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See detailRéflexions sur l'idée de la "confiance mutuelle"
Flore, Daniel ULg

in L'espace pénal européen (2003)

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See detailUn droit pénal européen : hasard ou nécessité
Flore, Daniel ULg

in Revue de Droit Pénal et de Criminologie (2003), 9

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See detailTemporal variability of neurography
WANG, François-Charles ULg; Horward, Alain

in Journal of Neurology (2003)

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See detailInfluence of Empirical Antibiotic (AB) Policy for Suspected Early-Onset Infection on the Bacterial Epidemiology in a Neonatal Unit
Egedy, Maude; Rousseaux, Dany; Maton, Pierre et al

in Mindcull.com/pediatric academic societies annual meeting (2003)

BACKGROUND: The worldwide epidemiology of causative bacteriae in early-onset infection has been remarkably stable along the last decades.Widespread use of broad-spectrum ABs for early-onset infection in ... [more ▼]

BACKGROUND: The worldwide epidemiology of causative bacteriae in early-onset infection has been remarkably stable along the last decades.Widespread use of broad-spectrum ABs for early-onset infection in neonates (N) can select multi-resistant bacteriae. OBJECTIVE: We postulated that switching from Ampicillin (A) to Penicillin G (PG) for suspected early-onset infection in our three levels neonatal units, wathever the gestational age, could modify the selective pressure among Enterobacteriacae (EB) and decrease emergence of resistant inducible bacteriae. DESIGN/METHODS: This is a prospective bacteriological survey of 22 months comparing three successive time-periods (P1,2,3) reflecting a progressive switching from Ampicillin-Amikacin (A-Ak) to Penicillin G-Amikacin (PG-Ak). It accounts for respectively A-Ak and PG-Ak (%) : P1 : (66 and 34); P2 : (48 and 52); P3 : (12 and 88). Systematic bacterial screening included blood culture and multiple swabs on admission. Multiple swabs and faeces culture were repeated once a week. Additional cultures were taken when clinically indicated. Antibiograms were done with the Viteck2 System (Biomerieux). Data were collected on the Bacteriological logicial Infopartner R (Nancy). RESULTS: Antenatal AB policy was not modified along the survey. We included 334, 340 and 306 N for P1, P2 and P3, respectively with the same proportion of very preterms. The neonatal morbidity was similar between the three Ps. In respect to the bacteriological screening, no major differences in the proportion of bacterial groups were observed. However, the proportion of inducible EB significantly decreased between the P1 and the P3 (39.7% vs 21.7%, p [less ▲]

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See detailModeling tracer injection and well-aquifer interactions: A new mathematical and numerical approach
Brouyère, Serge ULg

in Water Resources Research (2003), 39(3),

[1] A new mathematical and numerical approach is presented to model solute exchange between a well and the surrounding aquifer for the interpretation of field tracer tests. On the basis of water and ... [more ▼]

[1] A new mathematical and numerical approach is presented to model solute exchange between a well and the surrounding aquifer for the interpretation of field tracer tests. On the basis of water and tracer mass balance equations integrated over the volume of water in the well, the approach allows for finite volumes of tracer fluid and water flush. It deals with tracer mixing and capturing in the well bore, local distortion of the flow field around the well, and possible tracer back-migration into the well. A numerical solution, implemented in the three-dimensional finite element groundwater flow and transport simulator SUFT3D, is proposed that allows for modeling nonuniform distributions of tracer mass fluxes along the well screens related to variations in aquifer hydraulic conductivity. Showing its ability to reproduce concentration evolutions monitored in a well during field tracer experiments, considering various injection conditions, validates the approach. [less ▲]

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See detailSpeed of sound measurements in the evaluation of bone properties in Holstein-Friesian cows: a preliminary study
Sandersen, Charlotte ULg; Guyot, Hugues ULg; Vandeputte, Sébastien ULg et al

in Acta Veterinaria Scandinavica. Supplementum (2003), (Suppl 97), 149

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See detailSymetrie et reproductibilite temporelle des donnees neurographiques.
Bouquiaux, Olivier ULg; Horward, A.; Wang, François-Charles ULg

in Neurophysiologie Clinique = Clinical Neurophysiology (2003), 33(4), 185-95

The aims of the present study are to document side-to-side differences and temporal variability, between two trials (T1 and T2 at a time interval of 3 months) of nerve conduction measurements collected ... [more ▼]

The aims of the present study are to document side-to-side differences and temporal variability, between two trials (T1 and T2 at a time interval of 3 months) of nerve conduction measurements collected from 30 healthy subjects (mean age 22 +/- 2 years). METHODS: The protocol at T1 consisted of motor nerve conduction studies of median, ulnar, peroneal and tibial nerves bilaterally, with measurement of (a) motor response size (amplitude and area); (b) terminal latency; (c) minimal, mean and maximal F-wave latency; (d) motor conduction velocity; and (e) F-wave occurrence. T1 also involved sensory nerve conduction studies of median, ulnar, radial, lateral and medial cutaneous, sural and superficial peroneal nerves bilaterally, with measurement of sensory potential size (amplitude and area) and computation of sensory conduction velocity. The protocol at T2 consisted of identical measurements from the dominant side. RESULTS AND CONCLUSION: There was a negative relationship between the variability of parameters evaluating nervous conduction and the length of the nerve segment under study. Thus, the smallest side-to-side and temporal variabilities are measured for minimal F-wave latencies (on average 2-3%). The limits of symmetry and temporal variability are particularly useful for diagnosis of unilateral peripheral neuropathy or neurophysiological follow-up of patients with neuropathy, when the variability of the parameter under study is weak and when there is a high correlation between values recorded on the left and on the right or at T1 and T2. This was the case for motor response size of tibial and ulnar nerves, sensory potential size of radial nerve and minimal F-wave latencies from each studied motor nerve. [less ▲]

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See detailAnatomical and histological aspects of the tonsils in sheep
Gabriel, Annick ULg; Cocquyt, G.; Van den Broeck, W.

in Annales de Médecine Vétérinaire (2003), 147(4, AUG-SEP), 251-258

Since the 1st April 2002, the European Union has extended the Transmissible Spongiform Encephalopathy testing in ruminants by including sheep and goats in the survey studies. In small ruminants, presence ... [more ▼]

Since the 1st April 2002, the European Union has extended the Transmissible Spongiform Encephalopathy testing in ruminants by including sheep and goats in the survey studies. In small ruminants, presence of the agent of Bovine Spongiform Encephalopathy was demonstrated in tonsils, so these are considered as specified risk materials. This article gives an overview of the anatomical localisation and histological structure of the tonsils in small ruminants. Anatomically, 6 different tonsils can be distinguished: 3 are located in the oropharyngeal tract (tonsilla palatina, tonsilla lingualis, tonsilla veli palatini), 2 in the nasopharyngeal tract (tonsilla pharyngea and tonsilla tubaria), and one in the laryngopharyngeal tract (tonsilla paraepiglottica). Several tonsils show a cryptic overlying epithelium (cryptic tonsil) whereas other don't (non-cryptic tonsil). Several immunological features of the tonsils are described. [less ▲]

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See detailDiagnostic différentiel des troubles à expression nerveuse dans l’espèce bovine en Europe occidentale
Saegerman, Claude ULg; Claes, L.; Dewaele, A. et al

in Revue Scientifique et Technique (International Office of Epizootics) (2003), 22(1), 61-82

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See detailAnatomische, histologische en immunologische aspecten van de tonsille bij het schaap in het kader van de BSE problematiek
Cocquyt, G.; Gabriel, Annick ULg; Van den Broeck, W.

in Vlaams Diergeneeskundig Tijdschrift (2003), 72

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See detailGrowth hormone (GH) secretion in patients with childhood-onset GH deficiency: Retesting after one year of therapy and at final height
Thomas, Muriel; Massa, Guy; Maes, Maes et al

in Hormone Research (2003), 59(1), 7-15

Background. Recent studies have shown that many patients treated with growth hormone (GH) during childhood because of idiopathic GH deficiency (GHD) are no longer GH deficient when retested after ... [more ▼]

Background. Recent studies have shown that many patients treated with growth hormone (GH) during childhood because of idiopathic GH deficiency (GHD) are no longer GH deficient when retested after cessation of GH therapy when final height is achieved. These patients are labelled as transient GHD. We hypothesized that normalization of GH secretion in transient GHD could occur earlier during the course of GH treatment, which could allow earlier cessation of GH treatment. Methods: In a retrospective study, GH secretion was re-evaluated after cessation of GH treatment at final height in 43 patients diagnosed during childhood as idiopathic GHD 10 with multiple pituitary hormonal deficiencies (MPHD) and 33 with isolated GHD ([sGHD]). In a prospective study, GH secretion was re-assessed after interruption of GH treatment given for 1 year in 18 children with idiopathic GHD (2 MPHD, 16 IsGHD). GH secretion was evaluated by glucagon or insulin stimulation tests. Results: In the retrospective study, all the 10 patients with MPHD and 64% of the 33 patients with IsGHD were still deficient at re-evaluation using the paediatric criteria to define GHD (GH peak < 10 ng/ml at provocative test). The proportion of persisting deficiency was greater in patients with complete IsGHD (86%, 12/14 patients) than in patients with partial IsGHD (47%, 9/19 patients). With the criteria proposed in adulthood (GH peak <3 ng/ml), all the 10 patients with MPHD were still considered to be deficient. In contrast, only 15% (5/33 patients) with IsGHD had a maximal GH value < 3 ng/ml (36% of the 14 patients with complete IsGHD and none of the 19 patients with partial IsGHD). In the prospective study, after interruption of GH therapy given for 1 year, the 2 patients with MPHD were still GHD at re-evaluation and they resumed GH treatment. Among the 16 patients with IsGHD, 13 (81%) were still deficient (peak response < 10 ng/ml) after 1 year. Two of the 3 patients in whom GHD was not confirmed at retesting after 1 year GH showed again a deficient response at second retesting. Conclusions: Although many patients diagnosed with IsGHD during childhood have a normalized GH secretory capacity when retested during adulthood, early retesting after interruption of GH treatment given for 1 year during childhood does not enable to determine if GH therapy has to be discontinued before cessation of growth. Copyright (C) 2003 S. Karger AG, Basel. [less ▲]

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See detailTIMP-2 and PAI-1 mRNA levels are lower in aneurysmal as compared to athero-occlusive abdominal aortas.
Defawe, Olivier D; Colige, Alain ULg; Lambert, Charles ULg et al

in Cardiovascular Research (2003), 60(1), 205-13

OBJECTIVE: Significant alterations of the vascular wall occurs in abdominal aortic aneurysm (AAA) and atherosclerotic occlusive disease (AOD) that ultimately may lead to either vascular rupture or ... [more ▼]

OBJECTIVE: Significant alterations of the vascular wall occurs in abdominal aortic aneurysm (AAA) and atherosclerotic occlusive disease (AOD) that ultimately may lead to either vascular rupture or obstruction. These modifications have been ascribed to one or a group of proteases, their inhibitors or to the matrix macromolecules involved in the repair process without considering the extent of the observed variations. METHODS: The mRNA steady-state level of a large spectrum of proteolytic enzymes (matrix metalloproteinases: MMP-1, -2, -3, -8, -9, -11, -12, -13, -14; urokinase plasminogen activator: u-PA), their physiological inhibitors (tissue inhibitors of MMPs: TIMP-1, -2, -3; plasminogen activator inhibitor: PAI-1) and that of structural matrix proteins (collagens type I and III, decorin, elastin, fibrillins 1 and 2) was determined by RT-PCR made quantitative by using a synthetic RNA as internal standard in each reaction mixture. The profile of expression was evaluated in AAA (n=7) and AOD (n=5) and compared to non-diseased abdominal (CAA, n=7) and thoracic aorta (CTA, n=5). RESULTS: The MMPs -8, -9, -12 and -13 mostly associated with inflammatory cells were not or barely detected in CAA and CTA while they were largely and similarly expressed in AAA and AOD. Expression of protease inhibitors or structural proteins were only slightly increased in both pathological conditions with the exception of elastin which was reduced. The main significant difference between AAA and AOD was a lower expression of TIMP-2 and PAI-1 in the aneurysmal lesions. CONCLUSIONS: The remodeling of the aortic wall in AAA and AOD involves gene activation of a large and similar spectrum of proteolytic enzymes while the expression of two physiological inhibitors, TIMP-2 and PAI-1, is significantly lower in AAA compared to AOD. The repair process in the aneurysmal disease seems similar to that of the occlusive disease. [less ▲]

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See detailVascular endothelial growth factor expression correlates with matrix metalloproteinases MT1-MMP, MMP-2 and MMP-9 in human glioblastomas.
Munaut, Carine ULg; Noël, Agnès ULg; Hougrand, Olivier ULg et al

in International Journal of Cancer = Journal International du Cancer (2003), 106(6), 848-55

Vascular endothelial growth factor (VEGF) is the major endothelial mitogen in central nervous system neoplasms and it is expressed in 64-95% of glioblastomas (GBMs). Tumour cells are the main source of ... [more ▼]

Vascular endothelial growth factor (VEGF) is the major endothelial mitogen in central nervous system neoplasms and it is expressed in 64-95% of glioblastomas (GBMs). Tumour cells are the main source of VEGF in GBMs whereas VEGF receptors (VEGFR-1, its soluble form sVEGFR-1, VEGFR-2 and neuropilin-1) are expressed predominantly by endothelial cells. Infiltrating tumour cells and newly-formed capillaries progress through the extracellular matrix by local proteolysis involving matrix metalloproteinases (MMPs). Recent studies have shown that VEGF expression and bioavailability can be modulated by MMPs. We reported previously that the expression of MT1-MMP in human breast cancer cells was associated with an enhanced VEGF expression. We used quantitative RT-PCR, Western blot, gelatin zymography and immunohistochemistry to study the expression of VEGF, VEGFR-1, VEGFR-2, sVEGFR-1, neuropilin-1, MT1-MMP, MMP-2, MMP-9 and TIMP-2 in 20 human GBMs and 5 normal brains. The expression of these MMPs was markedly increased in most GBMs with excellent correlation between mRNA and protein levels; activated forms of MMP-2 and MMP-9 were present in 8/18 and 7/18 of GBMs. A majority of GBMs (17/20) also expressed high levels of VEGF, as previously reported, with strong correlation between VEGF and MT1-MMP gene expression levels, and double immunostaining showed that VEGF and MT1-MMP peptides co-localize in tumour and endothelial cells. Our results suggest that the interplay between metalloproteinases and VEGF previously described in experimental tumours may also be operative in human GBMs. Because of its dual ability to activate MMP-2 and to up-regulate VEGF, MT1-MMP might be of central importance in the growth of GBMs and represent an interesting target for anti-cancer treatments. [less ▲]

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See detailHematopoietic cell transplantation: five decades of progress.
Baron, Frédéric ULg; Storb, Rainer; Little, Marie-Terese

in Archives of Medical Research (2003), 34(6), 528-44

During the past 50 years, the role of allogeneic hematopoietic cell transplantation (HCT) has changed from a desperate therapeutic maneuver plagued by apparently insurmountable complications to a curative ... [more ▼]

During the past 50 years, the role of allogeneic hematopoietic cell transplantation (HCT) has changed from a desperate therapeutic maneuver plagued by apparently insurmountable complications to a curative treatment modality for thousands of patients with hematologic diseases. Now, cure rates following human leukocyte antigen (HLA) allogeneic HCT with matched siblings exceed 85% for some otherwise lethal diseases, such as chronic myeloid leukemia, aplastic anemia, or thalassemia. In addition, the recent development of non-myeloablative conditioning and stem cell transplantation has opened the way to include elderly patients with a wide variety of hematologic malignancies. Further progress in adoptive transfer of T cell populations with relative tumor specificity would make the transplant procedure more effective and would extend the use of allogeneic HCT for treatment of non-hematopoietic malignancies. [less ▲]

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See detailPreparation of nanosized barium zirconate powder by thermal decomposition of urea in an aqueous solution containing barium and zirconium, and by calcination of the precipitate
Boschini, Frédéric ULg; Robertz, B.; Rulmont, André ULg et al

in Journal of the European Ceramic Society (2003), 23(16), 3035-3042

The synthesis of barium zirconate was initiated by urea induced homogeneous precipitation followed by a "low temperature" thermal treatment. The kinetic of the reaction and the optimum urea/cation ratio ... [more ▼]

The synthesis of barium zirconate was initiated by urea induced homogeneous precipitation followed by a "low temperature" thermal treatment. The kinetic of the reaction and the optimum urea/cation ratio have been determined by means of X-ray diffraction and Inductive Coupled Plasma analyses. It has been demonstrated that an amorphous zirconium hydrated oxide starts to precipitate followed by the precipitation of barium carbonate. A calcination at 1200 degreesC during 2 h gives rise to the formation of a pure barium zirconate phase. Microstructural characterisations have been performed in order to evaluate the sintering behaviour. Dilatometric measurements, coupled with scanning electron microscopy analyses clearly indicate that barium carbonate decomposition process leads to the formation of internal porosity which severely limits the density of the material, even if a sintering was performed at 1500 degreesC. A careful control of the heating profile seems to be necessary in order to produce dense materials. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

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See detailPatterns of molecular and morphological variation in Leucobryum albidum, L. Glaucum, and L-juniperoideum (Bryopsida)
Vanderpoorten, Alain ULg; Boles, S.; Shaw, A. J.

in Systematic Botany (2003), 28(4, OCT-DEC), 651-656

Restriction digest patterns from 18S-26S nuclear ribosomal DNA internal transcribed spacers (ITS) were employed to investigate delineation between the morphologically similar moss species Leucobryum ... [more ▼]

Restriction digest patterns from 18S-26S nuclear ribosomal DNA internal transcribed spacers (ITS) were employed to investigate delineation between the morphologically similar moss species Leucobryum glaucum, L. juniperoideum, and L. albidum. Discriminant analysis allowed assignment of specimens to haplotypes based on their morphological features and supported the recognition of L. glaucum and L. albidum. In contrast, L. albidum and L. juniperoideum both corresponded to the same haplotype. Many populations could be readily assigned to either L. glaucum or L. albidum by their morphological features. However, morphological variation between these two species was continuous and one of the ITS haplotypes could not be unambiguously characterized by its morphology. Genetically and morphologically identifiable specimens of L. albidum were sampled in Europe and North America, in contrast to the traditional interpretation of L. albidum as a North American endemic. Although L. albidum seems to have a more southern-Atlantic distribution pattern than L. glaucum, the two species occupy broadly overlapping geographic ranges and were sometimes found intermixed. [less ▲]

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See detailVan Biervliet Jules
Richelle, Marc ULg

in Nouvelle biographie nationale. Vol. 7 (2003)

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See detailProsthetic vascular infection complicated or not by aortoenteric fistula: comparison of treatment with and without cryopreserved allograft (homograft).
Lavigne, Jean-Paul ULg; Postal, Alain ULg; Kolh, Philippe ULg et al

in European Journal of Vascular and Endovascular Surgery (2003), 25(5), 416-23

OBJECTIVES: in patients with vascular prosthesis infection, to compare surgical outcome and long-term results of cryopreserved allograft implantations to conventional surgery. DESIGN: retrospective study ... [more ▼]

OBJECTIVES: in patients with vascular prosthesis infection, to compare surgical outcome and long-term results of cryopreserved allograft implantations to conventional surgery. DESIGN: retrospective study. MATERIAL AND METHODS: two asynchronous series of 44 [series I: 1980-1994; 8 patients with aortoenteric fistula (AEF)] and 22 (series II: 1994-1997; 4 patients with AEF) patients were treated for prosthesis infection. All patients had prosthesis excision. In series I, there were 4 in situ reparations, 26 extra-anatomic bypass, 13 excision only, and one death at laparotomy. In series II, in situ cryopreserved allografts were implanted in all patients. RESULTS: operative mortality was 16% in series I and 13.6% in series II. For AEF patients, mortality was 37% in series I and 50% in series II. Among hospital survivors, infection-related late mortality was 13.5% in series I and 5% in series II. For AEF patients, late mortality was 20% in series I and 50% in series II. Incidence of reoperations was 54% in series I and 10.5% in series II (p<0.01). Hospital stay was 47.2+/-26.4 days in series I and 16.6+/-11.5 days in series II (p<0.001). CONCLUSIONS: compared to conventional treatment, incidence of reoperations and length of hospital stay are significantly decreased after cryopreserved allograft implantation. However, closure of aortic stump and extra-anatomic bypass gives better results for patients with AEF. [less ▲]

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See detailSample size reassessment for continuous data in clinical trials
Donneau, Anne-Françoise ULg

Master's dissertation (2003)

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