differ in the recognition of familiar words, reflecting preserved familiarity processes in AD. However, AD patients made more false alarms than NCs in the recognition of novel words, reflecting impairment of recollection processes in AD. A positron emission tomography analysis of clinico-metabolic correlations in AD patients showed a correlation between recognition of novel words and right hippocampal activity, whereas recognition of familiar words was more related to metabolic activity in the left posterior orbitofrontal cortex. [less ▲]

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See detailPharmacological evaluation of the novel thromboxane modulator BM-567 (I/II). Effects of BM-567 on platelet function
Dogne, J. M.; de Leval, X.; Kolh, Philippe ULg et al

in Prostaglandins, Leukotrienes, and Essential Fatty Acids (2003), 68(1), 49-54

The aim of this work was to evaluate the effects of BM-567 ( N-pentyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea), a torasemide derivative. on both thromboxane A(2) (TXA(2)) receptors (TP) and ... [more ▼]

The aim of this work was to evaluate the effects of BM-567 ( N-pentyl-N'-[(2-cyclohexylamino-5-nitrobenzene)sulfonyl]urea), a torasemide derivative. on both thromboxane A(2) (TXA(2)) receptors (TP) and thromboxane synthase of human platelets. The drug affinity for TP receptors of human washed platelets has been determined. In this test BM-567 showed a high affinity (IC50: 1.1+/-0.1 nM) for the TP receptors in comparison with BM-531 (IC50: 7.8+/-0.7 nM) and sulotroban (IC50: 931+/-85 nM), two TXA(2) antagonists. We also demonstrated that BM-567 prevented platelet aggregation induced by arachidonic acid (AA) (600 muM) (ED100: 0.20+/-0.10muM), U-46619, a stable TXA(2) agonist (1 muM) (ED50: 0.30+/-0.04 muM) and collagen (1 mug ml(-1)) (% of inhibition: 44.3+/-4.3% at 10 muM) and inhibited the second wave of ADP (2 muM). Moreover, when BM-567 was incubated in whole blood from healthy donors, the closure time measured by the Platelet Function analyzer (PFA-100) was significantly prolonged (closure time: 215+/-21 s) by using collagen/epinephrine cartridges. Finally, at the concentration of 1 muM, BM-567 completely reduced the TXB2 production from human platelets stimulated with AA (600 muM). These results indicate that BM-567 is a novel combined TXA(2) receptor antagonist and thromboxane synthase inhibitor characterized by a powerful antiplatelet potency. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailLes anevrysmes ventriculaires: principes de leur traitement chirurgical
Radermecker, M.A.; Moscato, A.; Coimbra, C. et al

in Revue Médicale de Liège (2003), 58(1), 33-6

After reviewing the historical background, the morphology and physiopathology of left ventricular aneurysms, the authors review the physiology, the technical aspects, and the current surgical indications ... [more ▼]

After reviewing the historical background, the morphology and physiopathology of left ventricular aneurysms, the authors review the physiology, the technical aspects, and the current surgical indications of aneurysmectomy, with a particular emphasis on the concept of endoventriculoplasty of Jatene [less ▲]

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See detailAppliquer le nez électronique pour reconnaître et suivre en continu de mauvaises odeurs dans l'environnement
Nicolas, Jacques ULg

Conference (2003, January)

Le nez électronique avec une configuration très simple fournit des résultats encourageants pour détecter une odeur dans l’environnement. Il existe un réel espoir de pouvoir fabriquer des instruments ... [more ▼]

Le nez électronique avec une configuration très simple fournit des résultats encourageants pour détecter une odeur dans l’environnement. Il existe un réel espoir de pouvoir fabriquer des instruments portables capables de prévoir une odeur inconnue en temps réel sur le terrain. Le monitoring des odeurs environnementales est un challenge, mais une simple estimation est suffisante, il n'y a pas besoin de conditions opératoires très rigoureuses. Il reste néanmoins beaucoup de travail à faire avant que le nez électronique ne devienne une réalité dans l’environnement. La communication présente ce challenge en l'illustrant par de nombreuses applications réalisées par l'équipe de recherche. [less ▲]

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See detailFire tests and calculation methods for circular concrete columns
Franssen, Jean-Marc ULg; Dotreppe, Jean-Claude ULg

in Fire Technology (2003), 39(1), 89-97

The introduction sets the scene of the present paper i.e. the extensive research works performed at the University of Liege in order to derive acceptable calculation methods for the re design of concrete ... [more ▼]

The introduction sets the scene of the present paper i.e. the extensive research works performed at the University of Liege in order to derive acceptable calculation methods for the re design of concrete columns. It is explained that all previous works have been based on square or rectangular cross sections, for which corner spalling was observed very often, whereas circular section are nowadays becoming more and more popular. In order to examine the influence of the circular shape on the behavior under re conditions, an experimental research study has been performed recently at the University of Liege. This paper describes the test procedure, the observations made, and the values obtained for the re resistance. Theoretical methods have been developed for a quick, safe, and efficient design of concrete columns under re conditions. These methods have been applied successfully to the recently tested circular columns. [less ▲]

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See detailLes facteurs de succès dans l'accompagnement du portage à distance de cours
Delfosse, Catherine ULg; Harmeling, Danielle; Poumay, Marianne ULg et al

in Actes du Colloque des deuxièmes rencontres du Kirchberg. (2003, January)

This paper presents a reflection about the key success factors involved in the process of turning traditional courses into on-line active courses. Within the context of ‘FORMADIS’ and other programmes ... [more ▼]

This paper presents a reflection about the key success factors involved in the process of turning traditional courses into on-line active courses. Within the context of ‘FORMADIS’ and other programmes, more than twenty projects have been accompanied by the LabSET in the past 3 years. The paper gives an overview of the tools and methods used for teacher support and training. It examines the projects ‘doing well’ and analyse what makes them sucessful. It considers the moment at which the success factors take place (before, during and after the various phases of development). It illustrates these key factors with practical examples. Whereas the majority of these factors seem to be obvious, this analysis will help considering the relations between them as well as the way of managing them successfully. [less ▲]

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See detailMutuelle communautaire de croissance (MC²) et développement rural à Baham (Cameroun)
Lekane Tsobgou, Dieudonné ULg

in Cahiers d'Outre-Mer (Les) (2003), 221(janvier-Maars), 67-86

A micro-bank for rural development in Baham (Cameroon). The creation of microfinancing institutions for rural activities has enabled rural development to take off in poor countries. In Baham, amicro-bank ... [more ▼]

A micro-bank for rural development in Baham (Cameroon). The creation of microfinancing institutions for rural activities has enabled rural development to take off in poor countries. In Baham, amicro-bank was created with the technical and financial support of such partners as the ADAF and the afriland first-Bank. It aims at combining modern techniques of management and sociocultural values, in order to make as many members as possible benefit by its services. This study focuses on the nature and the functioning of the bank, its means of action and financing, its role in the agro-pastoral development and the socio-economical evolution of the district and of the village. [less ▲]

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See detailLa prévention de la violence dans le sport
Comeron, Manuel ULg

Book published by Conseil de l'Europe (2003)

En ce début de siècle, nous assistons à un changement du type de violence associé aux manifestations sportives, notamment aux matches de football. En effet, la violence dans le sport, qui se cantonnait ... [more ▼]

En ce début de siècle, nous assistons à un changement du type de violence associé aux manifestations sportives, notamment aux matches de football. En effet, la violence dans le sport, qui se cantonnait aux stades de football et avait un caractère exceptionnel et spontané, a gagné les zones urbaines et le coeur des villes. La société contemporaine est désormais confrontée à une violence dans le sport souvent préméditée et généralement provoquée par un noyau dur de supporters qui recherchent la confrontation systématique et organisée, lors des matches et des tournois locaux, nationaux et internationaux. Etant donné que le hooliganisme devient international et crée des problèmes similaires en Europe et partout dans le monde, il est nécessaire de lui apporter, à l’échelle internationale, une réponse commune et concertée, axée sur la prévention. La prévention de la violence dans le sport propose des actions et des structures fondées sur des expériences en cours qui ont montré une certaine efficacité. Ces initiatives donnent une gamme de solutions permettant de mettre en place des activités de prévention intégrées de haut niveau, qui peuvent être adaptées aux besoins locaux. [less ▲]

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See detailThe prevention of violence in sport
Comeron, Manuel ULg

Book published by Coucil of Europe Publishing (2003)

The beginning of this century has seen a shift in the type of violence associated with sports events, in particular football. Once contained by football grounds and generally one-off and spontaneous in ... [more ▼]

The beginning of this century has seen a shift in the type of violence associated with sports events, in particular football. Once contained by football grounds and generally one-off and spontaneous in nature, sports violence has moved to urban areas and city centres. Contemporary society is now confronted with sports violence which is often premeditated, and commonly involves hard-core supporters who seek systematic and organised confrontation at local, national and international matches and tournaments. As hooliganism becomes international, generating similar problems in Europe and throughout the world, a common and concerted preventive response at international level is needed. The prevention of violence in sport proposes actions and structures based on experiments in progress which have already shown some degree of effectiveness. These initiatives open up a range of solutions for developing integrated preventive activities of a high standard that can be adapted to local needs. [less ▲]

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See detailCompte-rendu de l'ouvrage Interviste a d'Annunzio (1895-1938)
Curreri, Luciano ULg

in ARIEL. Quadrimestrale di drammaturgia dell'Istituto di Studi pirandelliani e sul Teatro Italiano Contempornaeo (2003), 1

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See detailEffect of manipulation and irrelevant noise on working memory capacity of patients with Alzheimer's dementia
Belleville, Sylvie; Rouleau, Nancy; Van der Linden, Martial ULg et al

in Neuropsychology (2003), 17(1), 69-81

The effect of manipulation and distracting noise on immediate serial recall was measured in patients with dementia of the Alzheimer type (DAT), neurologically healthy elderly individuals and young adults ... [more ▼]

The effect of manipulation and distracting noise on immediate serial recall was measured in patients with dementia of the Alzheimer type (DAT), neurologically healthy elderly individuals and young adults. In experiment 1, the authors compared serial word recall with word recall in alphabetical order. Alphabetical recall requires the active manipulation of the contents of working memory. Findings indicated that DAT patients were severely impaired in the alphabetical recall task, whereas the performance of neurologically healthy elderly participants was comparable with the performance of young adult participants. In experiment 2, the authors investigated the effect of different irrelevant auditory backgrounds on immediate digit recall. In this task, both elderly participants and DAT patients performed similarly to the group of young adult participants, indicating comparable efficacy to resist auditory distraction. [less ▲]

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See detailEuropean Organization for Research and Treatment of Cancer (EORTC) 08957 phase II study of topotecan in combination with cisplatin as second-line treatment of refractory and sensitive small cell lung cancer
Ardizzoni, A.; Manegold, C.; Debruyne, C. et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (2003), 9(1), 143-150

Purpose: The purpose of this study was to assess the activity and toxicity of a combined regimen of topotecan and cisplatin in "sensitive" (s) and "refractory" (r) small-cell lung cancer (SCLC) patients ... [more ▼]

Purpose: The purpose of this study was to assess the activity and toxicity of a combined regimen of topotecan and cisplatin in "sensitive" (s) and "refractory" (r) small-cell lung cancer (SCLC) patients treated previously. Experimental Design: Patients with measurable SCLC and progressive disease after one first-line regimen were eligible for the study. Patients were enrolled in two separate groups: r group (patients who failed first-line treatment <3 months from treatment discontinuation) and s group (patients who responded to first-line treatment and progressed 2:3 months after treatment discontinuation). Cisplatin was given i.v. at the dose of 60 mg/m(2) on day 1, and topotecan was administered as a daily i.v. infusion at the dose of 0.75 mg/m(2) from day 1 to 5, every 3 weeks. Results: A total of 110 eligible (68 s and 42 r) patients were enrolled from 24 institutions. The main patient characteristics were as follows: median age 60 (s) and 55 (r) years, median performance status 1 for both (s) and (r). Seventy-four percent (s) and 67% (r) had extensive stage disease, including 22% and 36%, respectively, with brain metastases. A total of 398 chemotherapy courses were administered [median 4 (s) and 3 (r) per patient]. The most frequent and serious toxicity was myelosuppression. Grade IV neutropenia occurred in 62% (s) and 49% (r) of patients, with a 19% (s) and 15% (r) incidence of febrile neutropenia, and grade IV thrombocytopenia in 54% (s) and 44% (r). Most of these toxicities occurred during the first chemotherapy course and led to topotecan dose reduction and/or delay in the following courses. Grade III-IV nonhematological toxicity was uncommon. Five deaths possibly related to toxicity occurred among s patients only. Objective responses have been documented in 20 s patients, 19 partial responses and 1 complete response, (29.4% response rate; 95% confidence interval, 19-42), whereas, among r patients, 10 partial responses have been observed (23.8% response rate; 95% confidence interval, 12-39). Median survival for s and r was 6.4 and 6.1 months, respectively. Conclusions: The combination of cisplatin and topotecan, at this dose and schedule, shows activity and promising results in patients with refractory SCLC, with reversible myelosuppression being the main side effect. Additional development of this regimen, using better-tolerated schedules, is warranted in patients with refractory SCLC. [less ▲]

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See detailThe stem cell mobilizing capacity of patients with acute myeloid leukemia in complete remission correlates with relapse risk: results of the EORTC-GIMEMA AML-10 trial
Keating, S.; Suciu, S.; de Witte, T. et al

in Leukemia (2003), 17(1), 60-67

Variable numbers of CD34(+) cells can be harvested from the blood of AML patients in CR after G-CSF supported mobilization following consolidation chemotherapy. We hypothesized that a decreased ability to ... [more ▼]

Variable numbers of CD34(+) cells can be harvested from the blood of AML patients in CR after G-CSF supported mobilization following consolidation chemotherapy. We hypothesized that a decreased ability to mobilize stem cells reflects a chemotherapy-induced reduction in the number of normal and leukemic stem cells. We therefore analyzed whether the mobilizing capacity of these patients was of prognostic significance. 342 AML-patients in first CR received daily G-CSF from day 20 of the consolidation course and underwent 1-6 aphereses to obtain a minimum dose of 2 x 10(6) CD34(+) cells/kg. Afterwards they were randomized for autologous bone marrow (M) or blood SCT. As a surrogate marker for the mobilizing capacity, the highest yield of CD34(+) cells of a single apheresis was adopted. Patients could be categorized into four groups: no harvest (n = 76), low yield (<1 x 10(6) CD34(+)/kg; n = 50), intermediate yield (1-6.9 x 10(6) CD34(+) cells/kg; n = 128) and high yield ( :7 x 106 CD34+ cells/kg; n = 88). The median follow-up was 3.4 years; 163 relapses and 16 deaths in CR were reported. Autologous blood or BM SCT was performed in 36%, 64%, 81% and 88%, respectively, of the patients assigned to the no harvest, low, intermediate and high CD34(+) yield group. The 3-year disease-free survival rate was 46.7%, 65.0%, 50.4% and 26.9% (P= 0.0002) and the relapse incidence was 47.5%, 30.1%, 43.1% and 71.9% (P < 0.0001). Multivariate Cox's proportional hazards model showed that the CD34(+) yield was the most important independent prognostic variable (P = 0.005) after cytogenetics. Patients with the highest mobilizing capacity have a poor prognosis due to an increased relapse incidence. [less ▲]

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See detailPhenomenal characteristics of cryptomnesia
Brédart, Serge ULg; Lampinen, J. M.; Defeldre, A. C.

in Memory (2003), 11(1), 1-11

Qualitative characteristics of cryptomnesia, or unintentional plagiarism were investigated. In Experiment I we compared accurate and inaccurate source attributions in terms of their level of confidence ... [more ▼]

Qualitative characteristics of cryptomnesia, or unintentional plagiarism were investigated. In Experiment I we compared accurate and inaccurate source attributions in terms of their level of confidence using instructions that did not require a fixed number of responses. Confidence was lower for plagiarised responses than for correct responses. Nevertheless, participants provided high ratings of certainty for a large proportion of their plagiarised responses. In Experiment 2 the phenomenological differences between plagiarised recall and veridical recall were compared by using an adaptation of the memory characteristics questionnaire (Johnson, Foley, Suengas, [less ▲]

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See detailSafe treatment of thiopurine S-methyltransferase deficient Crohn's disease patients with azathioprine
Kaskas, B. A.; Louis, Edouard ULg; Hindorf, U. et al

in Gut (2003), 52(1), 140-142

Thiopurine S-methyltransferase (TPMT) deficient patients develop life threatening haematoxicity (for example, pancytopenia) when treated with a standard dose of azathioprine (AZA) and 6-mercaptopurine (6 ... [more ▼]

Thiopurine S-methyltransferase (TPMT) deficient patients develop life threatening haematoxicity (for example, pancytopenia) when treated with a standard dose of azathioprine (AZA) and 6-mercaptopurine (6-MP) due to excessive accumulation of cytotoxic metabolites. At present, it is generally recommended that these patients should not receive AZA or 6-MP treatment for inflammatory bowel disease. We report for the first time that Crohn's disease patients with TPMT deficiency can be successfully treated with AZA. We illustrate this with three cases where treatment has been successful and toxicity has been avoided by carefully titrating the drug dose. Thus very low TPMT activity demands pharmacogenetically guided dosing. [less ▲]

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See detailLa détention et l'expulsion collective des étrangers. Commentaire de l'affaire Conka
Carlier, Jean-Yves ULg

in Revue Trimestrielle des Droits de l'Homme [= RTDH] (2003), 14(53), 198-222

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See detailUtilisation des pesticides dans le contexte de la production de fruits et légumes exportés
Schiffers, Bruno ULg

Scientific conference (2003, January)

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See detailANGULAR DEPENDENT VORTEX DYNAMICS IN SUPERCONDUCTORS WITH COLUMNAR DEFECTS
Civale, L.; Silhanek, Alejandro ULg; Pasquini, G.

in Narlikar, Anant (Ed.) Irradiation effects and cationinc disorder in HTS (2003)

This book chapter described the vortex pinning properties of type II superconductors with columnar defects by means of magnetization and ac-susceptibility measurements.

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