Publications ORBi OA
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See detailDoes the Direction of Ductal Blood Flow Affect Regional Circulatory Hemodynamics in Duct Dependent Congenital Heart Disease?
Campbell, Morag; Rigo, Vincent ULg; Robertson, Murray

in Pediatric Research (2003, April), 53(4 Part 2/2), 471

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See detailAlimentation et cancer
Castronovo, Vincenzo ULg

in Revue Médicale de Liège (2003), 58(4), 231-9

The role of a qualitatively and quantitatively altered nutrition for the development of cancer in human is largely recognized. While the human life expectancy is continuously expanding and the World ... [more ▼]

The role of a qualitatively and quantitatively altered nutrition for the development of cancer in human is largely recognized. While the human life expectancy is continuously expanding and the World Health Organization is predicting a dramatic rise in the number of patients that will get cancer and die from it in the next decades, it is useful to attempt to understand the real impact of nutrition at the level of the oncogenesis mechanisms. Oxidative stress, methylation deficit and imbalance in the ratio of omega-3 and omega-6 fatty acids represents situations directly linked to nutrition and which contribute to an increased risk for cancer development. The understanding of the mechanisms by which nutrition affects these processes should better stimulate health professionals to consider with more attention what their patients are eating. [less ▲]

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See detailGPs working in solo practice : obstacles and motivations for working in a group ? A qualitative study
Feron, Jean-Marc; Cerexhe, F.; Pestiaux, Dominique et al

in BMC Family Practice (2003), 20(2), 167-172

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See detailEffects of a progestogen on normal human breast epithelial cell apoptosis in vitro and in vivo
Desreux, Joëlle ULg; Kebers, F.; Noël, Agnès ULg et al

in Breast (Edinburgh, Scotland ) (2003), 12(2), 142-149

Many investigators have reported cyclic proliferation of normal human breast epithelial cells. A delicate balance between proliferation and apoptosis (programmed cell death) ensures breast homeostasis ... [more ▼]

Many investigators have reported cyclic proliferation of normal human breast epithelial cells. A delicate balance between proliferation and apoptosis (programmed cell death) ensures breast homeostasis. Both the follicular and luteal phases of the menstrual cycle are characterized by proliferation, whereas apoptosis occurs only at the end of the latter phase. In this study, we observed that the withdrawal of a synthetic progestin (nomegestrol acetate or NOMAC), but not continuous treatment with it, induced apoptosis of normal human breast epithelial cells in vitro and in women who applied NOMAC gel to their breasts. Furthermore, this apoptotic response was specific to normal breast cells, since withdrawal of NOMAC did not induce apoptosis of tumoral T47D cells in vitro or of fibroadenoma cells in women. These observations open up new perspectives in the prevention of hyperplasia and breast cancer. (C) 2003 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailImpact of the joint space width measurement method on the design of knee osteoarthritis studies.
Bruyère, Olivier ULg; Henrotin, Yves ULg; Honore, Aline et al

in Aging Clinical & Experimental Research (2003), 15(2), 136-41

BACKGROUND AND AIMS: Recent guidelines recommend measurement of articular loss over several years, determined by conventional X-rays, as the principal outcome measure in clinical trials of potential ... [more ▼]

BACKGROUND AND AIMS: Recent guidelines recommend measurement of articular loss over several years, determined by conventional X-rays, as the principal outcome measure in clinical trials of potential structure-modifying drugs in osteoarthritis (OA). The aim of this study was to assess the impact of the joint space width measurement method on sample size calculation in knee OA studies. METHODS: Standard knee X-rays were taken in 212 patients with knee OA at baseline and after 3 years of follow-up. Mean joint space width (JSW) was measured with an in-house computer-assisted method. Minimum JSW, measured with a graduated magnifying lens, was taken as external standard. After calculation of the intra- and inter-observer reproducibility of the JSW, sensitivity to change was assessed using the standardized response mean (SRM). The number of patients needed to identify a mean significant difference of 0.5 mm in joint space narrowing between the placebo and the treated group, after 3 years of follow-up, was then calculated. RESULTS: JSW measured with the computer-assisted technique showed better intra- and inter-observer reproducibility than when using the magnifying lens. JSW values measured with our computer-assisted method were significantly correlated with JSW values obtained using the magnifying lens (r=0.87, p<0.001). The SRM were 0.44 and 0.40 for the computer-assisted method and magnifying lens, respectively. The number of patients needed was 131 per group using the computer-assisted method, and 104 using the magnifying lens. CONCLUSIONS: Our method of measurement of JSW may be of potential use in longitudinal studies evaluating the effect of structure-modifying drugs in OA, due to its high level of precision and efficiency. However, although sensitivity to change is markedly better with the digitized method compared with the graduated magnifying lens, we recommend the measurement of mean and minimum JSW in structure-modifying OA trials. [less ▲]

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See detailModernisation de l’interface citoyen - fonction publique: vers une intégration réfléchie des TIC
Lisein, Olivier ULg

in Pyramides (2003), 7(Printemps), 135-147

Périodique scientifique - Le secteur public connaît, ces dernières années, une profonde et sérieuse remise en question. Nombreux sont ainsi les états où une politique générale de modernisation de la ... [more ▼]

Périodique scientifique - Le secteur public connaît, ces dernières années, une profonde et sérieuse remise en question. Nombreux sont ainsi les états où une politique générale de modernisation de la fonction publique est, ou va être, instaurée. Au centre des préoccupations, le citoyen y bénéficie d’une place de choix: il fait l’objet de nombreuses attentions et peut donc désormais s’attendre à davantage d’égards. Qualité du service et satisfaction de la population deviennent en effet des concepts clés de la fonction publique. Pour atteindre ces objectifs, c’est toute la conception des relations qu’entretiennent citoyen et secteur public qui est revue. Les technologies de l’information et de la communication (TIC) présentent, dans ce cadre, de nombreux atouts. L’interface citoyen - secteur public s’en trouve modernisé avec, comme objectif avoué, une proximité accrue avec la population pour une plus grande satisfaction de celle-ci. Si ce recours aux TIC offre d’indéniables opportunités - tant en termes d’innovation de services que dans la manière dont ceux-ci sont prestés -, il n’en soulève pas moins certaines questions, l’accès aux services étant, pour le citoyen, complètement revu. Sur base d’une analyse critique de la littérature et de l’étude d’un cas concret, notre contribution entend questionner l’implémentation et la gestion des TIC dans l’interface citoyen - fonction publique. [less ▲]

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See detailPrevention primaire et secondaire du cancer colorectal
Polus, Marc ULg; Piront, Patricia ULg; Jerusalem, Guy ULg et al

in Revue Médicale de Liège (2003), 58(4), 247-53

Colorectal cancer is really a public health problem. The authors review the literature about the environmental factors leading to colorectal cancer. Chemoprevention of colorectal cancer is also discussed ... [more ▼]

Colorectal cancer is really a public health problem. The authors review the literature about the environmental factors leading to colorectal cancer. Chemoprevention of colorectal cancer is also discussed, particularly by aspirin and non steroidal anti-inflammatory drugs. Development of specific cyclooxygenase-2 inhibitors constitutes a promising research's field. Secondary prevention by coloscopy and polypectomy must lead to a lower rate of colorectal cancer disease and improvement of mortality. [less ▲]

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See detailSound-producing mechanisms and recordings in Carapini species (Teleostei, Pisces)
Parmentier, Eric ULg; Vandewalle, Pierre ULg; Lagardere, Jean-Pierre

in Journal of Comparative Physiology A-Neuroethology Sensory Neural and Behavioral Physiology (2003), 189(4), 283-292

Carapus boraborensis, C. homei and Encheliophis gracilis are three species of Carapidae that display the ability to penetrate and reside in the holothurian Bohadschia argus. This study describes both the ... [more ▼]

Carapus boraborensis, C. homei and Encheliophis gracilis are three species of Carapidae that display the ability to penetrate and reside in the holothurian Bohadschia argus. This study describes both the particular morphology of the sound-producing structures and, for the first time, the sounds produced by each species. The study of the structures composing the sound-producing system seems to indicate that the action made by the primary sonic muscles (i.e. the pulling and releasing of the front of the swim bladder) might be responsible for the sound emissions of these three species by provoking a vibration of a thinner zone in front of the swim bladder (swimbladder fenestra). The sounds were only emitted and recorded when several individuals of the same species were inside the same sea cucumber. They were composed of serially repeated knocks and were heard as drum beats or drum rolls. Their specific differences were mainly defined as variations in the timing or grouping of the knocking sounds. The recordings of these sound productions demonstrate a vocal ability for the three species, linked with the presence of particular organs associated with sound production. Moreover, the ecological significance of the sounds and of the sound apparatus system is discussed. [less ▲]

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See detailThe wind of the B[e] supergiant Henize S22 viewed through a reflection nebula in DEM L106
Chu, You-Hua; Chen, Chang-Hui Rosie; Danforth, Charles et al

in Astronomical Journal (The) (2003), 125(4), 2098-2107

Narrowband HST WFPC2 images reveal a bow-shock-like halo around the H II region N30B toward the B[e] supergiant Hen S22 located within the larger DEM L106 nebula in the Large Magellanic Cloud. High ... [more ▼]

Narrowband HST WFPC2 images reveal a bow-shock-like halo around the H II region N30B toward the B[e] supergiant Hen S22 located within the larger DEM L106 nebula in the Large Magellanic Cloud. High-dispersion spectra of N30B show a narrow Halpha emission component from the ionized gas; the velocity variations indicate a gas flow of - 5 to - 10 km s(-1) in the vicinity of the H II regions, which is resultant from interactions with Hen S22's stellar wind and responsible for the bow-shock morphology. Spectra of N30B's halo show broad Halpha profiles extending over more than 1000 km s(-1), similar to that of Hen S22, indicating that the halo is a reflection nebula of Hen S22. Broadband morphologies of N30B's halo are also consistent with the reflection nebula interpretation. We use dust-scattering properties and the observed brightnesses of the reflection nebula and Hen S22 to constrain the reflection geometry. The reflected stellar Halpha emission and absorption vary across the reflection nebula as a result of viewing S22's anisotropic wind from different angles. This reflection nebula, together with the edge-on orientation of Hen S22's disk, provides an invaluable opportunity to study the disk and polar winds of a B[e] supergiant. [less ▲]

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See detailVLT observations of the highly ionized nebula around Brey2
Nazé, Yaël ULg; Rauw, Grégor ULg; Manfroid, Jean ULg et al

in Astronomy and Astrophysics (2003), 401(2), 13-16

We present the first high resolution He II lambda4686 images of the high excitation nebula around the WR star Brey2 in the LMC. This nebula presents a striking morphology: a small arc-like feature some 3 ... [more ▼]

We present the first high resolution He II lambda4686 images of the high excitation nebula around the WR star Brey2 in the LMC. This nebula presents a striking morphology: a small arc-like feature some 3.6 pc in radius is particularly prominent in the He II lambda4686 line. We further discover a previously unknown faint He II emission that extends over an area of 22 x 17 pc(2). An even fainter He II emission is apparently associated with the interstellar bubble blown by the progenitor of Brey2. The total He II flux corresponds to an ionizing flux of 4 x 10(47) photons s(-1). Halpha, [O III], and He I lambda5876 images and long-slit spectra are also examined in this letter, enabling us to investigate the detailed physical properties at various locations of the nebula. [less ▲]

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See detailStratégies de prévention et de surveillance de Salmonella dans la filière porcine : 1. guide de bonnes pratiques destiné aux fabricants d'aliments, aux éleveurs, engraisseurs, transporteurs, abattoirs et professionnels de la viande.
Degeye, J.-N.; Korsak Koulagenko, Nicolas ULg; Etienne, G. et al

Book published by Les éditions de l'Université de Liège (2003)

Ce guide s’inscrit dans le cadre d’un projet de recherche co-financé par le Ministère de l’Agriculture de la Région Wallonne et le Ministère fédéral des Classes Moyennes et de l’Agriculture et intitulé « ... [more ▼]

Ce guide s’inscrit dans le cadre d’un projet de recherche co-financé par le Ministère de l’Agriculture de la Région Wallonne et le Ministère fédéral des Classes Moyennes et de l’Agriculture et intitulé « Recherche d’une méthodologie pour la mise en place et la surveillance d’une filière intégrée de production de viande porcine Salmonella-free ». Ce projet, d’une durée de quatre ans, a débuté en février 1999. Il est destiné à sensibiliser les différents acteurs de la filière porcine sur les risques liés aux salmonelles aussi bien pour les animaux que pour les humains. Il met l’accent sur l’importance d’une bonne hygiène d’abattage et de transformation de la viande, mais aussi et surtout sur le respect des règles d’hygiène élémentaires relatives à l’élevage et à l’engraissement. L’objectif est, avant tout, de donner, aux différents maillons de la chaîne de production, des recommandations à suivre pour tendre vers une production de viande porcine indemne de salmonelles. Il s’agit donc de mesures propres à la lutte contre Salmonella dans la filière porcine, complétant les réglementations en vigueur. D’autre part, un second guide a été élaboré. Il traite des plans d’échantillonnage, des techniques de prélèvement des échantillons en exploitation et à l’abattoir, des méthodes de détection ainsi que des méthodes de caractérisation des souches de salmonelles. Il s’adresse donc davantage aux responsables des contrôles et aux laboratoires de surveillance. De ce fait, le présent guide se contente de citer les méthodes de surveillance propres à chaque étude en renvoyant au guide technique. [less ▲]

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See detailStratégies de prévention et de surveillance de Salmonella dans la filière porcine : 1. guide destiné aux laboratoires et aux personnes en charge des prélèvements.
Degeye, J.-N.; Korsak Koulagenko, Nicolas ULg; Etienne, G. et al

Book published by Les éditions de l'Université de Liège (2003)

Ce guide s’inscrit dans le cadre d’un projet de recherche co-financé par le Ministère de l’Agriculture de la Région Wallonne et le Ministère fédéral des Classes Moyennes et de l’Agriculture et intitulé « ... [more ▼]

Ce guide s’inscrit dans le cadre d’un projet de recherche co-financé par le Ministère de l’Agriculture de la Région Wallonne et le Ministère fédéral des Classes Moyennes et de l’Agriculture et intitulé « Recherche d’une méthodologie pour la mise en place et la surveillance d’une filière intégrée de production de viande porcine Salmonella-free ». Ce projet, d’une durée de quatre ans, a débuté en février 1999. Il est destiné à sensibiliser les différents acteurs de la filière porcine sur les risques liés aux salmonelles aussi bien pour les animaux que pour les humains. Il met l’accent sur l’importance d’une bonne hygiène d’abattage et de transformation de la viande, mais aussi et surtout sur le respect des règles d’hygiène élémentaires relatives à l’élevage et à l’engraissement. L’objectif est, avant tout, de donner, aux différents maillons de la chaîne de production, des recommandations à suivre pour tendre vers une production de viande porcine indemne de salmonelles. Il s’agit donc de mesures propres à la lutte contre Salmonella dans la filière porcine, complétant les réglementations en vigueur. D’autre part, un second guide a été élaboré. Il traite des plans d’échantillonnage, des techniques de prélèvement des échantillons en exploitation et à l’abattoir, des méthodes de détection ainsi que des méthodes de caractérisation des souches de salmonelles. Il s’adresse donc davantage aux responsables des contrôles et aux laboratoires de surveillance. De ce fait, le présent guide se contente de citer les méthodes de surveillance propres à chaque étude en renvoyant au guide technique. [less ▲]

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See detailSolving problems with contact in machining process simulation
Masset, Luc ULg; Debongnie, Jean-François ULg; Berger, Frederic

in Brucato, Valerio (Ed.) Proceedings of the 6th International ESAFORM Conference on Material Forming (2003, April)

At the 2001 Esaform conference, we have presented a simulation tool designed to predict form errors of part surfaces obtained by face milling and turning processes. The most relevant aspect of the ... [more ▼]

At the 2001 Esaform conference, we have presented a simulation tool designed to predict form errors of part surfaces obtained by face milling and turning processes. The most relevant aspect of the developed method is its ability to solve industrial cases with huge 3D finite element meshes in a very small time. Until recently, we were only considering pure linear problems. However, the simulation of several machining operations requires the introduction of contact. The present paper describes the numerical method developed to solve such non linear problems. [less ▲]

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See detailManufacturing of a circular notch hinge as guiding system by electrical discharge machining
Croquet, Vincent; Merken, Patrick; Delchambre, Alain et al

Poster (2003, April)

Presentation of the notch hinge as a guiding system. Its manufacturing by wire electro-discharge machining. Notch design parameters. Future work.

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See detailThe practice of transcranial doppler in neonates
Battisti, Oreste ULg

Learning material (2003)

this video shows how to realize a transcranial and transcutaneaous doppler study of main arteries in neonates

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See detailTowards a quality label for distance courses. The EMDEL experimentation.
Dupont, Chantal ULg; Poumay, Marianne ULg; Leclercq, Dieudonné ULg et al

in Valorising good products and experiences in eductional and vocational training for enlarged Europe (2003, April)

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See detailMice without uPA, tPA, or plasminogen genes are resistant to experimental choroidal neovascularization
Rakic, Jean-Marie ULg; Lambert, Vincent ULg; Munaut, Carine ULg et al

in Investigative Ophthalmology & Visual Science (2003), 44(4), 1732-1739

PURPOSE. To evaluate the presence and potential involvement of members of the plasminogen/plasminogen activator (Plg/PA) system in the exudative form of age-related macular degeneration (AMD). METHODS ... [more ▼]

PURPOSE. To evaluate the presence and potential involvement of members of the plasminogen/plasminogen activator (Plg/PA) system in the exudative form of age-related macular degeneration (AMD). METHODS. The expression of PA members mRNA was evaluated in human and experimental choroidal neovascularization (CNV) by RT-PCR. The presence and activity of PA was studied by immunofluorescence and in situ zymography. The influence of endogenous plasminogen (Plg), urokinase (uPA), tissue type plasminogen activator (tPA), and uPA receptor (uPAR) was explored in single-gene-deficient mice in a model of laser-induced CNV. RESULTS. Members of the Plg/PA system were present both in human and murine CNV. The absence of Pig, uPA, or tPA significantly decreased the development of experimental CNV compared with wild-type or uPAR-deficient mice. This effect could be attributable, partly to a modulation of matrix metalloproteinase activity, but also to an accumulation of fibrinogen-fibrin in the laser-induced wounds. CONCLUSIONS. Together with previous work done by the authors, this study indicates that choroidal neovascularization is extremely sensitive to the modulation of Plg/PA system activity. This may provide a new strategy for the treatment of exudative AMD. [less ▲]

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See detailUsing 1984 in social reasoning
Jacquemain, Marc ULg

Conference (2003, April)

The book "1984" from George Orwell is the locus classicus for what can be called "dystopia" : a dark vision of a possible future. The paper argues first that some charateristics of the Oceanian society of ... [more ▼]

The book "1984" from George Orwell is the locus classicus for what can be called "dystopia" : a dark vision of a possible future. The paper argues first that some charateristics of the Oceanian society of Orwell make it rather unsuited to represent a plausible future for today's societies. Then, the paper goes on proposing that the continuous success of the book may lie on a misunderstanding : people probably appreciate its particular "conspiracist" stance. The paper concludes proposing that if it is so difficult for sociology to discard straightforwadly conspiracy theories, it is probably because main epistemological efforts within recent sociology have converge to reintroduce intentionality within explanation and that the core of conspiracy theory is precisely an overestimation of intentionality in the explanation of the world. [less ▲]

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See detailEarly development of stricturing or penetrating pattern in Crohn's disease is influenced by disease location, number of flares, and smoking but not by NOD2/CARD15 genotype
Louis, Edouard ULg; Michel, V.; Hugot, J. P. et al

in Gut (2003), 52(4), 552-557

Background: Crohn's disease is a heterogeneous entity. Disease behaviour, characterised as structuring, penetrating, or non-stricturing non-penetrating, is a clinically important phenotype as it is ... [more ▼]

Background: Crohn's disease is a heterogeneous entity. Disease behaviour, characterised as structuring, penetrating, or non-stricturing non-penetrating, is a clinically important phenotype as it is associated with complications and need for surgery. It has recently been showed that the behaviour of Crohn's disease changes over the course of the disease. Aim: To assess the association between rapid development of a penetrating or stricturing pattern of Crohn's disease and demographic and clinical characteristics as well as NOD2/CARD15 genotype. Patients and methods: A total of 163 patients with a firm diagnosis of Crohn's disease and who had non-penetrating non-stricturing disease at diagnosis were studied. Various demographic and clinical characteristics as well as anitsaccharomyces cerevisiae antibody status and NOD2/CARD15 genotype were documented in these patients. These characteristics were compared in subgroups of patients according to evolution of disease behaviour five years after diagnosis. Results: Five years after diagnosis there were 110 (67.5%) patients with non-structuring non-penetrating disease, 18 (11%) with stricturing disease, and 35 (21.5%) with penetrating disease. In multivariate analysis, only disease location and number of flares per year were significantly discriminant between the three subgroups (p=0.0009 and 0.0001, respectively). Ileal location of the disease was associated with a stricturing pattern while a high number of flares was associated with a penetrating pattern. Active smoking was also associated with a penetrating pattern compared with a non-stricturing non-penetrating pattern only. Conclusions: Early development of stricturing or penetrating behaviour in Crohn's disease is influenced by disease location, clinical activity of the disease, and smoking habit, but not by NOD2/CARD15 genotype. [less ▲]

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