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See detailNew trends in flood risk analysis: working with 2D flow models, laser DEM and a GIS environment
Archambeau, Pierre ULg; Dewals, Benjamin ULg; Erpicum, Sébastien ULg et al

in Greco, M.; Carravetta, A.; Della Morte, R. (Eds.) Proceedings of the 2nd International Conference on Fluvial Hydraulics: River Flow 2004 (2004)

This paper outlines the integration of new and accurate laser DEM into the determination of floodplains. Global and robust GIS environment is absolutely necessary to manage this very large amounts of ... [more ▼]

This paper outlines the integration of new and accurate laser DEM into the determination of floodplains. Global and robust GIS environment is absolutely necessary to manage this very large amounts of topographic data. The development and interaction of 2D flow models, simplified or not, ensures to offer more accurate and flexible physically based tools to the decision-makers. [less ▲]

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See detailArthur Schitzler (1862-1931): Fräulein Else
Letawe, Céline ULg

in Arte Buchtipp, Reihe Junge Literaturkritik (2004)

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See detailLe medicament du mois. Rosuvastatine (Crestor).
Scheen, André ULg

in Revue Médicale de Liège (2004), 59(1), 56-9

Rosuvastatin (Crestor) has been recently launched in Belgium by AstraZeneca. This new statin is indicated for the treatment of primary hypercholesterolaemia or combined dyslipidaemia, when changes in ... [more ▼]

Rosuvastatin (Crestor) has been recently launched in Belgium by AstraZeneca. This new statin is indicated for the treatment of primary hypercholesterolaemia or combined dyslipidaemia, when changes in dietary habits are insufficient. Direct comparative randomised clinical trials with other statins demonstrated that rosuvastatin exerts a more favourable impact on lipid profile. When compared on a mg basis to other statins, rosuvastatin is associated with a greater reduction in total and LDL cholesterol levels and a greater increase of HDL cholesterol concentration, with a similar decrease in triglyceride levels. At the usual dosage of 10 mg, rosuvastatin allowed to reduce LDL cholesterol below recommended target levels for at risk patients among almost 80% of treated individuals in phase III clinical trials. If necessary, the daily dosage may be increased to 20 mg, or up to 40 mg (maximal dose), mostly in case of severe familial hypercholesterolaemia. Safety profile is good and similar to that of other commercialised statins. Rosuvastatin is currently evaluated in an extensive programme of randomised clinical trials (Galaxy programme) in order to demonstrate its efficacy in both prevention of atherosclerosis and reduction of cardiovascular morbidity and mortality. [less ▲]

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See detailStudy of the cooling process of an extruded aluminium profile
Bouffioux, Chantal ULg; Carton, Marc ULg; Lecomte-Beckers, Jacqueline ULg et al

in Gosh, Somnath; Castro, Jose M.; Lee, June K. (Eds.) Proceedings of Materials Processing and Design: Modeling, Simulation and Applications (NUMIFORM 2004) (2004)

The prediction of the final axial stresses and the residual strains of complex extruded aluminium profiles requires a good knowledge of the material behavior and of the industrial process. This paper is ... [more ▼]

The prediction of the final axial stresses and the residual strains of complex extruded aluminium profiles requires a good knowledge of the material behavior and of the industrial process. This paper is focused on the methods required to provide the whole set of data: material ones and process ones. Scanning differential calorimetry, dilatometry and diffusivity tests identify thermophysic material properties and hot tensile tests identify parameters of the elastovisco- plastic Norton-Hoff law. The description of the industrial process and its simulations are described. Then a sensitivity analyzis provides the cooling key parameters causing the undesired final curvature during the industrial process. [less ▲]

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See detailThe crustacean scavenger guild in Antarctic shelf, bathyal and abyssal communities
De Broyer, Claude; Nyssen, Fabienne ULg; Dauby, Patrick ULg

in Deep-Sea Research Part II, Topical Studies in Oceanography (2004), 51(14-16), 1733-1752

Peracarid crustaceans form a significant part of the macrobenthic community that is responsible for scavenging on large food falls onto the sea floor. Although several studies are available about ... [more ▼]

Peracarid crustaceans form a significant part of the macrobenthic community that is responsible for scavenging on large food falls onto the sea floor. Although several studies are available about scavengers from tropical and temperate seas, very little information has been published about such species living in Antarctic waters, particularly at greater depths. The present paper is based on a collection of 31 baited trap sets deployed in the Weddell Sea, Scotia Sea, and off the South Shetland Islands, and presents results on the geographical and bathymetric distribution of the different taxa and on the eco-functional role of scavengers. <br /> <br />Some 68,000 peracarid crustaceans from 62 species were collected. About 98% of individuals belonged to the amphipod superfamily Lysianassoidea, and 2% to the isopod family Cirolanidae. Of these species, 31, including 26 lysianassoids (1400 individuals), were collected deeper than 1000 m. <br /> <br />High species richness was discerned for the eastern Weddell Sea shelf compared with other Antarctic areas. The Antarctic slope also seems to be richer in species than other areas investigated in the world, while in the abyss, scavenger species richness appears to be lower in Antarctica. A richness gradient was thus observed from the shelf to the deep. For amphipods, a number of species extend their distribution from the shelf to the slope and only one to the abyssal zone. <br /> <br />Amphipod species showed degrees of adaptation to necrophagy. The functional adaptations of the mandible and the storage function of the gut are discussed. Feeding experiments conducted on lysianassoid species collected at great depths and maintained in aquaria showed a mean feeding rate of about 1.4–4.1% dry body weight day−1, which is consistent with data obtained from other species. [less ▲]

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See detailLe sourire de Marcel La Haye
Purnelle, Gérald ULg

in La Haye, Marcel (Ed.) Poésies (2004)

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See detailNovel types of mutation responsible for the dermatosparactic type of Ehlers-Danlos syndrome (Type VIIC) and common polymorphisms in the ADAMTS2 gene.
Colige, Alain ULg; Nuytinck, Lieve; Hausser, Ingrid et al

in The Journal of investigative dermatology (2004), 123(4), 656-63

Ehlers-Danlos syndrome (EDS) type VIIC, or dermatosparactic type, is a recessively inherited connective tissue disorder characterized, among other symptoms, by an extreme skin fragility resulting from ... [more ▼]

Ehlers-Danlos syndrome (EDS) type VIIC, or dermatosparactic type, is a recessively inherited connective tissue disorder characterized, among other symptoms, by an extreme skin fragility resulting from mutations inactivating ADAMTS-2, an enzyme excising the aminopropeptide of procollagens type I, II, and III. All previously described mutations create premature stop codons leading to a marked reduction in the level of mRNA. In this study, we analyzed the ADAMTS2 cDNA sequences from five patients displaying clinical and/or biochemical features consistent with a diagnosis of either typical or potentially mild form of EDS type VIIC. Three different alterations were detected in the two patients with typical EDS type VIIC. The first patient was homozygous for a genomic deletion causing an in-frame skipping of exons 3-5 in the transcript. In the second patient, the allele inherited from the mother lacks exon 3, generating a premature stop codon, whereas the paternal allele has a genomic deletion resulting in an in-frame skipping of exons 14-16 at the mRNA level. Although the exons 3-5 or 14-16 encode protein domains that have not been previously recognized as crucial for ADAMTS-2 activity, the aminoprocollagen processing was strongly impaired in vitro and in vivo, providing evidence for the requirement of these domains for proper enzyme function. The three other patients with a phenotype with some resemblance to EDS type VIIC only had silent and functionally neutral variations also frequently found in a normal population. [less ▲]

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See detailExperimental study of the charring rate of tropical hardwoods
Njankouo, Jacques Michel; Dotreppe, Jean-Claude ULg; Franssen, Jean-Marc ULg

in Fire & Materials (2004), 28(1, JAN-FEB), 15-24

This paper describes an experimental investigation of the charring rates of timber. An experimental procedure was designed for assessing the charring rate of 20 specimens exposed to fire in a single test ... [more ▼]

This paper describes an experimental investigation of the charring rates of timber. An experimental procedure was designed for assessing the charring rate of 20 specimens exposed to fire in a single test, with one-dimensional heat transfer conditions. Each test specimen was manufactured by gluing seven laminates together. Four thermocouples were inserted at different depths in four different laminates located in the middle of the test specimen. The test was conducted using a gas-fired furnace and specimens were exposed to the standard ISO 834 fire. In order to evaluate the fire performance of tropical hardwoods, seven different species with densities ranging from 500 to 1000 kg/m(3) were used. For the purpose of verifying the experimental procedure against existing data, two softwood species (spruce and fir) and one European hardwood species (oak) were also examined. Experimental results indicate that the test method and procedure can be used for assessing the charring rate of timber both for softwood and for hardwood species. They also show that the density of wood significantly affects the charring rate and that the values recommended in Eurocode 5 for high densities are somewhat too conservative. Copyright (C) 2004 John Wiley Sons, Ltd. [less ▲]

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See detailTreillis des sous-algèbres et opérateurs sur les MV-algèbres
Teheux, Bruno ULg

Master of advanced studies dissertation (2004)

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See detailIn vitro evaluation of glutathione peroxidase (GPx)-like activity and antioxidant properties of some Ebselen analogues
Mouithys-Mickalad, Ange ULg; Mareque-Faez, Juan; Chistiaens, U. et al

in Redox Report : Communications in Free Radical Research (2004), 9(2), 81-87

Four analogues of Ebselen were synthesized and their glutathione peroxidase activity and antioxidant property evaluated and compared to Ebselen. Among the studied compounds, only diselenide [3] exhibited ... [more ▼]

Four analogues of Ebselen were synthesized and their glutathione peroxidase activity and antioxidant property evaluated and compared to Ebselen. Among the studied compounds, only diselenide [3] exhibited both glutathione peroxidase activity and radical-scavenging capability. Compounds [3] and [4] showed a strong inhibitory effect (53% and 43%, respectively) on the lipid peroxidation of linoleic acid compared to Ebselen and selenide derivatives ([1] and [2]) which were less active (28%, 26% and 18% inhibition, respectively). A concentration-dependent inhibitory effect was also found in the model of the formation of ABTS*+ radical cation: 65% and 89% inhibition for compound [3] at 10(-4) M and 5 x 10(-5) M, respectively, and 68% and 90% for compound [4], compared to 14% and 52% inhibition for Ebselen and the diselenides [1] and [2] (29%, 46% and 45%, 68%, respectively). By EPR spin trapping technique, the following inhibitory profile of the Ebselen analogues was observed towards the formation of thiyl radicals: Ebselen = [3]>[1]>[2]>[4]. Studies with compound [3] are in progress on oxidative stress cell models. [less ▲]

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See detailAgir de manière socialement responsable: la richesse d'une approche par les parties prenantes
Xhauflair, Virginie ULg

in Entreprise Ethique (2004), 21(octobre), 105-111

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See detailAnalyse des prix de ventes des bois en forêts publiques
Sanchez Christine; Hebert, Jacques ULg; Rondeux, Jacques ULg

in Forêt Wallonne (2004), 73

La détermination des prix unitaires en euro/m³ reste très empirique et est souvent basée sur un nombre réduit de lots réputés représentatifs. La méthode proposée utilise des outils statistiques qui ... [more ▼]

La détermination des prix unitaires en euro/m³ reste très empirique et est souvent basée sur un nombre réduit de lots réputés représentatifs. La méthode proposée utilise des outils statistiques qui valorisent au maximum les informations disponibles. Elle a été intégrée dans une application informatique à la disposition des gestionnaires de la forêt publique. [less ▲]

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See detailConcomitant coronary and carotid artery surgery: operative outcome and long-term results
Kolh, Philippe ULg; Tchana-Sato, Vincent ULg; Honoré, Charles ULg et al

in European Heart Journal (2004), 25(Suppl. S), 360-361

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See detailSustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer
Yu, P. W.; Tabuchi, R. S.; Kato, R. M. et al

in Blood (2004), 104(5), 1281-90

X-linked agammaglobulinemia (XLA) is a human immunodeficiency caused by mutations in Bruton tyrosine kinase (Btk) and characterized by an arrest in early B-cell development, near absence of serum ... [more ▼]

X-linked agammaglobulinemia (XLA) is a human immunodeficiency caused by mutations in Bruton tyrosine kinase (Btk) and characterized by an arrest in early B-cell development, near absence of serum immunoglobulin, and recurrent bacteria infections. Using Btk- and Tec-deficient mice (BtkTec-/-) as a model for XLA, we determined if Btk gene therapy could correct this disorder. Bone marrow (BM) from 5-fluorouracil (5FU)-treated BtkTec-/- mice was transduced with a retroviral vector expressing human Btk and transplanted into BtkTec-/- recipients. Mice engrafted with transduced hematopoietic cells exhibited rescue of both primary and peripheral B-lineage development, revocery of peritoneal B1 B cells, and correction of serum immunoglobulin M (IgM) and IgG3 levels. Gene transfer also restored T-independent type II immune responses, and B-cell antigen receptor (BCR) proliferative responses. B-cell progenitors derived from Btk-transduced stem cells exhibited higher levels of Btk expression than non-B cells; and marking studies demonstrated a selective advantage for Btk-transduced B-lineage cells. BM derived from primary recipients also rescued Btk-dependent function in secondary hosts that had received a transplant. Together, these data demonstrate that gene transfer into hematopoietic stem cells can reconstitute Btk-dependent B-cell development and function in vivo, and strongly support the feasibility of pursuing Btk gene transfer for XLA. [less ▲]

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See detailAffect et strategies d'approche/evitement
Grégoire, Christine; Dardenne, Benoît ULg

in Revue Internationale de Psychologie Sociale = International Review of Social Psychology (2004), 17(1), 111-144

Après avoir présenté certaines conceptions de l'approche et de l'évitement en tant que régulateurs du comportement humain, nous défendons l'idée que les individus ressentant des affects positifs ... [more ▼]

Après avoir présenté certaines conceptions de l'approche et de l'évitement en tant que régulateurs du comportement humain, nous défendons l'idée que les individus ressentant des affects positifs développent une stratégie d'approche en situation sociale. Sur base de la théorie du «feeling-as-information» (Schwarz & Clore, 1988), l'affect peut être vu comme une information contextuelle sur l'environnement. L'information selon laquelle l'environnement ne pose pas de problème conduit les individus ressentant des affects positifs à adopter un comportement adapté vis-à-vis d'autrui et des situations sociales, alors que l'information selon laquelle l'environnement est menaçant conduit les individus ressentant des affects négatifs à davantage éviter autrui et les situations sociales. Nous illustrons notre propos par des recherches traitant de la quantité et de la qualité des activités sociales, ainsi que des comportements prosociaux. [less ▲]

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See detailSelf-assembling of poly(-caprolactone)-b-poly(ethylene oxide) diblock copolymers in aqueous solution and at the silica–water interface
Leyh, Bernard ULg; Vangeyte, Patrick; Heinrich, M. et al

in Physica B: Condensed Matter (2004), 350(1-3, suppl. 1), 901-904

Small-angle neutron scattering is used to investigate the self-assembling behaviour of poly( ε-caprolactone)-b-poly(ethylene oxide) diblock copolymers with various block lengths (i) in aqueous solution ... [more ▼]

Small-angle neutron scattering is used to investigate the self-assembling behaviour of poly( ε-caprolactone)-b-poly(ethylene oxide) diblock copolymers with various block lengths (i) in aqueous solution, (ii) in aqueous solution with the addition of sodium dodecyl sulphate (SDS) and (iii) at the silica-water interface. Micelles are observed under our experimental conditions due to the very small critical micellar concentration of these copolymers (0.01 g/l). The poly( ε-caprolactone) core is surrounded by a poly(ethylene oxide) corona. The micellar form factors have been measured at low copolymer concentrations (0.2 wt%) under selected contrast matching conditions. The data have been fitted to various analytical models to extract the micellar core and corona sizes. SDS is shown to induce partial micelle disruption together with an increase of the poly(ethylene oxide) corona extension from 25% (without SDS) to 70% (with SDS) of a completely extended PEOi u chain. Our data at the silica-water interface are compatible with the adsorption of micelles. [less ▲]

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