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See detailThe stem cell mobilizing capacity of patients with acute myeloid leukemia in complete remission correlates with relapse risk: results of the EORTC-GIMEMA AML-10 trial
Keating, S.; Suciu, S.; de Witte, T. et al

in Leukemia (2003), 17(1), 60-67

Variable numbers of CD34(+) cells can be harvested from the blood of AML patients in CR after G-CSF supported mobilization following consolidation chemotherapy. We hypothesized that a decreased ability to ... [more ▼]

Variable numbers of CD34(+) cells can be harvested from the blood of AML patients in CR after G-CSF supported mobilization following consolidation chemotherapy. We hypothesized that a decreased ability to mobilize stem cells reflects a chemotherapy-induced reduction in the number of normal and leukemic stem cells. We therefore analyzed whether the mobilizing capacity of these patients was of prognostic significance. 342 AML-patients in first CR received daily G-CSF from day 20 of the consolidation course and underwent 1-6 aphereses to obtain a minimum dose of 2 x 10(6) CD34(+) cells/kg. Afterwards they were randomized for autologous bone marrow (M) or blood SCT. As a surrogate marker for the mobilizing capacity, the highest yield of CD34(+) cells of a single apheresis was adopted. Patients could be categorized into four groups: no harvest (n = 76), low yield (<1 x 10(6) CD34(+)/kg; n = 50), intermediate yield (1-6.9 x 10(6) CD34(+) cells/kg; n = 128) and high yield ( :7 x 106 CD34+ cells/kg; n = 88). The median follow-up was 3.4 years; 163 relapses and 16 deaths in CR were reported. Autologous blood or BM SCT was performed in 36%, 64%, 81% and 88%, respectively, of the patients assigned to the no harvest, low, intermediate and high CD34(+) yield group. The 3-year disease-free survival rate was 46.7%, 65.0%, 50.4% and 26.9% (P= 0.0002) and the relapse incidence was 47.5%, 30.1%, 43.1% and 71.9% (P < 0.0001). Multivariate Cox's proportional hazards model showed that the CD34(+) yield was the most important independent prognostic variable (P = 0.005) after cytogenetics. Patients with the highest mobilizing capacity have a poor prognosis due to an increased relapse incidence. [less ▲]

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See detailPhenomenal characteristics of cryptomnesia
Brédart, Serge ULg; Lampinen, J. M.; Defeldre, A. C.

in Memory (2003), 11(1), 1-11

Qualitative characteristics of cryptomnesia, or unintentional plagiarism were investigated. In Experiment I we compared accurate and inaccurate source attributions in terms of their level of confidence ... [more ▼]

Qualitative characteristics of cryptomnesia, or unintentional plagiarism were investigated. In Experiment I we compared accurate and inaccurate source attributions in terms of their level of confidence using instructions that did not require a fixed number of responses. Confidence was lower for plagiarised responses than for correct responses. Nevertheless, participants provided high ratings of certainty for a large proportion of their plagiarised responses. In Experiment 2 the phenomenological differences between plagiarised recall and veridical recall were compared by using an adaptation of the memory characteristics questionnaire (Johnson, Foley, Suengas, [less ▲]

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See detailSafe treatment of thiopurine S-methyltransferase deficient Crohn's disease patients with azathioprine
Kaskas, B. A.; Louis, Edouard ULg; Hindorf, U. et al

in Gut (2003), 52(1), 140-142

Thiopurine S-methyltransferase (TPMT) deficient patients develop life threatening haematoxicity (for example, pancytopenia) when treated with a standard dose of azathioprine (AZA) and 6-mercaptopurine (6 ... [more ▼]

Thiopurine S-methyltransferase (TPMT) deficient patients develop life threatening haematoxicity (for example, pancytopenia) when treated with a standard dose of azathioprine (AZA) and 6-mercaptopurine (6-MP) due to excessive accumulation of cytotoxic metabolites. At present, it is generally recommended that these patients should not receive AZA or 6-MP treatment for inflammatory bowel disease. We report for the first time that Crohn's disease patients with TPMT deficiency can be successfully treated with AZA. We illustrate this with three cases where treatment has been successful and toxicity has been avoided by carefully titrating the drug dose. Thus very low TPMT activity demands pharmacogenetically guided dosing. [less ▲]

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See detailLa détention et l'expulsion collective des étrangers. Commentaire de l'affaire Conka
Carlier, Jean-Yves ULg

in Revue Trimestrielle des Droits de l'Homme [= RTDH] (2003), 14(53), 198-222

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See detailUtilisation des pesticides dans le contexte de la production de fruits et légumes exportés
Schiffers, Bruno ULg

Scientific conference (2003, January)

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See detailANGULAR DEPENDENT VORTEX DYNAMICS IN SUPERCONDUCTORS WITH COLUMNAR DEFECTS
Civale, L.; Silhanek, Alejandro ULg; Pasquini, G.

in Narlikar, Anant (Ed.) Irradiation effects and cationinc disorder in HTS (2003)

This book chapter described the vortex pinning properties of type II superconductors with columnar defects by means of magnetization and ac-susceptibility measurements.

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See detailPROTECCIÓN JURÍDICA DEL PATRIMONIO CULTURAL COLOMBIANO. EL PLURALISMO PRINCIPIO ORIENTADOR DE UNA CULTURA DE PAZ
Marquez Guerra, José Francisco ULg

Master's dissertation (2003)

Este trabajo intenta desde una de las múltiples formas posibles abordar el estudio del patrimonio cultural. El primero de sus propósitos es presentar un análisis jurídico sobre el desarrollo evolutivo del ... [more ▼]

Este trabajo intenta desde una de las múltiples formas posibles abordar el estudio del patrimonio cultural. El primero de sus propósitos es presentar un análisis jurídico sobre el desarrollo evolutivo del concepto, su significado, los bienes y valores que comprende y su funcionalidad como crisol de identidades, dentro del marco normativo de la jurisdicción colombiana y el correspondiente régimen que somete el acervo cultural de la nación. El segundo propósito es plantear el pluralismo como principio fundamental que orienta y describe la acción del Estado Social de Derecho hacia el reconocimiento efectivo de las diversidades que conforman el pueblo colombiano. Se intenta demostrar, que la integración nacional sólo se logra cimentando la identidad cultural sobre el diálogo intercultural y la disposición abierta a la interacción con otras culturas dentro y más allá del ámbito Estatal. [less ▲]

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See detailLe cas clinique du mois. Masse médiastinale antérieure chez une patiente acromégale.
Laret, Vinciane ULg; Valdes Socin, Hernan Gonzalo ULg; Betea, Daniela ULg et al

in Revue Médicale de Liège (2003), 58(12), 724-728

The discovery of an anterior asymptomatic mediastinal mass with acromegaly creates a dilemma for the clinician. As acromegaly can be due to a pituitary tumor but also to an ectopic production of GHRH, the ... [more ▼]

The discovery of an anterior asymptomatic mediastinal mass with acromegaly creates a dilemma for the clinician. As acromegaly can be due to a pituitary tumor but also to an ectopic production of GHRH, the first diagnostic step consists of finding the etiology of the disease in order to use adequate treatment. This can be complicated by the fact that acromegaly can be associated with other tumors (for instance in MEN-1 disease and Carney Complex) and because chronic GH hypersecretion can stimulate tumor overgrowth and perhaps tumor formation. We describe the case of a 44-year-old acromegalic woman with an anterior mediastinal mass. We present the different diagnoses and a review of the literature. [less ▲]

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See detailVivre la démarche expérimentale, de la Haute Ecole vers l'école primaire
Hindryckx, Marie-Noëlle ULg; Brouwir, Christine ULg; Graftiau, Marie-Christine et al

Conference (2003)

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See detailNumerical mdeling of hydro-mechanical fracture behaviour
Guiducci, Chiara; Collin, Frédéric ULg; Radu, Jean-Pol ULg et al

Conference (2003)

A numerical approach for modeling coupled Hydro-Mechanical fracture behavior in 2D is presented in this paper. This approach accounts for the strong dependence of the flow characteristics on fracture ... [more ▼]

A numerical approach for modeling coupled Hydro-Mechanical fracture behavior in 2D is presented in this paper. This approach accounts for the strong dependence of the flow characteristics on fracture apertures and offers an anisotropic description of the flow propagation in the fracture. An interface finite element and a constitutive model are developed . In order to validate the applicability of the model to general geomechanic problems, 2D simulations were performed. Results show the good application of the mathematical model and the fundamental hydraulic role played by the fractures. [less ▲]

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See detailLe pas du temps. Ou l’incorporation du social
Durand, Pascal ULg

in Dumortier, Jean-Louis (Ed.) Le Roman de Simenon. Pedigree : entre réalité et fiction (2003)

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See detailThe use of the Tosoh AIA-600II and AIA-1800 immunoassay analysers for the determination of CTNI
Chapelle, Jean-Paul ULg; Aldenhoff, Marie-Claire ULg; Gielen, Jacques

in Clinical Chemistry & Laboratory Medicine (2003), 41

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See detailLe cancer medullaire de la thyroide ou, comment des marqueurs tumoraux et les outils de la genetique autorisent le deploiement de mesures preventives.
Meurisse, Nicolas ULg; Defechereux, Thierry ULg; Hamoir, Etienne ULg et al

in Revue Médicale de Liège (2003), 58(5), 346-350

Medullary thyroid cancer (MTC) arises from parafollicular C cells secreting calcitonin. MTC occurs both as sporadic tumors and as part of specific inherited autosomal dominant syndromes in which point ... [more ▼]

Medullary thyroid cancer (MTC) arises from parafollicular C cells secreting calcitonin. MTC occurs both as sporadic tumors and as part of specific inherited autosomal dominant syndromes in which point mutations within a discrete set of RET codons were described. Total thyroidectomy and aggressive neck dissection represents the only chance for cure in the affected patients. Therefore, all patients with thyroid nodular disease should undergo measurement of calcitonin plasma levels to allow preclinical diagnosis of the disease and early appropriate surgery ("secondary prevention"). In case of proband patient for inherited disease, all the family members should be genetically screened to detect the disease gene carriers. Patients with germline mutation would benefit either from earlier surgery at the stage of C-cell hyperplasia or microcarcinoma or prophylactic surgery (total thyroidectomy without neck dissection) (primary prevention) before the onset of any C-cells pathology. The ideal age for performance of such prophylactic surgery is determined by the genotypic features of the disease. [less ▲]

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See detailThe changing spectrum of TSH-secreting pituitary adenomas: diagnosis and management in 43 patients.
Valdes Socin, Hernan Gonzalo ULg; Chanson, Philippe; Delemer, B. et al

in European Journal of Endocrinology (2003), 148(4), 433-442

OBJECTIVE: Our aim was to report the recent changes in diagnosis and management of TSH-secreting pituitary adenomas. METHODS: We retrieved 43 consecutive patients with TSH-secreting pituitary tumors (23 ... [more ▼]

OBJECTIVE: Our aim was to report the recent changes in diagnosis and management of TSH-secreting pituitary adenomas. METHODS: We retrieved 43 consecutive patients with TSH-secreting pituitary tumors (23 male and 20 female) among 4400 pituitary adenomas followed between 1976 and 2001 in six Belgian and French centers. RESULTS: TSH was elevated in 18/43 and alpha subunit in 13/32 patients. In patients with intact thyroid (n=30), mean free tri-iodothyronine was 13.1 pmol/l (range 3.5-23) and mean free thyroxine was 38.4 pmol/l (range 10.2-62.7). Hyperprolactinemia and acromegaly were associated in 9/43 and 8/43 cases. The number of associated hypersecretions was higher in macroadenomas than in microadenomas (Chi square = 11.2, P<0.01). Two women had sporadic multiple endocrine neoplasia type 1-associated syndrome. The proportion of microadenomas versus macroadenomas was 1/11 (period 1974-1986) and 8/32 (period 1987-2001). Bilateral petrosal sinus sampling, (111)In-pentreotide scintigraphy and ((11)C)-l-methionine positron emission tomography scan confirmed diagnosis in four questionable microadenomas. Macroadenomas with extrasellar extension (31 cases) had a tendency to be medially located. Medical treatment with somatostatin analogs was initiated as first-line treatment in 26 patients. TSH levels were reduced by more than 50% in 23/26 cases. A tumoral shrinkage of more than 20% was observed in 5/13 cases. Surgery was performed in 36 patients. After 1 year, 21 of them (58.3%) met the criteria of surgical favorable outcome. Pituitary radiotherapy (n=8) and somatostatin analogs allowed normalization in cases not cured by surgery. CONCLUSION: Ultrasensitive methods for TSH measurement led to an earlier recognition of TSH-secreting pituitary tumors. In this series, we observed that TSH-secreting pituitary tumors are today more frequently found at the stage of microadenomas, medially located, without associated hypersecretions and needing new exploration methods as compared with older series. This changing spectrum in the presentation of TSH-secreting pituitary tumors and the excellent response to somatostatin analogs has been accompanied by an improvement in the prognosis of the disease. [less ▲]

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See detailLa Convention de Bruxelles
Boularbah, Hakim ULg; Nuyts, Arnaud; Watte, N.

in Journal des Tribunaux Droit Européen (2003)

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See detailBiogeography and Ecology of a dimorphic trait in Triturus alpestris (Amphibia, Caudata)
Denoël, Mathieu ULg; Duguet, Rémi; Dzukic, Georg et al

Poster (2003)

Paedomorphosis is an evolutionary process in which larval structures are retained in adult animals. In newts and salamanders, this heterochronic process is widely represented and concerns the retention of ... [more ▼]

Paedomorphosis is an evolutionary process in which larval structures are retained in adult animals. In newts and salamanders, this heterochronic process is widely represented and concerns the retention of gill slits. Our aim was to find out whether habitat and geographical determinants may be associated with paedomorphosis in a European species of newt. To this end, we determined the main characteristics of the aquatic sites containing paedomorphic Alpine newts that have been described in the literature or discovered by one of us. Although metamorphs are widely distributed in Europe, paedomorphs were only found at the southern margin of the geographic range of the species: mainly in the Italian and Balkan peninsulas. They were recorded in 87 aquatic sites. No single trend was outlined for the analyzed ecological parameters of the aquatic and surrounding terrestrial habitats (e.g. altitude, maximum water depth, drying and presence of forest). These results show that paedomorphs can be found in both favorable aquatic habitats surrounded by hostile terrestrial landscapes, but also in temporary waters located in proximity to appropriate terrestrial environments. Models predicting paedomorphosis in varied environments are thus supported, but require complementary investigations on the costs and benefits of each alternative ontogenetic pathway. On the other hand, the southern limitation of the heterochronic phenomenon and the existence of favorable sites in northern and eastern Europe suggest a genetic basis for paedomorphosis in the studied species. [less ▲]

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