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See detailFactors that influence physicians' detection of distress in patients with cancer - Can a communication skills training program improve physicians' detection?
Merckaert, Isabelle; Libert, Yves; Delvaux, Nicole et al

in Cancer (2005), 104(2), 411-421

BACKGROUND. No study to date has assessed the impact of skills acquisition after a communication skills training program on physicians' ability to detect distress in patients with cancer. METHODS. First ... [more ▼]

BACKGROUND. No study to date has assessed the impact of skills acquisition after a communication skills training program on physicians' ability to detect distress in patients with cancer. METHODS. First, the authors used a randomized design to assess the impact, on physicians' ability to detect patients' distress, of a 1-hour theoretical information course followed by 2 communication skills training programs: a 2.5-day basic training program and the same training program consolidated by 6 3-hour consolidation workshops. Then, the investigate contextual, patient, and communication variables or factors associated with physicians' detection of patients' distress were investigated. After they attended the basic communication skills training program, physicians were assigned randomly to consolidation workshops or to a waiting list. Interviews with a cancer patient were recorded before training, after consolidation workshops for the group that attended consolidation workshops, and approximate to 5 months after basic training for the group that attended basic training without the consolidation workshops. Patient distress was recorded with the Hospital Anxiety and Depression Scale before the interviews. Physicians rated their patients' distress on a visual analog scale after the interviews. Physicians' ability to detect patients' distress was measured through computing differences between physicians' ratings of patients' distress and patients' self-reported distress. Communication skills were analyzed according to the Cancer Research Campaign Workshop Evaluation Manual. RESULTS. Fifty-eight physicians were evaluable. Repeated -measures analysis of variance showed no statistically significant changes over time and between groups in physicians' ability to assess patient distress. Mixed-effects modeling showed that physicians' detection of patients' distress was associated negatively with patients' educational level (P = 0.042) and with patients' self-reported distress (P < 0.000). Mixed-effects modeling also showed that physicians' detection of patient distress was associated positively with physicians breaking bad news (P = 0.022) and using assessment skills (P = 0.015) and supportive skills (P = 0.045). CONCLUSIONS. Contrary to what was expected, no change was observed in physicians' ability to detect distress in patients with cancer after a communication skills training programs, regardless of whether physicians attended the basic training program or the basic training program followed by the consolidation workshops. The results indicated a need for further improvements in physicians' detection skills through specific training modules, including theoretical information about factors that interfere with physicians' detection and through role-playing exercises that focus on assessment and supportive skills that facilitate detection. (c) 2005 American Cancer Society. [less ▲]

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See detailBulletin agrométéorologique - Juin 2005
Tychon, Bernard ULg; Ozer, Pierre ULg; De Longueville, Florence ULg et al

in Bulletin Agrométéorologique (2005), 4(3), 6

Tous les paramètres climatiques furent anormaux à exceptionnels par rapport à la moyenne durant le mois de juin. Aussi, les prévisions de rendements de principales cultures sont globalement à la baisse ... [more ▼]

Tous les paramètres climatiques furent anormaux à exceptionnels par rapport à la moyenne durant le mois de juin. Aussi, les prévisions de rendements de principales cultures sont globalement à la baisse sur le territoire. [less ▲]

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See detailLe G8 ou la Guerre des Mondes
Ozer, Pierre ULg; Balthasar, Jean Pierre

Article for general public (2005)

Les inconditionnels de Steven Spielberg, les passionnés de science fiction et les fans de Tom Cruise comptent les minutes. C'est ce mercredi que sort dans les salles obscures le très attendu « La Guerre ... [more ▼]

Les inconditionnels de Steven Spielberg, les passionnés de science fiction et les fans de Tom Cruise comptent les minutes. C'est ce mercredi que sort dans les salles obscures le très attendu « La Guerre des Mondes » dont les affiches promotionnelles tapissent nos villes depuis deux semaines déjà. La bande annonce nous met en appétit : « Préparez-vous pour un événement qui va changer le monde ». [...] [less ▲]

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See detailRôle des protéinases et de leurs inhibiteurs dans les formes associées à une néovascularisation anormale sous-rétinienne. Caractérisation par l’étude de modèles animaux transgéniques et développements thérapeutiques.
Lambert, Vincent ULg

Doctoral thesis (2005)

La dégénérescence maculaire liée à l'âge (DMLA) est la principale cause de perte visuelle chez les personnes de plus de 70 ans dans le monde occidental. Cette cécité résulte de la perte de fonction de la ... [more ▼]

La dégénérescence maculaire liée à l'âge (DMLA) est la principale cause de perte visuelle chez les personnes de plus de 70 ans dans le monde occidental. Cette cécité résulte de la perte de fonction de la macula (au centre de la rétine) qui est responsable de la vision centrale. Cette dégénérescence réprésente un handicap social indéniable et une perte de liberté pour ces personnes atteintes, car elle affecte des activités telles que la conduite, la lecture ou tout simplement la reconnaissance d’un visage. La pathogénie de cette affection est complexe et peu comprise. La forme la plus grave de cette maladie est associée à une poussée vasculaire (angiogenèse) vers l'espace sous-rétinien qui entraîne une fibrose avec perte des photorécepteurs. La plupart des lésions ne sont pas curables par photocoagulation laser et les stratégies thérapeutiques actuelles sont insuffisantes. Nous avons étudié, dans notre laboratoire, les mécanismes moléculaires de l’angiogenèse. Ce processus invasif requiert la digestion de la matrice extracellulaire avant la prolifération et la migration des capillaires. Deux systèmes enzymatiques sont principalement impliqués dans la digestion tissulaire : le système plasminogène/plasmine et les métalloprotéinases matricielles (MMPs). 1) Le système protéolytique activateur du plasminogène/plasmine : Afin d'évaluer la pertinence biologique de ce système dans l'angiogenèse sous-rétinienne, nous avons mis au point un modèle de néovascularisation choroidienne à l'aide d'un impact laser à l'argon chez des souris déficientes pour une série de gènes fondamentaux de ce système, comparées à des souris normales. Nos observations mettent en évidence le rôle essentiel du PAI-1 dans la néovascularisation sous-rétinienne et contribuent à expliquer l'aspect multifonctionnel du PAI-1 dans l'angiogenèse. 2) Les métalloprotéinases matricielles (MMPs) : Les métalloprotéinases matricielles (MMPs) participent au remodelage normal tissulaire et sont impliquées dans un large éventail de phénomènes physiologiques et pathologiques, tels que l'invasion cellulaire tumorale, la cicatrisation et l'angiogenèse. Nous avons appliqué notre modèle expérimental à des souris déficientes pour deux types de MMP (MMP-2 et MMP-9). La déficience en MMP-2 et -9 inhibe la néovascularisation sous-rétinienne induite par laser, soulignant l’importance de cette enzyme in vivo. Ces études laissent entrevoir des perspectives thérapeutiques dans la lutte contre la DMLA par l’utilisation d’inhibiteur spécifiques des ces MMPs. En conclusion, ces différents aspects de notre étude ouvrent des perpectives de développements thérapeutiques. Ils démontrent l’importance des MMP-2, MMP-9 et de PAI-1 dans la néovascularisation sous-rétinienne. L’inhibition spécifique de ces enzymes laisse entrevoir des espoirs dans le traitement curatif de la dégénérescence maculaire liée à l’âge. Malheureusement de grandes lacunes existent encore quand aux perturbations métaboliques à l’origine de la DMLA, ce qui est l’objet de cette étude. [less ▲]

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See detailMulti-frequency nonlinear energy transfer from linear oscillators to mdof essentially nonlinear attachments
Tsakirtzis, Stylianos; Kerschen, Gaëtan ULg; Panagopoulos, Panagiotis et al

in Journal of Sound & Vibration (2005), 285(1-2), 483-490

We report on multi-frequency energy transfer from a two-mode, initially excited linear system to a multi-degree-of-freedom (mdof) essentially nonlinear attachment. This occurs through simultaneous ... [more ▼]

We report on multi-frequency energy transfer from a two-mode, initially excited linear system to a multi-degree-of-freedom (mdof) essentially nonlinear attachment. This occurs through simultaneous resonance interactions of both linear modes with a set of nonlinear normal modes (NNMs) of the attachment, and is studied utilizing numerical wavelet transforms. The multi-frequency nonlinear energy transfer discussed herein differs from multi-frequency energy transfer caused by resonance capture cascading where sequential energy transfer from a set of linear modes to single-dof nonlinear attachments takes place. (c) 2004 Elsevier Ltd. All rights reserved. [less ▲]

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See detailEtude du classement par forêts aléatoires d'échantillons perturbés à forte structure d'interaction
Brostaux, Yves ULg

Doctoral thesis (2005)

Amongst classification methods, forests of decision trees (Random Forests, BREIMAN, 2001) are highly versatile concerning descriptive attributes' or target variable's nature and shape of the concept to ... [more ▼]

Amongst classification methods, forests of decision trees (Random Forests, BREIMAN, 2001) are highly versatile concerning descriptive attributes' or target variable's nature and shape of the concept to estimate. Their diffusion in agronomical sciences is slowed by a lack of information about their ability to learn models with high interaction structures using learning samples with few examples and affected by random noise and irrelevant attributes. This research aim to fill this gap by a systematic exploration of those factors' effects and of the parameters of the Random Forests method, which is done by computer simulations, taking as a reference the classification trees generated by Breiman's CART method (1984). Results show that generating random forests with a partially deterministic attributes selection and a forest size of at least 100 or 500 trees give the best prediction accuracy. Those random forests show a significant increase in prediction accuracy on CART trees, even for low learning sample size (50 examples). This advantage reduce with the global perturbation level (noise and irrelevant attributes) but increase with the learning sample size, as random forests aren't affected by the asymptotic limitation of the learning curve showed by CART method. [less ▲]

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See detailLiving radical polymerization under emulsion conditions
Szkurhan, K.; Chan-Seng, D.; Kasahara, T. et al

Poster (2005, July 03)

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See detailComet C/2005 K2 (LINEAR)
Jehin, Emmanuel ULg; Nielsen, O.; Bryssinck, E.

in International Astronomical Union Circulars [=IAUCs] (2005), 8566

IAUC 8566 available at Central Bureau for Astronomical Telegrams.

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See detailYin Yang 1 cooperates with activator protein 2 to stimulate ERBB2 gene expression in mammary cancer cells.
Begon, Dominique ULg; Delacroix, Laurence ULg; Vernimmen, Douglas et al

in Journal of Biological Chemistry (2005), 280(26), 24428-34

Overexpression of the ERBB2 oncogene is observed in about 30% of breast cancers and is generally correlated with a poor prognosis. Previous results from our and other laboratories indicated that elevated ... [more ▼]

Overexpression of the ERBB2 oncogene is observed in about 30% of breast cancers and is generally correlated with a poor prognosis. Previous results from our and other laboratories indicated that elevated transcriptional activity contributes significantly to the overexpression of ERBB2 mRNA in mammary adenocarcinoma cell lines. Activator protein 2 (AP-2) transcription factors account for this overexpression through two recognition sequences located 215 and 500 bp upstream from the transcription start site. Furthermore, AP-2 transcription factors are highly expressed in cancer cell lines overexpressing ERBB2. In this report, we examined the cooperative effect of Yin Yang 1 (YY1) on AP-2-induced activation of ERBB2 promoter activity. We detected high levels of YY1 transcription factor in mammary cancer cell lines. Notably, we showed that YY1 enhances AP-2alpha transcriptional activation of the ERBB2 promoter through an AP-2 site both in HepG2 and in HCT116 cells, whereas a carboxyl-terminal-truncated form of YY1 cannot. Moreover, we demonstrated the interaction between endogenous AP-2 and YY1 factors in the BT-474 mammary adenocarcinoma cell line. In addition, inhibition of endogenous YY1 protein by an antisense decreased the transcription of an AP-2-responsive ERBB2 reporter plasmid in BT-474 breast cancer cells. Finally, we detected in vivo AP-2 and YY1 occupancy of the ERBB2 proximal promoter in chromatin immunoprecipitation assays. Our data thus provide evidence that YY1 cooperates with AP-2 to stimulate ERBB2 promoter activity through the AP-2 binding sites. [less ▲]

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See detailCritical specific stream power in gravel-bed rivers
Petit, François ULg; Gob, Frédéric ULg; Houbrechts, Geoffrey ULg et al

in Geomorphology (2005), 69(1-4), 92-101

Experiments with marked pebbles were carried out on different sized rivers of the Belgian Ardenne (catchment areas varying from less than I km(2) to 2700 km(2)). Specific stream power required to cause ... [more ▼]

Experiments with marked pebbles were carried out on different sized rivers of the Belgian Ardenne (catchment areas varying from less than I km(2) to 2700 km(2)). Specific stream power required to cause bedload movement was evaluated and critical values were obtained. Three types of relationship between critical specific stream power (omega(0)) and grain size (D) were established. The values for coo in the largest river (the Ourthe) were the lowest and were close to the values obtained for mountainous rivers carrying large boulders. In medium sized rivers (catchment area between 40 and 500 km(2)), the critical unit stream power was higher. It is likely that it is due to the bedform's greater resistance. This resistance would use up some of the energy that can cause movement and transport of bedload. The amount of resistance of the bedform can be expressed as bedform shear stress (tau ''), determined by the relationship between grain shear stress (tau'-that determines movement and transport of the bedload) and the total shear stress (tau). This ratio varies between 0.4 and 0.5 in the medium sized rivers, compared to 0.7 in the Ourthe. In headwater streams (less than 20 km(2)), there is greater loss of energy due to bedform resistance (tau'/tau < 0.3). Critical specific stream power is higher in this third type of river than in the other two. (c) 2005 Elsevier B.V. All rights reserved. [less ▲]

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See detailSurface effects of active folding, illustrated with examples from the TianShan
Hubert, Aurelia ULg; Suppe, J; Gonzalez-Mieres, J. et al

Conference (2005, July)

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See detailExperience from a large multi-centre expanded access programme (EAP) with gefitinib ('Iressa', ZD1839) as monotherapy in advanced non-small cell lung cancer (NSCLC)
van Puijenbroek, R.; Bosquee, Léon ULg; Tits, G. et al

in Lung Cancer (2005, July), 49(Suppl. 2), 273

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See detailTopology Discovery Using an Address Prefix Based Stopping Rule
Donnet, Benoît ULg; Friedman, Timur

in EUNICE Workshop (2005, July)

Recently, a first step towards a highly distributed IP-level topology discovery tool has been made with the introduction of the Doubletree algorithm. Doubletree is an efficient cooperative algorithm that ... [more ▼]

Recently, a first step towards a highly distributed IP-level topology discovery tool has been made with the introduction of the Doubletree algorithm. Doubletree is an efficient cooperative algorithm that allows the discovery of a large portion of nodes and links in the network while strongly reducing probing redundancy on nodes and destinations as well as the amount of probes sent. In this paper, we propose to reduce more strongly the load on destinations and, more essentially, the communication cost required for the cooperation by introducing a probing stopping rule based on CIDR address prefixes. [less ▲]

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See detailLow-Molecular-Weight Protein Tyrosine Phosphatases of Bacillus subtilis
Musumeci, Lucia ULg; Bongiorni, Cristina; Tautz, Lutz et al

in Journal of Bacteriology (2005), 187(14), 4945-4956

In gram-negative organisms, enzymes belonging to the low-molecular-weight protein tyrosine phosphatase (LMPTP) family are involved in the regulation of important physiological functions, including stress ... [more ▼]

In gram-negative organisms, enzymes belonging to the low-molecular-weight protein tyrosine phosphatase (LMPTP) family are involved in the regulation of important physiological functions, including stress resistance and synthesis of the polysaccharide capsule. LMPTPs have been identified also in gram-positive bacteria, but their functions in these organisms are presently unknown. We cloned two putative LMPTPs from Bacillus subtilis, YfkJ and YwlE, which are highly similar to each other in primary structure as well as to LMPTPs from gram-negative bacteria. When purified from overexpressing Escherichia coli strains, both enzymes were able to dephosphorylate p-nitrophenyl-phosphate and phosphotyrosine-containing substrates in vitro but showed significant differences in kinetic parameters and sensitivity to inhibitors. Transcriptional analyses showed that yfkJ was transcribed at a low level throughout the growth cycle and underwent a σB-dependent transcriptional upregulation in response to ethanol stress. The transcription of ywlE was growth dependent but stress insensitive. Genomic deletion of each phosphatase-encoding gene led to a phenotype of reduced bacterial resistance to ethanol stress, which was more marked in the ywlE deletion strain. Our study suggests that YfkJ and YwlE play roles in B. subtilis stress resistance. [less ▲]

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See detailThe antiangiogenic factor, 16-kDa human prolactin, induces endothelial cell cycle arrest by acting at both the G(0)-G(1) and the G(2)-M phases
Tabruyn, Sébastien ULg; Nguyen, Ngoc-Quynh-Nhu ULg; Cornet, Anne ULg et al

in Molecular Endocrinology (2005), 19(7), 1932-1942

The 16-kDa N-terminal fragment of human prolactin (16K hPRL) is a potent antiangiogenic factor that has been shown to prevent tumor growth in a xenograph mouse model. In this paper we first demonstrate ... [more ▼]

The 16-kDa N-terminal fragment of human prolactin (16K hPRL) is a potent antiangiogenic factor that has been shown to prevent tumor growth in a xenograph mouse model. In this paper we first demonstrate that 16K hPRL inhibits serum-induced DNA synthesis in adult bovine aortic endothelial cells. This inhibition is associated with cell cycle arrest at both the G(0)-G(1) and the G(2)-M phase. Western blot analysis revealed that 16K hPRL strongly decreases levels of cyclin D1 and cyclin B1, but not cyclin E. The effect on cyclin D1 is at least partially transcriptional, because treatment with 16K hPRL both reduces the cyclin D1 mRNA level and down-regulates cyclin D1 promoter activity. This regulation may be due to inhibition of the MAPK pathway, but it is independent of the glycogen synthase kinase-3 beta pathway. Lastly, 16K hPRL induces the expression of negative cell cycle regulators, the cyclin-dependent kinase inhibitors p21(cip1) and p27(kip1). In summary, 16K hPRL inhibits serum-induced proliferation of endothelial cells through combined effects on positive and negative regulators of cell cycle progression. [less ▲]

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See detailOptimization of Surface Utilization Using Heuristic Approaches
Langer, Yves; Bay, Maud ULg; Crama, Yves ULg et al

in Ship Technology Research = Schiffstechnik (2005), 52(3), 141-147

We present a scheduling problem that arises in factories producing large building blocks. This is a three dimensional bin-packing problem with two spatial dimensions and a time dimension. We propose an ... [more ▼]

We present a scheduling problem that arises in factories producing large building blocks. This is a three dimensional bin-packing problem with two spatial dimensions and a time dimension. We propose an algorithm based on the guided local search heuristic of Faroe and al. (Informs Journal of Computing,vol.15, 2003). The algorithm is especially developped to consider real-life issues. Finally the algorithm is applied on an industrial problem and shows excellent performances in speed and quality of the solution. [less ▲]

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See detailEfficacy and morbidity of a novel induction treatment for locally advanced NSCLC
Bosquee, Léon ULg; Rinken, Françoise ULg; Bustin, F. et al

in Lung Cancer (2005, July), 49(Suppl. 2), 78

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See detailDétestation de la mélancolie. Note sur la mémoire et sur l'oubli
Havelange, Carl ULg

in vu d'ici (2005), 19

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