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See detailBatardeaux de maintenance pour barrages mobiles: avantages et inconvénients
Rigo, Philippe ULg; Herbillon, Vincent ULg; Lizin, S. et al

in PIANC 2006, 31ème Congrès de l’PIANC, Estoril, Portugal, May 2006, (Article 083), (2006, May)

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See detailEsquivanne: Un Outil de Conception des Barrages Mobiles de Navigation
Rigo, Philippe ULg; Lizin, S.; Closset, M. P. et al

in PIANC 2006, 31ème Congrès de l’PIANC (Article 076) (2006, May)

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See detailOn the accuracy of analytical models of TCP throughput
El Khayat, Ibtissam; Geurts, Pierre ULg; Leduc, Guy ULg

in Lecture Notes in Computer Science (2006, May), 3976

Based on a large set of TCP sessions we first study the accuracy of two well-known analytical models (SQRT and PFTK) of the TCP average rate. This study shows that these models are far from being accurate ... [more ▼]

Based on a large set of TCP sessions we first study the accuracy of two well-known analytical models (SQRT and PFTK) of the TCP average rate. This study shows that these models are far from being accurate on average. Actually, our simulations show that 70% of their predictions exceed the boundaries of TCP-Friendliness, thus questioning their use in the design of new TCP-Friendly transport protocols. Our study also shows that the inaccuracy of the PFTK model is largely due to its inability to make the distinction between the two packet loss detection methods used by TCP: triple duplicate acknowledgments or timeout expirations. We then use supervised learning techniques to infer models of the TCP rate. These models show important accuracy improvements when they take into account the two types of losses. This suggests that analytical model of TCP throughput should certainly benefit from the incorporation of the timeout loss rate. [less ▲]

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See detailLe dosage de l'homocystéine intéresse-t-il le Médecin généraliste ?
Girs, Noella; Giet, Didier ULg

in Revue Médicale de Liège (2006), 61(5-6), 352-361

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See detailSuppression of limit cycle oscillations with a nonlineart energy sink: theoretical basis
Lee, Young S.; Vakakis, Alexander F.; McFarland, D. Michael et al

in 47th AIAA Structural Dynamics and Materials Conference, Newport, 2006 (2006, May)

Limit cycle oscillations (LCOs) commonly require restrictions on the operation of high- performance aircraft and have the potential to cause structural damage or failure. This paper summarizes recent ... [more ▼]

Limit cycle oscillations (LCOs) commonly require restrictions on the operation of high- performance aircraft and have the potential to cause structural damage or failure. This paper summarizes recent theoretical findings on the application of passive and targeted nonlinear energy transfer (\nonlinear energy pumping") for the reduction or elimination of LCOs in self-excited systems. This NES has been used successfully to suppress LCOs of an elastically mounted, rigid airfoil in flow. The theoretical results are in agreement with experimental studies of a practical airfoil with an attached NES. These experimental results, presented in full in a separate paper, verify the capacity of the NES to reduce or even eliminate these undesired oscillations and to extend the operating speed range of the wing. [less ▲]

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See detailFormer des professionnels de l'enseignement supérieur
Poumay, Marianne ULg

in Actes du 23e Congrès de l'AIPU (cd-rom) (2006, May)

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See detailEfficacy and tolerability of once-monthly oral ibandronate in postmenopausal osteoporosis: 2 year results from the MOBILE study
Reginster, Jean-Yves ULg; Adami, S.; Lakatos, P. et al

in Annals of the Rheumatic Diseases (2006), 65(5), 654-661

BACKGROUND: Reducing bisphosphonate dosing frequency may improve suboptimal adherence to treatment and therefore therapeutic outcomes in postmenopausal osteoporosis. Once-monthly oral ibandronate has been ... [more ▼]

BACKGROUND: Reducing bisphosphonate dosing frequency may improve suboptimal adherence to treatment and therefore therapeutic outcomes in postmenopausal osteoporosis. Once-monthly oral ibandronate has been developed to overcome this problem. OBJECTIVE: To confirm the 1 year results and provide more extensive safety and tolerability information for once-monthly dosing by a 2 year analysis. METHODS: MOBILE, a randomised, phase III, non-inferiority study, compared the efficacy and safety of once-monthly ibandronate with daily ibandronate, which has previously been shown to reduce vertebral fracture risk in comparison with placebo. RESULTS: 1609 postmenopausal women were randomised. Substantial increases in lumbar spine bone mineral density (BMD) were seen in all treatment arms: 5.0%, 5.3%, 5.6%, and 6.6% in the daily and once-monthly groups (50 + 50 mg, 100 mg, and 150 mg), respectively. It was confirmed that all once-monthly regimens were at least as effective as daily treatment, and in addition, 150 mg was found to be better (p<0.001). Substantial increases in proximal femur (total hip, femoral neck, trochanter) BMD were seen; 150 mg produced the most pronounced effect (p<0.05 versus daily treatment). Independent of the regimen, most participants (70.5-93.5%) achieved increases above baseline in lumbar spine or total hip BMD, or both. Pronounced decreases in the biochemical marker of bone resorption, sCTX, observed in all arms after 3 months, were maintained throughout. The 150 mg regimen consistently produced greater increases in BMD and sCTX suppression than the 100 mg and daily regimens. Ibandronate was well tolerated, with a similar incidence of adverse events across groups. CONCLUSIONS: Once-monthly oral ibandronate is at least as effective and well tolerated as daily treatment. Once-monthly administration may be more convenient for patients and improve therapeutic adherence, thereby optimising outcomes. [less ▲]

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See detailDes loutres dans le réseau aquifère des grottes d'Arcy-sur-Cure (Yonne)
Rosoux, René; Liger, J. C.; Libois, Roland ULg et al

in Recherches Naturalistes en Région Centre (2006), 15

La loutre peut aller pêcher loin sous terre et fréquente le milieu souterrain.

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See detailAn Analytical Cost Assessment Module for the Detailed Design Stage
Caprace, Jean-David ULg; Rigo, Philippe ULg; Warnotte, Renaud ULg et al

in Conference on Computer Applications and Information Technology in the Maritime Industries (COMPIT) (2006, May)

The main goal of the project is to implement a “real time” and automatic cost assessment model of the ship hull construction, which integrates the design criteria and production parameters. The presented ... [more ▼]

The main goal of the project is to implement a “real time” and automatic cost assessment model of the ship hull construction, which integrates the design criteria and production parameters. The presented method for short-term cost assessment promises to increase the productivity. Nowadays, cost assessment is a key task of an integrated ship design. The various methods to estimate the production cost differs with the required information (input data). The less information is needed, the earlier this method can be used in the design process. The more information is used, the better we can assess the differences between design alternatives. This means: − At the basic design stage: validate the budget and give a reliable bidding price, − At the detailed design stage:, plan the deadlines and establish the production schedule, − At the scheduling production stage: distribute the workload between the various production workshops and assess the productivity. A first prototype of cost assessment module reaches the validation stage at the Alstom Marine St Nazaire shipyard (Chantiers de l’Atlantique) within the framework of the European project InterSHIP which has partly financed the study. In the future, cost assessment will become increasing important. It is proposed to assist/help the designers by a “real time” follow-up of the cost, starting at the earliest conceptual design stage up to the latest detailed design stage. The development such a cost assessment tool requires considering simultaneously the design criteria and the production parameters. Designers will consequently be able to choose the least expensive options at each step of the design procedure (earlier is of course better). [less ▲]

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See detailIs the neutrophil a worthy target in severe asthma and chronic obstructive pulmonary disease?
Louis, Renaud ULg; Djukanovic, R.

in Clinical & Experimental Allergy : Journal of the British Society for Allergy & Clinical Immunology (2006), 36(5), 563-567

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See detailConcurrent coronary and carotid artery surgery: an open debate: reply
Kolh, Philippe ULg; Limet, Raymond ULg

in European Heart Journal (2006), 27(10), 1259-1260

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See detailDiarrhea induced by high doses of nicotinamide in dialysis patients
Delanaye, Pierre ULg; Weekers, Laurent ULg; Krzesinski, Jean-Marie ULg

in Kidney International (2006), 69(10), 1914-1914

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See detailTranscription impairment and cell migration defects in elongator-depleted cells: Implication for familial dysautonomia
Close, Pierre ULg; Hawkes, Nicola; Cornez, Isabelle ULg et al

in Molecular Cell (2006), 22(4), 521-531

Mutations in IKBKAP, encoding a subunit of Elongator, cause familial dysautonomia (FD), a severe neuro-developmental disease with complex clinical characteristics. Elongator was previously linked not only ... [more ▼]

Mutations in IKBKAP, encoding a subunit of Elongator, cause familial dysautonomia (FD), a severe neuro-developmental disease with complex clinical characteristics. Elongator was previously linked not only with transcriptional elongation and histone acetylation but also with other cellular processes. Here, we used RNA interference (RNAi) and fibroblasts from FD patients to identify Elongator target genes and study the role of Elongator in transcription. Strikingly, whereas Elongator is recruited to both target and nontarget genes, only target genes display histone H3 hypoacetylation and progressively lower RNAPII density through the coding region in FD cells. Interestingly, several target genes encode proteins implicated in cell motility. Indeed, characterization of IKAP/hELP1 RNAi cells, FD fibroblasts, and neuronal cell-derived cells uncovered defects in this cellular function upon Elongator depletion. These results indicate that defects in Elongator function affect transcriptional elongation of several genes and that the ensuing cell motility deficiencies may underlie the neuropathology of FD patients. [less ▲]

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See detailRaloxifene-induced myeloma cell apoptosis: a study of nuclear factor-kappaB inhibition and gene expression signature.
Olivier, Sabine ULg; Close, Pierre ULg; Castermans, Emilie ULg et al

in Molecular Pharmacology (2006), 69(5), 1615-1623

Because multiple myeloma remains associated with a poor prognosis, novel drugs targeting specific signaling pathways are needed. The efficacy of selective estrogen receptor modulators for the treatment of ... [more ▼]

Because multiple myeloma remains associated with a poor prognosis, novel drugs targeting specific signaling pathways are needed. The efficacy of selective estrogen receptor modulators for the treatment of multiple myeloma is not well documented. In the present report, we studied the antitumor activity of raloxifene, a selective estrogen receptor modulator, on multiple myeloma cell lines. Raloxifene effects were assessed by tetrazolium salt reduction assay, cell cycle analysis, and Western blotting. Mobility shift assay, immunoprecipitation, chromatin immunoprecipitation assay, and gene expression profiling were performed to characterize the mechanisms of raloxifene-induced activity. Indeed, raloxifene, as well as tamoxifen, decreased JJN-3 and U266 myeloma cell viability and induced caspase-dependent apoptosis. Raloxifene and tamoxifen also increased the cytotoxic response to vincristine and arsenic trioxide. Moreover, raloxifene inhibited constitutive nuclear factor-kappaB (NF-kappaB) activity in myeloma cells by removing p65 from its binding sites through estrogen receptor alpha interaction with p65. It is noteworthy that microarray analysis showed that raloxifene treatment decreased the expression of known NF-kappaB-regulated genes involved in myeloma cell survival and myeloma-induced bone lesions (e.g., c-myc, mip-1alpha, hgf, pac1,...) and induced the expression of a subset of genes regulating cellular cycle (e.g., p21, gadd34, cyclin G2,...). In conclusion, raloxifene induces myeloma cell cycle arrest and apoptosis partly through NF-kappaB-dependent mechanisms. These findings also provide a transcriptional profile of raloxifene treatment on multiple myeloma cells, offering the framework for future studies of selective estrogen receptor modulators therapy in multiple myeloma. [less ▲]

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See detailRéforme de Bologne : quelles transformations de l’évaluation des apprentissages ?
Gorga, Adriana; Charlier, Bernadette; Gilles, Jean-Luc ULg

Conference (2006, May)

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See detail2006, International Year of Deserts, Desertification and Dust
Ozer, Pierre ULg; Courel, Marie-Françoise; Goudie, Andrew S

in Africa Health (2006), 28(4), 3

Desertification ranks among the major environmental challenges of the 21st century and is defined by the United Nations Convention to Combat Desertification as ‘land degradation in arid, semiarid, and dry ... [more ▼]

Desertification ranks among the major environmental challenges of the 21st century and is defined by the United Nations Convention to Combat Desertification as ‘land degradation in arid, semiarid, and dry subhumid areas resulting from various factors, including climatic variations and human activities’. Currently, desertification affects a total area between 6 million and 12 million square kilometres and generates large loss of income, estimated at US$42 billion each year. Areas threatened by desertification occupy 34% of the Earth’s land area and are home to about 2 billion people. [...] [less ▲]

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See detailPhonological deficits in French speaking children with SLI
Maillart, Christelle ULg; Parisse, Christophe

in International Journal of Language & Communication Disorders (2006), 41(3), 253274

Background: This study investigated the phonological disorders of Frenchspeaking children with specific language impairment (SLI) in production. Aims: The main goal was to confirm whether children with ... [more ▼]

Background: This study investigated the phonological disorders of Frenchspeaking children with specific language impairment (SLI) in production. Aims: The main goal was to confirm whether children with SLI have limitations in phonological ability as compared with normally developing children matched by mean length of utterance (MLU) and phonemic inventory size. A number of researchers have obtained findings pointing in this direction, but the conclusions have never been tested on French-speaking children. The second goal was to find out whether characteristic features of the French language are reflected in the nature of the children’s phonological disorder. Methods & Procedures: The spontaneous language of 16 children with SLI and 16 control children matched on MLU and phonemic inventory size (normal language development group) were analysed using different measures bearing on utterances, words, syllables and phonemes. In both SLI and NLD groups, the children were distributed into two different subgroups based on their MLU, with controlled phonemic inventory size. Outcomes & Results: The results supported a specific limitation in the phonological abilities of French children with SLI, as has already been demonstrated for English, Hebrew, Italian and Spanish-Catalan. However, two unexpected results were also obtained. First, a significant difference between children with SLI and control children could only be found for older children (MLU.3), not for younger children with MLU,3. This was true for all measures. Conclusions: This finding highlights the importance of having a developmental perspective and needs to be confirmed through a longitudinal study. Second, deficits were much more significant at the phoneme level than at the syllable level. This may be explained by the fact that the pronunciation of syllables in French is very homogenous, making them easier to segment. [less ▲]

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