L'hypothyroidie subclinique.

in Revue Médicale de Liège (1995), 50(4), 171-4

L'hypothiroïdie subclinique associe, chez des patients asymptomatiques, une élévation de la TSH sérique et une hormonologie thyroïdienne dans les limites de la normale. Le traitement de cette pathologie ... [more ▼]

L'hypothiroïdie subclinique associe, chez des patients asymptomatiques, une élévation de la TSH sérique et une hormonologie thyroïdienne dans les limites de la normale. Le traitement de cette pathologie affectant surtout les personnes âgées est justifié par l'existence de troubles du bilan lipidique, de goitres et de perturbations neuropsychologiques. Celui-ci repose sur l'administration de lévothyroxine à dose minimale pour normaliser la TSH [less ▲]

Evidence for a Second Receptor Binding Site on Human Prolactin

in Journal of Biological Chemistry (1994), 269(51), 32598-606

The existence of a second receptor binding site on human prolactin (hPRL) was investigated by site-directed mutagenesis. First, 12 residues of helices 1 and 3 were mutated to alanine. Since none of the ... [more ▼]

The existence of a second receptor binding site on human prolactin (hPRL) was investigated by site-directed mutagenesis. First, 12 residues of helices 1 and 3 were mutated to alanine. Since none of the resulting mutants exhibit reduced bioactivity in the Nb2 cell proliferation bioassay, the mutated residues do not appear to be functionally necessary. Next, small residues surrounding the helix 1-helix 3 interface were replaced with Arg and/or Trp, the aim being to sterically hinder the second binding site. Several of these mutants exhibit only weak agonistic properties, supporting our hypothesis that the channel between helices 1 and 3 is involved in a second receptor binding site. We then analyzed the antagonistic and self-antagonistic properties of native hPRL and of several hPRLs analogs altered at binding site 1 or 2. Even at high concentrations (approximately 10 microM), no self-inhibition was observed with native hPRL; site 2 hPRL mutants self-antagonized while site 1 mutants did not. From these data, we propose a model of hPRL-PRL receptor interaction which slightly differs from that proposed earlier for the homologous human growth hormone (hGH) (Fuh, G., Cunningham, B. C., Fukunaga, R., Nagata, S., and Goeddel, D. V., and Well, J. A. (1992) Science 256, 1677-1680). Like hGH, hPRL would bind sequentially to two receptor molecules, first through site 1, then through site 2, but we would expect the two sites of hPRL to display, unlike the two binding sites of hGH, about the same binding affinity, thus preventing self-antagonism at high concentrations. [less ▲]

Epidémiologie des facteurs de risque cardiovasculaire : dyslipidémies et hypertension artérielle.

Conference (1994, December 03)

GUESS, un logiciel pour s'entraîner à l'auto-estimation de sa compétence cognitive

in Weber, Jacques (Ed.) QCM et questionnaires fermés, actes du 3ème colloque international ESIEE, Marne-la-Vallée (1994, December)

Carte géologique de Wallonie échelle 1/25.000, Philippeville - Rosée 53/5-6

Cartographic material (1994)

Further results on the line-profile variability of WR 134

in Astrophysics & Space Science (1994, November 01), 221

We discuss a few conclusions previously derived from the analysis of the line-profile variability of the Wolf-Rayet star WR 134, some details are made more explicit. In addition, we present a new set of ... [more ▼]

We discuss a few conclusions previously derived from the analysis of the line-profile variability of the Wolf-Rayet star WR 134, some details are made more explicit. In addition, we present a new set of data and briefly comment on recent results deduced from its analysis. [less ▲]

L'épilepsie de Vincent VAN GOGH

in Cahiers du CEP (Centre d'Etudes Pathoanalytiques) (1994), 4(4), 3-10

Though he never had typical "grand mal" crisis, Vincent VAN GOGH was really epileptic. The symptomatology of epileptic seizures was better known in the XIXd Century than today.

Prévision analytique des défauts d'usinage en chariotage

Report (1994)

This report presents an analytical approach leading to a prediction of the form errors arising when turning a bar, in the three classical fixture configurations. This study consists in determing the ... [more ▼]

This report presents an analytical approach leading to a prediction of the form errors arising when turning a bar, in the three classical fixture configurations. This study consists in determing the radial displacement at the tool end, due to the cutting forces. This displacement, will be retreived with the opposite sign, as a diameter error. Traditional analyses only consider the passive component of the cutting force. Here, the effect of the feed force is also considered. [less ▲]

Phytotechnie du seigle hybride

in Effet des systèmes de culture sur le rendement, la qualité des produits agricoles, la rentabilité et la protection de l'environnement pour les principales cultures et les pâturages (1994, October 10)

A dusty nebula around the luminous blue variable candidate HD 168625

in Astronomy and Astrophysics (1994), 290

On the basis of narrow-band visible and near-infrared imagery as well as high-resolution spectroscopy, we report the discovery of a new LBV-type nebula around the B supergiant HD 168625. We find that it ... [more ▼]

On the basis of narrow-band visible and near-infrared imagery as well as high-resolution spectroscopy, we report the discovery of a new LBV-type nebula around the B supergiant HD 168625. We find that it essentially consists of a dusty expanding shell from which seems to emerge a bipolar emission nebula, the whole embedded in a reflection nebulosity. The inner shell is stratified: the continuum emission arises beyond the ionized gas, and is possibly due to scattering of stellar light by large dust grains or to non-equilibrium dust emission. The unexpected presence of unidentified infrared emission bands (UIRs) in the spectrum of this object is also discussed. We finally report the non-detection of a comparable nebula around the nearby LBV HD 168607. [less ▲]