Publications ORBi OA
Bookmark and Share    
Full Text
Peer Reviewed
See detailMechanical properties of highly porous PDLLA/Bioglass (R) composite foams as scaffolds for bone tissue engineering
Blaker, Jonny J.; Maquet, Véronique; Jérôme, Robert ULg et al

in Acta Biomaterialia (2005), 1(6), 643-652

This study developed highly porous degradable composites as potential scaffolds for bone tissue engineering. These scaffolds consisted of poly-d,l-lactic acid filled with 2 and 15 vol.% of 45S5 Bioglass® ... [more ▼]

This study developed highly porous degradable composites as potential scaffolds for bone tissue engineering. These scaffolds consisted of poly-d,l-lactic acid filled with 2 and 15 vol.% of 45S5 Bioglass® particles and were produced via thermally induced solid–liquid phase separation and subsequent solvent sublimation. The scaffolds had a bimodal and anisotropic pore structure, with tubular macro-pores of 100 μm in diameter, and with interconnected micro-pores of 10–50 μm in diameter. Quasi-static and thermal dynamic mechanical analysis carried out in compression along with thermogravimetric analysis was used to investigate the effect of Bioglass® on the properties of the foams. Quasi-static compression testing demonstrated mechanical anisotropy concomitant with the direction of the macro-pores. An analytical modelling approach was applied, which demonstrated that the presence of Bioglass® did not significantly alter the porous architecture of these foams and reflected the mechanical anisotropy which was congruent with the scanning electron microscopy investigation. This study found that the Ishai–Cohen and Gibson–Ashby models can be combined to predict the compressive modulus of the composite foams. The modulus and density of these complex foams are related by a power-law function with an exponent between 2 and 3. [less ▲]

Detailed reference viewed: 135 (9 ULg)
Full Text
Peer Reviewed
See detailOxytocin receptor pattern of expression in primary lung cancer and in normal human lung
Pequeux, Christel ULg; Breton, C.; Hagelstein, M. T. et al

in Lung Cancer (2005), 50(2), 177-188

In order to assess if oxytocin- and vasopressin-induced mitogenic effects detected on small-cell lung carcinoma (SCLC) cell lines could be transposed on primary SCLC, the aim of the present work was to ... [more ▼]

In order to assess if oxytocin- and vasopressin-induced mitogenic effects detected on small-cell lung carcinoma (SCLC) cell lines could be transposed on primary SCLC, the aim of the present work was to identify mediators of these mitogenic actions on primary tumours samples. This was addressed on normal human lung tissue, on SCLC and on non-SCLC (NSCLC). Herein, we observe, in normal human lung, that OTR is colocalized with vascular endothelial cells of the lung and is not expressed by lung cells of epithelial nature. We detected mRNA amplification of V1aR, V2R and of a V2R variant. We observed that 86% of SCLC biopsies analyzed expressed at least the OTR and that 71% expressed the OTR, the V1aR and the V2R altogether. Comparatively, 50% of NSCLC biopsies tested expressed at least the OTR and 32% expressed the OTR, the V1aR and the V2R altogether. The occurrence of the V1bR/V3R is of 28 and 18% for SCLC and NSCLC, respectively. Nevertheless, for the SCLC biopsies analyzed in this study, V1bR/V3R expression correlates, in all cases, with the expression of all the other neurohypophysial peptide receptors. Our results suggest that neurohypophysial peptide antagonists may offer promise as a potential new therapeutic modality for the treatment of lung cancer expressing at least one of the neurhypophysial peptide receptor subtypes. (c) 2005 Elsevier Ireland Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 23 (1 ULg)
Full Text
Peer Reviewed
See detailPoly(ethylene-co-vinyl acetate)/clay nanocomposites: Effect of clay nature and organic modifiers on morphology, mechanical and thermal properties
Peeterbroeck, Sophie; Alexandre, Michaël ULg; Jérôme, Robert ULg et al

in Polymer Degradation & Stability (2005), 90(2), 288-294

Nanocomposites based on an ethylene vinyl acetate copolymer (27 wt% vinyl acetate) and various (organo-modified) clays have been prepared by melt blending and their morphology, tensile and thermal ... [more ▼]

Nanocomposites based on an ethylene vinyl acetate copolymer (27 wt% vinyl acetate) and various (organo-modified) clays have been prepared by melt blending and their morphology, tensile and thermal degradation properties have been evaluated. Special attention has been paid to the influence of the clay nature and origin (montmorillonite or fluoromica) as well as on the nature of the ammonium cation organic modifier. It has been shown that nanostructure and tensile properties mainly depend on the nature of the organic modifier while the delay in thermal volatilisation of EVA during thermo-oxidation is mainly driven by the nature of the clay (mainly its aspect ratio), with no significant influence of the nanostructure of the nature of the organic modifier. (c) 2005 Elsevier Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 93 (6 ULg)
Full Text
Peer Reviewed
See detailPrecambrian geodynamics and ore formation: The Fennoscandian Shield
Weihed, Pär; Arndt, Nicholas; Billström, Kjell et al

in Ore Geology Reviews (2005), 27(1-4), 273-322

Compared with present-day global plate tectonics, Archaean and Palaeoproterozoic plate tectonics may have involved faster moving, hotter plates that accumulated less sediment and contained a thinner ... [more ▼]

Compared with present-day global plate tectonics, Archaean and Palaeoproterozoic plate tectonics may have involved faster moving, hotter plates that accumulated less sediment and contained a thinner section of lithospheric mantle. This scenario also fits with the complex geodynamic evolution of the Fennoscandian Shield from 2.06 to 1.78 Ga when rapid accretion of island arcs and several microcontinent-continent collisions in a complex array of orogens was manifested in short-lived but intense orogenies involving voluminous magmatism. With a few exceptions, all major ore deposits formed in specific tectonic settings between 2.06 and 1.78 Ga and thus a strong geodynamic control oil ore deposit formation is suggested. All orogenic gold deposits formed syn- to post-peak metamorphism and their timing reflects the orogenic younging of the shield towards the SW and west. Most orogenic gold deposits formed during periods of crustal shortening with peaks at 2.72 to 2.67, 1.90 to 1.86 and 1.85 to 1.79 Ga. The ca. 2.5 to 2.4 Ga Ni-Cu PGE deposits formed both as part of layered igneous complexes and associated with mafic volcanism, in basins formed during rifling of the Archaean craton at ca. 2.5 to 2.4 Ga. Svecokarelian ca. 1.89 to 1.88 Ga Ni-Cu deposits are related to mafic-ultramafic rocks intruded along linear belts at the accretionary margins of microcratons. All major VMS deposits in the Fennoscandian Shield formed between 1.97 and 1.88 Ga, in extensional settings, prior to basin inversion and accretion. The oldest "Cyprus-type" deposits were obducted onto the Archaean continent during the onset of convergence. The Pyhasalmi VMS deposits formed at 1.93 to 1.91 Ga in primitive, bimodal arc complexes during extension of the arc. In contrast, the Skellefte VMS deposits are 20 to 30 million years younger and formed in a strongly extensional intra-arc region that developed on continental or mature arc crust. Deposits in the Bergslagen-Uusimaa belt are similar in age to the Skellefte deposits and formed in a microcraton that collided with the Karelian craton at ca. 1.88 to 1.87 Ga. The Bergslagen-Uusimaa belt is interpreted as an intra-continental, or continental margin back-arc, extensional region developed on older continental crust. Iron oxide-copper-gold (IOCG) deposits are diverse in style. At least the oldest mineralizing stages, at ca. 1.88 Ga, are coeval with calc-alkaline to monzonitic magmatism and coeval and possibly cogenetic subaerial volcanism more akin to continental arcs or to magmatic arcs inboard of the active subduction zone. Younger mineralization of similar style took place when S-type magmatism occurred at ca. 1.80 to 1.77 Ga during cratonization distal to the active N-S-trending subduction zone in the west. Possibly, interaction of magmatic fluids with evaporitic sequences in older rift sequences was important for ore formation. Finally, the large volumes of anorthositic magmas that characterize the Sveconorwegian Orogeny formed a major concentration of Ti in the SW part of the Sveconorwegian orogenic belt under granulite facies conditions, about 40 million years after the last regional deformation of the Sveconorwegian Orogeny, between ca. 930 and 920 Ma. (c) 2005 Elsevier B.V. All rights reserved. [less ▲]

Detailed reference viewed: 113 (5 ULg)
Full Text
Peer Reviewed
See detailPrevalence des differentes especes de Candida au niveau vaginal dans la region Liegeoise
Senterre, J. M.; Carpentier, Martine ULg; Foidart, Jean-Michel ULg

in Revue Médicale de Liège (2005), 60(11), 882-4

We calculated the prevalences of different yeast species isolated from more than 20,000 vulvovaginal specimens carried out at the CHR hospital in Liege. To assess the value of the observed relative ... [more ▼]

We calculated the prevalences of different yeast species isolated from more than 20,000 vulvovaginal specimens carried out at the CHR hospital in Liege. To assess the value of the observed relative frequencies, the culture results of 149 samples were confronted with those of a real-time PCR technique of fungal identification. With a prevalence close to 90%, Candida albicans remains the largely dominant species. In contrast with other teams, we observed no increase of the prevalences of Candida non-albicans species. [less ▲]

Detailed reference viewed: 251 (3 ULg)
Full Text
See detailEvidence for phase-locked X-ray variations from the colliding-wind massive binary Cyg OB2 #8A
De Becker, Michaël ULg; Rauw, Grégor ULg

in Rauw, G.; Nazé, Y.; Blomme, R. (Eds.) et al Massive Stars and High-Energy Emission in OB Associations (2005, November)

We report on preliminary results of a multi-observatory investigation of the X-ray emission from the massive colliding wind binary Cyg OB2 #8A (O6If + O5.5III(f)). On the basis of our new XMM-Newton-EPIC ... [more ▼]

We report on preliminary results of a multi-observatory investigation of the X-ray emission from the massive colliding wind binary Cyg OB2 #8A (O6If + O5.5III(f)). On the basis of our new XMM-Newton-EPIC observations, along with archive ASCA-SIS and ROSAT-PSPC data, we show strong evidence for a significant phase-locked variability of the X-ray emission from Cyg OB2 #8A with the period of 21.9 days determined by De Becker et al. (2004). These results lend further support to the colliding wind scenario that was already suggested by optical data (De Becker & Rauw 2005). We briefly discuss the behaviour of the X-ray emission from this binary system as a function of phase in the context of the colliding wind scenario. [less ▲]

Detailed reference viewed: 15 (4 ULg)
Full Text
See detailXMM-Newton observations of the Cyg OB2 association
Rauw, Grégor ULg; De Becker, Michaël ULg; Linder, Natacha ULg

in Massive Stars and High-Energy Emission in OB Associations (2005, November)

We present the first results of an observing campaign of the Cyg OB2 association with the XMM-Newton observatory. The brightest OB-type stars exhibit rather hard spectra suggesting that at least part of ... [more ▼]

We present the first results of an observing campaign of the Cyg OB2 association with the XMM-Newton observatory. The brightest OB-type stars exhibit rather hard spectra suggesting that at least part of their X-ray emission arises in a wind-wind interaction. The EPIC images reveal a large number of fainter X-ray sources most of which are probably low-mass pre-main sequence stars belonging to Cyg OB2. [less ▲]

Detailed reference viewed: 17 (1 ULg)
Full Text
See detailOn the multiplicity of the non-thermal radio emitters 9 Sgr and HD 168112
Rauw, Grégor ULg; Sana, H.; Gosset, Eric ULg et al

in Massive Stars and High-Energy Emission in OB Associations (2005, November)

We discuss the first results of our ongoing optical spectroscopic monitoring campaign of the two O-type stars 9 Sgr and HD 168112. Both objects display a non-thermal radio emission and were considered as ... [more ▼]

We discuss the first results of our ongoing optical spectroscopic monitoring campaign of the two O-type stars 9 Sgr and HD 168112. Both objects display a non-thermal radio emission and were considered as single stars. Based on a large set of high-resolution spectra, we find that 9 Sgr is clearly an eccentric SB2 binary with an orbital period of several years. On the other hand, no evidence for radial velocity variations attributable to binary motion is found in our spectra of HD 168112. [less ▲]

Detailed reference viewed: 20 (1 ULg)
Full Text
Peer Reviewed
See detailL'aide à l'arrêt du tabagisme : une nécessité
Delvaux, Muriel ULg; Etienne, Anne-Marie ULg; Bartsch, Pierre ULg et al

in Revue Médicale de Liège (2005), 60(11), 863-866

Today the smoker carries a risk of mortality 70% higher compared to the nonsmoker. In Belgium active smoking is indisputably the most important cause of avoidable death. In 2004 it appears that 27% of the ... [more ▼]

Today the smoker carries a risk of mortality 70% higher compared to the nonsmoker. In Belgium active smoking is indisputably the most important cause of avoidable death. In 2004 it appears that 27% of the belgian population was smoking. This review describes the comorbidity associated with active tobacco consumption and defines the concepts of dependence and smoking cessation. It also identifies the three factors which determine the success of smoking cessation, i.e. the degree of nicotinic dependence, the presence of anxio-depressive disorders and the importance of the motivation to the stop. [less ▲]

Detailed reference viewed: 108 (7 ULg)
Full Text
See detailLa bibliothèque virtuelle de Google
Renaville, François ULg

Article for general public (2005)

Detailed reference viewed: 187 (63 ULg)
Full Text
Peer Reviewed
See detailHepatitis C infection: eligibility for antiviral therapies
Delwaide, Jean ULg; El Saouda, R.; Gerard, Christiane ULg et al

in European Journal of Gastroenterology & Hepatology (2005), 17(11), 1185-1189

Background Current treatments of chronic hepatitis C virus (HCV) are effective, but expensive and susceptible to induce significant side effects. Objectives To evaluate the proportion of HCV patients who ... [more ▼]

Background Current treatments of chronic hepatitis C virus (HCV) are effective, but expensive and susceptible to induce significant side effects. Objectives To evaluate the proportion of HCV patients who are eligible for a treatment. Methods In a database comprising 1726 viraemic HCV patients, the files of 299 patients who presented to the same hepatologist for an initial appointment between 1996 and 2003 were reviewed. Results Patients' characteristics were age 43.1 +/- 15.6 years, 53% male and 92% Caucasian. The main risk factors were transfusion (43%) and drug use (22%). Genotypes were mostly genotype 1 (66%), genotype 3 (12%) and genotype 2 (10%). These characteristics were not different from those of the whole series of 1726 patients. A total of 176 patients (59%) were not treated, the reasons for non-treatment being medical contraindications (34%), non-compliance (25%) and normal transaminases (24%). In addition, 17% of patients declined therapy despite being considered as eligible, mainly due to fear of adverse events. Medical contraindications were psychiatric (27%), age (22%), end-stage liver disease (15%), willingness for pregnancy (13%), cardiac contraindication (7%) and others (16%). Only 123 patients (41%) were treated. A sustained viral response was observed in 41%. The treatment was interrupted in 16% for adverse events. Conclusions The majority of HCV patients are not eligible for treatment. This implies that, with current therapies, only 17% of patients referred for chronic HCV become sustained responders. Some modifications of guidelines could extend the rate of treatment (patients with normal transaminases), but an important barrier remains the patients' and the doctors' fear of adverse events. [less ▲]

Detailed reference viewed: 25 (5 ULg)
Full Text
See detailBiotechnological application of Yarrowia lipolytica for biotransformation in biphasic media
Gomes, N.; Aguedo, Mario ULg; Teixeira, J.A. et al

in Livro de actas do Congresso MICROBIOTEC’2005 (2005, November)

Detailed reference viewed: 9 (1 ULg)
Full Text
Peer Reviewed
See detailA method based on multiple adaptive windows to improve the determination of disparity maps
Demoulin, Cédric; Van Droogenbroeck, Marc ULg

in ProRISC/IEEE Workshop on Circuit, Systems and Signal Processing (2005, November)

The correspondence problem is one of main topics in stereo vision that, despites being studied for many years, is still in progress. In this paper, we present a new method that computes the disparity map ... [more ▼]

The correspondence problem is one of main topics in stereo vision that, despites being studied for many years, is still in progress. In this paper, we present a new method that computes the disparity map. Our method is local (i.e. only information gathered in the close neighborhood is used) and is based on image statistics. More specifically it combines multiple adaptive windows and local statistical measures in order to optimize the quality of the computation of disparity maps. As the size of windows is critical for local methods, we propose an algorithm that modifies the size of windows surrounding the pixel of interest to capture enough information in regions with low texture energy. This process is based on statistical measures (mean and horizontal/vertical average deviation) taken in the windows of the original stereo images. In the last section we show that our method performs very well compared to other existing local methods. [less ▲]

Detailed reference viewed: 51 (2 ULg)
Full Text
Peer Reviewed
See detailInterfollicular fibrosis and organohalogens in the thyroid of the harbour porpoise (phocoena phocoena) of the British and Belgian coasts
Schnitzler, Joseph ULg; Das, Krishna ULg; Beineke, Andreas et al

Conference (2005, October 27)

Previous studies have described high levels of polychlorobiphenyls (PCB), p,p`-dichlordiphenyl-dichlorethen (DDT), p,p`-dichlordiphenyl-trichlorethan (DDE) and polybrominated diphenylether (PBDE) in the ... [more ▼]

Previous studies have described high levels of polychlorobiphenyls (PCB), p,p`-dichlordiphenyl-dichlorethen (DDT), p,p`-dichlordiphenyl-trichlorethan (DDE) and polybrominated diphenylether (PBDE) in the blubber of the harbour porpoise (Phocoena phocoena) from the North Sea raising the question of a potential endocrine disruption in this species. In the present study, the thyroids of 36 harbour porpoises from the British and the Belgian coast have been collected for histological and immunohistological investigations. The number and mean diameter of follicles and the relative distribution of follicular, connective and vascular tissues (%) were quantified in the thyroid of each individual. Then, the relationship between the thyroid morphometry data and previously described organic compounds (namely PCB, DDT, DDE and PBDE) was investigated using factor analysis and multiple regressions. The results of this work were compared to the previous study of harbour porpoises from the German (North and Baltic Seas), Norwegian and Icelandic coasts. Thyroid morphology was similar between the harbour porpoises from the British and Belgian coast. Compared to the previous study, the thyroids differed strongly between sampling sites. Porpoises from the German (North and Baltic Seas) and Norwegian coasts displayed a high percentage of connective tissues between 30 and 38% revealing severe inter-follicular fibrosis. The thyroids of Icelandic coasts displayed only a light inter-follicular fibrosis (percentage of connective tissue of 3%). The thyroids of the porpoises from the British and Belgian coasts occupied an intermediary place with a moderate fibrosis (percentage of connective tissue of 10%). A relation between mean diameter of follicles and the body size and mass suggesting a downward trend of activity of the thyroid with increasing body size and mass and thus, the age of the porpoises. A correlation-based principal component analysis (PCA) revealed one principal components explaining 69% of the total variance. The variables PCB, PBDE, DDT, and DDE compounds loaded highest on PC1. Our results pointed out a relationship between PCBs, PBDE, DDE and DDT (PC1) compounds and interfollicular fibrosis in the thyroids of harbour porpoises from the German coast of the Baltic Sea. The present report supports the hypothesis of a contaminant-induced thyroid fibrosis in harbour porpoises raising the question of the long term-viability in highly polluted areas [less ▲]

Detailed reference viewed: 25 (2 ULg)
Full Text
Peer Reviewed
See detailPseudomembranous colitis with Clostridium difficile during treatment by moxifloxacine (quinolone)
Le Goff, Caroline ULg; Wiesen, Patricia ULg; Collette, Julien ULg et al

Poster (2005, October 27)

C. difficile is the most frequently pathogenic agent isolated in colitis associated with antibiotics and pseudomembranous colitis (PMC). C. difficile takes advantage of the disturbance of the intestinal ... [more ▼]

C. difficile is the most frequently pathogenic agent isolated in colitis associated with antibiotics and pseudomembranous colitis (PMC). C. difficile takes advantage of the disturbance of the intestinal flora to settle. We report a case of PMC appeared during treatment with moxifloxacine in a pulmonary infection in an emphysematous patient. The diarrhea is generally benign, but can be severe, with toxic megacolon or even the extreme case of colic perforation. The diagnosis is based on the research of toxins of C. difficile (A and/or B) in the intestinal stools or liquids (collected at the time of the endoscopic examination) to which is associated the anaerobic culture on selective agar. The reference method is the measurement of the cytotoxic effect of the B-toxin on a cell culture. Metronidazole or vancomycine constitutes the treatment. The prevention of relapses is very important, hygiene measures and probiotic agents must be associated to the antibiotic treatment. [less ▲]

Detailed reference viewed: 75 (25 ULg)
Full Text
Peer Reviewed
See detailAntimicrobial activity of polyestyrene particles coated by photo-crooslinked block copolymers containing a biocidal polymethacrylate block
Lenoir, Sandrine ULg; Pagnoulle, Christophe; Detrembleur, Christophe ULg et al

in e-Polymers (2005), 74

A commercially available poly(ethylene-co-butylene) copolymer, end-capped by a short polyisoprene block and a hydroxyl group (PI-b-PEB-OH), has been derivatized into a macroinitiator for atom transfer ... [more ▼]

A commercially available poly(ethylene-co-butylene) copolymer, end-capped by a short polyisoprene block and a hydroxyl group (PI-b-PEB-OH), has been derivatized into a macroinitiator for atom transfer radical polymerization (ATRP) by esterification of the hydroxyl end-group by an activated bromide-containing acyl bromide. Two types of triblock copolymers, Pl-b-PEB-b-poly(dimethylaminoethyl methacrylate) (PDMAEMA) and Pl-b-PEB-b-poly[2-(tert-butylamino)ethyl methacrylate] (PTBAEMA), have been synthesized and used to coat polystyrene particles. These coatings have been permanently immobilized by UV cross-linking of the isoprene units. They exhibit a biocidal activity against Gram-negative bacteria either intrinsically in case of the PTBAEMA block or upon quaternization of the PDMAEMA block by octyl bromide. The antimicrobial activity is directly related to the concentration of coated PS particles in the medium. [less ▲]

Detailed reference viewed: 97 (5 ULg)
Full Text
See detailLe poids des morts
Ozer, Pierre ULg; Von Frenckell, Marianne ULg

Article for general public (2005)

Quand le Pakistan se prive d'un outil précieux d'aide à sa population sinistrée, pour préserver des intérêts militaires... [...] Avec l'objectif d'atténuer les répercussions de catastrophes d'origine ... [more ▼]

Quand le Pakistan se prive d'un outil précieux d'aide à sa population sinistrée, pour préserver des intérêts militaires... [...] Avec l'objectif d'atténuer les répercussions de catastrophes d'origine naturelle ou humaine sur la vie des gens et la propriété, la Charte internationale «Espace et catastrophes majeures» a été créée fin 2000. Son objectif est de délivrer gratuitement, via Internet, des données satellites en temps quasi réel permettant d'identifier les zones touchées par ces désastres. Ces documents sont de plus en plus souvent utilisés pour orienter les équipes de secouristes qui oeuvrent sur le terrain. [...] [less ▲]

Detailed reference viewed: 62 (11 ULg)