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See detailModélisation, Simulation et Optimisation d'un Atelier de Construction Navale
Bair, Frédéric ULg; Langer, Yves; Rigo, Philippe ULg

in 6ème Conférence Francophone de MOdélisation et SIMulation - MOSIM, Maroc (2006)

This study is about the simulation of a shipbuilding workshop, and its optimization in order to improve its productivity. The objective is to model precisely a complex workshop and to evaluate ... [more ▼]

This study is about the simulation of a shipbuilding workshop, and its optimization in order to improve its productivity. The objective is to model precisely a complex workshop and to evaluate possibilities to automate the optimization. The virtual model developed will be coupled with a genetic algorithm. [less ▲]

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See detailLe jugement par défaut en procédure civile
Boularbah, Hakim ULg

in Journal des Tribunaux (2006)

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See detailLes districts sanitaires : un outil pour le renforcement des systèmes de santé locaux
Porignon, Denis ULg

Scientific conference (2006)

Objectif Le présent travail vise à argumenter la pertinence des systèmes de santé de district pour la mise en place de services de santé locaux permettant la prise en charge des principaux problèmes de ... [more ▼]

Objectif Le présent travail vise à argumenter la pertinence des systèmes de santé de district pour la mise en place de services de santé locaux permettant la prise en charge des principaux problèmes de santé dans un contexte de crise. Matériel et méthodes En Afrique centrale, plusieurs faisceaux d'arguments convergents ont été développés à travers des études sur la performance de districts sanitaires dans trois contextes différents : (1) le suivi sur 17 ans des performances d'un district sanitaire de l'Est de la République démocratique du Congo (1985-2001), (2) l'analyse des performances dans 46 districts de santé dans la partie ouest de la République démocratique du Congo (2003-2004) et (3) l'analyse des performances des districts sanitaires comme pierre angulaire de la réforme sanitaire au Rwanda après la guerre et le génocide (1995-2001). Résultats Dans ces trois contextes, il est apparu que les districts de santé lorsqu'ils disposent d'un minimum de ressources en termes humains et financiers, sont capables de développer assez rapidement des niveaux de performances pour les activités de base et de référence (curatives, préventives, générales ou spécialisées) . Ces derniers sont comparables à ceux que l'on trouve dans la littérature internationale pour des pays de niveau analogue. En outre, les principes d'organisation des districts, notamment à travers les organes de participation, permettent d'envisager le rôle potentiel que les professionnels de santé peuvent jouer dans l'élaboration des processus de paix. Discussion Les différentes causes et facteurs expliquant ces observations positives sont analysés. Parmi ceux-ci, la volonté politique et la capacité humaine apparaissent comme essentielles. En conclusion, nous avons pu étayer l'hypothèse de départ et confirmer le rôle potentiel majeur que peuvent jouer les districts de santé dans le paysage actuel de la santé publique internationale, y compris en situation critique. [less ▲]

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See detailThe triple neurokinin-receptor antagonist CS-003 inhibits neurokinin A-induced bronchoconstriction in patients with asthma
Schelfhout, V.; Louis, Renaud ULg; Lenz, W. et al

in Pulmonary Pharmacology & therapeutics (2006), 19(6), 413-418

Neurokinin A (NKA) causes bronchoconstriction in asthmatic patients. In vitro both NK1 and NK2 receptors can mediate airway contraction. Moreover in guinea pigs, NK3 receptors facilitate cholinergic ... [more ▼]

Neurokinin A (NKA) causes bronchoconstriction in asthmatic patients. In vitro both NK1 and NK2 receptors can mediate airway contraction. Moreover in guinea pigs, NK3 receptors facilitate cholinergic neurotransmission. Dual tachykinin NK1/NK2 receptor antagonism results in prevention of NKA-induced bronchoconstriction. We have now examined the effect of a single dose of the triple tachykinin receptor antagonist CS-003 on NKA-induced bronchoconstriction in asthmatics. A double blind, crossover, placebo-controlled trial in 16 mild asthmatics was performed. One single dose of CS-003 (200 mg, solution in distilled water) or matched placebo was given orally on the assessment days. NKA-provocation tests were performed pre-dose and 1, 8 and 24h after dosing. There was a significant shift to the right of the dose-response curve at 1 and 8 h after intake of CS-003. PC20 was not reached in 12/16 patients at 1 h post-dose and in 5/16 patients at 8h post-dose. This did not occur under placebo treatment. A single dose of 200 mg CS-003 protected significantly against NKA-induced bronchoconstriction at 1 and 8 h post-dose in mild asthmatics. (c) 2005 Elsevier Ltd. All rights reserved. [less ▲]

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See detailHIV viraemic patients downregulate CD94/NKG2A inhibitory receptors on NK as well as CD8 T cells in comparison with aviraemic counterparts
Zeddou, Mustapha; Rahmouni, Souad ULg; VANDAMME, Arnaud ULg et al

Poster (2006)

Background: The CD94/NKG2 heterodimer is a C-type lectin receptor formed by the association of CD94 and one of the NKG2 molecules (namely NKG2A, -B, -C or –E). The interaction of CD94/NKG2A with non ... [more ▼]

Background: The CD94/NKG2 heterodimer is a C-type lectin receptor formed by the association of CD94 and one of the NKG2 molecules (namely NKG2A, -B, -C or –E). The interaction of CD94/NKG2A with non classical HLA-E molecules delivers inhibitory signals. CD94/NKG2A is normally expressed on most NK cells whereas less than 5% of peripheral resting CD8+ T cells are positive. Although several reports have clearly shown an upregulation of CD94 on CD8 T cells in HIV infection, the simultaneous expression of both subunits of the inhibitory receptor on NK and T cells and its relation with viral load is largely unknown. Methods: PBLs from 30 HIV-infected patients (16 viraemic and 14 aviraemic under HAART) and 18 healthy volunteers were analysed by flow cytometry after staining with the following monoclonal antibodies (Percp-conjugated anti-CD8, FITC-conjugated anti-CD3, APC-conjugated anti-CD94, PE-conjugated anti-NKG2A). Results: The proportion of CD8 T cells expressing the CD94/NKG2A inhibitory receptor was not significantly increased in HIV-infected patients (5.68 ± 3.72%) in comparison with non-infected controls (4.90±2.84%). Interestingly, patients with viral load < 50 copies/ml had a higher proportion of CD8 T cells expressing the inhibitory receptor (7.15 ± 3.63%) than patients with HIV viraemia (4.40 ± 3.40%), p= 0.041. The same pattern was observed for NK cells and was even more pronounced. In aviraemic individuals, 61.75 ± 20.39% of NK cells expressed the inhibitory receptor vs 42.88 ± 26.38% in viraemic patients. The proportion of CD94/NKG2A positive cells was correlated between NK and CD8 T cell subsets (p=0.0351) but there was no correlation with absolute or relative CD4 counts. Conclusions: Our results suggest that chronic stimulation with HIV antigens in viraemic patients could lead to decreased rather than increased expression of inhibitory receptors on NK and CD8 T cells. This could contribute to the abnormal activation of the immune system associated with advanced HIV disease. [less ▲]

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See detailLa PESD après l'échec constitutionnel européen
Dumoulin, André ULg

in Sur, Serge (Ed.) Annuaire français de relations internationales 2006 (2006)

La crise autour du Traité constitutionnel a épargné la Politique européenne de sécurité et de défense. Le Conseil européen va devoir néanmoins récupérer certaines avancées de la PESD qui avait été ... [more ▼]

La crise autour du Traité constitutionnel a épargné la Politique européenne de sécurité et de défense. Le Conseil européen va devoir néanmoins récupérer certaines avancées de la PESD qui avait été introduite directement dans ce document à haute valeur symbolique. Au-delà d’une visibilité pragmatique de l’UE en matière de missions civilo-militaires, la PESD pourrait être autant soutenue que fragilisée par de nouvelles configurations organiques imposées par les événements institutionnels européens : structure de coopération ad hoc, noyaux durs, cercles thématiques, union dans l’union. Toutes configurations qui complexifient la lecture d’une Union européenne « sans frontières ». [less ▲]

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See detailEtude des caractéristiques botaniques, agronomiques et de la biologie florale du melon africain (Cucumis melo L. var. agrestis Naudin, Cucurbitaceae)
Dje, Yao; Kouonon, Léonie C.; Zoro BI, Arsène I. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2006), 10(2), 109-119

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See detailDiversidad genética molecular de Mirabilis expansa mediante RAPD
Chia, J. W.; Lopez, C. B.; Blas, R. et al

in Ecologia Aplicada (2006), 5(1,2), 81-86

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See detailSpontaneous pneumocephalus caused by the association of pneumosinus dilatans and meningioma. Case illustration
Scholsem, Martin; Collignon, Frederic; Deprez, Manuel ULg et al

in Journal of Neurosurgery (2006), 105(6), 934

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See detailDefining the role of aromatase inhibitors in the adjuvant endocrine treatment of early breast cancer
BUDZAR, A.; CHLEBOWSKI, R.; CUZICK, J. et al

in Current Medical Research & Opinion (2006), 22

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See detailNew generation phase coronagraphy
Mawet, Dimitri; Riaud, Pierre; Baudrand, Jacques et al

Poster (2006)

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See detailThe ability of five radioimmunoassay systems to detect early pregnancy-associated glycoprotein in bovine plasma.
Ayad, A.; Melo de Sousa, Noelita ULg; Sulon, J. et al

in Proceedings of the 22nd Scientific Meeting of the European Embryo Transfer Association (2006)

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See detailOn the application and interpretation of Keeling plots in paleo climate research - Deciphering δ 13C of atmospheric CO 2 measured in ice cores
Köhler, Peter; Fischer, Hubertus; Schmitt, Jochen et al

in Biogeosciences (2006), 3(4), 539-556

The Keeling plot analysis is an interpretation method widely used in terrestrial carbon cycle research to quantify exchange processes of carbon between terrestrial reservoirs and the atmosphere. Here, we ... [more ▼]

The Keeling plot analysis is an interpretation method widely used in terrestrial carbon cycle research to quantify exchange processes of carbon between terrestrial reservoirs and the atmosphere. Here, we analyse measured data sets and artificial time series of the partial pressure of atmospheric carbon dioxide (pCO(2)) and of delta C-13 of CO2 over industrial and glacial/interglacial time scales and investigate to what extent the Keeling plot methodology can be applied to longer time scales. The artificial time series are simulation results of the global carbon cycle box model BICYCLE. The signals recorded in ice cores caused by abrupt terrestrial carbon uptake or release loose information due to air mixing in the firn before bubble enclosure and limited sampling frequency. Carbon uptake by the ocean cannot longer be neglected for less abrupt changes as occurring during glacial cycles. We introduce an equation for the calculation of long-term changes in the isotopic signature of atmospheric CO2 caused by an injection of terrestrial carbon to the atmosphere, in which the ocean is introduced as third reservoir. This is a paleo extension of the two reservoir mass balance equations of the Keeling plot approach. It gives an explanation for the bias between the isotopic signature of the terrestrial release and the signature deduced with the Keeling plot approach for long-term processes, in which the oceanic reservoir cannot be neglected. These deduced isotopic signatures are similar (-8.6 parts per thousand) for steady state analyses of long-term changes in the terrestrial and marine biosphere which both perturb the atmospheric carbon reservoir. They are more positive than the delta C-13 signals of the sources, e.g. the terrestrial carbon pools themselves (similar to -25 parts per thousand). A distinction of specific processes acting on the global carbon cycle from the Keeling plot approach is not straightforward. In general, processes related to biogenic fixation or release of carbon have lower y-intercepts in the Keeling plot than changes in physical processes, however in many case they are indistinguishable (e.g. ocean circulation from biogenic carbon fixation). [less ▲]

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See detailTemporal shift of diet in alternative cannibalistic morphs of the tiger salamander
Denoël, Mathieu ULg; Whiteman, Howard H.; Wissinger, Scott A.

in Biological Journal of the Linnean Society (2006), 89(2), 373-382

Evolutionary theory predicts that alternative trophic morphologies are adaptive because they allow a broad use of resources in heterogeneous environments. The development of a cannibal morphology is ... [more ▼]

Evolutionary theory predicts that alternative trophic morphologies are adaptive because they allow a broad use of resources in heterogeneous environments. The development of a cannibal morphology is expected to result in cannibalism and high individual fitness, but conflicting results show that the situation is more complex. The goal of the present study was to increase our understanding of the ultimate benefits of a cannibalistic polyphenism by determining temporal changes in the feeding habits and biomass intake in a population of tiger salamanders (Ambystoma tigrinum nebulosum). Cannibals in this species develop a larger head than typicals and have prominent teeth, both useful for consuming large prey. Although cannibalism was only detected in cannibal morphs, large temporal variation in resource partitioning was found between morphs. The two morphs always differed in their foraging habits, but cannibalism mainly occurred immediately after the ontogenetic divergence between morphs. Cannibals shifted their foraging later to a more planktivorous diet (i.e. the primarily prey of the typical morph). Cannibals also obtained more prey biomass than typicals. These results indicate that the cannibalistic morph is advantageous over the typical development, but that these advantages vary ontogenetically. Although the results obtained are consistent with models predicting the maintenance of cannibalism polyphenism in natural populations, they show that the foraging tactics utilized by cannibal morphs, and the fitness consequences accrued by such tactics, are likely to be more complex and dynamic than previous studies have suggested. (c) 2006 The Linnean Society of London. [less ▲]

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See detail"Droit des biens et sociétés : de certaines influences"
Lecocq, Pascale ULg

in Revue de la Faculté de Droit de l'Université de Liège (2006)

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See detailRetour sur le Conseil Wallon de l'Economie Sociale: quel héritage?
Defourny, Jacques ULg

in SAW-B Analyses (2006), 7

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See detailNumerical simulation of impedance and admittance of OLEDs
Nguyen, Ngoc Duy ULg; Schmeits, Marcel

in Physica Status Solidi : A. Applications and Materials Science (2006), 203

The electrical characteristics of organic light-emitting devices are calculated for the dc and ac regimes by numerically solving the basic semiconductor equations under steady-state and small-signal ... [more ▼]

The electrical characteristics of organic light-emitting devices are calculated for the dc and ac regimes by numerically solving the basic semiconductor equations under steady-state and small-signal conditions. For a given structure, the dc and ac electric potential and electric field, the electron and hole concentrations, as well as the different components of the current density are obtained as function of the one-dimensional spatial coordinate. This approach allows a detailed microscopic description of the dependencies of these quantities on the applied steady-state voltage V0 and the frequency of the modulating voltage. The final output consists in the frequency-dependent complex admittance and impedance of the device, the real and imaginary parts of which are the experimentally-available data. As a typical example, we show the results for a two-layer structure where α-NPD is the hole-transporting material and Alq3 the electron-transporting material. The anode is made of ITO and Al/LiF composes the cathode. The admittance and impedance curves, yielded by the numerical simulation as functions of the modulation frequency, are fitted by an equivalent electrical circuit, the elements of which are resistances and capacitances. The number of com- ponents depends on the structure composition and on the applied steady-state voltage. We show that each element can be associated with a particular region of the device. This allows to correlate the dependence of each feature of the admittance and impedance curves with one or several parameters describing the ma- terial system. Such an analysis can be useful for the inverse approach, where, starting from measurements of the electrical ac characteristics, the aim is to get information on the microscopic mechanisms which contribute to the electrical conduction of the device. [less ▲]

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See detailThe epileptic syndromes with continuous spikes and waves during slow sleep: definition and management guidelines.
Van Bogaert, P.; Aeby, A.; De Borchgrave, V. et al

in Acta Neurologica Belgica (2006), 106(2), 52-60

The authors propose to define the epileptic syndromes with continuous spikes and waves during slow sleep (CSWS) as a cognitive or behavioral impairment acquired during childhood, associated with a strong ... [more ▼]

The authors propose to define the epileptic syndromes with continuous spikes and waves during slow sleep (CSWS) as a cognitive or behavioral impairment acquired during childhood, associated with a strong activation of the interictal epileptiform discharges during NREM sleep--whatever focal or generalized--and not related to another factor than the presence of CSWS. The type of syndrome will be defined according to the neurological and neuropsychological deficit. These syndromes have to be classified among the localization-related epileptic syndromes. Some cases are idiopathic and others are symptomatic. Guidelines for work-up and treatment are proposed. [less ▲]

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See detailPatient Preference in the Management of Postmenopausal Osteoporosis with Bisphosphonates
Reginster, Jean-Yves ULg; Rabenda, Véronique ULg

in Clinical Interventions in Aging (2006), 1(4), 415-23

The leading treatments for postmenopausal osteoporosis are the nitrogen-containing bisphosphonates, which are required long term for optimal benefit. Oral bisphosphonates have proven efficacy in ... [more ▼]

The leading treatments for postmenopausal osteoporosis are the nitrogen-containing bisphosphonates, which are required long term for optimal benefit. Oral bisphosphonates have proven efficacy in postmenopausal osteoporosis in clinical trials, but in practice the therapeutic benefits are often compromised by patients' low adherence. Nonadherence to bisphosphonate therapy negatively impacts outcomes such as fracture rate; fractures are in turn associated with decreased quality of life. The most common reason cited by patients for their nonadherence is that the strict dosing instructions for bisphosphonates are difficult to follow. One aspect of bisphosphonate administration that can be changed is dosing frequency and several studies have evaluated patient preferences for different dosing schedules. Studies have shown a preference for a weekly bisphosphonate regimen versus daily dosing and it has been demonstrated that this preference for reduced dosing frequency impacts on adherence. Ibandronate is the first nitrogen-containing oral bisphosphonate for osteoporosis that can be administered in a monthly regimen and two robust clinical studies demonstrated a strong patient preference for this monthly regimen versus a weekly regimen. It is important that physicians consider patient preference when prescribing treatment for osteoporosis to ensure that the disease is effectively managed for the long-term benefit of the patient. [less ▲]

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See detailPhysiopathologie de l'hyperglycemie post-prandiale
Scheen, A. J.; Paquot, Nicolas ULg

in Journées Annuelles de Diabetologie de l'Hôtel-Dieu (2006)

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