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See detailRené Char et la pensée du poème
Pieron, Julien ULg

Conference given outside the academic context (2007)

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See detailAcetylcysteine and Enzymatic Creatinine: Beware of Laboratory Artefact!
Lognard, Michaël ULg; Cavalier, Etienne ULg; Chapelle, Jean-Paul ULg et al

in Intensive Care Medicine (2007)

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See detailNewly identified biologically active and proteolysis-resistant VEGF-A isoform VEGF111 is induced by genotoxic agents
Mineur, Pierre ULg; Colige, Alain ULg; Deroanne, Christophe ULg et al

in Journal of Cell Biology (2007), 179(6), 1261-1273

Ultraviolet B and genotoxic drugs induce the expression of a vascular endothelial growth factor A (VEGF-A) splice variant (VEGF111) encoded by exons 1-4 and 8 in many cultured cells. Although not detected ... [more ▼]

Ultraviolet B and genotoxic drugs induce the expression of a vascular endothelial growth factor A (VEGF-A) splice variant (VEGF111) encoded by exons 1-4 and 8 in many cultured cells. Although not detected in a series of normal human and mouse tissue, VEGF111 expression is induced in MCF-7 xenografts in nude mice upon treatment by camptothecin. The skipping of exons that contain proteolytic cleavage sites and extracellular matrix-binding domains makes VEGF111 diffusible and resistant to proteolysis. Recombinant VEGF111 activates VEGF receptor 2 (VEGF-R2) and extracellularly regulated kinase 1/2 in human umbilical vascular endothelial cells and porcine aortic endothelial cells expressing VEGF-R2. The mitogenic and chemotactic activity and VEGF111's ability to promote vascular network formation during embyonic stem cell differentiation are similar to those of VEGF121 and 165. Tumors in nude mice formed by HEK293 cells expressing VEGF111 develop a more widespread network of numerous small vessels in the peritumoral tissue than those expressing other isoforms. Its potent angiogenic activity and remarkable resistance to proteolysis makes VEGF111 a potential adverse factor during chemotherapy but a beneficial therapeutic tool for ischemic diseases. [less ▲]

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See detailAn insertion-deletion polymorphism in the Interferon Regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases
Dideberg, Vinciane ULg; Kristjansdottir, G.; Milani, L. et al

in Human Molecular Genetics (2007), 16(24), 3008-3016

The interferon regulatory factor 5 (IRF5) gene encodes a transcription factor that plays an important role in the innate as well as in the cell-mediated immune responses. The IRF5 gene has been shown to ... [more ▼]

The interferon regulatory factor 5 (IRF5) gene encodes a transcription factor that plays an important role in the innate as well as in the cell-mediated immune responses. The IRF5 gene has been shown to be associated with systemic lupus erythematosus and rheumatoid arthritis. We studied whether the IRF5 gene is also associated with inflammatory bowel diseases (IBD), Crohn disease (CD) and ulcerative colitis (UC). Twelve polymorphisms in the IRF5 gene were genotyped in a cohort of 1007 IBD patients (748 CD and 254 UC) and 241 controls from Wallonia, Belgium. The same polymorphisms were genotyped in a confirmatory cohort of 311 controls and 687 IBD patients (488 CD and 192 UC) from Leuven, Belgium. A strong signal of association [P=1.9x10(-5), odds ratio (OR) 1.81 (1.37-2.39)] with IBD was observed for a 5 bp indel (CGGGG) polymorphism in the promoter region of the IRF5 gene. The association was detectable also in CD patients (P=6.8x10(-4)) and was particularly strong among the UC patients [P=5.3x10(-8), OR=2.42 (1.76-3.34)]. The association of the CGGGG indel was confirmed in the second cohort [P=3.2x10(-5), OR=1.59 (1.28-1.98)]. The insertion of one CGGGG unit is predicted to create an additional binding site for the transcription factor SP1. Using an electrophoretic mobility shift assay, we show allele-specific differences in protein binding to this repetitive DNA-stretch, which suggest a potential function role for the CGGGG indel. [less ▲]

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See detailRecombinant gp350 vaccine for infectious mononucleosis: A phase 2, randomized, double-blind, placebo-controlled trial to evaluate the safety, immunogenicity, and efficacy of an Epstein-Barr virus vaccine in healthy young adults
Sokal, E. M.; Hoppenbrouwers, K.; Vandermeulen, C. et al

in Journal of Infectious Diseases (2007), 196(12), 1749-1753

Background. To date, there is no commercially available vaccine to prevent infectious mononucleosis, a disease frequently induced by Epstein-Barr virus (EBV) infection in adolescents or adults devoid of ... [more ▼]

Background. To date, there is no commercially available vaccine to prevent infectious mononucleosis, a disease frequently induced by Epstein-Barr virus (EBV) infection in adolescents or adults devoid of preexisting immunity to the virus. Methods. A total of 181 EBV-seronegative, healthy, young adult volunteers were randomized in a double-blind fashion to receive either placebo or a recombinant EBV subunit glycoprotein 350 (gp350)/aluminum hydroxide and 3-O-desacyl-4'-monophosphoryl lipid A (AS04) candidate vaccine in a 3-dose regimen. Results. The vaccine had demonstrable efficacy (mean efficacy rate, 78.0% [95% confidence interval {CI}, 1.0% -96.0%]) in preventing the development of infectious mononucleosis induced by EBV infection, but it had no efficacy in preventing asymptomatic EBV infection. One month after receipt of the final dose of gp350 vaccine, 98.7% of subjects showed seroconversion to anti-gp350 antibodies (95% CI, 85.5%-97.9%), and they remained anti-gp350 antibody positive for > 18 months. Furthermore, there were no concerns regarding the safety or reactogenicity of the gp350/AS04 vaccine. Conclusion. These data support the clinical feasibility of using an EBV vaccine to prevent infectious mononucleosis. [less ▲]

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See detailMetallo-beta-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily
Bebrone, Carine ULg

in Biochemical Pharmacology (2007), 74(12), 1686-1701

One strategy employed by bacterial strains to resist beta-lactam antibiotics is the expression of metallo-beta-lactamases requiring Zn+2 for activity. In the last few years, many new zinc beta-lactamases ... [more ▼]

One strategy employed by bacterial strains to resist beta-lactam antibiotics is the expression of metallo-beta-lactamases requiring Zn+2 for activity. In the last few years, many new zinc beta-lactamases have been described and several pathogens are now known to synthesize members of this class. Metallo-beta-lactamases are especially worrisome due to: (1) their broad activity profiles that encompass most beta-lactam antibiotics, including the carbapenems; (2) potential for horizontal transference; and (3) the absence of clinically useful inhibitors. on the basis of the known sequences, three different lineages, identified as subclasses B1, B2, and B3 have been characterized. The three-dimensional structure of at least one metallo-p-lactamase of each subclass has been solved. These very similar 3D structures are characterized by the presence of an alpha beta beta alpha-fold. In addition to metallo-beta-lactamases which cleave the amide bond of the beta-lactam ring, the metallo-beta-lactamase superfamily includes enzymes which hydrolyze thiol-ester, phosphodiester and sulfuric ester bonds as well as oxydoreductases. Most of the 6000 members of this superfamily share five conserved motifs, the most characteristic being the His116-X-His118-X-Asp120-His121 signature. They all exhibit an alpha beta beta alpha-fold, similar to that found in the structure of zinc beta-lactamases. Many members of this superfamily are involved in mRNA maturation and DNA reparation. This fact suggests the hypothesis that metallo-beta-lactamases may be the result of divergent evolution starting from an ancestral protein which did not have a beta-lactamase activity. (c) 2007 Elsevier Inc. All rights reserved. [less ▲]

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See detailLes temporalités véridictoires dans la photo de sport
Dondero, Maria Giulia ULg

in Nouveaux Actes Sémiotiques (2007, December 14)

La première partie de cet article approche le problème de la véridiction de l’image et du jugement épistémique en prenant en considération la relation entre la textualité photographique et ses pratiques ... [more ▼]

La première partie de cet article approche le problème de la véridiction de l’image et du jugement épistémique en prenant en considération la relation entre la textualité photographique et ses pratiques de production et de réception. On porte l’attention sur le fait que la textualité, qu’elle soit ou non photographique, ne peut pas être étudiée uniquement à partir de ses configurations plastiques et figuratives et de la constatation d’une cohérence sémiotique interne à l’image. En effet sa signification dépend fortement de ses pratiques productives (ou mieux encore de ce qu’on connaît des pratiques productives), de ses dispositifs « présentationnels » (comme par exemple l’album de famille, les affiches, la presse, Internet, etc.), de ses statuts (scientifique, documentaire, testimoniale, artistique, publicitaire) et de son histoire interprétative. La seconde partie de l’article analyse les stratégies énonciatives d’un reportage sportif, les Jeux Olympiques d’été de 2004 à Athènes. Le corpus d’images pris en considération construit différentes configurations de point de vue et diverses manières de mettre en présence de l’observateur le corps de l’athlète : des corps en action, des corps fatigués, des corps en équilibre, des corps concentrés, des corps tendant vers le but, enfin des corps avec lesquels nous construisons une « relation inhérente » grâce à une saisie analogisante. Nous avons ainsi individualisé trois types de mise en présence du corps et trois types de temps présent. Dans le premier type de présent, appelé dimensionné, le mouvement corporel entre en résonance avec la « traînée » des moments retenus et la « protension » de ceux qui se profilent comme possibles ; le second type est un présent d’appariement : dans ce deuxième cas l’exploration perceptive du photographe et du récepteur de l’image se coordonnent avec l’alternance des « points d’attaque » synchronisés des corps dansants. Le troisième type de présent, intervalle-échantillon, enfin, construit l’athlète en tant qu’identité et conscience en acte. [less ▲]

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See detailAnalyse pluviométrique au Niger : récentes modifications et impacts environnementaux. Focus sur la région de Gouré, Niger oriental.
Ozer, Pierre ULg

Conference (2007, December 13)

Depuis la fin des années 1960, la région sahélienne est touchée par une terrible sécheresse. Cet article analyse les variations climatiques enregistrées dans la région de Gouré, Niger oriental, entre 1936 ... [more ▼]

Depuis la fin des années 1960, la région sahélienne est touchée par une terrible sécheresse. Cet article analyse les variations climatiques enregistrées dans la région de Gouré, Niger oriental, entre 1936 et 2003. Il apparaît que la zone étudiée est sortie de la « Grande Sécheresse » à la fin des années 1980. Cependant, les conséquences de ce retour à des conditions plus humides ne se seraient pas accompagné d’une amélioration significative de la longueur de la saison des pluies. [less ▲]

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See detailLes Chinois croient au Père Noël
Ozer, Pierre ULg; Perrin, Dominique ULg

Article for general public (2007)

En cette période de Noël, nous devons être lucides et réfléchir à l’avenir que nos choix de consommation nous préparent. [...]

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See detailQuoi de neuf sous le soleil ? Kojève et la politique de l'actualité.
Bolmain, Thomas ULg

Scientific conference (2007, December 12)

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See detailCauses et mécanismes de la perte de l’aptitude au fractionnement du maïs séché à haute température
Malumba Kamba, Paul ULg; Deroanne, Claude; Masimango, Thaddée et al

Poster (2007, December 10)

Le séchage par entrainement d’air chaud dénature les principales familles des protéines du maïs, ce qui entraine la diminution de leur solubilité. Les températures élevées de séchage induisent également ... [more ▼]

Le séchage par entrainement d’air chaud dénature les principales familles des protéines du maïs, ce qui entraine la diminution de leur solubilité. Les températures élevées de séchage induisent également une diminution de l’aptitude à l’imprégnation d’eau des grains lors du trempage des maïs avec pour conséquence la diminution du ramollissement des grains, ce qui occasionne des moutures imparfaites et une réduction de la libération des granules d’amidon lors des phases de séparation de l’amidon et des protéines. La fonction logistique à deux asymptotes permet une meilleure prévision des rendements d’extraction de l’amidon et des quantités des glutens récoltées au tamisage en fonction de la température du séchage. [less ▲]

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See detailL'enfermement des enfants
Mormont, Christian ULg

Conference given outside the academic context (2007)

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See detailConciliation qualité de vie au travail et qualité de vie en général
Etienne, Anne-Marie ULg

Conference (2007, December 07)

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See detailLiaison autoroutière « CHB » : la Wallonie s’empêtre dans des choix dépassés
Lamarche, Caroline; Leprince, Pierre ULg; Outers, Jean-Luc et al

Article for general public (2007)

Magnétique, l'affiche mobilisatrice pour la marche « Ensemble pour le climat et la solidarité » de ce 8 décembre à Bruxelles, ces humains nus convergeant vers notre planète à protéger. Superbe symbole qui ... [more ▼]

Magnétique, l'affiche mobilisatrice pour la marche « Ensemble pour le climat et la solidarité » de ce 8 décembre à Bruxelles, ces humains nus convergeant vers notre planète à protéger. Superbe symbole qui ne doit pas nous faire oublier l'avertissement placé en tête d'affiche : « Ça commence ici ». « Ici », on nous le répète, c'est ma maison où je peux fermer le robinet, visser des ampoules économiques, baisser le chauffage, placer du double vitrage. Mais il y a un autre « ici » : notre beau coin d'Europe, nos villes et nos campagnes. Et là, pour Noël, le gouvernement wallon s'apprête à déposer un énorme cadeau dans nos petits souliers. Un truc neuf ? Non, vieux de presque un demi-siècle. Pas trop crade ? De luxe au contraire : 400 millions d'euros. Au moment de la conférence de Bali sur le changement climatique, ça a à voir avec le climat ? Mais oui ! Et c'est… ? Un permis de construire. Des canaux, des voies ferrées, des trams ? Non. Une nouvelle autoroute. [...] [less ▲]

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See detailDarwin: required performance (invited)
Absil, Olivier ULg

Scientific conference (2007, December 06)

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See detailFrom the numerisation of the Soil Map of Wallonia to a real information and management tool
Legrain, Xavier ULg; Bah, Boubacar Billo ULg; Veron, Philippe et al

Poster (2007, December 05)

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See detailNulling interferometry: performance comparison between Antarctica and other ground-based sites
Absil, Olivier ULg; Coudé Du Foresto, V.; Barillot, M. et al

in Astronomy and Astrophysics (2007), 475

Context: Detecting the presence of circumstellar dust around nearby solar-type main sequence stars is an important pre-requisite for the design of future life-finding space missions such as ESA's Darwin ... [more ▼]

Context: Detecting the presence of circumstellar dust around nearby solar-type main sequence stars is an important pre-requisite for the design of future life-finding space missions such as ESA's Darwin or NASA's Terrestrial Planet Finder (TPF). The high Antarctic plateau may provide appropriate conditions to perform such a survey from the ground. Aims: We investigate the performance of a nulling interferometer optimised for the detection of exozodiacal discs at Dome C, on the high Antarctic plateau, and compare it to the expected performance of similar instruments at temperate sites. Methods: Based on the currently available measurements of the atmospheric turbulence characteristics at Dome C, we adapt the GENIEsim software (Absil et al. 2006, A&A, 448, 787) to simulate the performance of a nulling interferometer on the high Antarctic plateau. To feed a realistic instrumental configuration into the simulator, we propose a conceptual design for ALADDIN, the Antarctic L-band Astrophysics Discovery Demonstrator for Interferometric Nulling. We assume that this instrument can be placed above the 30-m thick boundary layer, where most of the atmospheric turbulence originates. Results: We show that an optimised nulling interferometer operating on a pair of 1-m class telescopes located 30 m above the ground could achieve a better sensitivity than a similar instrument working with two 8-m class telescopes at a temperate site such as Cerro Paranal. The detection of circumstellar discs about 20 times as dense as our local zodiacal cloud seems within reach for typical Darwin/TPF targets in an integration time of a few hours. Moreover, the exceptional turbulence conditions significantly relax the requirements on real-time control loops, which has favourable consequences on the feasibility of the nulling instrument. Conclusions: The perspectives for high dynamic range, high angular resolution infrared astronomy on the high Antarctic plateau look very promising. [less ▲]

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See detailDetermination du profil en acides gras du lait par spectroscopie moyen infrarouge.
Dehareng, Frédéric; Soyeurt, Hélène ULg; Veselko, Didier et al

in 14 emes Recontres autour des recherches sur les ruminants, Paris, les 5et 6 Decembre 2007 (2007, December 01)

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See detailTitan airglow spectra from Cassini Ultraviolet Imaging Spectrograph (UVIS): EUV analysis
Ajello, Joseph M.; Stevens, Michael H.; Stewart, Ian et al

in Geophysical Research Letters (2007), 34

We present the first UV airglow observations of Titan's atmosphere by the Ultraviolet Imaging Spectrograph (UVIS) on Cassini. Using one spectral channel in the EUV from 561-1182 Å and one in the FUV from ... [more ▼]

We present the first UV airglow observations of Titan's atmosphere by the Ultraviolet Imaging Spectrograph (UVIS) on Cassini. Using one spectral channel in the EUV from 561-1182 Å and one in the FUV from 1115-1913 Å, UVIS observed the disk on 13 December, 2004 at low solar activity. The EUV spectrum consists of three band systems of N[SUB]2[/SUB] (b [SUP]1[/SUP]∏[SUB]u[/SUB], b' [SUP]1[/SUP]∑[SUB]u[/SUB] [SUP]+[/SUP], c[SUB]4[/SUB]' [SUP]1[/SUP]∑[SUB]u[/SUB] [SUP]+[/SUP] -> X [SUP]1[/SUP]∑[SUB]g[/SUB] [SUP]+[/SUP]), while the FUV spectrum consists of one (a [SUP]1[/SUP]∏[SUB]g[/SUB] -> X [SUP]1[/SUP]∑[SUB]g[/SUB] [SUP]+[/SUP]). Both the EUV and FUV spectra contain many N I and N II multiplets that are produced primarily by photodissociative ionization. Spectral intensities of the N[SUB]2[/SUB] c[SUB]4[/SUB]' [SUP]1[/SUP]∑[SUB]u[/SUB] [SUP]+[/SUP](v' = 0) -> X [SUP]1[/SUP]∑[SUB]g[/SUB] [SUP]+[/SUP](v'' = 0-2) progression from 950-1010 Å are resolved for the first time. The UVIS observations reveal that the c[SUB]4[/SUB]' [SUP]1[/SUP]∑[SUB]u[/SUB] [SUP]+[/SUP](0) -> X [SUP]1[/SUP]∑[SUB]g[/SUB] [SUP]+[/SUP] (0) vibrational band near 958 Å is weak and undetectable, and that N I multiplets near 953.2 and 964.5 Å are present instead. Magnetospheric particle excitation may be weak or sporadic, since the nightside EUV spectrum on this orbit shows no observable nitrogen emission features and only H Ly-β. [less ▲]

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