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See detailEffect of ADAMTS-2, a metalloproteinase containing a disintegrin domain and thrombospondin type I repeats, during angiogenesis in vitro and in vivo
Dubail, Johanne ULg; Kesteloot, Frédéric ULg; Motte, Patrick ULg et al

in Angiogenesis (2004), 7(2), 172

Formation of new blood vessels (angiogenesis) is a key step during the development of various pathologies, including cancer. Enzymes of the ADAMTS family are closely related to MMPs and ADAMs. They ... [more ▼]

Formation of new blood vessels (angiogenesis) is a key step during the development of various pathologies, including cancer. Enzymes of the ADAMTS family are closely related to MMPs and ADAMs. They further contain specific domains, such as the ‘‘Thrombospondin type I’’ (TSP1) repeats, that are able to strongly repress angiogenesis, as described for thrombospondin-1 and -2, and for ADAMTS-1 and -8. The primary function of ADAMTS-2 is to process collagen type I, II and III precursors into mature molecules by excising the aminopropeptide. We further hypothesized that it could modulate angiogenesis through its TSP1 repeats. This hypothesis was investigated using different in vitro experimental models of angiogenesis. Recombinant ADAMTS-2 induced morphological changes in human umbilical vein endothelial cells (HUVEC) and human microvessel endothelial cells (HMEC), and significantly reduced their proliferation, attachment and spreading. Similar effects were observed when using inactive ADAMTS-2 mutated at the Zn2+-binding catalytic site. ADAMTS-2 did not alter the initial steps of formation of capillary-like structures by HUVEC in vitro. However, these structures appeared much less stable and were more rapidly disrupted in presence of ADAMTS-2 than in control conditions. ADAMTS-2 was also tested in an ex vivo angiogenesis model using aortic rings from rats and mice, wild type or KO for ADAMTS-2. Outgrowth of capillaries was slightly increased from aortas of ADAMTS-2 KO mice (TS2-/-) as compared to aortas from control animals (TS2+/+), while addition of full size recombinant ADAMTS-2 reduced the formation of capillary structures from rat aortas, suggesting its anti-angiogenic activity. Choroidal neovascularization induced in TS2+/+ or TS2-/- mice by LASER burns was used as in vivo model to confirm the in vitro and ex vivo results. Several genes involved in the healing and angiogenesis processes (fibrillar collagens, VEGF, TGF-beta and CTGF) were not differently regulated in TS2+/+ and TS2-/- mice at 5 days. [less ▲]

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See detailInvasion and MMP expression profile in desmoid tumours.
Denys, H.; De Wever, O.; Nusgens, Betty ULg et al

in British Journal of Cancer (2004), 90(7), 1443-9

Desmoid tumours are locally invasive soft tissue tumours in which beta-catenin mediated TCF-dependent transcription is activated. The role of soluble factors secreted by the myofibroblastic desmoid tumour ... [more ▼]

Desmoid tumours are locally invasive soft tissue tumours in which beta-catenin mediated TCF-dependent transcription is activated. The role of soluble factors secreted by the myofibroblastic desmoid tumour, which could stimulate tumour invasiveness, was investigated. Using collagen gel invasion assays, the presence of factors stimulating invasion in desmoid conditioned media (CM) could be established. Since matrix metalloproteinases (MMPs) have been implicated in the process of tumoral invasion, the expression levels of the MMP family members were evaluated. Quantitative reverse transcription-PCR was used to determine the expression levels of MMP1, MMP2, MMP3, MMP7, MMP11, MMP12, MMP13, MMP14 and the inhibitors TIMP1, TIMP2 and TIMP3. Besides overexpression of MMP7, a known TCF-dependent target gene, a striking upregulation of the expression levels of MMP1, MMP3, MMP11, MMP12 and MMP13 in desmoid tumours, compared to unaffected fibroblasts from the same patients, was found. Treating the CM of desmoids with a synthetic and a physiologic MMP inhibitor reduced the invasion-stimulating capacity of the desmoid CM by approximately 50%. These results suggest the involvement of soluble factors, released by the desmoid cells, in stimulating invasion and implicate the MMPs as facilitators of invasion. [less ▲]

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See detailCartografia Preliminar de los minerales evaporiticos del salar de Coipasa utilisando imagenes Aster
Caceres, Fernando; Gutierrez, Jorge; Pirard, Eric ULg

in Conferencia Nacional de Valorizacion de los Salares (2004)

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See detailMonitoring color alteration of ornamental flagstones using digital image analysis.
Lebrun, Vincent; Toussaint, Caroline; Pirard, Eric ULg

in Prykryl, R. (Ed.) Dimension Stone (2004)

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See detailLe stockage post-récolte : une étape clé du processus de production.
Delaplace, Pierre ULg; Fauconnier, Marie-Laure ULg

in Troupeaux et Cultures des Tropiques (2004), 4

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See detailWound-healing of the potato (Solanum tuberosum L.) tuber in response to catalase inhibition.
Bajji, M.; Colson, M.; Delaplace, Pierre ULg et al

in Acta Physiologiae Plantarum (2004), 26

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See detailAdult Growth Hormone Deficiency
Beckers, Albert ULg; Beckers, Albert ULg

Textual, factual or bibliographical database (2004)

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See detailThe Genetics of Growth Hormone Axis
Beckers, Albert ULg; Beckers, Albert ULg

Textual, factual or bibliographical database (2004)

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See detailTechnologie du débitage laminaire
Flas, Damien ULg

in Miller, Rebecca; Haesaerts, Paul; Otte, Marcel (Eds.) L’atelier de taille aurignacien de Maisières-Canal (Belgique) (2004)

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See detailCoton biologique et / ou équitable en Afrique de l'Ouest : Etat des Lieux
Kouakou, Guy Eric Anicet Quassy ULg

Master of advanced studies dissertation (2004)

The biological cotton and / or fair highlights an environment-friendly agriculture(farming) and guaranteeing better income to the farmers.

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See detailRadioimmunoassay of bovine placental lactogen (bPL) using an antiserum raised in guinea pigs: measurement in foetal plasma
Alvarez-Oxiley, A. V.; Melo de Sousa, Noelita ULg; Touati, Kamal ULg et al

in Reproduction (Cambridge, England). Abstract Series (2004), 31

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See detailApplication of bioencapsulated proteinases and peptides for wound gealing
Markvicheva, E; Dugina, T; Grandfils, Christian ULg et al

in Chemical Industry (2004), 58(6a), 165-175

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See detailParadoxe: lorsqu'un etat prothrombotique est responsable d'une hemorragie digestive. Observation d'un cas de sclerose hepatoportale
Croes, F.; Servais, B.; Delwaide, Jean ULg et al

in Revue Médicale de Liège (2004), 59(1), 32-34

Variceal bleeding is frequently the initial presentation of a previously unknown cirrhosis. Portal hypertension and its complications without liver cirrhosis should raise the possibility of presinusoidal ... [more ▼]

Variceal bleeding is frequently the initial presentation of a previously unknown cirrhosis. Portal hypertension and its complications without liver cirrhosis should raise the possibility of presinusoidal portal hypertension, and the diagnosis of hepatoportal sclerosis. These patients need to be investigated for coagulation disorders. A hypercoagulable state is often associated. Risks and benefits of anticoagulation should be further investigated in these patients. [less ▲]

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See detailDéveloppement d'un système harmonisé de surveillance de la qualité des terres agricoles en région wallonne anticipant la future directive européenne sur les sols.
Warin, Arnaud; Marcoen, Jean Marie ULg; Bernaerdt, R. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2004), 8(2), 69-82

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See detailVers un outil d'aide à la décision et de planification de l'assainissement autonome en Région wallonne
Frippiat, Céline; Marcoen, Jean Marie ULg; Lejeune, Jean-Luc et al

in La tribune de l'eau (2004), 57

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See detailDes géoindicateurs pour l'analyse et l'évaluation des voies romaines. Etude de la voie romaine Bavay-Tongres.
Gochel, François; Schmitz, Serge ULg; Ozer, André ULg

in Bulletin de la Société Géographique de Liège (2004), 44

The Auteur research geoindicators indicating the presence of a Roman road. A geo-indicator is a localised item that accompanies other item less apprehensible. Eight indicators are discussed (straightness ... [more ▼]

The Auteur research geoindicators indicating the presence of a Roman road. A geo-indicator is a localised item that accompanies other item less apprehensible. Eight indicators are discussed (straightness, elevated road, position on the ridge, administrative border, chapel, parcelling, other roman traces, toponym). These geoindicators permit searching Roman road but also determine the more characteristic sectors. [less ▲]

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See detailRépartition, habitat et conservation des amphibiens du Pays de Herve
Denoël, Mathieu ULg

in Bulletin de la Société Herpétologique de France (2004), 111-112

The knowledge of distribution and ecological determinants of species is a prerequisite to their conservation at a time where declines are generalized at a world scale. The aim of this study is to ... [more ▼]

The knowledge of distribution and ecological determinants of species is a prerequisite to their conservation at a time where declines are generalized at a world scale. The aim of this study is to characterize these topics to discuss the status of amphibian species in Pays de Herve, an area which is representative of hedged farmland regions and their evolution toward a landscape homogenization. On more than four hundreds ponds surveyed, 72% contained amphibians. All Walloon amphibian species (except those recently disappeared), were present but some were rare. The natterjack toad and the crested newt are the two most threatened species in a close future, but almost all species are threatened with large population decreases. The destruction and abandon of cattle ponds is the primary factor of decline of amphibians in Pays de Herve, but other factors such as fish introduction and water pollution have also a negative impact in decreasing biodiversity in favour of less specialized species. Management and conservation measures should be taken as soon as possible to stop or at least slow down the current process. [less ▲]

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See detailTraitement du cancer du sein chez la personne âgée
Gillain, Sophie ULg; Gennigens, Christine ULg; Sautois, Brieuc ULg et al

in Revue Médicale Suisse (2004), 62

Le cancer du sein représente chez la personne âgée une pathologie fréquente. Le choix du traitement dépend de l'âge physiologique, des pathologies et comorbidités associées ainsi que du niveau de vie et d ... [more ▼]

Le cancer du sein représente chez la personne âgée une pathologie fréquente. Le choix du traitement dépend de l'âge physiologique, des pathologies et comorbidités associées ainsi que du niveau de vie et d'autonomie. De plus, selon les facteurs histopronostiques (récepteurs aux oestrogènes et à la progestérone, la surexpression du cerb-B2) on décidera éventuellement du schéma thérapeutique le plus approprié. Chez la personne âgée, la chirurgie (mastectomie ou tumorectomie), la radiothérapie et l'hormonothérapie trouvent leur place. Au-delà de 70 ans, la place de la chimiothérapie est incertaine. En effet, les patientes de plus de 70 ans sont sous-représentées dans les études randomisées. [less ▲]

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See detailCaractérisation pédologique des berges sensibles: problématique de l'accès du bétail aux cours d'eau
Leboeuf, Dimitri; Marcoen, Jean Marie ULg; Bock, Laurent ULg

in Monitoring et gestion physique des cours d'eau wallons. (2004)

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See detailL’accompagnement des personnes handicapées en Belgique : un concept au coeur des nouvelles politiques sociales
Vrancken, Didier ULg

in Nouvelles Pratiques Sociales (2004), 1

Cet article tente de démontrer l’émergence de nouvelles politiques sociales concernant les personnes handicapées en Belgique. Nous nous attarderons sur des pratiques spécifiques appelées « accompagnement ... [more ▼]

Cet article tente de démontrer l’émergence de nouvelles politiques sociales concernant les personnes handicapées en Belgique. Nous nous attarderons sur des pratiques spécifiques appelées « accompagnement de personnes handicapées ». Il vise principalement à démontrer la présence de trois modèles de politiques du handicap. Ces trois modèles sont : le « modèle aliéniste », le « modèle protectionnel » et le « modèle de l’activation ». Nous expliquerons pourquoi le modèle de l’activation est important pour comprendre la redéfinition des politiques sociales de nos jours. [less ▲]

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