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See detailThe epileptic syndromes with continuous spikes and waves during slow sleep: definition and management guidelines.
Van Bogaert, P.; Aeby, A.; De Borchgrave, V. et al

in Acta Neurologica Belgica (2006), 106(2), 52-60

The authors propose to define the epileptic syndromes with continuous spikes and waves during slow sleep (CSWS) as a cognitive or behavioral impairment acquired during childhood, associated with a strong ... [more ▼]

The authors propose to define the epileptic syndromes with continuous spikes and waves during slow sleep (CSWS) as a cognitive or behavioral impairment acquired during childhood, associated with a strong activation of the interictal epileptiform discharges during NREM sleep--whatever focal or generalized--and not related to another factor than the presence of CSWS. The type of syndrome will be defined according to the neurological and neuropsychological deficit. These syndromes have to be classified among the localization-related epileptic syndromes. Some cases are idiopathic and others are symptomatic. Guidelines for work-up and treatment are proposed. [less ▲]

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See detailPatient Preference in the Management of Postmenopausal Osteoporosis with Bisphosphonates
Reginster, Jean-Yves ULg; Rabenda, Véronique ULg

in Clinical Interventions in Aging (2006), 1(4), 415-23

The leading treatments for postmenopausal osteoporosis are the nitrogen-containing bisphosphonates, which are required long term for optimal benefit. Oral bisphosphonates have proven efficacy in ... [more ▼]

The leading treatments for postmenopausal osteoporosis are the nitrogen-containing bisphosphonates, which are required long term for optimal benefit. Oral bisphosphonates have proven efficacy in postmenopausal osteoporosis in clinical trials, but in practice the therapeutic benefits are often compromised by patients' low adherence. Nonadherence to bisphosphonate therapy negatively impacts outcomes such as fracture rate; fractures are in turn associated with decreased quality of life. The most common reason cited by patients for their nonadherence is that the strict dosing instructions for bisphosphonates are difficult to follow. One aspect of bisphosphonate administration that can be changed is dosing frequency and several studies have evaluated patient preferences for different dosing schedules. Studies have shown a preference for a weekly bisphosphonate regimen versus daily dosing and it has been demonstrated that this preference for reduced dosing frequency impacts on adherence. Ibandronate is the first nitrogen-containing oral bisphosphonate for osteoporosis that can be administered in a monthly regimen and two robust clinical studies demonstrated a strong patient preference for this monthly regimen versus a weekly regimen. It is important that physicians consider patient preference when prescribing treatment for osteoporosis to ensure that the disease is effectively managed for the long-term benefit of the patient. [less ▲]

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See detailPhysiopathologie de l'hyperglycemie post-prandiale
Scheen, A. J.; Paquot, Nicolas ULg

in Journées Annuelles de Diabetologie de l'Hôtel-Dieu (2006)

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See detailLe travail de modélisation aux prises avec l'exigence démocratique : le projet PEPAM et les conditions d'un apprentissage croisé entre experts et citoyens
Melard, François ULg

in Sciences et expertises en société - Actes du colloque "Les savoirs au défi de la Paix et de la Citoyennté (2006)

La construction d’un outil de gestion implique tout à la fois des connaissances, des anticipations, des choix sur les pratiques qu’elles visent à gérer. Dans le cas de la gestion des risques liés à ... [more ▼]

La construction d’un outil de gestion implique tout à la fois des connaissances, des anticipations, des choix sur les pratiques qu’elles visent à gérer. Dans le cas de la gestion des risques liés à l’usage des pesticides en Belgique, un « outil scientifique » (sous la forme d’un modèle et de ses indicateurs) est mobilisé et transformé afin de participer à une politique publique de diminution des risques. Les experts et modélisateurs d’un institut de recherche publique ont proposé - avec l’aide de chercheurs en sciences humaines - d’ouvrir à la discussion au sein d’un panel de citoyens la pertinence de la construction et de l’usage de leur modèle. Par cette situation expérimentale, plusieurs intérêts peuvent être poursuivis : évaluer la capacité de citoyens à apprendre et à s’approprier une thématique complexe et technique et à faire des propositions visant à « améliorer », voire à « dépasser » le fonctionnement dudit modèle ; mais aussi et surtout à étudier les conditions par lesquelles les experts eux-mêmes peuvent apprendre des remarques et suggestions de citoyens concernant leur pratique. C’est de ce double enjeu qu’est né le projet PEPAM. Cette présente communication vise à rendre compte de ses principaux enseignements lorsqu’ils touchent la question de la construction participative et démocratique d’outils scientifiques et de gestion dans le domaine environnemental. [less ▲]

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See detailBabels du 21e siècle. Quelques notes sur la traduction française d’un poème de Leonard Schwartz
Pagnoulle, Christine ULg

in Palimpsestes (2006), HS

How a French translation can convey the puns and sound effects that are integral in this grim epic on reprisals, this sensual ode to love.

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See detailAnalytic properties of unitarization schemes
Selyugin, Oleg Viktorovich; Cudell, Jean-René ULg

in Czechoslovak Journal of Physics (2006)

The analytic properties of the elastic hadron scattering amplitude are examined in the impact parameter representation at high energies. Different unitarization procedures and the corresponding non-linear ... [more ▼]

The analytic properties of the elastic hadron scattering amplitude are examined in the impact parameter representation at high energies. Different unitarization procedures and the corresponding non-linear equations are presented. Several unitarisation schemes are presented. They lead to almost identical results at the LHC. [less ▲]

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See detailAn exploration of the relationships between short-term memory for serial order information, item information and new word learning in adults
Majerus, Steve ULg; Poncelet, Martine ULg; Elsen, B. et al

in European Journal of Cognitive Psychology (2006), 18(6), 848-873

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See detailAnalysis of kinetic energy release distributions by the maximum entropy method.
Leyh, Bernard ULg; Gridelet, E.; Locht, Robert ULg et al

in International Journal of Mass Spectrometry (2006), 249-250

Energy is not always fully randomized in an activated molecule because of the existence of dynamical constraints. An analysis of kinetic energy release distributions (KERDs) of dissociation fragments by ... [more ▼]

Energy is not always fully randomized in an activated molecule because of the existence of dynamical constraints. An analysis of kinetic energy release distributions (KERDs) of dissociation fragments by the maximum entropy method (MEM) provides information on the efficiency of the energy flow between the reaction coordinate and the remaining degrees of freedom during the fragmentation. For example, for barrierless cleavages, large translational energy releases are disfavoured while energy channeling into the rotational and vibrational degrees of freedom of the pair of fragments is increased with respect to a purely statistical partitioning. Hydrogen atom loss reactions provide an exception to this propensity rule. An ergodicity index, F, can be derived. It represents an upper bound to the ratio between two volumes of phase space: that effectively explored during the reaction and that in principle available at the internal energy E. The function F(E) has been found to initially decrease and to level off at high internal energies. For an atom loss reaction, the orbiting transition state version of phase space theory (OTST) is especially valid for low internal energies, low total angular momentum, large reduced mass of the pair of fragments, large rotational constant of the fragment ion, and large polarizability of the released atom. For barrierless dissociations, the major constraint that results from conservation of angular momentum is a propensity to confine the translational motion to a two-dimensional space. For high rotational quantum numbers, the influence of conservation of angular momentum cannot be separated from effects resulting from the curvature of the reaction path. The nonlinear relationship between the average translational energy <epsilon > and the internal energy E is determined by the density of vibrational-rotational states of the pair of fragments and also by non-statistical effects related to the incompleteness of phase space exploration. The MEM analysis of experimental KERDs suggests that many simple reactions can be described by the reaction path Hamiltonian (RPH) model and provides a criterion for the validity of this method. Chemically oriented problems can also be solved by this approach. A few examples are discussed: determination of branching ratios between competitive channels, reactions involving a reverse activation barrier, nonadiabatic mechanisms, and isolated state decay. (c) 2005 Elsevier B.V. All rights reserved. [less ▲]

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See detailAnalytical validation of the new plasma calibrated Accu-Chek (R) Test Strips (Roche Diagnostics)
Meex, Cécile ULg; Poncin, José ULg; Chapelle, Jean-Paul ULg et al

in Clinical Chemistry & Laboratory Medicine (2006), 44(11), 1376-1378

Background: The Accu-Chek Inform glucose monitor is a point-of-care system for testing blood glucose. New test strips, calibrated to deliver glucose plasma-like values, were launched on the market in May ... [more ▼]

Background: The Accu-Chek Inform glucose monitor is a point-of-care system for testing blood glucose. New test strips, calibrated to deliver glucose plasma-like values, were launched on the market in May 2005. The aim of our study was to perform analytical validation of these new strips. Methods: We compared the new plasma strips with whole blood strips; results for the plasma strips with plasma values obtained using a clinical analyzer and with whole blood values given by the glucose electrode of a blood gas analyzer; and the influence of the type of blood (capillary or venous) on the results obtained by the glucose monitor with the plasma calibrated strips. Results: Plasma strips give on average 7% higher results than the previous whole blood strips. However, the results given by the plasma strips on capillary whole blood, even if well correlated, are not completely comparable with those given by an analyzer for venous plasma. Nevertheless, these plasma strips and the glucose electrode of a blood gas analyzer give comparable results. Conclusions: Accu-Chek Inform plasma strips are a good method for monitoring of blood glucose values in patients with diabetes. [less ▲]

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See detailAttitude à adopter devant une pression artérielle chroniquement basse
Grosch, Stéphanie ULg; Maillet, J.; Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (2006), 61(5-6, May-Jun), 374-9

Chronic arterial hypotension has been poorly studied. Its mechanisms are not well understood; its treatment (if needed) is disappointing, without any demonstrated improvement of symptoms or prognosis ... [more ▼]

Chronic arterial hypotension has been poorly studied. Its mechanisms are not well understood; its treatment (if needed) is disappointing, without any demonstrated improvement of symptoms or prognosis. Thus, a complete medical examination is needed to exclude any organic cause. If none is found, it is important to reassure the patient and to convince him not to use expensive drugs potentially generative of side effects. [less ▲]

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See detailA-t-on evalue l'interet du SAMU?
Bodson, Lucien ULg; Grenade, J.; Micheels, Jean ULg et al

in Revue Médicale de Liège (2006), 61(5-6, May-Jun), 494-9

Recent international guidelines about emergency situations (ILCOR / ERC) pointed to the need of the whole "chain of survival". ALS, Advanced Life Support (the last and "medical" part of the chain ) is ... [more ▼]

Recent international guidelines about emergency situations (ILCOR / ERC) pointed to the need of the whole "chain of survival". ALS, Advanced Life Support (the last and "medical" part of the chain ) is important and influences survival rate. If no doubt exists about "what" and "when" to do in such situations, there is no consensus in industrialized countries about "who" should be in charge of such out-of-hospital acute diagnosis and treatment: emergency physicians, emergency nurses, emergency medical technicians (EMT), other "new" professionals ? ... A description of the MICU system in Belgium is given. [less ▲]

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See detailChange blindness to gradual changes in facial expressions
David, E.; Laloyaux, Cédric ULg; Devue, Christel ULg et al

in Psychologica Belgica (2006), 46(4), 253-268

Change blindness—our inability to detect changes in a stimulus—occurs even when the change takes place gradually, without disruption (Simons et al., 2000). Such gradual changes are more difficult to ... [more ▼]

Change blindness—our inability to detect changes in a stimulus—occurs even when the change takes place gradually, without disruption (Simons et al., 2000). Such gradual changes are more difficult to detect than changes that involve a disruption. In this experiment, we extend previous findings to the domain of facial expressions of emotions occurring in the context of a realistic scene. Even with changes occurring in central, highly relevant stimuli such as faces, gradual changes still produced high levels of change blindness: Detection rates were three times lower for gradual changes than for displays involving disruption, with only 15% of the observers perceiving the gradual change within a single trial. However, despite this high rate of change blindness, changes on faces were significantly better detected than color changes occurring on non facial objects in the same scene. [less ▲]

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See detailEffect of rimonabant on quality of life in overweight/obese patients
Kolotkin, R. L.; Crosby, R. D.; Scheen, André ULg et al

in Value in Health (2006), 9(3, MAY-JUN), 92

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See detailElevated MMP-12 protein levels in induced sputum from patients with COPD
Demedts, Inge K.; Morel-Montero, A.; Lebecque, S. et al

in Thorax (2006), 61(3), 196-201

Background: Several matrix metalloproteinases ( MMPs) are involved in the pathogenesis of chronic obstructive pulmonary disease ( COPD). In mice, MMP-12 plays a crucial role in the development of ... [more ▼]

Background: Several matrix metalloproteinases ( MMPs) are involved in the pathogenesis of chronic obstructive pulmonary disease ( COPD). In mice, MMP-12 plays a crucial role in the development of cigarette smoke induced emphysema. A study was undertaken to investigate the role of MMP-12 in the development of COPD in human smokers. Methods: Induced sputum samples were collected from patients with stable COPD (n = 28), healthy smokers ( n = 14), never smokers ( n = 20), and former smokers ( n = 14). MMP-12 protein levels in induced sputum were determined by ELISA and compared between the four study groups. MMP-12 enzymatic activity in induced sputum was evaluated by casein zymography and by cleaving of a fluorescence quenched substrate. Results: Median (IQR) MMP-12 levels were significantly higher in COPD patients than in healthy smokers, never smokers, and former smokers (17.5 (7.1 - 42.1) v 6.7 (3.9 - 10.4) v 4.2 (2.4 - 11.3) v 6.1 (4.5 - 7.6) ng/ml, p = 0.0002). MMP-12 enzymatic activity was significantly higher in patients with COPD than in controls (4.11 (1.4 - 8.0) v 0.14 (0.1 - 0.2) mu g/ml, p = 0.0002). Conclusion: MMP-12 is markedly increased in induced sputum from patients with stable COPD compared with controls, suggesting a role for MMP-12 in the development of COPD in smokers. [less ▲]

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See detailDes outils pour concevoir et réguler des dispositifs d'apprentissage autonome hybrides ou à distance
Denis, Brigitte ULg

in Faciliter les apprentissages autonomes, 7e colloque européen sur l'autoformation, Toulouse (2006)

L’auteur propose différents modèles ou outils d’analyse qui supportent la conception de dispositifs de formation recourant aux TIC et favorisant des apprentissages autonomes. Elle met plus ... [more ▼]

L’auteur propose différents modèles ou outils d’analyse qui supportent la conception de dispositifs de formation recourant aux TIC et favorisant des apprentissages autonomes. Elle met plus particulièrement en relation le lien entre certaines facettes du « modèle » du DIAMANT et la tenue d’un carnet de bord par es apprenants. Elle illustre ensuite son approche en prenant l’exemple du dispositif d’apprentissage collaboratif à distance Learn-Nett. Son analyse se focalise sur les facettes suivantes du dispositif de formation : caractéristiques des apprenants, compétences (prérequises et à acquérir), préparation technologique et à la collaboration à distance, options épistémologiques et méthodes de formation, rapport réflexif sur le vécu du processus d’apprentissage basé sur le carnet de bord tenu par les apprenants. [less ▲]

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See detailEditorial du numéro consacré aux compétences
Lafontaine, Dominique ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2006), 21-22

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See detailElectrochemical study of two tris-O-substituted calix[4]arenes: 25,27-dipropoxy-26-hydroxy-28-benzoyloxycalix[4]arene(partial cone) and 25,27-dibenzyl-26-hydroxy-28-benzoyloxy-calix[4]-arene (partial cone). Electro synthesis of the corresponding calix[4]arene-monoquinones
Louati, Alain; Spraula, Julien; Gabelica, Valérie ULg et al

in Electrochemistry Communications (2006), 8(5), 761-766

The anodic oxidation of 25,27-dipropoxy-26-hydroxy-28-benzoyloxycalix[4]arene 1 and 25,27-dibenzyl-26-hydroxy-28-benzoyloxycalix[4]arene 2 in dichloromethane was investigated by electrochemical and ... [more ▼]

The anodic oxidation of 25,27-dipropoxy-26-hydroxy-28-benzoyloxycalix[4]arene 1 and 25,27-dibenzyl-26-hydroxy-28-benzoyloxycalix[4]arene 2 in dichloromethane was investigated by electrochemical and spectroclectrochemical techniques. For both, the overall reaction is a two-electron oxidation of the phenolic group according to an ECE mechanism resulting in the ultimate formation of an observable phenoxylium cation. After reaction of the latter with traces of water and subsequent internal electron transfer, the corresponding calix[4]-monoquinones are formed. (c) 2006 Elsevier B.V. All rights reserved. [less ▲]

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See detailGemvid, an Open Source, Modular, Automated Activity Recording System for Rats Using Digital Video
Poirrier, Jean-Etienne; Poirrier, Laurent; Leprince, Pierre ULg et al

in Journal of Circadian Rhythms (2006), 4

BACKGROUND: Measurement of locomotor activity is a valuable tool for analysing factors influencing behaviour and for investigating brain function. Several methods have been described in the literature for ... [more ▼]

BACKGROUND: Measurement of locomotor activity is a valuable tool for analysing factors influencing behaviour and for investigating brain function. Several methods have been described in the literature for measuring the amount of animal movement but most are flawed or expensive. Here, we describe an open source, modular, low-cost, user-friendly, highly sensitive, non-invasive system that records all the movements of a rat in its cage. METHODS: Our activity monitoring system quantifies overall free movements of rodents without any markers, using a commercially available CCTV and a newly designed motion detection software developed on a GNU/Linux-operating computer. The operating principle is that the amount of overall movement of an object can be expressed by the difference in total area occupied by the object in two consecutive picture frames. The application is based on software modules that allow the system to be used in a high-throughput workflow. Documentation, example files, source code and binary files can be freely downloaded from the project website at http://bioinformatics.org/gemvid/. RESULTS: In a series of experiments with objects of pre-defined oscillation frequencies and movements, we documented the sensitivity, reproducibility and stability of our system. We also compared data obtained with our system and data obtained with an Actiwatch device. Finally, to validate the system, results obtained from the automated observation of 6 rats during 7 days in a regular light cycle are presented and are accompanied by a stability test. The validity of this system is further demonstrated through the observation of 2 rats in constant dark conditions that displayed the expected free running of their circadian rhythm. CONCLUSION: The present study describes a system that relies on video frame differences to automatically quantify overall free movements of a rodent without any markers. It allows the monitoring of rats in their own environment for an extended period of time. By using a low-cost, open source hardware/software solution, laboratories can greatly simplify their data acquisition and analysis pipelines and improve their workload. [less ▲]

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See detailLe questionnaire d'interaction Travail-Famille de Nijmegen : resultats preliminaires et interet pour la clinique
Hansez, Isabelle ULg; Etienne, Anne-Marie ULg; Geurts, S.

in Revue Francophone de Clinique Comportementale et Cognitive (2006), 11(2), 1-13

The first purpose of this paper was to analyse the psychometric properties of the French version of the most frequently used survey for measuring work-home interaction, i.e. the Survey Work-home ... [more ▼]

The first purpose of this paper was to analyse the psychometric properties of the French version of the most frequently used survey for measuring work-home interaction, i.e. the Survey Work-home Interaction – Nijmegen (SWING). The second purpose was to determine the direction of influence (with an origin in one domain – work or home- and an impact in the other domain) and the quality of impact (being positive or negative). The third objective was to check the consistency of the scores across relevant sub-groups such as gender and working time. Three cross-sectional surveys (in total, N=254) were conducted. The French version of the SWING, including 24 items, presents acceptable internal consistency and reliability coefficients. The direction of work-home interaction shows a positive impact of work in the family domain. Finally there is some evidence for relevant gender and working time effects. The clinical interest of this questionnaire is also discussed. [less ▲]

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See detailInsulin Detemir in the Treatment of Type 1 and Type 2 Diabetes
Philips, J. C.; Scheen, André ULg

in Vascular Health and Risk Management (2006), 2(3), 277-83

Insulin detemir is a soluble long-acting human insulin analogue at neutral pH with a unique mechanism of action. Following subcutaneous injection, insulin detemir binds to albumin via fatty acid chain ... [more ▼]

Insulin detemir is a soluble long-acting human insulin analogue at neutral pH with a unique mechanism of action. Following subcutaneous injection, insulin detemir binds to albumin via fatty acid chain, thereby providing slow absorption and a prolonged metabolic effect. Insulin detemir has a less variable pharmacokinetic profile than insulin suspension isophane or insulin ultralente. The use of insulin detemir can reduce the risk of hypoglycemia (especially nocturnal hypoglycemia) in type 1 and type 2 diabetic patients. However, overall glycemic control, as assessed by glycated hemoglobin, is only marginally and not significantly improved compared with usual insulin therapy. The weight gain commonly associated with insulin therapy is rather limited when insulin detemir is used. In our experience, this new insulin analogue is preferably administrated at bedtime but can be proposed twice a day (in the morning and either before the dinner or at bedtime). Detemir is a promising option for basal insulin therapy in type 1 or type 2 diabetic patients. [less ▲]

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