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See detailHigh doses of transplanted CD34(+) cells are associated with rapid T-cell engraftment and lessened risk of graft rejection, but not more graft-versus-host disease after nonmyeloablative conditioning and unrelated hematopoietic cell transplantation
Baron, Frédéric ULg; Maris, M. B.; Storer, B. E. et al

in Leukemia (2005), 19(5), 822-828

This report examines the impact of graft composition on outcomes in 130 patients with hematological malignancies given unrelated donor granulocyte-colony-stimulating-factor-mobilized peripheral blood ... [more ▼]

This report examines the impact of graft composition on outcomes in 130 patients with hematological malignancies given unrelated donor granulocyte-colony-stimulating-factor-mobilized peripheral blood mononuclear cells (G-PBMC) ( n = 116) or marrow ( n = 14) transplantation after nonmyeloablative conditioning with 90 mg/m(2) fludarabine and 2Gy TBI. The median number of CD34(+) cells transplanted was 6.5 x 10(6)/ kg. Higher numbers of grafted CD14(+) ( P = 0.0008), CD3(+) ( P = 0.0007), CD4(+) ( P = 0.001), CD8(+) ( P = 0.004), CD3 - CD56(+) ( P = 0.003), and CD34(+) ( P = 0.0001) cells were associated with higher levels of day 28 donor T-cell chimerism. Higher numbers of CD14(+) ( P = 0.01) and CD34(+) ( P = 0.0003) cells were associated with rapid achievement of complete donor T-cell chimerism, while high numbers of CD8(+) ( P = 0.005) and CD34(+) ( P = 0.01) cells were associated with low probabilities of graft rejection. When analyses were restricted to G-PBMC recipients, higher numbers of grafted CD34(+) cells were associated with higher levels of day 28 donor T-cell chimerism ( P = 0.01), rapid achievement of complete donor T-cell chimerism ( P = 0.02), and a trend for lower risk for graft rejection ( P = 0.14). There were no associations between any cell subsets and acute or chronic GVHD nor relapse/progression. These data suggest more rapid engraftment of donor T cells and reduced rejection rates could be achieved by increasing the doses of CD34(+) cells in unrelated grafts administered after nonmyeloablative conditioning. [less ▲]

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See detailA CIDR Prefix Stopping Rule for Topology Discovery
Donnet, Benoît ULg; Friedman, Timur

in Proc. Algotel (2005, May)

Recently, a first step towards a highly distributed IP-level topology discovery tool has been made with the introduction of the Doubletree algorithm. Doubletree is an efficient cooperative algorithm that ... [more ▼]

Recently, a first step towards a highly distributed IP-level topology discovery tool has been made with the introduction of the Doubletree algorithm. Doubletree is an efficient cooperative algorithm that allows the discovery of a large portion of nodes and links in the network while strongly reducing probing redundancy on nodes and destinations as well as the amount of probes sent. In this paper, we propose to reduce more strongly the load on destinations and, more essentially, the communication cost required for the cooperation by introducing a probing stop rule based on CIDR address prefixes. [less ▲]

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See detailIn vitro characterization of the Bacillus subtilis protein tyrosine phosphatase YwqE
Mijakovic, Ivan; Musumeci, Lucia ULg; Tautz, Lutz et al

in Journal of Bacteriology (2005), 187(10), 3384-90

Both gram-negative and gram-positive bacteria possess protein tyrosine phosphatases (PTPs) with a catalytic Cys residue. In addition, many gram-positive bacteria have acquired a new family of PTPs, whose ... [more ▼]

Both gram-negative and gram-positive bacteria possess protein tyrosine phosphatases (PTPs) with a catalytic Cys residue. In addition, many gram-positive bacteria have acquired a new family of PTPs, whose first characterized member was CpsB from Streptococcus pneumoniae. Bacillus subtilis contains one such CpsB-like PTP, YwqE, in addition to two class II Cys-based PTPs, YwlE and YfkJ. The substrates for both YwlE and YfkJ are presently unknown, while YwqE was shown to dephosphorylate two phosphotyrosine-containing proteins implicated in UDP-glucuronate biosynthesis, YwqD and YwqF. In this study, we characterize YwqE, compare the activities of the three B. subtilis PTPs (YwqE, YwlE, and YfkJ), and demonstrate that the two B. subtilis class II PTPs do not dephosphorylate the physiological substrates of YwqE. [less ▲]

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See detailNaming very familiar people : when retrieving names is faster than retrieving semantic biographical information
Brédart, Serge ULg; Brennen, T.; Delchambre, Marie ULg et al

in British Journal of Psychology (2005), 96(Pt 2), 205-214

One of the most reliable findings in the literature on person indentification is that semantic categorization of a face occurs more quickly than naming a face. Here we present two experiments in which ... [more ▼]

One of the most reliable findings in the literature on person indentification is that semantic categorization of a face occurs more quickly than naming a face. Here we present two experiments in which participants are shown the faces of their colleagues, i.e., personally familiar people, encountered with high frequency. In each experiment, naming was faster than making a semantic classification, despite the fact that the semantic classifications were highly salient to the participants (Experiment I highest degree obtained; Experiment 2: nationality). The finding is consistent with models that allow or parallel access from faces to semantic information and to names, and demonstrates the need for the frequency of exposure to names to be taken into account in models of proper name processing e.g. Burke, Mackay, Worthley and Wade (1991). [less ▲]

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See detailA framework for the complexity of high-multiplicity scheduling problems
Brauner, Nadia; Crama, Yves ULg; Grigoriev, Alexander et al

in Journal of Combinatorial Optimization (2005), 9(3), 313-323

The purpose of this note is to propose a complexity framework for the analysis of high multiplicity scheduling problems. Part of this framework relies on earlier work aiming at the definition of output ... [more ▼]

The purpose of this note is to propose a complexity framework for the analysis of high multiplicity scheduling problems. Part of this framework relies on earlier work aiming at the definition of output-sensitive complexity measures for the analysis of algorithms which produce "large" outputs. However, different classes emerge according as we look at schedules as sets of starting times, or as related single-valued mappings. [less ▲]

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See detailLa polygamie devant la Cour d'arbitrage
Carlier, Jean-Yves ULg

in Journal du Juriste (2005), 42(1), 1

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See detailA naturalistic study of the determinants of health related quality of life improvement in osteoarthritic patients treated with non-specific non-steroidal antiinflammatory drugs
Rabenda, Véronique ULg; Burlet, N.; Ethgen, Olivier ULg et al

in Annals of the Rheumatic Diseases (2005), 64(5), 688-693

OBJECTIVES: To capture changes in the quality of life (QoL) occurring in patients with osteoarthritis (OA) during treatment with non-specific non-steroidal anti-inflammatory drugs (NSAIDs) and to identify ... [more ▼]

OBJECTIVES: To capture changes in the quality of life (QoL) occurring in patients with osteoarthritis (OA) during treatment with non-specific non-steroidal anti-inflammatory drugs (NSAIDs) and to identify factors that predict such changes. METHODS: A naturalistic, prospective follow up of 783 patients with OA in whom primary care physicians decided to start treatment with non-selective NSAIDs. Short Form-36 (SF-36) and the Western Ontario and McMaster Universities OA index (WOMAC) were assessed at baseline and after 3 months. Baseline results were compared with QoL values in 4800 subjects randomly selected from the general population. Multiple regression analysis was performed to identify determinants of QoL at baseline and measures influencing changes in SF-36 or WOMAC during follow up. RESULTS: All QoL dimensions were significantly (p<0.01) decreased in patients with OA compared with controls. Significant improvement (p<0.05) in four dimensions of the SF-36 (vitality, role emotional, role physical, bodily pain) and in all components of the WOMAC was seen between baseline and month 3. Older age, female sex, longer duration of OA, and a higher number of comorbidities were the major determinants of a poor QoL at baseline. Maximal benefit from non-specific NSAIDs was seen in patients with the most severe impairment in QoL and the shortest duration of OA. CONCLUSION: OA negatively impacts all dimensions of the QoL. Non-specific NSAIDs improve the QoL in patients with OA treated in a "real life setting". The profile of patients receiving maximal benefit from such treatment may be of interest for health providers, enabling them to decide who should preferentially be given cytoprotective treatments or coxibs. [less ▲]

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See detailRechnergestützte Baukostenschätzung im Schiffsentwurf
Bertram, Volker; Maisonneuve, Jean-Jacques; Caprace, Jean-David ULg et al

in Ship und Hafen (2005), 5

Various approaches for better initial cost estimates for ships are reviewed, compiling recent activities in the USA, Europe and Japan. The trends is towards bottom-up approaches, capable reflecting local ... [more ▼]

Various approaches for better initial cost estimates for ships are reviewed, compiling recent activities in the USA, Europe and Japan. The trends is towards bottom-up approaches, capable reflecting local design changes, and simulation based-methods. Coupled to structural computer-aided design programs, these cost estimates modules then allow higher precision for cost estimates even for unconventional ships during early design. [less ▲]

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See detailModelling, Simulation and Optimization of a Shipbuilding Workshop
Bair, Frédéric ULg; Langer, Yves; Caprace, Jean-David ULg et al

in COMPIT'2005 -Conference on Computer Applications and Information Technology in the Maritime Industries, Hamburg (2005, May)

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See detailOptimization of Surface Allocation using Heuristic Approaches
Langer, Yves; Bay, Maud ULg; Crama, Yves ULg et al

in COMPIT 2005 , Hambourg, Germany (2005, May)

In this paper, we present a scheduling problem that arises in factories producing large building blocks (in our case, a shipyard workshop producing prefabricated keel elements). The factory is divided in ... [more ▼]

In this paper, we present a scheduling problem that arises in factories producing large building blocks (in our case, a shipyard workshop producing prefabricated keel elements). The factory is divided in several equal size areas. The blocks produced in the factory are very large, and, once a building block is placed in the factory, it cannot be moved until all processes on the building block are finished. The blocks cannot overlap. The objective is to maximize the number of building blocks produced in the factory during a certain time window. To solve this problem, we propose heuristics inspired by techniques initially developed for the three-dimensional bin packing problem, e.g. Faroe and al. (2003), since constraints for both problems are quite similar. Starting from an unfeasible solution, where blocks can overlap, a Guided Local Search (GLS) heuristic is used to minimize the sum of total overlap. If a solution with zero overlap is found, then it is a feasible solution; otherwise the block with the biggest overlap is removed and the procedure is restarted. The GLS algorithm has been improved by Fast Local Search (FST) tech- niques in order to speed up convergence to a local minimum. Additionally, neighborhoods are restricted to their smallest size so as to allow their evaluation in polynomial-time. In a last step, we explain the additional real-life issues arising in the industrial application and how firm-specific constraints can be conveniently considered by the model. [less ▲]

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See detailEditorial : le français? La base de tous les apprentissages
Defays, Jean-Marc ULg; Lefebvre, Jacques; Abraham, Hélène et al

in Français 2000 (2005), (196-197), 2-5

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See detailStrontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study
Reginster, Jean-Yves ULg; Seeman, E.; De Vernejoul, M. C. et al

in Journal of Clinical Endocrinology and Metabolism (2005), 90(5), 2816-2822

Background: Strontium ranelate, a new oral drug shown to reduce vertebral fracture risk in postmenopausal women with osteoporosis, was studied in the Treatment of Peripheral Osteoporosis (TROPOS) study to ... [more ▼]

Background: Strontium ranelate, a new oral drug shown to reduce vertebral fracture risk in postmenopausal women with osteoporosis, was studied in the Treatment of Peripheral Osteoporosis (TROPOS) study to assess its efficacy and safety in preventing nonvertebral fractures also. Methods: Strontium ranelate (2 g/d) or placebo were randomly allocated to 5091 postmenopausal women with osteoporosis in a double-blind placebo-controlled 5-yr study with a main statistical analysis over 3 yr of treatment. Findings: In the entire sample, relative risk (RR) was reduced by 16% for all nonvertebral fractures (P = 0.04), and by 19% for major fragility fractures (hip, wrist, pelvis and sacrum, ribs and sternum, clavicle, humerus) (P = 0.031) in strontium ranelate-treated patients in comparison with the placebo group. Among women at high risk of hip fracture ( age ≥ 74 yr and femoral neck bone mineral density T score ≤-3, corresponding to -2.4 according to NHANES reference) (n = 1977), the RR reduction for hip fracture was 36% (P = 0.046). RR of vertebral fractures was reduced by 39% (P < 0.001) in the 3640 patients with spinal x-rays and by 45% in the subgroup without prevalent vertebral fracture. Strontium ranelate increased bone mineral density throughout the study, reaching at 3 yr (P < 0.001): +8.2% (femoral neck) and +9.8% (total hip). Incidence of adverse events (AEs) was similar in both groups. Conclusion: This study shows that strontium ranelate significantly reduces the risk of all nonvertebral and in a high-risk subgroup, hip fractures over a 3-yr period, and is well tolerated. It confirms that strontium ranelate reduces vertebral fractures. Strontium ranelate offers a safe and effective means of reducing the risk of fracture associated with osteoporosis. [less ▲]

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See detailSpin-cluster effect and lattice-deformation-induced Kondo effect, spinglass freezing, and strong phonon scattering in La0.7Ca0.3Mn1-xCrxO3
Wu, Bai-Mei; Li, Bo; Zhen, Wei-Hua et al

in Journal of Applied Physics (2005), 97(10, Part 1), 103908

Besides the Kondo effect observed in dilute magnetic alloys, the Cr-doped perovskite manganate compounds La0.7Ca0.3Mn1-xCrxO3 also exhibit Kondo effect and spin-glass freezing in a certain composition ... [more ▼]

Besides the Kondo effect observed in dilute magnetic alloys, the Cr-doped perovskite manganate compounds La0.7Ca0.3Mn1-xCrxO3 also exhibit Kondo effect and spin-glass freezing in a certain composition range. An extensive investigation for the La0.7Ca0.3Mn1-xCrO3 (x=0.01, 0.05, 0.10, 0.3, 0.6, and 1.0) system on the magnetization and ac susceptibility, the resistivity and magnetoresistance, as well as the thermal conductivity is done at low temperature. The spin-glass behavior has been confirmed for these compounds with x=0.05, 0.1, and 0.3. For temperatures above T-f (the spin-glass freezing temperature) a Curie-Weiss law is obeyed. The paramagnetic Curie temperature 0 is dependent on Cr doping. Below T-f there exists a Kondo minimum in the resistivity. Colossal magnetoresistance has been observed in this system with Cr concentration up to x=0.6. We suppose that the substitution of Mn with Cr dilutes Mn ions and changes the long-range ferromagnetic order of La0.7Ca0.3MnO3. These behaviors demonstrate that short-range ferromagnetic correlation and fluctuation exist among Mn spins far above T-f. Furthermore, these interactions are a precursor of the cooperative freezing at T-f. The "double bumps" feature in the resistivity-temperature curve is observed in compounds with x= 0.05 and 0.1. The phonon scattering is enhanced at low temperatures, where the second peak of double bumps comes out. The results indicate that the spin-cluster effect and lattice deformation induce Kondo effect, spin-glass freezing, and strong phonon scattering in mixed perovskite La0.7Ca0.3Mn1-xCrO3. (c) 2005 American Institute of Physics. [less ▲]

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See detailStimulation of human trophoblast invasion by placental growth hormone
Lacroix, M. C.; Guibourdenche, J.; Fournier, T. et al

in Endocrinology (2005), 146(5), 2434-2444

A critical step in establishment of human pregnancy is the invasion of the uterus wall by the extravillous cytotrophoblast (EVCT), a process regulated by multiple autocrine and paracrine factors. Hormones ... [more ▼]

A critical step in establishment of human pregnancy is the invasion of the uterus wall by the extravillous cytotrophoblast (EVCT), a process regulated by multiple autocrine and paracrine factors. Hormones belonging to the GH/prolactin family are expressed at the maternofetal interface. Because they are involved in cell motility in various models, we examined the possible regulatory role of human placental GH (hPGH) in EVCT invasiveness. By using an in vitro invasion model, we found that EVCT isolated from first-trimester chorionic villi and cultured on Matrigel secreted hPGH and expressed human GH receptor ( hGHR). These data were confirmed by in situ immunohistochemistry. EVCT expressed the full-length and truncated forms of hGHR, and the Janus kinase-2/signal transducer and activator of transcription factor-5 signaling pathway was activated in EVCT by hPGH treatment. Strong hPGH and hGHR expression was observed when EVCT invaded Matrigel and moved through the pores of the filter on which they were cultured. hPGH stimulated EVCT invasiveness, and this effect was inhibited by a Janus kinase-2 inhibitor. Interestingly, hPGH was more efficient than pituitary GH in stimulating EVCT invasiveness. These results offer the first evidence for a placental role of hPGH and suggest an autocrine/ paracrine role of hPGH in the regulation of trophoblast invasion. [less ▲]

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See detailUniversité : l'éducation ou la croissance
Bachelet, Jean-François ULg

in Vivant : l'actualité des sciences et débats sur le vivant (2005)

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See detailGeneralized Shape optimization based on the Level Set method
Van Miegroet, Laurent ULg; Moës, Nicolas; Fleury, Claude ULg et al

in Herskowitz, José (Ed.) Proceedings of the 6th World Congress of Structural and Multidisciplinary Optimization (WCSMO6) (2005, May)

This paper describes a first step work devoted to applying XFEM and Level Sets methods in optimization of structures. This first step work is based on integrating an existing XFEM code within a general ... [more ▼]

This paper describes a first step work devoted to applying XFEM and Level Sets methods in optimization of structures. This first step work is based on integrating an existing XFEM code within a general open optimization tool, SAMCEF BOSS QUATTRO. Unlike most of the existing works, this approach is more shape optimization oriented. A library of pre-formatted basic geometric entities (such as ellipses, squares, triangles, etc.) described by Level Sets functions are used. These basic Level Set features can be combined to represent many kinds of interfaces and holes. The construction parameters of the basic Level Sets are considered as the design variables. In order to evaluate the sensitivities, a finite difference scheme over the design variables is used in this first work. Different mechanical responses (energy, weight, displacement, . . .) can be considered as objective functions or constraints in the problem formulation. Several academic 2D test cases of shape and topology optimization are presented within the XFEM and Level Set approach. In addition, a work by Missoum et al. [11], in which the shape and topology optimization of the structure is carried out by an optimal selection of holes characteristics with a genetic algorithm is presented. [less ▲]

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See detailOptimization of mechatronic systems: application to a modern car equipped with a semi-active suspension
Duysinx, Pierre ULg; Bruls, Olivier ULg; collard, Jean-François et al

in Herskowitz, José (Ed.) Proceedings of the 6th World Congress of Structural and Multidisciplinary Optimization (WCSMO6) (2005, May)

The research aims at developing a global mechatronic approach to model, simulate and optimize complex industrial applications. The approach is illustrated with the simulation and the optimization of a ... [more ▼]

The research aims at developing a global mechatronic approach to model, simulate and optimize complex industrial applications. The approach is illustrated with the simulation and the optimization of a modern car (an Audi A6) equipped with a controlled semi-active suspension. An optimization procedure is used to find the best sub-system parameters in order to improve the comfort of the passengers while preserving the car ride and handling performances. Two different modeling and optimization approaches are used and compared. The first one is realized in the MATLAB-SIMULINK environment and is based on a symbolic multibody model of the chassis while the hydraulic actuators, and the controller are integrated using S-functions. Optimization is also carried out in MATLAB using algorithms available in MATLAB libraries, especially a genetic algorithm (GA). On the other hand, the second approach relies on a multibody model based on the Finite Element method whereas the optimization can be realized with an industrial open optimization tool. [less ▲]

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See detailImproving TCP in wireless networks with an adaptive machine-learnt classifier of packet loss causes
El Khayat, Ibtissam; Geurts, Pierre ULg; Leduc, Guy ULg

in Lecture Notes in Computer Science (2005, May), 3462

TCP understands all packet losses as buffer overflows and reacts to such congestions by reducing its rate. In hybrid wired/wireless networks where a non negligible number of packet losses are due to link ... [more ▼]

TCP understands all packet losses as buffer overflows and reacts to such congestions by reducing its rate. In hybrid wired/wireless networks where a non negligible number of packet losses are due to link errors, TCP is unable to sustain a reasonable rate. In this paper, we propose to extend TCP Newreno with a packet loss classifier built by a supervised learning algorithm called 'decision tree boosting'. The learning set of the classifier is a database of 25,000 packet loss events in a thousand of random topologies. Since a limited percentage of wrong classifications of congestions as link errors is allowed to preserve TCP-Friendliness, our protocol computes this constraint dynamically and tunes a parameter of the classifier accordingly to maximise the TCP rate. Our classifier outperforms the Veno and Westwood classifiers by achieving a higher rate in wireless networks while remaining TCP-Friendly. [less ▲]

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See detailAn active platform as middleware for services and communities discovery
Martin, Sylvain ULg; Leduc, Guy ULg

in Lecture Notes in Computer Science (2005, May), 3516

In an increasing number of cases, network hosts need to locate a machine based on its role in a service or community rather than based on a well-known address. We propose and evaluate WASP, a lightweight ... [more ▼]

In an increasing number of cases, network hosts need to locate a machine based on its role in a service or community rather than based on a well-known address. We propose and evaluate WASP, a lightweight active platform where ephemeral state left in the network can help locate service providers such as request dispatchers or computation aggregators. In an active grid architecture, WASP can also help locate participants, build and manage overlays. [less ▲]

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