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See detailThe Precthl's method for neurological examination of neonates
Battisti, Oreste ULg

Learning material (2005)

This lecture by video explains the method and presents samples of normal and abnormal states of neonates according to the neurological examination by the stidu of general movements of newborns

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See detailLes troubles de l'attention, l'hyperactivité chez l'enfant
Battisti, Oreste ULg

Learning material (2005)

Cours post-universitaire concernant l'hyperactivité: du diagnostic à la thérapeutique

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See detailAltered expression of type I insulin-like growth factor receptor in Crohn's disease
El Yafi, F.; Winkler, Rose ULg; Delvenne, Philippe ULg et al

in Clinical & Experimental Immunology (2005), 139(3), 526-533

The fibrotic and antiapoptotic effects of insulin-like growth factors (IGF) are mediated by type I IGF receptor (IGF-1R). IGFs could play a role in intestinal stricturing and in the maintenance of ... [more ▼]

The fibrotic and antiapoptotic effects of insulin-like growth factors (IGF) are mediated by type I IGF receptor (IGF-1R). IGFs could play a role in intestinal stricturing and in the maintenance of inflammation in Crohn's disease (CD). We aimed to describe IGF-1R expression in CD intestinal lesions, to compare it to other intestinal inflammatory diseases and to correlate it with fibrosis and apoptosis. IGF-1R expression and apoptosis (active caspase-3) were studied by immunohistochemistry. Surgical intestinal specimens [17 CD, nine controls, six diverticulitis and four ulcerative colitis (UC)] were used. IGF-1R was expressed transmurally mainly by inflammatory cells (IC) and smooth muscle cells, both in diseased intestine and controls. IGF-1R positive IC were increased in the mucosa and the submucosa of CD (P < 0.007), and in involved areas compared to uninvolved areas (P = 0.03). In UC, the number of IGF-1R positive IC was only increased in the mucosa, and was not different from controls in the submucosa. In diverticulitis, the number of IGF-1R positive IC did not differ from controls. In CD submucosa, IGF-1R expression in IC was inversely correlated with apoptosis in uninvolved areas (P = 0.01). Expression of IGF-1R in submucosal fibroblast-like cells, subserosal adipocytes and hypertrophic nervous plexi was specific for CD. We have shown a transmural altered expression of IGF-1R in CD. This may suggest a role for IGF-1R in the maintenance of chronic inflammation and stricture formation in CD. [less ▲]

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See detailArchitecture d'une boîte à outils d'algorithmes d'ingénierie de trafic et application au réseau GEANT
Skivée, Fabian; Balon, Simon ULg; Delcourt, Olivier et al

in Ingénierie des protocoles - Qualité de service, multimédia et mobilité (2005, March)

This paper presents the software architecture of a traffic engineering toolbox. The methods already included cover MPLS-based intra-domain traffic engineering (TE), but will soon cover IP-based TE and ... [more ▼]

This paper presents the software architecture of a traffic engineering toolbox. The methods already included cover MPLS-based intra-domain traffic engineering (TE), but will soon cover IP-based TE and inter-domain TE. This toolbox provides an open source software that allows an operator to test methods coming from the academic research. A researcher can also use the toolbox for comparing and promoting his/her TE algorithms. The toolbox is designed to be deployed as an on-line tool in a operational network or as a traffic engineering simulator. We present a case study of traffic optimisation on the GÉANT network that compares different routing algorithms, evaluates different protection cost, and analyses the worst-case link failure. [less ▲]

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See detailLa lutte des Sans Terre et le Forum social mondial
Schoonbroodt, Bénédicte ULg

Article for general public (2005)

Au Brésil, le Mouvement des paysans sans terre (MST) est un acteur puissant et incontournable des luttes sociales. Très impliqué dans la dynamique du Forum social mondial et dans les assemblées de ... [more ▼]

Au Brésil, le Mouvement des paysans sans terre (MST) est un acteur puissant et incontournable des luttes sociales. Très impliqué dans la dynamique du Forum social mondial et dans les assemblées de mouvements sociaux qui se tiennent à l’occasion de celui-ci, le MST était particulièrement présent et actif à Porto Alegre. Coup de projecteur sur ce mouvement emblématique de la lutte contre le néolibéralisme. [less ▲]

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See detailReconstruire la ville sur la ville - Recyclage des espaces dégradés
De Keersmaecker, M.-L.; Gérard, S.; Harou, R. et al

Report (2005)

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See detailReduced global copperativity is a common feature underlying the amyloidogenicity of pathogenic lysozyme mutations
Dumoulin, Mireille ULg; Canet, Denis; Last, Alexander M. et al

in Journal of Molecular Biology (2005), 346(3), 773-788

One of the 20 or so human amyloid diseases is associated with the deposition in vital organs of full-length mutational variants of the antibacterial protein lysozyme. Here, we report experimental data ... [more ▼]

One of the 20 or so human amyloid diseases is associated with the deposition in vital organs of full-length mutational variants of the antibacterial protein lysozyme. Here, we report experimental data that permit a detailed comparison to be made of the behaviour of two of these amyloidogenic variants, I56T and D67H, under identical conditions. Hydrogen/deuterium exchange experiments monitored by NMR and mass spectrometry reveal that, despite their different locations and the different effects of the two mutations on the structure of the native state of lysozyme, both mutations cause a cooperative destabilisation of a remarkably similar segment of the structure, comprising in both cases the beta-domain and the adjacent C-helix. As a result, both variant proteins populate transiently a closely similar, partially unstructured intermediate in which the beta-domain and the adjacent C-helix are substantially and simultaneously unfolded, whereas the three remaining a-helices that form the core of the a-domain still have their native-like structure. We show, in addition, that the binding of a camel antibody fragment, cAb-HuL6, which was raised against wild-type lysozyme, restores to both variant proteins the stability and cooperativity characteristic of the wild-type protein; as a consequence, it inhibits the formation of amyloid fibrils by both variants. These results indicate that the reduction in global cooperativity, an associated ability to populate transiently a specific, partly unfolded intermediate state under physiologically relevant conditions, is a common feature underlying the behaviour of these two pathogenic mutations. The formation of intermolecular interactions between lysozyme molecules that are in this partially unfolded state is therefore likely to be the fundamental trigger of the aggregation process that ultimately leads to the formation and deposition in tissue of amyloid fibrils. (C) 2004 Elsevier Ltd. All rights reserved. [less ▲]

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See detailStretching calorimetry studies of poly(epsilon-caprolactone)/organoclay nanocomposites
Karaman, Vitaly M; Privalko, Eleonora G; Valery, P Privalko et al

in Polymer (2005), 46(6), 1943-1948

Poly(epsilon-caprolactone)/montmorillonite nanocomposites, prepared by bulk ring-opening polymerization of epsilon-caprolactone in the presence of tin(II) 2-ethylhexanoate as a catalyst and hydroxy groups ... [more ▼]

Poly(epsilon-caprolactone)/montmorillonite nanocomposites, prepared by bulk ring-opening polymerization of epsilon-caprolactone in the presence of tin(II) 2-ethylhexanoate as a catalyst and hydroxy groups of ammonium tethers of organoclay acting as chain-growth centers, were characterized by the stretching calorimetry technique. In the range of elastic (reversible) deformations, experimental Young's moduli and linear thermal expansivities of both the intercalated and exfoliated nanocomposites could be fitted to the predictions of Chow's model assuming the apparent aspect ratio of clay nanoparticles of the order of 10. In the range of anelastic deformations, the values of the internal energy increments DeltaU/m for the intercalated nanocomposite lay somewhat below those for the corresponding neat polymer, while the DeltaU/m vs. epsilon plots for the exfoliated nanocomposite and for the corresponding neat polymer were nearly identical both in shape and in absolute values over the entire range of strains, up to the breaking strains epsilon(b). These data suggested higher and lower probabilities of interfacial debonding in the range of anelastic deformations for intercalated and exfoliated samples, respectively. [less ▲]

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See detailActualités dans le domaine de la fumure azotée
Bodson, Bernard ULg; Vancutsem, Françoise ULg; Destain, Jean-Pierre ULg et al

in Fumure et protection phytosanitaire des céréales (2005, February 23)

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See detailL'azote minéral du sol; sous froment d'hiver: Situation au 10 février 2005
Destain, Jean-Pierre ULg; Couvreur, Luc; Herman, Jean-Luc et al

in Fumure et protection phytosanitaire des céréales (2005, February 23)

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See detailFongicides: Protection contre la septoriose en froment: quelle stratégie vis-à-vis de la résistance aux strobilurines?
Moreau, Jean-Marc; Bodson, Bernard ULg; Vancutsem, Françoise ULg

in Fumure et protection phytosanitaire des céréales (2005, February 23)

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See detailLes conseils de fumure azotée
Bodson, Bernard ULg; Destain, Jean-Pierre ULg; Vancutsem, Françoise ULg et al

in Fumure et protection phytosanitaire des céréales (2005, February 23)

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See detailFongicides: Schéma de protection fongicide et sensibilité variétale
Vancutsem, Françoise ULg; Bodson, Bernard ULg; Moreau, Jean-Marc

in Fumure et protection phytosanitaire des céréales (2005, February 23)

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See detailVariétés, phytotechnie et rendement en paille du froment d'hiver
Vancutsem, Françoise ULg; Bodson, Bernard ULg; Minsier, François et al

in Fumure et protection phytosanitaire des céréales (2005, February 23)

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See detailIncreased Northern Hemispheric carbon monoxide burden in the troposphere in 2002 and 2003 detected from the ground and from space
Yurganov, Leonid N.; Duchatelet, Pierre ULg; Dzhola, A. V. et al

in Atmospheric Chemistry and Physics (2005), 5

Carbon monoxide total column amounts in the atmosphere have been measured in the High Northern Hemisphere (30degrees - 90degrees N, HNH) between January 2002 and December 2003 using infrared spectrometers ... [more ▼]

Carbon monoxide total column amounts in the atmosphere have been measured in the High Northern Hemisphere (30degrees - 90degrees N, HNH) between January 2002 and December 2003 using infrared spectrometers of high and moderate resolution and the Sun as a light source. They were compared to ground-level CO mixing ratios and to total column amounts measured from space by the Terra/MOPITT instrument. All these data reveal increased CO abundances in 2002 - 2003 in comparison to the unperturbed 2000 - 2001 period. Maximum anomalies were observed in September 2002 and August 2003. Using a simple two-box model, the corresponding annual CO emission anomalies (referenced to 2000 - 2001 period) have been found equal to 95 Tg in 2002 and 130 Tg in 2003, thus close to those for 1996 and 1998. A good correlation with hot spots detected by a satellite radiometer allows one to assume strong boreal forest fires, occurred mainly in Russia, as a source of the increased CO burdens. [less ▲]

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See detailLong-term fluvastatin reduces the hazardous effect of renal impairment on four-year atherosclerotic outcomes (a LIPS substudy)
Lemos, P. A.; Serruys, P. W.; de Feyter, P. et al

in American Journal of Cardiology (2005), 95(4), 445-451

Mild renal impairment is an important risk factor for late cardiovascular complications. This substudy of the Lescol Intervention Prevention Study (LIPS) assessed the effect of fluvastatin on outcome of ... [more ▼]

Mild renal impairment is an important risk factor for late cardiovascular complications. This substudy of the Lescol Intervention Prevention Study (LIPS) assessed the effect of fluvastatin on outcome of patients who had renal dysfunction and those who did not. Complete data for creatinine clearance calculation. (Cockcroft=Gault formula) were available for 1,558 patients (92.9% of the LIPS population). Patients were randomized to fluvastatin or placebo after successful completion of a first percutaneous coronary intervention. Follow-up time was, 3 to 4 years. The effect of baseline creatinine clearance on coronary atherosclerotic events (cardiac death, non-fatal myocardial infarction, and coronary reinterventions not related to restenosis) was evaluated. Baseline creatinine clearance (logarithmic transformation) was inversely associated with an incidence of adverse events among patients who received, placebo. (hazard ratio 0.99, 95% confidence interval 0.982 to 0.998, p = 0.01). However, no association was noted between creatinine clearance and the incidence of adverse events among patients who received fluvastatin (hazard ratio 1.0, 95% confidence interval 0.99 to 1.0, p = 0.63). No further deterioration in creatinine clearance was observed during follow-up; regardless of baseline renal function or allocated treatment. Occurrence of adverse events was not related to changes in renal function during follow-up. Fluvastatin therapy markedly decreased the risk of coronary atherosclerotic events after percutaneous intervention in: patients who had lower values of creatinine clearance at baseline: The benefit of fluvastatin was unrelated to any effect on renal function. (C) 2005 by Excerpta Medica Inc. [less ▲]

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See detailWhy does the red algal plastid lineage lack plastocyanin?
Baurain, Denis ULg; Demoulin, Vincent ULg

Conference (2005, February 03)

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See detailL'astronomie dans le monde
Manfroid, Jean ULg

Article for general public (2005)

Ultrasons solaires, GMT, Caméra infrarouge géante, Mars, Titan et Dioné, Japet, les anneaux, Mimas, Huygens sur Titan, découverte d'un nouveau monde, Swift débute, pulsar 3C58, Jeunes galaxies, 2004 MN4 ... [more ▼]

Ultrasons solaires, GMT, Caméra infrarouge géante, Mars, Titan et Dioné, Japet, les anneaux, Mimas, Huygens sur Titan, découverte d'un nouveau monde, Swift débute, pulsar 3C58, Jeunes galaxies, 2004 MN4 near miss, volcans martiens, Et de cinq Champs magnétiques et nébuleuses planétaires, [less ▲]

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See detailOctreotide (long-acting release formulation) treatment in patients with graves' orbitopathy: clinical results of a four-month, randomized, placebo-controlled, double-blind study.
Wemeau, J. L.; Caron, P.; Beckers, Albert ULg et al

in Journal of Clinical Endocrinology and Metabolism (2005), 90(2), 841-848

There are few effective, safe modalities for the management of Graves' ophthalmopathy (GO), a cell-mediated immune comorbidity of thyroid disease. Somatostatin analogs inhibit lymphocyte proliferation and ... [more ▼]

There are few effective, safe modalities for the management of Graves' ophthalmopathy (GO), a cell-mediated immune comorbidity of thyroid disease. Somatostatin analogs inhibit lymphocyte proliferation and activation, and accumulate in the orbital tissue of patients with GO. A double-blind, placebo-controlled study of a long-acting somatostatin analog [16 wk of long-acting release formulation of octreotide (octreotide-LAR)] was conducted in 51 patients with mild active GO with the aim of preventing deterioration and precluding the need for more aggressive therapeutic modalities, such as glucocorticoids or radiotherapy. No treatment effect was observed for the primary end point (a composite parameter defining the outcome as either success or failure on the basis of changes in class/grade of the severity index and Clinical Activity Scale of GO). The Clinical Activity Scale score was reduced for patients treated with octreotide-LAR, but without any significant difference with respect to patients receiving placebo. However, octreotide-LAR significantly reduced proptosis (as measured by exophthalmometry). This was associated with nonsignificant differences in favor of octreotide-LAR in a series of proptosis-related parameters: class III grade, opening of the upper eyelid, the difference in ocular pressure between primary position and upgaze, and extraocular muscle involvement. By magnetic resonance imaging evaluation the extraocular muscle volumes appeared reduced, but nonsignificantly. No significant correlation between the initial uptake of the somatostatin analog indium-labeled and the response to treatment was observed. One patient in the octreotide-LAR group developed gallstones. In this study, octreotide-LAR did not seem suitable to mitigate activity in mild GO. Surprisingly, it significantly reduced proptosis, one of the most debilitating symptoms of GO. Additional studies are warranted to define the benefit to risk ratio of the somatostatin analogs in this indication. [less ▲]

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