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See detailAcute tubular dysfunction wtih Fanconi syndrome : a new manifestation of mitochondrial cytopathies
Debray, François-Guillaume ULg; Merouani, A.; Lambert, M. et al

in American Journal of Kidney Diseases (2008), 51(4), 691-696

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See detailMale-biased genes are overrepresented among novel Drosophila pseudoobscura sex-biased genes.
Metta, Muralidhar ULg; Schlotterer, Christian

in BMC Evolutionary Biology (2008), 8

BACKGROUND: The origin of functional innovation is among the key questions in biology. Recently, it has been shown that new genes could arise from non-coding DNA and that such novel genes are often ... [more ▼]

BACKGROUND: The origin of functional innovation is among the key questions in biology. Recently, it has been shown that new genes could arise from non-coding DNA and that such novel genes are often involved in male reproduction. RESULTS: With the aim of identifying novel genes, we used the technique "generation of longer cDNA fragments from serial analysis of gene expression (SAGE) tags for gene identification (GLGI)" to extend 84 sex-biased 3'end SAGE tags that previously could not be mapped to the D. pseudoobscura transcriptome. Eleven male-biased and 33 female-biased GLGI fragments were obtained, of which 5 male-biased and 3 female-biased tags corresponded to putatively novel genes. This excess of novel genes with a male-biased gene expression pattern is consistent with previous results, which found novel genes to be primarily expressed in male reproductive tissues. 5' RACE analysis indicated that these novel transcripts are very short in length and could contain introns. Interspecies comparisons revealed that most novel transcripts show evidence for purifying selection. CONCLUSION: Overall, our data indicate that among sex-biased genes a considerable number of novel genes (approximately 2-4%) exist in D. pseudoobscura, which could not be predicted based on D. melanogaster gene models. [less ▲]

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See detailGenetic evidence from Indian red jungle fowl corroborates multiple domestication of modern day chicken.
Kanginakudru, Sriramana; Metta, Muralidhar ULg; Jakati, R. D. et al

in BMC Evolutionary Biology (2008), 8

BACKGROUND: Domestication of chicken is believed to have occurred in Southeast Asia, especially in Indus valley. However, non-inclusion of Indian red jungle fowl (RJF), Gallus gallus murghi in previous ... [more ▼]

BACKGROUND: Domestication of chicken is believed to have occurred in Southeast Asia, especially in Indus valley. However, non-inclusion of Indian red jungle fowl (RJF), Gallus gallus murghi in previous studies has left a big gap in understanding the relationship of this major group of birds. In the present study, we addressed this issue by analyzing 76 Indian birds that included 56 G. g. murghi (RJF), 16 G. g. domesticus (domestic chicken) and 4 G. sonneratii (Grey JF) using both microsatellite markers and mitochondrial D-loop sequences. We also compared the D-loop sequences of Indian birds with those of 779 birds obtained from GenBank. RESULTS: Microsatellite marker analyses of Indian birds indicated an average FST of 0.126 within G. g. murghi, and 0.154 within G. g. domesticus while it was more than 0.2 between the two groups. The microsatellite-based phylogenetic trees showed a clear separation of G. g. domesticus from G. g. murghi, and G. sonneratii. Mitochondrial DNA based mismatch distribution analyses showed a lower Harpending's raggedness index in both G. g. murghi (0.001515) and in Indian G. g. domesticus (0.0149) birds indicating population expansion. When meta analysis of global populations of 855 birds was carried out using median joining haplotype network, 43 Indian birds of G. g. domesticus (19 haplotypes) were distributed throughout the network sharing haplotypes with the RJFs of different origins. CONCLUSION: Our results suggest that the domestication of chicken has occurred independently in different locations of Asia including India. We found evidence for domestication of Indian birds from G. g. spadiceus and G. g. gallus as well as from G. g. murghi, corroborating multiple domestication of Indian and other domestic chicken. In contrast to the commonly held view that RJF and domestic birds hybridize in nature, the present study shows that G. g. murghi is relatively pure. Further, the study also suggested that the chicken populations have undergone population expansion, especially in the Indus valley. [less ▲]

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See detailBluetongue virus antibodies in wild red deer in southern Belgium
Linden, Annick ULg; Mousset, B.; Grégoire, Fabien ULg et al

in Veterinary Record : Journal of the British Veterinary Association (2008)

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See detailLes réseaux d’épidémiosurveillance des maladies animales en Afrique francophone de l’Ouest et du Centre
Ouagal, M.; Hendrikx, P.; Berkvens, B. et al

in Revue Scientifique et Technique (International Office of Epizootics) (2008), 27(3), 689-702

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See detailTranscatheter valve implantation for patients with aortic stenosis: a position statement from the European Association of Cardio-Thoracic Surgery (EACTS) and the European Society of Cardiology (ESC), in collaboration with the European Association of Percutaneous Cardiovascular Interventions (EAPCI).
Vahanian, Alec; Alfieri, Ottavio; Al-Attar, Nawwar et al

in European Heart Journal (2008), 29(11), 1463-70

AIMS: To critically review the available transcatheter aortic valve implantation techniques and their results, as well as propose recommendations for their use and development. METHODS AND RESULTS: A ... [more ▼]

AIMS: To critically review the available transcatheter aortic valve implantation techniques and their results, as well as propose recommendations for their use and development. METHODS AND RESULTS: A committee of experts including European Association of Cardio-Thoracic Surgery and European Society of Cardiology representatives met to reach a consensus based on the analysis of the available data obtained with transcatheter aortic valve implantation and their own experience. The evidence suggests that this technique is feasible and provides haemodynamic and clinical improvement for up to 2 years in patients with severe symptomatic aortic stenosis at high risk or with contraindications for surgery. Questions remain mainly concerning safety and long-term durability, which have to be assessed. Surgeons and cardiologists working as a team should select candidates, perform the procedure, and assess the results. Today, the use of this technique should be restricted to high-risk patients or those with contraindications for surgery. However, this may be extended to lower risk patients if the initial promise holds to be true after careful evaluation. CONCLUSION: Transcatheter aortic valve implantation is a promising technique, which may offer an alternative to conventional surgery for high-risk patients with aortic stenosis. Today, careful evaluation is needed to avoid the risk of uncontrolled diffusion. [less ▲]

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See detailTranscatheter valve implantation for patients with aortic stenosis: a position statement from the European Association of Cardio-Thoracic Surgery (EACTS) and the European Society of Cardiology (ESC), in collaboration with the European Association of Percutaneous Cardiovascular Interventions (EAPCI).
Vahanian, Alec; Alfieri, Ottavio R; Al-Attar, Nawwar et al

in European Journal of Cardio - Thoracic Surgery (2008), 34(1), 1-8

AIMS: To critically review the available transcatheter aortic valve implantation techniques and their results, as well as propose recommendations for their use and development. METHODS AND RESULTS: A ... [more ▼]

AIMS: To critically review the available transcatheter aortic valve implantation techniques and their results, as well as propose recommendations for their use and development. METHODS AND RESULTS: A committee of experts including European Association of Cardio-Thoracic Surgery and European Society of Cardiology representatives met to reach a consensus based on the analysis of the available data obtained with transcatheter aortic valve implantation and their own experience. The evidence suggests that this technique is feasible and provides haemodynamic and clinical improvement for up to 2 years in patients with severe symptomatic aortic stenosis at high risk or with contraindications for surgery. Questions remain mainly concerning safety and long-term durability, which have to be assessed. Surgeons and cardiologists working as a team should select candidates, perform the procedure, and assess the results. Today, the use of this technique should be restricted to high-risk patients or those with contraindications for surgery. However, this may be extended to lower risk patients if the initial promise holds to be true after careful evaluation. CONCLUSION: Transcatheter aortic valve implantation is a promising technique, which may offer an alternative to conventional surgery for high-risk patients with aortic stenosis. Today, careful evaluation is needed to avoid the risk of uncontrolled diffusion. [less ▲]

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See detailHighlights of the 2008 Scientific Sessions of the European Society of Cardiology Munich, Germany, August 30 to September 3, 2008.
Kristensen, Steen D; Baumgartner, Helmut; Casadei, Barbara et al

in Journal of the American College of Cardiology (2008), 52(24), 2032-42

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See detailDeterminants of an abnormal response to exercise in patients with asymptomatic valvular aortic stenosis.
Lancellotti, Patrizio ULg; Karsera, Danai; Tumminello, Gabriele et al

in European Journal of Echocardiography (2008), 9(3), 338-43

AIM: Patients with asymptomatic aortic stenosis (AS) and abnormal haemodynamic responses to exercise testing are at increased risk of cardiac events. This study assesses the Doppler echocardiographic ... [more ▼]

AIM: Patients with asymptomatic aortic stenosis (AS) and abnormal haemodynamic responses to exercise testing are at increased risk of cardiac events. This study assesses the Doppler echocardiographic determinants of a positive exercise test in a cohort of asymptomatic patients with AS. METHODS AND RESULTS: One hundred and twenty-eight patients with AS underwent quantitative Doppler echocardiographic measurements at rest and during exercise test. Of these patients, 60 had an abnormal response to exercise. Two independent determinants of an abnormal exercise response were selected in multivariate analysis: a larger increase in mean transaortic pressure gradient (P = 0.00014) and a limited contractile reserve-latent left ventricular dysfunction-as indicated by smaller changes in ejection fraction (P = 0.0002). Limiting symptoms were associated with greater increase in mean transaortic pressure gradient, smaller changes in systolic blood pressure and a lower ejection fraction at peak exercise. The increase in pressure gradient was associated with smaller exercise-induced changes in aortic valve area and in ejection fraction and new or worsening mitral regurgitation during exercise. CONCLUSION: Abnormal responses to exercise in asymptomatic AS patients are mediated by a larger increase in mean transaortic pressure gradient and/or a limited contractile reserve characterized by an inadequate increase in ejection fraction at exercise. [less ▲]

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See detailGermline PTPN11 missense mutation in a case of Noonan syndrome associated with mediastinal and retroperitoneal neuroblastic tumors.
Mutesa, Léon; Pierquin, Geneviève ULg; Janin, Nicolas ULg et al

in Cancer Genetics & Cytogenetics (2008), 182(1), 40-2

Noonan syndrome (NS) is an autosomal dominant disorder characterized by short stature, typical craniofacial dysmorphism, skeletal anomalies, congenital heart defects, and predisposition to malignant ... [more ▼]

Noonan syndrome (NS) is an autosomal dominant disorder characterized by short stature, typical craniofacial dysmorphism, skeletal anomalies, congenital heart defects, and predisposition to malignant tumors. In approximately 50% of cases, the disease is caused by missense mutations in the PTPN11 gene. To date, solid tumors, and particularly brain tumors and rhabdomyosarcomas, have been documented in patients with NS; however, few cases of neuroblastoma associated with NS have been reported. Here we report an unusual case of neuroblastoma with mediastinal, retroperitoneal, and medullar locations associated in a NS patient carrying a PTPN11 germline missense mutation (p.G60A). This missense mutation occurs within the N-SH2 domain of the PTPN11 gene and has been reported to be associated with acute leukemia in NS patients. The association of this p.G60A PTPN11 mutation with neuroblastoma provides new evidence that gain of function PTPN11 mutations may play an important role in the pathogenesis of solid tumors associated with Noonan syndrome. [less ▲]

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See detailChromosomal profiles of gene expression in Huntington's disease.
Anderson, Alexander N; Roncaroli, Federico; Hodges, Angela et al

in Brain : A Journal of Neurology (2008), 131(Pt 2), 381-8

Recent studies suggested that Huntington's disease is due to aberrant interactions between mutant huntingtin protein, transcription factors and transcriptional co-activators resulting in widespread ... [more ▼]

Recent studies suggested that Huntington's disease is due to aberrant interactions between mutant huntingtin protein, transcription factors and transcriptional co-activators resulting in widespread transcriptional dysregulation. Mutant huntingtin also interacts with histone acetyltransferases, consequently interfering with the acetylation and deacetylation states of histones. Because histone modifications and chromatin structure coordinate the expression of gene clusters, we have applied a novel mathematical approach, Chromowave, to analyse microarray datasets of brain tissue and whole blood to understand how genomic regions are altered by the effects of mutated huntingtin on chromatin structure. Results show that, in samples of caudate and whole blood from Huntington's disease patients, transcription is indeed deregulated in large genomic regions in coordinated fashion, that transcription in these regions is associated with disease progression and that altered chromosomal clusters in the two tissues are remarkably similar. These findings support the notion of a common genome-wide mechanism of disruption of RNA transcription in the brain and periphery of Huntington's disease patients. [less ▲]

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See detailServices de proximité et régulation publique
Henry, Arnaud ULg

in Non-marchand (2008), 6

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See detailCaracterización y cuantificación autmatizadas de menas metálicas mediante visión artificial : proyecto cameva
Castroviejo, Ricardo; Catalina, Juan-Carlos; Bernhardt, Heinz-Juergen et al

in Actos del XIII Congreso Latino Americano de Geologia (2008)

The CAMEVA project (Automated system for the identification and quantitative measurement of ore minerals) aims to develop an automated system able to perform the identification and quantification of the ... [more ▼]

The CAMEVA project (Automated system for the identification and quantitative measurement of ore minerals) aims to develop an automated system able to perform the identification and quantification of the different minerals present in a sample of metallic ores, in order to facilitate their industrial use. The system comprises a motorised reflected light microscope, a filter wheel (monochromator), a research BW camera, and a computer running a digital image analysis software associated to an expert system specially developed for this application. Multispectral reflectance values are measured for visible light and near IR and UV (350-1000 nm), and no polarisation is usually employed in order to reduce measurement variability due to mineral anisotropy. Mineral identification is carried out by comparison of measured reflectances with spectral reflectance databases (e.g. IMA-COM). Previous experiences showed that the most common ores can be differentiated through the analysis of a microscopic RGB colour image, by constraining the search with additional information such as the type of deposit and the corresponding mineral association. The project goes further, and intends to identify most of the ores from multi-spectral images, including non-visible bands, resorting to an expert system specifically built to deal with the different types of information available (spectral reflectance, sample origin, mineral associations, morphology, etc). 2 Validation of the method will be carried out by comparative análisis of standards and samples exchanged between the laboratories. Development pays special attention to the total automation of the process (including calibration) and to the self-learning capabilities of the system. Contacts with research institutions and with the industry will allow to apply the system to real problems. The system can be used to control the processing of ores as well as to prevent pollution for the protection of the environment (e.g. sulphides in coal or in industrial tailings). Further applications can be envisaged in the future: e.g. other minerals, coal or materials, particles, etc. [less ▲]

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See detailLa France et l'OTAN : vers la normalisation ?
Dumoulin, André ULg

in Courrier Hebdomadaire du CRISP (2008), 2005

En 1966, la France se retire du commandement intégré de l’OTAN. Son actuelle réintégration n’est pas une rupture ni le fruit d’une révolution spectaculaire récente, mais plutôt l’aboutissement d’un ... [more ▼]

En 1966, la France se retire du commandement intégré de l’OTAN. Son actuelle réintégration n’est pas une rupture ni le fruit d’une révolution spectaculaire récente, mais plutôt l’aboutissement d’un processus engagé par François Mitterrand et poursuivi par Jacques Chirac. En fait, la politique française a toujours joué sur plusieurs plans, entre indépendance nationale, soutien à la défense européenne et engagements au sein de l’Alliance. La dimension « autonomie européenne » a toujours fait l’objet du soutien important de la part de Paris, avec des résultats qui ne furent pas toujours à la hauteur des ambitions. Depuis la fin de la Guerre froide et le 11 septembre 2001, le paysage a changé. Les États-Unis ont compris que sans les Européens, il n’y a pas beaucoup d’alliés sur qui compter pour disposer d’une armée crédible et qui s’engage sur le terrain. De son côté, Paris a pris des initiatives pragmatiques sur des dossiers opérationnels, techniques et militaires durant la présidence du Conseil de l’Union européenne au second semestre 2008, sortant ainsi des grands concepts idéologiques européistes. Le dossier examine la dimension historique de la place de la France dans l’organisation euro-atlantique, l’évolution de la position hexagonale dans les années 1990, les débats engagés entre 2007 et 2009, les argumentaires (favorables et négatifs) des partis politiques, les hypothèses et les scénarios à propos de la « normalisation » française autour du sommet de l’Alliance atlantique à Strasbourg-Kehl en avril 2009. [less ▲]

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See detailHolocene records of regional dust deposition using peat bogs
Le Roux, G.; De Vleeschouwer, François; Cheburkin, A. et al

in Geochimica et Cosmochimica Acta (2008), 72(12), 535-535

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See detailSerum dioxin and PCB levels among PCB waste processing plant workers
Eppe, Gauthier ULg; Dupas, D.; Chisacof, I. et al

in Organohalogen Compounds (2008), 70

A clinical investigation and a biological monitoring were carried out to evaluate the occupational exposure of workers in contact with pyralen in a PCB-transformer and capacitor decontamination plant in ... [more ▼]

A clinical investigation and a biological monitoring were carried out to evaluate the occupational exposure of workers in contact with pyralen in a PCB-transformer and capacitor decontamination plant in France. The aim of this study was to assess the body burden of polychlorinated dibenzo-p- dioxin (PCDDs), polychlorinated dibenzofurans (PCDFs), dioxin-like (DL) PCBs and marker PCBs for those workers. We examined 8 representative workers (34-44 years old). The subjects of this study worked from 5 years to 19 years at the plant. All workers reported daily multiple contacts with various metal and wood parts of dismantled transformers during working hours. On a yearly basis, the exposed subjects were examined by the occupational health physician for a check-up. Basic parameters such as liver function and lipid statement were performed. [less ▲]

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See detailLevels of PCDD/Fs and DL-PCBs in Belgian river eel specimen
Focant, Jean-François ULg; Geererts, C.; Eppe, Gauthier ULg et al

in Organohalogen Compounds (2008), 70

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See detailThe wave function of $[70,1^-]$ baryons in the $1/N_c$ expansion
Matagne, Nicolas; Stancu, Floarea ULg

in Phys. Rev. (2008), D77

Much work has been devoted to the study of nonstrange baryons belonging to the $[\textbf{70},1^-]$ multiplet in the framework of the $1/N_c$ expansion. Using group theoretical arguments here we examine ... [more ▼]

Much work has been devoted to the study of nonstrange baryons belonging to the $[\textbf{70},1^-]$ multiplet in the framework of the $1/N_c$ expansion. Using group theoretical arguments here we examine the relation between the exact wave function and the approximate one, customarily used in applications where the system is separated into a ground state core and an excited quark. We show that the exact and approximate wave functions globally give similar results for all of mass operators presented in this work. However we find that the inclusion of operators acting separately on the core and on the excited quark deteriorates the fit and leads to unsatisfactory values for the coefficients which encode the quark dynamics. Much better results are obtained when we include operators acting on the whole system, both for the exact and the approximate wave function. [less ▲]

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See detailNew look at the (70,1-) baryon multiplet in the 1/N(c) expansion
Matagne, Nicolas; Stancu, Floarea ULg

in Nucl. Phys. (2008), A811

So far, the masses of excited states of mixed orbital symmetry and in particular those of nonstrange $[{\bf 70},1^-]$ baryons derived in the $1/N_c$ expansion were based on the separation of a system of ... [more ▼]

So far, the masses of excited states of mixed orbital symmetry and in particular those of nonstrange $[{\bf 70},1^-]$ baryons derived in the $1/N_c$ expansion were based on the separation of a system of $N_c$ quarks into a symmetric core and an excited quark. Here we avoid this separation and show that an advantage of this new approach is to substantially reduce the number of linearly independent operators entering the mass formula. A novelty is that the isospin-isospin term becomes as dominant in $\Delta$ as the spin-spin term in $N$ resonances. [less ▲]

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