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See detailChromosome 12q24.3 controls sensitization to cat allergen in patients with asthma from Siberia, Russia
Gusareva, Elena ULg; Bragina, Elena; Buinova, Svetlana et al

in Immunol Letters (2009), 125(1), 1-6

In Russian population of Siberia asthma is usually concomitant with high sensitization to indoor allergens (cat, dog and house dust mites), overproduction of total immunoglobulin E (IgE) and airway ... [more ▼]

In Russian population of Siberia asthma is usually concomitant with high sensitization to indoor allergens (cat, dog and house dust mites), overproduction of total immunoglobulin E (IgE) and airway hyperreactivity. Definition of genes that predispose to development of various sub-components of the asthma phenotype is important for understanding of etiology of this disease. To map genes predisposing to asthma,we tested 21 microsatellite markers from candidate chromosomal regions in 136 Russian nuclear families with asthma from Siberia.We performed non-parametric analysis for linkage with asthma, total IgE, specific IgE to cat, dog, and dust mites, and spirometric indices (FEV1 (%) – percentage of predicted forced expiratory volume in 1 s, FVC (%) – percentage of predicted forced vital capacity, and FEV1/FVC (%) – Tiffenau index). The most significant linkagewas to the candidate region on chromosome 12. Locus controlling cat-specific IgE, which is the most abundant in asthma patients fromSiberian population, mapped within the interval between 136 and 140 cM on chromosome 12q24.3, with the suggestive linkage at the marker D12S1611 (LOD= 2.23, P = 0.0007). Total IgE was also linked to this region (D12S1611 – LOD= 1.12, P = 0.012). FEV1 (%) exceeded LOD> 1 threshold for significance with the same locus 12q24.3, but with the peak at a more proximal region at 111.87cM (D12S338 – LOD= 1.21, P = 0.009). Some evidence of linkage (LOD> 1.0) was also detected for asthma at 6p21.31 (D6S291) and total IgE at 13q14.2 (D13S165). These data indicate that the locus 12q24.3 is the most promising candidate for identification of asthma genes in Russian population of Siberia. [less ▲]

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See detailLongitudinal analysis of ordinal data
Donneau, Anne-Françoise ULg; Mauer, M

Conference (2009, June 30)

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See detailUn outil d’aide à la décision pour la gestion des chablis en Région wallonne (Belgique)
Riguelle, Simon ULg; Hebert, Jacques ULg; Jourez, Benoît ULg

Poster (2009, June 30)

The poster highlights the main steps leading to the development of a decision-support tool for storm damage management by the forest sector at a regional scale.

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See detailScabies in a llama (Lama glama): control with moxidectin long acting (Cydectin®LA)
Caron, Yannick ULg; Cavadino, Céline; Losson, Bertrand ULg

Poster (2009, June 29)

An adult neutered male llama (Lama glama) was presented for examination with a history of a severe long lasting (3 years) and recurrent itch and crust formation. Three years ago, scabies had been ... [more ▼]

An adult neutered male llama (Lama glama) was presented for examination with a history of a severe long lasting (3 years) and recurrent itch and crust formation. Three years ago, scabies had been diagnosed by a local vet on the basis of clinical signs; the animal was treated several times with ivermectin (Ivomec®) injectable and phoxim (Sarnacuran®). After each treatment there was a marked clinical improvement but relapse was the rule within 1 to 2 months. During the two years preceeding our first visit the animal had received local applications of Sarnacuran every two to three weeks wich resulted in incomplete control. None of the owners had reported skin lesions compatible with scabies. On February 27th 2009 the animal showed a marked pruritus accompanied by very thick scabs and alopecia on the face (around the mouth and ears), shoulders, forelegs, hindlegs, abdomen, flanks and the tail. Clinical examination revealed a fairly good general condition. Abnormalities were limited to the skin. Skin scrapings were taken and numerous Sarcoptes scabiei mites were subsequently detected microscopically. Sedation and analgesia were performed via the intramuscular administration of xylazine (Vexylan®) at 0.5 mg/kg. The scabs were humidified with a camomile infusion and a maximum of material was removed and destroyed. Then the llama was treated with 10% moxidectin (Cydectin LA®) at 1 mg/kg by subcutaneous injection at the basis of the ear. On April 6th 2009, a very marked clinical improvement was observed: most of the scabs had dissapeared and hair regrowth in previously alopecic area was observed. Skin scrapings were negative. However, some pruritus was still observed and a second treatment with Cydectin LA was given. According to the owner who was contacted by phone in early May the clinical condition of the animal has further improved. A final visit is planned to assess the clinical and parasitological cure in this S. scabiei infected llama. At our knowledge, this is the first time Cydecin LA is used in llama for the treatment of scabies. [less ▲]

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See detailEtude de la modulation de la NO synthase 2 par l'éxtrait de pépins de raisin, au cours de l'hydatidose humaine: Impact sur la production du monoxyde d'azote (NO)
Blibek, Karim ULg

Master of advanced studies dissertation (2009)

Résumé L’hydatidose est une zoonose cosmopolite qui sévit de façon endémique en Algérie. Cette parasitose est causée par la forme larvaire d’un cestode Echinococcus granulosus. Le diagnostic de ... [more ▼]

Résumé L’hydatidose est une zoonose cosmopolite qui sévit de façon endémique en Algérie. Cette parasitose est causée par la forme larvaire d’un cestode Echinococcus granulosus. Le diagnostic de l’hydatidose orienté par les arguments cliniques et radiologiques reste largement dominé par l’immunosérologie. L’établissement d’un diagnostic de certitude est délicat, notamment en raison de la vaste communauté antigénique que constitue l’hydatide. Dans la mesure où cette affection est souvent asymptomatique, le traitement reste essentiellement chirurgical avec risque de récidive. La survenue de complications au cours de l’évolution de cette macroparasitose et l’apparition d’échinococcose secondaire rendent l’acte chirurgical difficile. Dans l’optique de la recherche d’une thérapie anti-hydatique et sur la base de plusieurs travaux ayant déjà permis de mettre en évidence le rôle de certaines molécules dans la réponse immunitaire contre le parasite, nous nous sommes intéressé à l’étude de l’effet de l’extrait des pépins de raisin sur la culture des PBMC sensibilisées au liquide hydatique. Parmi les facteurs solubles impliqués dans les mécanismes anti parasitaires, on cite le monoxyde d’azote, qui est définit comme étant un biomédiateur synthétisé par les NO synthases (NOS). C’est un messager intracellulaire et un agent effecteur de nombreuses fonctions biologiques, il a été détecté au cours de microparasitoses telles que la leishmaniose. Ce radical hautement réactif intervenant dans l’inflammation serait impliqué dans les mécanismes de défense de l’hôte contre E.granulosus au cours de l’hydatidose. Le but de ce travail est d’apporter des arguments en faveur du rôle anti-inflammatoire de l’extrait des pépins de raisin sur la modulation de la sécrétion du NO au cours de l’hydatidose. Notre travail s’est essentiellement porté sur : Le dosage des protéines du liquide hydatique issu de patients porteurs de kystes hydatiques selon plusieurs localisations, le test de viabilité des protoscolex récupérés à partir du liquide hydatique, l’implication in vitro des PBMC dans la biosynthèse du NO, stimulés par le liquide hydatique et l’étude in vitro de l’effet anti inflammatoire de l’extrait des pépins de raisin, dans la variation des taux de production du NO à partir des PBMC stimulés au liquide hydatique. Les tests in vitro ont montré que l’extrait des pépins de raisin aurait un effet modulateur négatif sur la production du NO. Une corrélation positive a été rapportée entre l’expression de la NOS II et le taux de NO produit. Cette expression serait négativement corrélée par l’effet inhibiteur de l’extrait des pépins de raisin à une dose inférieur à 20 µg/ml. Cette molécule anti-inflammatoire pourrait avoir un effet souhaitable lors d’une bithérapie anti-hydatique, dans le sens où elle modulerait la sécrétion du NO et éviterait ainsi son effet cytotoxique. [less ▲]

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See detailL’apport des focus groups dans la compréhension des structures de raisonnement quant à la conscientisation accompagnant la transmission des faits génocidaires
Grandjean, Geoffrey ULg

Conference (2009, June 26)

La transmission des faits génocidaires auprès des jeunes générations semble être accompagnée d’une conscientisation favorisant l’adoption par les adolescents de certains comportements ou attitudes. Pour ... [more ▼]

La transmission des faits génocidaires auprès des jeunes générations semble être accompagnée d’une conscientisation favorisant l’adoption par les adolescents de certains comportements ou attitudes. Pour appréhender cette conscientisation, des focus groups ont été réalisés auprès d’adolescents belges francophones (âgés de 16 à 18 ans). Le but était de voir, à travers les discussions, comment ces jeunes ont internalisé la conscientisation accompagnant la transmission des faits génocidaires. Cette communication contribue ainsi au débat méthodologique qui entoure l’utilisation des focus groups dans la recherche en science politique et sociale et plus particulièrement pour saisir les structures de raisonnement de ces jeunes, considérées dans une dynamique sociale. Afin d’illustrer ce propos, quelques résultats sont présentés. [less ▲]

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See detailLa prévention médicalisée est-elle néfaste pour nos patients ? Et à quelles conditions leur serait-elle bénéfique ?
Vanmeerbeek, Marc ULg

Conference (2009, June 25)

En examinant nos pratiques en prévention, il semble nécessaire de mieux asseoir la validité scientifique de nos actes, e.a. en prenant de la distance par rapport aux pressions commerciales. Il serait ... [more ▼]

En examinant nos pratiques en prévention, il semble nécessaire de mieux asseoir la validité scientifique de nos actes, e.a. en prenant de la distance par rapport aux pressions commerciales. Il serait utile de rapprocher la médecine générale et la santé publique, en augmentant la place de la promotion de la santé et ne développant la place du patient. De nouvelles tâches sont à imaginer dans un partenariat multidisciplinaire. [less ▲]

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See detailÉtude des apports en éléments traces métalliques dans la tourbière du Misten (Hautes-Fagnes): Niveau de contamination et variabilité spatiale.
Allan, Mohammed ULg

Master's dissertation (2009)

Le but de notre travail était d'étudier l'histoire de la pollution des métaux traces dans la région de Misten (Belgique) au niveau local et au niveau régional, et de placer la pollution industrielle dans ... [more ▼]

Le but de notre travail était d'étudier l'histoire de la pollution des métaux traces dans la région de Misten (Belgique) au niveau local et au niveau régional, et de placer la pollution industrielle dans cette région dans une perspective historique plus large. [less ▲]

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See detailPUBLICITE AUTOMOBILE: Impact des propositions de loi DOC 1909/001 & DOC 1910/001
Ozer, Pierre ULg

Report (2009)

Ce rapport d'expertise réalisé à la demande de la Commission de la Santé publique, de l'Environnement et du Renouveau de la Société de la Chambre des Représentants de Belgique et présenté le 26 juin 2009 ... [more ▼]

Ce rapport d'expertise réalisé à la demande de la Commission de la Santé publique, de l'Environnement et du Renouveau de la Société de la Chambre des Représentants de Belgique et présenté le 26 juin 2009 analyse la publicité automobile via [1] son impact indirect sur les émissions de CO2 du secteur transport; [2] son illégalité flagrante au regard de la Directive européenne 1999/94/CE concernant « la disponibilité d’informations sur la consommation de carburant et les émissions de CO2 à l’intention des consommateurs lors de la commercialisation des voitures particulières neuves » transposée en droit belge par l’arrêté royal du 5 septembre 2001 du même nom; et [3] l’impact des propositions de loi DOC 1909/001 et DOC 1910/001. [less ▲]

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See detail‘Dagongzhe’ Write to the magazines: suffering, borders stretching and longings. Dialectics of identification and legitimation
Florence, Eric ULg

Conference (2009, June 23)

‘Dagongzhe’ Write to the magazines: suffering, borders stretching and longings. Dialectics of identification and legitimation. Eric Florence, PhD in Political and Social Sciences, Researcher at the Centre ... [more ▼]

‘Dagongzhe’ Write to the magazines: suffering, borders stretching and longings. Dialectics of identification and legitimation. Eric Florence, PhD in Political and Social Sciences, Researcher at the Centre for Ethnic and Migration Studies, the University of Liege. In this paper, I will look at the different kinds of values that are fostered within articles (diaries, letters, etc.) published in magazines for rural migrant workers. After having detailed the criterion used by editors of these magazines in the process of selecting or rejecting writings sent to them by migrant authors, I will detail three types of narrative modes found in magazines aimed at migrant workers. The first one signals suffering, disillusionment and sometimes irony. The second narrative mode entails claim making by migrant workers which are often backed by editors. I argue that this belongs to what O’Brien calls “contentious politics”. Eventually, the third mode examined in this paper will be thought of as strategic narrative framing on the part of migrant authors. In such framing the pedagogic role of guidance by editors is central I shall stress. But I shall argue at the same time that despite such framing, much of these writings are permeated by a powerful politics of desire and that such politics is particularly hard to analyse. In addition to a qualitative analysis of both published and unpublished writings by migrant workers and editors, I will also confront such writings and the values they convey to the fruit of my ethnographic fieldwork carried out in the Pearl River Delta between 2001 and 200 [less ▲]

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See detailSome Remarks on Dominique Pradelle's Lecture: "Does Husserl have a Reducibility Principle?"
Dewalque, Arnaud ULg

Conference (2009, June 23)

Comments on D. Pradelle's lecture (for details, see the attached document).

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See detailApplying control volume finite element for modelling direct injection boom spraying flow
El Aissaoui, Abdellah; Lebeau, Frédéric ULg; Destain, Marie-France ULg et al

Conference (2009, June 23)

Assessment of injection lag transport and uniformity of direct injection boom sprayer is an important issue for successful variable rate spraying technology. To estimate the boom lag transport and ... [more ▼]

Assessment of injection lag transport and uniformity of direct injection boom sprayer is an important issue for successful variable rate spraying technology. To estimate the boom lag transport and pressure loss, a numerical model is formulated on the basis of fluid hydrodynamic conservation equations. The software is implemented in visual basic. To solve the pressure – velocities equations, control volume finite element method (CV) is used to delimit elementary volumes of the boom. Linearization of the conservation laws is ensured by considering discrete form of the equations and calculating velocity and pressure step by step throughout the whole boom. The flow behaviour is simulated into a boom section divided into N elementary volumes, each of them including one nozzle. To test the model, three boom diameters (5, 6 and 8 mm) and two chemical viscosities (10-6 and 10-5 m2/s) were used. Experimental trials are carried out on boom having 2.5 m length (5 nozzles) for measuring pressure gradient and lag transport. Results showed that the model can predict the pressure losses and the lag transport accurately (error within 5%) to optimize boom designs. [less ▲]

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See detailAnalyse comparative de différentes modalités d’électrostimulation du quadriceps fémoral
Tubez, François ULg

Master's dissertation (2009)

Objectif : Cette étude a pour but d’apprécier la pertinence d’une innovation technologique (fonction Mi-Scan, société Compex) proposée dans la gamme des stimulateurs à vocation rééducative et/ou sportive ... [more ▼]

Objectif : Cette étude a pour but d’apprécier la pertinence d’une innovation technologique (fonction Mi-Scan, société Compex) proposée dans la gamme des stimulateurs à vocation rééducative et/ou sportive. Cette analyse porte sur l’efficacité excitomotrice et sur les qualités métrologiques de cette fonction. Méthode : Une comparaison des moments de forces évoqués électriquement au niveau du quadriceps avec et sans l’aide de cette fonction a été réalisée, et ce à intensité sous-maximale et maximale de stimulation. Par ailleurs, cette fonction a été explorée dans des conditions identiques à diverses reprises (étude de reproductibilité). Résultats : Il n’existait pas d’efficacité supérieure d’un montage utilisant la fonction "Mi" par rapport à un montage ne possédant pas cette fonctionnalité. De manière additionnelle, nos résultats ont permis de mettre en évidence que la reproductibilité des mesures effectuées par le senseur "Mi" était médiocre. Discussion : De grandes réserves doivent donc être émises concernant la validité et la fiabilité de cet outil. [less ▲]

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See detailLe comportement des tôles courbes comprimées et raidies longitudinalement
Peigneux, Christophe ULg

Master's dissertation (2009)

The current architectural trends show a growing desire to design bridges including curved compressed and longitudinally stiffened plates. Designers are increasingly faced with the problem of designing ... [more ▼]

The current architectural trends show a growing desire to design bridges including curved compressed and longitudinally stiffened plates. Designers are increasingly faced with the problem of designing such plates. There is currently no analytical approach to solve this problem. The solution consists in performing numerical simulations. However, this solution is very costly in both time and resources. The purpose of this work is to propose a simple analytic method for the design of curved longitudinally stiffened compressed plates. This approach consists in adapting the rules of the Eurocode EN 1993, part 1.5 (valid only for plane plates) on the basis of the foundations of the approach applicable to curved plates compressed but not stiffened. The aim is to allow the characterization of the loss in efficiency due to the curvature of the plate in the presence of longitudinal stiffeners. First, we performed a series of numerical simulations using the nonlinear finite element analysis program FINELG. The purpose of these simulations is twofold : on the one hand to analyze and to understand the behaviour of curved longitudinally stiffened plates ; secondly to obtain a representative set of ultimate loads that we can use in the future to validate the proposed methods. Three analytical design approaches were considered, each based on the general principle of replacing the basic plate by an equivalent isotropic plate whose parameters are adjusted accordingly. The three techniques differ in the principle of equivalence used. Two of these solutions have achieved promising results. [less ▲]

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See detailetude de la diversité enzymatique des microorganismes du sol par l'approche métagénomique
Berlemont, Renaud ULg

Doctoral thesis (2009)

Functional metagenomic approach was performed using total environmental DNA extracted from a temperate forest soil sample and from an Antarctica soil sample. Searching for clones harbouring phenotypes ... [more ▼]

Functional metagenomic approach was performed using total environmental DNA extracted from a temperate forest soil sample and from an Antarctica soil sample. Searching for clones harbouring phenotypes related to the production of new hydrolytic enzyme allows the isolation of several new enzymes. Amongst them, an esterase and a cellulase, named RBest1 and RBcel1 respectively, were characterized. By accurate description of their catalytic proprieties these two new enzymes appear to present interesting features. The RBest1 esterase is an enzyme whose activity is stabilised or improved in presence of non water-miscible organic solvent. By sequence analysis, RBest1 is related to other organic solvent tolerant enzyme. Moreover, in aqueous buffer, RBest1 is highly specific for butyrate compound but surprisingly its specificity appears to be shifted in presence of organic solvent. The RBcel1 cellulase, was thoroughly characterized for its involvement both in cellulose degradation and production. Our data highlight the requirement for such enzyme in the bacterial cellulose synthesis process. According to our results, the mining of metagenomic libraries by functional screening associated to detailed description of the isolated enzymes gives hints for both ecological and microbiological questions. [less ▲]

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See detailProposed design rules for iron columns reinforced by FRP
Ly, Dong Phuong Lam ULg; Demonceau, Jean-François ULg; Jaspart, Jean-Pierre ULg et al

in Mazzolani, F. M. (Ed.) Protection of historical buildings, Prohitech 09 (2009, June 21)

This paper presents design rules for iron columns under axial compression, strengthened with high modulus carbon fibre reinforced polymer (FRP) sheets. According to experimental and numerical results, it ... [more ▼]

This paper presents design rules for iron columns under axial compression, strengthened with high modulus carbon fibre reinforced polymer (FRP) sheets. According to experimental and numerical results, it is shown that the resistance and stiffness of iron columns can be significantly increased with the use of longitudinal FRP sheets because of the reduction of the column slenderness, but also that transverse FRP sheets should be used to prevent any local buckling of the longitudinal FRP sheets [less ▲]

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See detailFret ferroviaire : vue prospective
Arda, Yasemin ULg; Nondonfaz, Robert ULg

Article for general public (2009)

Livre blanc de la Commission Européenne. Faiblesses du transport ferroviaire de fret : interopérabilité, ferroutage

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See detailProduction of polymer/clay nanocomposite foams with improved fire behaviour using supercritical fluid technology
Urbanczyk, Laetitia ULg; Calberg, Cédric ULg; Detrembleur, Christophe ULg et al

Poster (2009, June 19)

In this study, supercritical CO2 is successfully used as foaming agent to prepare poly(styrene-co-acrylonitrile) (SAN) foams containing a low amount of well-dispersed nanoclay (5wt%). This kind of ... [more ▼]

In this study, supercritical CO2 is successfully used as foaming agent to prepare poly(styrene-co-acrylonitrile) (SAN) foams containing a low amount of well-dispersed nanoclay (5wt%). This kind of nanofiller has an influence both on material cellular morphology and fire property. In fact, SAN foam filled with nanoclay has smaller cells and higher density compared to unfilled foam. Moreover, the nanocomposite foam burns more slowly and without producing any burning droplets, which is highly desirable when considering housing applications. [less ▲]

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See detailSolar-Like Oscillations in a Massive Star
Belkacem, K.; Samadi, R.; Goupil, M.-J. et al

in Science (2009), 324

Seismology of stars provides insight into the physical mechanisms taking place in their interior, with modes of oscillation probing different layers. Low-amplitude acoustic oscillations excited by ... [more ▼]

Seismology of stars provides insight into the physical mechanisms taking place in their interior, with modes of oscillation probing different layers. Low-amplitude acoustic oscillations excited by turbulent convection were detected four decades ago in the Sun and more recently in low-mass main-sequence stars. Using data gathered by the Convection Rotation and Planetary Transits mission, we report here on the detection of solar-like oscillations in a massive star, V1449 Aql, which is a known large-amplitude (beta Cephei) pulsator. [less ▲]

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