Publications ORBi OA
Bookmark and Share    
Full Text
Peer Reviewed
See detailThe multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5.
Hofland, Leo J.; van der Hoek, Joost; Feelders, Richard et al

in European Journal of Endocrinology (2005), 152(4), 645-654

Objective: Currently, there is no effective medical treatment for patients with pituitary-dependent Cushing’s disease. A novel somatostatin (SS) analogue, named SOM230, with high binding affinity to SS ... [more ▼]

Objective: Currently, there is no effective medical treatment for patients with pituitary-dependent Cushing’s disease. A novel somatostatin (SS) analogue, named SOM230, with high binding affinity to SS receptor subtypes sst1, sst2, sst3 and sst5 was recently introduced. We compared the in vitro effects of the sst2-preferring SS analogue octreotide (OCT) and the multi-ligand SOM230 on ACTH release by human and mouse corticotroph tumour cells. Methods: By quantitative RT-PCR the sst subtype expression level was determined in human corticotroph adenomas. In vitro, the inhibitory effect of OCT and SOM230 on ACTH release by dispersed human corticotroph adenoma cells and mouse AtT20 corticotroph adenoma cells was determined. In addition, the influence of dexamethasone on the responsiveness to OCT and SOM230 was studied. Results: Corticotroph adenomas expressed predominantly sst5 mRNA (six out of six adenomas), whereas sst2 mRNA expression was detected at significantly lower levels. In a 72 h incubation with 10 nmol/l SOM230, ACTH release was inhibited in three out of five cultures (range –30 to –40%). Ten nmol/l OCT slightly inhibited ACTH release in only one of five cultures (– 28%). In AtT20 cells, expressing sst2, sst3 and sst5, SOM230 inhibited ACTH secretion with high potency (IC50 0.2 nmol/l). Dexamethasone (10 nmol/l) pre-treatment did not influence the sensitivity of the cells to the inhibitory effect of SOM230, suggesting that sst5 is relatively resistant to negative control by glucocorticoids. Conclusions: The selective expression of sst5 receptors in corticotroph adenomas and the preferential inhibition of ACTH release by human corticotroph adenoma cells by SOM230 in vitro, suggest that SOM230 may have potential in the treatment of patients with pituitary-dependent Cushing’s disease. [less ▲]

Detailed reference viewed: 26 (2 ULg)
Full Text
See detailA nation-wide project for the revision of the Belgian Nursing Minimum Data Set : from concept to implementation
SERMEUS, Walter; VAN DEN HEEDE, Koen; MICHIELS, Dominik et al

in OUD, Nico; SERMEUS, Walter; EHNFORS, Margareta (Eds.) Proceedings of the fifth biennial European Conference of the Association for Common European Nursing Diagnoses, Interventions and Outcomes (2005, April)

Detailed reference viewed: 20 (1 ULg)
Full Text
See detailCriterion-related validity of the revised Belgian Nursing Minimium Data Set (B-NMDS) throught the actual B-NMDS
THONON, Olivier ULg; VAN BOVEN, Caroline ULg; CODOGNOTTO, Jean ULg et al

in OUD, Nico; SERMEUS, Walter; EHNFORS, Margareta (Eds.) Proceedings of the fifth biennial European Conference of the Association for Common European Nursing Diagnoses, Interventions and Outcomes (2005, April)

Detailed reference viewed: 9 (1 ULg)
Full Text
Peer Reviewed
See detailComment j'explore ... l'hypertension artérielle par excès de minéralocorticoides
Bovy, Christophe ULg; Delanaye, Pierre ULg; Radermecker, Régis ULg et al

in Revue Médicale de Liège (2005), 60(4), 255-63

Primary aldosteronism is a rare cause of hypertension. However, its incidence seems to be underestimated. It is important to identify this syndrom since the disease is potentially curable. In the present ... [more ▼]

Primary aldosteronism is a rare cause of hypertension. However, its incidence seems to be underestimated. It is important to identify this syndrom since the disease is potentially curable. In the present paper, we depict different forms of primary aldosteronism as well as the diagnostic procedures. When the diagnosis is suspected (hypertension associated to spontaneous or diuretic-induced hypokaliemia), the more efficient screening test is the determination of the aldosteron/renin ratio. Saline infusion or posture tests can thereafter confirm the diagnosis. Differential diagnosis between bilateral and unilateral forms of primary aldosteronism can be made by CT-scanner and the response of aldosterone to the posture test. Such a complex assessment leads to the identification of patients who can be surgically treated. This treatment consists in a unilateral adrenalectomy which can be realised by laparoscopy. [less ▲]

Detailed reference viewed: 95 (2 ULg)
Full Text
See detailPsychiatrie de liaison en Unité de Transplantation cardiaque
Triffaux, Jean-Marc ULg

Learning material (2005)

Detailed reference viewed: 35 (2 ULg)
Full Text
See detailApplication of Lempel-Ziv complexity to alignment-free sequence comparison of protein families
Bacha, Sofiène; Baurain, Denis ULg

Poster (2005, April)

Detailed reference viewed: 33 (3 ULg)
Full Text
Peer Reviewed
See detailInflammation et atherosclerose: etat de la question en 2004-2005
Gach, Olivier ULg; Pierard, Luc ULg; Legrand, Victor ULg

in Revue Médicale de Liège (2005), 60(4), 235-41

Inflammation plays a pivotal role in atherosclerosis; being present in all steps of the pathology, from initiation to the progression of the lesions to the development of vulnerable plaques and clinical ... [more ▼]

Inflammation plays a pivotal role in atherosclerosis; being present in all steps of the pathology, from initiation to the progression of the lesions to the development of vulnerable plaques and clinical destabilisation. Therefore, systemic markers of inflammation have emerged to predict future cardiovascular events in patients initially admitted for unstable syndromes, but also in healthy subjects. These markers can identify high risk patients and they are used to adapt ideal treatment to the patient's profile. The implication of the inflammation process in the treatment strategies is described in the last part of the article. [less ▲]

Detailed reference viewed: 12 (0 ULg)
Full Text
Peer Reviewed
See detailHLA-matched unrelated donor hematopoietic cell transplantation after nonmyeloablative conditioning for patients with chronic myeloid leukemia
Baron, Frédéric ULg; Maris, M. B.; Storer, B. E. et al

in Biology of Blood and Marrow Transplantation (2005), 11(4), 272-279

We evaluated 10/10 HLA antigen-matched unrelated hematopoietic cell transplantation (HCT) after nonmyeloablative conditioning with fludarabine 3 x 30 mg/m(2) and 2 Gy of total body irradiation as ... [more ▼]

We evaluated 10/10 HLA antigen-matched unrelated hematopoietic cell transplantation (HCT) after nonmyeloablative conditioning with fludarabine 3 x 30 mg/m(2) and 2 Gy of total body irradiation as treatment for patients with chronic myeloid leukemia who were ineligible for conventional HCT. Data from 21 consecutive patients in first chronic phase (CP1; n = 12), accelerated phase (AP; n = 5), second CP (CP2; n = 3), and blast crisis (n = 1) were analyzed. Stem cell sources were bone marrow (n = 4) or granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells (G-PBMCs; n = 17). The patient who underwent transplantation in blast crisis died on day 21 (too early to be evaluated. for engraftment) from progressive disease. Sustained engraftment was achieved in 5 of 12 patients who underwent transplantation in CP1, 4 of 5 patients who underwent transplantation in AP, and 2 of 3 patients who underwent transplantation in CP2, whereas 9 patients rejected their grafts between 28 and 400 days after HCT. Specifically, I of 4 marrow recipients and 10 of 17 G-PBMC recipients achieved sustained engraftment. Graft rejections were nonfatal in all cases and were followed by autologous reconstitution with persistence or recurrence of chronic myeloid leukemia. Seven of 11 patients with sustained engraftment-including all 5 patients in CP 1, 2 of 4 patients in AP, and neither of the 2 patients in CP2-were alive in complete cytogenetic remissions 118 to 1205 days (median, 867 days) after HCT. Two of the remaining 4 patients died of nonrelapse causes in complete (n = 1) or major (n = 1) cytogenetic remissions, and 2 died of progressive disease. Further efforts are directed at reducing the risk of graft rejection by exclusive use of G-PBMC and increasing the degree of pretransplantation immunosuppression. (c) 2005 American Society for Blood and Marrow Transplantation. [less ▲]

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailThe reconstruction of an Atlantic salmon population in the Belgian River Meuse basin. First success and new threats.
Philippart, Jean-Claude ULg; Ovidio, Michaël ULg; Frank, Vincent et al

Conference (2005, April)

A 'Meuse Salmon' project aiming at restoring an Atlantic salmon run in the River Meuse basin was put forward in 1983 (after the discovery of several 'sea trout' in the Meuse near Liège) and started ... [more ▼]

A 'Meuse Salmon' project aiming at restoring an Atlantic salmon run in the River Meuse basin was put forward in 1983 (after the discovery of several 'sea trout' in the Meuse near Liège) and started officially in 1987 as a contribution of Wallonia to the European Year of Environment. In the course of this programme, most dams (3-8 m in height) obstructing the canalised River Meuse in Belgium and The Netherlands have been fitted with modern fish-ways in order to restore the free circulation of diadromous fish species. A second facet of the Salmon Meuse programme consisted in restocking salmonid streams in the Belgian Ardennes with hatchery reared salmon parr and smolt (maximum 200.000 fish per year) from foreign origins (Scotland, Ireland and France). Returning adult salmon have been scientifically recorded in the Meuse in The Netherlands (estuary and lower course) since 1994 but only since the year 2002 in Belgium: 13 (61-79 cm FL) fish in 2002 and 2 (71-76 cm FL) fish in 2003 caught mostly (13 fish) in a new big fish-pass at the Visé-Lixhe dam and (2 fish) in the River Berwinne, a small tributary of the Meuse known as the last spawning place for S. salar in Belgium in the 1920's. Female and male returning salmon in 2002 were successfully artificially reproduced in order to build a captive freshwater brood stock to be used for production of parrs and smolts of the new Meuse strain next autumn. The communication briefly reports on the progress of the program as concerns the salmon culture for stocking in Wallonia, the population dynamics of stocked parrs in nursery rivers, the patterns of upstream and downstream migration of salmon in the Belgian Meuse and its tributaries and the new challenges to meet (impact on salmon of rising water temperature, development of power generation, increasing predation on smolts by piscivorous birds). [less ▲]

Detailed reference viewed: 54 (5 ULg)
Full Text
Peer Reviewed
See detailA 12-year study of the upstream migration of Anguilla anguilla in a fish-pass in the river Meuse reveals a dramatic decline of the stock in Belgium.
Philippart, Jean-Claude ULg; Ovidio, Michaël ULg; Sonny, Damien

Conference (2005, April)

From 1992 to 2004 upstream migrating eels were collected in a trap (0,5 cm mesh size) installed at the top of a small pool-type fish-pass at the Visé-Lixhe dam (built in 1980 for navigation purposes and ... [more ▼]

From 1992 to 2004 upstream migrating eels were collected in a trap (0,5 cm mesh size) installed at the top of a small pool-type fish-pass at the Visé-Lixhe dam (built in 1980 for navigation purposes and hydropower generation; height : 8,2 m; not equipped with a ship-lock) on the international River Meuse near the Dutch -Belgium border (290 km from the North Sea; width: 200 m; mean annual discharge: 238 m3/s; summer water temperature 21-26°C).The trap in the fish-pass was checked continuously (three times a week) over the migration period from March to September each year, except in 1994. We caught a total number of 32157 eels (biomass 1,955 kg) with a size from 14 cm to 85 cm and a mean value of 31,6 cm corresponding to yellow eels. The study based on a constant year-to-year sampling effort revealed a regular decrease of the annual catch from a maximun of 5613 fish in 1992 to a minimum of 423 in 2004. This demographic trend is fitted by the equation: number per year = 5.614 - 299 t, where t is time in years with 1992 as year 1. According to this model, the upstream migrating yellow eelstock in the Belgian Meuse should drop to near zero within the next ten years, as an expression of a collapsing recruitment of glass eels in the estuary in the Netherlands. In the discussion of these results, we examine the possible role of two other factors on the decrease over time of the number of yellow eels caught in the fish-pass. i) the effect of environmental variables (river discharge, water temperature and dissolved oxygen content) on the timing and intensity of upstream migration waves and ii) the existence and use of alternative migration routes. [less ▲]

Detailed reference viewed: 48 (7 ULg)
Full Text
Peer Reviewed
See detailVivianite formation and distribution in Lake Baikal sediments
Fagel, Nathalie ULg; Alleman, L. Y.; Granina, L. et al

in Global and Planetary Change (2005), 46(1-4), 315-336

In an effort to better understand vivianite formation processes, four Lake Baikal sediment cores spanning two to four interglacial stages in the northern, central and southern basins and under various ... [more ▼]

In an effort to better understand vivianite formation processes, four Lake Baikal sediment cores spanning two to four interglacial stages in the northern, central and southern basins and under various biogeochemical environments are scrutinized. The vivianite-rich layers were detected by anomalous P-enrichments in bulk geochemistry and visually by observations on X-radiographs. The millimetric concretions of vivianite were isolated by sieving and analysed by X-ray diffraction, scanning electron microscope (SEM), microprobe, infrared spectroscopy, inductively coupled plasma atomic emission spectrometry and mass spectrometry (ICP-AES, ICP-MS). All the vivianites display similar morphological, mineralogical and geochemical signature, suggesting a common diagenetic origin. Their geochemical signature is sensitive to secondary alteration where vivianite concretions are gradually transformed from the rim to the center into an amorphous santabarbaraite phase with a decreasing Mn content. We analysed the spatial and temporal distribution of the concretions in order to determine the primary parameters controlling the vivianite formation, e.g., lithology, sedimentation rates, and porewater chemistry. We conclude that vivianite formation in Lake Baikal is mainly controlled by porewater chemistry and sedimentation rates, and it is not a proxy for lacustrine paleoproductivity. Vivianite accumulation is not restricted to areas of slow sedimentation rates (e.g., Academician and Continent ridges). At the site of relatively fast sedimentation rate, i.e., the Posolsky Bank near the Selenga Delta, vivianite production may be more or less related to the Selenga River inputs. It could be also indirectly related to the past intensive methane escapes from the sediments. While reflecting an early diagenetic signal, the source of P and Fe porewater for vivianites genesis is still unclear. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

Detailed reference viewed: 82 (6 ULg)
Full Text
Peer Reviewed
See detailImproved Algorithms for Network Topology Discovery
Donnet, Benoît ULg; Friedman, Timur; Crovella, Mark

in International Workshop on Passive and Active Network Measurement (2005, April)

Topology discovery systems are starting to be introduced in the form of easily and widely deployed software. However, little consideration has been given as to how to perform large-scale topology ... [more ▼]

Topology discovery systems are starting to be introduced in the form of easily and widely deployed software. However, little consideration has been given as to how to perform large-scale topology discovery efficiently and in a network-friendly manner. In prior work, we have described how large numbers of traceroute monitors can coordinate their efforts to map the network while reducing their impact on routers and end-systems. The key is for them to share information regarding the paths they have explored. However, such sharing introduces considerable communication overhead. Here, we show how to improve the communication scaling properties through the use of Bloom filters to encode a probing stop set. Also, any system in which every monitor traces routes towards every destination has inherent scaling problems. We propose capping the number of monitors per destination, and dividing the monitors into clusters, each cluster focusing on a different destination list. [less ▲]

Detailed reference viewed: 30 (3 ULg)
Full Text
Peer Reviewed
See detailSingle-beat evaluation of right ventricular contractility - Reply
Lambermont, Bernard ULg; Segers, P.; D'Orio, Vincenzo ULg

in Critical Care Medicine (2005), 33(4), 918-918

Detailed reference viewed: 24 (5 ULg)
Full Text
Peer Reviewed
See detailTree-based batch mode reinforcement learning
Ernst, Damien ULg; Geurts, Pierre ULg; Wehenkel, Louis ULg

in Journal of Machine Learning Research (2005), 6

Reinforcement learning aims to determine an optimal control policy from interaction with a system or from observations gathered from a system. In batch mode, it can be achieved by approximating the so ... [more ▼]

Reinforcement learning aims to determine an optimal control policy from interaction with a system or from observations gathered from a system. In batch mode, it can be achieved by approximating the so-called Q-function based on a set of four-tuples (x(t), u(t), r(t), x(t+1)) where x(t) denotes the system state at time t, u(t) the control action taken, r(t) the instantaneous reward obtained and x(t+1) the successor state of the system, and by determining the control policy from this Q-function. The Q-function approximation may be obtained from the limit of a sequence of (batch mode) supervised learning problems. Within this framework we describe the use of several classical tree-based supervised learning methods (CART, Kd-tree, tree bagging) and two newly proposed ensemble algorithms, namely extremely and totally randomized trees. We study their performances on several examples and find that the ensemble methods based on regression trees perform well in extracting relevant information about the optimal control policy from sets of four-tuples. In particular, the totally randomized trees give good results while ensuring the convergence of the sequence, whereas by relaxing the convergence constraint even better accuracy results are provided by the extremely randomized trees. [less ▲]

Detailed reference viewed: 363 (46 ULg)
Full Text
Peer Reviewed
See detailL'ischemie aigue des membres: aspects cliniques, diagnostiques et therapeutiques
Van Damme, Hendrik ULg; Limet, Raymond ULg

in Revue Médicale de Liège (2005), 60(4), 247-54

Acute lower limb ischemia, with sudden interruption of tissue perfusion, is a medico-surgical emergency. An early diagnosis is a prerequisite for optimal management. Diagnosis is mainly based on clinical ... [more ▼]

Acute lower limb ischemia, with sudden interruption of tissue perfusion, is a medico-surgical emergency. An early diagnosis is a prerequisite for optimal management. Diagnosis is mainly based on clinical data. Complementary investigations have a limited place, and should not unnecessarily delay the treatment. There are two categories of acute arterial, non-traumatic occlusion: embolism and thrombosis of an atherosclerotic vessel. The distinction between these two entities is not always evident, since ischemia can be the consequence of an arterial embolism in a diseased atherosclerotic artery. We discuss the clinical aspects and the causes of acute lower limb ischemia. The prognosis, outcome and therapeutic management are determined by the cause of the acute arterial obliteration. [less ▲]

Detailed reference viewed: 56 (1 ULg)
Full Text
Peer Reviewed
See detailD-Hormone analog alfacalcidol: an update on its role in post-menopausal osteoporosis and rheumatoid arthritis management
Richy, F.; Deroisy, Rita ULg; Lecart, Marie-Paule ULg et al

in Aging Clinical & Experimental Research (2005), 17(2), 133-142

Alfacalcidol (1-alpha-hydroxyvitamin D is a non-endogenous analog of vitamin D which can bypass the renal and intestinal regulatory mechanisms that control the production of calcitriol (1,25 ... [more ▼]

Alfacalcidol (1-alpha-hydroxyvitamin D is a non-endogenous analog of vitamin D which can bypass the renal and intestinal regulatory mechanisms that control the production of calcitriol (1,25-hydroxyvitamin D-3, the active form of vitamin D, D-Hormone). Alfiacalcidol may be metabolized into calcitriol with a limited risk of hypercalcemia. Alfacalcidol and calcitriol have been evaluated in animal and human studies assessing their effects on bone mineral density and fracture rates. More recently, they have been shown to produce beneficial effects in muscle, immune system, and autoimmune diseases, including rheumatoid arthritis. This paper discusses the therapeutic efficacy of alfacalcidol in reports in which it has been proposed as an interesting alternative to vitamin D or calcitriol. Some recent findings about general metabolism and regulation of vitamin D and its analogs are discussed. The biological and clinical effects of alfacalcidol in post-menopausal osteoporosis are reviewed, followed by critical appraisal of its efficacy in preventing bone loss and falls in the elderly. The lost two sections discuss the role of Danalogs in regulating the immune system, with particular regard to rheumatoid arthritis. The main results of this review show that alfacalcidol may have a wider range of therapeutic applicability, beyond simply restricting it to patients in hemodialysis or peritoneal dialysis with high serum levels of intact PTH. (c) 2005, Editrice Kurtis. [less ▲]

Detailed reference viewed: 84 (9 ULg)
Full Text
Peer Reviewed
See detailHigh-resolution diatom/clay record in Lake Baikal from grey scale, and magnetic susceptibility over Holocene and Termination I
Boes, Xavier; Piotrowska, Natalia; Fagel, Nathalie ULg

in Global and Planetary Change (2005), 46(1-4), 299-313

Tracing past climate signals from Lake Baikal sediments with a "multi-annual' resolution by conventional techniques is a difficult challenge since the sedimentation rates from Termination I up to the ... [more ▼]

Tracing past climate signals from Lake Baikal sediments with a "multi-annual' resolution by conventional techniques is a difficult challenge since the sedimentation rates from Termination I up to the present range from 0.004 to 0.17 mm/year. In this paper, climate signals are reconstructed from three continuous sediment records from Vydrino Shoulder and Posolsky Bank in the Southern Basin, and Continent Ridge in the Northern Basin. For each coring site, a calendar age model was constructed using calibrated radiocarbon ages. The magnetic susceptibility is used to better constrain the age models over OIS4 to OIS1 The cores have been hardened using polymerized technique in order to allow the easy cut of thin sections that contain evidence for narrow biogenic/clayey laminations. The grey scale taken from the thin sections is used here as a high-resolution proxy record of diatom/clay ratio. The grey density values are qualitatively interpreted against the sediment components by optical microscopy from the thin sections. In the Northern Basin, the Continent station provides the best age model and sediment resolution over the Termination I period. In particular, four optima (i.e. Bolling, Allerod, Atlantic, and Subboreal) are indicated by substantial increases of the grey scale, whereas cold periods like the Younger Dryas correspond to lower grey scale values. We emphasize that the short-term variations in the grey scale at 20 mu m resolution could correspond to short climate responses in Lake Baikal sediments. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

Detailed reference viewed: 30 (3 ULg)
Full Text
Peer Reviewed
See detailL'hyperkaliemie, ce nouveau tueur?
Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (2005), 60(4), 222-6

Hyperkalemia is now commonly observed due to several associated factors such as old age, diabetes, congestive heart failure, renal insufficiency and drugs such as spironolactone used to improve cardiac ... [more ▼]

Hyperkalemia is now commonly observed due to several associated factors such as old age, diabetes, congestive heart failure, renal insufficiency and drugs such as spironolactone used to improve cardiac function. Moreover, the easily prescribed new antiinflammatory drugs COX2 selective inhibitors in these patients lead to a very acute risk for vital hyperkalemia development. This review insists on the prevention of such potentially reversible disorder. [less ▲]

Detailed reference viewed: 222 (7 ULg)
Full Text
Peer Reviewed
See detailArray of microsystem for live monitoring of high voltage power lines
Renson, Luc ULg; Jamar, Claude ULg; Guérard, Suzanne ULg et al

in Proceedings of the 1st IOMAC (2005, April)

How to use microsystems placed on power lines environment.

Detailed reference viewed: 128 (15 ULg)