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See detailValine-based biphenylsulphonamide matrix metalloproteinase inhibitors as tumor imaging agents
Oltenfreiter, R.; Staelens, L.; Kersemans, V. et al

in Applied Radiation & Isotopes (2006), 64(6), 677-685

Among matrix metalloproteinases (MMPs), the subfamily of gelatinases (MMP-2, MMP-9) is of particular interest due to their ability to degrade type IV collagen and other non-fibrillar collagen domains and ... [more ▼]

Among matrix metalloproteinases (MMPs), the subfamily of gelatinases (MMP-2, MMP-9) is of particular interest due to their ability to degrade type IV collagen and other non-fibrillar collagen domains and proteins such as fibronectin and laminin. Whilst malignant cells often over-express various MMPs, the gelatinases have been most consistently detected in malignant tissues and associated with tumor growth, metastatic potential and angiogenesis. Radiosynthesis of carboxylic (1') and hydroxamic (2') MMPIs resulted in radiochemical yields of 70 +/- 5% (n = 6) and 60 5% (n = 4), respectively. Evaluation in A549-inoculated athymic mice showed a tumor uptake of 2.0 +/- 0.7%ID/g (3 h p.i.), a tumor/blood ratio of 0.5 and a tumor/muscle ratio of 4.6 at 48 h p.i. for 1'. For compound 2' a tumor uptake of 0.7 +/- 0.2%ID/g (3 h p.i.), a tumor/blood ratio of 1.2 and a tumor/muscle ratio of 1.8 at 24 h p.i. were observed. HPLC analysis of the blood (plasma) showed no dehalogenation or other metabolites of 1' 2 h p.i. For compound 2', 65.4% of intact compound was found in the blood (plasma) and one polar metabolite (31%) was detected whereas in the tumor 91.8% of the accumulated activity was caused by intact compound and only 8.1% by the metabolite. Planar imaging, using a Toshiba GCA-9300A/hg SPECT camera, showed that tumor tissue could be visualized and that image quality improved by decreasing specific activity resulting in lower liver uptake, indicating some degree of saturable binding in the liver. In vivo evaluation of these radioiodinated carboxylic and hydroxamic MMP inhibitor tracers revealed that MMP inhibitors could have potential as tumor imaging agents, but that further research is necessary. (c) 2006 Elsevier Ltd. All rights reserved. [less ▲]

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See detailA stability diagram computation method for milling adapted to automotive industry
Le Lan, Jean-Vincent; Marty, Audrey; Debongnie, Jean-François ULg

Conference (2006, June)

In this paper, a numerical method to compute stability diagrams is presentd. It is adapted to the particular case of automotive parts production where chatter arises due to the lack of stiffness of the ... [more ▼]

In this paper, a numerical method to compute stability diagrams is presentd. It is adapted to the particular case of automotive parts production where chatter arises due to the lack of stiffness of the workpiece. The main features of the model are the simultaneous immersion of many teeth, frequency domain computations and the use of the Finite Element Method to provide transfer function. [less ▲]

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See detailImpact of laser-assisted hatching on pregnancy rate in fresh and frozen-thawed cycles
Thonon, Fabienne ULg; Gaspard, Olivier ULg; Jouan, Caroline ULg et al

in Human Reproduction (2006, June), 21(Suppl. 1), 124

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See detailTrophic diversity and potential role of detritivorous crustaceans in Posidonia oceanica litter
Sturaro, Nicolas ULg; Gobert, Sylvie ULg; Cox, Anne-Sophie et al

Conference (2006, June)

Detrivorous crustaceans are pivotal components of the trophic food webs and are found to be the main constituents of the macrofauna in Posidonia oceanica litter. The coexistence of many of these species ... [more ▼]

Detrivorous crustaceans are pivotal components of the trophic food webs and are found to be the main constituents of the macrofauna in Posidonia oceanica litter. The coexistence of many of these species in the same biotope raises the question of trophic diversity and of its role in litter degradation process. Diet composition of five common species of detrivorous crustaceans in P. oceanica litter (i.e. the gammarid amphipods Gammarella fusicola and Gammarus aequicauda and the isopods Idotea baltica, Idotea hectica and Zenobiana prismatica) were studied using a combination of gut content and stable isotopes analysis. Despite the common food supply (i.e. Posidonia dead leaf, Posidonia epiphytes or drift macroalgae), there were considerable interspecific differences in diet composition. Gut content observations indicate that P. oceanica leaf litter is an important part of the ingested food of all the species. Algae material (macroepiphytes and drift macroalgae) inhabiting the litter is mainly found in G. fusicola, I. hectica and I. baltica. I. baltica displays a high proportion of crustacean fragments. Isotope ratios showed that most of the species do not assimilate much of the ingested Posidonia. Application of a mixing model using isotopic values to estimate the contribution of the potential different food sources confirms this view. On one hand, the tissue of G. aequicauda could be constituted by more than 50 % of P. oceanica carbon. On the other hand, for the other species studied, P. oceanica represented a minor contribution (10 - 30 %), although it is a major component of the gut contents. This could imply that micro-organism (diatoms, bacteria and fungi) living on the Posidonia detritus is a major food source of detrivorous. Moreover, I. baltica, Z. prismatica and G. fusicola have a diversified diet composed mainly of algae. Crustaceans are an important food source for I. baltica. By contrast, I. hectica indicated a major contribution of algae material. Our results demonstrate the trophic diversity existing between the detrivorous crustaceans species in P. oceanica litter. This trophic diversity is probably one of the factors that allows these species to coexist in the same biotope. The results also underline the potential role of these species in the degradation of P. oceanica litter by fragmenting mechanically the Posidonia detritus and by assimilating directly Posidonia carbon and transferring it to higher trophic level (i.e. coastal fishes). Moreover, it allows us to think that micro-organisms (diatoms, bacteria and fungi) colonising leaf litter may constitute an important food source for litter fauna. [less ▲]

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See detailCOSMOGRAIL: the COSmological MOnitoring of GRAvItational Lenses - III. Redshift of the lensing galaxy in eight gravitationally lensed quasars
Eigenbrod, A.; Courbin, F.; Meylan, G. et al

in Astronomy and Astrophysics (2006), 451(3), 759-766

Aims. We measure the redshift of the lensing galaxy in eight gravitationally lensed quasars in view of determining the Hubble parameter H-0 from the time delay method. Methods. Deep VLT/FORS1 spectra of ... [more ▼]

Aims. We measure the redshift of the lensing galaxy in eight gravitationally lensed quasars in view of determining the Hubble parameter H-0 from the time delay method. Methods. Deep VLT/FORS1 spectra of lensed quasars are spatially deconvolved in order to separate the spectrum of the lensing galaxies from the glare of the much brighter quasar images. A new observing strategy is devised. It involves observations in Multi-Object-Spectroscopy (MOS) which allows the simultaneous observation of the target and of several PSF and flux calibration stars. The advantage of this method over traditional long-slit observations is a much more reliable extraction and flux calibration of the spectra. Results. For the first time we measure the redshift of the lensing galaxy in three multiply-imaged quasars: SDSS J1138+0314 (zlens = 0.445), SDSS J1226-0006 (z(lens) = 0.517), SDSS J1335+0118 (z(lens) = 0.440), and we give a tentative estimate of the redshift of the lensing galaxy in Q 1355- 2257 (z(lens) = 0.701). We confirm four previously measured redshifts: HE 0047-1756 (z(lens) = 0.407), HE 0230-2130 (z(lens) = 0.523), HE 0435-1223 (z(lens) = 0.454) and WFI J2033-4723 (z(lens) = 0.661). In addition, we determine the redshift of the second lensing galaxy in HE 0230-2130 (z(lens) = 0.526). The spectra of all lens galaxies are typical for early-type galaxies, except for the second lensing galaxy in HE 0230-2130 which displays prominent [OII] emission. [less ▲]

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See detailObésité: aube hésitée, et quoi pour moi demain
Battisti, Oreste ULg

Conference (2006, June)

cette journée aborde le cocnept familial, l'aspect communautaire, l'épidémiologie, l'aspect nutritionnel, l'aspect somatique et l'aspect psychologique de l'obésité de l'enfant dans le cadre familial.

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See detailPrediction of the acoustics of coupled rooms with the acoustic-diffusion model
Valeau, Vincent; Billon, Alexis ULg; Hodgson, Murray et al

Conference (2006, June)

A general model is proposed to simulate the acoustics of coupled rooms. It is based on a diffusion equation, solved numerically to perform acoustic predictions. The presence of scattering objects –or the ... [more ▼]

A general model is proposed to simulate the acoustics of coupled rooms. It is based on a diffusion equation, solved numerically to perform acoustic predictions. The presence of scattering objects –or the “fittings”– is also taken into account. Distinct sub-volumes can be defined, representing either coupled volumes or zones with different fitting characteristics. Some sample results are presented, and compared with ray-tracing results and experimental data. Two situations are assessed: two coupled classrooms, and a room divided into two zones, one empty, one fitted. The diffusion-model predictions match the other data satisfactorily, both in terms of sound attenuation and sound decay. Diffusion-based results are obtained with the advantage of low computational time compared to ray-tracing results. [less ▲]

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See detailCompression of the Earth's magnetotail by interplanetary shocks directly drives transient magnetic flux closure
Hubert, Benoît ULg; Palmroth, Minna; Laitinen, Tiera V. et al

in Geophysical Research Letters (2006), 33(10),

We use a novel method to evaluate the global opening and closure of magnetic flux in the terrestrial system, and to analyse two interplanetary shock passages that occurred during magnetically quiet ... [more ▼]

We use a novel method to evaluate the global opening and closure of magnetic flux in the terrestrial system, and to analyse two interplanetary shock passages that occurred during magnetically quiet periods. We find that, even under these quiet conditions, where the amount of open flux was already low, the compression of the magnetotail by the shocks still created intense but short-lived bursts of flux closure reaching similar to 130 kV, comparable to values obtained shortly after a substorm onset, although no expansion phase developed. The results, supported by a global MHD simulation of the space environment, point to a trigger mechanism of flux closure directly driven by the solar wind compression, independent of the usual substorm expansion phase process. [less ▲]

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See detailMutualité « all inclusive »
Balthasar, Jean-Pierre; Collignon, Fabrice; Collin, Pierre et al

Article for general public (2006)

Promo, carte de fidélité... Les mutuelles s'inscrivent de plus en plus dans une logique de concurrence commerciale sur des aspects qui s'éloignent de la santé. Dans la vie de tous les jours, elle vous ... [more ▼]

Promo, carte de fidélité... Les mutuelles s'inscrivent de plus en plus dans une logique de concurrence commerciale sur des aspects qui s'éloignent de la santé. Dans la vie de tous les jours, elle vous accompagne. Une angine, un accouchement, une jambe cassée aux sports d'hiver, une invalidité, elle vous soulage et vous protège. C'est votre mutuelle. Récemment la nôtre nous a proposé de remplir un questionnaire relatif à ses produits et services complémentaires. Celui-ci répertorie une série d'offres potentielles que le mutualisé standard doit évaluer sur une échelle variant de 1 (aucune importance) à 10 (extrêmement important). Nous nous sommes prêtés à cet exercice. Après les questions relatives à l'objet même d'une mutualité, à savoir les soins de santé, notre opinion est sollicitée par rapport au concept de «carte de fidélité» qui proposerait des avantages (promotions, réductions, remises) sur des produits concernant notre santé et notre bien-être. [...] [less ▲]

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See detailAgricultural tools guidance assistance by using machine vision
Leemans, Vincent ULg; Destain, Marie-France ULg

in Proceedings of the NCTAM 2006 7th National Congress on Theoretical and Applied Mechanics (2006, May 30)

This paper presents a regulation mechanism aiming to position agricultural tools relatively to the previous lines, while sowing or harvesting. The sowing rows were revealed by a background correction, the ... [more ▼]

This paper presents a regulation mechanism aiming to position agricultural tools relatively to the previous lines, while sowing or harvesting. The sowing rows were revealed by a background correction, the background being obtained thanks to a median rank filter. The method was found efficient in eliminating the shadows. For the crop rows (chicory rows), a neural network was used to localise the plants. While the petiole and the leaves were easily separated from the soil, the chicory root and the soil having about the same colour and the lighting condition varying widely, it was more difficult to obtain a good contrast between those parts, which leaves place for some improvements. The adapted Hough transform consisted in computing one transform for each line in the cluster with, for reference, the position and direction of the theoretical position of the row. The different transforms were then added. The position was used in a feedback regulation loop. An articulated mechanism was used to ensure the lateral displacement of the tool relatively to the tractor. The behaviour of the whole outfit was studied during several field tests. The standard deviation of the error, measured as the difference between the observed inter-row distance and its theoretica value, was of 23 mm for sowing and 31 mm for harvesting and its amplitude was less than 100 mm for sowing and less than 115 mm during the harvest, which was sufficient to fulfil the requirements of the application. Sources of systematic errors were also identified as linked to the geometric considerations. Their correction requires an accurate mounting of the camera, which may be possible for a serial montage. [less ▲]

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See detailSlip rate and mode of the Feldbiss normal fault (Roer Valley Graben) after removal of groundwater effects
Demoulin, Alain ULg

in Earth and Planetary Science Letters (2006), 245(3-4), 630-641

The Feldbiss fault is the main active fault bounding to the southwest the Roer Valley Graben of NW Europe. In order to investigate the reasons of the discrepancy between its short- and long-term slip rate ... [more ▼]

The Feldbiss fault is the main active fault bounding to the southwest the Roer Valley Graben of NW Europe. In order to investigate the reasons of the discrepancy between its short- and long-term slip rate estimates, we have repeatedly surveyed a 2.3 km-long line by levelling at Sittard (The Netherlands) from April 2001 to December 2004. Simultaneously, three superposed aquifers were monitored on both sides of the fault. The across-fault differential groundwater variations are shown to be responsible for a seasonal 0.87 mm/m vertical motion of the fault, mainly through the effect of pore pressure changes in confined aquifers. After removal of this effect, I get a residual trend of -0.60 +/- 0.11 mm/yr for the relative motion of the hangingwall. This trend was disturbed in the summer of 2002 by transient millimetre-level up and down motions temporally associated with the small Eschweiler earthquake that occurred on July 22, 2002 on the Feldbiss fault at a distance of 35 km from Sittard. I explain this as a creep event triggered by the passage of trapped seismic waves. The subsisting discrepancy between the long-term slip rate of 0.06 mm/yr and short-term rates of similar to 1.5 mm/yr (from 1962 to 2001) and 0.6 mm/yr (from 2001 to 2004) is tentatively interpreted as resulting from the current occurrence of a decade-long episode of aseismic slip involving a large part of the fault plane. Occasionally associated with minor seismicity, this aseismic slip event could betray a thickening of the transitional region located below the upper crustal zone of stable sliding. It causes a total fault slip of 5-10 cm in a few tens of years, releasing smoothly all, or a great part of, the strain accumulated during the previous 1-2 ky of fault quiescence. (c) 2006 Elsevier B.V. All rights reserved. [less ▲]

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See detailThe inner debris disk of Vega as seen by CHARA/FLUOR
Absil, Olivier ULg

Scientific conference (2006, May 25)

Using the FLUOR beam-combiner installed at the CHARA Array (Mt Wilson, CA), we have obtained high-precision visibility measurements of Vega, one of the prototypic debris-disk stars, known to be surrounded ... [more ▼]

Using the FLUOR beam-combiner installed at the CHARA Array (Mt Wilson, CA), we have obtained high-precision visibility measurements of Vega, one of the prototypic debris-disk stars, known to be surrounded by a large amount of cold dust in a ring-like structure at 80-100 AU. The combination of short and long baselines has allowed us to separately resolve the stellar photosphere and the close environment of the star (<8 AU). Our observations show a significant deficit in square visibility at short baselines with respect to the expected visibility of a simple UD stellar model (dV2 ~ 2%), suggesting the presence of an extended source of emission around Vega. The sparse (u,v) plane coverage does not allow the discrimination between a point source and an extended circumstellar emission as the source of the extended emission. However, we show that the presence of a point-like source within the FLUOR field-of-view (1" in radius, i.e., 7.8 AU at the distance of Vega) is highly unlikely. The excess emission is most likely due to the presence of hot circumstellar dust in the inner part of Vega's debris disk, with a flux ratio of 1.29 +/- 0.19% between the integrated dust emission and the stellar photosphere. Complementing this result with archival photometric data in the near- and mid-infrared and taking into account a realistic photospheric model for the rapidly rotating Vega, we derive the expected physical properties of the circumstellar dust by modelling its Spectral Energy Distribution. The inferred properties suggest that the Vega system could be currently undergoing major dynamical perturbations. [less ▲]

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See detailLe néo-corporatisme réinterpellé : analyse comparée de deux politiques d'accès à l'emploi, l'apprentissage industriel en Belgique et le contrat de qualification "jeunes" en France
Levêque, Audrey ULg

Doctoral thesis (2006)

L'étude comparative de l'apprentissage industriel en Belgique francophone et du contrat de qualification "jeunes" en France permet de réinterpeller le modèle néo-corporatiste d'Etat social. L'analyse de l ... [more ▼]

L'étude comparative de l'apprentissage industriel en Belgique francophone et du contrat de qualification "jeunes" en France permet de réinterpeller le modèle néo-corporatiste d'Etat social. L'analyse de l'émergence et de la mise en oeuvre de ces deux politiques publiques d'accès à l'emploi pour les jeunes peu qualifiés permet de comprendre comment elles sont réappropriées par les acteurs de terrain et ce, plus particulièrement dans la branche de la métallurgie. Si ces politiques s'adressent théoriquement à ces jeunes peu qualifiés, la mise en oeuvre fait apparaître les employeurs au centre des deux dispositifs. Une logique de recrutement se substitue ainsi à une logique de formation. Si deux régulations particulières émergent, le rôle des partenaires sociaux, véritables activateurs de ces politiques, est primordial dans les deux cas. Acteurs clés du modèle néo corporatiste, ce dernier se voit réinterpellé à la lueur de cette recherche. [less ▲]

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See detailVega: the star with comets?
Absil, Olivier ULg

Scientific conference (2006, May 19)

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