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See detailThe HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer
Crisanti, Cecilia; Wallace, Africa; Kapoor, Veena et al

in Molecular Cancer Therapeutics (2009), 8(8), 2221-2231

Lung cancer is the leading cause of cancer deaths in the United States. Current therapies are inadequate. Histone deacetylase inhibitors (HDACi) are a recently developed class of anticancer agents that ... [more ▼]

Lung cancer is the leading cause of cancer deaths in the United States. Current therapies are inadequate. Histone deacetylase inhibitors (HDACi) are a recently developed class of anticancer agents that cause increased acetylation of core histones and nonhistone proteins leading to modulation of gene expression and protein activityin - volved in cancer cell growth and survival pathways. We examined the efficacyof the HDACi panobinostat (LBH589) in a wide range of lung cancers and mesotheliomas. Panobinostat was cytotoxic in almost all 37 cancer cell lines tested. IC50 and LD50 values were in the low nmol/L range (4–470 nmol/L; median, 20 nmol/L). Small cell lung cancer (SCLC) cell lines were among the most sensitive lines, with LD50 values consistently <25 nmol/L. In lung cancer and mesothelioma animal models, panobinostat significantlyde creased tumor growth byan average of 62% when compared with vehicle control. Panobinostat was equallye ffective in immunocompetent and severe combined immunodeficiencymic e, indicating that the inhibition of tumor growth by panobinostat was not due to direct immunologic effects.Panobinostat was, however, particularlyeffective in SCLC xenografts, and the addition of the chemotherapyag ent etoposide augmented antitumor effects. Protein analysis of treated tumor biopsies revealed elevated amounts of cell cycle regulators such as p21 and proapoptosis factors, such as caspase 3 and 7 and cleaved poly[ADP-ribose] polymerase, coupled with decreased levels of antiapoptotic factors such as Bcl-2 and Bcl-XL. These studies together suggest that panobinostat maybe a useful adjunct in the treatment of thoracic malignancies, especiallySCLC. [less ▲]

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See detailAnchors of morphological operators and algebraic openings
Van Droogenbroeck, Marc ULg

in Hawkes, Peter (Ed.) Advances in Imaging and Electron Physics (2009)

Opening and closing operators play an important role in the field of mathematical morphology, mainly because of their useful property of idempotence, which is similar to the notion of ideal filter in ... [more ▼]

Opening and closing operators play an important role in the field of mathematical morphology, mainly because of their useful property of idempotence, which is similar to the notion of ideal filter in linear filtering. From a theoretical point of view, the study of openings has focused on the algebraic characterization of the operators themselves. Morphological filters have been studied for more than 30 years; the effects of the first filters (erosions, openings, and so on) are known in depth. In discussing the effects of a filter, it is not only the operator that is studied but also its relationship with the processed function or image and, in the particular case of mathematical morphology, the structuring element. In addition, there are several approaches to this analysis. For example, the analysis can consider the whole function or some subparts of the function, as in Van Droogenbroeck and Buckley (2005), who introduced the notion of morphological anchors. Anchors were defined in the context of morphological openings, as defined by the cascade of an erosion followed by a dilation. The extension to other kinds of openings is not straightforward. Despite the fact that all morphological openings induce the appearance of anchors, some opening operators (like the quantization opening defined in this chapter) might have no anchors. This chapter presents the theory of anchors related to morphological erosions and openings, and establishes some properties for the extended scope of algebraic openings. It is shown under which circumstances anchors exist for algebraic openings and how to locate some anchors; for example, it suffices for an opening to be spatial or shift-invariant to guarantee the existence of anchors. As for morphological openings, the existence of anchors may help clarify some algorithms or lead to new algorithms to compute algebraic openings. [less ▲]

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See detailNetwork Virtualization Architecture: Proposal and Initial Prototype
Schaffrath, Gregor; Werle, Christoph; Papadimitriou, Panagiotis et al

in ACM SIGCOMM Workshops Proceedings (2009, August)

The tussle between reliability and functionality of the Internet is firmly biased on the side of reliability. New enabling technologies fail to achieve traction across the majority of ISPs. We believe ... [more ▼]

The tussle between reliability and functionality of the Internet is firmly biased on the side of reliability. New enabling technologies fail to achieve traction across the majority of ISPs. We believe that the greatest challenge is not in finding solutions and improvements to the Internet's many problems, but in how to actually deploy those solutions and re-balance the tussle between reliability and functionality. Network virtualization provides a promising approach to enable the coexistence of innovation and reliability. We describe a network virtualization architecture as a technology for enabling Internet innovation. This architecture is motivated from both business and technical perspectives and comprises four main players. In order to gain insight about its viability, we also evaluate some of its components based on experimental results from a prototype implementation. [less ▲]

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See detailWide-area Detection of Voltage Instability from Synchronized Phasor Measurements. Part I: Principle
Glavic, Mevludin; Van Cutsem, Thierry ULg

in IEEE Transactions on Power Systems (2009), 24(3), 1408-1416

This two-part paper deals with the early detection of an impending voltage instability from the system states provided by synchronized phasor measurements. Recognizing that voltage instability detection ... [more ▼]

This two-part paper deals with the early detection of an impending voltage instability from the system states provided by synchronized phasor measurements. Recognizing that voltage instability detection requires assessing a multi-dimensional system, the method fits a set of algebraic equations to the sampled states, and performs an efficient sensitivity computation in order to identify when a combination of load powers has passed through a maximum. The important effects of overexcitation limiters are accounted for. The approach does not require any load model. This first part of the paper is devoted to theoretical foundations of sensitivity calculation along the system trajectory, derivation of the algebraic model, and illustration on a simple 5-bus system involving the long-term dynamics of a load tap changer and a field current limiter. [less ▲]

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See detailCertified Internet Coordinates
Kaafar, Mohamed Ali; Mathy, Laurent ULg; Barakat, Chadi et al

in ICCCN '09 Proceedings (2009, August)

We address the issue of asserting the accuracy of coordinates advertised by nodes of Internet coordinate systems during distance estimations. Indeed, some nodes may lie deliberately about their ... [more ▼]

We address the issue of asserting the accuracy of coordinates advertised by nodes of Internet coordinate systems during distance estimations. Indeed, some nodes may lie deliberately about their coordinates to mount various attacks against applications and overlays. Our proposed method consists in two steps: 1) establish the correctness of a node’s claimed coordinate (which leverages our previous work on securing the coordinates embedding phase using a Surveyor infrastructure); and 2) issue a time limited validity certificate for each verified coordinate. Validity periods are computed based on an analysis of coordinate inter-shift times observed on PlanetLab, and shown to follow a long-tail distribution (lognormal distribution in most cases, or Weibull distribution otherwise). The effectiveness of the coordinate certification method is validated by measuring the impact of a variety of attacks on distance estimates. [less ▲]

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See detailWide-area Detection of Voltage Instability from Synchronized Phasor Measurements. Part II: Simulation results
Glavic, Mevludin; Van Cutsem, Thierry ULg

in IEEE Transactions on Power Systems (2009), 24(3), 1417-1425

This two-part paper deals with the early detection of an impending voltage instability from the system states provided by synchronized phasor measurements. Recognizing that voltage instability detection ... [more ▼]

This two-part paper deals with the early detection of an impending voltage instability from the system states provided by synchronized phasor measurements. Recognizing that voltage instability detection requires assessing a multidimensional system, the method fits a set of algebraic equations to the sampled states, and performs an efficient sensitivity in order to identify when a combination of load powers has passed through a maximum. This second part of the paper presents simulation results obtained from detailed time-domain simulation of the Nordic32 test system, without and with measurement noise, respectively. Several practical improvements are described such as anticipation of overexcitation limiter activation, and use of a moving average filter. Robustness to load behaviour, non updated topology and unobservability is also shown. Finally a comparison with Thevenin impedance matching criterion is provided. [less ▲]

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See detailInnovations in Navigation Lock Design
Rigo, Philippe ULg; INCOM WG29

Book published by PIANC - Report 106 - 2009 (2009)

State of art in navigation locks , focuss on innovations

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See detailPrenatal diagnosis of benign extreme hyperlordosis.
Chantraine, Frédéric ULg; Tutschek, Boris; Senterre, Thibault ULg et al

in Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine (2009), 28(8), 1097

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See detailGeometric Study of Mixed-integer Sets from Two Rows of Two Adjacent Simplex Bases
Louveaux, Quentin ULg

Conference (2009, August)

We generalize the study of sets arising from two rows of a simplex tableau by considering bounds on the nonbasic variables. We show that new classes of facets arise that cannot be obtained from triangles ... [more ▼]

We generalize the study of sets arising from two rows of a simplex tableau by considering bounds on the nonbasic variables. We show that new classes of facets arise that cannot be obtained from triangles and quadrilaterals. Specifically, when exactly one upper bound on a non-basic variable is introduced, inequalities that can be derived from pentagons involving up to six variables also appear. [less ▲]

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See detailHiggs Exclusive Production
Dechambre, Alice ULg

Poster (2009, August)

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See detailPractical Methods for Measuring the Tortuosity of Porous Materials from Binary or Gray-Tone Tomographic Reconstructions
Gommes, Cédric ULg; Bons, Anton-Jan; Blacher, Silvia ULg et al

in AIChE Journal (2009), 55(8), 2000-2012

Two practical methods are proposed to measure the tortuosity of a porous or permeable material from its tomographic reconstruction. The first method is based on the direct measurement of the shortest ... [more ▼]

Two practical methods are proposed to measure the tortuosity of a porous or permeable material from its tomographic reconstruction. The first method is based on the direct measurement of the shortest distance between two points in the pores, and the second is based on the geodesic reconstruction of the pore or permeation space. Unlike the first method, the second can be directly applied to gray-tone tomograms, without the need of a segmentation step. The methods are illustrated with an electron tomogram of clay/plastic nanocomposite, an X-ray microtomogram of sandstone, and a series of model morphologies consisting of penetrable random spheres. For the latter series, the measured tortuosities compare very well with those derived independently from the theoretical effective diffusion coefficients [less ▲]

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See detailPotential of Dried Egg Yolk as a Source of Immunoglobulins to Control Salmonella in the Gastrointestinal Tract of the Broiler Chicken
Marcq, Christopher ULg; Portetelle, Daniel ULg; Chalghoumi, RAJA ULg et al

in 17th European Symposium on Poultry Nutrition : Proceedings & Abstracts (2009, August)

Egg yolk immunoglobulins (IgY) are considered as a promising tool of establishing passive immunity against enteric pathogens (e.g. Salmonella) in poultry (Kovacs-Nolan and Mine, 2005). In our previous ... [more ▼]

Egg yolk immunoglobulins (IgY) are considered as a promising tool of establishing passive immunity against enteric pathogens (e.g. Salmonella) in poultry (Kovacs-Nolan and Mine, 2005). In our previous works, in-feed incorporation of freeze-dried yolk powder (FYP) improved performances of Salmonella-infected broilers (Marcq et al., 2009). Nevertheless, no extra value could be attributed to the presence of specific IgY when a comparison was done between impact of hyperimmune or non immune FYP both concerning growth performances and Salmonella infection. We hypothesized that these inconclusive in vivo results were related to the sensitivity of IgY to gastrointestinal conditions. Egg yolks with high IgY titers directed against Salmonella Enteritidis and Typhimurium were obtained from laying hens immunized as previously described (Chalghoumi et al., 2008). Three feed additives derived from these eggs were produced: FYP, spray-dried yolk powder (SYP), and freeze-dried water-soluble fraction of yolk powder (WSFP). A force-feeding assay was realized on these additives with 48 five-week-old males Ross broiler chicken (Salmonella spp.-free status). Survival of undigested IgY and bioactive Fab fragments was evaluated in the intestinal tract by ELISA. Statistical analyses were done using GLM procedure of Minitab 15.1. Software. Differences were considered significant when P<0.05. As a result of the digestive process, the levels of total and specific undigested IgY found throughout the intestine were dramatically reduced for the three additives. For FYP, no difference was observed with intestinal contents of control animals (P>0.05) and for WSFP, which correspond to semi-purified IgY, the immunological activity reached the same level than that for SYP (P>0.05) whereas its initial level was almost ten times higher. The results suggest a protective effect of whole yolk on IgY with SYP but such effect was not observed with FYP. High levels of Fab fragments were identified in intestinal contents, highlighting the importance of protein digestion in the digestive tract and especially pepsin digestion. These Fab fragments conserve their immunological functionality and remained detectable in all intestinal segments including the caecum which represents the major site of Salmonella infection in poultry. These results can explain our previous challenge data and reveal that a protection treatment should be applied to dried egg yolk to improve the resistance of IgY to gastrointestinal conditions in broilers. [less ▲]

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See detailCrystal plasticity prediction of Lankford coefficient using the MULTISITE model: influence of the critical resolved shear stresses
Hammami, Walid ULg; Delannay, Laurent; Duchene, Laurent ULg et al

in International Journal of Material Forming (2009, August), 2(Supplément 1), 65-68

The MULTISITE model [1] is based on polycrystalline plasticity and the underlying hypotheses of the model are (i) that the deformation of each grain is significantly influenced by the interaction with a ... [more ▼]

The MULTISITE model [1] is based on polycrystalline plasticity and the underlying hypotheses of the model are (i) that the deformation of each grain is significantly influenced by the interaction with a limited number of adjacent grains, and (ii) that local strains deviate from their macroscopic average according to specific “relaxation modes”. The LAMEL model [2] is reformulated into the more general elastic-viscoplastic MULTISITE model permitting various relaxation modes. This model has been validated for cubic materials but hexagonal close-packed (HCP) crystals usually demonstrate larger anisotropy than cubic crystals. The model was used to simulate uniaxial tensile tests performed on rolled sheets made of Ti-6Al-4V. The Lankford coefficients (r) calculated in various directions in the plane of the sheet were analysed. In this study, different grain interaction hypotheses were tested. Besides, it appeared that the value of the critical resolved shear stresses (CRSS) of the different slip system families of the HCP metal had significant effects on the results. Their influence as well as the influence of the strain rate sensitivity parameter was examined. [less ▲]

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See detailTransfer of heroin profiling method from conventional GC-MS to Fast-GC-MS and UHPLC-MS/MS
Debrus, Benjamin ULg; Broséus, Julian; Guillarme, Davy et al

Conference (2009, August)

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See detailGenetic evaluation considering phenotypic data and limited molecular information using a novel equivalent model: Case study using effect of the mh locus on milk production in the dual-purpose Belgian Blue breed
Colinet, Frédéric ULg; Gengler, Nicolas ULg

Conference (2009, August)

The introduction of molecular information into genetic evaluation systems is currently under research. Based on an equivalent method, we developed from existing theory a new alternative strategy for the ... [more ▼]

The introduction of molecular information into genetic evaluation systems is currently under research. Based on an equivalent method, we developed from existing theory a new alternative strategy for the prediction of gene effects and especially their smooth integration into genetic evaluations. Underlying hypothesis were based on the idea that knowledge of genotypes will not affect overall additive genetic variance but only change expected values of genetic effects for animals with known genotypes. However, all animals could not be genotyped. Thus, the developed equations were modified to allow the integration of the known genotype for a portion of the population. This strategy was tested for the mh locus (responsible for the double-muscling phenotype) in dual-purpose Belgian Blue cattle. The genotype was determined for 123 bulls and 1940 cows (+/+ 19.5, mh/+ 39.3 and mh/mh 41.2%). These animals had 11,150 daughters with test-day (TD) records. The genotypes were incorporated into a modified genetic evaluation based on the current routine multi-trait multibreed test-day model used in the Walloon Region (Belgium). Data used included 12,829,309 TD records for 689,057 dairy cows in production. The pedigree file contained 1,606,024 animals (cows with TD records and ancestors). Computation of the modified mixed model equations was done solving iteratively two systems of equations, one for the polygenic effects and one for the gene effect until the relative differences in the gene solutions were below 10-5. A linear extrapolation was also used to speed up the convergence of gene effects. As expected, the mh locus exerts negative effects on milk production traits. For the first three lactations, the average estimated allelic substitution effects were -158.7 kg milk, -8.93 kg fat and -5.64 kg protein per lactation (305 days). [less ▲]

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