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See detailPour professionnaliser le métier d’enseignant du supérieur : le master complémentaire Form@sup
Poumay, Marianne ULg

in Revue Internationale des Technologies en Pédagogie Universitaire (2006), 3(1-2), 1-13

The article presents the Form@sup postgraduate degree, a one year training (60 ECTS) organized at the University of Liège, Belgium. The training aims at helping colleagues modify their practice, through a ... [more ▼]

The article presents the Form@sup postgraduate degree, a one year training (60 ECTS) organized at the University of Liège, Belgium. The training aims at helping colleagues modify their practice, through a revisiting of the courses they have in charge. They perform a reflection-intervention inspired by the Scholarship of Teaching and Learning movement. Form@sup is described in its objectives, its tools, its principles, its models and methods. We then propose some participants’ comments before ending with a brief presentation of the changes that will be introduced in the next few years. [less ▲]

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See detailEstablishment of stable human fibroblast cell lines constitutively expressing active Rho-GTPases.
Servotte, S.; Zhang, Z.; Lambert, Charles ULg et al

in Protoplasma (2006), 229(2-4), 215-20

Small GTP-binding proteins of the Rho family (RhoA, Cdc42, Rac1) regulate the organisation and the turnover of the cell's cytoskeleton and adhesion structures. A significant function of these cellular ... [more ▼]

Small GTP-binding proteins of the Rho family (RhoA, Cdc42, Rac1) regulate the organisation and the turnover of the cell's cytoskeleton and adhesion structures. A significant function of these cellular structures is to translate and counterbalance forces applied to, or generated by, cells in order to maintain homeostasis and control cell movement. We therefore hypothesised that Rho-GTPases are directly involved in cellular gravity perception and may participate in the alterations induced in microgravity. To define an adequate cellular model allowing to investigate this issue, we have established stable cell lines constitutively expressing active forms of either RhoA, Cdc42, or Rac1. The three cell lines differ by morphology and by their ability to form filopodia, lamellipodia, and bundles of actin stress fibers. Overexpression of the active form of either RhoA, Cdc42, or Rac1 is compatible with cell viability and does not affect cell population doubling time. Thus, our series of mutant cells appear well suited to gain further knowledge on the molecular mechanisms of cellular gravity perception. [less ▲]

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See detailManuel de formation à la gestion du stress et à la communication avec des patients cancéreux et leurs proches
Etienne, Anne-Marie ULg; Bragard, Isabelle ULg; Libert, Yves et al

in CHASSEIGNE, Gérard (Ed.) Stress, santé, société (2006)

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See detailLes besoins psychosociaux et le soutien apporté aux patients atteints d'un cancer : une étude nationale belge
Libert, Yves; Merckaert, Isabelle; Etienne, Anne-Marie ULg et al

in Oncologie (2006), (8), 465-476

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See detailA full heteroscedastic one-way error components model: Pseudo-maximum likelihood estimation and specification testing
Lejeune, Bernard ULg

in Baltagi, Badi H. (Ed.) Panel Data Econometrics: Theoretical Contributions and Empirical Applications (2006)

This paper proposes an extension of the standard one-way error components model allowing for heteroscedasticity in both the individual-specific and the general error terms, as well as for unbalanced panel ... [more ▼]

This paper proposes an extension of the standard one-way error components model allowing for heteroscedasticity in both the individual-specific and the general error terms, as well as for unbalanced panel. On the grounds of its computational convenience, its potential efficiency, its robustness to non-normality and its robustness to possible misspecification of the assumed scedastic structure of the data, we argue for estimating this model by Gaussian pseudo-maximum likelihood of order two. Further, we review how, taking advantage of the powerful m-testing framework, the correct specification of the prominent aspects of the model may be tested. We survey potentially useful nested, non-nested, Hausman and information matrix type diagnostic tests of both the mean and the variance specification of the model. Finally, we illustrate the usefulness of our proposed model and estimation and diagnostic testing procedures through an empirical example. [less ▲]

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See detailEfficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study.
Scheen, André ULg; Finer, Nick; Hollander, Priscilla et al

in Lancet (2006), 368(9548), 1660-72

BACKGROUND: Rimonabant, a selective cannabinoid type 1 receptor blocker, reduces bodyweight and improves cardiovascular and metabolic risk factors in non-diabetic overweight or obese patients. The aim of ... [more ▼]

BACKGROUND: Rimonabant, a selective cannabinoid type 1 receptor blocker, reduces bodyweight and improves cardiovascular and metabolic risk factors in non-diabetic overweight or obese patients. The aim of the RIO-Diabetes trial was to assess the efficacy and safety of rimonabant in overweight or obese patients with type 2 diabetes that was inadequately controlled by metformin or sulphonylureas. METHODS: 1047 overweight or obese type 2 diabetes patients (body-mass index 27-40 kg/m2) with a haemoglobin A1c (HbA1c) concentration of 6.5-10.0% (mean 7.3% [SD 0.9] at baseline) already on metformin or sulphonylurea monotherapy were given a mild hypocaloric diet and advice for increased physical activity, and randomly assigned placebo (n=348), 5 mg/day rimonabant (360) or 20 mg/day rimonabant (339) for 1 year. Two individuals in the 5 mg/day group did not receive double-blind treatment and were thus not included in the final analysis. The primary endpoint was weight change from baseline after 1 year of treatment. Analyses were done on an intention-to-treat basis. This trial is registered at ClinicalTrials.gov, number NCT00029848. FINDINGS: 692 patients completed the 1 year follow-up; numbers in each group after 1 year were much the same. Weight loss was significantly greater after 1 year in both rimonabant groups than in the placebo group (placebo: -1.4 kg [SD 3.6]; 5 mg/day: -2.3 kg [4.2], p=0.01 vs placebo; 20 mg/day: -5.3 kg [5.2], p<0.0001 vs placebo). Rimonabant was generally well tolerated. The incidence of adverse events that led to discontinuation was slightly greater in the 20 mg/day rimonabant group, mainly due to depressed mood disorders, nausea, and dizziness. INTERPRETATION: These data indicate that 20 mg/day rimonabant, in combination with diet and exercise, can produce a clinically meaningful reduction in bodyweight and improve HbA1c and a number of cardiovascular and metabolic risk factors in overweight or obese patients with type 2 diabetes inadequately controlled by metformin or sulphonylureas. [less ▲]

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See detailEffets de la duree du diabete de type 1 sur la pression arterielle pulse: etude transversale controlee.
Philips, Jean-Christophe ULg; Marchand, Monique ULg; Weekers, Laurent ULg et al

in Archives des Maladies du Coeur et des Vaisseaux (2006), 99(7-8), 683-6

Diabetes mellitus and arterial pulse pressure (PP) are two independent cardiovascular risk factors. This cross-sectional study investigated the influence of diabetes duration on PP in type 1 diabetic ... [more ▼]

Diabetes mellitus and arterial pulse pressure (PP) are two independent cardiovascular risk factors. This cross-sectional study investigated the influence of diabetes duration on PP in type 1 diabetic patients without any cardiovascular disease. PP was measured continuously during 3 minutes (active orthostatic test: 1 min standing--1 min squatting--1 min standing) using a fingertip plethysmograph (Finapres) in 159 type 1 diabetic patients aged 20-60 yrs. They were divided into 4 groups according to diabetes duration: (1) G1 : <10 yrs (n=39); G2: 11-20 yrs (n=45); G3: 21-30 yrs (n=57); and G4: >30 yrs (n=18). In order to separate the effects of age from the effects of diabetes duration, diabetic patients were compared to age- and sex-matched non diabetic controls. PP (expressed in mmHg; mean +/- SD) was higher in men than in women in both diabetic (58 +/- 15 vs. 50 +/- 14; p = 0.001) and non diabetic subjects (55 +/- 14 vs. 47 +/- 12; p = 0.001). Overall PP was higher in diabetic than in non diabetic individuals (54 +/- 15 vs. 50 +/- 13; p = 0.025). PP progressively increased according to diabetes duration: 47 +/- 16 vs. 51 +/- 13 vs. 59 +/- 14 vs. 62 +/- 12, from G1 to G4 respectively; p < 0.0001. Such an increase was not observed in age-matched non diabetic subjects: 50 +/- 11 vs. 52 +/- 12 vs. 49 +/- 14 vs. 52 +/- 18, from G1 to G4, respectively; NS. PP was higher in squatting than in standing position in non diabetic subjects (52 +/- 16 vs. 47 +/- 13; p < 0.0001) and even more in diabetic patients (59 +/- 17 vs. 50 +/- 14; p < 0.0001). Overall, PP difference between diabetic and non diabetic individuals was not significant in standing position (50 +/- 14 vs. 47 +/- 13; NS) although it became highly significant in squatting position (59 +/- 17 vs. 52 +/- 16; p = 0.0005). The squatting-standing difference in PP markedly increased with diabetes duration: 69 +/- 14 during squatting vs. 50 +/- 18 during standing in G4 compared to respectively 50 +/- 17 vs. 44 +/- 15 in G1 diabetic patients. Finally, PP was similar (NS) in diabetic patients with HbA1c < 8% (54 +/- 14) or > or =8% (55 +/- 16), with (57 +/- 17) or without (54 +/- 14) microalbuminuria, treated (56 +/- 14) or not (54 +/- 15) by inhibitors of the renin-angiotensin system. In conclusion, PP progressively increased with the duration of type 1 diabetes, independently of age. Such increase was more marked in squatting than in standing position. The role of such PP rise in the increased cardiovascular risk of patients with type 1 diabetes, although suspected in the recent EURODIAB Prospective Complications Study, deserves further investigation. [less ▲]

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See detailAspirin and clopidogrel resistance in patients with diabetes mellitus.
Scheen, André ULg; Legrand, Delphine ULg

in European Heart Journal (2006), 27(23), 29002900-1

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See detailLe rimonabant ameliore le profit de risque cardio-metabolique chez le sujet obese ou en surpoids: synthese des etudes "RIO".
Scheen, André ULg; Van Gaal, L. G.; Despres, J. P. et al

in Revue Médicale Suisse (2006), 2(76), 1916-23

RIO (Rimonabant In Obesity and related disorders) is a large phase 3 programme (>6600 patients) evaluating the efficacy and safety of rimonabant (5 or 20 mg/day), a CBI receptor antagonist of ... [more ▼]

RIO (Rimonabant In Obesity and related disorders) is a large phase 3 programme (>6600 patients) evaluating the efficacy and safety of rimonabant (5 or 20 mg/day), a CBI receptor antagonist of endocannabinoid system, in obese or overweight patients with or without comorbidities (RIO-Europe and RIO-North America), with untreated dyslipidaemia (RIO-Lipids) or with type 2 diabetes treated with metformin or sulfonylurea (RIO-Diabetes). Compared to placebo, rimonabant 20 mg/day consistently increases weight loss, reduces waist circumference, increases HDL cholesterol, lowers triglyceride levels, diminishes insulin resistance, and reduces the prevalence of metabolic syndrome. Almost half of the metabolic effects, including adiponectin increase, occur beyond weight loss, suggesting a direct peripheral effect of rimonabant. [less ▲]

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See detailVaccinia virus strain Western Reserve protein B14 is an intracellular virulence factor.
Chen, Ron A-J; Jacobs, Nathalie ULg; Smith, Geoffrey L

in Journal of General Virology (The) (2006), 87(Pt 6), 1451-8

A characterization of the B14R gene from Vaccinia virus (VACV) strain Western Reserve (WR) is presented. Computational analyses of the B14R gene indicated high conservation in orthopoxviruses but no ... [more ▼]

A characterization of the B14R gene from Vaccinia virus (VACV) strain Western Reserve (WR) is presented. Computational analyses of the B14R gene indicated high conservation in orthopoxviruses but no orthologues outside the Poxviridae. To characterize the B14 protein, the B14R gene was expressed in Escherichia coli and recombinant protein was purified and used to generate a rabbit polyclonal antiserum. This antiserum recognized a 15 kDa cytoplasmic protein in mammalian cells that were transfected with the B14R gene or infected with VACV WR, but not from cells infected with a VACV mutant (vdeltaB14) from which the B14R gene was deleted. Compared to wild-type and revertant virus controls, vdeltaB14 had normal growth kinetics in cell culture. The virulence of vdeltaB14 was assessed in two in vivo models. Mice infected intranasally with vdeltaB14 had similar weight loss compared to the controls, but in C57BL/6 mice infected intradermally vdeltaB14 induced a smaller lesion size compared with controls. Moreover, intradermal infection with vdeltaB14 caused an increased infiltration of cells into the infected lesion despite the smaller lesion size. Therefore, B14 is an intracellular protein that is non-essential for virus replication in cell culture but contributes to virus virulence in vivo and affects the host response to infection. [less ▲]

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See detailIntradermal immune response after infection with Vaccinia virus.
Jacobs, Nathalie ULg; Chen, Ron A-J; Gubser, Caroline et al

in Journal of General Virology (The) (2006), 87(Pt 5), 1157-61

Although Vaccinia virus (VACV) was used to eradicate smallpox by dermal vaccination, there is little information available about the immune response induced at the vaccination site. Previously, an ... [more ▼]

Although Vaccinia virus (VACV) was used to eradicate smallpox by dermal vaccination, there is little information available about the immune response induced at the vaccination site. Previously, an intradermal murine model that mimics smallpox vaccination was established. Here, this model was used to investigate which leukocytes are recruited to the infected lesion and what are the kinetics of recruitment. Data presented show that VACV infection induced the infiltration of macrophages, followed by granulocytes and lymphocytes. Up to 4 days post-infection, the major lymphocyte population was TCRgammadelta T cells, but thereafter, there was a large recruitment of CD4(+) and CD8(+) T cells. Interestingly, the majority of T cells expressed the natural killer-cell marker DX5. This report is the first to characterize the local immune response sequence to VACV infection and represents a benchmark against which the responses induced by genetically modified VACVs may be compared. [less ▲]

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See detailAsthme et tabac.
Gusbin, N.; Garzaniti, N.; Louis, Renaud ULg

in Revue Médicale de Liège (2006), 61(2), 81-6

Roughly 40% of asthmatics are or have been smokers. These smoking asthmatics have been largely overlooked in the past. Tobacco is today considered as a risk factor for asthma and it seems that smoking ... [more ▼]

Roughly 40% of asthmatics are or have been smokers. These smoking asthmatics have been largely overlooked in the past. Tobacco is today considered as a risk factor for asthma and it seems that smoking asthmatics exhibit a different phenotype as compared to non smoking asthmatics. The inflammatory substrate differs widely, not only with respect to the type of cells present in the airways, but also with respect to the mediators brought into play. On the clinical point of view the asthma of smokers is also more severe that in non smokers, both at the symptomatic and the functional level. The asthma severity in smokers is partly linked to a resistance to inhaled corticoids, the cornerstone of maintenance treatment in asthma. This makes urgent to assess alternative treatment to inhaled corticoids for this asthma phenotype, but also emphasizes the need to support smoking cessation in asthmatics. [less ▲]

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See detailL'eotaxine, une chemokine importante dans l'asthme.
Hemelaers, L.; Louis, Renaud ULg

in Revue Médicale de Liège (2006), 61(4), 223-6

We know that the eosinophil plays an important role in asthma pathogenesis. This polynuclear cell is attracted into the airways by several chemokines. Eotaxin is one of them. Endothelial cells, smooth ... [more ▼]

We know that the eosinophil plays an important role in asthma pathogenesis. This polynuclear cell is attracted into the airways by several chemokines. Eotaxin is one of them. Endothelial cells, smooth muscle cells, epithelial cells, alveolar macrophages and eosinophils can produce eotaxin. In asthmatic airways, eotaxin production is increased in bronchial airway lumen and mucosa. Eotaxine actively participates in asthma pathogenesis by activating eosinophil recruitment. [less ▲]

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See detailLe cas clinique du mois. Le syndrome de Pierre-Marie Bamberger.[Clinical case of the month. Pierre Marie Bamberger syndrome]
Rouers, A.; Radermecker, Maurice ULg; Duysinx, Bernard ULg et al

in Revue Médicale de Liège (2006), 61(3), 142-4

We report the case of a lung adenocarcinoma revealed by clubbing and secondary hypertrophic osteoarthropathy or Pierre-Marie Bamberger syndrome.

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See detailPourquoi et comment structurer ses acquis en sciences à l'école primaire ?
Giot, Bernadette ULg; Quittre, Valérie ULg

in Site du Ministère de la Communauté française de Belgique (2006)

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See detailBiological Image Classification with Random Subwindows and Extra-Trees
Marée, Raphaël ULg; Geurts, Pierre ULg; Wehenkel, Louis ULg

Conference (2006)

We illustrate the potential of our image classification method on three datasets of images at different imaging modalities/scales, from subcellular locations up to human body regions. The method is based ... [more ▼]

We illustrate the potential of our image classification method on three datasets of images at different imaging modalities/scales, from subcellular locations up to human body regions. The method is based on random subwindows extraction and the combination of their classification using ensembles of extremely randomized decision trees. [less ▲]

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See detailFrom Expository Teaching to First e-Learning Course Production: Capture in a 17 Online Course Sample of a Pedagogical Pattern Facilitating Transition
Verpoorten, Dominique ULg; Poumay, Marianne ULg; Delcomminette, Séverine ULg et al

in Advanced Learning Technologies (2006)

This paper discusses an activity structure, RQAT, mined from a study of 17 on-line courses. It formats this structure as a pedagogical pattern and presents it as an abstraction to support staff ... [more ▼]

This paper discusses an activity structure, RQAT, mined from a study of 17 on-line courses. It formats this structure as a pedagogical pattern and presents it as an abstraction to support staff development, especially faculty willing to incorporate first online components to enhance face to face courses. [less ▲]

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See detailG-quadruplexes in telomeric repeats are conserved in a solvent-free environment
Baker, Erin Shammel; Bernstein, Summer L; Gabelica, Valérie ULg et al

in International Journal of Mass Spectrometry (2006), 253(3), 225-237

The structural properties of G-quadruplex forming sequences. such as the human telomeric repeat d(T(2)AG(3))(n), are of great interest due to their role in cancer and cellular aging. To determine if G ... [more ▼]

The structural properties of G-quadruplex forming sequences. such as the human telomeric repeat d(T(2)AG(3))(n), are of great interest due to their role in cancer and cellular aging. To determine if G-quadruplexes are present in a solvent-free environment. different lengths of the telomeric repeat d(T(2)AG(3))(n) (where n = 1, 2, 4 and 6) and dTG(4)T were investigated with mass specteometry, ion mobility and molecular dynamics calculations. Nano-ESI-MS illustrated quadruples stoichiometries compatible with G-quadruplex Structure.; for each sequence, with dT(2)AG(3) and dTG(4)T forming 4-strand complexes with two and three NH4+ adducts. d(T(2)AG(3))(2) a 2-strand complex. and d(T(2)AG(3))(4) and d(T(2)AG(3))(6) remaining single-stranded. Experimental cross sections were obtained for all species using ion mobility method.,. In all case.,. these could be quantitatively matched to model cross sections with specific strand orientations (parallel/antiparallel) and structures. For each species, the solvent-free structures agreed with the solution CD measurements, but the ion mobility/modeling procedure often gave Much more detailed structural information. (C) 2006 Elsevier B.V. All rights reserved. [less ▲]

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See detailInfluence of the non-linearity of the aerodynamic coefficients on the skewness of the buffeting drag force
Denoël, Vincent ULg; Degée, Hervé ULg

in Wind and Structures (2006), 9(6), 457-471

This paper is devoted to the non linear quasi-steady aerodynamic loading. A linear approximation is often used to compute the response of structures to buffeting forces. Some researchers have however ... [more ▼]

This paper is devoted to the non linear quasi-steady aerodynamic loading. A linear approximation is often used to compute the response of structures to buffeting forces. Some researchers have however shown that it is possible to account for the non linearity of this loading. This non linearity can come (i) from the squared velocity or (ii) from the shape of the aerodynamic coefficients (as functions of the wind angle of attack). In this paper, it is shown that this second origin can have significant implications on the design of the structure, particularly when the non linearity of the aerodynamic coefficient is important or when the transverse turbulence is important. [less ▲]

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