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See detailLa prescription médicamenteuse chez la personne âgée: que devons-nous savoir?
Wotquenne, Pol ULg; Petermans, Jean ULg; Scheen, André ULg

in Revue Médicale Suisse (2006), 2(76), 1878-801882-3

Because of the increasing longevity of the population, a growing number of very old people are exposed to medications. Drug therapy in this population is difficult because of our lack of knowledge. The ... [more ▼]

Because of the increasing longevity of the population, a growing number of very old people are exposed to medications. Drug therapy in this population is difficult because of our lack of knowledge. The number of drugs administered is generally high and the prescription is often inappropriate. Changes in body composition, malnutrition and renal failure can cause drug accumulation and toxicity. However, hepatic metabolism via cytochrome P450 does not seem to be markedly influenced by oldness. Iatrogenic pathology is frequent in the elderly and may lead to hospitalisation and reduction in quality of life. Specific education of the medical care team should be promoted in order to tackle this important problem of public health. [less ▲]

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See detailRegulation of vimentin by SIP1 in human epithelial breast tumor cells
Bindels, Sandrine ULg; Mestdagt, Mélanie ULg; Van de Walle, C. et al

in Oncogene (2006), 25(36), 4975-4985

The expression of Smad interacting protein-1 (SIP1; ZEB2) and the de novo expression of vimentin are frequently involved in epithelial-to-mesenchymal transitions (EMTs) under both normal and pathological ... [more ▼]

The expression of Smad interacting protein-1 (SIP1; ZEB2) and the de novo expression of vimentin are frequently involved in epithelial-to-mesenchymal transitions (EMTs) under both normal and pathological conditions. In the present study, we investigated the potential role of SIP1 in the regulation of vimentin during the EMT associated with breast tumor cell migration and invasion. Examining several breast tumor cell lines displaying various degrees of invasiveness, we found SIP1 and vimentin expression only in invasive cell lines. Also, using a model of cell migration with human mammary MCF10A cells, we showed that SIP1 is induced specifically in vimentin-positive migratory cells. Furthermore, transfection of SIP1 cDNA in MCF10A cells increased their vimentin expression both at the mRNA and protein levels and enhanced their migratory abilities in Boyden Chamber assays. Inversely, inhibition of SIP1 expression by RNAi strategies in BT-549 cells and MCF10A cells decreased vimentin expression. We also showed that SIP1 transfection did not activate the TOP-FLASH reporter system, suggesting that the beta-catenin/TCF pathway is not implicated in the regulation of vimentin by SIP1. Our results therefore implicate SIP1 in the regulation of vimentin observed in the EMT associated with breast tumor cell migration, a pathway that may contribute to the metastatic progression of breast cancer. [less ▲]

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See detailBulletin agrométéorologique - Juillet 2006
Tychon, Bernard ULg; Ozer, Pierre ULg; De Longueville, Florence ULg et al

in Bulletin agrométéorologique (2006), 5(4), 1-6

Le mois de juillet fut exceptionnellement chaud et sec jusqu’à la dernière semaine de juillet. Cette période sèche, dans la prolongation de celle du mois de juin, a pu entraîner des chutes de rendements ... [more ▼]

Le mois de juillet fut exceptionnellement chaud et sec jusqu’à la dernière semaine de juillet. Cette période sèche, dans la prolongation de celle du mois de juin, a pu entraîner des chutes de rendements de certaines cultures en phases sensibles en particulier là où la nature des sols n’a pas pu répondre aux besoins en eau des cultures. La situation des cultures reste cependant globalement favorable, laissant entrevoir des rendements généralement supérieurs à la moyenne des cinq années précédentes. [less ▲]

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See detailSound production mechanism in carapid fish: first example with a slow sonic muscle
Parmentier, Eric ULg; Lagardere, J. P.; Braquegnier, J. B. et al

in Journal of Experimental Biology (2006), 209(15), 2952-2960

Fish sonic swimbladder muscles are the fastest muscles in vertebrates and have fibers with numerous biochemical and structural adaptations for speed. Carapid fishes produce sounds with a complex ... [more ▼]

Fish sonic swimbladder muscles are the fastest muscles in vertebrates and have fibers with numerous biochemical and structural adaptations for speed. Carapid fishes produce sounds with a complex swimbladder mechanism, including skeletal components and extrinsic sonic muscle fibers with an exceptional helical myofibrillar structure. To study this system we stimulated the sonic muscles, described their insertion and action and generated sounds by slowly pulling the sonic muscles. We find the sonic muscles contract slowly, pulling the anterior bladder and thereby stretching a thin fenestra. Sound is generated when the tension trips a release system that causes the fenestra to snap back to its resting position. The sound frequency does not correspond to the calculated resonant frequency of the bladder, and we hypothesize that it is determined by the snapping fenestra interacting with an overlying bony swimbladder plate. To our knowledge this tension release mechanism is unique in animal sound generation. [less ▲]

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See detailMapping and polymorphism of bovine ghreline gene
Colinet, Frédéric ULg; Eggen, André; Halleux, Caroline et al

Poster (2006, August)

Bovine ghrelin, a 27-amino-acid peptide has been identified in bovine oxyntic glands of the abomasum. It is an endogenous growth hormone secretagogue. Total mRNA was extracted from abomasum and complete ... [more ▼]

Bovine ghrelin, a 27-amino-acid peptide has been identified in bovine oxyntic glands of the abomasum. It is an endogenous growth hormone secretagogue. Total mRNA was extracted from abomasum and complete ghrelin mRNA was sequenced by rapid amplification of cDNA ends. The gene contains five exons and four introns with a short noncoding first exon of 17 bp similar to mouse and human ghrelin gene. Using a radiation hybrid panel, the gene was mapped to chromosome 22 near microsatellite markers UWCA49, BM4102, BMS1932, BM2613 and URB035 with good LOD Score. Some studies detected different QTLs near these markers like for milk fat percent, milk protein percent and somatic cell score. So, it would be interesting to study the polymorphism on the bovine ghrelin gene. Screening for polymorphisms in the five exons and the introns II and IV on ten Belgian Blue bulls, ten Holsteins bulls and ten Limousin bulls revealed a total of three single nucleotide polymorphisms. In order to evaluate if ghrelin could be involved in genetic variation for milk fat percent, milk protein percent and somatic cell score an association study between SNPs on ghrelin gene and these traits could be performed in a major cattle population. [less ▲]

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See detailWithin and across breeds differences in fatty acids profiles of milk and milk fat in dairy cows
Soyeurt, Hélène ULg; Dardenne, Pierre; Mayeres, Patrick et al

Poster (2006, August)

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See detailMasses of [70, l(+)] baryons in the 1/N-c expansion
Matagne, Nicolas; Stancu, Floarea ULg

in Physical Review D (2006), 74(3), 034014

The masses of positive parity [70,0(+)] and [70,2(+)] nonstrange and strange baryons are calculated in the 1/N-c expansion. The approach is based on the separation of a system of N-c quarks into an ... [more ▼]

The masses of positive parity [70,0(+)] and [70,2(+)] nonstrange and strange baryons are calculated in the 1/N-c expansion. The approach is based on the separation of a system of N-c quarks into an excited core and an excited quark. The previous work for two flavor baryons is now extended to include strange baryons, to first order in SU(3)-flavor breaking. We show that the extension to N-f=3 maintains the regularities previously observed in the behavior of the linear term in N-c, of the spin-spin and of the spin-orbit terms. In particular the contribution of the spin-dependent terms decrease with the excitation energy, the dominant term remaining the spin-spin term. [less ▲]

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See detailMapping and polymorphism of bovine ghreline gene
Colinet, Frédéric ULg; Eggen, André; Gengler, Nicolas ULg et al

in Proceedings of the 30th International Conference on Animal Genetics ISAG 2006 - Biodiversity, the future pass through preservation (2006, August)

Bovine ghrelin, a 27-amino-acid peptide has been identified in bovine oxyntic glands of the abomasum. It is an endogenous growth hormone secretagogue. Total mRNA was extracted from abomasum and complete ... [more ▼]

Bovine ghrelin, a 27-amino-acid peptide has been identified in bovine oxyntic glands of the abomasum. It is an endogenous growth hormone secretagogue. Total mRNA was extracted from abomasum and complete ghrelin mRNA was sequenced by rapid amplification of cDNA ends. The gene contains five exons and four introns with a short noncoding first exon of 17 bp similar to mouse and human ghrelin gene. Using a radiation hybrid panel, the gene was mapped to chromosome 22 near microsatellite markers UWCA49, BM4102, BMS1932, BM2613 and URB035 with good LOD Score. Some studies detected different QTLs near these markers like for milk fat percent, milk protein percent and somatic cell score. So, it would be interesting to study the polymorphism on the bovine ghrelin gene. Screening for polymorphisms in the five exons and the introns II and IV on ten Belgian Blue bulls, ten Holsteins bulls and ten Limousin bulls revealed a total of three single nucleotide polymorphisms. In order to evaluate if ghrelin could be involved in genetic variation for milk fat percent, milk protein percent and somatic cell score an association study between SNPs on ghrelin gene and these traits could be performed in a major cattle population. [less ▲]

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See detailAn efficient implicit approach for the thermomechanical behavior of materials submitted to high strain rates
Jeunechamps, Pierre-Paul ULg; Ponthot, Jean-Philippe ULg

in Journal de Physique IV (2006), 134

In the present paper, three solutions are proposed to simulate fast phenomena with finite element method at best. At first, material constitutive laws of Johnson-Cook and Zerilli-Armstrong types are ... [more ▼]

In the present paper, three solutions are proposed to simulate fast phenomena with finite element method at best. At first, material constitutive laws of Johnson-Cook and Zerilli-Armstrong types are implemented. These well-known laws are efficient for the description of material behavior at high velocities, especially for material used in automotive or aeronautics industry. The second contribution of this paper is the coupling of an implicit Chung-Hulbert algorithm taking into account the inertial effects with a staggered scheme for solving the thermal problem. The last input of this paper is the use of EAS (Enhanced Assumed Strain) finite elements to better capture complex strain modes, especially bending that is not accurately evaluated with classical finite elements. These EAS finite elements are used in the scope of thermomechanical dynamic phenomena implemented in a modular C++ environment at the University of Liege in the home made software METAFOR. [less ▲]

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See detailAbstract numeration systems : a survey.
Rigo, Michel ULg

Conference (2006, August)

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See detailOsteoarthritis, magnetic resonance imaging, and biochemical markers: a one year prospective study
Bruyère, Olivier ULg; Collette, Julien ULg; Kothari, M. et al

in Annals of the Rheumatic Diseases (2006), 65(8), 1050-1054

Objective: To investigate the relation between biochemical markers of bone, cartilage, and synovial remodelling and the structural progression of knee osteoarthritis. Methods: 62 patients of both sexes ... [more ▼]

Objective: To investigate the relation between biochemical markers of bone, cartilage, and synovial remodelling and the structural progression of knee osteoarthritis. Methods: 62 patients of both sexes with knee osteoarthritis were followed prospectively for one year. From magnetic resonance imaging ( MRI), done at baseline and after one year, the volume and thickness of cartilage of the femur, the medial tibia, and the lateral tibia were assessed. A whole organ magnetic resonance imaging score ( WORMS) of the knee was calculated for each patient at baseline and at the one year visits. This score consists in a validated, semiquantitative scoring system for whole organ assessment of the knee in osteoarthritis using MRI. Biochemical markers ( serum hyaluronic acid, osteocalcin, cartilage glycoprotein 39 ( YKL-40), cartilage oligomeric matrix protein ( COMP), and C-telopeptide of type I collagen ( CTX-I), and urine C-telopeptide of type II collagen ( CTX-II)) were measured at baseline and after three months. Results: Baseline markers were not correlated with one year changes observed in cartilage volume and thickness. However, an increase in CTX-II after three months was significantly correlated with a one year decrease in mean thickness of medial tibial and lateral tibial cartilage. Patients in the highest quartile of three month changes in CTX-II experienced a mean loss of 0.07 ( 0.08) mm of their medial thickness, compared with a mean increase of 0.05 ( 0.19) mm for patients in the lowest quartile ( p = 0.04) Multiple regression analysis showed that high baseline levels of hyaluronic acid are predictive of a worsening in WORMS ( p = 0.004). Conclusions: These results suggest that a single measurement of serum hyaluronic acid or short term changes in urine CTX-II could identify patients at greatest risk of progression of osteoarthritis. [less ▲]

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See detailAn XMM-Newton view of the young open cluster NGC 6231 - I. The catalogue
Sana, H.; Gosset, Eric ULg; Rauw, Grégor ULg et al

in Astronomy and Astrophysics (2006), 454(3), 1047-115

This paper is the first of a series dedicated to the X-ray properties of the young open cluster NGC 6231. Our data set relies on an XMM-Newton campaign of a nominal duration of 180 ks and reveals that NGC ... [more ▼]

This paper is the first of a series dedicated to the X-ray properties of the young open cluster NGC 6231. Our data set relies on an XMM-Newton campaign of a nominal duration of 180 ks and reveals that NGC 6231 is very rich in the X-ray domain too. Indeed, 610 X-ray sources are detected in the present field of view, centered on the cluster core. The limiting sensitivity of our survey is approximately 6 x 10(-15) erg cm(-2) s(-1) but clearly depends on the location in the field of view and on the source spectrum. Using different existing catalogues, over 85% of the X-ray sources could be associated with at least one optical and/or infrared counterpart within a limited cross-correlation radius of 3" at maximum. The surface density distribution of the X-ray sources presents a slight N-S elongation. Once corrected for the spatial sensitivity variation of the EPIC instruments, the radial profile of the source surface density is well described by a King profile with a central density of about 8 sources per arcmin(2) and a core radius close to 3.1 arcmin. The distribution of the X-ray sources seems closely related to the optical source distribution. The expected number of foreground and background sources should represent about 9% of the detected sources, thus strongly suggesting that most of the observed X-ray emitters are physically belonging to NGC 6231. Finally, beside a few bright but soft objects - corresponding to the early-type stars of the cluster - most of the sources are relatively faint (similar to 5 x 10(-15) erg cm(-2) s(-1)) with an energy distribution peaked around 1.0-2.0 keV. [less ▲]

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See detailRimonabant improves multiple cardiometabolic risk factors in diabetic and non-diabetic overweight/obese patients: data from RIO-diabetes, RIO-Europe, RIO-North America and RIO-Lipids
Scheen, André ULg; Despres, J. P.; Pi-Sunyer, F. X. et al

in European Heart Journal (2006, August), 27(Suppl. 1), 441

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See detailVariations in processing resources and resistance to false memories in younger and older adults
Dehon, Hedwige ULg

in Memory (2006), 14(6), 692-711

The influence of available processing resources on the resistance to false memories (FMs) for lists of semantically related items associated with a non-presented critical lure was examined in younger and ... [more ▼]

The influence of available processing resources on the resistance to false memories (FMs) for lists of semantically related items associated with a non-presented critical lure was examined in younger and older adults. Reducing the available resources at encoding in younger adults (Experiments 1 and 2) led to a performance similar to that of older adults (i.e., higher rates of FMs in addition to reduced rates of correct recall). However, increasing the available resources (Experiments 2 and 3) led to improvements in the rates of correct recall in both age groups and decreased the probability of FMs in younger adults, although warnings had to be added in older adults to obtain similar effects on FMs. Parallel influences on a post-recall test asking participants to report items that they had thought of but did not recall were also found. The influence of available cognitive resources for memory accuracy is also discussed with respect to activation-monitoring (e.g., McDermott [less ▲]

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See detailMultiple Description Coding versus Transport Layer FEC for Resilient Video Transmission
Soldani, Cyril ULg; Verdicchio, Fabio; Leduc, Guy ULg et al

(2006, August)

Video content delivery is a challenging task due to its large bandwidth requirements and its sensitivity to transmission errors. In this context, simultaneously providing scalability and resilience ... [more ▼]

Video content delivery is a challenging task due to its large bandwidth requirements and its sensitivity to transmission errors. In this context, simultaneously providing scalability and resilience against transmission errors is of paramount importance. Layered video coding coupled with multicast video transmission employing no feedback provides the required scalability features and reduces the network burden. However, it is not easy to provide reliability in such environments. This is crucial to mobile users as error rates on wireless links can be high. To compensate for transmission errors, redundancy must be added to the video content. This can be added at the application layer by the employed video coding system, or can be added transparently by the transport layer. In this paper, we compare the performance obtained with a scalable wavelet-based video codec that adds redundancy using multiple description coding with the equivalent system adding redundancy at the transport level, using forward error correction. [less ▲]

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See detailEXPERIENCE GAINED BY THE APPLICATION OF A REAL-TIME VOLTAGE SECURITY ASSESSMENT METHOD AT THE HELLENIC TRANSMISSION SYSTEM OPERATOR
Christoforidis, George; Kabouris, John; Vournas, Costas et al

(2006, August)

Voltage instability is widely recognized as a significant threat of power system blackout. As far as real-time operation is concerned, there is a need for appropriate tools to identify dangerous ... [more ▼]

Voltage instability is widely recognized as a significant threat of power system blackout. As far as real-time operation is concerned, there is a need for appropriate tools to identify dangerous contingencies and assess security margins. The Hellenic Interconnected System presents a structural geographical imbalance between the main generation site and the main load center. This imbalance leads to bulk power transfers over long distances leading to voltage stability problems in areas of the southern system during heavy load conditions. In order to improve the operational practices, a realtime Voltage Security Assessment (VSA) tool has been installed at the National Control Center of the Hellenic Transmission System Operator (HTSO). The scope of VSA is the analysis of the impact of significant contingencies and the determination of security margins in terms of power transfers or power consumption in load areas. The computations performed within the VSA tool are based on a Quasi-Steady-State simulation, a fast time-domain method well suited to the analysis of long-term voltage stability phenomena. VSA is performed on the current system state, provided by the Energy Management System (EMS) state estimator. The VSA application incorporates functions for filtering the contingencies, determining secure operation limits, and deriving post-contingency PV curves for the identified dangerous contingencies. This paper is a description of the experience and the added value gained by the application of the real-time VSA, in parallel with the existing EMS, at the control center of HTSO. [less ▲]

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See detailPALETTE: Grid of Analysis Supporting the Participative Design Methodology
Pironet, Fabienne ULg; Charlier, Bernadette; Daele, Amaury et al

Report (2006)

This deliverable presents the participatory design methodology of the PALETTE project and some first results of the implementation of this process. Some principles of the Actor Network Theory and of the ... [more ▼]

This deliverable presents the participatory design methodology of the PALETTE project and some first results of the implementation of this process. Some principles of the Actor Network Theory and of the Agile Methodology are embedded in the different stages of this methodology whose twelve stages (described in details in the last section) will be the basis of the participative development of services and scenarios of use. The first two stages of the process, establishing the collaboration with the CoPs and modelling their activities, have been implemented. Concrete results are available, i.e. procedures implemented to enrol the partners, methodological tools to gather and analyse the data from the CoPs. Some information has been communicated to partners of WPs 2, 3, 4 and 5 that needed it to progress in the development of their work. This process is not ended; it is iterative and will be refined all along the project. [less ▲]

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See detailLipase production by Yarrowia lipolytica: study of the effects of operating conditions by factorial design of experiments
Lopes, M.; Gomes, I.; Araújo, C. et al

in European Symposium on Biochemical Engineering Science : book of abstracts”. [S.l. : s.n. 2006] (2006, August)

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