Publications ORBi OA
Bookmark and Share    
Full Text
Peer Reviewed
See detailImportance de la mauvaise adhésion au traitement antihypertenseur
Krzesinski, Jean-Marie ULg; Krzesinski, François ULg

in Revue Médicale de Liège (2010), 65(5-6), 278-284

S’il est unanimement admis que le traitement de l’hypertension artérielle améliore le pronostic cardiovasculaire des patients qui en sont atteints, force est de constater que la moitié des patients ... [more ▼]

S’il est unanimement admis que le traitement de l’hypertension artérielle améliore le pronostic cardiovasculaire des patients qui en sont atteints, force est de constater que la moitié des patients traités n’ont pas leur pression artérielle normalisée. Un des facteurs responsables de ce relatif échec est la mauvaise adhésion au traitement (non médicamenteux et pharmacologique). Ce problème d’observance est multifactoriel. Interviennent le patient, sa maladie, son traitement et l’environnement thérapeutique où la relation médecin-malade joue un grand rôle. Pour améliorer l’observance, comme d’ailleurs la persistance du traitement, il faut d’abord y penser. Le dialogue avec le patient sur l’observance doit être mené à chaque consultation. Une excellente relation médecin-patient, une éducation sur l’hypertension, ses risques et les moyens d’éviter les complications, le choix de schémas de traitement bien tolérés, simplifiés et introduits progressivement, la recherche et la limitation des effets secondaires générés, le partenariat de la famille et du pharmacien dans la prise en charge, la stimulation de l’automesure de la pression artérielle par le patient sont autant de pistes importantes pour améliorer ce paramètre. Ceci permettrait, à coup sûr, de réduire les complications cardiovasculaires liées à l’hypertension et le coût pour la société. [less ▲]

Detailed reference viewed: 294 (19 ULg)
Full Text
See detailEcosystem services in mixed forests and monocultures: comparing stakeholders’ perceptions and scientific knowledge
Carnol, Monique ULg; Branquart, Etienne; Muys, Bart et al

in Book of Abstacts, IUFRO 7.01 Conference: Adaptation of Forest Ecosystems to Air Pollution and Climate Change, Antalya 2010 (2010)

Detailed reference viewed: 49 (7 ULg)
Full Text
Peer Reviewed
See detailL'observance thérapeutique en transplantation d'organe - L'exemple de la greffe de rein
Milicevic, Martina ULg; Grosch, Stéphanie ULg; Weekers, Laurent ULg et al

in Revue Médicale de Liège (2010), 65(5-6), 386-390

A successful transplantation implies that immunosuppressive drugs will have to be taken during the whole patient’s life. Poor drug compliance is a multifactorial problem, that is particularly dangerous in ... [more ▼]

A successful transplantation implies that immunosuppressive drugs will have to be taken during the whole patient’s life. Poor drug compliance is a multifactorial problem, that is particularly dangerous in organ transplantation as it can lead to loss of graft function and return to dialysis treatment. The medical doctor must stimulate the patient’s adherence to the strict therapeutic drug protocol. The patient must also be reminded at each medical consultation of the importance of such rigorous drug intake. This bad (or non) compliance is particularly well demonstrated a long time after transplantation. The medical staff, all the health participants, but also the family members must continuously fight against non compliance, which is inherent to any chronic disease. [less ▲]

Detailed reference viewed: 267 (5 ULg)
Full Text
Peer Reviewed
See detailPalatoschisis in the dog: developmental mechanisms and etiology
Van Den Berghe, Femke ULg; Cornillie, Pieter; Stegen, Ludo et al

in Vlaams Diergeneeskunde Tijdschift = Flemish Veterinary Journal (2010)

Detailed reference viewed: 90 (3 ULg)
Full Text
Peer Reviewed
See detailDoes plasminogen activator inhibitor-1 drive lymphangiogenesis?
Bruyere, Francoise; Melen-Lamalle, Laurence; Blacher, Silvia ULg et al

in PLoS ONE (2010), 5(3), 9653

The purpose of this study is to explore the function of plasminogen activator inhibitor-1 (PAI-1) during pathological lymphangiogenesis. PAI-1, the main physiological inhibitor of plasminogen activators ... [more ▼]

The purpose of this study is to explore the function of plasminogen activator inhibitor-1 (PAI-1) during pathological lymphangiogenesis. PAI-1, the main physiological inhibitor of plasminogen activators is involved in pathological angiogenesis at least by controlling extracellular proteolysis and by regulating endothelial cell survival and migration. Protease system's role in lymphangiogenesis is unknown yet. Thus, based on its important pro-angiogenic effect, we hypothesized that PAI-1 may regulate lymphangiogenesis associated at least with metastatic dissemination of cancer cells. To address this issue, we studied the impact of PAI-1 deficiency in various murine models of tumoral lymphangiogenesis. Wild-type PAI-1 proficient mice were used as controls. We provide for the first time evidence that PAI-1 is dispensable for tumoral lymphangiogenesis associated with breast cancers either induced by mammary carcinoma cell injection or spontaneously appearing in transgenic mice expressing the polyomavirus middle T antigen (PymT) under the control of a mouse mammary tumor virus long-terminal repeat promoter (MMTV-LTR). We also investigated inflammation-related lymphatic vessel recruitment by using two inflammatory models. PAI-1 deficiency did neither affect the development of lymphangioma nor burn-induced corneal lymphangiogenesis. These novel data suggest that vascular remodelling associated with lymphangiogenesis and angiogenesis involve different molecular determinants. PAI-1 does not appear as a potential therapeutic target to counteract pathological lymphangiogenesis. [less ▲]

Detailed reference viewed: 92 (23 ULg)
Full Text
Peer Reviewed
See detailB cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia
Kerns, H. M.; Ryu, B. Y.; Stirling, B. V. et al

in Blood (2010), 115(11), 2146-55

The immunodeficiency disorder, X-linked agammaglobulinemia (XLA), results from mutations in the gene encoding Bruton tyrosine kinase (Btk). Btk is required for pre-B cell clonal expansion and B-cell ... [more ▼]

The immunodeficiency disorder, X-linked agammaglobulinemia (XLA), results from mutations in the gene encoding Bruton tyrosine kinase (Btk). Btk is required for pre-B cell clonal expansion and B-cell antigen receptor signaling. XLA patients lack mature B cells and immunoglobulin and experience recurrent bacterial infections only partially mitigated by life-long antibody replacement therapy. In pursuit of definitive therapy for XLA, we tested ex vivo gene therapy using a lentiviral vector (LV) containing the immunoglobulin enhancer (Eµ) and IgB (B29) minimal promoter to drive B lineage-specific human Btk expression in Btk/Teck-/- mice, a strain that reproduces the features of human XLA. After transplantation of EµB29-Btk-LV-transduced stem cells, treated mice showed significant, albeit incomplete, rescue of mature B cells in the bone marrow, peripheral blood, spleen, and peritoneal cavity, and improved responses to T-independent and T-dependent antigens. LV-teated B cells exhibited enhanced B-cell antigen receptor signaling and an in vivo selective advantage in the peripheral versus central B-cell compartment. Secondary transplantation showed sustained Btk expression, viral integration, and partial functional responses, consistent with long-term stem cell marking; and serial transplantation revealed no evidence for cellular or systemic toxicity. These findings strongly support pursuit of B lineage-targeted LV gene therapy in human XLA. [less ▲]

Detailed reference viewed: 40 (1 ULg)
Full Text
See detailAssessing structure potential in soil and water conservation: monitoring top soil hydrology from micro to field scale.
Kummert, Nora ULg; Beckers, Eléonore ULg; Roisin, Christian et al

in Wollesen de Jonge, Lis; Moldrup, Per; Lindblad Vendelboe, Anders (Eds.) 1st international conference and exploratory workshop on soil architecture and physico-chemical functions "CESAR" (2010)

Soil structure is a key parameter influencing erosion and water transfers. This paper describes an experiment that covers different aspects of soil structure. Three tillage systems are tested: reduced ... [more ▼]

Soil structure is a key parameter influencing erosion and water transfers. This paper describes an experiment that covers different aspects of soil structure. Three tillage systems are tested: reduced tillage, and two ploughing systems. At micro-scale, analyses are tomography which study images to determine porosity characteristics (connectivity, size, number…) and pF curves where total available water and effective porosity are deducted. At field scale, soil losses and runoff are collected and measured after rainfall simulation on plots for the different tillage systems. The comparison of the results for both scales shows the links between phenomenons at those scales. [less ▲]

Detailed reference viewed: 72 (21 ULg)
Full Text
Peer Reviewed
See detailL’image du mois. Localisation rénale d’un lymphome
Dispas, Hélène; Delperdange, Mélanie; Meunier, Paul ULg et al

in Revue Médicale de Liège (2010), 65(7-8), 427-429

Detailed reference viewed: 62 (4 ULg)
Full Text
Peer Reviewed
See detailLa néphropathie tubulo-interstitielle aiguë: une cause rare d’insuffisance rénale aiguë
Bouquegneau, A.; Longton, J.; Bovy, Christophe ULg et al

in Revue Médicale de Liège (2010), 65(7-8), 459-463

We report the case of an acute renal failure due to an acute interstitial nephropathy (ATIN) induced by non steroidal anti-inflammatory drugs (NSAID). Even though this pathology is a rare cause of acute ... [more ▼]

We report the case of an acute renal failure due to an acute interstitial nephropathy (ATIN) induced by non steroidal anti-inflammatory drugs (NSAID). Even though this pathology is a rare cause of acute renal failure, it still requires special attention in view of the fact that it induces a high risk of acute morbidity but it also can evolve into chronic renal failure. Its differential diagnosis with other causes of acute renal failure becomes essential because of the different therapeutic care. In this article, we are going to briefly sum up the reasoning to adopt in order to diagnose an acute renal failure. [less ▲]

Detailed reference viewed: 120 (11 ULg)
Full Text
See detailFire Design of Steel Structures : Eurocode 1: Actions on structures. Part 1-2: Actions on structures exposed to fire: Eurocode 3: Design of steel structures: Part 1-2: Structural fire design
Franssen, Jean-Marc ULg; Vila Real, Paulo

Book published by Ernst & Sohn (2010)

This book explains and illustrates the rules that are given in the Eurocodes for designing steel structures subjected to fire. After the first introductory chapter, Chapter 2 explains how to calculate the ... [more ▼]

This book explains and illustrates the rules that are given in the Eurocodes for designing steel structures subjected to fire. After the first introductory chapter, Chapter 2 explains how to calculate the mechanical actions (loads) in the fire situation based on the information given in EN 1990 and EN 1991. Chapter 3 presents the models to be used to represent the thermal actions created by the fire. Chapter 4 describes the procedures to be used to calculate the temperature of the steelwork from the temperature of the compartment and Chapter 5 shows how the information given in EN 1993-1-2 is used to determine the load bearing capacity of the steel structure. The methods use to evaluate the fire resistance of bolted and welded connections are described in Chapter 7. Chapter 8 describes a computer program called ‘Elefire-EN’ which is based on the simple calculation model given in the Eurocode and allows designers to quickly and accurately calculate the performance of steel components in the fire situation. Chapter 9 looks at the issues that a designer may be faced with when assessing the fire resistance of a complete building. This is done via a case study and addresses most of the concepts presented in the earlier Chapters. Finally the annexes give basic information on the thermal and mechanical properties for both carbon steel and stainless steel. The concepts and fire engineering procedures given in the Eurocodes may seem complex to those more familiar with the prescriptive approach. This publication sets out the design process in a logical manner giving practical and helpful advice and easy to follow worked examples that will allow designers to exploit the benefits of this new approach to fire design. [less ▲]

Detailed reference viewed: 883 (8 ULg)
Full Text
Peer Reviewed
See detailIntegrating collective work aspects in the design process: An analysis case study of the robotic surgery. Using communication as a sign of fundamental change
Nyssen, Anne-Sophie ULg; Blavier, Adelaïde ULg

in Palanque, Philippe; Vanderdonck; Winckler (Eds.) Human Error, Safety and System Development (2010)

Detailed reference viewed: 65 (35 ULg)
Full Text
See detailUne chênaie n'est pas l'autre : analyse des contextes sylvicoles du chêne en forêt wallonne
Claessens, Hugues ULg; Perin, Jérôme ULg; Latte, Nicolas ULg et al

in Forêt Wallonne (2010), 108(sept-oct), 3-18

Le chêne n’est pas une essence facile à conduire vers la production de bois de qualité. Pour beaucoup d’entre eux, leur forme a été conditionnée il y a plus d’un siècle au sein de peuplements bien ... [more ▼]

Le chêne n’est pas une essence facile à conduire vers la production de bois de qualité. Pour beaucoup d’entre eux, leur forme a été conditionnée il y a plus d’un siècle au sein de peuplements bien différents de ce qu’ils sont devenus car originellement adaptés aux conditions socio-économiques qui prévalaient aux XIXe et au début du XXe siècle. Mais dans bien des cas, la sylviculture que l’on mène maintenant est encore sous la contrainte de ce passé. Cet article envisage les contextes « historico-sylvicoles » des chênaies de Wallonie à la lumière de leur état actuel. [less ▲]

Detailed reference viewed: 137 (53 ULg)
Full Text
Peer Reviewed
See detailOn a class of micromechanical damage models with initial stresses for geomaterials
Levasseur, Séverine ULg; Collin, Frédéric ULg; Charlier, Robert ULg et al

in Mechanics Research Communications (2010), 37

In this paper, we extend a class of micromechanical damage models by including initial stresses. The proposed approach is based on the solution of the Eshelby inhomogeneous inclusion problem in the ... [more ▼]

In this paper, we extend a class of micromechanical damage models by including initial stresses. The proposed approach is based on the solution of the Eshelby inhomogeneous inclusion problem in the presence of a prestress (in the matrix), adapted for elastic voided media. The closed form expression of the corresponding energy potential is used as the basis of various isotropic damage models corresponding to three standard homogenization schemes. These models are illustrated by considering isotropic tensile loadings with different initial stresses. Finally, still in the isotropic context, we provide an interpretation of the macroscopic damage model formulated by Halm-Dragon (1996) by briefly connecting it to the present study. [less ▲]

Detailed reference viewed: 44 (6 ULg)
Full Text
Peer Reviewed
See detailDisorders of consciousness: Moving from passive to resting state and active paradigms
Bruno, Marie-Aurélie ULg; Soddu, Andrea ULg; Demertzi, Athina ULg et al

in Cognitive Neuroscience (2010), 1(1), 193203

Following coma, some patients will recover wakefulness without signs of consciousness (i.e., vegetative state) or may show nonreflexive movements but with no ability for functional communication (i.e ... [more ▼]

Following coma, some patients will recover wakefulness without signs of consciousness (i.e., vegetative state) or may show nonreflexive movements but with no ability for functional communication (i.e., minimally conscious state). Currently, there remains a high rate of misdiagnosis of the vegetative state. The increasing use of fMRI and EEG tools permits the clinical characterization of these patients to be improved. We first discuss “resting metabolism” and “passive activation” paradigms, used in neuroimaging and evoked potential studies, which merely identify neural activation reflecting “automatic” processing—that is, occurring without the patient’s willful intervention. Secondly, we present an alternative approach consisting of instructing subjects to imagine well-defined sensorymotor or cognitive-mental actions. This strategy reflects volitional neural activation and, hence, witnesses awareness. Finally, we present results on blood-oxgen-level-dependent “default mode network”/resting state studies that might be a promising tool in the diagnosis of these challenging patients. [less ▲]

Detailed reference viewed: 78 (10 ULg)
Full Text
Peer Reviewed
See detailReport of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: definitions, frequency and pharmacological aspects.
Allez, Matthieu; Karmiris, Konstantinos; Louis, Edouard ULg et al

in Journal of Crohn’s and Colitis [=JCC] (2010), 4(4), 355-66

The first ECCO pathogenesis workshop focused on anti-TNF therapy failures in inflammatory bowel diseases (IBDs). The overall objective was to better understand and explore primary non response and loss of ... [more ▼]

The first ECCO pathogenesis workshop focused on anti-TNF therapy failures in inflammatory bowel diseases (IBDs). The overall objective was to better understand and explore primary non response and loss of response to anti-TNF agents in IBD. The outcome of this workshop is presented into two parts. This first section addresses definitions, frequency and pharmacological aspects of anti-TNF therapy failure, including pharmacokinetics of anti-TNF monoclonal antibodies and immune and non-immune mediated clearance of anti-TNF mAbs. The second section concerns the biological roles of TNF and TNF antagonists, including mechanisms of action of anti-TNF agents, and discuss hypothesis regarding their failures and phenomenon of paradoxical inflammation, including the potential role of TNF independent inflammatory pathways. [less ▲]

Detailed reference viewed: 39 (0 ULg)
Full Text
Peer Reviewed
See detailThe second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Definitions and diagnosis.
Van Assche, Gert; Dignass, Axel; Panes, Julian et al

in Journal of Crohn’s and Colitis [=JCC] (2010), 4(1), 7-27

Detailed reference viewed: 31 (2 ULg)
Full Text
Peer Reviewed
See detailHydro-mechanical modelling of the Excavation Damaged Zone around an underground excavation at Mont Terri Rock Laboratory
Levasseur, Séverine ULg; Charlier, Robert ULg; Frieg, Bernd et al

in International Journal of Rock Mechanics & Mining Sciences (2010), 47(3), 414-425

A zone with significant irreversible deformations and significant changes in flow and transport properties is expected to be formed in indurated clay around underground excavations. The stress ... [more ▼]

A zone with significant irreversible deformations and significant changes in flow and transport properties is expected to be formed in indurated clay around underground excavations. The stress perturbation around the excavation could lead to a significant increase of the permeability, related to diffuse and/or localized crack propagation in the material. The main objective of the study is to model these processes at large scale in order to assess their impacts on the performance of radioactive waste geological repositories. This paper concerns more particularly the hydro-mechanical modelling of a long term dilatometer experiment performed in Mont Terri Rock Laboratory in Switzerland within the Selfrac Project. The proposed model defines the permeability as a function of the aperture of the cracks that are generated during the excavation. With this model, the permeability tensor becomes anisotropic. Advantages and drawbacks of this approach are described thanks to the results of the Selfrac long term dilatometer experiment. [less ▲]

Detailed reference viewed: 214 (17 ULg)
Full Text
Peer Reviewed
See detailGenome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
Franke, Andre; McGovern, Dermot P B; Barrett, Jeffrey C et al

in Nature Genetics (2010), 42(12), 1118-25

We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in ... [more ▼]

We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 x 10). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease. [less ▲]

Detailed reference viewed: 147 (15 ULg)
Full Text
Peer Reviewed
See detailVaccinations in patients with immune-mediated inflammatory diseases.
Rahier, Jean-Francois; Moutschen, Michel ULg; Van Gompel, Alfons et al

in Rheumatology (2010), 49(10), 1815-27

Patients with immune-mediated inflammatory diseases (IMID) such as RA, IBD or psoriasis, are at increased risk of infection, partially because of the disease itself, but mostly because of treatment with ... [more ▼]

Patients with immune-mediated inflammatory diseases (IMID) such as RA, IBD or psoriasis, are at increased risk of infection, partially because of the disease itself, but mostly because of treatment with immunomodulatory or immunosuppressive drugs. In spite of their elevated risk for vaccine-preventable disease, vaccination coverage in IMID patients is surprisingly low. This review summarizes current literature data on vaccine safety and efficacy in IMID patients treated with immunosuppressive or immunomodulatory drugs and formulates best-practice recommendations on vaccination in this population. Especially in the current era of biological therapies, including TNF-blocking agents, special consideration should be given to vaccination strategies in IMID patients. Clinical evidence indicates that immunization of IMID patients does not increase clinical or laboratory parameters of disease activity. Live vaccines are contraindicated in immunocompromized individuals, but non-live vaccines can safely be given. Although the reduced quality of the immune response in patients under immunotherapy may have a negative impact on vaccination efficacy in this population, adequate humoral response to vaccination in IMID patients has been demonstrated for hepatitis B, influenza and pneumococcal vaccination. Vaccination status is best checked and updated before the start of immunomodulatory therapy: live vaccines are not contraindicated at that time and inactivated vaccines elicit an optimal immune response in immunocompetent individuals. [less ▲]

Detailed reference viewed: 48 (8 ULg)