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See detailThe varicella-zoster virus immediate-early 63 protein affects chromatin-controlled gene transcription in a cell-type dependent manner.
Habran, Lionel ULg; El Mjiyad, Nadia ULg; Di Valentin, Emmanuel ULg et al

in BMC Molecular Biology (2007), 8

Varicella Zoster Virus Immediate Early 63 protein (IE63) has been shown to be essential for VZV replication, and critical for latency establishment. The activity of the protein as a transcriptional ... [more ▼]

Varicella Zoster Virus Immediate Early 63 protein (IE63) has been shown to be essential for VZV replication, and critical for latency establishment. The activity of the protein as a transcriptional regulator is not fully clear yet. Using transient transfection assays, IE63 has been shown to repress viral and cellular promoters containing typical TATA boxes by interacting with general transcription factors. In this paper, IE63 regulation properties on endogenous gene expression were evaluated using an oligonucleotide-based micro-array approach. We found that IE63 modulates the transcription of only a few genes in HeLa cells including genes implicated in transcription or immunity. Furthermore, we showed that this effect is mediated by a modification of RNA POL II binding on the promoters tested and that IE63 phosphorylation was essential for these effects. In MeWo cells, the number of genes whose transcription was modified by IE63 was somewhat higher, including genes implicated in signal transduction, transcription, immunity, and heat-shock signalling. While IE63 did not modify the basal expression of several NF-κB dependent genes such as IL-8, ICAM-1, and IκBα, it modulates transcription of these genes upon TNFα induction. This effect was obviously correlated with the amount of p65 binding to the promoter of these genes and with histone H3 acetylation and HDAC-3 removal. Conclusion While IE63 only affected transcription of a small number of cellular genes, it interfered with the TNF-inducibility of several NF-κB dependent genes by the accelerated resynthesis of the inhibitor IκBα. [less ▲]

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See detailCalcul de la marge et du prix
Van Caillie, Didier ULg

Learning material (2007)

This seminar presents the key elements allowing to estimate judiciously the main costs induced by a new activity and to establish a price that is both reflecting the internal cost structure and the ... [more ▼]

This seminar presents the key elements allowing to estimate judiciously the main costs induced by a new activity and to establish a price that is both reflecting the internal cost structure and the potential of the market. This seminar is adapted to activities taking place in the art industry. [less ▲]

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See detailcarnet de pédiatrie:orthopédie et traumatologie de l'enfant
Battisti, Oreste ULg

Learning material (2007)

notes de traumatologie et d'orthopédie sous forme de précis, clinique et imagerie.

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See detailStress oxydant : comment évaluer le statut du patient?
Pincemail, Joël ULg; Haleng, Jeanine ULg; Le Goff, Caroline ULg et al

in Nutrition Infos (2007), (oct/nov/déc), 47-50

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See detailA Data Mining Analysis Applied to a Straightening Process Database
Caprace, Jean-David ULg; Losseau, Nicolas; Bair, Frédéric ULg et al

in Ship Technology Research = Schiffstechnik (2007), 54(4), 177-183

The complexity of modern manufacturing processes in a highly competitive environment forces the manufacturers to invest massively in automation and monitoring systems. The large data flows from these new ... [more ▼]

The complexity of modern manufacturing processes in a highly competitive environment forces the manufacturers to invest massively in automation and monitoring systems. The large data flows from these new installations are sources of valuable and hidden knowledge that is so far hardly used. Data mining methods through integrated data analysis tools give a solution to this situation, allowing easy retrieval of knowledge starting from a data base. This is also a unique opportunity to learn faster about the process and to detect hidden and complex relationships between parameters involved. Within this framework we have decided to apply this data analysis method to the straightening process in shipbuilding. We refer to Caprace et al. (2007) for additional illustrations. In shipbuilding, the assembly of elements by welding involves temperature gradients within the ma- terial. These cause deformations which sometimes have to be reduced to obtain an acceptable surface flatness. The straightening process to eliminate these distortions for esthetical or functional reasons is labour intensive. Estimating the straightening impact on the production workload is interesting in the context of production simulation, cost assessment of ship hull, structure optimization, design for production, etc. To reach these objectives, the idea was to elaborate, through a data mining approach, a formula linking the straightening cost to the sections scantlings (plate thickness, dimension and inter-distance of longitudinal stiffeners, dimension and inter-distance of transversal frames) and to other section characteristics. This paper describes each stage of the methodology: data description, analysis of data quality, data exploration and finally choice of discriminatory attributes and the generation of the data-driven models. [less ▲]

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See detailEtude chromatographique de substances volatiles : cas des sémiochimiques
Heuskin, Stéphanie ULg

Scientific conference (2007, October)

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See detailPolymer (PE) synthesis - scaling up to industrial scale
Detrembleur, Christophe ULg

Conference (2007, September 30)

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See detailLes répercussions chez l’enfant du trouble psychique du parent : de la vie fœtale à plus tard.
Battisti, Oreste ULg; Marguglio, A; Caron, A

Conference (2007, September 29)

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See detailPancreas graft drainage in recipient duodenum: Preliminary experience
De Roover, Arnaud ULg; Coimbra Marques, Carla ULg; Detry, Olivier ULg et al

in Transplantation (2007), 84(6), 795-797

Pancreas graft survival has continuously improved over the years to become a main treatment option of uncontrolled complicated diabetes. Rejection remains the major challenge as it often goes unnoticed ... [more ▼]

Pancreas graft survival has continuously improved over the years to become a main treatment option of uncontrolled complicated diabetes. Rejection remains the major challenge as it often goes unnoticed until severe damage of the graft manifests itself by elevated blood sugar. Pancreas enzymes monitoring in the blood and in the urine is a sensitive marker of rejection but lack of specificity. Biopsy remains the gold standard. Cystoscopy-guided biopsy of bladder-drained pancreas has a good success rate for obtaining tissue but the vesical drainage exposes to metabolic and urologic morbidity. Percutaneous pancreas biopsy can be performed with a low morbidity rate but severe complications can occur. We discuss a technique of pancreas transplantation with the drainage of exocrine secretions of the pancreatic graft in the recipient duodenum, which permits easy monitoring of the graft by upper endoscopy of the duodenum. [less ▲]

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See detailAmphibia-Reptilia: Editorial report 2005-2007
Denoël, Mathieu ULg

Conference (2007, September 22)

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See detailRelation between the poultry production systems and the Highly Pathogenic Avian Influenza (HPAI) in Vietnam
Phan Dang, Thang ULg; Marisa Peyre; Stéphanie Desvaux et al

in 13th International Conference of the Asian – Australasian Association of Animal Production Societies (AAAP) (2007, September 22)

In 2003, the poultry population was about 254.6 millions heads. The poultry herd is mainly concentrated in the Red River Delta (RRD) and in the Mekong Delta with about 50% of poultry population. The ... [more ▼]

In 2003, the poultry population was about 254.6 millions heads. The poultry herd is mainly concentrated in the Red River Delta (RRD) and in the Mekong Delta with about 50% of poultry population. The Highly Pathogenic Avian Influenza caused by H5N1 virus was removed in almost of provinces in Vietnam from 2004 until now but millions of birds were culled to reach this situation and it had large economical and sociological impacts. A question emerge: how can we limit this epidemic? A research on the relation between poultry production systems and the HPAI had been carried out in two provinces: Ha Tay (RRD) and Long An (Mekong Delta) from March to August 2007. The results showed that there are three principal poultry production systems which are commercial poultry production systems with good breeding facilities (system 1); commercial poultry production systems without good breeding facilities (system 2), and small scale poultry production system (system 3). The number of birds reared in the commercial systems was more important than that of the small system, conversely the number of species rising in the system 2 and 3 was more important than in the system 1. The proportion of households having poultry herd with HPAI in the period of 2003-2005 in the system 2 and 3 were more important than that of the system 1 (21-59% compare with 33-36%). The study had showed that all poultry belonging to the system 1 were vaccinated; when the proportion of vaccinated animals were about 87-90% for the system 2, and 58% for the system 3. [less ▲]

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See detailResidential Lease in Belgium
Kohl, Benoît ULg

Conference given outside the academic context (2007)

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See detailChecking the internal pedagogical consistency of a game learning situation: the Leclercq’s triple consistency triangle
Castaigne, J.-L.; Petit, L; Verpoorten, Dominique ULg

in Targamadze, A (Ed.) Proceedings of the Advanced Learning Technologies and Applications (ALTA) conference (2007, September 20)

Leclercq’s triangle is a conceptual tool used for securing the pedagogical validity of learning situations. It materializes the sound pedagogy principle which commands to establish a triple consistency ... [more ▼]

Leclercq’s triangle is a conceptual tool used for securing the pedagogical validity of learning situations. It materializes the sound pedagogy principle which commands to establish a triple consistency between objectives, methods and evaluation in any given learning situation. The ELEKTRA adventure game provides a practical illustration of its relevance. [less ▲]

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See detailIntroducing teachers and instructional developers to learning objects Four suggested shifts in prevailing discourse
Verpoorten, Dominique ULg

in Targamadze, A (Ed.) Proceedings of the Advanced Learning Technologies and Applications conference (ALTA’2007) (2007, September 20)

Being convinced that the learning objects yields value creation promises for e-learning, the author, drawing on state-of-the art literature, his experience of two European projects dealing with learning ... [more ▼]

Being convinced that the learning objects yields value creation promises for e-learning, the author, drawing on state-of-the art literature, his experience of two European projects dealing with learning objects and his experience as a teacher, documents 4 issues regarding teachers' awareness and acceptance of this emergent instructional design approach. [less ▲]

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See detailLaudatio Alberto Manguel
Durand, Pascal ULg

Speech/Talk (2007)

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See detailDevenir mobile de corps et d’esprit
Rentier, Bernard ULg

Speech/Talk (2007)

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See detailPlace(s) et rôle(s) de l’éducateur physique dans la société contemporaine
Cloes, Marc ULg

Conference given outside the academic context (2007)

Si, au fil du 20ème siècle, le sport est devenu un véritable phénomène social et économique, l’activité physique semble prendre une place croissante dans les préoccupations actuelles. Les deux concepts ... [more ▼]

Si, au fil du 20ème siècle, le sport est devenu un véritable phénomène social et économique, l’activité physique semble prendre une place croissante dans les préoccupations actuelles. Les deux concepts sont parfois utilisés sans discernement. Nous considérons toutefois qu’ils se réfèrent à des significations différentes. Dès lors, il s’avère important de les distinguer afin de mieux percevoir les modalités de pratique auxquels ils sont associés et de comprendre les nuances pouvant exister au niveau des acteurs chargés de leur organisation. Le sport est défini comme étant «toutes formes d’activités physiques qui, à travers une participation organisée ou non, ont pour objectif l’expression ou l’amélioration de la condition physique et psychique, le développement des relations sociales ou l’obtention de résultats en compétition de tous niveaux » (Conseil de l’Europe, 1992). De son côté, l’activité physique « comprend tout mouvement du corps produit par les muscles squelettiques et qui résulte en une augmentation substantielle par rapport à la dépense d’énergie de repos » (Bouchard & Shephard, 1993). Elle peut être sportive, associée au travail, aux tâches domestiques, aux déplacements ou encore aux loisirs (Sallis, Cervero, Ascher, Henderson, Kraft & Kerr, 2006). Il apparaît clairement que le concept d’activité physique englobe le sport, ce dernier n’étant qu’une forme d’activité physique. Ceci présente des implications particulièrement importantes lorsqu’il s’agit d’étudier la place et le rôle des personnes qui agissent sur le terrain et que l’on associe de plus en plus à l’effort réalisé actuellement pour lutter contre la sédentarité croissante de la population mondiale, dans la perspective de maintenir un état de santé socialement acceptable. Le terme « éducateur physique » est une expression tirée du vocabulaire québécois. [less ▲]

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