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See detailToxicity at three years with and without irradiation of the internal mammary and medial supraclavicular lymph node chain in stage i to III breast cancer (EORTC trial 22922/10925)
Matzinger, O.; Heimsoth, I.; Poortmans, P. et al

in Acta Oncologica (2010), 49(1), 24-34

Introduction. The EORTC 22922/10925 trial investigated the potential survival benefit and toxicity of elective irradiation of the internal mammary and medial supraclavicular (IM-MS) nodes Accrual ... [more ▼]

Introduction. The EORTC 22922/10925 trial investigated the potential survival benefit and toxicity of elective irradiation of the internal mammary and medial supraclavicular (IM-MS) nodes Accrual completed in January 2004 and first results are expected in 2012. We present the toxicity reported until year 3 after treatment. Patients and methods. At each visit, toxicity was reported but severity was not graded routinely. Toxicity rates and performance status (PS) changes at three years were compared by χ2 tests and logistic regression models in all the 3 866 of 4 004 patients eligible to the trial who received the allocated treatment. Results. Only lung (fibrosis; dyspnoea; pneumonitis; any lung toxicities) (4.3% vs. 1.3%; p < 0.0001) but not cardiac toxicity (0.3% vs. 0.4%; p = 0.55) significantly increased with IM-MS treatment. No significant worsening of the PS was observed (p = 0.79), suggesting that treatment-related toxicity does not impair patient's daily activities. Conclusions. IM-MS irradiation seems well tolerated and does not significantly impair WHO PS at three years. A follow-up period of at least 10 years is needed to determine whether cardiac toxicity is increased after radiotherapy. [less ▲]

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See detailComparison of active and electrostimulated recovery strategies after fatiguing exercise
Vanderthommen, Marc ULg; Makrof, Souleyma; Demoulin, Christophe ULg

in Journal of Sports Science & Medicine (2010), 9

The purpose of this study was to compare an electrostimulated to an active recovery strategy after a submaximal isometric fatiguing exercise. Nineteen healthy men completed three sessions (separated by at ... [more ▼]

The purpose of this study was to compare an electrostimulated to an active recovery strategy after a submaximal isometric fatiguing exercise. Nineteen healthy men completed three sessions (separated by at least 4 weeks) which included a knee extensors provocation exercise consisting of 3 sets of 25 isometric contractions. Contraction intensity level was fixed respectively at 60%, 55% and 50% of previously determined maximal voluntary contraction for the first, second and third sets. This provocation exercise was followed by either an active (AR) recovery (25 min pedaling on a cycle ergometer), an electrostimulated (ESR) recovery (25-min continuous and nontetanic (5 Hz) stimulation of the quadriceps) or a strictly passive recovery (PR). Peak torques of knee extensors and subjective perception of muscle pain (VAS, 0-10) were evaluated before (pre-ex), immediately after the provocation exercise (post-ex), after the recovery period (post-rec), as well as 75 minutes (1h15) and one day (24h) after the exercise bout. Time course of peak torque was similar among the different recovery modes: ~ 75% of initial values at post-ex, ~ 90% at post-rec and at 1h15. At 24h, peak torque reached a level close to baseline values (PR: 99.1 ± 10.7%, AR: 105.3 ± 12.2%, ESR: 104.4 ± 10.5%). VAS muscle pain scores decreased rapidly between post-ex and postrec (p < 0.001); there were no significant differences between the three recovery modes (p = 0.64). In conclusion, following a submaximal isometric knee extension exercise, neither electrostimulated nor active recovery strategies significantly improved the time course of muscle function recovery. [less ▲]

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See detailEducation on sensor-augmented pump use improves glucose control in type-1 diabetic patients.
Thielen, Vinciane ULg; Place, J.; Gerbaud, S. et al

in Diabètes & Métabolism (2010)

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See detailIs the ADA/EASD algorithm for the management of type 2 diabetes (January 2009) based on evidence or opinion? A critical analysis.
Schernthaner, G.; Barnett, A. H.; Betteridge, D. J. et al

in Diabetologia (2010)

The ADA and the EASD recently published a consensus statement for the medical management of hyperglycaemia in patients with type 2 diabetes. The authors advocate initial treatment with metformin ... [more ▼]

The ADA and the EASD recently published a consensus statement for the medical management of hyperglycaemia in patients with type 2 diabetes. The authors advocate initial treatment with metformin monotherapy and lifestyle modification, followed by addition of basal insulin or a sulfonylurea if glycaemic goals are not met (tier 1 recommendations). All other glucose-lowering therapies are relegated to a secondary (tier 2) status and only recommended for selected clinical settings. In our view, this algorithm does not offer physicians and patients the appropriate selection of options to individualise and optimise care with a view to sustained control of blood glucose and reduction both of diabetes complications and cardiovascular risk. This paper critically assesses the basis of the ADA/EASD algorithm and the resulting tiers of treatment options. [less ▲]

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See detailPioglitazone Use in Combination with Insulin in the Prospective Pioglitazone Clinical Trial in Macrovascular Events Study (PROactive19).
Charbonnel, B.; Defronzo, R.; Davidson, J. et al

in Journal of Clinical Endocrinology and Metabolism (2010)

Objective: In this post hoc analysis, we examined insulin requirements and regimens, glycemic control, cardiovascular outcomes, and safety in the patients treated with insulin at baseline in the ... [more ▼]

Objective: In this post hoc analysis, we examined insulin requirements and regimens, glycemic control, cardiovascular outcomes, and safety in the patients treated with insulin at baseline in the Prospective Pioglitazone Clinical Trial in Macrovascular Events study. Design: The Prospective Pioglitazone Clinical Trial in Macrovascular Events study was a double-blind, placebo-controlled outcome study (mean follow-up 34.5 months) in 5238 high-risk patients with type 2 diabetes randomized to pioglitazone (force titrated to 45 mg) or placebo. One third of the total population (pioglitazone 864; placebo 896) were receiving insulin at baseline. Results: A rapid and sustained decrease in insulin dose was observed with pioglitazone vs. a progressive increase with placebo. By study end, the mean insulin dose was lower with pioglitazone (42 vs. 55 U/d with placebo; P < 0.0001). The insulin regimen (number on insulin, need for multiple injections, and reduction in oral agents) had been simplified vs. placebo; nevertheless, a greater glycosylated hemoglobin reduction was observed with pioglitazone (-0.93%) vs. placebo (-0.45%; P < 0.0001). At the final visit, insulin had been discontinued in 9% of pioglitazone vs. 2% of placebo patients (P < 0.0001). More insulin-resistant patients (defined as poorly controlled type 2 diabetes despite high doses of insulin) in the pioglitazone plus insulin group showed the greatest glycosylated hemoglobin decline. There were nonsignificant reductions with pioglitazone relative to placebo in the cardiovascular primary (hazard ratio 0.86; 95% confidence interval 0.71, 1.04; P = 0.1198) and main secondary (hazard ratio 0.85; 95% confidence interval 0.67, 1.08; P = 0.1831) end points in insulin-treated patients. The rates of overall heart failure, edema, and hypoglycemia were higher with pioglitazone [13.5 vs 10.5% (P = 0.0489); 30.8 vs. 18.2% (P < 0.0001); and 42.1 vs 29.0% (P < 0.0001), respectively], but there were no significant differences in serious events. Conclusions: Pioglitazone use in combination with insulin resulted in a sustained improved glycemic control and allowed the treatment regimens to be simplified and the insulin doses reduced. [less ▲]

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See detailExercise-induced changes in degenerative mitral regurgitation
Magne, Julien ULg; Lancellotti, Patrizio ULg; Pierard, Luc ULg

in Journal of the American College of Cardiology (2010), 56(4), 300-309

OBJECTIVES: We sought to quantify exercise-induced changes in patients with degenerative mitral regurgitation (MR), to examine the relationship between exercise-induced changes in MR and in systolic ... [more ▼]

OBJECTIVES: We sought to quantify exercise-induced changes in patients with degenerative mitral regurgitation (MR), to examine the relationship between exercise-induced changes in MR and in systolic pulmonary artery pressure (PAP), and to identify their potential impact on symptom-free survival. BACKGROUND: MR severity can change during exercise in patients with functional MR. Quantified changes in MR severity during exercise remain undetermined in patients with degenerative MR. METHODS: Resting and bicycle exercise Doppler-echocardiography were performed in 61 asymptomatic patients (age 62+/-14 years) with moderate to severe degenerative MR (i.e., mitral valve prolapse or flail). Mitral regurgitation was quantified at rest and exercise with effective regurgitant orifice (ERO) area and regurgitant volume calculated with the proximal isovelocity surface area (EROP) and the quantitative Doppler (EROD) methods. RESULTS: At rest, EROP and EROD were well-correlated (r=0.87, p<0.0001), but EROD was larger than EROP (54+/-21 mm2 vs. 42+/-24 mm2, p<0.0001). During exercise, mean ERO and regurgitant volume markedly increased in 32% of patients by >or=10 mm2 and >or=15 ml, respectively. There was good correlation between exercise EROP and EROD (r=0.84, p<0.0001). Changes in systolic PAP were correlated with changes in ERO and regurgitant volume (r=0.59, p=0.02 and r=0.60, p=0.02). Patients with a marked increase in regurgitant volume during exercise had lower symptom-free survival than those in whom MR decreased or remained unchanged (p=0.0015). CONCLUSIONS: Degenerative MR might be dynamic and increases during exercise in one-third of patients. Marked changes in MR severity are associated with exercise-induced changes in systolic PAP and reduced symptom-free survival. [less ▲]

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See detailEmotion and false memories: affective valence influences participant’s susceptibility to false memories and illusory recollection.
Dehon, Hedwige ULg; Laroi, Frank ULg; Van der Linden, Martial ULg

in Emotion (2010), 10(5), 627-639

This study examined the influence of emotional valence on the production of DRM false memories (Roediger & McDermott, 1995). Participants were presented with neutral, positive or negative DRM lists for a ... [more ▼]

This study examined the influence of emotional valence on the production of DRM false memories (Roediger & McDermott, 1995). Participants were presented with neutral, positive or negative DRM lists for a later recognition (Experiment 1) or recall (Experiment 2) test. In both experiments, confidence and recollective experience (i.e., “Remember-Know” judgements; Tulving, 1985) were also assessed. Results consistently showed that, compared with neutral lists, affective lists induced more false recognition and recall of non presented critical lures. Moreover, although confidence ratings did not differ between the false remembering from the different kinds of lists, “Remember” responses were more often associated with negative than positive and neutral false remembering of the critical lures. In contrast, positive false remembering of the critical lures was more often associated with “Know” responses. These results are discussed in light of the Paradoxical Negative Emotion (PNE) hypothesis (Porter et al., 2008). [less ▲]

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See detailThe HelpED Study: Degree of Agreement Between Patients, Partners, and Physicians on
Claes, Hubert; Andrianne, Robert ULg; Opsomer, Reinier

Poster (2010)

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See detailThe HelpED Study: Impact of Change in Erection Hardness on the Self-Esteem,
Opsomer, Reinier; Claes, Hubert; Andrianne, Robert ULg

Poster (2010)

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See detailProteomic analysis of human pancreas cancers for the identification of targetable biomarkers
Castronovo, Vincenzo ULg; Wang, Ying Hong; Musmeci, Davide et al

(2010)

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See detailL’apport d’une université au développement régional. Le cas de Liège
Merenne-Schoumaker, Bernadette ULg

in Mutations. Mémoires et perspectives du Bassin minier (2010), 2/2010

L’impact d’une université sur son territoire est étudié depuis près de 40 ans, les travaux se focalisant principalement sur les aspects économiques de cet impact et parfois sur la formation, la culture ... [more ▼]

L’impact d’une université sur son territoire est étudié depuis près de 40 ans, les travaux se focalisant principalement sur les aspects économiques de cet impact et parfois sur la formation, la culture, la santé ou encore l’image de marque. L'objectif de cet article est de mettre en évidence succinctement les problématiques et méthodologies de ces travaux, puis d'analyser le cas de l'Université de Liège [less ▲]

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See detailComment les parents, les enseignants et les cliniciens évaluent les troubles du comportement externalisé du jeune enfant ? Etude de la variabilité des jugements évaluatifs et de son impact sur le développement de l’enfant
Roskam, Isabelle; Stievenart, Marie ULg; Meunier, Jean-Christophe et al

in Pratiques Psychologiques (2010), 16

Cette contribution questionne nos pratiques d’évaluation du comportement chez le jeune enfant. Les données concernant le comportement de 118 enfants ont été collectées par questionnaires et observation ... [more ▼]

Cette contribution questionne nos pratiques d’évaluation du comportement chez le jeune enfant. Les données concernant le comportement de 118 enfants ont été collectées par questionnaires et observation auprès de leurs parents, leurs enseignants et les cliniciens lors du recrutement et après 12 mois. Les résultats indiquent une variabilité importante entre les jugements évaluatifs des différents informateurs et un impact négatif de cette variabilité sur le développement ultérieur de l’enfant. Les résultats plaident en faveur d’une procédure multi-informateurs et multiméthodes dont les implications sont discutées sur le plan clinique. [less ▲]

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See detailModel-free Monte Carlo-like policy evaluation
Fonteneau, Raphaël ULg; Murphy, Susan A.; Wehenkel, Louis ULg et al

in 29th Benelux Meeting on Systems and Control (2010)

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See detailRevision and validation of the Family Apperception Test: some psychometric properties.
Roskam, Isabelle; Stievenart, Marie ULg; Deschuyteneer, Laurence et al

in The Family Journal (2010), 18(3),

The Family Apperception Test (FAT) is a projective assessment procedure based on the family system theory. FAT allows the subjects’ affects and feelings about their family to be assessed. The original ... [more ▼]

The Family Apperception Test (FAT) is a projective assessment procedure based on the family system theory. FAT allows the subjects’ affects and feelings about their family to be assessed. The original version and its French translation removed some of the conceptual and psychometric limitations of previous projective tests and family assessment procedures but several questions remained. The current study proposes several modifications to the conceptual background, administration, coding procedure, and standardization of the FAT, which considerably improve its psychometric properties. Data were collected on 168 typical and clinical children in the French-speaking part of Belgium. The results provide significant evidence for inter- and intra-assessor reliability; the factorial analysis and the internal consistency of the revised version were good; the FAT enabled us to discriminate between typical children and those in the clinical sample. The discussion focuses on the interest and limits of the quantitative coding procedure, based on several categories conceptualized as risk versus protective factors. The FAT is characterized by a complementary approach—both quantitative and qualitative—to the children and their families. [less ▲]

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See detailConcepts et modèle de données du logiciel NotaBene. Spécification technique
Mazziotta, Nicolas ULg

Computer development (2010)

Ce document définit les notions ainsi que la terminologie linguistique et technique mobilisés par le logiciel d’annotation NotaBene. Le logiciel a été développé avec comme objectif de permettre ... [more ▼]

Ce document définit les notions ainsi que la terminologie linguistique et technique mobilisés par le logiciel d’annotation NotaBene. Le logiciel a été développé avec comme objectif de permettre l’annotation de textes anciens, la plupart du temps transmis par un medium concret. Les notions abordées ci- dessous devront être repensées s’il fallait les adapter aux ressources électroniques. [less ▲]

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See detailAsymmetric Optical Second-Harmonic Generation from Chiral G-Shaped Gold Nanostructures
Valev, V. K.; Silhanek, Alejandro ULg; Verellen, N. et al

in Physical Review Letters (2010), 104(12),

We present a new electromagnetic phenomenon-the asymmetric second-harmonic generation from planar chiral structures. The effect consists in distinguishing the handedness of a chiral material by rotating ... [more ▼]

We present a new electromagnetic phenomenon-the asymmetric second-harmonic generation from planar chiral structures. The effect consists in distinguishing the handedness of a chiral material by rotating the sample in an experiment involving solely linearly polarized light. This phenomenon originates in the surface plasmon resonance of chiral gold nanostructures, where homodyne interference of anisotropic and chiral electric and/or magnetic multipoles appears to play an important role. [less ▲]

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See detailAppropriation et vulgarisation d'outils d'aide à la décision dans la co-gestion du périmètre irrigué de la Vallée du Kou (sud-ouest du Burkina Faso)
Wellens, Joost ULg; Nitcheu, Martial; Diallo, Mamadou et al

Report (2010)

Dans le cadre d’un programme national de sécurité alimentaire datant des années 60, un périmètre rizicole irrigué de 1.200 ha, appelé la Vallée du Kou, a été établi dans le Sud-ouest du Burkina Faso (Bama ... [more ▼]

Dans le cadre d’un programme national de sécurité alimentaire datant des années 60, un périmètre rizicole irrigué de 1.200 ha, appelé la Vallée du Kou, a été établi dans le Sud-ouest du Burkina Faso (Bama). Long temps conjointement géré par l’Etat et toute une série d’agences d’aide au développement, tout appui s’est brutalement arrêté en 1993 laissant les agriculteurs à peine préparé pour assumer la relève de la gestion. Le résultat : un ancien beau périmètre succombe dans un théâtre typique de gestion anarchique. Différentes structures de coopératives ont tenté depuis, de gérer leur petite part du périmètre passant outre aux règles et sans aucun respect pour leurs voisins. Les travaux de maintenance avaient disparu, les récoltes étaient en baisses et l’eau disponible ne satisfaisaient plus aux besoins laissant presque un quart des champs en jachères. Observant l’état de plus en plus dégradé du périmètre et conscient de leurs faibles capacités de gestion, l’Union des Coopératives Rizicole de Bama (UCRB) s’est finalement adressée à un opérateur externe (AEDE), expérimenté dans le domaine de l’eau et de l’agriculture, pour obtenir un appui. Cette assistance est déployée à deux niveaux. Premièrement, l’installation d’un conseiller permanent en irrigation sur le périmètre intervenant comme appui technique auprès des agriculteurs et chargé d’établir un inventaire technique et objectif sur l’état du périmètre et de sa gestion. Deuxièmement, des études plus techniques ont été établies afin de quantifier les problèmes de gestion et de proposer des solutions en termes d’occupations des parcelles et de distribution d’eau plus durables. Ceci a notamment nécessité la mise en place et l’application de l’outil de gestion de périmètre irrigué SIMIS. A travers les différentes étapes, des réunions participatives ont été organisées au niveau de l’union des coopératives ainsi qu’au niveau des différentes coopératives. Les producteurs ont été écoutés, et des plans et solutions proposés et discutés. Si nécessaire, des compromis étaient cherchés et représentés pour approbation. Quelques mois seulement après la mise en place de cet appui-conseil, une augmentation de l’occupation des parcelles dans le périmètre a été constatée et une distribution en eau plus équitable enregistrée. Côté producteurs, une satisfaction générale a été notée et ils souhaitent à présent s’engager davantage dans cette gestion externe du périmètre. D’autres périmètres ont également manifesté leur intérêt. [less ▲]

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See detailProblem of applying sodium selenate to increase selenium concentrations in grassland plant in Southern Belgium
Hambuckers, Alain ULg; Dotreppe, Olivier ULg; Istasse, Louis ULg

in Communications in Soil Science & Plant Analysis (2010), 41

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See detailSynthèse des campagnes de suivi des rendements à la Vallée du Kou (Burkina Faso): saison humide 2009 et saison sèche 2010
Nitcheu, Martial; Midekor, Akoly; Sawadogo, Brehima et al

Report (2010)

Dans l’optique de mesurer l’impact des activité s menées par le Projet GEeau et l’AEDE/OE pour la gestion de l’eau sur le périmètre irrigué de Bama en campagne sèche, des suivis de rendement ont été ... [more ▼]

Dans l’optique de mesurer l’impact des activité s menées par le Projet GEeau et l’AEDE/OE pour la gestion de l’eau sur le périmètre irrigué de Bama en campagne sèche, des suivis de rendement ont été initiés par ces derniers pour les campagnes humide 2009 et sèche 2010, en appui à l’équipe technique déployée sur la plaine par l’administration. Le présent document donne les résultats obtenus. Une comparaison avec les résultats antérieurs trouvés dans la littérature et les résultats obtenus en campagne humide où l’eau est à priori un facteur peu limitant, permet de dégager l’impact réel des efforts menés en contre saison où les problèmes d’eau sont les plus cruciaux. [less ▲]

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See detailSpectrométrie de masse MALDI-TOF en bactériologie clinique ou comment identifier une bactérie en une minute
Descy, Julie ULg; Meex, Cécile ULg; Melin, Pierrette ULg et al

in Revue Médicale de Liège (2010), 65(Suppl. Synthèse 2010), 29-34

The major application of MALDI-TOTOF mass spectrometry in clinical microbiology is the bacterial identification based on the analysis of all their proteins (ribosomal and membrane-associated proteins ... [more ▼]

The major application of MALDI-TOTOF mass spectrometry in clinical microbiology is the bacterial identification based on the analysis of all their proteins (ribosomal and membrane-associated proteins). This technology allows the identification of most of bacteria within a few minutes. The method is fast, accurate, reliable and cost-effective by comparison to conventional phenotypic techniques. Other applications of MALDI-TOF mass spectrometry are still under development, as the detection of bacterial toxins or resistance mechanisms to antimicrobial agents. [less ▲]

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