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See detailLa sécurité alimentaire des produits fermiers
Belleflamme, Christel ULg

Article for general public (2005)

Le 14 novembre 2003, l’Arrêté Royal relatif à l’autocontrôle, à la notification obligatoire et à la traçabilité dans la chaîne alimentaire a été adopté. Cet arrêté rappelle l’obligation d’appliquer un ... [more ▼]

Le 14 novembre 2003, l’Arrêté Royal relatif à l’autocontrôle, à la notification obligatoire et à la traçabilité dans la chaîne alimentaire a été adopté. Cet arrêté rappelle l’obligation d’appliquer un système d’autocontrôle pour la transformation et la distribution des produits, obligation déjà présente dans l’Arrêté Royal du 7 mars 1994 relatif à l’agrément des établissements laitiers et des acheteurs. Il contient des exigences supplémentaires concernant la production primaire, la traçabilité et la notification obligatoire. Ces arrêtés peuvent s’adapter aux plus petites structures. Certaines dérogations en matière d’infrastructure sont possibles pour les petites entreprises pour autant que ces dérogations ne nuisent pas à l’hygiène des produits. pour les très petites entreprises. [less ▲]

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See detailA phase II study of paclitaxel in advanced bronchioloalveolar carcinoma (EORTC trial 08956)
Scagliotti, G. V.; Smit, E.; Bosquee, Léon ULg et al

in Lung Cancer (2005), 50(1), 91-96

Purpose: The incidence of bronchioloalveolar carcinoma (BAC) has risen steadily over the last decades along with the increasing frequency of adenocarcinomas. BAC is relatively resistant to commonly used ... [more ▼]

Purpose: The incidence of bronchioloalveolar carcinoma (BAC) has risen steadily over the last decades along with the increasing frequency of adenocarcinomas. BAC is relatively resistant to commonly used chemotherapy regimens. A phase 11 study with single agent pactitaxel in patients with stages IIIB, IV or recurrent BAC was performed. Experimental design: Patients with BAC with at least one target bidimensionally measurable lesion staged as unresectable stages IIIB, IV or recurrent disease, not previously irradiated; ECOG performance status 0-2; life expectancy greater than 3 months; age range between 18 and 75, received pactitaxel at a dose of 200 mg/m(2) i.v. as 3 h continuous infusion on day 1 every 21 days. Treatment was continued until progression or up to a maximum of six cycles. Results: Nineteen patients were eligible. Median number of cycles was 3 (range 0-6); 35% of patients received the planned six cycles of chemotherapy. One patient died of unrelated cause before the start of treatment. Both hematological and non-hematological toxicities were generally mild. Only one partial response (PR) was observed among the 18 eligible patients who started protocol treatment, with a response rate of 5.6% (95% Cl: 0.1-27.3%). After an independent review, two PR were confirmed, for a response rate of 11.1% (95% CI: 1.4-34.7%); nine patients had stable disease (50.0%), three patients had progressive disease (11.1%) and four patients were not assessable (22.2%). Median survival was 8.6 months (95% CI: 5.8-14.5) and 1-year survival was 35.0% (95% CI: 14.1-55.8). Median progression free survival for all patients was 2.2 months (95% CI: 1.5-6.0). The study was terminated due to the low response rate. Conclusions: Pactitaxel as single agent in stages IIIB-IV BAC was well tolerated and manageable but of limited efficacy. BAC should not be excluded from trials of new forms of chemotherapy. (c) 2005 Elsevier Ireland Ltd. All rights reserved. [less ▲]

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See detailInfection a polyomavirus BK apres transplantation renale
Bonvoisin, Catherine ULg; Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (2005), 60(10), 775-82

Beside acute rejection or immunosuppressive therapy toxicity, infection by Polyomavirus BK, usually not aggressive in immunoactive patients, has emerged as an important factor affecting graft function in ... [more ▼]

Beside acute rejection or immunosuppressive therapy toxicity, infection by Polyomavirus BK, usually not aggressive in immunoactive patients, has emerged as an important factor affecting graft function in renal transplant recipients. Indeed, one of the most important complications of BK infection is nephropathy. Viral replication in the urinary tract as assessed by the presence of "decoy cells", or by a positive PCR for BK virus has been detected in up to half of the recipients but only 5% will present nephropathy which is usually the only sign. The most common risk factors for this emerging new cause are new immunosuppressive drugs and rejection episodes. The gold standard to diagnose BK nephropathy is immunohistochemical staining for large T antigen in graft biopsy specimens. Urine cytology examination and DNA BK PCR are used as a screening test. The prognosis in BK nephropathy has been considered to be poor. The early reduction of immunosuppression can improve the prognosis and perhaps also cidofovir or leflunomide use. [less ▲]

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See detailPremière démonstration d'une supériorite des agents antihypertenseurs modernes par rapport aux molécules plus anciennes dans la prévention cardio-vasculaire : résultats du bras "abaissement de pression artérielle" de l'étude ASCOT
Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (2005), 60(10), 820-826

In the antihypertensive population, a normalisation of blood pressure level must be the first objective. The Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) - Blood Pressure lowering arm again confirms ... [more ▼]

In the antihypertensive population, a normalisation of blood pressure level must be the first objective. The Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) - Blood Pressure lowering arm again confirms this assertion. The benefit has been proportional to the blood pressure decrease. However, the use of newest antihypertensive drugs (the long acting dihydropyridine calcium antagonist amlodipine very often associated to the ACE inhibitor perindopril) in the hypertensive population aged from 40 to 79 years with at least 3 additional risk factors showed significantly lower rates of cardiovascular and total mortalities, cardiovascular events, new diabetes or renal impairment as compared to the atenolol-based combination drug regimen (with thiazide as required). It should be noted that almost all the patients also received a low dose of a hypolipidemic drug, atorvastatin. Both arms (the statin arm and the arm using antihypertensive drugs) have yet been stopped, after 3 and 5 years, respectively related to the large beneficial effects noted with the new antihypertensive and statin treatments, although the primary endpoints (non fatal myocardial infarctival and fatal coronary heart disease) were not reached. This study raises many unsolved questions about the explanation for such benefits or the future management of the hypertensive people whose characteristics were very similar to those people frequently encountered in clinical practice. However, the present study emphasizes the considerable efficacy of a combination of amlodipine-perindopril and a low dose of statin. [less ▲]

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See detailRapid diabetes onset and its reversal among patients treated with second generation antipsychotics
De Hert, M.; Van Eyck, D.; Hanssens, L. et al

in European Neuropsychopharmacology (2005, October), 15(Suppl. 3), 483-484

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See detailSix-month incidence of diabetes among schizophrenic patients in Belgium
Hanssens, L.; De Hert, M.; Van Eyck, D. et al

in European Neuropsychopharmacology (2005, October), 15(Suppl. 3), 483

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See detailTreating verbal short-term memory deficits by increasing the duration of temporary phonological representations : a case study
Majerus, Steve ULg; Van Der Kaa, M. A.; Renard, Cécile ULg et al

in Brain & Language (2005), 95(1), 174-175

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See detailTemporalités et territorialités dans la dynamique des réseaux, l'exemple du programme régional de la santé des jeunes
Absil, Gaëtan ULg; Vandoorne, Chantal ULg; Demarteau, Michel

in Territoire, bien-être et inclusion sociale - Résumés des communications (2005, October)

Summary : Territories and times are significant factors in networks management and efficacy. Tools should be designed to survey if networking is appropriate for a project in a particular setting.

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See detailReview of the use of Peclet numbers to determine the relative importance of advection and diffusion in low permeability environments
Huysmans, Marijke; Dassargues, Alain ULg

in Hydrogeology Journal (2005), 13(5-6), 895-904

In low permeability environments, transport by advection is often neglected based on a Peclet number criterion. Such a criterion usually states that if the Peclet number (Pe) is much smaller than 1 ... [more ▼]

In low permeability environments, transport by advection is often neglected based on a Peclet number criterion. Such a criterion usually states that if the Peclet number (Pe) is much smaller than 1, diffusion dominates over advection and transport may be modeled considering diffusion only. Unfortunately, up to 10 different Peclet number definitions exist and for a particular case these different definitions lead to very diverse Peclet number values, differing several orders of magnitude from each other. In this paper, the different Peclet number definitions are therefore evaluated on their ability to determine the relative importance of transport by advection and by diffusion in low permeability environments. This is done by comparing the results of the analytical solution for pure diffusion with the analytical solution for diffusion, advection and dispersion for a large number of different input parameter values. The relation between the different Peclet numbers and the difference between the calculated concentration considering diffusion only and the calculated concentration considering both diffusion and advection is studied. These calculations show that some Peclet number definitions are not well suited to decide whether advection may be neglected in low permeability media. [less ▲]

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See detailComparing traffic engineering objective functions
Balon, Simon ULg; Skivée, Fabian; Leduc, Guy ULg

in CoNext 2005 - Student Workshop (2005, October)

We compare and evaluate how well-known and novel network-wide objective functions for Traffic Engineering (TE) algorithms fulfil TE requirements. To compare the objective functions we model the TE problem ... [more ▼]

We compare and evaluate how well-known and novel network-wide objective functions for Traffic Engineering (TE) algorithms fulfil TE requirements. To compare the objective functions we model the TE problem as a linear program and solve it to optimality, thus finding for each objective function the best possible target of any heuristic TE algorithm. Our first results suggest that they can give quite different results. [less ▲]

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See detailHedge fund performance and persistence in bull and bear markets
Capocci, Daniel; Corhay, Albert ULg; Hübner, Georges ULg

in European Journal of Finance (2005), 11(5), 361-392

This paper tests the performance of 2894 hedge funds in a time period that encompasses unambiguously bullish and bearish trends whose pivot is commonly set at March 2000. The database proves to be fairly ... [more ▼]

This paper tests the performance of 2894 hedge funds in a time period that encompasses unambiguously bullish and bearish trends whose pivot is commonly set at March 2000. The database proves to be fairly trustable with respect to the most important biases in hedge funds studies, despite the high attrition rate of funds observed in the down market. An original ten-factor composite performance model is applied that achieves very high significance levels. The analysis of performance indicates that most hedge funds significantly outperformed the market during the whole test period, mostly thanks to the bullish subperiod. In contrast, no significant underperformance of individual hedge funds strategies is observed when markets headed south. The analysis of persistence yields very similar results, with most of the predictability being found among middle performers during the bullish period. However, the "Market Neutral" strategy represents a remarkable exception, as abnormal performance is sustained throughout and significant persistence can be found between the 20% and 69% best performers in this category, probably thanks to an extreme adaptability and a very active investment behaviour.(Abstract EconLit copié le 29/06/06) [less ▲]

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See detailDétournement d'un outil formatif en 1ère année universitaire
Minet, Vincent; Palm, Rodolphe ULg

Conference (2005, October)

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See detailModulation of angiogenesis during adipose tissue development in murine models of obesity.
Vörös, Gabor; Maquoi, Erik ULg; Demeulemeester, Diego et al

in Endocrinology (2005), 146(10), 4545-4554

Development of vasculature and mRNA expression of 17 pro- or antiangiogenic factors were studied during adipose tissue development in nutritionally induced or genetically determined murine obesity models ... [more ▼]

Development of vasculature and mRNA expression of 17 pro- or antiangiogenic factors were studied during adipose tissue development in nutritionally induced or genetically determined murine obesity models. Subcutaneous (SC) and gonadal (GON) fat pads were harvested from male C57Bl/6 mice kept on standard chow [standard fat diet (SFD)] or on high-fat diet for 0-15 wk and from male ob/ob mice kept on SFD. Ob/ob mice and C57Bl/6 mice on high-fat diet had significantly larger SC and GON fat pads, accompanied by significantly higher blood content, increased total blood vessel volume, and higher number of proliferating cells. mRNA and protein levels of angiopoietin (Ang)-1 were down-regulated, whereas those of thrombospondin-1 were up-regulated in developing adipose tissue in both obesity models. Ang-1 mRNA levels correlated negatively with adipose tissue weight in the early phase of nutritionally induced obesity as well as in genetically determined obesity. Placental growth factor and Ang-2 expression were increased in SC adipose tissue of ob/ob mice, and thrombospondin-2 was increased in both their SC and GON fat pads. mRNA levels of vascular endothelial growth factor (VEGF)-A isoforms VEGF-B, VEGF-C, VEGF receptor-1, -2, and -3, and neuropilin-1 were not markedly modulated by obesity. This modulation of angiogenic factors during development of adipose tissue supports their important functional role in obesity. [less ▲]

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See detailPourquoi tant de flux d’élèves dans les écoles en discrimination positive
Bouchat, Thérèse-Marie; Hindryckx, Geneviève ULg

Conference (2005, October)

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See detailIsocinétisme et pathologie musculaire traumatique
Croisier, Jean-Louis ULg

in Annales de Réadaptation et de Médecine Physique (2005, October), 48(7), 511

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See detailExploration isocinétique des rotateurs de l’épaule : analyse critique
Forthomme, Bénédicte ULg; Crielaard, Jean-Michel ULg; Croisier, Jean-Louis ULg

in Annales de Réadaptation et de Médecine Physique (2005, October), 48(7), 510

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See detailGeneralized shape optimization using XFEM and Level Set methods
Duysinx, Pierre ULg; Van Miegroet, Laurent ULg; jacobs, Thibaut et al

in Bendsoe, M.-P.; Olhoff, N.; Sigmund, O. (Eds.) Proceedings of Topopt SYMP2005, IUTAM Symposium. Topological Design Optimization of Structures, Machines and Materials. Status and Perspectives (2005, October)

This paper presents an intermediate approach between parametric shape optimization and topology optimization. It is based on using the recent Level Set description of the geometry and the novel eXtended ... [more ▼]

This paper presents an intermediate approach between parametric shape optimization and topology optimization. It is based on using the recent Level Set description of the geometry and the novel eXtended Finite Element Method (XFEM). The method takes benefit of the fixed mesh work using X-FEM and of the curves smoothness of the Level Set description. Design variables are shape parameters of basic geometric features. The number of design variables of this formulation is small whereas various global and local constraints can be considered. The Level Set description allows to modify the connectivity of the structure as geometric features can merge or separate from each other. However no new entity can be introduced. A central problem that is investigated here is the sensitivity analysis and the way it can be carried out efficiently. Numerical applications revisit the classical elliptical hole benchmark from shape optimization. [less ▲]

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See detailStructure cordale et pathologies vocales
FINCK, Camille ULg

in Revue de Laryngologie - Otologie - Rhinologie (2005, October), (126,5), 295-300

Communication présentée lors du LXIième congrès de la Société Française de Phoniatrie et des Pathologies de la Communication; Paris, le 9 octobre 2005. Our knowledge of vocal fold structure has profoundly ... [more ▼]

Communication présentée lors du LXIième congrès de la Société Française de Phoniatrie et des Pathologies de la Communication; Paris, le 9 octobre 2005. Our knowledge of vocal fold structure has profoundly evolved since the description by M.Hirano in 1974 of the laminar organization of the connective tissue of the human vocal fold , the lamina propria. The molecular composition of the extracellular matrix (ECM) of the lamina propria is essential in determining the viscoelastic properties of the tissue. This is particularly true in the superficial layer of the lamina propria ( also called Reinke’s space). With the epithelium, Reinke’s space constitutes the vocal fold main vibrator. In normal subjects, the jelly like structure of the Reinke’s space is due to a very loose fibrous scaffolding and to a balance between the interstitial proteins of the ECM : proteoglycans like decorin and hyaluronic acid and glycoproteins like fibronectin. Vibratory trauma leads , in disease states , to molecular modification of the extracellular matrix of Reinke’s space resulting in benign cordal lesions like nodules, submucosal fibrosis and vocal folds scars. Improving the knowledge of the homeostasis of Reinke’s space ECM can lead to improvement of the therapeutic and prevention strategies of vocal fold benign lesions. The main histologic and viscoelastic characteristics, as well as surgical treatment of cordal nodular lesions and scars are described. The recent researches in the field of regeneration of Reinke’s space are evoked. Rappel des connaissances de la microstructure cordale normale( et en particulier de la structure laminaire de la corde vocale ainsi que la répartition particulière des protéo- et glycosaminoglycans) , de l'altération de celle-ci en cas de nodule cordal et de cicatrice cordale. Implications thérapeutiques en terme de technique microchirurgicale, en particulier implantation d'acide hyaluronique estérifié dans la plaie microchirurgicale afin de moduler le processus de cicatrisation [less ▲]

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