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See detailDevelopment of edumetrical indices for the analysis of the spectral quality of higher education standardized tests
Gilles, Jean-Luc ULg

in 11th Biennal Conference of the European Association for Research on Learning and Instruction - Multiple Perspectives on Effective Learning Enviroments - Abstracts (2005)

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See detailGeochemistry of cumulates from the Bjerkreim-Sokndal layered intrusion (S. Norway). Part I. Constraints from major elements on the mechanism of cumulate formation and on the jotunite liquid line of descent
Duchesne, Jean-Clair ULg; Charlier, Bernard ULg

in Lithos (2005), 83(3-4), 229-254

Whole-rock major element compositions are investigated in 99 cumulates from the Proterozoic Bjerkreim-Sokndal layered intrusion (Rogaland Anorthosite Province, SW Norway), which results from the ... [more ▼]

Whole-rock major element compositions are investigated in 99 cumulates from the Proterozoic Bjerkreim-Sokndal layered intrusion (Rogaland Anorthosite Province, SW Norway), which results from the crystallization of a jotunite (Fe-Ti-P-rich hypersthene monzodiorite) parental magma. The scattering of cumulate compositions covers three types of cumulates: (1) ilmenite-leuconorite with plagioclase, ilmenite and Ca-poor pyroxene as cumulus minerals, (2) magnetite-leuconorite with the same minerals plus magnetite, and (3) gabbronorite made up of plagioclase, Ca-poor and Ca-rich pyroxenes, ilmenite, Ti-magnetite and apatite. Each type of cumulate displays a linear trend in variation diagrams. One pole of the linear trends is represented by plagioclase, and the other by a mixture of the mafic minerals in constant proportion. The mafic minerals were not sorted during cumulate formation though they display large density differences. This suggests that crystal settling did not operate during cumulate formation, and that in situ crystallization with variable nucleation rate for plagioclase was the dominant formation mechanism. The trapped liquid fraction of the cumulate plays a negligible role for the cumulate major element composition. Each linear trend is a locus for the cotectic composition of the cumulates. This property permits reconstruction by graphical mass balance calculation of the first two stages of the liquid line of descent, starting from a primitive jotunite, the Tjorn, parental magma. Another type of cumulate, called jotunite cumulate and defined by the mineral association from the Transition Zone of the intrusion, has to be subtracted to simulate the most evolved part of the liquid line of descent. The proposed model demonstrates that average cumulate compositions represent cotectic compositions when the number of samples is large (> 40). The model, however, does not account for the K2O evolution, suggesting that the system was open to contamination by roof melts. The liquid line of descent corresponding to the Bjerkreim-Sokndal cumulates differs slightly from that obtained for jotunitic dykes in that the most Ti-, P- and Fe-rich melts (evolved jotunite) are lacking. The constant composition of the mafic poles during intervals where cryptic layering is conspicuous is explained by a compositional balance between the Fe-Ti oxide minerals. which decrease in Fe content in favour of Ti. and the pyroxenes which increase in Fe. (c) 2005 Elsevier B.V. All rights reserved. [less ▲]

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See detailL'audition disciplinaire du fonctionnaire
Donnay, Luc ULg

in Administration Publique [=AP] : Revue du Droit Public et des Sciences Administratives (2005), (1), 61-75

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See detailRéseaux et souvenirs littéraires : le cas d'André Fontainas
Dozo, Björn-Olav ULg; de Marneffe, Daphné

in Textyles : Revue des Lettres Belges de Langue Française (2005), 26-27

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See detailQualitative assessment of the purity of multi-walled carbon nanotube samples using krypton adsorption
Gommes, Cédric ULg; Noville, Francis ULg; Bossuot, Christophe et al

in Studies in Surface Science and Catalysis (2005), 160

Krypton is a subcritical vapour at the nitrogen boiling temperature. As such, its adsorption on crystalline surfaces leads to condensation steps, typical of type VI isotherms according to IUPAC, while its ... [more ▼]

Krypton is a subcritical vapour at the nitrogen boiling temperature. As such, its adsorption on crystalline surfaces leads to condensation steps, typical of type VI isotherms according to IUPAC, while its adsorption on rough surfaces is BET-like. Based on this property of krypton adsorption at 77 K, a methodology is proposed to determine the purity of carbon nanotubes samples. The method is tested on model samples obtained by mixing mechanically purified multi-walled carbon nanotubes with various amounts of the same catalyst as used for their synthesis. [less ▲]

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See detailAnaemia management strategies: optimising treatment using epoetin beta (NeoRecormon).
Glaspy, John; Beguin, Yves ULg

in Oncology (2005), 69 Suppl 2

Anaemia has a detrimental impact on quality of life and it is important that this condition is recognised and treated in patients with cancer. Epoetin beta is an effective and well-tolerated treatment of ... [more ▼]

Anaemia has a detrimental impact on quality of life and it is important that this condition is recognised and treated in patients with cancer. Epoetin beta is an effective and well-tolerated treatment of anaemia in patients with a wide range of solid and haematological malignancies. A study in patients with lymphoid malignancies confirms that epoetin beta is equally effective at the same overall weekly dose (30,000 IU weekly) when given once-weekly or three-times weekly. This once-weekly regimen has also proved effective in patients with solid tumours. Once-weekly treatment is more convenient for the patient, potentially improving compliance and is associated with reduced hospital administration costs. The majority of patients with cancer will respond to epoetin therapy with an increase in haemoglobin levels. However, it is of value to identify those patients who are likely to respond, so that cost-effectiveness can be improved. Despite much research into potential predictive factors, follow-up studies are required and clinical judgement remains key to managing the anaemia of cancer. In addition, studies suggest that intravenous iron supplementation can improve response to epoetin therapy in patients with functional iron deficiency. Epoetin beta offers an effective, safe and convenient therapy for the management of anaemia in patients with cancer. Ongoing studies are expected to lead to a greater understanding of the optimal use of epoetins in cancer-related anaemia. [less ▲]

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See detailImmunotherapie du cancer par minigreffe de cellules souches hematopoietiques.
Willems, Evelyne ULg; Baron, Frédéric ULg; Vanstraelen, Gaëtan et al

in Revue Médicale Suisse (2005), 1(30), 1973-7

Allogeneic hematopoietic stem cell transplantation (HSCT) is used for the treatment of selected haematological malignancies. Its curative potential is based on two different mechanisms, i.e. the ... [more ▼]

Allogeneic hematopoietic stem cell transplantation (HSCT) is used for the treatment of selected haematological malignancies. Its curative potential is based on two different mechanisms, i.e. the conditioning regimen and the graft-versus-host immunologic reactions. However, because of its toxicity, it is restricted to younger and fitter patients. These observations led several groups to set up new (less toxic) transplant protocols. These transplants are called nonmyeloablative HSCT or minitransplants. These are feasible with a relatively low transplant-related mortality even in patients up to 70 years. In addition, strong anti-tumor responses are observed in several haematological malignancies. [less ▲]

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See detailPrimary amyloidosis (AL) as a cause of nephrotic syndrome.
Bataille, Yoann ULg; Bovy, Christophe ULg; Lancellotti, Patrizio ULg et al

in Acta Clinica Belgica (2005), 60(2), 94-7

AL amyloidosis is a rare systemic disease resulting from tissue accumulation of amyloid fibrils derived from monoclonal immunoglobulin light chains. It can disrupt the tissue architecture and consequently ... [more ▼]

AL amyloidosis is a rare systemic disease resulting from tissue accumulation of amyloid fibrils derived from monoclonal immunoglobulin light chains. It can disrupt the tissue architecture and consequently cause organ dysfunction. The prognosis is poor with a median survival of 13 months in untreated patients. By illustrating the case of a patient whose AL amyloidosis was detected after presenting a nephrotic syndrome, the characteristics of the disease are reviewed as well as diagnostic criteria and current available therapeutics. [less ▲]

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See detailInfluence of exogenous oestrogen or (anti-) androgen administration on soluble transferrin receptor in human plasma.
T'Sjoen, Guy; Beguin, Yves ULg; Feyen, Els et al

in Journal of Endocrinology (2005), 186(1), 61-7

The objective of this investigation was to study the effects of sex steroids on levels of haemoglobin (Hb) and haematocrit (Hct) and to analyse whether these effects can be related to levels of the ... [more ▼]

The objective of this investigation was to study the effects of sex steroids on levels of haemoglobin (Hb) and haematocrit (Hct) and to analyse whether these effects can be related to levels of the soluble transferrin receptor (sTfR), a marker of erythropoietic activity. Nineteen male-to-female transsexuals were randomly assigned to either oral ethinyl oestradiol (EE) (n=12) or transdermal 17beta-oestradiol (E2) (n=7); both treatments included the anti-androgen cyproterone acetate (CA). Six male-to-female transsexuals were treated with CA only. Fifteen female-to-male transsexuals were treated with i.m. testosterone esters. The Hct, and levels of Hb, IGF-I, GH and sTfR were measured before and after 4 months of hormone administration. Androgen administration significantly increased the sTfR concentration by 31.5% (P=0.008) and increased levels of Hct, Hb and IGF-I. Both regimens of CA with oral EE and transdermal E2 reduced plasma testosterone similarly to castrate values and decreased Hb and Hct. The CA+oral EE combination induced a decrease in sTfR of 19.0% (P=0.002) which was not the case with CA+transdermal E2 (P=0.27). This cannot be explained by the profound decline in plasma testosterone which was similar with both regimens, but this difference could be related to the different effects of the two regimens on plasma IGF-I. This assumption is supported by the positive correlation that was found to exist between plasma sTfR and IGF-I after the interventions (P<0.05). [less ▲]

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See detailLes neuroblastomes de l'enfant. A propos de 23 cas.
Piette, Catherine ULg; Dresse, Marie-Françoise ULg; Forget, Patricia ULg et al

in Revue Médicale de Liège (2005), 60(3), 173-80

In this retrospective study, we analyse epidemiology, clinical symptoms and therapeutic results in a group of 23 children with neuroblastoma. Half of them were less than 2 years of age; in 19 of 23, the ... [more ▼]

In this retrospective study, we analyse epidemiology, clinical symptoms and therapeutic results in a group of 23 children with neuroblastoma. Half of them were less than 2 years of age; in 19 of 23, the primitive tumour was abdominal; 35% of them were initially metastatic. The overall survival was 83% at 5 years and the event free survival, 75% at 5 years. Pronostic factors are age, extension of the disease at diagnosis, biologic parameters and genetic study of the neuroblast cells (amplification of N-myc oncogen). Our study shows the deleterious effect of bone lesions. [less ▲]

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See detailEfficacy of recombinant human erythropoietin therapy started one month after autologous peripheral blood stem cell transplantation.
Vanstraelen, Gaetan; Baron, Frédéric ULg; Frere, Pascale ULg et al

in Haematologica (2005), 90(9), 1269-70

On day 30 after autologous peripheral blood stem cell transplantation (PBSCT), 20 patients were randomized to receive either erythropoietin at a dose of 500 U/kg/week s.c. (Epo group) or no treatment ... [more ▼]

On day 30 after autologous peripheral blood stem cell transplantation (PBSCT), 20 patients were randomized to receive either erythropoietin at a dose of 500 U/kg/week s.c. (Epo group) or no treatment (control group). After 3 weeks, hemoglobin (p<0.0001) and serum transferrin receptor (p<0.0001) concentrations were higher in the Epo group. Hb response (+2 g/dL) was achieved in 100% vs 28% (p<0.0001) and Hb correction (> or =13 g/dL) in 70% vs 10% (p=0.0238) of the patients, respectively. This is the first randomized study showing an efficacy of erythropoietin therapy on Hb levels after autologous PBSCT. [less ▲]

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See detailAnalyse climatique de la région de Gouré, Niger oriental : récentes modifications et impacts environnementaux
Ozer, Pierre ULg; Bodart, Catherine ULg; Tychon, Bernard ULg

in Cybergeo : Revue Européenne de Géographie = Cybergeo - European Journal of Geography (2005)

Since the late 1960s, the Sahel is affected by a dramatic drought. This article analyses climatic variations recorded in the Gouré area, eastern Niger, between 1936 and 2003. It appears that the drought ... [more ▼]

Since the late 1960s, the Sahel is affected by a dramatic drought. This article analyses climatic variations recorded in the Gouré area, eastern Niger, between 1936 and 2003. It appears that the drought ended in the late 1980s. However, the rainfall increase did not lead to an extension of the length of the rainy season. The study of the wind shows that correct data were recorded during the two first years of the station of Gouré (1984 and 1985). Afterwards, wind speed was entached by errors and did not report since 1997. The situation is alarming as we know that neighbouring stations meet the same problems and that no synoptic station currently reports wind values in eastern Niger. However, based on wind speed and deflation data recorded in 1984, a threshold wind speed of 7 m/s was determined in Gouré. Finally, from measurements of horizontal visibility reduced by mineral dust, our results suggest that air quality is reduced because of the high frequency of wind erosion. The confrontation of our results with recent environmental studies in that region show that the end of the drought did not lead to any landscape improvement. Increasing human pressure tends to be the main driving factor of land degradation. [less ▲]

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See detailJean Le Blond, premier traducteur français de l'Utopie
Dozo, Björn-Olav ULg

in Lettres Romanes (2005), LIX(3-4), 187-210

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See detailConserving local goats breeds and traditional pastoralism in Southern France
Bertaglia, Marco; Mormont, Marc ULg; Trometter, Michel

in Agricoltura Mediterranea (2005), 135(2), 77-94

Extensive livestock productions is historically linked to local, traditional breeds. Both these production systems and traditional breeds have markedly declined or even disappeared in some areas, as a ... [more ▼]

Extensive livestock productions is historically linked to local, traditional breeds. Both these production systems and traditional breeds have markedly declined or even disappeared in some areas, as a result of global trends toward intensification, specialisation and abandonment of marginal areas. More recently, interest in the preservation of livestock biodiversity has been revived. Concern over the livelihood of marginal rural areas and landscape management accompanies the political debate over rare breeds. Parallel to institutional activity, and in many cases as forerunners, social actors have undertaken action to avoid both breed extinction and the loss of pastoralist traditions. In this paper, we present the findings of a qualitative survey of local goat husbandry in Southern France. Non-directive interviews of extension experts and breeders of two local goat breeds, the Rove and the Provençal, revealed a strong link between the breeders’ perception of local breeds/pastoralism and their broader worldview. Most breeders are “back-to-the-landers”. Their choice to raise local breeds in the pastoralist way is linked to a vision of society as a whole. Their account is interpreted as the will to resist to mainstream discourse and practice of rural development in marginal areas. [less ▲]

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See detailDe quelques aspects de droit pénal social et de procédure pénale susceptibles d'être rencontrés par le juge social ou le juge répressif
Michiels, Olivier ULg; Derre, Sylvie

in Revue Belge de Sécurité Sociale (2005), 2

On pourrait penser que les incidences du droit pénal social se limitent aux procédures menées devant les juridictions répressives. S’il est vrai que son terrain de prédilection demeure la sanction de ... [more ▼]

On pourrait penser que les incidences du droit pénal social se limitent aux procédures menées devant les juridictions répressives. S’il est vrai que son terrain de prédilection demeure la sanction de comportements pénalement répréhensibles, le droit pénal social présente toutefois différentes facettes. Ainsi, si la responsabilité pénale des personnes morales et les condamnations d’office prévues par la loi du 27 juin 1969 concernant la sécurité sociale des travailleurs relèvent des préoccupations immédiates du juge répressif, la notion de subordination, les amendes administratives ou encore l’autorité de chose jugée du pénal sur le civil, pour ne citer que ces trois exemples, procèdent de la pratique habituelle du juge civil. L'article a, dès lors, pour but de mettre en lumière plusieurs sujets qui, de près ou de loin, se ramifient au domaine répressif tout en ayant comme objectif d’appréhender la doctrine, la jurisprudence et la législation actuelles. [less ▲]

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See detailImpact of pro-oxidant agents on the morula-blastocyst transition in bovine embryos.
Feugang, Jean-Magloire; Donnay, Isabelle; Mermillod, Pascal et al

in Molecular Reproduction and Development (2005), 71(3), 339-46

Exposing day 5 bovine morulae to reactive oxygen species induces a delayed degeneration of some blastocysts on day 8 post-insemination (pi) but without affecting the blastocyst rates. The aim of this ... [more ▼]

Exposing day 5 bovine morulae to reactive oxygen species induces a delayed degeneration of some blastocysts on day 8 post-insemination (pi) but without affecting the blastocyst rates. The aim of this study was to characterize the resisting and the degenerating population of blastocysts. The kinetics of degeneration of the embryos exposed to the two pro-oxidant agents: 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH) and buthionine sulfoximine (BSO) was evaluated using time-lapse cinematography. With both agents the first signs of degeneration appeared at day 7.5 pi but the duration of the degeneration process was shorter in presence of AAPH than BSO (4.2 vs. 12.5 hr, ANOVA, P < 0.05). The resisting blastocysts derived from morulae with a larger diameter (mean diameter: 161 vs. 154 microm, ANOVA, P < 0.05) and showed an earlier cavitation (135 vs. 142 hpi, P < 0.05) than the degenerating ones. The profile of protein neosynthesis at day 7 was not affected by the treatment. The proportion of male embryos was more important in the resisting than in the degenerating population (70 vs. 55%, chi2, P < 0.05) especially when the stress was induced by AAPH. The quality of the resisting embryos, measured by the total cell number and the rate of apoptosis, did not seem to be affected when compared to control embryos. In conclusion, resistance to oxidative stress seems related to the kinetics of development and/or the sex of the embryos. Resisting embryos apparently display a quality similar to untreated embryos. [less ▲]

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See detailPorcine embryo development and fragmentation and their relation to apoptotic markers: a cinematographic and confocal laser scanning microscopic study.
Mateusen, Bart; Van Soom, Ann; Maes, Dominiek G D et al

in Reproduction (Cambridge, England) (2005), 129(4), 443-52

Porcine embryo selection prior to transfer is mainly influenced by morphological criteria. However, the relationship between embryonic morphology, developmental potential and cell death by apoptosis in ... [more ▼]

Porcine embryo selection prior to transfer is mainly influenced by morphological criteria. However, the relationship between embryonic morphology, developmental potential and cell death by apoptosis in porcine embryos is still unclear. The aim of this study was to establish embryo quality parameters for in vivo fertilised porcine embryos based on timing of development in vitro, embryo morphology and the presence of apoptosis. The kinetics of development and morphological parameters were investigated in a time-lapse cinematographic experiment. Possible links between embryo morphology and apoptosis were examined via a confocal laser scanning experiment, analysing nuclear changes, annexin V and terminal dUTP nick-end labelling. The timing of early cleavages was firmly linked to embryo developmental competence in vitro. Attainment of at least the 5-cell stage before 77 h post insemination and attainment of the morula stage before 102 h post insemination significantly increased the odds for reaching the early blastocyst stage. Overall, a negative effect of fragmentation percentage and fragmentation pattern on subsequent embryonic development was observed, but the developmental potential of embryos experiencing slight fragmentation (0-5%) was not different from embryos without fragmentation. Correlations detected between developmental arrest and fragmentation, and fragmentation and apoptosis were 0.60 and 0.87 (P < 0.05) respectively. Only a minority of the embryos arrested between the 1- and 4-cell stage displayed biochemical characteristics of apoptosis. Consequently, a significant correlation (0.57) between developmental arrest and apoptosis could only be established for embryos arrested after embryonic genome activation. [less ▲]

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See detailEffects of polyadenylation inhibition on meiosis progression in relation to the polyadenylation status of cyclins A2 and B1 during in vitro maturation of bovine oocytes.
Traverso, Juan M; Donnay, Isabelle; Lequarré, Anne-Sophie ULg

in Molecular Reproduction and Development (2005), 71(1), 107-14

The control of protein synthesis during maturation in oocytes is mainly exerted through cytoplasmic polyadenylation of stored mRNAs. We first analyzed the polyadenylation status of cyclins A2 and B1 ... [more ▼]

The control of protein synthesis during maturation in oocytes is mainly exerted through cytoplasmic polyadenylation of stored mRNAs. We first analyzed the polyadenylation status of cyclins A2 and B1 during in vitro maturation (IVM) of bovine oocytes, using Rapid Amplification of cDNA Ends-Polyadenylation Technique (RACE-PAT). An inconstant elongation of the poly(A) tail was observed for cyclin A2 transcripts after maturation, while a constant lengthening was observed for cyclin B1, occurring during the first 12 hr of incubation. We then evaluated the effects of the polyadenylation inhibitor 3'-deoxyadenosine (3'-dA), on polyadenylation and nuclear maturation. The presence of 0.02 mM 3'-dA during the whole incubation period or from 6 hr after its beginning completely prevented meiosis progression in 100% of the oocytes. Polyadenylation of cyclin B1 was also completely prevented when 3'-dA was added at 0 hr, and greatly reduced when added at 6 hr. When 3'-dA was added at 12 hr, around metaphase I (MI), 46.9% of the oocytes have reached metaphase II (MII, vs. 78.8% in the control group) at 24 hr. The use of the same concentration of 3'-deoxyguanosine (3'-dG), that impairs transcription but not polyadenylation, did not affect cyclins polyadenylation, nor nuclear maturation, whatever was the timing of addition. These results suggest that the polyadenylation of cyclin B1 could be related to the first peak of activity of MPF, occurring around MI (10-12 hr after the onset of the maturation period). They also show that, in our culture conditions, inhibition of polyadenylation prevents meiosis progression, especially up to the MI stage, while inhibition of transcription does not. [less ▲]

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See detailInfluence of antral follicle size on oocyte characteristics and embryo development in the bovine.
Lequarré, Anne-Sophie ULg; Vigneron, Celine; Ribaucour, Fabrice et al

in Theriogenology (2005), 63(3), 841-59

The developmental competence of bovine oocytes isolated from antral follicles of different sizes was assessed in three European laboratories (Belgium, UCL; Denmark, DIAS; France, INRA). Using the same ... [more ▼]

The developmental competence of bovine oocytes isolated from antral follicles of different sizes was assessed in three European laboratories (Belgium, UCL; Denmark, DIAS; France, INRA). Using the same protocol for in vitro production of embryos, the oocytes isolated from follicles with a diameter > or = 6 mm always gave a higher blastocyst rate than oocytes from follicles < 4 mm (UCL: 42% versus 14%, DIAS: 50% versus 35%, INRA: 39% versus 22%; P < 0.05). Blastocyst cell number was not affected by follicle size. Several parameters were investigated for these oocytes. The energy metabolism of cumulus-oocyte-complexes and of denuded oocytes was assessed by the oxygen and pyruvate uptake and by lactate release both at the beginning and the end of the maturation. No effect of follicle size could be detected but lactate release increased after maturation. The global profile of transcripts, the pattern of protein neosynthesis and the kinetics of meiosis resumption were not affected by follicle size. The developmental kinetics of derived embryos was also analysed. Whatever the follicle size, viable embryos had a shorter first and third embryonic cell cycle. Among the viable embryos, the size of the follicle interfered with the fourth cell cycle duration. A higher percentage of blastocysts issued from large follicle presented a short fourth cell cycle (9h) (35% versus 6%; P < 0.05). Beside, blastocysts derived from small follicles had a delayed cavitation and expansion. Thereby, a higher developmental competence for oocytes from follicle > or = 6 mm versus < 4 mm was demonstrated in three laboratories although no differences could be displayed directly at the oocyte level. [less ▲]

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