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See detailRadiation-curing binders and a process for their preparation
Greszta-Franz, Dorota; Fischer, Wolfgang; Weikard, Jan et al

Patent (2006)

The invention relates to a process for preparing binders which contain 1) allophanate groups, 2) groups that react with ethylenically unsaturated compounds with polymerization on exposure to actinic ... [more ▼]

The invention relates to a process for preparing binders which contain 1) allophanate groups, 2) groups that react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation (radiation-curing group s) and 3) optionally NCO-reactive groups, by reacting at temperatures .ltoreq. 130.degree.C A) one or more NCO-functional compounds containing uretdione groups wit h B) one or more compounds that contain isocyanate-reactive groups and groups that react with ethylenically unsaturated compounds with polymerization on exposure to actinic radiation (radiation-curing groups), and then C) with one or more saturated, hydroxyl-containing compounds other than B ), at least one of these compounds having an OH functionality of .gtoreq. 2, in the presence of D) a catalyst containing one or more zinc compounds, the reaction with compounds C) taking place at least proportionally with the formation of allophanate groups. The present invention also relates to the binders obtained by the process of the invention. [less ▲]

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See detailLow viscosity allophanates containing actinically curable groups
Detrembleur, Christophe ULg; Mundstock, Holger; Greszta-Franz, Dorota et al

Patent (2006)

The present invention relates to a process for preparing radiation-curing binders containing allophanate groups by reacting at temperatures of .ltoreq.130.degree.C A) one or more compounds containing ... [more ▼]

The present invention relates to a process for preparing radiation-curing binders containing allophanate groups by reacting at temperatures of .ltoreq.130.degree.C A) one or more compounds containing uretdione groups with B) one or more OH-functional compounds which contain groups which react , with polymerization, with ethylenically unsaturated compounds on exposure to actinic radiation (radiation-curing groups), C) optionally NCO-reactive compounds other than B), in the presence of D) a catalyst containing at least one zinc compound, to form allophanate groups by opening the uretdione ring. The present invention also relates to the binders obtained by the process of the invention and to coating compositions containing these binders. [less ▲]

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See detailOn the Use of Automata-based Techniques in Symbolic Model Checking: invited address
Legay, Axel; Wolper, Pierre ULg

in Electronic Notes in Theoretical Computer Science (2006, March 09), 150(1), 3-8

Checking infinite-state systems is frequently done by encoding infinite sets of states as regular languages. Computing such a regular representation of, say, the reachable set of states of a system ... [more ▼]

Checking infinite-state systems is frequently done by encoding infinite sets of states as regular languages. Computing such a regular representation of, say, the reachable set of states of a system requires acceleration techniques that can finitely compute the effect of an unbounded number of transitions. Among the acceleration techniques that have been proposed, one finds both specific and generic techniques. Specific techniques exploit the particular type of system being analyzed, e.g. a system manipulating queues or integers, whereas generic techniques only assume that the transition relation is represented by a finite-state transducer, which has to be iterated. In this paper, we survey two generic techniques that have been presented in [B. Boigelot and A. Legay and P. Wolper, Iterating Transducers in the Large, Proc. 15th Int. Conf. on Computer Aided Verification, Boulder, USA, Lecture Notes in Computer Science, volume 2725, year 2003, pages 223–235] and [B. Boigelot and A. Legay and P. Wolper, Omega-Regular Model Checking, Proc. 10th Int. Conf. on Tools and and Algorithms for the Construction and Analysis of Systems, Barcelona, Spain, Lecture Notes in Computer Science, volume 2988, year 2004, pages 561–575]. Those techniques build on earlier work, but exploits a number of new conceptual and algorithmic ideas, often induced with the help of experiments, that give it a broad scope, as well as good performance. [less ▲]

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See detailMatrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in the respiratory tract: Potential implications in asthma and other lung diseases
Guéders, Maud ULg; Foidart, Jean-Michel ULg; Noël, Agnès ULg et al

in European Journal of Pharmacology (2006), 533(1-3), 133-144

In healthy lung, Matrix Metalloproteinases (MMPs) and their physiological inhibitors, tissue inhibitors of matrix metalloproteinases (TIMPs), are produced in the respiratory tract by a panel of different ... [more ▼]

In healthy lung, Matrix Metalloproteinases (MMPs) and their physiological inhibitors, tissue inhibitors of matrix metalloproteinases (TIMPs), are produced in the respiratory tract by a panel of different structural cells. These activities are mandatory for many physiological processes including development, wound healing and cell trafficking. Deregulation of proteolytic-antiproteolytic network and inappropriate secretion of various MMPs by stimulated structural or inflammatory cells is thought to take part to pathophysiology of numerous lung diseases including asthma, chronic obstructive pulmonary disease (COPD), lung fibrosis and lung cancer. Cytokines and growth factors are involved in these inflammatory processes and some of those mediators interact directly with MMPs and TIMPs leading either to a regulation of their expression or changes in their biological activities by proteolytic cleavage. In turn, cytokines and growth factors modulate secretion of MMPs establishing a complex network of reciprocal interactions. Every MMP seem to play a rather specific role and some variations of their expression are observed in different lung diseases. The precise role of these enzymes and their inhibitors is now studied in depth as they could represent relevant therapeutic targets for many diseases. Indeed, MMP inhibition can lead either to a decrease of the intensity of a pathological process or, in the contrary for some of them, to an increase of disease severity. In this review, we focus on the role played by MMPs and TIMPs in asthma and we provide an overview of their potential roles in COPD, lung fibrosis and lung cancer, with a special emphasis on loops including MMPs and cytokines and growth factors relevant in these diseases. [less ▲]

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See detailLo specchio secondario adattivo dell’LBT: calibrazione del prototipo P45
Ricci, Davide ULg

Master's dissertation (2006)

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See detailHigh precision determination of the atmospheric parameters and abundances of the COROT main targets
Gillon, Michaël ULg; Magain, Pierre ULg

in Astronomy and Astrophysics (2006), 448

Context: .One of the main goals of the COROT mission is to get precise photometric observations of selected bright stars in order to allow the modelling of their interior through asteroseismology. However ... [more ▼]

Context: .One of the main goals of the COROT mission is to get precise photometric observations of selected bright stars in order to allow the modelling of their interior through asteroseismology. However, in order to interpret the asteroseismological data, the effective temperature, surface gravity, and chemical composition of the stars must be known with sufficient accuracy.Aims.To carry out this task, we have developed a spectroscopic method called APASS (Atmospheric Parameters and Abundances from Synthetic Spectra) which allows precise analysis of stars with a moderate to high rotational velocity, which is the case for most primary COROT targets.Methods.Our method is based on synthetic spectra in which individual lines are replaced by analysis units (isolated lines or line blends, depending on the crowding of the spectral region and on the rotational broadening). It works differentially with respect to the Sun and allows the atmospheric parameters and chemical abundances to be determined by considering analysis units with different sensitivities to these various parameters.Results.Using high signal-to-noise spectra and the APASS method, we determined the atmospheric parameters and chemical abundances of 13 primary COROT targets. Our results agree well with those obtained by Bruntt using his software VWA and with those obtained with the software TEMPLOGG. However, in both cases, our error bars are significantly smaller than those of other methods. Our effective temperatures are also in excellent agreement with those obtained with the IR photometry method. For five stars with relatively low rotational velocity, we also performed an analysis with a classical equivalent-width method to test agreement with APASS results. We show that equivalent-width measurements by Gaussian or Voigt profile-fitting are sensitive to the rotational broadening, leading to systematic errors whenever the projected rotation velocity is non-negligible. The APASS method appears superior in all cases and should thus be preferred. [less ▲]

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See detailPerformance study of ground-based infrared Bracewell interferometers. Application to the detection of exozodiacal dust disks with GENIE
Absil, Olivier ULg; den Hartog, R.; Gondoin, P. et al

in Astronomy and Astrophysics (2006), 448

Nulling interferometry, a powerful technique for high-resolution imaging of the close neighbourhood of bright astrophysical objets, is currently considered for future space missions such as Darwin or the ... [more ▼]

Nulling interferometry, a powerful technique for high-resolution imaging of the close neighbourhood of bright astrophysical objets, is currently considered for future space missions such as Darwin or the Terrestrial Planet Finder Interferometer (TPF-I), both aiming at Earth-like planet detection and characterization. Ground-based nulling interferometers are being studied for both technology demonstration and scientific preparation of the Darwin/TPF-I missions through a systematic survey of circumstellar dust disks around nearby stars. In this paper, we investigate the influence of atmospheric turbulence on the performance of ground-based nulling instruments, and deduce the major design guidelines for such instruments. End-to-end numerical simulations allow us to estimate the performance of the main subsystems and thereby the actual sensitivity of the nuller to faint exozodiacal disks. Particular attention is also given to the important question of stellar leakage calibration. This study is illustrated in the context of GENIE, the Ground-based European Nulling Interferometer Experiment, to be installed at the VLTI and working in the L' band. We estimate that this instrument will detect exozodiacal clouds as faint as about 50 times the Solar zodiacal cloud, thereby placing strong constraints on the acceptable targets for Darwin/TPF-I. [less ▲]

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See detailL'astronomie dans le monde
Manfroid, Jean ULg

Article for general public (2006)

Des Troyens de glace; Plus grande que Pluton; Deux méga-systèmes solaires; C'est parti; Un accélérateur de particules au centre de notre Galaxie; Surprenant champ magnétique d'une naine rouge; Fuyards ... [more ▼]

Des Troyens de glace; Plus grande que Pluton; Deux méga-systèmes solaires; C'est parti; Un accélérateur de particules au centre de notre Galaxie; Surprenant champ magnétique d'une naine rouge; Fuyards; Décimation de l'amas globulaire M12; Silicates et galaxies lointaines; Matière noire; GRB060218; L'autre plan d'Andromède [less ▲]

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See detailAnimal evolution — A fully-resolved phylogenomic tree argues against the Cambrian explosion hypothesis
Philippe, Hervé; Brinkmann, Henner; Baurain, Denis ULg

Poster (2006, March)

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See detailPaysage tactile? Pour le réveil des sens finalisé à une meilleure compréhension de nos milieux de vie.
Occhiuto, Rita ULg

in Cahiers de l'Urbanisme (Les) (2006), 58

The landscape, connected with human and natural interactions, remains a worn-out term, referring both to the subject and the object. It conveys an aesthetic value expressing the dominance of sight. It ... [more ▼]

The landscape, connected with human and natural interactions, remains a worn-out term, referring both to the subject and the object. It conveys an aesthetic value expressing the dominance of sight. It moves us away from the body of the landscape (water, air and soil) by the inibition of sensorial capacities. Sight and hearing override the other senses. The author recalls that touch is a powerful means of sensorial exploration of space which makes it possible for us to renew relationships with the environment and rediscover the meaning of itinerary and voyage. [less ▲]

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See detailChapter in Basin report for Meuse case on updated research questions and detailed research plan for month 25-42, including a new work package description
Joziasse, Jan; Vink, Jos; Kessels, Eric et al

Report (2006)

The work plan for the period Month 25 – 42 is presented in this deliverable. The activities foreseen are a logical follow-up of the past activities, so no major updates compared to the previous ... [more ▼]

The work plan for the period Month 25 – 42 is presented in this deliverable. The activities foreseen are a logical follow-up of the past activities, so no major updates compared to the previous description of work (covering months 13 – 24) was needed. [less ▲]

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See detailAnemie et insuffisance cardiaque
Nellessen, Eric ULg; Pierard, Luc ULg

in Revue Médicale de Liège (2006), 61(3), 154-8

The prevalence of heart failure is increasing. Anemia is often present, particularly in severe cases. The Fick equation illustrates the relationship between anemia and heart failure. The concepts of ... [more ▼]

The prevalence of heart failure is increasing. Anemia is often present, particularly in severe cases. The Fick equation illustrates the relationship between anemia and heart failure. The concepts of cardiorenal syndrome and erythropoietin resistance are parts of the physiopathology. Anemia is associated with a bad prognosis in heart failure. Nevertheless, it is too early to know precisely whether anemia represents a simple marker of severity or if specific treatment, especially with erythropoietin, is useful in terms of morbidity and mortality. Current guidelines recommend the correction of secondary causes when anemia is present in a heart failure patient. [less ▲]

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See detailPrevalence of the metabolic syndrome in patients with schizophrenia treated with antipsychotic medication
De Hert, Marc A.; van Winkel, Ruud; Van Eyck, Dominique et al

in Schizophrenia Research (2006), 83(1), 87-93

The presence of the metabolic syndrome is an important risk factor for cardiovascular disease and diabetes. There are limited data on the prevalence of the metabolic syndrome in European patients ... [more ▼]

The presence of the metabolic syndrome is an important risk factor for cardiovascular disease and diabetes. There are limited data on the prevalence of the metabolic syndrome in European patients suffering from schizophrenia. Methods: All consecutive patients with schizophrenia at our university psychiatric hospital and affiliate services were entered in an extensive prospective metabolic study including an oral glucose tolerance test. The prevalence of the metabolic syndrome was assessed based on the National Cholesterol Education Program criteria (NCEP, Adult Treatment Protocol, ATP-III), adapted ATP-III criteria using a fasting glucose threshold of 100 mg/dl (AHA) and on the recently proposed criteria from the International Diabetes Federation (IDF). Results: The analysis of 430 patients showed a prevalence of the metabolic syndrome of 28.4% (ATP-III), 32.3% (ATP-III A) and 36% (IDF), respectively. The prevalence of the metabolic syndrome in our sample of patients with schizophrenia is at least twice as high compared to an age-adjusted community sample in Belgium. Conclusion: The metabolic syndrome is highly prevalent among treated patients with schizophrenia. It represents an important risk for cardiovascular and metabolic disorders. Assessment of the presence and monitoring of the associated risks of the metabolic syndrome should be part of the clinical management of patients treated with antipsychotics. (c) 2006 Elsevier B.V. All rights reserved. [less ▲]

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See detailAlpha-fetoprotein controls female fertility and prenatal development of the gonadotropin-releasing hormone pathway through an antiestrogenic action
De Mees, Christelle; Laes, Jean-François; Bakker, Julie ULg et al

in Molecular and Cellular Biology (2006), 26(5), 2012-2018

It has been shown previously that female mice homozygous for an alpha-fetoprotein (AFP) null allele are sterile as a result of anovulation, probably due to a defect in the hypothalamic-pituitary axis ... [more ▼]

It has been shown previously that female mice homozygous for an alpha-fetoprotein (AFP) null allele are sterile as a result of anovulation, probably due to a defect in the hypothalamic-pituitary axis. Here we show that these female mice exhibit specific anomalies in the expression of numerous genes in the pituitary, including genes involved in the gonadotropin-releasing hormone pathway, which are underexpressed. In the hypothalamus, the gonadotropin-releasing hormone gene, Gnrh1, was also found to be down-regulated. However, pituitary gene expression could be normalized and fertility could be rescued by blocking prenatal estrogen synthesis using an aromatase inhibitor. These results show that AFP protects the developing female brain from the adverse effects of prenatal estrogen exposure and clarify a long-running debate on the role of this fetal protein in brain sexual differentiation. [less ▲]

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See detailEvaluation of BM-573, a novel TXA(2) synthase inhibitor and receptor antagonist, in a porcine model of myocardial ischemia-reperfusion
Kolh, Philippe ULg; Rolin, S.; Tchana-Sato, Vincent ULg et al

in Prostaglandins & Other Lipid Mediators (2006), 79(1-2), 53-73

Aims: To investigate whether BM-573 (N-tert-butyl-N'-[2-(4'-methylphenylam\ino)-5-nitro-benzenesulfonyl]urea), an original combined thromboxane A(2) synthase inhibitor and receptor antagonist, prevents ... [more ▼]

Aims: To investigate whether BM-573 (N-tert-butyl-N'-[2-(4'-methylphenylam\ino)-5-nitro-benzenesulfonyl]urea), an original combined thromboxane A(2) synthase inhibitor and receptor antagonist, prevents reperfusion injury in acutely ischemic pigs. Methods: Twelve animals were randomly divided in two groups: a control group (n = 6) intravenously infused with vehicle, and a BM-573-treated group (n = 6) infused with BM-573 (10 mg kg(-1) h(-1)). In both groups, the left anterior descending (LAD) coronary artery was Occluded for 60 min and reperfused for 240 min. Either vehicle or BM-573 was infused 30 min before LAD occlusion and throughout the experiment. Platelet aggregation induced by arachidonic acid ex vivo measured was prevented by BM-573. Results: In both groups, LAD occlusion decreased cardiac output, ejection fraction, slope of stroke work-end-diastolic volume relationship, and induced end-systolic pressure-volume relationship (ESPVR) rightward shift, while left ventricular afterload increased. Ventriculo-arterial coupling and mechanical efficiency decreased. In both groups, reperfusion further decreased cardiac output and ejection fraction, while ESPVR displayed a further rightward shift. Ventriculo-arterial coupling and mechanical efficiency remained impaired. Area at risk, evidenced with Evans blue, was 33.2 +/- 3.4% of the LV mass (LVM) in both groups, and mean infarct size, revealed by triphenyltetrazolium chloride (TTC), was 27.3 +/- 2.6% of the LVM in the BM-573-treated group (NS). Histological examination and immunohistochemical identification of desmin revealed necrosis in the anteroseptal region similar in both groups, while myocardial ATP dosages and electron microscopy also showed that BM-573 had no cardioprotective effect. Conclusions: These data suggest that BM-573 failed to prevent reperfusion injury in acutely ischemic pigs. (C) 2005 Elsevier Inc. All rights reserved. [less ▲]

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See detailles énergies renouvelables
Boniver, Véronique ULg; Denis, Olivier; Derzelle, Christophe et al

Report (2006)

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