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See detailModulation of fMRI assessed brain responses to blue and green light by sleep homeostasis, circadian phase and PER3 polymorphism
Vandewalle, Gilles ULg; Archer, Simon; Wuillaume, Catherine et al

in Sleep (2009), 32(Suppl. 1),

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See detailEvaluation of the antiproliferative effects of infusions and essential oil of Aloysia gratissima
Hister, CAL; Laughinghouse IV, Haywood ULg; Silva, CB et al

in Pakistan Journal of Biological Sciences (2009), 12(24), 1581-1584

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See detailLes thrombopénies induites par l'héparine (TIH)
Baccus, Christine ULg; Hans, Pol ULg; Brichant, Jean-François ULg

in Revue Médicale de Liège (2009), 64(9), 450-456

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See detailBifurcation analysis of a periodically forced relaxation oscillator: Differential model versus phase-resetting map
Croisier, H.; Guevara, M. R.; Dauby, Pierre ULg

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2009), 79(1),

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See detailLes psychoses delirantes chroniques.
Desseilles, Martin ULg; Massart, Nicolas ULg

in Revue Médicale de Liège (2009), 64(9), 464-7

The current Anglo-Saxon trend is to consider that schizophrenia includes all psychoses. However, far from being a uniform set, there is a lot of different clinical presentations of patients with psychosis ... [more ▼]

The current Anglo-Saxon trend is to consider that schizophrenia includes all psychoses. However, far from being a uniform set, there is a lot of different clinical presentations of patients with psychosis. Chronic delusional psychosis, as a paradigm, show that subtyping psychosis on a clinical basis is useful for therapeutic and prognosis purposes. [less ▲]

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See detailN-REM sleep slow oscillations amplitude and density in the young and middle-aged men and women
Viens, I; Lafortune, M; Poirier, G et al

in Sleep (2009), 32(Suppl. 1),

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See detailPromenade insolite dans le paysage muséal
Drouguet, Noémie ULg

in Vie des Musées (La) (2009), 21

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See detailRenal insufficiency after cardiac surgery: a challenging clinical problem.
Kolh, Philippe ULg

in European Heart Journal (2009), 30(15), 1824-7

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See detailModeling Daily Traffic Counts: Analyzing the Effects of Holidays
Cools, Mario ULg; Moons, Elke; Wets, Geert

in Sloboda, Brian (Ed.) Transportation Statistics (2009)

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See detailAspects juridiques de la publication scientifique : Guide pratique à l'attention des membres de la communauté universitaire
Thys, Laurence ULg

Book published by Conseil Interuniversitaire de la Communauté française (2009)

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See detailVitamin D: current status and perspectives.
Cavalier, Etienne ULg; Delanaye, Pierre ULg; Chapelle, Jean-Paul ULg et al

in Clinical Chemistry & Laboratory Medicine (2009), 47(2), 120-127

Abstract The role of vitamin D in maintaining bone health has been known for decades. Recently, however, the discovery that many tissues expressed the vitamin D receptor and were able to transform the 25 ... [more ▼]

Abstract The role of vitamin D in maintaining bone health has been known for decades. Recently, however, the discovery that many tissues expressed the vitamin D receptor and were able to transform the 25-OH vitamin D into its most active metabolite, 1,25-(OH)(2) vitamin D, has led to a very promising future for this "old" molecule. Indeed, observational studies, and more and more interventional studies, are raising the importance of a significant vitamin D supplementation for not-only skeletal benefits. Among them, 25-OH vitamin D has been found to play an important role in prevention of cancers, auto-immune diseases, cardiovascular diseases, diabetes, and infections. Vitamin D deficiency, defined as serum 25-OH vitamin D levels <30 ng/mL, is very common in our population. The cost/benefit ratio and some recently published studies are clearly now in favor of a controlled and efficient vitamin D supplementation in these patients presenting a 25-OH vitamin D level <30 ng/mL. More attention should also be focused on pregnant and lactating women, as well as children and adolescents. Clin Chem Lab Med 2009;47. [less ▲]

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See detailInfluence of medium composition on oxygen transfer rate in animal cell culture
Toye, Dominique ULg; Galifi, Alain; Salmon, Thierry ULg et al

in Proceedings of 8th World Congress on Chemical Engineering (2009)

Experiments were conducted in a 0.25 m diameter bubble column to investigate the effect of animal cell culture medium composition on oxygen transfer rate. Air is used as the dispersed phase. The gas ... [more ▼]

Experiments were conducted in a 0.25 m diameter bubble column to investigate the effect of animal cell culture medium composition on oxygen transfer rate. Air is used as the dispersed phase. The gas superficial velocity is varied between 0.4 and 2 cm/s (aeration rate ranging between 0.05 and 0.25 vvm) and the bubble column is thus operated in the homogenous regime. Aqueous solutions the composition (electrolyte, protein concentrations) of which mimics a mammalian cell culture medium) are used as the continuous phase. In particular, the effect on oxygen transfer rate of additive such as PVP, Pluronic F-68 which are usually used to protect cells against local hydrodynamic stresses induced by bubble coalescence and bursting is addressed. For each composition, the mass transfer coefficient is measured by the "gas in – gas out" method using a fast response dissolved oxygen probe. Its increase with gas velocity is measured. The liquid viscosity and surface tension are experimentally determined as a function of culture medium composition. Bubble size distribution is measured at different scales using three experimental techniques: gas disengagement technique, two dual optical probes and photography, which lead to results in good qualitative agreement one with each other. The integrated analysis of these data allows to decouple the effects of the different additive on coefficient kL and on the interfacial area, a. [less ▲]

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See detailProduction of freeze-dried lactic acid bacteria starter culture for cassava fermentation into gari.
Yao, Amenan Anastasie ULg; Dortu, Carine; Egounlety, Moutairu et al

in African Journal of Biotechnology (2009), 8(19), 4996-5004

Sixteen lactic acid bacteria, eight Lactobacillus plantarum, three L. pentosus, 2 Weissella paramesenteroides, two L. fermemtum and one Leuconostoc mesenteroides ssp. mesenteroides were previously ... [more ▼]

Sixteen lactic acid bacteria, eight Lactobacillus plantarum, three L. pentosus, 2 Weissella paramesenteroides, two L. fermemtum and one Leuconostoc mesenteroides ssp. mesenteroides were previously isolated from cassava fermentation and selected on the basis of their biochemical properties with a view to selecting appropriate starter cultures during cassava fermentation for gari production. In this study, the potential of these pre-selected strains as suitable freeze-dried cultures was evaluated. Their ability to tolerate the freeze-drying process was assessed by dehydration in a glycerol solution of increasing concentration, followed by staining with two fluorescent markers: rhodamine 123 and propydium iodide. Twelve strains that recovered more than 50% of their population value after visualisation on an epi-fluorescent microscope were produced in a bioreactor and freeze-dried. The technological characteristics identified after the freeze-drying process, were a high cell concentration or high survival rate. The ability of the freeze-dried strains to recover their acidification activity was evaluated through the determination of the pH, titratable acidity (% lactic acid/g Dry Weight) and cell count over 24 h on MRS broth. Ultimately, the strains L. plantarum VE36, G2/25, L. fermentum G2/10 and W. paramesenteroides LC11 were selected to be developed as freeze-dried starter cultures for gari production. [less ▲]

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See detailComent j'explore...- les pertes de sang d'origine vaginale dans l'enfance
Pelletier, R.; Foidart, Jean-Michel ULg; Nisolle, Michelle ULg

in Revue Médicale de Liège (2009), 64(4), 219-22

Le saignement vaginal prépubertaire est considéré comme une ménarche isolée lorsque, en l’absence de toute anomalie mise en évidence par les examens médicaux (corps étranger, tumeur, infection…), il n’y ... [more ▼]

Le saignement vaginal prépubertaire est considéré comme une ménarche isolée lorsque, en l’absence de toute anomalie mise en évidence par les examens médicaux (corps étranger, tumeur, infection…), il n’y pas de développement d’un autre caractère sexuel secondaire. Si d’autres signes pubertaires (thélarche, pubarche, pic de croissance, …) se développent, le saignement vaginal ne sera plus isolé et nous parlerons dès lors de puberté précoce vraie. C’est donc le suivi de la patiente qui nous permettra de faire le diagnostic différentiel entre ménarche précoce isolée bénigne et puberté précoce vraie engageant le pronostic statural et nécessitant une prise en charge spécifique. L’étiologie de la ménarche isolée reste indéterminée et des études complémentaires sont nécessaires. Plusieurs examens complémentaires doivent être réalisés afin d’exclure des pathologies tumorales, infectieuses, traumatiques ou encore hormonales et ceux-ci doivent être répétés lors du suivi de la patiente. [less ▲]

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See detailGenetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis.
Villani, Alexandra-Chloé; Lemire, Mathieu; Louis, Edouard ULg et al

in PLoS ONE (2009), 4(9), 7154

BACKGROUND AND AIMS: The familial Mediterranean fever (FMF) gene (MEFV) encodes pyrin, a major regulator of the inflammasome platform controlling caspase-1 activation and IL-1beta processing. Pyrin has ... [more ▼]

BACKGROUND AND AIMS: The familial Mediterranean fever (FMF) gene (MEFV) encodes pyrin, a major regulator of the inflammasome platform controlling caspase-1 activation and IL-1beta processing. Pyrin has been shown to interact with the gene product of NLRP3, NALP3/cryopyrin, also an important active member of the inflammasome. The NLRP3 region was recently reported to be associated with Crohn's disease (CD) susceptibility. We therefore sought to evaluate MEFV as an inflammatory bowel disease (IBD) susceptibility gene. METHODOLOGY AND RESULTS: MEFV colonic mucosal gene expression was significantly increased in experimental colitis mice models (TNBS p<0.0003; DSS p<0.006), in biopsies from CD (p<0.02) and severe ulcerative colitis (UC) patients (p<0.008). Comprehensive genetic screening of the MEFV region in the Belgian exploratory sample set (440 CD trios, 137 UC trios, 239 CD cases, 96 UC cases, and 107 healthy controls) identified SNPs located in the MEFV 5' haplotype block that were significantly associated with UC (rs224217; p = 0.003; A allele frequency: 56% cases, 45% controls), while no CD associations were observed. Sequencing and subsequent genotyping of variants located in this associated haplotype block identified three synonymous variants (D102D/rs224225, G138G/rs224224, A165A/rs224223) and one non-synonymous variant (R202Q/rs224222) located in MEFV exon 2 that were significantly associated with UC (rs224222: p = 0.0005; A allele frequency: 32% in cases, 23% in controls). No consistent associations were observed in additional Canadian (256 CD trios, 91 UC trios) and Scottish (495 UC, 370 controls) sample sets. We note that rs224222 showed marginal association (p = 0.012; G allele frequency: 82% in cases, 70% in controls) in the Canadian sample, but with a different risk allele. None of the NLRP3 common variants were associated with UC in the Belgian-Canadian UC samples and no significant interactions were observed between NLRP3 and MEFV that could explain the observed flip-flop of the rs224222 risk allele. CONCLUSION: The differences in association levels observed between the sample sets may be a consequence of distinct founder effects or of the relative small sample size of the cohorts evaluated in this study. However, the results suggest that common variants in the MEFV region do not contribute to CD and UC susceptibility. [less ▲]

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See detailDéveloppement d'embryons zygotiques hybrides entre un cultivar (NI637) de Phaseolus vulgaris L. et un génotype sauvage (NI108) de P. coccineus L.
Nguema Ndoutoumou, P.; Baudoin, Jean-Pierre ULg; Toussaint, André et al

in International Journal of Biology and Chemical Sciences (2009), 3(1),

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See detailAnalyse dynamique du phénomène d'auto-blocage dans les charnières de type Carpentier
Hoffait, Sébastien ULg; Bruls, Olivier ULg; Granville, D. et al

in Colloque National en Calcul des Structures, Giens, 2009 (2009)

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See detailInternational Arbitration 2009 : Belgium
Kohl, Benoît ULg; Van Houtte, Vera

in The International Comparative Legal Guide to : International Arbitration 2009 (2009)

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See detailCommon variants in the NLRP3 region contribute to Crohn's disease susceptibility.
Villani, Alexandra-Chloé; Lemire, Mathieu; Fortin, Geneviève et al

in Nature Genetics (2009), 41(1), 71-6

We used a candidate gene approach to identify a set of SNPs, located in a predicted regulatory region on chromosome 1q44 downstream of NLRP3 (previously known as CIAS1 and NALP3) that are associated with ... [more ▼]

We used a candidate gene approach to identify a set of SNPs, located in a predicted regulatory region on chromosome 1q44 downstream of NLRP3 (previously known as CIAS1 and NALP3) that are associated with Crohn's disease. The associations were consistently replicated in four sample sets from individuals of European descent. In the combined analysis of all samples (710 father-mother-child trios, 239 cases and 107 controls), these SNPs were strongly associated with risk of Crohn's disease (P(combined) = 3.49 x 10(-9), odds ratio = 1.78, confidence interval = 1.47-2.16 for rs10733113), reaching a level consistent with the stringent significance thresholds imposed by whole-genome association studies. In addition, we observed significant associations between SNPs in the associated regions and NLRP3 expression and IL-1beta production. Mutations in NLRP3 are known to be responsible for three rare autoinflammatory disorders. These results suggest that the NLRP3 region is also implicated in the susceptibility of more common inflammatory diseases such as Crohn's disease. [less ▲]

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