Publications ORBi OA
Bookmark and Share    
Full Text
Peer Reviewed
See detailThe natural history, including orofacial features of three patients with Ehlers-Danlos syndrome, dermatosparaxis type (EDS type VIIC).
Malfait, Fransiska; De Coster, Peter; Hausser, Ingrid et al

in American Journal of Medical Genetics. Part A (2004), 131(1), 18-28

Ehlers-Danlos syndrome (EDS) dermatosparaxis type (type VIIC) and the related disease of cattle dermatosparaxis, are recessively inherited connective tissue disorders, caused by a deficient activity of ... [more ▼]

Ehlers-Danlos syndrome (EDS) dermatosparaxis type (type VIIC) and the related disease of cattle dermatosparaxis, are recessively inherited connective tissue disorders, caused by a deficient activity of procollagen I N-proteinase, the enzyme that excises the N-terminal propeptide in procollagen type I, type II, and type III. Although well documented in cattle, to date only seven human cases have been recorded, most of them aged under 2 years. We document the natural history of three patients with EDS dermatosparaxis type, two of whom have been reported before the age of 2 years, and one new patient. The phenotype of the patients, and especially the facial resemblance, is striking, making this a clinically recognizable condition. The most consistent anomalies during the first years of life are premature rupture of the membranes, extreme skin fragility and easy bruising, large fontanels, blue sclerae, puffy eyelids, micrognathia, umbilical hernia, and short fingers. Joint hypermobility becomes more important with age. The children are at risk for rupture of internal organs due to soft tissue fragility, as is illustrated by different internal events in two of the three patients described here. Orofacial features include micrognathia, a frontal open bite, and gingival hyperplasia with varying degrees of hyperkeratosis. The deciduous dentition shows abnormal morphology of the molars, obliteration of the tooth pulp, and severe enamel attrition. The permanent dentition shows agenesis and microdontia of several teeth. Tooth discoloration, dysplastic roots, and tooth pulp obliteration are present in a restricted number of permanent teeth. [less ▲]

Detailed reference viewed: 17 (1 ULg)
Full Text
Peer Reviewed
See detailEnvironmental dichlorodiphenyltrichlorethane or hexachlorobenzene exposure and breast cancer: is there a risk?
Charlier, Corinne ULg; Foidart, Jean-Michel ULg; Pitance, François ULg et al

in Clinical Chemistry & Laboratory Medicine (2004), 42(2), 222-227

The carcinogenic potential of environmental xenoestrogens (i.e., organochlorines) is a matter of controversy. Their pathogenic role as promoters in breast cancer has been previously suggested. In Europe ... [more ▼]

The carcinogenic potential of environmental xenoestrogens (i.e., organochlorines) is a matter of controversy. Their pathogenic role as promoters in breast cancer has been previously suggested. In Europe, despite their prohibition since the '70s, residues persist in soil and rivers resulting in a widespread contamination of the general population. In this study, we have compared the serum levels of p,p'-1,1-dichloro-2, 2-bis (4-chlorophenyl) ethylene (DDE) and hexachlorobenzene (HCB) in 231 women at the time of breast cancer discovery and in 290 agematched healthy controls. p,p'-DDE was found in 76.2% of cases and in 71.1% of controls but HCB was present only in 12.6% of cases (29 from 231) and in 8.9% of controls (26 from 290). Even if taking all undetectable results (recorded as "0") into consideration, mean values were significantly different in cases when compared to controls. The serum level of p,p'-DDE was 3.46+/-3.48 ppb (0.58+/-0.58 mug/g lipid) in patients and 1.85+/-2.09 ppb (0.31+/-0.35 mug/g lipid) in controls (p<0.0001). The HCB serum level was 0.66+/-1.25 ppb (0.11+/-0.21 mug/g lipid) in patients and 0.20+/-1.02 ppb (0.03+/-0.17 mug/g lipid) in controls (p<0.0001). When considering p,p'-DDE and HCB as binary variables (1 if higher than the limit of quantification, 0 if lower), the presence of both residues was significantly associated with an increased risk of breast cancer development (OR 2.21, 95% CI 1.41-3.48 for p,p'-DDE and OR 4.99, 95% CI 2.95-8.43 for HCB). No excess was observed among parous women or when familial history of breast cancer was considered. In the cancer group, no differences in serum levels of p,p'-DDE or HCB were found in relation with estrogenreceptor (ER) status, Bloom stage or lymph node metastasis, but the HCB level was moderately correlated with tumor size (p=0.026). [less ▲]

Detailed reference viewed: 44 (11 ULg)
Full Text
Peer Reviewed
See detailL'adhésion amélo-dentinaire: Principes et état actuels des connaissances.
Gueders, Audrey ULg; Geerts, Sabine ULg

in Actualités Dentaires de l'université de Liège (2004), 34

La stratégie d'adhésion varie en fonction du type d'adhésif utilisé. Cet article décrit les différents systèmes adhésifs disponibles

Detailed reference viewed: 29 (2 ULg)
Full Text
Peer Reviewed
See detailL'adhésion amélo-dentinaire: Principes et état actuels des connaissances
Gueders, Audrey ULg; Geerts, Sabine ULg

in Actualités Dentaires de l'Université de Liège (2004), 34

Cet article passe en revue les procédures d'adhésion amélo-dentinaire et tente de rationnaliser la classification des différents systèmes adhésifs actuellement disponibles sur le marché.

Detailed reference viewed: 72 (4 ULg)
Full Text
See detailMultivariate discrimination of sands using elongation and abrasivity indices
Pirard, Eric ULg; Vergara, Nicolas

in Proceedings PARTEC (9th European Symposium on Particle Characterization) (2004)

Detailed reference viewed: 13 (1 ULg)
Full Text
Peer Reviewed
See detailGeochemical and Pb isotopic investigations in peat bogs from Southern Chile: Identification of particles supplies and possible paleoclimate record
De Vleeschouwer, François ULg; Ibanez, M.; Mattielli, N. et al

in Geochimica et Cosmochimica Acta (2004), 68(11), 478-478

Detailed reference viewed: 21 (4 ULg)
Full Text
Peer Reviewed
See detailNumerical determination of 3D temperature fields in steel joints
Franssen, Jean-Marc ULg

in Fire & Materials (2004), 28(2-4, MAR-AUG), 63-82

A numerical study was undertaken to investigate the temperature field in steel joints and to compare the temperatures in the joints with the temperatures of the adjacent steel members on the hypothesis ... [more ▼]

A numerical study was undertaken to investigate the temperature field in steel joints and to compare the temperatures in the joints with the temperatures of the adjacent steel members on the hypothesis that the thermal protection is the same on the joint and in the members. Very brief information is given on the numerical model, supplemented with parametric studies made in order to determine the required level of discretization in the time and in the space domain. A simplified assumption for representing the thermal insulation is also discussed and validated. Different numerical analyses are performed, with a variation of the following parameters: (i) type of joints, from very simple to more complex configurations, with welds and/or bolts, all of them representing joints between elements located in the same plane; (ii) unprotected joints or protected by one sprayed material; (iii) ISO, hydrocarbon or one natural fire scenario. The fact that the thermal attack from the fire might be less severe because the joints are usually located in the corner of the compartment is not taken into account. Copyright (C) 2004 John Wiley Sons, Ltd. [less ▲]

Detailed reference viewed: 33 (6 ULg)
Full Text
Peer Reviewed
See detailSalmonella spp. in food of animal origin: a continuous threat for public health?
Korsak Koulagenko, Nicolas ULg; Clinquart, Antoine ULg; Daube, Georges ULg

in Annales de Médecine Vétérinaire (2004), 148(4), 174-193

Salmonella is a mesophilic bacterium that share common characteristics with Enterobacteriaceae. Two species are described: Salmonella enterica and Salmonella bongori. Beside the fact that the infection in ... [more ▼]

Salmonella is a mesophilic bacterium that share common characteristics with Enterobacteriaceae. Two species are described: Salmonella enterica and Salmonella bongori. Beside the fact that the infection in host cells requires type III secretion-systems, little is known, at present, about virulence mechanisms. Among the cultural detection methods, the use of semi-solid media seems more efficient than the others for Salmonella recovery. The techniques based on genetic amplification may be useful in order to further characterize the isolated strains. Salmonella can be isolated from the intestine of numerous animal species and its survival in the surroundings may be quite long. Several serotypes may cause clinical salmonellosis while others may be responsible for animal species of a carrier state. In this abstract, the influence of swine production system will be developed. The sustainable and ongoing surveillance are justified by the fact that Salmonella leads to numerous foodborne cases and outbreaks and is responsible of important economic and social costs. This surveillance aims to improve the sanitary quality of food from "farm to fork". The preventive methods available for the pre-harvest production step and for the slaughterhouse will be also evoked. [less ▲]

Detailed reference viewed: 134 (11 ULg)
Full Text
Peer Reviewed
See detailCase studies in measurement of random incidence scattering coefficients
Vorländer, Michael; Embrechts, Jean-Jacques ULg; De Geetere, Lieven et al

in Acta Acustica United With Acustica (2004), 90(5, SEP-OCT), 858-867

In this work measurements of random-incidence scattering coefficients in three laboratories are compared. The sample geometry is sinusoidal. These surfaces are geometrically identical, but they were ... [more ▼]

In this work measurements of random-incidence scattering coefficients in three laboratories are compared. The sample geometry is sinusoidal. These surfaces are geometrically identical, but they were constructed in different scales. So far, measurements of this kind were performed only in scale models. Using turntables in real sample size was hardly considered possible. One result of general importance is that measurements are indeed possible in real-scale reverberation rooms with turntables of 3 m diameter. There are only small differences between the real-scale and model-scale results. Some variations of the standard procedure were tested and the uncertainties identified: mounting of the sample, connection or sealing between sample and base plate, way of rotating the sample, air absorption and time variances. The results presented can be regarded as guidelines for application of ISO/DIS 17497-1. [less ▲]

Detailed reference viewed: 43 (4 ULg)
Full Text
Peer Reviewed
See detailParamagnetic reentrance of ac screening: Evidence of vortex avalanches in Pb thin films
Silhanek, Alejandro ULg; Raedts, S.; Moshchalkov, V. V.

in Physical Review. B : Condensed Matter (2004), 70(14),

We have studied the influence of a square array of pinning centers on the dynamics of vortex avalanches in Pb thin films by means of ac- and dc-magnetization measurements. Close to the superconducting ... [more ▼]

We have studied the influence of a square array of pinning centers on the dynamics of vortex avalanches in Pb thin films by means of ac- and dc-magnetization measurements. Close to the superconducting transition T-c, the commensurability between the vortex lattice and the pinning array leads to the well known local increments of the critical current. As temperature T decreases, matching features progressively fade out and eventually disappear. Further down in temperature, vortex avalanches develop and dominate the magnetic response. These avalanches manifest themselves as jumps in the dc magnetization and produce a lower ac shielding, giving rise to a paramagnetic reentrance in the ac screening chi(')(T). Within the flux-jump regime, two subregimes can be identified. Close to the boundary where vortex avalanches develop, the field separation between consecutive jumps follows the periodicity of the pinning array and a field- and temperature-dependent screening is observed. In this regime, the response also depends on frequency f in agreement with theoretical models for magnetothermal instabilities. At low enough temperatures and fields, the screening saturates to a constant value independent of T, H, and f, where jumps are randomly distributed. We have also found that vortex instabilities occupy a larger portion of the H-T diagram in patterned samples than in films without nanoengineered pinning sites. Finally, we discuss the possible origin of the vortex avalanches and compare our results with previous experimental and theoretical studies. [less ▲]

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailA Real-Time Grading Method Of Apples Based On Features Extracted From Defects
Leemans, Vincent ULg; Destain, Marie-France ULg

in Journal of Food Engineering (2004), 61(1),

This paper presents a hierarchical grading method applied to Jonagold apples. Several images covering the whole surface of the fruits were acquired thanks to a prototype grading machine. These images were ... [more ▼]

This paper presents a hierarchical grading method applied to Jonagold apples. Several images covering the whole surface of the fruits were acquired thanks to a prototype grading machine. These images were then segmented and the features of the defects were extracted. During a learning procedure, the objects were classified into clusters by k-mean clustering. The classification probabilities of the objects were summarised and on this basis the fruits were graded using quadratic discriminant analysis. The fruits were correctly graded with a rate of 73 %. The errors were found having origins in the segmentation of the defects or for a particular wound, in a confusion with the calyx end. [less ▲]

Detailed reference viewed: 49 (1 ULg)
Full Text
Peer Reviewed
See detailAntagonistic activity of yeast against post-harvest diseases of tropical fruits.
Jijakli, Haissam ULg; Lassois, Ludivine ULg; Lahlali, R.

in Bulletin des Séances de l’Académie Royale des Sciences d’Outre-Mer = Mededelingen der Zittingen van de Koninklijke Academie voor Overzeese Wetenschappen (2004), 50(2), 153-163

Detailed reference viewed: 47 (14 ULg)
Full Text
Peer Reviewed
See detailDevelopment of RT-PCR assays using fluorogenic-3 minor groove binder DNA probes for detection of fruit tree viruses.
Roussel, S.; Kummert, J.; Dutrecq, O. et al

in Acta Horticulturae (2004), 657(1),

Detailed reference viewed: 11 (0 ULg)
Full Text
Peer Reviewed
See detailInhibitory Action Of A New Lectin From Xerocomus Chrysenteron On Cell-Substrate Adhesion
Marty-Detraves, C.; Francis, Frédéric ULg; Baricault, L. et al

in Molecular and Cellular Biochemistry (2004), 258(1-2), 49-55

Detailed reference viewed: 18 (1 ULg)
Full Text
Peer Reviewed
See detailSampling protocols and risk of error significance in molecular detection tests for fruit trees certification.
Kummert, Jean; Malice, Marie ULg; Marbot, Sophie et al

in Acta Horticulturae (2004), (657), 541-546

Detailed reference viewed: 20 (0 ULg)
Full Text
Peer Reviewed
See detailSubtype Selective Substrates For Histone Deacetylases
Heltweg, B.; Dequiedt, Franck ULg; Marshall, Bl. et al

in Journal of Medicinal Chemistry (2004), 47(21),

To probe the steric requirements for deacylation, we synthesized lysine-derived small molecule substrates and examined structure-reactivity relationships with various histone deacetylases. Rat liver ... [more ▼]

To probe the steric requirements for deacylation, we synthesized lysine-derived small molecule substrates and examined structure-reactivity relationships with various histone deacetylases. Rat liver, human HeLa, and human recombinant class I and II histone deacetylases (HDACs) as well as human recombinant NAD(+)-dependent SIRT1 (class III enzyme) were used in these studies. A benzyloxycarbonyl substituent on the alpha-amino group yielded the highest conversion rates. Replacing the epsilon-acetyl group with larger lipophilic acyl substituents led to a pronounced decrease in conversion by class I and II enzymes; the class III enzyme displayed a greater tolerance. Incubations with recombinant FLAG-tagged human HDACs 1, 3, and 6 showed a distinct subtype selectivity among small molecule substrates. The subtype selectivity of HDAC inhibitors could be predicted with these substrates and an easily obtainable mixture of HDAC subtypes. [less ▲]

Detailed reference viewed: 20 (6 ULg)
Full Text
Peer Reviewed
See detailKinetics of engraftment in patients with hematologic malignancies given allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning.
Baron, Frédéric ULg; Baker, Jennifer E.; Storb, Rainer et al

in Blood (2004), 104(8), 2254-62

We analyzed the kinetics of donor engraftment among various peripheral blood cell subpopulations and their relationship to outcomes among 120 patients with hematologic malignancies given hematopoietic ... [more ▼]

We analyzed the kinetics of donor engraftment among various peripheral blood cell subpopulations and their relationship to outcomes among 120 patients with hematologic malignancies given hematopoietic cell transplantation (HCT) after nonmyeloablative conditioning consisting of 2 Gy total body irradiation (TBI) with or without added fludarabine. While patients rapidly developed high degrees of donor engraftment, most remained mixed donor/host chimeras for up to 180 days after HCT. Patients given preceding chemotherapies and those given granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cell (G-PBMC) grafts had the highest degrees of donor chimerism. Low donor T-cell (P = .003) and natural killer (NK) cell (P = .004) chimerism levels on day 14 were associated with increased probabilities of graft rejection. High T-cell chimerism on day 28 was associated with an increased probability of acute graft-versus-host disease (GVHD) (P = .02). Of 93 patients with measurable malignant disease at transplantation, 41 achieved complete remissions a median of 199 days after HCT; 19 of the 41 were mixed T-cell chimeras when complete remissions were achieved. Earlier establishment of donor NK-cell chimerism was associated with improved progression-free survival (P = .02). Measuring the levels of peripheral blood cell subset donor chimerisms provided useful information on HCT outcomes and might allow early therapeutic interventions to prevent graft rejection or disease progression. [less ▲]

Detailed reference viewed: 4 (0 ULg)