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See detailPrevention cardio-vasculaire: la "polypill", une solution pour vaincre l'inertie clinique et le manque d'observance?
Scheen, André ULg; Lefebvre, Pierre ULg; Kulbertus, Henri ULg

in Revue Médicale de Liège (2010), 65(5-6), 267-72

The concept of "polypill" for cardiovascular prevention was introduced in 2003 in a landmark paper of the British Medical Journal. A model based on results provided by evidence-based medicine suggested ... [more ▼]

The concept of "polypill" for cardiovascular prevention was introduced in 2003 in a landmark paper of the British Medical Journal. A model based on results provided by evidence-based medicine suggested that a "polypill", that contains a statin, three blood pressure lowering drugs (each at half standard dose), aspirin and folic acid, would result in an 80% reduction in the incidence of coronary and cerebrovascular events, while being associated with a good tolerance profile and offering a favourable cost-effectiveness ratio. The present paper aims at presenting the new advances dealing with this new paradigm in cardiovascular prevention. We will present the progresses of the "polypill" concept since 2003, the results of a first controlled clinical trial, the pharmaceutical feasibility for routine clinical use and the potential pharmaco-economical impacts of such a strategy. The "polypill" may offer a solution to avoid physician's clinical inertia and reduce patients's lack of compliance, two drawbacks in the field of cardiovascular prevention. [less ▲]

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See detailIdentification of chromosomal regions associated with segregation distortion of SSR markers and the genes controlling the low-gossypol seed & high-gossypol plant trait of Gossypium sturtianum
Benbouza, H.; Diouf, F.B.; Schefflers, J. et al

Conference (2010)

Distorted segregation of DNA markers is commonly encountered, especially in inter-specific crosses. Our main objective in this study was to identify chromosomal regions consistently associated with ... [more ▼]

Distorted segregation of DNA markers is commonly encountered, especially in inter-specific crosses. Our main objective in this study was to identify chromosomal regions consistently associated with segregation distortion in [(G. hirsutum x G. raimondii) x G. sturtianum] (HRS) hybrid. Segregation distortion skews the genotypic frequencies from their Mendelian expectations. In HRS progeny, chi square analysis (P < 0.01) showed significant skewed in all targeted linkage groups c2-c14, c3-c17, and c6-c25. Chromosomal region was regarded as being associated with skewed segregation, if three or more closely linked markers exhibited significant segregation distortion in one or more population(s). The targeted introgression regions in the tested population seem to be favourable for segregation distortion. Segregation distortion in HRS hybrid progenies differed in male and female gametes. Furthermore, the data indicated that the environment has strongly influenced the transfer of SSR markers through microspores. The consistent location of these chromosomal regions in selfed and backcross of HRS derivatives indicate probably the identification of segregation distortion regions (SDRs) in HRS hybrid. Comparison with results regarding the segregation distortion regions obtained in previous research by other authors and results we obtained regarding the absence of recombinations between BNL3436 and BNL1153 markers mapped on c6-c25 chromosome and spanned by 64 cM on the G. hirsutum map, after several generations of selfing, arise the question of the conservation of the gene order and spacing in G. sturtianum. Results showed that three SSR markers mapped on c6-c25 linkages groups were systematically transmitted in all selected progenies of the HRS tri-specific hybrid. Furthermore, the high percentages of loci with significant segregation distortion observed in this study suppose that a genetic mechanism may exist for preferential transmission of alien chromosomes segments. High heterozygosity frequencies (+/- 80%) were observed for all conserved G. sturtianum SSR markers, after several generations of backcrossing and selfing, which indicate that the cytogenetic and genetic conditions for obtaining homozygotes at high frequency are not met. [less ▲]

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See detailMagnetocaloric effect in La0.75Sr0.25MnO3 manganite
Pekala, M.; Pekala, K.; Drozd, V. et al

in Journal of Magnetism & Magnetic Materials (2010), 322(21), 3460-3463

The polycrystalline manganite La0.75Sr0.25MnO3 prepared by an alternative carbonate precipitation route reveals the rhombohedral perovskite structure. Magnetization isotherms measured up to 2 T are used ... [more ▼]

The polycrystalline manganite La0.75Sr0.25MnO3 prepared by an alternative carbonate precipitation route reveals the rhombohedral perovskite structure. Magnetization isotherms measured up to 2 T are used to determine Curie temperature of 332 K by means of Arrott plot. Maximum of magnetic entropy change is found at Curie temperature. The relative cooling power equal to 64 J/kg for 1.5 T magnetic field, is superior as compared to the manganite with the same chemical composition from the sol–gel method. [less ▲]

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See detailSoil chemical changes following 3-year legume or grass leys in west Africa
Adjolohoun, Sébastien; Bindelle, Jérôme ULg; Adandedjan, Claude et al

in Tropical Grasslands (2010), 44

The influence of 4 tropical grasses (Panicum maximum, Andropogon gayanus broad- (BL) and narrow-leaf (NL) types and Pennisetum purpureum) and 6 legumes (Aeschynomene histrix, Stylosanthes fruticosa ... [more ▼]

The influence of 4 tropical grasses (Panicum maximum, Andropogon gayanus broad- (BL) and narrow-leaf (NL) types and Pennisetum purpureum) and 6 legumes (Aeschynomene histrix, Stylosanthes fruticosa, Centrosema pubescens, Mucuna pruriens var. utilis, Cajanus cajan and Leucaena leucocephala) on fertility of the top soil in the Sudanian region of Benin over 3 years was investigated. The plants were sown without fertiliser, harvested under a cut-and-carry regime and soil changes were compared with those under a natural fallow. Soil samples were collected before the study commenced and at the end of the 3-year study. These were analysed for pH, organic C, N, available P and exchangeable cations (Ca, Mg, K and Na). N, P and K contents of aerial parts were determined to estimate the exports of these elements. For the grasses, root biomass, depth and distribution were also measured. Three years after grasses and legumes were sown, the pH under the grasses (6.6-6.7) was higher than under the legumes (6.2-6.4) and C and N concentrations had declined from the initial levels. Owing to their deep rooting systems, A. gayanus BL and P. maximum, and probably C. cajan and L. leucocephala, appeared able to recycle nutrients from deeper soil layers. While these species could be used for ley pastures in savannah regions of west Africa, maintenance fertiliser applications would be required to prevent nutrient depletion under a cut-and-carry regime. Further studies to test the efficacy of farmyard manure in providing these nutrients seem warranted. [less ▲]

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See detailPneumopathies organisées: à propos de 3 cas
Nepper, S.; Frusch, Nicolas ULg; Louis, Renaud ULg et al

in Revue Médicale de Liège (2010), 65(10), 549-55

Infiltrative lung lesions are not always linked to infectious processes or cancers. An interesting entity, the OP (Organizing Pneumonia) or COP (Cryptogenic Organizing Pneumonia)--formerly BOOP ... [more ▼]

Infiltrative lung lesions are not always linked to infectious processes or cancers. An interesting entity, the OP (Organizing Pneumonia) or COP (Cryptogenic Organizing Pneumonia)--formerly BOOP (Bronchiolitis Obliterans Organizing Pneumonia)--is discussed through observations repor. ted in this article. We provide some keys to allow the astute observer to target this often curable disease. [less ▲]

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See detailModelling climate control on cropland and grassland development using phenologically tuned variables
Horion, Stéphanie; Tychon, Bernard ULg; Cornet, Yves ULg

in Geophysical Research Abstracts (2010), 12

Many studies already investigated the impact of climate change and climate variability on vegetation at global and continental scales. Using time series of remote sensing and climate data, Nemani et al ... [more ▼]

Many studies already investigated the impact of climate change and climate variability on vegetation at global and continental scales. Using time series of remote sensing and climate data, Nemani et al. (2003) analyzed trends in Net Primary Production in relation with changes in climate and showed that, between 1982 and 1999, primary productivity increased by 6% globally in response to climate change. This study also stressed the need to take into account the spatial variability of climatic constraints to plant growth when analyzing the climate change impact on vegetation. Others authors described different phenomenon linked with climate change such as increases of seasonal NDVI amplitude and growing season duration in the Northern high latitude or changes in circumpolar photosynthetic activities. Understanding the interactions between climate and vegetation is also a key issue in our PhD research. Our objective is to identify the meteorological factors which limit the development of croplands and grasslands in relation with their geographical localization. For that purpose, we acquired 10-daily time series of the Normalized Difference Vegetation Index, NDVI, derived from SPOT-VEGETATION and 7 meteorological parameters (Tmean, Tmin, Tmax, Rain, Rad, ETP, Rain-ETP) derived from ERA40 re-analyses and the operational ECMWF (European Centre for Medium-Range Weather Forecast) atmospheric model. Cross-correlations between NDVI and each one of the meteorological parameters were analysed for a set of 25 regions over Europe and Africa: 15 agricultural regions and 10 regions covered by grassland or savannas. Unlike others studies, we did not consider the vegetation globally but we focussed on two types of vegetation: croplands and grasslands. This is quite important considering the role of phenology on the vegetation cycle and its relation with climate. Moreover the analysis was not realised using yearly estimates but using 10-daily products. In order to avoid stationarity related issue, a specific methodology was developed taking into account the phenological cycle of the vegetation under consideration. Preliminary results showed that the relation between a meteorological limiting factor, e.g. precipitation, and NDVI can not be considered as linear during the year or even during the growing season. Interactions must to be studied at a smaller time scale than the growing season in order to identify properly the limiting factors to plant growth taking into account its phenology. Moreover the main limiting factors are variable from a region to another. In our analysis we also considered the possibility of a delayed response of the vegetation or a cumulated effect of meteorological events (up to 3 months). Our methodology will be presented during the conference and results will be discussed and illustrated by some test cases. [less ▲]

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See detailDevelopment of a new genetic evaluation model for carcass quality based on crossbred performances of Piétrain boars in the Walloon Region of Belgium
Dufrasne, Marie ULg; Hammami, Hedi ULg; Jaspart, Véronique et al

Conference (2010)

In context of the development of the genetic evaluation system of Piétrain boars for crossbred performances, a genetic evaluation model was developed for the estimation of genetic merit of boars for ... [more ▼]

In context of the development of the genetic evaluation system of Piétrain boars for crossbred performances, a genetic evaluation model was developed for the estimation of genetic merit of boars for backfat thickness (BF) and meat percentage (%meat). The model developed was a random regression model using linear splines on age which knots at 175, 200 and 250 days. Variance components were estimated by restricted maximum likelihood and Gibbs sampling. Estimated heritability from 150 to 300 days increased from 0.56 to 0.75 for BF and from 0.55 to 0.69 for %meat. Genetic correlation between BF and %meat varied between -0.90 and -0.93 from 150 to 300 days. According to the study of residuals, the developed model was considered to fit well the data especially between 175 and 250 days of age. [less ▲]

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See detailDevelopment of a new crossbred based evaluation for carcass quality of Piétrain boars in the Walloon Region of Belgium
Dufrasne, Marie ULg; Hammami, Hedi ULg; Jaspart, Véronique et al

Poster (2010)

The aim of this study was to develop a genetic evaluation model to estimate the genetic merit of Piétrain boars for some carcass quality traits. These boars are now evaluated on performances recorded on ... [more ▼]

The aim of this study was to develop a genetic evaluation model to estimate the genetic merit of Piétrain boars for some carcass quality traits. These boars are now evaluated on performances recorded on their crossbred progeny fattened in a central test station. Data provided by the on-farm performance recording system were utilized in this study. Traits analysed were backfat thickness (BF) and lean meat percentage (%meat). The data file contains 60 546 records measured on pigs between 150 and 300 days of age. Model developed was a multitrait animal model. Fixed effects were sex, contemporary groups and heterosis, modeled as regression on heterozygosity. Random effects were additive genetic and permanent environment, modeled by random regressions using linear splines, and residual. Variance components were estimated by restricted maximum likelihood (REML) method on random samples of the total dataset and then confirmed by a Gibbs sampling algorithm on the total dataset. Fit of the model was tested by computing residuals from a BLUP (Best Linear Unbiased Prediction) evaluation. BF and %meat have a high heritability that increase with age. These two traits are also highly genetically correlated. Mean residuals are not significantly different from zero for both traits. Given that BF and %meat had high heritability, genetic improvement of carcass quality is possible by selection on these two traits. Like residuals are close to zero for both traits, it seems that model developed explain a great proportion the variance in each traits. [less ▲]

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See detailDevelopment of a new crossbred based evaluation for carcass quality of Piétrain boars in the Walloon Region of Belgium
Dufrasne, Marie ULg; Hammami, Hedi ULg; Jaspart, Véronique et al

in Book of Abstract of the 61st Annual Meeting of the European Association for Animal Production (2010)

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See detailOntology-based approaches for improving the interoperability between 3D urban models
Metral, Claudine; Billen, Roland ULg; Cutting-Decelle, Anne-Françoise et al

in FormaMente (2010), 1-2(V), 85-111

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See detailA new case of consensual decision: collective movement in earthworms
Zirbes, Lara ULg; Deneubourg, Jean-Louis; Brostaux, Yves ULg et al

in Ethology (2010), 115

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See detailClinical characteristics and therapeutic responses in patients with Germ-line AIP mutations and pituitary adenomas : An international collaborative study
Daly, Adrian ULg; Tichomirowa, Maria A.; Petrossians, Patrick ULg et al

in Journal of Clinical Endocrinology and Metabolism (2010), 95(11),

Context: AIP mutations (AIPmut) give rise to a pituitary adenoma predisposition that occurs in familial isolated pituitary adenomas and less often in sporadic cases. The clinical and therapeutic features ... [more ▼]

Context: AIP mutations (AIPmut) give rise to a pituitary adenoma predisposition that occurs in familial isolated pituitary adenomas and less often in sporadic cases. The clinical and therapeutic features of AIPmut-associated pituitary adenomas have not been studied comprehensively. <br />Objective: The objective of the study was to assess clinical/therapeutic characteristics of AIPmut pituitary adenomas. <br />Design: This study was an international, multicenter, retrospective case collection/database analysis. <br />Setting: The study was conducted at 36 tertiary referral endocrine and clinical genetics departments. <br />Patients: Patients included 96 patients with germline AIPmut and pituitary adenomas and 232 matched AIPmut-negative acromegaly controls. <br />Results: The AIPmut population was predominantly young and male (63.5%); first symptoms occurred as children/adolescents in 50%. At diagnosis, most tumors were macroadenomas (93.3%); extension and invasion was common. Somatotropinomas comprised 78.1% of the cohort; there were also prolactinomas (n = 13), nonsecreting adenomas (n = 7), and a TSH-secreting adenoma. AIPmut somatotropinomas were larger (P = 0.00026), with higher GH levels (P = 0.00068), more frequent extension (P = 0.018) and prolactin cosecretion (P = 0.00023), and occurred 2 decades before controls (P < 0.000001). Gigantism was more common in the AIPmut group (P < 0.000001). AIPmut somatotropinoma patients underwent more surgical interventions (P = 0.00069) and had lower decreases in GH (P = 0.00037) and IGF-I (P = 0.028) and less tumor shrinkage with somatostatin analogs (P < 0.00001) vs. controls. AIPmut prolactinomas occurred generally in young males and frequently required surgery or radiotherapy. <br />Conclusions: AIPmut pituitary adenomas have clinical features that may negatively impact treatment efficacy. Predisposition for aggressive disease in young patients, often in a familial setting, suggests that earlier diagnosis of AIPmut pituitary adenomas may have clinical utility. [less ▲]

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See detailOptimisation methods for advanced design of aircraft panels: a comparison
Colson, Benoit; Bruyneel, Michaël ULg; Grihon, Stéphane et al

in Optimization & Engineering (2010), 11

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See detailFormation of Stripelike Flux Patterns Obtained by Freezing Kinematic Vortices in a Superconducting Pb Film
Silhanek, Alejandro ULg; Milosevic, M. V.; Kramer, R. B. G. et al

in Physical Review Letters (2010), 104(1),

We demonstrate experimentally and theoretically that the dissipative state of superconducting samples with a periodic array of holes at high current densities consists of flux rivers resulting from a ... [more ▼]

We demonstrate experimentally and theoretically that the dissipative state of superconducting samples with a periodic array of holes at high current densities consists of flux rivers resulting from a short-range attractive interaction between vortices. This dynamically induced vortex-vortex attraction results from the migration of quasiparticles out of the vortex core (kinematic vortices). We have directly visualized the formation of vortex chains by scanning Hall probe microscopy after freezing the dynamic state by a field cooling procedure at a constant bias current. Similar experiments carried out in a sample without holes show no hint of flux river formation. We shed light on this nonequilibrium phenomena modeled by time-dependent Ginzburg-Landau simulations. [less ▲]

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See detailQui est l'ange ? Narration, écriture et fiction dans trois poèmes majeurs de Cocteau
Purnelle, Gérald ULg

in La Revue des Lettres modernes, Série Jean Cocteau (2010), 6

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See detailWater dynamics in the soil-plant continuum: which features regulate the uptake?
Lobet, Guillaume ULg; Javaux, M.; Pagès, L. et al

Poster (2010)

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See detailThe 3-D extent of the Io UV footprint on Jupiter
Bonfond, Bertrand ULg

in Journal of Geophysical Research. Space Physics (2010), 115

The Io footprint (IFP) is the auroral signature of the electromagnetic interaction between Io and Jupiter's magnetosphere. It consists of several spots followed by an extended tail, which are located ... [more ▼]

The Io footprint (IFP) is the auroral signature of the electromagnetic interaction between Io and Jupiter's magnetosphere. It consists of several spots followed by an extended tail, which are located close to the feet of the magnetic field lines connecting Io to Jupiter. The size of the main spot is a controversial issue, and previously published values range from ~400 to ~8000 km. However, this question is crucial to understand the processes at play, since this quantity is expected to reflect the size of the interaction region at Io. The present study provides estimates of the size of the Io footprint on a much larger image sample than before, paying a particular attention to the differentiation of the spots and to their 3-D structure. The length of the Main Alfven Wing (MAW) spot and the length of the trans-hemispheric electron beam (TEB) spot along the footpath are similar to 850 km, while their width perpendicular to the footpath is < 200 km. Larger lengths are sometimes observed, but these configurations may be attributed to the overlaps of the different spots. The spot lengths are larger than the projected diameter of Io along unperturbed magnetic field lines, which is consistent with recent simulations. The narrowness of the IFP will need to be carefully accounted for in future studies of its brightness. Additionally, the peak altitudes of the MAW and the TEB spot are as high as 900 and 700 km, respectively, which seem to confirm their different origins. [less ▲]

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