Publications ORBi OA
Bookmark and Share    
Full Text
Peer Reviewed
See detailLymphotoxin alpha gene in Crohn's disease patients: absence of implication in the response to infliximab in a large cohort study
Dideberg, Vinciane ULg; Louis, Edouard ULg; Farnir, Frédéric ULg et al

in Pharmacogenetics and Genomics (2006), 16(5), 369-373

A haplotype in the lymphotoxin alpha (LTA) gene has been associated with a lack of response to infliximab in a small cohort of Crohn's disease (CD) patients. The present study aimed to confirm the ... [more ▼]

A haplotype in the lymphotoxin alpha (LTA) gene has been associated with a lack of response to infliximab in a small cohort of Crohn's disease (CD) patients. The present study aimed to confirm the implication of this haplotype in the response to infliximab in a larger cohort of Caucasian patients. The response to the first infusion with infliximab was evaluated in 214 Caucasian patients with either luminal (n = 150) or fistulising (n = 64) CD. Clinical response was based on the decrease in CID Activity Index (luminal) or on the evolution in the fistula discharge (fistulising). Biological response was assessed in 139 patients who had elevated C-reactive protein (CRP) before treatment and for whom CRP values were also available after treatment. A positive biological response was defined as a decrease in CRP of at least 25%. The patients were genotyped for six polymorphisms in the LTA gene. A positive clinical response was present in 65.4% of the patients and a positive biological response was observed in 80.6% of the patients. No association was found with any of the studied polymorphisms, nor with the previously published LTA haplotype and the response to infliximab. We could not confirm an association between the LTA locus and clinical or biological response to infliximab in a large cohort of CID patients. Pharmacogenetics and Genomics 16:369-373 (c) 2006 Lippincott Williams [less ▲]

Detailed reference viewed: 38 (1 ULg)
Full Text
Peer Reviewed
See detailFully automated heart rate variability assessment in dairy cows
Janda, Jozef; Guyot, Hugues ULg; Sandersen, Charlotte ULg et al

in Acta Physiologica (2006, May), 187(Suppl 651), -16

Detailed reference viewed: 35 (6 ULg)
Full Text
Peer Reviewed
See detailDestruction of the main olfactory epithelium reduces female sexual behavior and olfactory investigation in female mice
Keller, Matthieu ULg; Douhard, Quentin ULg; Baum, M. J. et al

in Chemical Senses (2006), 31(4), 315-323

We studied the contribution of the main olfactory system to mate recognition and sexual behavior in female mice. Female mice received an intranasal irrigation of either a zinc sulfate (ZnSO4) solution to ... [more ▼]

We studied the contribution of the main olfactory system to mate recognition and sexual behavior in female mice. Female mice received an intranasal irrigation of either a zinc sulfate (ZnSO4) solution to destroy the main olfactory epithelium (MOE) or saline (SAL) to serve as control. ZnSO4-treated female mice were no longer able to reliably distinguish between volatile as well as nonvolatile odors from an intact versus a castrated male. Furthermore, sexual behavior in mating tests with a sexually experienced male was significantly reduced in ZnSO4-treated female mice. Vomeronasal function did not seem to be affected by ZnSO4 treatment: nasal application of male urine induced similar levels of Fos protein in the mitral and granule cells of the accessory olfactory bulb (AOB) of ZnSO4 as well as SAL-treated female mice. Likewise, soybean agglutinin staining, which stains the axons of vomeronasal neurons projecting to the glomerular layer of the AOB was similar in ZnSO4-treated female mice compared to SAL-treated female mice. By contrast, a significant reduction of Fos in the main olfactory bulb was observed in ZnSO4-treated females in comparison to SAL-treated animals, confirming a substantial destruction of the MOE. These results show that the MOE is primarily involved in the detection and processing of odors that are used to localize and identify the sex and endocrine status of conspecifics. By contrast, both the main and accessory olfactory systems contribute to female sexual receptivity in female mice. [less ▲]

Detailed reference viewed: 36 (0 ULg)
Full Text
See detailLe Règlement 44/2001 : 10 propositions de réforme
Wautelet, Patrick ULg

Conference (2006, May)

Detailed reference viewed: 34 (0 ULg)
Full Text
Peer Reviewed
See detailEvaluation of the Strepto B ID agar for the detection of group B streptococci from vaginal and recto-vaginal specimens
MELIN, Pierrette ULg; Bonafe, S.; HAYETTE, Marie-Pierre ULg et al

in ASM (Ed.) Program and Abstracts of the 106th General Meeting of the American Society for Microbiology (2006, May)

Detailed reference viewed: 25 (1 ULg)
Full Text
Peer Reviewed
See detailEnhanced urinary odor discrimination in female aromatase knockout (ArKO) mice
Wesson, D. W.; Keller, Matthieu ULg; Douhard, Quentin ULg et al

in Hormones & Behavior (2006), 49(5), 580-586

We asked whether odor discrimination abilities are sexually dimorphic in mice and, if so, whether the perinatal actions of estradiol contribute to these sex differences. The ability to discriminate ... [more ▼]

We asked whether odor discrimination abilities are sexually dimorphic in mice and, if so, whether the perinatal actions of estradiol contribute to these sex differences. The ability to discriminate different types of urinary odors was compared in male and female wild-type (WT) subjects and in mice with a hornozygous-null mutation of the estrogen synthetic enzyme, aromatase (aromatase knockout; ArKO). Olfactory discrimination was assessed in WT and ArKO male and female mice after they were gonadectomized in adulthood and subsequently treated with estradiol benzoate. A liquid olfactometer was used to assess food-motivated olfactory discrimination capacity. All animals eventually learned to distinguish between urinary odors collected from gonadally intact males and estrous females; however, WT males as well as ArKO mice of both sexes learned this discrimination significantly more rapidly than WT females. Similar group differences were obtained when mice discriminated between urinary odors collected from gonadally intact vs. castrated males or between two non-social odorants, amyl and butyl acetate. When subjects had to discriminate volatile urinary odors from ovariectomized female mice treated with estradiol sequenced with progesterone versus estradiol alone, ArKO females quickly acquired the task whereas WT males and females as well as ArKO males failed to do so. These results demonstrated a strong sex dimorphism in olfactory discrimination ability, with WT males performing better than females. Furthermore, female ArKO mice showed an enhanced ability to discriminate very similar utinary odorants, perhaps due to an increased sensitivity of the main olfactory nervous system to adult estradiol treatment as a result perinatal estrogen deprivation. (c) 2005 Elsevier Inc. All rights reserved. [less ▲]

Detailed reference viewed: 35 (0 ULg)
Full Text
Peer Reviewed
See detailPredictieve risicofactoren voor lage rugpijn bij jonge werknemers : de BELCOBACK-studie
Van Nieuwenhuyse, A.; Somville, Pierre-René ULg; Johannik, K. et al

in Tijdschrift voor bedrijfs- en verzekeringsgeneeskunde (2006), 14(4), 155-160

Detailed reference viewed: 51 (5 ULg)
Full Text
Peer Reviewed
See detailEffect Of Bovine Colostrum Supplementation On Cytokine mRNA Expression In Weaned Piglets
Boudry, Christelle ULg; Buldgen, André; Portetelle, Daniel ULg et al

in 10th International symposium on digestive physiology in pigs (2006, May)

Detailed reference viewed: 13 (2 ULg)
Full Text
Peer Reviewed
See detailThe role of rock mechanics in analyzing overbreak: application to the Soumagne tunnel
Schmitz, Robrecht Maria; Viroux, Sébastien; Charlier, Robert ULg et al

in Van Cotthem, Alain, Charlier, Robert (Ed.) EUROCK 2006 - Multiphysics Coupling and Long Term Behaviour in Rock Mechanics (2006, May)

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detailDesign of Movable Weirs and Storm Surge Barriers
Rigo, Philippe ULg; Abdelnour, R.; Bulckaen, D. et al

in PIANC 2006, 31ème Congrès de l’PIANC (Article 031) (2006, May)

Detailed reference viewed: 89 (3 ULg)
Full Text
Peer Reviewed
See detailScantling Optimization of Double-Hull Structures to Minimize their Production Cost
Richir, Thomas; Karr, D.; Rigo, Philippe ULg

in IMDC 2006, Ann Arbor, Michigan, USA, May 2006 (2006, May)

Detailed reference viewed: 49 (2 ULg)