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See detailValidation of methods for the detection of new emerging pathogenic Escherichia coli
Verstraete, K; De Reu, K; Robyn, J et al

Book published by Brussels : Belgian Science Policy (2009)

Enterohaemorrhagic Escherichia coli (EHEC) are shigatoxin producing E. coli (STEC) that can cause serious disease to humans. These food-borne pathogens belong to the fifth most common zoonoses in Belgium ... [more ▼]

Enterohaemorrhagic Escherichia coli (EHEC) are shigatoxin producing E. coli (STEC) that can cause serious disease to humans. These food-borne pathogens belong to the fifth most common zoonoses in Belgium, but due to their severe clinical symptoms in humans they are highly dreaded. They can cause a range of disease symptoms ranging from asymptomatically carriage over various diarrhoea symptoms to the life-threatening HUS (haemolytic uremic syndrome). Cattle are the main reservoir and infection of humans occurs through contact with faecal excretion material and consumption of contaminated food or water. A broad variety of serotypes is able to cause human infections, but the principal serotypes are O26, O103, O111, O145 and O157. These strains are denoted as new emerging pathogens by the WHO. The group of sorbitol non-fermenting (s-) O157:H7 strains are examined the most, because an ISO-method is available. For sorbitol fermenting (s+) O157 strains as well as for non-O157 STEC strains recently a new isolation method was developed in the Belspo project SD/AF/06A (Possé et al. 2008a). The aim of the project was the optimization and the validation of the above-mentioned detection and isolation method for STEC in different matrices. In the first place immunomagnetic separation (IMS) was evaluated for the optimization of the STEC isolation method for cattle faeces (Ghent University, UGent). Second, molecular characterization of STEC strains was performed using a newly designed 33-mPCR as an alternative tool (University of Antwerp, VIB) and pulsed field gel electrophoresis (PFGE) (Institute for Agricultural and Fisheries Research, ILVO). Also a smaller derived multiplex PCR (9-mPCR) was designed (VIB) and optimized for the screening of samples (ILVO). The third goal was the evaluation of different approaches for STEC isolation from human faecal samples (Universitair Ziekenhuis Brussel, UZ). Finally the STEC detection and isolation method was validated by an in-house and an interlaboratory study which was based on the ISO 16140 guideline for the validation of alternative methods (University of Liège; UGent; ILVO). For the optimization of the STEC isolation protocol for cattle faeces and the evaluation of the effect of IMS, cattle faecal samples were artificially inoculated with various numbers of STEC (10-100 and 100-1000 cfu/25g faeces) and isolated using the isolation protocol with 6h or 24h of enrichment followed by IMS and plating or direct plating on selective agars. Two types of IMS beads (Dynabeads and Captivate beads) were tested. Results showed that IMS (any of the two types of beads) had a highly positive effect on the isolation of serotype O157 (s- and s+), whereas only a small or even a negative effect for non-O157 serotypes was found. This was largely clarified by results on pure broth suspensions of STEC, showing that high percentages were recovered from the IMS beads used in suspensions with the serotypes O157 (s- and s+), O26 and O103, but lower percentages were recovered for O111 and O145. Non-O157 STEC were often already efficiently isolated from faeces using only direct plating, whereas O157 (s- and s+) STEC were not. For the enrichment time, 24h generally gave higher isolation efficiencies than 6h. Finally for serotypes O157 (s- and s+), O26 and O103, a level of 10-100 cfu/25g was reliably detected, whereas for serotypes O111 and O145 only 100-1000 cfu/25g was reliably detected. To accomplish the second task of the project, the Applied Molecular Genomics Group of the VIB Department of Molecular Genetics (UA-VIB) designed a proprietary 33-amplicon multiplex PCR (mPCR) assay combined with capillary electrophoresis. This mPCR assay contains the detection of 5 STEC serotypes (O26, O103, O111, O145, O157), the main virulence genes VT1 with variants (VT1ab, VT1c and VT1d), VT2 with six variants (VT2b,c,d,e,f,g) and consensus, eae with five variants (eaeα1, eaeβ1, eaeγ1; eaeγ2; eaeε and eaeζ), ehx, tir, katP, saa, espP and FliC H2, H7, H8, H11 and H28. The assay was optimized and validated on a set of test strains representative for the priority amplicons. Next, this molecular technology was validated on a collection of 334 human clinical and animal strains from the Belgian STEC Reference Center (UZ). This collection of human and animal strains was also characterized by performing the PulseNet Europe protocol for pulsed field gel electrophoresis (PFGE). This technique creates a fingerprint of a strain by means of rare cutter restriction enzyme cutting of DNA and gel electrophoresis. Analysis of the band patterns lead to clustering of strains according to similarity or relatedness. Then results of 33-mPCR and PFGE genotyping were combined to show eventual correlations between PFGE genotypes and virulence profiles. Also background information about the strains (date of isolation, human or animal source, clinical manifestation, outbreak information) was included to the analysis. Combining mPCR and PFGE genotyping results, correlations were shown. In the first place STEC strains were clustered according to their serotype. Secondly a correlation occurred between virulence profile and PFGE clustering, concerning VT genes and other genes. Particularly for STEC O157, strains had very diverse VT-profiles, and strains with the same VT-profile clustered together. Concerning the clinical manifestation, ‘asymptomatic’ cases occurred more frequently for non-O157 than for O157 STEC, but besides this no correlation was shown between the PFGE clustering and the clinical manifestation or between the VT-profile and the clinical manifestation. Finally several case studies could be appointed based on the PFGE dendrograms. In general the cases contained clones that persisted during several years, had similar virulence profiles and infected humans as well as animals. As a part of the second task, the UA-VIB also designed a derived 9-amplicon multiplex PCR (9-mPCR) for fast sample screening. Using this 9-mPCR, a combination of serotypes (O26, O103, O111, O145, O157) and virulence genes (VT1, VT2, eae and ehx) is detected in one run and can be visualized using conventional gel electrophoresis. Once the 9-mPCR was developed and tested on pure strains, an evaluation on samples was performed. Hereto ILVO (Institute for Agricultural and Fisheries Research) tested several methods to extract DNA from artificially inoculated samples. Methods were compared based on the ability to remove PCR inhibiting molecules and on the ability to isolate and purify DNA from STEC cells. Out of four methods only two methods, in which no removal of sample debris was done, were suitable for sample preparation. The method using bead beating cell lysis described by Yu and Morrison (2004), was at least 10 times more sensitive than the method using the Qiagen Stool Mini Kit according to the manufacturer’s instructions, and was therefore recommended. However, the method using bead beating cell lysis is much more time consuming than the Qiagen method and the use of a ribolyser is necessary. As ILVO used the method employing the ribolyser in all following experiments, this method was used on artificially inoculated samples to determine its detection limit. All virulence marker genes and the serotype gene of strain MB3901 (serotype O157) could be detected in enriched minced beef and cheese from raw milk artificially inoculated with 2 cfu/25g sample. For cattle fecal samples the screening test was 10 times less sensitive; 21 cfu/25g feces could be detected. Finally the influence of the volume of lysate used in the mPCR reaction mix was examined. An mPCR reaction containing 1 and 2µl of lysate DNA was performed, but no difference in detection was seen. Testing of different clinical isolates of non-O157 STEC on the newly designed selective agars, showed that growth characteristics were generally as expected. However, more standardization of the preparation of the medium is needed to obtain more reproducible results. Some O103 isolates did not grow on the media prepared at UZ and the color of the colonies of O111 was often difficult to distinguish from O26. Using artificially contaminated stool samples, the sensitivity of the STEC isolation protocol developed in a previous Belspo SPSD II project was similar to the protocol used routinely at UZ (103 and 104 cfu/5g). The sensitivity was about 10 times higher when using IMS. The method performed well on frozen STEC positive samples, but this could only be tested on 14 samples, of which 11 with O157, 2 with O111 and one O26. In-house validation of the STEC isolation protocol was performed to evaluate if the protocol is applicable for different types of food matrices. All samples used for this validation were artificially contaminated. Ten samples of minced beef, raw milk cheese and sprouted seeds were artificially inoculated with varying numbers (10-2000 cfu/25g) of non-stressed and stressed strains belonging to the serotypes O157 (s-) and (s+), O26, O103, O111 and O145. Cultured STEC strains were cold and freeze stressed by storing them for at least 5 days at respectively 2 and -18°C. Inoculated samples were pre-enriched in a weak selective medium for 6 hours followed by enrichment in a stronger selective medium for 18 hours. Direct plating on a selective medium was performed after each enrichment step. In a third pathway, an IMS (Dynabeads or Captivate beads) step was performed after 24h enrichment and prior to plating. Suspected colonies on the selective medium were purified and tentatively confirmed on a purification medium followed by a confirmation by a serotype PCR. Parallel to the classical isolation method, the 9-mPCR screening test was performed on the enrichment medium (after 24 hours enrichment). Results indicate that the isolation protocol as well as mPCR screening provide good detection of non-stressed and cold-stressed O26, O103, O157 (s+) and O145 in raw milk cheese and minced beef. Detection of the other non-stressed and cold-stressed serotypes (O111 and O157 (s+)) in raw milk cheese and minced beef and of all serotypes under freeze stressed conditions in minced beef was low or almost zero. Probably due to the high level of background flora, detection of any serotype in sprouted seeds was almost impossible even though inoculation numbers were as high as 2000 cfu/25g. Finally the optimized STEC detection and isolation methods were validated by an interlaboratory study performed by national and international laboratories (twelve laboratories in total). First, a pre-trial experiment was organized to give the collaborative laboratories the possibility to become familiar with the isolation method. Secondly, the actual interlaboratory study was performed. Products necessary to prepare all culture media (in-house-prepared: IHP) and ready-to-use selective agar culture media (ready-to-use: RTU) were sent to the participating laboratories, as well as a questionnaire and a document to report the results. For each participating laboratory, 20 samples of 25g of minced beef were prepared: one sample for the temperature measurement upon arrival, one for the enumeration of the total count, Enterobacteriaceae and E. coli, two blank samples and sixteen samples inoculated with single strains belonging to 4 serotypes at 2 levels of contamination in duplicate (30 cfu/g and 300 cfu/g). All strains were cold stressed. Samples were prepared the day of the shipment and had to be analyzed on a prefixed day. The University of Liège evaluated all results based on the recommendations of ISO 16140. Results showed no difference between RTU and IHP media. The arabinose test seemed difficult to be read, so the dulcitol test is now preferred for the confirmation of serotypes O103 and O111. Some mistakes were made during sample inoculation, like a wrong inoculation of four samples and no inoculation of one sample. If we do not take into account these mistakes, all four serotypes were detected with high sensitivity. In general it can be concluded that the laboratory performance is highly satisfactory. [less ▲]

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See detailLes cardiomyopathies dans l’espèce bovine
Brihoum, Mounir ULg; Rollin, Frédéric ULg; Amory, Hélène ULg

in Annales de Médecine Vétérinaire (2009), 153(3), 156-163

Cardiomyopathies in cattle are disorders that are sometimes encountered by rural practitioner. They usually lead to cardiac dysfunction, heart failure, arrhythmias and even sudden death. Most of ... [more ▼]

Cardiomyopathies in cattle are disorders that are sometimes encountered by rural practitioner. They usually lead to cardiac dysfunction, heart failure, arrhythmias and even sudden death. Most of cardiomyopathies in cattle are of hereditary, nutritional or toxic origin. Bovine cardiomyopathies may involve only one animal as they may affect several animals of the farm and can cause considerable economic losses either in treatment costs, decrease of zootechnical performances or in mortality. The etiological variability of cardiomyopathies as well as non-specificity of clinical signs often complicate the diagnostic approach of the practitioner. In this paper, a literature review on cardiomyopathies that may occur in cattle is proposed. Their different aetiologies and clinical aspects as well as diagnostic means in affected cattle are discussed [less ▲]

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See detailUniformisation des critères de publication et émergence de "nouveaux" discours dans le domaine des sciences de la gestion
Robert, Jocelyne ULg

in Defays, Jean-Marc; Englebert, Annick; al. (Eds.) "Principes et typologie des discours universitaires" Tome 1 (2009)

À partir des changements que connaît le monde des sciences de la gestion, nous avons analysé l’uniformisation des critères de publication d’une part, le développement de « nouveaux » discours d’autre part ... [more ▼]

À partir des changements que connaît le monde des sciences de la gestion, nous avons analysé l’uniformisation des critères de publication d’une part, le développement de « nouveaux » discours d’autre part. Ces éléments ne sont pas indépendants d’une situation globale de concurrence, de recherche d’excellence et de rentabilité. Ils contribuent à redéfinir les valeurs, les règles et les normes de fonctionnement du champ scientifique, les signes de reconnaissance, les positions des acteurs et leur mode de relations. Nous avons souhaité montrer les influences extérieures et les forces internes qui contribuent à expliquer cette situation. [less ▲]

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See detailMultidimensional generalized automatic sequences and shape-symmetric morphic words
Charlier, Emilie ULg; Kärki, Tomi; Rigo, Michel ULg

in Proceedings of AutoMathA (2009)

An infinite word is S-automatic if, for all n ≥ 0, its (n + 1)st letter is the output of a deterministic automaton fed with the representation of n in the considered numeration system S. In this paper, we ... [more ▼]

An infinite word is S-automatic if, for all n ≥ 0, its (n + 1)st letter is the output of a deterministic automaton fed with the representation of n in the considered numeration system S. In this paper, we consider an analogous definition in a multidimensional setting and study the relationship with the shape-symmetric infinite words as introduced by Arnaud Maes. Precisely, for d ≥ 2, we show that a multidimensional infinite word x : N^d → Σ over a finite alphabet Σ is S-automatic for some abstract numeration system S built on a regular language containing the empty word if and only if x is the image by a coding of a shape-symmetric infinite word. [less ▲]

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See detailQuelques points de repère à la pratique de la clinique carcérale
Englebert, Jérôme ULg

in psychologos (2009)

Alors que la psychanalyse se révèle comme un référent théorique fréquemment utilisé en clinique carcérale, il semble opportun d’interroger quelques-uns des principes fondateurs de la théorie freudienne ... [more ▼]

Alors que la psychanalyse se révèle comme un référent théorique fréquemment utilisé en clinique carcérale, il semble opportun d’interroger quelques-uns des principes fondateurs de la théorie freudienne. Le dispositif spatial et le cadre temporel spécifiques posent plusieurs problèmes majeurs à la pratique de la psychologie clinique. Ces simples constats ne sont pas sans entraîner d’importantes répercussions théoriques et, notamment, celle de l’émergence de la problématique du corps. Un corps qui n’est plus le corps libidinal de la psychanalyse mais une réalité ontologique à étudier sous l’angle phénoménologique. In fine, c’est l’acte – le corps en mouvement – qui s’impose comme paradigme de la rencontre avec le détenu. [less ▲]

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See detailA study of the high temperature spin reorientation in YCoFe/sub 3/B
Grandjean, Fernande ULg; Sougrati, Moulay Tahar ULg; Mayot, H. et al

in Journal of Physics : Condensed Matter (2009), 21(18), 1860017-1860017

The iron-57 Mossbauer spectra of YCoFe /sub 3/ B have been measured between 4.2 and 480 K and reveal that YCoFe /sub 3/ B exhibits an axial orientation of the iron magnetic moments below 450 K and a basal ... [more ▼]

The iron-57 Mossbauer spectra of YCoFe /sub 3/ B have been measured between 4.2 and 480 K and reveal that YCoFe /sub 3/ B exhibits an axial orientation of the iron magnetic moments below 450 K and a basal orientation above 450 K. This spin reorientation, also observed in the thermomagnetic curves, results from the different signs of the contributions to the magnetic anisotropy of the 2c and 6i sites that are occupied by iron. The neutron diffraction patterns of YCoFe /sub 3/ B have been measured at 2 K and between 290 and 770 K and have been successfully analyzed with a model compatible with the magnetic orientation obtained from the Mossbauer spectra. The hybridization between the cobalt or iron 3d orbitals and the boron 2p orbitals leads to a larger magnetic moment and hyperfine field on the 2c site as compared to the 6i site. [less ▲]

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See detailInferring bounds on the performance of a control policy from a sample of one-step system transitions
Fonteneau, Raphaël ULg; Murphy, Susan A.; Wehenkel, Louis ULg et al

in 28th Benelux Meeting on Systems and Control (2009)

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See detailThe DynaMICCS perspective. A mission for a complete and continuous view of the Sun dedicated to magnetism, space weather and space climate
Turck-Chièze, S.; Lamy, P.; Carr, C. et al

in Experimental Astronomy (2009), 23

The DynaMICCS mission is designed to probe and understand the dynamics of crucial regions of the Sun that determine solar variability, including the previously unexplored inner core, the radiative ... [more ▼]

The DynaMICCS mission is designed to probe and understand the dynamics of crucial regions of the Sun that determine solar variability, including the previously unexplored inner core, the radiative/convective zone interface layers, the photosphere/chromosphere layers and the low corona. The mission delivers data and knowledge that no other known mission provides for understanding space weather and space climate and for advancing stellar physics (internal dynamics) and fundamental physics (neutrino properties, atomic physics, gravitational moments...). The science objectives are achieved using Doppler and magnetic measurements of the solar surface, helioseismic and coronographic measurements, solar irradiance at different wavelengths and in-situ measurements of plasma/energetic particles/magnetic fields. The DynaMICCS payload uses an original concept studied by Thalès Alenia Space in the framework of the CNES call for formation flying missions: an external occultation of the solar light is obtained by putting an occulter spacecraft 150 m (or more) in front of a second spacecraft. The occulter spacecraft, a LEO platform of the mini sat class, e.g. PROTEUS, type carries the helioseismic and irradiance instruments and the formation flying technologies. The latter spacecraft of the same type carries a visible and infrared coronagraph for a unique observation of the solar corona and instrumentation for the study of the solar wind and imagers. This mission must guarantee long (one 11-year solar cycle) and continuous observations (duty cycle > 94%) of signals that can be very weak (the gravity mode detection supposes the measurement of velocity smaller than 1 mm/s). This assumes no interruption in observation and very stable thermal conditions. The preferred orbit therefore is the L1 orbit, which fits these requirements very well and is also an attractive environment for the spacecraft due to its low radiation and low perturbation (solar pressure) environment. This mission is secured by instrumental R and D activities during the present and coming years. Some prototypes of different instruments are already built (GOLFNG, SDM) and the performances will be checked before launch on the ground or in space through planned missions of CNES and PROBA ESA missions (PICARD, LYRA, maybe ASPIICS). [less ▲]

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See detailGender and attachment representations in the preschool years: Comparisons between five countries.
Pierrehumbert, Blaise; Roskam, Isabelle; Stievenart, Marie ULg

in Journal of Cross-Cultural Psychology (2009), 40(4),

Bowlby proposed that the individual’s social experiences, as early as in infancy, contribute to the construction of Internal Working Models (IWMs) of attachment, which will later guide the individual’s ... [more ▼]

Bowlby proposed that the individual’s social experiences, as early as in infancy, contribute to the construction of Internal Working Models (IWMs) of attachment, which will later guide the individual’s expectations and behaviors in close relationships all along his or her life. The qualitative, individual characteristics of these models reflect the specificity of the individual’s early experiences with attachment figures. The attachment literature globally shows that the qualities of IWMs are neither gender specific nor cultural specific. Procedures to evaluate IWMs in adulthood have been well established, based on narrative accounts of childhood experiences. Narrative procedures at earlier ages (e.g., in the preschool years) have been proposed, such as Bretherton’s Attachment Story Completion Task (ASCT), to evaluate attachment representations. More than 500 ASCT narratives of preschoolers, coming from five different countries, have been collected, in the perspective of examining possible interactions between gender and culture regarding attachment representations. A specific Q-Sort coding procedure (CCH) has been used to evaluate several dimensions of the narratives. Girls’ narratives appeared as systematically more secure than those of same-age boys, whatever their culture. The magnitude of gender differences, however, varied between countries. Taylor’s model of gender-specific responses to stress and Harwood’s and Posada’s hypothesis on intercultural differences regarding caregiving are evoked to understand the differences across gender and countries. [less ▲]

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See detailACLALS @ Buckingham Palace: A Cynical Scholar's Report on the Celebration of the Commonwealth's Diamond Anniversary
Tunca, Daria ULg

in Davis, Geoffrey V.; Delrez, Marc; Ledent, Bénédicte (Eds.) ACLALS Newsletter (2009)

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See detailDesign Procedure of a Nonlinear Vibration Absorber Using Bifurcation Analysis
Viguié, Régis ULg; Kerschen, Gaëtan ULg

in 27th International Modal Analysis Conference, Orlando, 2009 (2009)

A nonlinear energy sink (NES) is characterized by its ability to passively realize targeted energy transfer as well as multimodal damping. This latter feature seems to make this device very well suited ... [more ▼]

A nonlinear energy sink (NES) is characterized by its ability to passively realize targeted energy transfer as well as multimodal damping. This latter feature seems to make this device very well suited for reducing the vibration level of MDOF linear structures. The perspective of dealing with MDOF linear primary structures requires the development of an efficient NES design procedure. This paper poses the basis of such a procedure based upon the bifurcation analysis of a system composed of a linear oscillator coupled to a NES, using the software MatCont. [less ▲]

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See detailChallenges for Biomarker Discovery in Body Fluids Using SELDI-TOF-MS
De Bock, Muriel ULg; De Seny, Dominique ULg; Meuwis, Marie-Alice ULg et al

in Journal of Biomedicine & Biotechnology (2009)

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See detailEtudier à l'université : le poids des pairs et du capital culturel face aux aspirations d'étude.
Dupriez, Vincent; Monseur, Christian ULg; Van Campenhoudt, Maud

in Cahiers de Recherche en Éducation et Formation (2009), 75

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See detailOptimisation des calendriers d'irrigation pour le périmètre irrigué de la Vallée du Kou à l'aide du logiciel SIMIS
Wellens, Joost ULg; Nitcheu, Martial; Sawadogo, Brehima et al

in Journées Scientifiques 2iE; 2009 (2009)

La vallée du Kou, situé dans le Sud-ouest du Burkina Faso, a été depuis le milieu des années 70, le lieu d’un développement rapide de l’irrigation. Reconnue comme une excellente plaine à vocation agricole ... [more ▼]

La vallée du Kou, situé dans le Sud-ouest du Burkina Faso, a été depuis le milieu des années 70, le lieu d’un développement rapide de l’irrigation. Reconnue comme une excellente plaine à vocation agricole, notamment pour la riziculture en raison de ses potentialités hydrauliques, le périmètre irrigué de la vallée du Kou revêt une importance majeure dans les économies à proximité. Malheureusement, ce périmètre de 1.260 ha est aujourd’hui peu performant. Les causes principales sont les pénuries en eau chroniques dues à une intensification des utilisateurs en amont du périmètre et la mauvaise gestion de l’eau sur le périmètre. C’est dans ce sens qu’il a été jugé nécessaire d’entreprendre une stratégie d’amélioration de la gestion de l’irrigation sur le périmètre. Après avoir élaboré un diagnostic des efficiences en irrigation, le logiciel SIMIS (Mateos et al., 2002) a été mis en place afin de proposer des scénarii d’irrigation fiables et équitables. [less ▲]

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See detailLe périmètre irrigué de la Vallée du Kou: Diagnostic des efficiences hydro-agricole et élaboration des calendriers d'irrigation à l'aide de SIMIS (étude de cas)
Wellens, Joost ULg; Nitcheu, Martial

Report (2009)

La vallée du Kou a été depuis le milieu des années 70, le lieu d’un développement rapide de l’irrigation. Reconnue comme une excellente plaine à vocation agricole notamment pour la riziculture, en raison ... [more ▼]

La vallée du Kou a été depuis le milieu des années 70, le lieu d’un développement rapide de l’irrigation. Reconnue comme une excellente plaine à vocation agricole notamment pour la riziculture, en raison de ses importantes potentialités hydrauliques le périmètre irrigué de la vallée du Kou revêt une importance majeure dans les économies des communautés rurales et urbaines situées à proximité. D’une superficie totale aménagée de 1.260 ha, l’aménagement dudit périmètre à vocation rizicole a été réalisé de 1969 à 1970 dans le cadre de l’autosuffisance alimentaire. Malheureusement, ce périmètre est aujourd’hui peu performant à cause de la réduction progressive des surfaces emblavées au fil des années et de la faible productivité. De 7 t/ha environ de paddy par campagne pendant les premières années après l’aménagement, les rendements sont passés à 4 t/ha dans les dernières années. Actuellement, en station d’essai, les rendements atteignent 7 à 8 t/ha. Cela montre donc clairement les possibilités d’accroître les rendements sur les périmètres irrigués. Les causes principales de cette contre performance sont des pénuries en eau chroniques due à une intensification des utilisateurs en amont du périmètre et la mauvaise gestion de l’eau sur le périmètre. La question de la gestion de l’eau d’irrigation devient alors primordiale. C’est dans ce sens qu’il a été jugé nécessaire d'entreprendre une stratégie d'amélioration de la gestion de l'irrigation sur le périmètre. Après avoir élaboré un diagnostic des efficiences en irrigation, le logiciel SIMIS a été mis en place afin de proposer des scénarii d’irrigation fiables et équitables. [less ▲]

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See detailDroit et philosophie du langage ordinaire
Pieret, Denis ULg

in Dissensus (2009), 3

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See detailAnthropologie et migrations africaines : une généalogie des recherches
Kuczynski; Razy, Elodie ULg

in Revue Européenne des Migrations Internationales (2009), 25(3), 79-100

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See detailInsuline detemir (Levemir) dans l'etude predictive: resultats obtenus chez les patients diabetiques de type 1 de la cohorte belge.
Philips, Jean-Christophe ULg; Scheen, André ULg

in Revue Médicale de Liège (2009), 64(3), 124-30

Insulin detemir (Levemir) is a soluble human insulin analogue acylated with a 14-carbon fatty acid, which reversibly binds to albumin, thereby providing a more prolonged metabolic effect with lower ... [more ▼]

Insulin detemir (Levemir) is a soluble human insulin analogue acylated with a 14-carbon fatty acid, which reversibly binds to albumin, thereby providing a more prolonged metabolic effect with lower variability as compared to NPH insulin taken as reference. Thanks to this pharmacokinetic and pharmacodynamic profile, insulin detemir is essentially used within a basal-bolus regimen. We report the results obtained in 232 type 1 diabetic patients recruited in Belgium in the frame of the international observational, open, prospective PREDICTIVE study. In patients initially treated with either NPH insulin or glargine, followed for 26 weeks, the shift to insulin detemir did not change HbA1c levels, but significantly reduced both the mean and the variability of fasting blood glucose levels while diminishing the risk of hypoglycaemic episodes, especially at night. Therefore, insulin detemir was associated with significantly improved quality of life. These changes were obtained with a slight increase in daily insulin doses but without weight gain. [less ▲]

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