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See detailLes protheses tracheobronchiques: experience au CHU de Liege
Corhay, Jean-Louis ULg; Duysinx, Bernard ULg; Louis, Renaud ULg et al

in Revue Médicale de Liège (2004), 59(10), 577-83

During recent years the endobronchial prostheses has become an essential part of the therapeutic bronchoscopy in order to remove obstructions from the proximal airways, in malignant diseases, (principally ... [more ▼]

During recent years the endobronchial prostheses has become an essential part of the therapeutic bronchoscopy in order to remove obstructions from the proximal airways, in malignant diseases, (principally lung cancer) are in benign disorders. In this article we report our last ten year experience in stenting of the tracheo-bronchial tree. We will retrospectively review the indications of the stents, the type of prostheses and their modes of insertion, their complications, the clinical and functional results. [less ▲]

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See detailReporting systems in healthcare from a case-by-case experience to a general framework: an example in anaesthesia
Nyssen, Anne-Sophie ULg; Aunac, Sophie; Faymonville, Marie-Elisabeth ULg et al

in European Journal of Anaesthesiology (2004), 21(10), 757-765

Reporting systems are becoming more widespread in healthcare. Since they may become mandatory under the pressure of insurance companies and administrative organizations, it is important to begin to go ... [more ▼]

Reporting systems are becoming more widespread in healthcare. Since they may become mandatory under the pressure of insurance companies and administrative organizations, it is important to begin to go beyond a case-by-case approach and to move to a system where there is a general reflection on the best conditions of development and setting up of such systems in medicine. In this paper, we review existing reporting systems, break down their components, examine how they are constructed and propose some ideas on how to articulate them in a dynamic process in order to improve the validity of the tool as mediator of safety, quality and well-being at work. [less ▲]

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See detailA new training simulator for improved voltage control of the Hydro-Québec system
Van Cutsem, Thierry ULg; Hassé, Gaëtan; Moors, Cédric et al

(2004, October)

This paper reports on the development of a training simulator focusing on voltage control and stability. It has been derived from a quasi steady-state simulation software already used and validated in ... [more ▼]

This paper reports on the development of a training simulator focusing on voltage control and stability. It has been derived from a quasi steady-state simulation software already used and validated in planning and operational planning studies. The computational engine has been provided with a user interface built on the client-server architecture, allowing the simulator to run on a network of PCs in a very flexible way. New displays can be set up easily and quickly. This tool is presently used by Hydro-Québec to improve the operator’s ability to control transmission voltages. Other features, uses and benefits are reported. [less ▲]

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See detailCathepsin D processes human prolactin into multiple 16K-like N-terminal fragments: Study of their antiangiogenic properties and physiological relevance
Piwnica, David; Touraine, Philippe; Struman, Ingrid ULg et al

in Molecular Endocrinology (2004), 18(10), 2522-2542

16K prolactin (PRL) is the name given to the 16-kDa N-terminal fragment obtained by proteolysis of rat PRL by tissue extracts or cell lysates, in which cathepsin D was identified as the candidate protease ... [more ▼]

16K prolactin (PRL) is the name given to the 16-kDa N-terminal fragment obtained by proteolysis of rat PRL by tissue extracts or cell lysates, in which cathepsin D was identified as the candidate protease. Based on its antiangiogenic activity, 16K PRL is potentially a physiological inhibitor of tumor growth. Full-length human PRL ( hPRL) was reported to be resistant to cathepsin D, suggesting that antiangiogenic 16K PRL may be physiologically irrelevant in humans. In this study, we show that hPRL can be cleaved by cathepsin D or mammary cell extracts under the same conditions as described earlier for rat PRL, although with lower efficiency. In contrast to the rat hormone, hPRL proteolysis generates three 16K-like fragments, which were identified by N-terminal sequencing and mass spectrometry as corresponding to amino acids 1 - 132 ( 15 kDa), 1 - 147 (16.5 kDa), and 1 - 150 ( 17 kDa). Biochemical and mutagenetic studies showed that the species-specific digestion pattern is due to subtle differences in primary and tertiary structures of rat and human hormones. The antiangiogenic activity of N-terminal hPRL fragments was assessed by the inhibition of growth factor-induced thymidine uptake and MAPK activation in bovine umbilical endothelial cells. Finally, an N-terminal hPRL fragment comigrating with the proteolytic 17-kDa fragment was identified in human pituitary adenomas, suggesting that the physiological relevance of antiangiogenic N-terminal hPRL fragments needs to be reevaluated in humans. [less ▲]

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See detailReverberated sound field modeling in coupled rooms using a diffusion equation
Billon, Alexis ULg; Valeau, Vincent; Sakout, Anas et al

in Journal of the Acoustical Society of America (2004, October), 116(4), 2553-2553

Sound modeling in coupled rooms has attracted considerable attention in the past, but accurate and operational models are still needed. In recent papers, a diffusion equation based model has been applied ... [more ▼]

Sound modeling in coupled rooms has attracted considerable attention in the past, but accurate and operational models are still needed. In recent papers, a diffusion equation based model has been applied with success to unusual room shapes. This approach allows nonuniform repartition of energy, and is especially relevant in room acoustics for long rooms or complex spaces such as networks of rooms. The present work aims at validating the behavior of the diffusion model in the case of two acoustically coupled rooms separated by an open area. In this purpose, the time-dependent diffusion equation is solved in three dimensions using a finite-element solver. It allows one to predict both sound attenuation and reverberation time at any point of the coupled rooms. Parameters influencing the coupling, i.e., room relative sizes, aperture size and room absorption areas, are investigated. Results are then compared with the classical statistical theory of coupled rooms. Finally, a comparison with experimental data in two coupled classrooms is also provided. [less ▲]

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See detailElements pour une démocratie post-représentative
Jacquemain, Marc ULg

Scientific conference (2004, October)

Le texte interroge à quelles conditions une démocratie représentative peut-elle être dite réellement démocratique ? Il part des interrogations de Bernard Manin sur les limites de la représentation et ... [more ▼]

Le texte interroge à quelles conditions une démocratie représentative peut-elle être dite réellement démocratique ? Il part des interrogations de Bernard Manin sur les limites de la représentation et illustre les difficultés posées par l'exemple du dispositif participatif imaginé pour les travailleurs sans emploi en Wallonie. [less ▲]

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See detailCharacterization of a cavern conduit system in Vietnam by time series correlation, cross-spectrum and wavelet analyses
Tam, V. T.; De Smedt, F.; Batelaan, Okke et al

in Hydrological Sciences Journal = Journal des Sciences Hydrologiques (2004), 49(5), 879-900

Time series analyses are applied to characterize the transient flow regimes of the Nam La cavern conduit, northwest Vietnam. The conduit transforms the input signal to an output signal, and the degree of ... [more ▼]

Time series analyses are applied to characterize the transient flow regimes of the Nam La cavern conduit, northwest Vietnam. The conduit transforms the input signal to an output signal, and the degree of transformation provides information on the nature of the flow system. The input for the analysis is net precipitation and the flow hydrograph at the cave entrance, while the output series is the flow hydrograph at the resurgence. Cross-correlation and cross-spectrum analysis are used to investigate the stationarity and linearity of the input-output transformation of the system, resulting in hydrodynamic properties such as system memory, response time, and mean delay between input and output. It is shown that during high flow periods, the flow in the conduit is pressurized. Consequently, the linear input-output assumption holds only for low flows. To highlight the hydrodynamics of the cavern conduit for the high flow periods, wavelet spectrum and wavelet cross-spectrum analyses are applied. [less ▲]

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See detailModelling seasonal variations in nitrate and sulphate concentrations in a vulnerable alluvial aquifer
Peeters, Luk; Haerens, Bruno; Van der Sluys, Jan et al

in Environmental Geology (2004), 46(6-7), 951-961

The Eisden-Meeswijk region in Belgium has been affected by mining subsidence due to the deep coal mining activities. Groundwater levels in the alluvial plain of the Meuse River are maintained below the ... [more ▼]

The Eisden-Meeswijk region in Belgium has been affected by mining subsidence due to the deep coal mining activities. Groundwater levels in the alluvial plain of the Meuse River are maintained below the ground surface by drainage installations and municipal well fields. A correlation between the water level in the Meuse River and the variation in nitrate and sulphate concentrations in the aquifer has been observed. A transient groundwater model is developed for the period May 1998-May 2002 and advective transport simulations have been carried out using this model. During dry periods, the major groundwater flow is directed towards the Meuse River, thereby feeding the river. During wet periods, however, groundwater flows in the opposite direction. Due to these variations in groundwater flow direction and to the extraction of groundwater, zones of higher solute concentration exist of which the position and extension vary both spatially and temporally. [less ▲]

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See detailProjet PEPS Portail électronique de périodiques scientifiques : Étude de faisabilité pour la réalisation d’une plate-forme de mise en ligne de revues scientifiques en Communauté française Wallonie-Bruxelles
Baguet, Muriel; Bernard, Robert; Brouwer, Christian et al

Report (2004)

Étude commanditée à la Bibliothèque Interuniversitaire de la Communauté française de Belgique (BICfB) par la Ministre de Enseignement supérieur et de la Recherche scientifique de la Communauté française ... [more ▼]

Étude commanditée à la Bibliothèque Interuniversitaire de la Communauté française de Belgique (BICfB) par la Ministre de Enseignement supérieur et de la Recherche scientifique de la Communauté française Wallonie-Bruxelles afin d'étudier la faisabilité de la création d'une plateforme de publication Open Access des périodiques scientifiques publiés en Communauté Wallonie-Bruxelles. [less ▲]

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See detailDevelopment of Advanced Driver Assistance Systems by means of the traffic flow simulation tool PELOPS with HiL-functionalities
Christen, Fréderic ULg; Benmimoun, A.; Breuer, K. et al

in Berechnung und Simulation im Fahrzeugbau (2004, September 29)

During the last years a rapid increase of traffic volume in association with limited road space could be observed. This led to a raising load of the driver while achieving his driving tasks. Therefore so ... [more ▼]

During the last years a rapid increase of traffic volume in association with limited road space could be observed. This led to a raising load of the driver while achieving his driving tasks. Therefore so called Advanced Driver Assistance Systems (ADAS) are under development in recent years with an upward tendency. Such systems will relieve the driver and improve safety on the road in the future. A rising number of computed-aided-simulation becomes important for the development and evaluation of such systems. Developing ADAS makes a specific demand on the simulation environment. ADAS interact strongly with their traffic environment. Therefore the simulation has to cover both, a detailed model of the ego vehicle and an adequate representation of the traffic environment. The traffic flow simulation program PELOPS meets these requirements. The newly implemented extension of PELOPS with techniques of Software- and Hardware-in-the-Loop-simulation (SiL- and HiL-simulation) allows system developers a fast functional check and an assessment of new ADAS. External software can be linked to PELOPS via Ethernet-based network communication, which has already been realised for the widely used development tool MATLAB/Simulink. Besides the Ethernet interface PELOPS-HiL (PHIL) gives the developer two other possibilities for providing a HIL-environment: a serial interface which can be used for a connection to a dSpace development platform and a CAN data bus interface. The following article describes by means of chosen examples how flexible the PHIL-simulation can be adapted to a development task and which results can be obtained. [less ▲]

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See detailEvidence-Based Veterinary Medicine
Pasleau, Françoise ULg; Vandenput, Sandrina ULg; Fairon, Nicolas ULg et al

Conference (2004, September 24)

At the University of Liege, the medical library recently merged with several entities including the libraries of Zoology, Botany, Psychology and Veterinary Medicine. Everywhere, the librarians are ... [more ▼]

At the University of Liege, the medical library recently merged with several entities including the libraries of Zoology, Botany, Psychology and Veterinary Medicine. Everywhere, the librarians are involved in teaching activities and users training programs are rather well developped in every field. But the comparison of the curriculum contents points to a few amazing differences. The most surprising one is the approach of Evidence-Based Medicine (EBM). The concept is well introduced in the medical community and it is a legal obligation for the medical students to be thaught in and to practice EBM. Surprisingly, the veterinarians don't seem very interested. Besides its impact on clinical practice, EBM is a good opportunity to create new habits that are valuable for continuing education and to develop critical appraisal skills. Thus, we wish to analyze the reasons that might explain why EBM seems to be left aside at the Faculty of Veterinary Medicine. Two approaches are envisionned. First, we plan to ask the Faculty itself about its position regarding the concept. Surveys and interviews will be conducted, distinguishing between the general practitionners, the researchers and the teaching staff. On the other hand, an in depth analysis will be conducted regarding the media available at the veterinary library. Are they suited to the practice of EBM? If not, which additional tools should be purchased ? At the end of the process, we expect to be able to adapt the content of the training sessions we offer to library users and possibly to improve the collaboration with the veterinary teaching staff. [less ▲]

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See detailMédias et vérité
Durand, Pascal ULg

Article for general public (2004)

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See detailUniversité - humanité
Legros, Willy ULg

Speech (2004)

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See detailUtilization of a probiotic-hemicellulases combination to prevent effects of Salmonella contamination of broilers
Dubois Dauphin, Robin ULg; Vandeplas, Sabrina ULg; Welling, Gjalt W. et al

in Proceedings of the Ninth Conference on Food Microbiology (2004, September 16)

The aim of this study was to determine the effectiveness of a combination probiotic - hemicellulases by its relative incidence on gastrointestinal (GI) tract microbiota, correlated to the animal ... [more ▼]

The aim of this study was to determine the effectiveness of a combination probiotic - hemicellulases by its relative incidence on gastrointestinal (GI) tract microbiota, correlated to the animal performances during the growing period of broilers infected or not with Salmonella typhimurium [less ▲]

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See detailRapid improvement of bone metabolism after infliximab treatment in Crohn's disease
Franchimont, N.; Putzeys, V.; Collette, Julien ULg et al

in Alimentary Pharmacology & Therapeutics (2004), 20(6), 607-614

BACKGROUND: Crohn's disease is associated with low bone mineral density and altered bone metabolism. AIM: To assess the evolution of bone metabolism in Crohn's disease patients treated with infliximab ... [more ▼]

BACKGROUND: Crohn's disease is associated with low bone mineral density and altered bone metabolism. AIM: To assess the evolution of bone metabolism in Crohn's disease patients treated with infliximab. METHODS: We studied 71 Crohn's disease patients treated for the first time with infliximab for refractory Crohn's disease. Biochemical markers of bone formation (type-I procollagen N-terminal propeptide, bone-specific alkaline phosphatase, osteocalcin) and of bone resorption (C-telopeptide of type-I collagen) were measured in the serum before and 8 weeks after infliximab therapy and compared with values in a matched healthy control group. RESULTS: Eight weeks after treatment with infliximab, a normalization of bone markers was observed with a median increase in formation markers of 14-51% according to marker and a lower but significant decrease in resorption marker (median 11%). A clinically relevant increase in bone formation markers was present in 30-61% of patients according to the marker. A clinically relevant decrease in C-telopeptide of type-I collagen was present in 38% of patients. No association was found with any tested demographic or clinical parameter. CONCLUSION: Infliximab therapy in Crohn's disease may rapidly influence bone metabolism by acting either on bone formation or bone resorption. This improvement seems to be independent of clinical response to infliximab. [less ▲]

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See detailVALUE: analysis of results
Scheen, André ULg

in Lancet (2004), 364(9438), 932-933935

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See detailBulletin agrométéorologique - Août 2004
Tychon, Bernard ULg; Ozer, Pierre ULg; Horion, S. et al

in Bulletin Agrométéorologique (2004), 3(5), 1-4

Le mois d’août a été caractérisé par des précipitations, des vitesses de vent et une humidité anormalement élevées. Les valeurs de rayonnement étaient par contre anormalement faibles. Les rendements ... [more ▼]

Le mois d’août a été caractérisé par des précipitations, des vitesses de vent et une humidité anormalement élevées. Les valeurs de rayonnement étaient par contre anormalement faibles. Les rendements prévus pour le maïs fourrager sont légèrement inférieurs à ceux observés au cours des cinq années antérieures. Par contre, concernant la betterave sucrière et la pomme de terre mi-hâtive, la tendance est inverse avec des estimations globalement supérieures à la moyenne des cinq dernières années. [less ▲]

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See detailHost-derived plasminogen activator inhibitor-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth
Bajou, Khalid ULg; Maillard, Catherine ULg; Jost, M. et al

in Oncogene (2004), 23(41), 6986-6990

Plasminogen activator inhibitor type 1 (PAI-1) plays a key role in tumor progression and is believed to control proteolytic activity and cell migration during angiogenesis. We report here that host PAI-1 ... [more ▼]

Plasminogen activator inhibitor type 1 (PAI-1) plays a key role in tumor progression and is believed to control proteolytic activity and cell migration during angiogenesis. We report here that host PAI-1, at physiological concentration, promotes in vivo tumor invasion and angiogenesis. In sharp contrast, inhibition of tumor vascularization was observed when PAI-1 was produced at supraphysiologic levels, either by host cells (transgenic mice overexpressing PAI-1) or by tumor cells (after transfection with murine PAI-1 cDNA). This study provides for the first time in vivo evidence for a dose-dependent effect of PAI-1 on tumor angiogenesis. Of great interest is the finding that PAI-1 produced by tumor cells, even at high concentration, did not overcome the absence of PAI-1 in the host, emphasizing the importance of the cellular source of PAI-1. [less ▲]

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See detailEtude expérimentale du peptide oblique de l’α-synucléine
Crowet, Jean-Marc ULg

Master of advanced studies dissertation (2004)

The study of amyloidogenic proteins is of great interest in biochemistry because these proteins undergo a conformational change and an aggregation, that are largely implicated in several incurable ... [more ▼]

The study of amyloidogenic proteins is of great interest in biochemistry because these proteins undergo a conformational change and an aggregation, that are largely implicated in several incurable diseases including Alzheimer’s, Parkinson’s or Creutzfeldt-Jakob’s disease. In addition, these phenomena are not completely understood, either structurally or energetically. These proteins, in their amyloidogenic conformation, aggregate rapidly in solution and form fibrils that are insoluble and resistant to proteolysis. Recently, tilted peptides were detected in two of the amyloidogenic proteins involved in neurodegenerative diseases; the amyloid β peptide responsible for Alzheimer’s disease, and the PrP protein that causes Creutzfeldt-Jakob’s disease. Tilted peptides are short protein fragments (11 to 18 residues) that adopt a tilted orientation when inserted into biological membranes, which they are able to destabilise. When helical, tilted peptides present an asymmetric hydrophobicity gradient responsible for their oblique insertion. Tilted peptides have also been detected in some other amyloidogenic proteins. In a set of 27 amyloidogenic proteins, five tilted peptides from four different proteins have been shown up by molecular modelling. Tilted peptides could be responsible for the neurotoxic effect of these proteins. Thanks to their fusogenic properties, they could interact directly with the membrane leading to cell death. Tilted peptides could also be involved in the tranconformational process of these proteins. The aim of this study was to characterise experimentally the tilted peptide detected by molecular modelling in the α-synuclein sequence, responsible for Parkinson’s disease. This peptide is tested experimentally to highlight its lipid destabilising properties. Its conformation is studied by IR spectroscopy. The fusogenic assays point to its destabilizing properties. [less ▲]

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