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See detailExamination of Escherichia coli from poultry for selected adhesin genes important in disease caused by mammalian pathogenic E. coli
Stordeur, Philippe; Marlier, Didier ULg; Blanco, J. et al

in Veterinary Microbiology (2002), 84(3), 231-241

A collection of 1601 extraintestinal and intestinal Escherichia coli isolated from chickens, turkeys and ducks. in Belgium, France and Spain, was hybridised with gene probes specific for fimbrial and ... [more ▼]

A collection of 1601 extraintestinal and intestinal Escherichia coli isolated from chickens, turkeys and ducks. in Belgium, France and Spain, was hybridised with gene probes specific for fimbrial and afimbrial adhesins (F17, F18, S (Sfa/F1C), Bfp, Afa, Cs31A, Intimin (Eae), Aida-1) of intestinal, urinary and invasive E. coli of mammals and with a probe specific for the P (Pap/Prs) fimbrial adhesin of urinary and invasive E. coli of mammals and birds. Three hundred and eighty-three strains (23.9%) were P-positive, 76 strains (4.8%) were Afa-positive, 75 strains (4.7%) were F17-positive, 67 strains (4.2%) were S-positive, 23 (1.4%) were Intimin-positive. and all were F18-, Cs31A-, Aidal- and Bfp-negative. The 75 F17-positive strains harboured different major subunit A-encoding gene variants, but the f17Ac variant was the most frequent (52 strains, 69,3%) and seven strains (9.3%) were not typeable. The f17G gene variant coding for the GII adhesin was the most frequent (56 strains, 75.0%), whereas the f17GI gene variant was present in four strains (5%) and 15 strains (20.0%) were not typeable. All Afa-positive strains harboured the afa-8 variant. The 23 Intimin-positive E. coli tested positive for the beta -variant (16 strains; 69.6%) or for the gamma -variant (seven strains;, 30.4%) of the eae gene. Chicken and turkey E. coli were more frequently probe-positive (43.6 and 43.1 %, respectively) than duck E. coli 31.5%) and extraintestinal E. coli were also more frequently probe-positive (48.4%) than intestinal strains (18.5%). Different combinations of probe positive hybridisation results were observed in 72 of the 540 probe-positive E. coli (13.3%). The most frequent combinations were between AfaE-8 and F17 probes (47 strains; 8.7%) and between P and S probes (13 strains. 2.4%). Although f17- and afa-8-related DNA sequences can be plasmid-located in mammalian E. coli. they were not in avian E. coli. Besides the P fimbrial adhesin, F17 and S fimbrial and Afa-VIII and Intimin afimbrial adhesins may thus represent colonisation factors of avian pathogenic E. coli. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailReplicon typing of the F18 fimbriae encoding plasmids of enterotoxigenic and verotoxigenic Escherichia coli strains from porcine postweaning diarrhoea and oedema disease
Fekete, PZs; Gérardin, J.; Jacquemin, E. et al

in Veterinary Microbiology (2002), 85

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See detailDNA sequences coding for the F18 fimbriae and AIDA adhesin are localized on the same plasmid in Escherichia coli isolates from piglets
Mainil, Jacques ULg; Jacquemin, E.; Pohl, P. et al

in Veterinary Microbiology (2002), 86

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See detailLa guerre et la médecine d'une culture de paix. 3. Synopsis des armes chimiques.
Pierard, Gérald ULg

in Revue Médicale de Liège (2002), 57(1), 49-52

A variety of chemical components can be used as warfare threats directly targeting humans. They can be classified according to their main biological effects as nerve agents, vesicants, lung damaging ... [more ▼]

A variety of chemical components can be used as warfare threats directly targeting humans. They can be classified according to their main biological effects as nerve agents, vesicants, lung damaging agents, cyanogen agents and incapacitants. Other chemical agents are water and food contaminants. Still other less aggressive compounds are mainly used to control riots. Smokes, flame materials and herbicides belong to other classes of chemical agents of the warlike armamentum exhibiting a direct effect on man. [less ▲]

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See detailDaily management of the transition to the future.
Goffinet, Nathalie ULg; Delvenne, Catherine ULg; Chalon, Patrice ULg et al

in Proceedings of the 8th European Conference of medical and Health Libraries, Köln, Septembre 16-21, 2002. (2002)

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See detailLes bancs solaires au banc des accusés.
Uhoda, I.; Petite, Louicette ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2002), 57(1), 29-32

Sunbeds used in sun parlours do not garantee a controlled innocuity. By contrast, health hazards are obvious in many instances. Forceful tanning is a transitory aspect behind which the spectrum of many ... [more ▼]

Sunbeds used in sun parlours do not garantee a controlled innocuity. By contrast, health hazards are obvious in many instances. Forceful tanning is a transitory aspect behind which the spectrum of many skin changes includes accelerated photoageing, irreversible pigmentary and keratotic changes, and cutaneous malignancies including malignant melanoma. In the absence of protection, the eye is also affected. Even if tanning salon exposure increases the risk for skin cancer by a small amount, it represents a significant potential public health hazard given the number of people attending salons. Digital dermoscopy and ultraviolet light videoscopy are new methods allowing to predict the cutaneous ransom to be paid by the sunbed worshippers. [less ▲]

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See detailPharma clinics. Comment je traite ... un herpes labial récurrent.
Petit, L.; Braham, C.; Nikkels, Arjen ULg et al

in Revue Médicale de Liège (2002), 57(2), 67-71

Recurrent herpes labialis is a frequent disorder. It occurs following the reactivation of the Herpesvirus (HSV1 and more rarely HSV2) inside the Gasser ganglion. Treatment and prevention of recurrent ... [more ▼]

Recurrent herpes labialis is a frequent disorder. It occurs following the reactivation of the Herpesvirus (HSV1 and more rarely HSV2) inside the Gasser ganglion. Treatment and prevention of recurrent labial herpes are targeted by specific antiviral agents. Spectacular benefits obtained in the immunocompromised patients are less convincing in otherwise healthy subjects. Other prospective ways of therapy are under consideration, including lipopeptides and physical means aiming at modifying the cutaneous pH. [less ▲]

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See detailLa guerre et la médecine d'une culture de paix. 4. Synopsis des armes nucléaires.
Pierard, Gérald ULg

in Revue Médicale de Liège (2002), 57(2), 107-12

The nuclear weapons have a terrifying power of devastation. A civilian nuclear accident has its own dramatic consequences. Both situations are, however, totally distinct with regard to medical ... [more ▼]

The nuclear weapons have a terrifying power of devastation. A civilian nuclear accident has its own dramatic consequences. Both situations are, however, totally distinct with regard to medical consequences. The Gulf war and Balkan war syndromes might be in part caused by uranium used in conventional amunitions. The risk of nuclear terrorism is an emerging eventuality. [less ▲]

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See detailL'image du mois. Une onychopathie ponctuée en dé a coudre.
Perotti-Abad, M. J.; Arrese Estrada, Jorge ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2002), 57(3), 129-30

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See detailLa guerre et la médecine d'une culture de paix. 5. Synopsis des armes non létales.
Pierard, Gérald ULg

in Revue Médicale de Liège (2002), 57(3), 176-8

Non lethal weapons may be harmful for people. The effects are accidental in some instances. For some weapons, they are clearly intentional. The eventuality of a fatal issue cannot be ruled out.

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See detailComment j'explore.... Une sclérodermie cutanée d'une manière non invasive.
Fraiture, A. L.; Henry, Frédérique ULg; Goffin, Véronique ULg et al

in Revue Médicale de Liège (2002), 57(3), 179-82

There exists several clinical types of scleroderma. Most of them show cutaneous manifestations. Skin involvement may be isolated (morphea) or be part of a multi-organ systemic disease. Objective non ... [more ▼]

There exists several clinical types of scleroderma. Most of them show cutaneous manifestations. Skin involvement may be isolated (morphea) or be part of a multi-organ systemic disease. Objective non-invasive functional methods are useful in order to better assess the severity and evolution of the disease and the effects of treatments. Measurements of the thickness and mechanical properties of the skin as well as the visualization of the cutaneous blood flow prove to be informative. [less ▲]

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See detailPrenons garde aux lésions kystiques cutanées. Du dérisoire au méritoire.
Hermanns-Le, Trinh ULg; Hermanns, Jean-François ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2002), 57(5), 314-6

Cutaneous cystic-like lesions do not always correspond to real epithelial cysts. Indeed, the histological examination may identify another benign tumour. But, in some instances, the surprise may be ... [more ▼]

Cutaneous cystic-like lesions do not always correspond to real epithelial cysts. Indeed, the histological examination may identify another benign tumour. But, in some instances, the surprise may be greater. We report three patients in whom lesions suggested clinically small cysts. However, they were malignant neoplasms corresponding to a malignant fibrous histiocytoma, an epithelioid angiosarcoma and a metastatic adenocarcinoma, respectively. [less ▲]

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See detailUne allergie conjugale exacerbée: les dermatoses par procuration.
Martalo, O.; Fraiture, A. L.; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2002), 57(5), 320-3

A young woman presented two distinct vesiculobullous dermatoses sharing in common her husband's imputability. She suffered from contact dermatitis due to colophony used by her husband who was violinist ... [more ▼]

A young woman presented two distinct vesiculobullous dermatoses sharing in common her husband's imputability. She suffered from contact dermatitis due to colophony used by her husband who was violinist. During her second pregnancy, pemphigoid gestationis was diagnosed. This autoimmune disease is directed to the father's HLA class II present on the placenta. The same antibodies also interact with the dermo-epidermal junction in the mother where they induce blisters. [less ▲]

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See detailComment je traite.... Un pityriasis rubra pilaire.
Fraiture, A. L.; Braham, C.; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2002), 57(6), 363-5

Pityriasis rubra pilaris is a syndrome of unknown etiology. Six distinct clinical types have been described in infancy and adulthood. Oral retinoids have proven their efficacy. Emollients and topical ... [more ▼]

Pityriasis rubra pilaris is a syndrome of unknown etiology. Six distinct clinical types have been described in infancy and adulthood. Oral retinoids have proven their efficacy. Emollients and topical calcipotriol may improve the clinical presentation. [less ▲]

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See detailComment j'explore ... une métastase orpheline d'un mélanome.
Henry, Frédérique ULg; Pierard, Claudine ULg; Arrese Estrada, Jorge ULg et al

in Revue Médicale de Liège (2002), 57(6), 405-7

A presumed melanoma metastasis is sometimes found without any evidence for the primary neoplasm. Such an orphan metastasis merits a complementary exploration. Searching for the primary melanoma must then ... [more ▼]

A presumed melanoma metastasis is sometimes found without any evidence for the primary neoplasm. Such an orphan metastasis merits a complementary exploration. Searching for the primary melanoma must then be performed using non invasive and clinically oriented methods. Beside a thorough skin examination, otorhinolaryngological, ophtalmic and gynecologic searches are recommended. In addition, paraclinical investigations are conducted according to the metastatic location, the gender and the functional complaints of the patient. The prognosis of these orphan metastases is not more dramatic than when the primary lesion is identified. Therapies are similar to those proposed in the classical presentation of the disease. [less ▲]

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See detailL'image du mois. Sclérose tubéreuse de Bourneville.
Garcia, Roy; Arrese Estrada, Jorge ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2002), 57(7), 425-7

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See detailDHEA et intracrinologie de jouvence pour la peau? Entre raison et magie.
Bourguignon, Raphael; Uhoda, I.; Henry, Frédérique ULg et al

in Revue Médicale de Liège (2002), 57(7), 438-42

Slowing down ageing is a goal for a large part of the population. Some mercantile claims hold out bright prospects to DHEA. The effects of this hormone manifest themselves after intracrine conversion. In ... [more ▼]

Slowing down ageing is a goal for a large part of the population. Some mercantile claims hold out bright prospects to DHEA. The effects of this hormone manifest themselves after intracrine conversion. In the skin, sebaceous glands enlarge and seborrhoea increases in post-menopausal women. No other effect is clinically discernable on the skin. At this level, DHEA does not show efficacy comparable to that of other anti-ageing compounds. [less ▲]

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See detailPrévention des cancers cutanés par les crèmes de protection solaire.
Uhoda, I.; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2002), 57(8), 505-8

How do sunscreens protect against skin cancers? The answer to this question is a matter of controversy among scientist for several years. The doubt persists because the wise use of such products is only ... [more ▼]

How do sunscreens protect against skin cancers? The answer to this question is a matter of controversy among scientist for several years. The doubt persists because the wise use of such products is only one of the factors involved in sun behavior together with avoiding excessive sunlight exposure and wearing protective clothes. [less ▲]

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See detailLe médicament du mois. Le tacrolimus topique (Protopic).
Pierard, Gérald ULg; Pierard, Claudine ULg; Paquet, Philippe ULg

in Revue Médicale de Liège (2002), 57(8), 552-5

Tacrolimus is a potent inhibitor of immune mechanisms. It belongs to the macrolactam group. It inhibits the release of both Th1 and Th2 cytokines. It proves to be efficacious after topical application in ... [more ▼]

Tacrolimus is a potent inhibitor of immune mechanisms. It belongs to the macrolactam group. It inhibits the release of both Th1 and Th2 cytokines. It proves to be efficacious after topical application in the treatment of atopic dermatitis. In this indication, tacrolimus challenges topical corticosteroids. Irritation risks are present. The local immuno-depression can boost disseminated infections including herpes. The risk to promote photocarcinogenesis on the long term, and that bound to chronic resorption remain theoretical concerns that have not been assessed so far. [less ▲]

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See detailStaging of regional nodes in AJCC stage I and II melanoma: 18FDG PET imaging versus sentinel node detection.
Belhocine, Tarik; Pierard, Gérald ULg; De Labrassinne, Michel et al

in Oncologist (2002), 7(4), 271-8

PRIMARY PURPOSE: The staging of regional nodes by means of sentinel node detection has been shown to accurately detect subclinical nodal metastases from cutaneous melanoma. On the other hand, the ... [more ▼]

PRIMARY PURPOSE: The staging of regional nodes by means of sentinel node detection has been shown to accurately detect subclinical nodal metastases from cutaneous melanoma. On the other hand, the oncological applications of 18F-fluoro-2-deoxy-D-glucose positron emission tomography (18FDG PET) are, nowadays, firmly established. However, the sensitivity of such metabolic imaging for staging the regional nodes in primary melanoma remains debatable. We prospectively assessed the actual value of PET for detecting sentinel node metastases in 21 consecutive patients presenting with early-stage melanoma. MATERIALS AND METHODS: Twenty-one melanoma patients scheduled for lymphatic mapping and sentinel lymphadenectomy underwent fully corrected whole-body PET using 18FDG. In all cases, the disease was initially classified as either stage I or II, from the latest version of the American Joint Committee on Cancer staging system. The sentinel node detection was systematically performed within the week following the PET scan. Serial sections of the sentinel nodes were analyzed by both conventional pathology and immunohistochemical staining. Metastatic sentinel nodes were also assessed for the size of tumor deposits and the degree of nodal involvement (focal, partial, or massive). The median follow-up time was 12 months. RESULTS: Six of the 21 patients (28.5%) had an involved sentinel node. PET was positive in only one case with a sentinel node >1 cm. In the five other cases, the sentinel nodes missed by PET were <1 cm with focal and/or partial involvements. One patient, free of regional nodal metastases in both sentinel node detection and PET imaging, had, however, a same-basin recurrence 3 months later. In another case, PET had one false positive result. Overall, the sentinel detection of subclinical nodal metastases had a sensitivity of 86%. PET detected only 14% of sentinel node metastases. CONCLUSIONS: Sentinel node detection remains the procedure of choice for detecting subclinical lymph node involvement from primary cutaneous melanoma. Owing to its limited spatial resolution, PET appears insufficiently sensitive to identify microscopic nodal metastases. As a practical consequence, metabolic imaging is not recommended as a first-line imaging strategy for staging regional lymph nodes in patients with stage I or II melanoma. [less ▲]

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