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See detailMise au point d’un protocole de micropropagation in vitro de Jatropha curcas L
Medza Mve, Samson Daudet ULg; Mergeai, Guy ULg; Baudoin, Jean-Pierre ULg et al

in Biotechnologie végétales: amélioration des plantes et sécurité alimentaire» et par le réseau « Biotechnologies Végétales et Biosécurité » du projet SISTBiotechnologies et valorisation du patrimoine végétal sous-exploité en zone sahélienne et soudano-sahélienne (2009, November 14)

Jatropha curcas L. est considéré comme une source potentielle non-comestible pour la production de biocarburants (Sujatha et al, 2005). Sa multiplication par semis présente l’inconvénient de cultiver au ... [more ▼]

Jatropha curcas L. est considéré comme une source potentielle non-comestible pour la production de biocarburants (Sujatha et al, 2005). Sa multiplication par semis présente l’inconvénient de cultiver au champ des plantes hétérogènes, dont les graines présentent des contenus en huile qui varie de 4-40% (Heller, 1996). La présente étude vise la mise au point d’un protocole de multiplication massale de plantes élites à partir d’explants nodaux cultivés en conditions axéniques. [less ▲]

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See detailVehicle loading optimization with stochastic supply
Pironet, Thierry ULg

Scientific conference (2009, November 13)

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See detailThe dashundergaps package
Merciadri, Luca ULg

Computer development (2009)

This is the manual of the dashundergaps package that I wrote. Briefly, this package aims at helping the LaTeX user at underlining a given set of words by either a line (using \underline{text}), dots ... [more ▼]

This is the manual of the dashundergaps package that I wrote. Briefly, this package aims at helping the LaTeX user at underlining a given set of words by either a line (using \underline{text}), dots (using \dotuline{text}) or even a dashed line (using \dashuline{text}). Various options were implemented for this. This can be used in conjunction with the phantomtext option, which allows the user to write a text with gaps, e.g. for a completion by students. These gaps can be completed with the real input using the teachernotes option. Please note that this is a really basic package. For more info on it, please look at the manual in the tarball. [less ▲]

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See detailMultidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells.
Wu, Shuangding; Vossius, Sofie ULg; Rahmouni, Souad ULg et al

in Journal of Medicinal Chemistry (2009), 52(21), 6716-23

Loss of VHR phosphatase causes cell cycle arrest in HeLa carcinoma cells, suggesting that VHR inhibition may be a useful approach to halt the growth of cancer cells. We recently reported that VHR is ... [more ▼]

Loss of VHR phosphatase causes cell cycle arrest in HeLa carcinoma cells, suggesting that VHR inhibition may be a useful approach to halt the growth of cancer cells. We recently reported that VHR is upregulated in several cervix cancer cell lines as well as in carcinomas of the uterine cervix. Here we report the development of multidentate small-molecule inhibitors of VHR that inhibit its enzymatic activity at nanomolar concentrations and exhibit antiproliferative effects on cervix cancer cells. Chemical library screening was used to identify hit compounds, which were further prioritized in profiling and kinetic experiments. SAR analysis was applied in the search for analogs with improved potency and selectivity, resulting in the discovery of novel inhibitors that are able to interact with both the phosphate-binding pocket and several distinct hydrophobic regions within VHR’s active site. This multidentate binding mode was confirmed by X-ray crystallography. The inhibitors decreased the proliferation of cervix cancer cells, while growth of primary normal keratinocytes was not affected. These compounds may be a starting point to develop drugs for the treatment of cervical cancer. [less ▲]

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See detailSensitivity analysis on the elastic buckling and ultimate strength of continuous stiffened aluminium plates under combined in-plane compression and lateral pressure
Khedmati, Mohammad Reza; Zareei, Mohammad Reza; Rigo, Philippe ULg

in Thin-Walled Structures (2009), 47

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See detailAbusive margin squeeze: an overview of European national case laws
Petit, Nicolas ULg; Provost, Elise ULg

in e-Competitions (2009)

The purpose of this brief article is to introduce the reader to the national case-law on abusive margin squeezes that was commented in the e-competitions bulletin over the period 2003-2009.To this end, it ... [more ▼]

The purpose of this brief article is to introduce the reader to the national case-law on abusive margin squeezes that was commented in the e-competitions bulletin over the period 2003-2009.To this end, it seeks, to the extent possible, to analyze the 23 e-competitions case notes in relation to six items which are generally reviewed in margin squeeze cases, i.e., existence of an upstream input and a downstream product/service (1); indispensability of the upstream input (2); dominance in the upstream market and vertical integration (3); particularly aggressive downstream pricing policy (4); anticompetitive effects (5); absence of objective justifications (6). In addition, the present article reviews a seventh issue, namely sanctions and remedies (7), where national enforcement practices may again diverge/converge. [less ▲]

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See detailKu proteins interact with activator protein-2 transcription factors and contribute to ERBB2 overexpression in breast cancer cell lines.
Nolens, Grégory ULg; Pignon, Jean-Christophe ULg; Koopmansch, Benjamin ULg et al

in Breast Cancer Research [=BCR] (2009), 11(6),

INTRODUCTION: Activator protein-2 (AP-2) alpha and AP-2 gamma transcription factors contribute to ERBB2 gene overexpression in breast cancer. In order to understand the mechanism by which the ERBB2 gene ... [more ▼]

INTRODUCTION: Activator protein-2 (AP-2) alpha and AP-2 gamma transcription factors contribute to ERBB2 gene overexpression in breast cancer. In order to understand the mechanism by which the ERBB2 gene is overexpressed we searched for novel AP-2 interacting factors that contribute to its activity. METHODS: Ku proteins were identified as AP-2 alpha interacting proteins by glutathione serine transferase (GST)-pull down followed by mass spectrometry. Transfection of the cells with siRNA, expression vectors and reporter vectors as well as chromatin immunoprecipitation (ChIP) assay were used to ascertain the implication of Ku proteins on ERBB2 expression. RESULTS: Nuclear proteins from BT-474 cells overexpressing AP-2 alpha and AP-2 gamma were incubated with GST-AP2 or GST coated beads. Among the proteins retained specifically on GST-AP2 coated beads Ku70 and Ku80 proteins were identified by mass spectrometry. The contribution of Ku proteins to ERBB2 gene expression in BT-474 and SKBR3 cell lines was investigated by downregulating Ku proteins through the use of specific siRNAs. Depletion of Ku proteins led to downregulation of ERBB2 mRNA and protein levels. Furthermore, reduction of Ku80 in HCT116 cell line decreased the AP-2 alpha activity on a reporter vector containing an AP-2 binding site linked to the ERBB2 core promoter, and transfection of Ku80 increased the activity of AP-2 alpha on this promoter. Ku siRNAs also inhibited the activity of this reporter vector in BT-474 and SKBR3 cell lines and the activity of the ERBB2 promoter was further reduced by combining Ku siRNAs with AP-2 alpha and AP-2 gamma siRNAs. ChIP experiments with chromatin extracted from wild type or AP-2 alpha and AP-2 gamma or Ku70 siRNA transfected BT-474 cells demonstrated Ku70 recruitment to the ERBB2 proximal promoter in association with AP-2 alpha and AP-2 gamma. Moreover, Ku70 siRNA like AP-2 siRNAs, greatly reduced PolII recruitment to the ERBB2 proximal promoter. CONCLUSIONS: Ku proteins in interaction with AP-2 (alpha and gamma) contribute to increased ERBB2 mRNA and protein levels in breast cancer cells. [less ▲]

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See detailActivités de l'unité de Chimie Biologique Industrielle
Jacquet, Nicolas ULg; Paquot, Michel ULg

Speech/Talk (2009)

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See detailEtude chromatographique de substances volatiles: cas des sémiochimiques
Heuskin, Stéphanie ULg

Scientific conference (2009, November 10)

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See detailDiploma thesis presentation
Léonard, Grégoire ULg

Scientific conference (2009, November 09)

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See detailStudy of Carbon Fibre-Reinforced Magnesium Composites (Introduction to interfacial phenomenon)
Montrieux, Henri-Michel ULg; Lecomte-Beckers, Jacqueline ULg

Conference (2009, November 06)

Composite materials are known to combine interesting properties of different materials. This research concerns magnesium alloys reinforced by carbon fibres weaves. Such a material can theoretically ... [more ▼]

Composite materials are known to combine interesting properties of different materials. This research concerns magnesium alloys reinforced by carbon fibres weaves. Such a material can theoretically exhibit a yield strength/density ratio around 500 compared to ~200 for Ti6Al4V and ~125 for Al2024-T6. This composite is thought to be especially promising for aeronautics if interaction between fibres and magnesium can be controlled and optimized. The strategy studied to enhance interaction between matrix and fibres consists in covering a thin layer of carbide former metal (Zr, Ti) by PVD as a primary treatment of carbon weaves. This intermediate product can then be heated up between 300-700°C in an argon atmosphere in order to form stable carbides. The wetability of treated weaves by liquid magnesium is potentially higher because carbides are not fully covalent (partially metallic) and so they can have more interface interaction with liquid metals. Further crystal lattice parameters of particular carbides can be close to the ones of metal crystal lattices and interface energy can consequently be reduced when they form carbide-metal bonds. Furthermore magnesium is known for its high oxygen attraction and is able to reduce a lot metallic oxides. It is a key fact because liquid magnesium easy wets its oxide in certain conditions. [less ▲]

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See detailToepassingsgebiet ontwerpsoftware
Franssen, Jean-Marc ULg

Conference given outside the academic context (2009)

This Powerpoint presentation compares the results provided by the simple calculation model and the general calculation model for the calculation of the fire resistance of simple structural members ... [more ▼]

This Powerpoint presentation compares the results provided by the simple calculation model and the general calculation model for the calculation of the fire resistance of simple structural members subjected to fire. [less ▲]

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See detailProduction de viande - environnement : levons les équivoques !
Beckers, Yves ULg

Conference (2009, November 05)

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See detailCarcass chilling in large cattle from the Belgian Blue Breed : time-temperature evolution and recommendations
Collignon, Bertrand; Dehard, Sandrine; Clinquart, Antoine ULg

Poster (2009, November 05)

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See detailMai 68 : un héritage clivé
Frère, Bruno ULg

in Revue du MAUSS (2009)

Tout le monde aura entendu ou lu dans la presse la façon dont l'actuel président français, initiateur d'une révolution conservatrice sans précédent en France, fustige l'esprit de 68. L'on pourrait s ... [more ▼]

Tout le monde aura entendu ou lu dans la presse la façon dont l'actuel président français, initiateur d'une révolution conservatrice sans précédent en France, fustige l'esprit de 68. L'on pourrait s'amuser d'un tel positionnement campé par un politicien qui, par ailleurs, n'a guère rechigné à afficher le comportement amoureux léger qu'on lui connaît et que n'auraient pas désavoués les étudiant(e)s de mai lorsqu'ils étaient sur les barricades, aux prises avec le conservatisme français en matière de moeurs. Mais mon propos sera ici d'une autre nature, bien qu'il s'inscrive dans un étonnement similaire face aux diatribes de Nicolas Sarkozy. En effet, il est probablement un second élément qui rappelle ce dernier au souvenir de cette révolution dont il veut « liquider l'héritage » : la pensée économique « libertarienne », née, pour sa déclinaison française, de l'improbable union entre l'esprit frondeur et libertaire de 68 et l'économie de marché [less ▲]

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