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See detailLa passe et le témoin. Une épistémologie pour la sémiotique
Badir, Sémir ULg

Scientific conference (2004, April 23)

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See detailLes Paradoxes de l'Autonomie
Stassart, Martine ULg

Conference given outside the academic context (2004)

How is it possible for an adolescent to become autonomous in spite of the necessity to introject some qualities of the others (parents, teachers and so on).

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See detailHow to introduce "Geography" into databases?
Donnay, Jean-Paul ULg

Scientific conference (2004, April 21)

Form and content of spatial data. Geographic versus cartographic data? Software solutions: mapping software, Desktop GIS, Enterprise GIS. Database models: Flat relational, Spatial-enabled database ... [more ▼]

Form and content of spatial data. Geographic versus cartographic data? Software solutions: mapping software, Desktop GIS, Enterprise GIS. Database models: Flat relational, Spatial-enabled database. Required standards. GIS architecture today. [less ▲]

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See detailElectrochemical formation of polypyrrole nanowires
Jérôme, Christine ULg; Labaye, David; Jérôme, Robert ULg

in Synthetic Metals (2004), 142(1-3), 207-216

This paper aims at approaching the mechanism of formation of polypyrrole (PPy) nanowires by an all-electrochemical process, which consists in electrografting a poly(alkylacrylate) film onto the surface of ... [more ▼]

This paper aims at approaching the mechanism of formation of polypyrrole (PPy) nanowires by an all-electrochemical process, which consists in electrografting a poly(alkylacrylate) film onto the surface of a cathode, followed by the anodic electropolymerization of pyrrole (Py) at the surface of this organomodified electrode. The experimental conditions for the pyrrole oxidation, including solvent and concentrations of monomer and supporting electrolyte, have been changed with the purpose to tune the characteristic features of the polypyrrole nanowires. The polyacrylate template has also been modified, all other conditions being the same, in an effort to design the shape and size of the wires. The electrochemical behavior of the as-prepared PPy wires has been characterized. [less ▲]

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See detailNafion-layered silicate nanocomposite membrane for fuel cell application
Thomassin, Jean-Michel ULg; Pagnoulle, Christophe; Bizzari, Didier et al

in e-Polymers (2004), (18), 1-13

Direct methanol fuel cells (DMFCs) using a proton exchange membrane as electrolyte is an attractive option for electricity generation. The most widely used membrane in the DMFC system is based on a ... [more ▼]

Direct methanol fuel cells (DMFCs) using a proton exchange membrane as electrolyte is an attractive option for electricity generation. The most widely used membrane in the DMFC system is based on a perfluorinated polymer bearing sulfonic acid functions like Nafion®. The latter combines chemical, mechanical and thermal stability and high protonic conductivity but shows elevated methanol permeability. We propose the preparation of a novel type of hybrid membranes to tentatively solve this problem. This innovative material results from the homogeneous dispersion of a nano-scaled inorganic filler within Nafion. The filler consists of stacks of negatively charged alumino-silicate layers (Cloisite), with a positive counter-ion in the interlamellar space. The purpose of the addition of this filler is to decrease methanol diffusion through the polymer membrane without decreasing too much the ionic conductivity. [less ▲]

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See detailA tavola con la natura morta. Quando non resta che consumare il sacro
Dondero, Maria Giulia ULg

in Espressione/Contenuto : Rivista dell’Associazione Italiana di Studi Semiotici (2004, April 11)

Cet article étudie la relation intertextuelle et intersémiotique entre le genre de la nature morte entendue comme Vanitas et Memento mori, la tradition picturale de l’« Et in Arcadia Ego » et quelques ... [more ▼]

Cet article étudie la relation intertextuelle et intersémiotique entre le genre de la nature morte entendue comme Vanitas et Memento mori, la tradition picturale de l’« Et in Arcadia Ego » et quelques photos contemporaines. [less ▲]

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See detailMethod for producing functionalized alkoxyamine initiator and use thereof
Detrembleur, Christophe ULg; Gross, Thomas; Meyer, Rolf-Volker

Patent (2004)

PROBLEM TO BE SOLVED: To provide a method for producing a functionalized alkoxyamine initiator and its use in radical polymerization process. ; SOLUTION: The invention provides a one-pot process for the ... [more ▼]

PROBLEM TO BE SOLVED: To provide a method for producing a functionalized alkoxyamine initiator and its use in radical polymerization process. ; SOLUTION: The invention provides a one-pot process for the production of a functionalized alkoxyamine of general formula (I) (for example, R<SP>1</SP>and R<SP>2</SP>are each H; R<SP>3</SP>is phenyl; and R<SP>4</SP>and R<SP>5</SP>together with nitrogen atom form an alicyclic 6-membered ring). The method includes (1) the formation of an aqueous phase and nitroxyl radical by reacting an oxidizing agent with a secondary amine having steric hindrance and (2) the removal of the aqueous phase and the addition of one or more vinyl monomers to the nitroxyl radical according to the method and system for the production of the radical. The invention further provides a monomer polymerization method using the functionalized alkoxyamine. [less ▲]

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See detailRoles and competencies of the e-tutor
Denis, Brigitte ULg; Watland, Philip; Pirotte, Sébastien et al

in Banks, S.; Goodyear, P.; Hogdson, V. (Eds.) et al Networked learning 2004 : a research based conference on networked learning and lifelong learning : proceedings of the fourth international conference, Lancaster (2004, April 07)

This paper considers the roles and competencies of the e-tutor. A literature review shows that different roles are assigned to the online tutors. Definitions of these roles are presented and discussed ... [more ▼]

This paper considers the roles and competencies of the e-tutor. A literature review shows that different roles are assigned to the online tutors. Definitions of these roles are presented and discussed. Afterwards, we present eleven roles we consider important to manage the interactions between learners and tutors in an e-learning environment and the competencies needed to support these tutor’s roles. We conclude that to improve the quality of e-learning the tutor’s interventions have to be adapted to a specific context and we propose to train the e-tutors for these roles. [less ▲]

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See detailDevelopment of optical ground verification method for mu m to sub-mm reflectors
Stockman, Yvan ULg; Thizy, Cédric ULg; Lemaire, Philippe ULg et al

in Warmbein, B. (Ed.) Proceedings of the 5th International Conference on Space Optics (ICSO) (2004, April 02)

Large reflectors and antennas for the IR to mm wavelength range are being planned for many Earth observation and astronomical space missions and for commercial communication satellites as well. The ... [more ▼]

Large reflectors and antennas for the IR to mm wavelength range are being planned for many Earth observation and astronomical space missions and for commercial communication satellites as well. The challenging tasks of on-ground testing are to achieve the required accuracy in the measurement of the reflector shapes and antenna structures and to verify their performance under simulated space conditions (vacuum, low temperatures). A small number of infrared interferometers have been commercially developed over the last 10 years but their applications have also been limited due to poor dynamic range and the restricted spatial resolution of their detectors. It has therefore been considered essential, from the viewpoint of supporting future ESA exploration missions, to develop and realise suitable verification tools based on infrared interferometry and other optical techniques for testing large reflector structures, telescope configurations and their performances under simulated space conditions. Two methods and techniques are developed at CSL. The first one is an IR-phase shifting interferometer with high spatial resolution. This interferometer shall be used specifically for the verification of high precision IR, FIR and sub-mm reflector surfaces and telescopes under both ambient and thermal vacuum conditions. The second one presented hereafter is a holographic method for relative shape measurement. The holographic solution proposed makes use of a home built vacuum compatible holographic camera that allows displacement measurements from typically 20 nanometres to 25 microns in one shot. An iterative process allows the measurement of a total of up to several mm of deformation. Uniquely the system is designed to measure both specular and diffuse surfaces [less ▲]

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See detailUp-regulation of vascular endothelial growth factor-A by active membrane-type 1 matrix metalloproteinase through activation of Src-tyrosine kinases
Sounni, Nor Eddine ULg; Roghi, C.; Chabottaux, Vincent et al

in Journal of Biological Chemistry (2004), 279(14), 13564-13574

Membrane-type 1 matrix metalloproteinase (MT1-MMP) and vascular endothelial growth factor ( VEGF) are two key molecules involved in pericellular proteolysis and cell proliferation during tumor growth and ... [more ▼]

Membrane-type 1 matrix metalloproteinase (MT1-MMP) and vascular endothelial growth factor ( VEGF) are two key molecules involved in pericellular proteolysis and cell proliferation during tumor growth and angiogenesis. Our previous data showed that MT1-MMP overexpression in human breast carcinoma MCF7 cells induced an up-regulation of VEGF expression. This effect was associated in vivo with accelerated tumor growth and angiogenesis. We now provide evidence that MT1-MMP overexpression specifically affected VEGF-A production and failed to influence that of other VEGF family members ( VEGF, B, C, D, or PlGF) or their receptors. The up-regulation of VEGF-A by MT1-MMP was related to an increased transcriptional activation rather than to a modification of mRNA stability. It was blocked by synthetic MMP inhibitors, TIMP2, but not TIMP-1 and abolished by a partial deletion of the catalytic domain or the cytoplasmic tail of MT1-MMP. Analysis of the signal transduction mechanisms demonstrated that MT1-MMP acts through a signaling pathway involving Src tyrosine kinases. Thus, our results provide new insight into the mechanisms of action of MT1-MMP during angiogenesis and suggest that the full enzymatic activity of MT1-MMP is required for a specific up-regulation of VEGF-A through an activation of Src tyrosine kinase pathways. [less ▲]

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See detailRéforme, université et compétence
VIERSET, Viviane ULg

Learning material (2004)

Adaptation des objectifs de l’enseignement universitaire à une logique d’entreprise ? Mise en parallèle des objectifs-enjeux de l'enseignement et des objectifs-enjeux de l'entreprise : exemples de l ... [more ▼]

Adaptation des objectifs de l’enseignement universitaire à une logique d’entreprise ? Mise en parallèle des objectifs-enjeux de l'enseignement et des objectifs-enjeux de l'entreprise : exemples de l'enseignement supérieur au Maroc versus en CfWB. [less ▲]

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See detailToxicomanie: prise en charge du nouveau-né
Battisti, Oreste ULg

Scientific conference (2004, April 01)

présentation concernant la prise en charge globale du nouveau-né issu d'une pharmacodpéndnace

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See detailL'astronomie dans le monde
Manfroid, Jean ULg

Article for general public (2004)

Sedna; Galaxies lointaines; Anneaux de Neptune; Eau sur Mars

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See detailThyrotoxic adenoma followed by atypical hyperthyroidism due to struma ovarii: clinical and genetic studies
Ciccarelli, A.; Valdes Socin, Hernan Gonzalo ULg; Parma, J. et al

in European Journal of Endocrinology (2004), 150(4), 431-437

OBJECTIVE: Atypical forms of hyperthyroidism represent a diagnostic challenge for clinicians. Struma ovarii is an ovarian teratoma and constitutes a rare cause of ectopic thyroidal hormonal production. We ... [more ▼]

OBJECTIVE: Atypical forms of hyperthyroidism represent a diagnostic challenge for clinicians. Struma ovarii is an ovarian teratoma and constitutes a rare cause of ectopic thyroidal hormonal production. We describe a case of struma ovarii that combined two different sources of hyperthyroidism in the same patient and report genetic studies in order to contribute a better understanding of the autonomy and tumorigenesis of the struma ovarii. CASE REPORT: A 73-year-old nulliparous woman presented a thyroid toxic adenoma that was successfully treated with 10 mCi radioiodine. Unexpectedly, a new onset of hyperthyroidism prompted us to look for a second etiology. A whole-body scan with (123)I detected a pelvic hyperfixation suggesting struma ovarii, and a thyroid differentiated left ovarian teratoma 3 cm in size was surgically removed. We screened for mutations of thyroid-stimulating hormone receptor and Gs-alpha protein genes, as these mutations are common in thyroid adenomas. We did not identify any mutations. Androgen receptor study demonstrated a monoclonal status. Comparative genomic hybridization did not reveal any chromosomal abnormality. However, loss of heterozygosity analysis showed several structural abnormalities, compared with the majority of benign ovarian teratomas, which show a normal karyotype. CONCLUSIONS: This is the first well-documented report of thyrotoxic struma ovarii revealed after treatment of a single thyroid toxic adenoma. We have shown in this case that struma ovarii originates from a single germ cell, and, albeit benign, this tumor presents several chromosomal abnormalities. Struma ovarii-induced hyperthyroidism is likely to be mediated by mechanisms different from those of the classical thyroid toxic adenoma. [less ▲]

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See detailThe novel somatostatin analog SOM230 is a potent inhibitor of hormone release by growth hormone- and prolactin-secreting pituitary adenomas in vitro.
Hofland, Leo J; van der Hoek, Joost; van Koetsveld, Peter M et al

in Journal of Clinical Endocrinology and Metabolism (2004), 89(4), 1577-1585

To determine the inhibitory profile of the novel somatostatin (SRIF) analog SOM230 with broad SRIF receptor binding, we compared the in vitro effects of SOM230, octreotide (OCT), and SRIF-14 on hormone ... [more ▼]

To determine the inhibitory profile of the novel somatostatin (SRIF) analog SOM230 with broad SRIF receptor binding, we compared the in vitro effects of SOM230, octreotide (OCT), and SRIF-14 on hormone release by cultures of different types of secreting pituitary adenomas. OCT (10 nM) significantly inhibited GH release in seven of nine GH-secreting pituitary adenoma cultures (range, -26 to -73%), SOM230 (10 nM) in eight of nine cultures (range, -22 to -68%), and SRIF-14 (10 nM) in six of six cultures (range, -30 to -75%). The sst analysis showed predominant but variable levels of somatostatin receptor (sst)(2) and sst(5) mRNA expression. In one culture completely resistant to OCT, SOM230 and SRIF-14 significantly inhibited GH release in a dose-dependent manner with an IC(50) value in the low nanomolar range. In the other cultures, SOM230 showed a lower potency of GH release inhibition (IC(50), 0.5 nM), compared with OCT (IC(50), 0.02 nM) and SRIF-14 (IC(50), 0.02 nM). A positive correlation was found between sst(2) but not sst(5) mRNA levels in the adenoma cells and the inhibitory potency of OCT on GH release in vivo and in vitro, and the effects of SOM230 and SRIF-14 in vitro. In three prolactinoma cultures, 10 nM OCT weakly inhibited prolactin (PRL) release in only one (-28%), whereas 10 nM SOM230 significantly inhibited PRL release in three of three cultures (-23, -51, and -64.0%). The inhibition of PRL release by SOM230 was related to the expression level of sst(5) but not sst(2) mRNA. Several conclusions were reached. First, SOM230 has a broad profile of inhibition of tumoral pituitary hormone release in the low nanomolar range, probably mediated via both sst(2) and sst(5) receptors. The higher number of responders of GH-secreting pituitary adenoma cultures to SOM230, compared with OCT, suggest that SOM230 has the potency to increase the number of acromegalic patients which can be biochemically controlled. Second, compared with OCT, SOM230 is more potent in inhibiting PRL release by mixed GH/PRL-secreting adenoma and prolactinoma cells. [less ▲]

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See detailMatrix metalloproteinases and tissue inhibitors of matrix metalloproteinases mRNA transcripts in the bronchial secretions of asthmatics
Cataldo, Didier ULg; Guéders, Maud ULg; Munaut, Carine ULg et al

in Laboratory Investigation : Journal of Technical Methods & Pathology (2004), 84(4), 418-424

Asthma is a chronic inflammatory disease characterized by profound extracellular matrix changes referred to as bronchial remodelling. In this study, we evaluated matrix metalloproteinases (MMPs) and ... [more ▼]

Asthma is a chronic inflammatory disease characterized by profound extracellular matrix changes referred to as bronchial remodelling. In this study, we evaluated matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) mRNA expression in bronchial secretions of asthmatics and correlated MMPs modulations with the lung function as a reflection of the bronchial extracellular matrix remodelling. Quantitative RT-PCR was performed on cell pellets obtained from induced sputum in order to detect the mRNAs for MMP-1, -2, -3, -8, -9, -12, -13 TIMP-1, -2, while semiquantitative RT-PCR was performed to assess the expression of MMP-7, monocyte chemoattractant protein-1 (MCP-1) and transforming growth factor-beta(1) (TGF-beta(1)). The mRNA transcripts for MMP-1, TIMP-1 and monocyte chemoattractant protein-1 (MCP-1) were increased in cell pellets of induced sputum from asthmatics when compared to controls (P<0.05), and the intensity of MMP-1 mRNA expression inversely correlated with the FEV(1) in asthmatics (r=-0.49, P<0.05). The MMP-1 mRNA/TIMP-1 mRNA ratio correlated with the levels of MCP-1 mRNA in asthmatics (r=0.47, P<0.05). There were no differences between the groups with respect to mRNA coding for MMP-2, -3, -7, -8, -9, -12, -13, -14, TIMP-2 and TGF-beta(1). We conclude that cells contained in the bronchial secretions from asthmatics express higher amounts of mRNA for MMP-1 and TIMP-1, perhaps related to an increased expression of MCP-1, which might contribute to the extracellular matrix changes observed during airway remodelling. [less ▲]

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See detailFaut-il chasser les marchands du temple?
Debruyne, Guido; Van Droogenbroeck, Marc ULg

Article for general public (2004)

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See detailClimate change impacts on groundwater resources: modelled deficits in a chalky aquifer, Geer basin, Belgium
Brouyère, Serge ULg; Carabin, Guy; Dassargues, Alain ULg

in Hydrogeology Journal (2004), 12(2), 123-134

An integrated hydrological model (MOHISE) was developed in order to study the impact of climate change on the hydrological cycle in representative water basins in Belgium. This model considers most ... [more ▼]

An integrated hydrological model (MOHISE) was developed in order to study the impact of climate change on the hydrological cycle in representative water basins in Belgium. This model considers most hydrological processes in a physically consistent way, more particularly groundwater flows which are modelled using a spatially distributed, finite-element approach. Thanks to this accurate numerical tool, after detailed calibration and validation, quantitative interpretations can be drawn from the groundwater model results. Considering IPCC climate change scenarios, the integrated approach was applied to evaluate the impact of climate change on the water cycle in the Geer basin in Belgium. The groundwater model is described in detail, and results are discussed in terms of climate change impact on the evolution of groundwater levels and groundwater reserves. From the modelling application on the Geer basin, it appears that, on a pluriannual basis, most tested scenarios predict a decrease in groundwater levels and reserves in relation to variations in climatic conditions. However, for this aquifer, the tested scenarios show no enhancement of the seasonal changes in groundwater levels. [less ▲]

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See detailL'angor
Legrand, Victor ULg

in Revue Médicale de Liège (2004), 59(4), 186-9

The medical history is the cornerstone of the diagnosis of chest pain. In presence of angina like symptoms, the diagnosis of coronary artery disease must be assertained by rest and exercise ECG ... [more ▼]

The medical history is the cornerstone of the diagnosis of chest pain. In presence of angina like symptoms, the diagnosis of coronary artery disease must be assertained by rest and exercise ECG, eventually coupled with a stress echo or scintigraphy. Coronary angiography remains the ultimate diagnostic procedure despite recent advances in CT scan or MRI technologies. Beside symptomatic treatment aiming to reduce metabolic demand by medication or to improve revascularisation by surgery or percutaneous intervention, the actual therapeutic approach involves therapies aiming to stop atherosclerosis such as strict correction of coronary risk factors, use of statines, ACE inhibitors and antiplatelet agents. [less ▲]

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See detailLe General et le Physicien. Modalites de rupture des anevrysmes de l'aorte abdominale : du paroxysme a la crise differee
Limet, Raymond ULg

in Revue Médicale de Liège (2004), 59(4), 201-2

Abdominal aortic rupture is sometimes paroxystic. More often, the rupture process takes hours, even days. Surgical efficiency is dependant on an early diagnosis.

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