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See detailBreast cancer and serum organochlorine residues
Charlier, Corinne ULg; Albert, Adelin ULg; Herman, Philippe ULg et al

in Occupational and Environmental Medicine (2003), 60(5), 348-351

Background: Controversy still exists about the breast carcinogenic properties in humans of environmental xenoestrogens (organochlorines), justifying new investigations. Aims: To compare the blood levels ... [more ▼]

Background: Controversy still exists about the breast carcinogenic properties in humans of environmental xenoestrogens (organochlorines), justifying new investigations. Aims: To compare the blood levels of total dichlorodiphenyltrichloroethane (DDT) and hexachlorobenzene (HCB) in samples collected at the time of breast cancer discovery, in order to avoid the potential consequences of body weight change ( after chemotherapy or radiotherapy) on the pesticide residue levels. Methods: Blood levels of HCB and total DDT (we calculated total DDT concentrations by adding all DDT and DDE isomers) were compared in 159 women with breast cancer and 250 presumably healthy controls. Risk of breast cancer associated with organochlorine concentration was evaluated. Results: Mean levels of total DDT and HCB were significantly higher for breast cancer patients than for controls. No differences in serum levels of total DDT or HCB were found between oestrogen receptor positive and oestrogen receptor negative patients with breast cancer. Conclusions: These results add to the growing evidence that certain persistent pollutants may occur in higher concentrations in blood samples from breast cancer patients than controls. [less ▲]

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See detailLe col circulaire comme articulation flexible
Merken, Patrick; Debongnie, Jean-François ULg

Conference (2003, May)

Nous présentons un modèle permettant de déterminer les dimensions du col, R et ho, en fonction du matériau, de l'angle de rotation désiré et du nombre de cycles envisagé. Dans le cas du col circulaire ... [more ▼]

Nous présentons un modèle permettant de déterminer les dimensions du col, R et ho, en fonction du matériau, de l'angle de rotation désiré et du nombre de cycles envisagé. Dans le cas du col circulaire, les équations de base de la résistance des matériaux appliquées aux poutres à section variable admettent une solution analytique grâce à un changement de variable judicieux inspiré de la théorie de la lubrification. Pour un rapport entre l'épaisseur de col et son rayon tendant vers zéro, nous pouvons également dériver des formes asymptotiques des équations obtenues. Dans le cas de rapports ho/R moyens, ces résultats doivent être affectés de coefficients correcteurs qui dépendent eux-mêmes du rapport ho/R et que l'on détermine à partir des résultats numériques obtenus par la théorie complète. Ainsi, toutes les propriétés du col peuvent déduites grâce aux équations aux limites et à ces coefficients simples. [less ▲]

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See detailNew Solutions to the Problem of Range Dependence in Bistatic STAP Radars
Lapierre, Fabian; Van Droogenbroeck, Marc ULg; Verly, Jacques ULg

in IEEE Radar Conference 2003, Proceedings (2003, May)

We address the problem of detecting slow-moving <br />targets using a space-time adaptive processing (STAP) radar. <br />The construction of optimum weights at each range implies <br />the estimation of ... [more ▼]

We address the problem of detecting slow-moving <br />targets using a space-time adaptive processing (STAP) radar. <br />The construction of optimum weights at each range implies <br />the estimation of the clutter covariance matrix. This is typically <br />done by straight averaging of neighboring data snapshots. <br />However, in bistatic configurations, these snapshots are rangedependent. <br />As a result, straight averaging results in poor performance. <br />After reviewing existing methods for handling the <br />range-dependence, we present new methods exploiting the precise <br />shape of the bistatic direction-Doppler curves. [less ▲]

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See detailInteret et limites du depistage de masse du cancer du sein par mammographie seule (mammotest)
Lifrange, Eric ULg; Bleret, Valerie ULg; Desreux, Joëlle ULg et al

in Revue Médicale de Liège (2003), 58(5), 331-7

The literature on screening mammography provides ample opportunity for doubt (the sceptics) and dogma (the screening zealots), and can be interpreted to prove both benefit and harm. The benefit of ... [more ▼]

The literature on screening mammography provides ample opportunity for doubt (the sceptics) and dogma (the screening zealots), and can be interpreted to prove both benefit and harm. The benefit of mammography screening, if any, is modest and the balance between beneficial (potentially, a 20% relative reduction in breast cancer mortality with no significant benefit on all-cause mortality) and harmful (physical and psychological morbidity related to the 15-40% missed cancers and the 80-90% false-positive diagnoses) effects is still delicate. The mammogram alone is a modest weapon. Concurrent clinical breast examination is mandatory. Women that are concerned about breast cancer should be fully informed of the potential benefits and risks of screening mammography. These women should benefit from mammography with concurrent clinical breast examination, and possible whole-breast ultrasound in heterogeneously dense and extremely dense breast patterns. [less ▲]

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See detailIdentification of elastoplastic model in large deformation problems
Jeunechamps, Pierre-Paul ULg; Walmag, Jérôme ULg; Delhez, Eric ULg et al

in Cinquini, Carlo (Ed.) Proceedings of the 5th World Congress of Structural and Multidisciplinary Optimization WCSMO5 (2003, May)

This paper reports on preliminary results of parameter identification problems in finite element non-linear analyses such as metal forming simulations. Two approaches are compared. The first one is the ... [more ▼]

This paper reports on preliminary results of parameter identification problems in finite element non-linear analyses such as metal forming simulations. Two approaches are compared. The first one is the classic Levenberg-Marquardt algorithm. The second one is a trust-region algorithm based on a quadratic model. The two algorithms are compared on two cases, one of them being an actual experiment. [less ▲]

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See detailL'hypnose en Anesthésie-Réanimation, de l'application clinique aux mécanismes cérébraux
FAYMONVILLE, Marie-Elisabeth ULg

Thèse d’agrégation de l’enseignement supérieur (2003)

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See detail3-Bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo
Kempen, I.; Papapostolou, D.; Thierry, N. et al

in British Journal of Cancer (2003), 88(7), 1111-1118

In search for new anticancer agents, we have evaluated the antiinvasive and antimigrative properties of recently developed synthetic coumarin derivatives among which two compounds revealed important ... [more ▼]

In search for new anticancer agents, we have evaluated the antiinvasive and antimigrative properties of recently developed synthetic coumarin derivatives among which two compounds revealed important activity: 3-chlorophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate and 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate, Both drugs were able to inhibit cell invasion markedly in a Boyden chamber assay, the bromo derivative being more potent than the reference matrix metalloprotease (MMP) inhibitor GI 129471. In vivo, tumour growth was reduced when nude mice grafted with HT 1080 or MDA-MB231 cells were treated i.p. 3 days week(-1) with the bromo coumarin derivative. These effects were not associated with the inhibition of urokinase, plasmin, MMP-2 or MMP-9. The mechanism of action of the drugs remains to be elucidated. However, these two coumarin derivatives may serve as new lead compounds of an original class of antitumour agents. [less ▲]

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See detailQuantification of the Carbonate Pump: Case study of an Emiliania huxleyi bloom in the Bay of Biscay
Harlay, Jérôme ULg; Chou, Lei; Roevros, Nathalie et al

Poster (2003, April 03)

Little attention has been paid until now to the processes controlling the production, dissolution and fate of biogenic calcium carbonate in the oceans. It is however well known that net deposition rates ... [more ▼]

Little attention has been paid until now to the processes controlling the production, dissolution and fate of biogenic calcium carbonate in the oceans. It is however well known that net deposition rates of inorganic carbon to the sediments are comparable to those of organic matter. There remains still large uncertainties in the production and redissolution of biogenic carbonate in the marine system and thus about the role of the carbonate pump in response to anthropogenic CO2 perturbations. The understanding of these processes is also a prerequisite to predict the response of marine organisms to global environmental changes. In the framework of the Belgian global change programme, we have developed a project devoted to the study of the inorganic carbon cycle in the Bay of Biscay where coccolithophorid blooms occur frequently. The study focuses on processes associated with the oceanic production and dissolution of calcium carbonate, by combining field investigations, laboratory experiments and modelling efforts. Remote sensing demonstrates a close relationship between vertical mixing along the continental margin and the development of the phytoplankton bloom. We will present here, results of 14C incorporation experiments used to evaluate the rate of production of organic and inorganic particulate carbon, obtained during a coccolithophorid spring bloom in the investigated area. A tentative mass balance of the carbon fluxes for this area will be presented, confirming the importance that the calcium carbonate pump may play in the oceanic system. [less ▲]

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See detailEffect of stocking density on the dynamics of cannibalism in sibling larvae of Perca fluviatilis under controlled conditions
Baras, E.; Kestemont, P.; Mélard, Charles ULg

in Aquaculture (2003), 219(1-4), 241-255

The effect of stocking density (10, 31.6 and 100 larvae 1(-1); three replicates per treatment) on the day-by-day dynamics of survival, growth and cannibalism was examined in sibling perch larvae reared ... [more ▼]

The effect of stocking density (10, 31.6 and 100 larvae 1(-1); three replicates per treatment) on the day-by-day dynamics of survival, growth and cannibalism was examined in sibling perch larvae reared from eyed-egg stage in 100-1 cages (16L:8D, 20.0 +/- 0.5 degreesC, O-2 greater than or equal to 6.0 mg 1(-1); feeding in excess with live Artemia nauplii during the photophase) during the first 3 weeks of exogenous feeding. Larvae unable to achieve the transition to exogenous feeding died in between 7 and I I days post-hatch. Later, mortality from causes other than cannibalism never exceeded 1% day(-1). Cannibalism did not start before days 10 - 11 and first consisted in the incomplete ingestion of prey attacked tail first, exclusively. This type of cannibalism never caused losses higher than 2.0% of the initial stock, and ceased after days 16-18. From days 12-14 onwards, differential growth was apparent, and cannibals turned to complete cannibalism of small prey ingested head first, which caused greater losses (28-53% of the stock). Increasing the stocking density did not compromise growth and decreased the overall impact of cannibalism through several complementary mechanisms: (i) a postponed emergence of cannibalism, (ii) a lower proportion of cannibals in the population, and (iii) probably a lower rate of cannibalism per capita as predation was complicated and less directed at high stocking density. (C) 2003 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailPregnancy and the immune system: between tolerance and rejection
Thellin, Olivier ULg; Heinen, Ernst ULg

in Toxicology (2003), 185(3), 179-184

Interactions between the conceptus and the mother are bi-directional: the feto-placental tissues need nutrition and a suitable environment in homeostatic condition whereas the mother influenced by the ... [more ▼]

Interactions between the conceptus and the mother are bi-directional: the feto-placental tissues need nutrition and a suitable environment in homeostatic condition whereas the mother influenced by the placental factors adapts her metabolism and immune system. Many different mechanisms acting locally or at distance ensure tolerance of the semi-allogeneic graft by the maternal natural and adaptive immune defences. In front of this tolerance, mechanisms exist ensuring rejection of the conceptus by the mother (spontaneous abortion) through rupture of one or more tolerance mechanisms, notably in stress situations endangering the mother. Thus outcome of a pregnancy is dependent on efficiently working tolerance mechanisms, and rupture of such mechanisms can lead to rejection. The balance of influence leading either to tolerance or rejection is under control of internal (maternal and fetal) and external (environmental) factors. Rejection, if triggered, mainly occurs through immune-induced inflammation, tissue degradation and coagulation. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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See detailA new seismic analysis of Alpha Centauri
Thoul, Anne ULg; Scuflaire, Richard ULg; Noels-Grötsch, Arlette ULg et al

in Astronomy and Astrophysics (2003), 402(1), 293-297

Models of alpha Cen A & B have been computed using the masses determined by Pourbaix et al. (\cite{Po2002}) and the data derived from the spectroscopic analysis of Neuforge & Magain (\cite{Ne1997}). The ... [more ▼]

Models of alpha Cen A & B have been computed using the masses determined by Pourbaix et al. (\cite{Po2002}) and the data derived from the spectroscopic analysis of Neuforge & Magain (\cite{Ne1997}). The seismological data obtained by Bouchy & Carrier (\cite{Bo2001}, \cite{Bo2002}) do help improve our knowledge of the evolutionary status of the system. All the constraints are satisfied with a model which gives an age of about 6 Gyr for the binary. [less ▲]

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See detailSpectroscopic mode identification for the slowly pulsating B star HD 147394
Briquet, Maryline ULg; Aerts, C.; Mathias, P. et al

in Astronomy and Astrophysics (2003), 401

We present ground-based high-resolution high S/N spectra of the slowly pulsating B star HD 147394. Two frequencies are clearly found in the moments of the Si II 4128-4130 doublet: f[SUB]1[/SUB]=0.8008 c d ... [more ▼]

We present ground-based high-resolution high S/N spectra of the slowly pulsating B star HD 147394. Two frequencies are clearly found in the moments of the Si II 4128-4130 doublet: f[SUB]1[/SUB]=0.8008 c d[SUP]-1[/SUP] and f[SUB]2[/SUB]=0.7813 c d[SUP]-1[/SUP]. The frequency f[SUB]1[/SUB] is also found in the HIPPARCOS data. A third frequency is also present in our spectroscopic data: f[SUB]3[/SUB]=0.7175 c d[SUP]-1[/SUP] or its aliases due to the time sampling. A mode identification is performed by means of a new version of the moment method optimized for multiperiodic signals. It points towards several equivalent solutions of non-axisymmetric l <=3 for all three modes. We have too limited information to perform seismic modelling at this stage, but we do show that the different possibilities for the mode identifications are compatible with pulsational models for SPBs. Based on observations obtained with the spectrograph Aurélie attached to the 1.52-m telescope of the Observatoire de Haute-Provence, France. [less ▲]

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See detailAn X-ray investigation of the NGC 346 field in the Small Magellanic Cloud. II. The field population
Nazé, Yaël ULg; Hartwell, J. M.; Stevens, I. R. et al

in Astrophysical Journal (2003), 586(2, Part 1), 983-995

We present results from a Chandra observation of the NGC 346 cluster, which is the ionizing source of N66, the most luminous H II region and the largest star formation region in the SMC. In the first part ... [more ▼]

We present results from a Chandra observation of the NGC 346 cluster, which is the ionizing source of N66, the most luminous H II region and the largest star formation region in the SMC. In the first part of this investigation, we have analyzed the X-ray properties of the cluster itself and the remarkable star HD 5980, but the field contains additional objects of interest. In total, 75 X-ray point sources were detected in the Chandra observation: this is 5 times the number of sources detected by previous X-ray surveys. We investigate here their characteristics in detail. Because of high foreground absorption, the sources possess rather high hardness ratios. Their cumulative luminosity function appears generally steeper than that for the rest of the SMC at higher luminosities. Their absorption columns suggest that most of the sources belong to NGC 346. Using Digitized Sky Survey data and new UBVRI imaging with the ESO 2.2 m telescope, we also discovered possible counterparts for 32 of these X-ray sources and estimated a B spectral type for a large number of these counterparts. This tends to suggest that most of the X-ray sources in the field are in fact X-ray binaries. Finally, some objects show X-ray and/or optical variability, with a need for further monitoring. [less ▲]

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See detailLate Quaternary clay mineral record in Central Lake Baikal (Academician Ridge, Siberia)
Fagel, Nathalie ULg; Boski, T.; Likhoshway, L. et al

in Palaeogeography, Palaeoclimatology, Palaeoecology (2003), 193(1), 159-179

We investigated the mineralogical composition of two cores recovered on the Academician Ridge (Central Lake Baikal, Siberia). Sedimentological features show that the cores are unaffected by turbidity ... [more ▼]

We investigated the mineralogical composition of two cores recovered on the Academician Ridge (Central Lake Baikal, Siberia). Sedimentological features show that the cores are unaffected by turbidity currents. However, hemipelagic deposition is not continuous, but intermittently disturbed by syn- or post-sediment reworking (e.g., bioturbation, slumps, faulting). Such modes of deposition are consistent with the complex uplift history of the ridge. Bulk mineralogy suggests that terrigenous sediment supplies are constant through glacial/interglacial stages, and diluted by diatom-rich intervals related to warmer interglacial stages. The core stratigraphy is based on the correlation of the diatom zonation and opal abundance with the marine oxygen isotope reference curve SPECMAP. The similar to 8-m cores partly recover the last four interglacial/glacial cycles, i.e., since oxygen isotope stage 8. We test the use of clay minerals as a proxy for paleoclimatic reconstruction. The clays are more weathered during the diatom-rich intervals in agreement with warmer climate conditions. However, the mean clay composition does not change significantly through glacial/interglacial stages. This observation implies that, in the Academician Ridge sediments, a simple smectite/illite ratio (S/I) does not alone provide a reliable indicator of climatic variation. It reflects the complex clay assemblages, especially the smectite group, delivered to Central Lake Baikal. Smectites include primarily illite-smectite mixed layers, made of a mixture of montmorillonite and beidellite. According to their behavior after cation saturation, the illite-smectite mixed layers are primarily transformed smectites, with some neoformed smectites intermittently observed. In addition, Al-smectites occur in minor proportions. We conclude that the S/I ratio has a climatic significance only if it evolves in parallel with the weathering stage of the clays and is confirmed by a change in the composition of the smectites. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailL'hypertension artérielle essentielle peut-elle être prevenue?
Krzesinski, Jean-Marie ULg; Saint-Remy, Annie ULg

in Revue Médicale de Liège (2003), 58(4), 198-205

Prevalence of arterial hypertension is growing, in particular due to population ageing. Hypertension is a major risk factor for cardiovascular morbidity and mortality. Prevention is conceivable on a ... [more ▼]

Prevalence of arterial hypertension is growing, in particular due to population ageing. Hypertension is a major risk factor for cardiovascular morbidity and mortality. Prevention is conceivable on a theoretical basis by reduction or, if possible, prevention of excess weight, diet modifications, increased physical activity among other means. To be efficient, prevention should include an early detection of patients at risk and a long term assessment of efficacy requiring many efforts from both patients and physicians. [less ▲]

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See detailEnhanced nutritionally induced adipose tissue development in mice with stromelysin-1 gene inactivation.
Maquoi, Erik ULg; Demeulemeester, Diego; Vörös, Gabor et al

in Thrombosis and Haemostasis (2003), 89(4), 696-704

To investigate a potential role of stromelysin-1 (MMP-3) in development of adipose tissue, 5 week old male MMP-3 deficient mice (MMP-3(-/-)) and wild-type (MMP-3(+/+)) controls were kept on a high fat ... [more ▼]

To investigate a potential role of stromelysin-1 (MMP-3) in development of adipose tissue, 5 week old male MMP-3 deficient mice (MMP-3(-/-)) and wild-type (MMP-3(+/+)) controls were kept on a high fat diet (HFD) for 15 weeks. MMP-3(-/-) mice were hyperphagic and gained more weight than the MMP-3(+/+) mice. At the time of sacrifice, the body weight of the MMP-3(-/-) mice was significantly higher than that of the MMP-3(+/+) mice, as was the weight of the isolated subcutaneous (SC) and gonadal (GON) fat deposits. Significant adipocyte hypertrophy was observed in the GON but not in the SC adipose tissue of MMP-3(-/-) mice. Fasting plasma glucose and cholesterol levels were comparable in both genotypes, whereas triglyceride levels were significantly lower in MMP-3(-/-) mice. Staining with an endothelial cell specific lectin revealed a significantly higher blood vessel density and larger total stained area in the GON adipose tissues of MMP-3(-/-) mice. Thus, in a murine model of nutritionally induced obesity, MMP-3 impairs adipose tissue development, possibly by affecting food intake and/or adipose tissue-related angiogenesis. [less ▲]

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See detailMetabolic enzymes from psychrophilic bacteria: Challenge of adaptation to low temperatures in ornithine carbamoyltransferase from Moritella abyssi
Xu, Y.; Feller, Georges ULg; Gerday, Charles ULg et al

in Journal of Bacteriology (2003), 185(7), 2161-2168

The enzyme ornithine carbamoyltransferase (OTCase) of Motitella abyssi (OTCase(Mab)), a new, strictly psychrophilic and piezophilic bacterial species, was purified. OTCase(Mab) displays maximal activity ... [more ▼]

The enzyme ornithine carbamoyltransferase (OTCase) of Motitella abyssi (OTCase(Mab)), a new, strictly psychrophilic and piezophilic bacterial species, was purified. OTCase(Mab) displays maximal activity at rather low temperatures (23 to 25degreesC) compared to other cold-active enzymes and is much less thermoresistant than its homologues from Escherichia coli or thermophilic procaryotes. In vitro the enzyme is in equilibrium between a trimeric state and a dodecameric, more stable state. The melting point and denaturation enthalpy changes for the two forms are considerably lower than the corresponding values for the dodecameric Pyrococcus furiosus OTCase and for a thermolabile trimeric mutant thereof. OTCase(Mab) displays higher K-m values for ornithine and carbamoyl phosphate than mesophilic and thermophilic OTCases and is only weakly inhibited by the bisubstrate analogue delta-N-phosphonoacetyl-L-ornithine (PALO). OTCase(Mab) differs from other, nonpsychrophilic OTCases by substitutions in the most conserved motifs, which probably contribute to the comparatively high K-m values and the lower sensitivity to PALO. The K. for ornithine, however, is substantially lower at low temperatures. A survey of the catalytic efficiencies (k(cat)/K-m) of OTCases adapted to different temperatures showed that OTCase(Mab) activity remains suboptimal at low temperature despite the 4.5-fold decrease in the K-m value for ornithine observed when the temperature is brought from 20 to 5degreesC. OTCase(Mab) adaptation to cold indicates a trade-off between affinity and catalytic velocity, suggesting that optimization of key metabolic enzymes at low temperatures may be constrained by natural limits. [less ▲]

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See detailModernisation de l’interface citoyen - fonction publique: vers une intégration réfléchie des TIC
Lisein, Olivier ULg

in Pyramides (2003), 7(Printemps), 135-147

Le secteur public connaît, ces dernières années, une profonde et sérieuse remise en question. Nombreux sont ainsi les états où une politique générale de modernisation de la fonction publique est, ou va ... [more ▼]

Le secteur public connaît, ces dernières années, une profonde et sérieuse remise en question. Nombreux sont ainsi les états où une politique générale de modernisation de la fonction publique est, ou va être, instaurée. Au centre des préoccupations, le citoyen y bénéficie d’une place de choix: il fait l’objet de nombreuses attentions et peut donc désormais s’attendre à davantage d’égards. Qualité du service et satisfaction de la population deviennent en effet des concepts clés de la fonction publique. Pour atteindre ces objectifs, c’est toute la conception des relations qu’entretiennent citoyen et secteur public qui est revue. Les technologies de l’information et de la communication (TIC) présentent, dans ce cadre, de nombreux atouts. L’interface citoyen - secteur public s’en trouve modernisé avec, comme objectif avoué, une proximité accrue avec la population pour une plus grande satisfaction de celle-ci. Si ce recours aux TIC offre d’indéniables opportunités - tant en termes d’innovation de services que dans la manière dont ceux-ci sont prestés -, il n’en soulève pas moins certaines questions, l’accès aux services étant, pour le citoyen, complètement revu. Sur base d’une analyse critique de la littérature et de l’étude d’un cas concret, notre contribution entend questionner l’implémentation et la gestion des TIC dans l’interface citoyen - fonction publique. [less ▲]

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See detailIs laparoscopy still the gold standard in infertility assessment? A comparison of fertiloscopy versus laparoscopy in infertility. Results of an international multicentre prospective trial: the 'FLY' (Fertiloscopy-LaparoscopY) study.
Watrelot, A.; NISOLLE, Michelle ULg; Chelli, H. et al

in Human Reproduction (2003), 18(4), 834-9

BACKGROUND: The aim of this prospective multicentre study was to compare the two endoscopic techniques of laparoscopy and fertiloscopy in routine evaluation of the pelvis in infertile women. METHODS: A ... [more ▼]

BACKGROUND: The aim of this prospective multicentre study was to compare the two endoscopic techniques of laparoscopy and fertiloscopy in routine evaluation of the pelvis in infertile women. METHODS: A total of 92 women was selected in 14 University Hospitals to undergo fertiloscopy followed by transabdominal laparoscopy by a team of two surgeons in each hospital. RESULTS: A high degree of concordance was observed between these two techniques, in that if fertiloscopy did not detect any abnormalities, this was also confirmed by laparoscopy. Discordance was observed in similar numbers of cases: eight after laparoscopy and nine after fertiloscopy. The diagnostic index for fertiloscopy and laparoscopy was calculated; sensitivity (86 and 87% respectively) and negative predictive value (64 and 67% respectively) were similar. The kappa index was also calculated for each of the six structures/regions (right/left tube; right/left ovary; peritoneum of pouch of Douglas; posterior uterus), and concordance (0.78 to 0.91) was considered almost complete. CONCLUSIONS: These results confirm fertiloscopy as a minimally invasive safe procedure that may be considered as an alternative to diagnostic laparoscopy in the routine assessment of women without clinical or ultrasound evidence of pelvic disease. On the basis of the additional advantages of fertiloscopy, namely salpingoscopy or microsalpingoscopy, it is considered that fertiloscopy could replace laparoscopy as a routine procedure in such women. [less ▲]

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See detailDoes the Direction of Ductal Blood Flow Affect Regional Circulatory Hemodynamics in Duct Dependent Congenital Heart Disease?
Campbell, Morag; Rigo, Vincent ULg; Robertson, Murray

in Pediatric Research (2003, April), 53(4 Part 2/2), 471

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