Publications ORBi OA
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See detailIs the neutrophil a worthy target in severe asthma and chronic obstructive pulmonary disease?
Louis, Renaud ULg; Djukanovic, R.

in Clinical & Experimental Allergy : Journal of the British Society for Allergy & Clinical Immunology (2006), 36(5), 563-567

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See detailConcurrent coronary and carotid artery surgery: an open debate: reply
Kolh, Philippe ULg; Limet, Raymond ULg

in European Heart Journal (2006), 27(10), 1259-1260

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See detailDiarrhea induced by high doses of nicotinamide in dialysis patients
Delanaye, Pierre ULg; Weekers, Laurent ULg; Krzesinski, Jean-Marie ULg

in Kidney International (2006), 69(10), 1914-1914

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See detailTranscription impairment and cell migration defects in elongator-depleted cells: Implication for familial dysautonomia
Close, Pierre ULg; Hawkes, Nicola; Cornez, Isabelle ULg et al

in Molecular Cell (2006), 22(4), 521-531

Mutations in IKBKAP, encoding a subunit of Elongator, cause familial dysautonomia (FD), a severe neuro-developmental disease with complex clinical characteristics. Elongator was previously linked not only ... [more ▼]

Mutations in IKBKAP, encoding a subunit of Elongator, cause familial dysautonomia (FD), a severe neuro-developmental disease with complex clinical characteristics. Elongator was previously linked not only with transcriptional elongation and histone acetylation but also with other cellular processes. Here, we used RNA interference (RNAi) and fibroblasts from FD patients to identify Elongator target genes and study the role of Elongator in transcription. Strikingly, whereas Elongator is recruited to both target and nontarget genes, only target genes display histone H3 hypoacetylation and progressively lower RNAPII density through the coding region in FD cells. Interestingly, several target genes encode proteins implicated in cell motility. Indeed, characterization of IKAP/hELP1 RNAi cells, FD fibroblasts, and neuronal cell-derived cells uncovered defects in this cellular function upon Elongator depletion. These results indicate that defects in Elongator function affect transcriptional elongation of several genes and that the ensuing cell motility deficiencies may underlie the neuropathology of FD patients. [less ▲]

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See detailRaloxifene-induced myeloma cell apoptosis: a study of nuclear factor-kappaB inhibition and gene expression signature.
Olivier, Sabine ULg; Close, Pierre ULg; Castermans, Emilie ULg et al

in Molecular Pharmacology (2006), 69(5), 1615-1623

Because multiple myeloma remains associated with a poor prognosis, novel drugs targeting specific signaling pathways are needed. The efficacy of selective estrogen receptor modulators for the treatment of ... [more ▼]

Because multiple myeloma remains associated with a poor prognosis, novel drugs targeting specific signaling pathways are needed. The efficacy of selective estrogen receptor modulators for the treatment of multiple myeloma is not well documented. In the present report, we studied the antitumor activity of raloxifene, a selective estrogen receptor modulator, on multiple myeloma cell lines. Raloxifene effects were assessed by tetrazolium salt reduction assay, cell cycle analysis, and Western blotting. Mobility shift assay, immunoprecipitation, chromatin immunoprecipitation assay, and gene expression profiling were performed to characterize the mechanisms of raloxifene-induced activity. Indeed, raloxifene, as well as tamoxifen, decreased JJN-3 and U266 myeloma cell viability and induced caspase-dependent apoptosis. Raloxifene and tamoxifen also increased the cytotoxic response to vincristine and arsenic trioxide. Moreover, raloxifene inhibited constitutive nuclear factor-kappaB (NF-kappaB) activity in myeloma cells by removing p65 from its binding sites through estrogen receptor alpha interaction with p65. It is noteworthy that microarray analysis showed that raloxifene treatment decreased the expression of known NF-kappaB-regulated genes involved in myeloma cell survival and myeloma-induced bone lesions (e.g., c-myc, mip-1alpha, hgf, pac1,...) and induced the expression of a subset of genes regulating cellular cycle (e.g., p21, gadd34, cyclin G2,...). In conclusion, raloxifene induces myeloma cell cycle arrest and apoptosis partly through NF-kappaB-dependent mechanisms. These findings also provide a transcriptional profile of raloxifene treatment on multiple myeloma cells, offering the framework for future studies of selective estrogen receptor modulators therapy in multiple myeloma. [less ▲]

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See detailRéforme de Bologne : quelles transformations de l’évaluation des apprentissages ?
Gorga, Adriana; Charlier, Bernadette; Gilles, Jean-Luc ULg

Conference (2006, May)

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See detail2006, International Year of Deserts, Desertification and Dust
Ozer, Pierre ULg; Courel, Marie-Françoise; Goudie, Andrew S

in Africa Health (2006), 28(4), 3

Desertification ranks among the major environmental challenges of the 21st century and is defined by the United Nations Convention to Combat Desertification as ‘land degradation in arid, semiarid, and dry ... [more ▼]

Desertification ranks among the major environmental challenges of the 21st century and is defined by the United Nations Convention to Combat Desertification as ‘land degradation in arid, semiarid, and dry subhumid areas resulting from various factors, including climatic variations and human activities’. Currently, desertification affects a total area between 6 million and 12 million square kilometres and generates large loss of income, estimated at US$42 billion each year. Areas threatened by desertification occupy 34% of the Earth’s land area and are home to about 2 billion people. [...] [less ▲]

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See detailPhonological deficits in French speaking children with SLI
Maillart, Christelle ULg; Parisse, Christophe

in International Journal of Language & Communication Disorders (2006), 41(3), 253274

Background: This study investigated the phonological disorders of Frenchspeaking children with specific language impairment (SLI) in production. Aims: The main goal was to confirm whether children with ... [more ▼]

Background: This study investigated the phonological disorders of Frenchspeaking children with specific language impairment (SLI) in production. Aims: The main goal was to confirm whether children with SLI have limitations in phonological ability as compared with normally developing children matched by mean length of utterance (MLU) and phonemic inventory size. A number of researchers have obtained findings pointing in this direction, but the conclusions have never been tested on French-speaking children. The second goal was to find out whether characteristic features of the French language are reflected in the nature of the children’s phonological disorder. Methods & Procedures: The spontaneous language of 16 children with SLI and 16 control children matched on MLU and phonemic inventory size (normal language development group) were analysed using different measures bearing on utterances, words, syllables and phonemes. In both SLI and NLD groups, the children were distributed into two different subgroups based on their MLU, with controlled phonemic inventory size. Outcomes & Results: The results supported a specific limitation in the phonological abilities of French children with SLI, as has already been demonstrated for English, Hebrew, Italian and Spanish-Catalan. However, two unexpected results were also obtained. First, a significant difference between children with SLI and control children could only be found for older children (MLU.3), not for younger children with MLU,3. This was true for all measures. Conclusions: This finding highlights the importance of having a developmental perspective and needs to be confirmed through a longitudinal study. Second, deficits were much more significant at the phoneme level than at the syllable level. This may be explained by the fact that the pronunciation of syllables in French is very homogenous, making them easier to segment. [less ▲]

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See detailEarlier onset of tumoral anglogenesis in matrix metalloproteinase-19-deficient mice
Jost, M.; Folgueras, A. R.; Frerart, F. et al

in Cancer Research (2006), 66(10), 5234-5241

Among matrix metalloproteinases (MMP), MMP-19 displays unique structural features and tissue distribution. In contrast to most MMPs, MMP-19 is expressed in normal human epidermis and down-regulated during ... [more ▼]

Among matrix metalloproteinases (MMP), MMP-19 displays unique structural features and tissue distribution. In contrast to most MMPs, MMP-19 is expressed in normal human epidermis and down-regulated during malignant transformation and dedifferentiation. The contribution of MMP-19 during tumor angiogenesis is presently unknown. In an attempt to give new insights into MMP-19 in vivo functions, angiogenic response of mutant mice lacking MMP-19 was analyzed after transplantation of murine malignant PDVA keratinocytes and after injection of Matrigel supplemented with basic fibroblast growth factor. In situ hybridization and immunohistochemical analysis revealed that MMP-19 is produced by host mesenchymal cells but not by endothelial capillary cells or CD11b-positive inflammatory cells. Based on a new computer-assisted method of quantification, we provide evidence that host MMP-19 deficiency was associated with an increased early angiogenic response. In addition, increased tumor invasion was observed in MMP-19-/- mice. We conclude that, in contrast to most MMPs that promote tumor progression, MMP-19 is a negative regulator of early steps of tumor angiogenesis and invasion. These data highlight the requirement to understand the individual functions of each MMP to improve anticancer strategies. [less ▲]

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See detailStress, coffe drink, tobacco and alcohol consumption in a student sample of smokers
Delvaux, Muriel ULg

Poster (2006, May)

Emotional responses to stress play an important role in health behavior change. During times of low and high academic demands, health behaviors tend to be deteriorated in college undergraduate students ... [more ▼]

Emotional responses to stress play an important role in health behavior change. During times of low and high academic demands, health behaviors tend to be deteriorated in college undergraduate students (Weidner et al., 1996). A similar study found increasing anxiety and smoking behaviors, but a decrease in the consumption of alcohol during the examination period in medical students (Ogden & Mtandabari, 1997). In current smokers, mean score on Perceived Stress Scale is significantly higher than that of the students who don’t smoke (Naquin & Gilbert, 1996). [less ▲]

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See detailTabagisme et dépression
Delvaux, Muriel ULg

Poster (2006, May)

Les épisodes dépressifs majeurs sont plus fréquents parmi les fumeurs (6,6 %) que les non -fumeurs (2,9%).Il y a une proportion significativement plus importante de sujets étant ou ayant été à un moment ... [more ▼]

Les épisodes dépressifs majeurs sont plus fréquents parmi les fumeurs (6,6 %) que les non -fumeurs (2,9%).Il y a une proportion significativement plus importante de sujets étant ou ayant été à un moment de leur vie fumeurs, parmi les sujets présentant des antécédents de dépression (76%) que parmi les sujets indemnes de tels antécédents (52%). Enfin, les fumeurs ayant des antécédents de dépression (prévalence sur la vie entière) ont significativement moins de chances de s’arrêter de fumer (14%) que les sujets sans antécédents dépressifs (28%) (Martinet & Bohadana, 1997). La relation entre tabagisme et dépression semble être bidirectionnelle. Cette étude tente d’établir un lien entre dépression et dépendance à la nicotine dans une population de fumeurs liégeois tout-venant, et compare le taux de dépression entre les genres d’une part, entre les fumeurs et des non-fumeurs appariés d’autre part. [less ▲]

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See detailComposition chimique des graines de pin d'Alep (Pinus halepensis Mill.) d'origine tunisienne et caracterisation de la fraction lipidique.
Cheikh Rouhou, S.; Hentati, B.; Besbes, Souhail et al

Poster (2006, May)

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See detailSelective coil occlusion of a large arterioportal fistula in a liver graft
Detry, Olivier ULg; De Roover, Arnaud ULg; Delwaide, Jean ULg et al

in Liver Transplantation (2006), 12(5), 888-889

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See detailEmergency graft removal after liver transplantation
Detry, Olivier ULg; De Roover, Arnaud ULg; Delwaide, Jean ULg et al

in Liver Transplantation (2006, May), 12(5), 72

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See detailFrance and NATO : between political distrust and doctrinal rapprochement
Dumoulin, André ULg

in Revue Défense Nationale (2006), (686),

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See detailPesticide residues in ACP countries: Hwo the process of harmonizing regulations on pesticide residues in EU ca affect crop protocols in ACP countries
Schiffers, Bruno ULg

in Abstracts 58th International Symposium on Crop Protection (2006, May)

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See detailExploration of the neural substrates of executive functioning by functional neuroimaging
Collette, Fabienne ULg; Hogge, Michaël; Salmon, Eric ULg et al

in Neuroscience (2006), 139(1), 209-221

This review presents neuroimaging studies that have explored the cerebral substrates of executive functioning. These studies have demonstrated that different executive functions not only recruit various ... [more ▼]

This review presents neuroimaging studies that have explored the cerebral substrates of executive functioning. These studies have demonstrated that different executive functions not only recruit various frontal areas but also depend upon posterior (mainly parietal) regions. These results are in accordance with the hypothesis that executive functioning relies on a distributed cerebral network that is not restricted to anterior cerebral areas. However, there exists an important heterogeneity in the cerebral areas associated with these different processes, and also between different tasks assessing the same process. Since these discrepant results could be due to the paradigms used (subtraction designs), recent results obtained with conjunction and interaction analyses are presented, which confirm the role of parietal areas in executive functioning and also demonstrate the existence of some specificity in the neural substrates of the executive processes of updating, shifting and inhibition. Finally, functional magnetic resonance imaging studies show that the activity in cerebral areas involved in executive tasks can be transient or sustained. Consequently, to better characterize the functional role of areas associated with executive functioning, it is important to take into account not only the localization of cerebral activity but also the temporal pattern of this activity. [less ▲]

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