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See detailThe Acyclic Nucleoside Phosphonate Analogues, Adefovir, Tenofovir And Pmedap, Efficiently Eliminate Banana Streak Virus From Banana (Musa Spp.)
Helliot, B.; Panis, B.; Frison, E. et al

in Antiviral Research (2003), 59(2), 121-126

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See detailUltrastructural Changes Associated With Cryopreservation Of Banana (Musa Spp.) Highly Proliferating Meristems
Helliot, B.; Swennen, R.; Poumay, Y. et al

in Plant Cell Reports (2003), 21(7), 690-698

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See detailLésions dentaires cervicales non carieuses - Deuxième partie
Gueders, Audrey ULg

in Actualités Dentaires de l'Université de Liège (2003)

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See detailDetails on DARWIN and the Search for Extrasolar Planets
Kaltenegger, L.; Fridlund, M.; Absil, Olivier ULg

in Deming, Drake; Seager, Sara (Eds.) Scientific Frontiers in Research on Extrasolar Planets (2003)

The direct detection of an earth-like planet close to its parent star is challenging because the signal detected from the parent star is between 10[SUB]9[/SUB] and 10[SUB]6[/SUB] times brighter than the ... [more ▼]

The direct detection of an earth-like planet close to its parent star is challenging because the signal detected from the parent star is between 10[SUB]9[/SUB] and 10[SUB]6[/SUB] times brighter than the signal of a planet in the visual and infrared (IR), respectively. Future space based missions like DARWIN and TPF concentrate on the region between 6 and 18 microns, a region that contains the carbon dioxide, water, and ozone spectral features of the atmosphere. Using several small collecting telescopes and a beam combiner allows us to build an instrument with an angular resolution normally associated with monolithic telescopes of much larger diameters. The relative positions of the telescopes, forming the interferometer, are selected such that when the optical signals, collected by the individual telescopes, are coherently combined, the small angular distance between the planet and the star can be resolved. Different configurations of the free flying interferometer array influence the performance of the nulling array. The concepts for space nulling interferometers and the influence of different schemes of beam combination on the detected signal are investigated. The contribution of background noise to the detected signal is examined. [less ▲]

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See detailThe Darwin-GENIE Experiment: An ESA-ESO Partnership
Gondoin, Ph; Absil, Olivier ULg; Erd, C. et al

in Sembach, K. R.; Blades, J. C.; Illingworth, G. D. (Eds.) et al Hubble's Science Legacy: Future Optical/Ultraviolet Astronomy from Space (2003)

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See detailGENIE: a ground-based precursor for the IRSI-Darwin mission
Absil, Olivier ULg

in Aime, Claude; Soummer, Rémi (Eds.) Astronomy with High Contrast Imaging (2003)

During the preliminary phase A of the Ground-based European Nulling Interferometer Experiment (GENIE), a number of interferometric configurations have been studied, in the cases of exozodiacal cloud and ... [more ▼]

During the preliminary phase A of the Ground-based European Nulling Interferometer Experiment (GENIE), a number of interferometric configurations have been studied, in the cases of exozodiacal cloud and hot Jupiter detection. Their expected performances have been computed in light of the measured or expected performances of the VLTI sub-systems. A simple Bracewell nulling interferometer, formed of two Unit Telescopes and working in the L' or N bands, has been identified as a good candidate configuration for exozodiacal cloud detection. External or internal chopping, fringe tracking and intensity matching will be critical issues for this configuration. In the case of hot Jupiter detection, a double Bracewell with internal modulation in the L' band seems well appropriate, and should allow to carry out low resolution spectroscopy on a few bright exoplanets. The basic assumptions and computations which have lead to these candidate configurations are described in this paper. [less ▲]

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See detailCandidate VLTI Configurations for the GENIE Nulling Experiment
Absil, Olivier ULg; Gondoin, P.; Erd, C. et al

in Deming, Drake; Seager, Sara (Eds.) Scientific Frontiers in Research on Extrasolar Planets (2003)

The European Space Agency (ESA) and the European Southern Observatory (ESO) initiate a definition study for a Ground-based European Nulling Interferometer Experiment (Darwin-GENIE). The experiment will ... [more ▼]

The European Space Agency (ESA) and the European Southern Observatory (ESO) initiate a definition study for a Ground-based European Nulling Interferometer Experiment (Darwin-GENIE). The experiment will use the Very Large Telescope Interferometer (VLTI) operating on Mount Paranal (Chile). The objective of GENIE is to gain experience in the manufacture and operation of a nulling interferometer using a design concept and technology representative of the ESA IRSI-Darwin space mission. GENIE will prepare the IRSI-Darwin science program through a systematic search for exozodiacal dust clouds around IRSI-Darwin candidate targets. GENIE also aims to perform IRSI-Darwin related science achievable from ground including the detection of low-mass companions (if possible, hot jupiters) around nearby stars. Among the variety of telescope sizes and positions on the VLTI site, candidate interferometric configurations have been identified for GENIE, taking into account the limitation imposed by the Earth's atmosphere. They include a Bracewell interferometer for exozodiacal clouds detection in the N band and a double Bracewell configuration with internal modulation for extrasolar jupiter detection in the L' band. The present paper presents the prospective performance of these configurations in light of current specifications of major VLTI subsystems. [less ▲]

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See detailUsing artificial neural networks to estimate rotor angles and speeds from phasor measurements
Del Angel, Alberto; Glavic, Mevludin; Wehenkel, Louis ULg

(2003)

This paper deals with an improved use of phasor measurements. In particular, the paper focuses on the development of a technique for estimation of generator rotor angle and speed, based on phasor ... [more ▼]

This paper deals with an improved use of phasor measurements. In particular, the paper focuses on the development of a technique for estimation of generator rotor angle and speed, based on phasor measurement units, for transient stability assessment and control in real-time. Two multilayered feed-forward artificial neural networks are used for this purpose. One for the estimation of rotor angle and another for the estimation of rotor speed. The validation has been made by simulation in a power system because techniques for the direct measurement were not available. Results obtained with the help of a simple one machine to infinite bus system are presented and compared against those obtained using analytical formulas derived from the generator classical model. [less ▲]

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See detailNumerus clausus en fin de troisieme candidature en medecine: mort annoncee d'une heresie?
Rabenda, Véronique ULg; Boniver, Jacques ULg; Reginster, Jean-Yves ULg

in Revue Médicale de Liège (2003), 58(7-8, Jul-Aug), 508-14

Owing to the establishment of a procedure aiming at a reduction of the medical supply (numerus clausus), the French Community of Belgium had decided to introduce, at the end of the third year of medical ... [more ▼]

Owing to the establishment of a procedure aiming at a reduction of the medical supply (numerus clausus), the French Community of Belgium had decided to introduce, at the end of the third year of medical studies (third candidature), a procedure of selective attribution of the certificate allowing for a unlimited medical practice. We assessed the predictive value of the results obtained during and at the end of the first candidature (first year of medicine) for the attribution of this certificate. We studied the results of the 225 students enrolled in the first candidature in medicine at the University of Liege during the academic year 1997-1998, and we correlated them to the subsequent attribution (1999-2000- and 2000-2001) of the certificate. The success of the first candidature in the first or second session is an important predicting factor towards the reception of the certificate. A non-authorization to continue the studies in medicine in case of failure in the first session or a non-authorization to repeat the first candidature in case of failure in the second session would have, respectively, a negative predictive value (NPV) of 91.9% and 97.4% and would allow to restream 111 students at the end of the first session or 39 students at the end of the first candidature. The results of the preliminary assessments mode during the month of January are also highly predictive of the chances to get the certificate. Among the 160 students who have not successfully passed a minimum of 3 exams, only 14 students obtained the certificate. The restreaming of those students would correspond to a NPV of 91.2%. Students who were not successful in a minimum of 2 exams would have less than 5% chance to obtain the certificate. In this case, 109 students would be restreamed (NPV = 95.4%). In conclusion, the selection of the students who will obtain, at the end of the third year of medicine, the certificate allowing them for an unlimited medical practice is obtained, in a large proportion, during the first candidature and especially after the session of January. In view of those results and considering the decree abolishing the selection at the end of the third year of medical studies, one could argue about the appropriateness of the current procedure, chosen by the French Community of Belgium, compared to other solutions prioritising an earlier selection of the future doctors. [less ▲]

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See detailOvero lethal white syndrome - two case reports and a review of the litterature
Sandersen, Charlotte ULg; Delguste, Catherine ULg; Cassart, Dominique ULg et al

in Annales de Médecine Vétérinaire (2003), 147(5, OCT-NOV), 359-364

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See detailEphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway.
Deroanne, Christophe ULg; Vouret-Craviari, Valerie; Wang, Bingcheng et al

in Journal of Cell Science (2003), 116(Pt 7), 1367-76

Interactions between the Eph receptor tyrosine kinase and ephrin ligands transduce short-range signals regulating axon pathfinding, development of the cardiovascular system, as well as migration and ... [more ▼]

Interactions between the Eph receptor tyrosine kinase and ephrin ligands transduce short-range signals regulating axon pathfinding, development of the cardiovascular system, as well as migration and spreading of neuronal and non-neuronal cells. Some of these effects are believed to be mediated by alterations in actin dynamics. The members of the small Rho GTPase family elicit various effects on actin structures and are probably involved in Eph receptor-induced actin modulation. EphrinA1 is proposed to contribute to angiogenesis as it is strongly expressed at sites of neovascularization. Moreover, angiogenic factors induce the expression of ephrinA1 in endothelial cells. In this study, using rat vascular smooth muscle cells (VSMCs), we investigated the contribution of the small Rho GTPases in ephrinA1-induced integrin inactivation. EphrinA1 did not significantly affect early adhesion of VSMCs on purified laminin or fibronectin, but strongly impaired cell spreading. The Rho kinase inhibitor Y-27632 partly reversed the ephrinA1 effect, suggesting involvement of Rho in this model. However, inhibition of RhoA synthesis with short interfering (si)RNA had a modest effect, suggesting that RhoA plays a limited role in ephrinA1-mediated inhibition of spreading in VSMCs. The ephrinA1-mediated morphological alterations correlated with inhibition of Rac1 and p21-activated kinase 1 (PAK1) activity, and were antagonized by the expression of a constitutively active Rac mutant. Moreover, repression of Rac1 synthesis with siRNA amplifies the ephrinA1-induced inhibition of spreading. Finally, sphingosine-1-phosphate (S1P), a lipid mediator known to inhibit Rac activation in VSMCs amplifies the ephrinA1 effect. In conclusion, our results emphasize the role of the Rac/PAK pathway in ephrinA1-mediated inhibition of spreading. In this way, ephrinA1, alone or in synergy with S1P, can participate in blood vessel destabilization, a prerequisite for angiogenesis. [less ▲]

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See detailRetreatment of hepatitis C non-responsive to interferon. A placebo controlled randomized trial of ribavirin monotherapy versus combination therapy with Ribavirin and Interferon in 121 patients in the Benelux [ISRCTN53821378]
Veldt, Bart J; Brouwer, Johannes T; Adler, Michael et al

in BMC Gastroenterology (2003), 3(1), 24

BACKGROUND: Evidence based medicine depends on unbiased selection of completed randomized controlled trials. For completeness it is important to publish all trials. This report describes the first large ... [more ▼]

BACKGROUND: Evidence based medicine depends on unbiased selection of completed randomized controlled trials. For completeness it is important to publish all trials. This report describes the first large randomised controlled trial where combination therapy was compared to placebo therapy and to ribavirin monotherapy, which has not been published until now. METHODS: One hundred and twenty one patients with chronic hepatitis C and elevated transaminases who did not respond to previous treatment with standard interferon monotherapy, were included from 16 centers in Belgium, the Netherlands and Luxembourg between 1992 and 1996. Patient poor-response characteristics were: genotype 1 (69%), HCV RNA above 2 x 10(6) copies/ml (55%) and cirrhosis (38%). Patients were randomized to 6 months combination therapy with interferon alpha-2b (3 MU tiw) and ribavirin (1000-1200 mg/day), 6 months ribavirin monotherapy (1000-1200 mg/day) or 6 months ribavirin placebo. The study was double blinded for the ribavirin/placebo component. One patient did not fit the entry criteria, and 3 did not start. All 117 patients who received at least one dose of treatment were included in the intention to treat analysis. RESULTS: At the end of treatment, HCV RNA was undetectable in 35% of patients on combination therapy and in none of the patients treated with ribavirin monotherapy or placebo. The sustained virological response rate at 6 months after therapy was 15% for patients treated with interferon and ribavirin.During the 6 months treatment period 13% of patients on interferon ribavirin combination therapy, 13% of patients on ribavirin monotherapy and 11% of patients on placebo withdrew due to side effects or noncompliance. At 24 weeks of treatment the mean Hb level was 85% of the baseline value, which means a mean decrease from 9.1 mmol/l to 7.8 mmol/l. The Hb levels at the end of treatment were not significantly different from patients treated with ribavirin monotherapy (p = 0.76). End of treatment WBC was significantly lower in patients treated with combination therapy, compared to ribavirin (p < 0.01) as well as for patients treated with ribavirin monotherapy compared to placebo (p < 0.01). DISCUSSION: This belated report on the only placebo controlled study of interferon ribavirin combination therapy in non responders to standard doses of interferon monotherapy documents the effectiveness, be it limited, of this approach as well as the dynamics of the effects on blood counts. [less ▲]

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See detailFormation continue en jonglerie
Fischbach, Willi; Cloes, Marc ULg

in Revue de l'Education Physique (2003), 43(4), 114-125

Le premier auteur est étudiant passionné de jonglerie, il a réalisé un mémoire de fin d’études portant sur l’utilisation de la jonglerie en milieu scolaire. Cet article est préparé à partir du contenu de ... [more ▼]

Le premier auteur est étudiant passionné de jonglerie, il a réalisé un mémoire de fin d’études portant sur l’utilisation de la jonglerie en milieu scolaire. Cet article est préparé à partir du contenu de formations continuées proposées aux maîtres de stage qui collaborent à la formation des étudiants de l’AESS de l’Institut Supérieur d’Education Physique et de Kinésithérapie de l’ULg. [less ▲]

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See detailIncreased dioxin/PCB body burden in diabetics: findings in a population-based study in Belgium
Fierens, S.; Mairesse, H.; Heilier, H. et al

in Organohalogen Compounds (2003), 60-65

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See detailLevels of selected PBDEs and PCBs in Belgian human milk
Pirard, C.; De Pauw, Edwin ULg; Focant, Jean-François ULg

in Organohalogen Compounds (2003), 61

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See detailFast, sensitive, and comprehensive analytical methods including three-dimensional analysis (GCXGC-TOFMS) for measuring halogenated persistent organic pollutants
Patterson, Donald G.; Turner, Wayman E.; Sjödin, Andreas et al

in Organohalogen Compounds (2003), 60-65

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See detailMeasurable impact of an old MSWI on the level of dioxins in free-range chickens and eggs grown in its vicinity
Pirard, C.; Focant, Jean-François ULg; Massart, A. C. et al

in Organohalogen Compounds (2003), 60-65

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See detailSemi-automated high throughput extraction and cleanup method for the analysis of polybrominated diphenyl ethers, polybrominated, and polychlorinated biphenyls in human serum
SjÖdin, Andreas; Jones, Richard S.; Lapeza, Chester et al

in Organohalogen Compounds (2003), 60

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