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See detailInterest and feasibility of a modified supine position for posterior cranial fossa surgical procedures.
Graftieaux, J-P; Litré, Claude Fabien ULg; Gomis, P et al

in Annales Françaises d'Anesthésie et de Réanimation (2004)

The sitting position is considered as a gold standard for posterior fossa surgical procedures. However, in order to decrease the incidence rate of cerebral venous air embolisms, we presently described a ... [more ▼]

The sitting position is considered as a gold standard for posterior fossa surgical procedures. However, in order to decrease the incidence rate of cerebral venous air embolisms, we presently described a modified supine position allowing performance of posterior fossa surgical procedures. Such position is easy and quickly performed with light variations of blood pressure: patients are placed supine with paddings inserted under ipsilateral shoulder and buttock, and head turned to other side of surgical site. Dural tension estimated by the surgeon was always considered as good. We performed more than 100 surgical procedures in this position without any complication for 10 years. [less ▲]

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See detailNumerical modelling of two-way reinforced concrete slabs in fire
Lim, Linus; Buchanan, Andrew; Moss, Peter et al

in Engineering Structures (2004), 26(8), 1081-1091

This paper describes numerical modelling of the fire behaviour of two-way reinforced concrete slabs using a special purpose non-linear finite-element program, SAFIR. Several two-way reinforced concrete ... [more ▼]

This paper describes numerical modelling of the fire behaviour of two-way reinforced concrete slabs using a special purpose non-linear finite-element program, SAFIR. Several two-way reinforced concrete and composite steel-concrete slabs are tested under exposure to the ISO standard fire in order to validate the shell finite element in the SAFIR program. The modelling results showed agreement with the fire tests and demonstrate that the SAFIR shell element can be used to predict tensile membrane behaviour of two-way reinforced concrete slabs in fire conditions. The analyses show that two-way slabs have excellent fire resistance if they deform in double curvature and develop tensile membrane action. (C) 2004 Elsevier Ltd. All rights reserved. [less ▲]

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See detailPrevalence and demographic features of childhood growth hormone deficiency in Belgium during the period 1986-2001
Thomas, Muriel; Massa, Guy; Craen, Margarita et al

in European Journal of Endocrinology (2004), 151(1), 67-72

Objective: Since the availability of recombinant human growth hormone (rhGH) all children with growth hormone deficiency (GHD) living in Belgium are offered rhGH treatment after approval by a peer-review ... [more ▼]

Objective: Since the availability of recombinant human growth hormone (rhGH) all children with growth hormone deficiency (GHD) living in Belgium are offered rhGH treatment after approval by a peer-review board. In this study, we evaluated the prevalence and demographic features of childhood GHD in Belgium during the period 1986-2001 and we compared them with the data from other countries. Methods: Diagnostic, demographic and baseline auxological data of 714 children diagnosed as having GHD between 1986 and 2001 were retrieved from the database of the Belgian Study Group for Paediatric Endocrinology. Results: The prevalence of GHD in Belgium was estimated to be 1/5600. The origin of GHD was idiopathic (idGHD) in 41% of the patients, congenital (congGHD) in 20% and acquired (acqGHD) in 35%. During the first 4 years (1986-1989) more patients were classified as idGHD; thereafter the distribution between the three aetiology groups did not change. In all groups, boys outnumbered girls but this preponderance was especially pronounced in congGHD patients (male:female = 4:1) with a central malformation that associates an anterior pituitary hypoplasia, a missing, fine or normal pituitary stalk and an ectopic posterior pituitary. Thirteen percent of the patients with idGHD, 50% with congGHD and 52% with acqGHD had multiple pituitary deficiencies. Patients with congGHD were the youngest (mean+/-S.D. age: 6.5+/-4.7 years) and were the shortest (-3.0+/-1.3 standard deviation score (SDS)) at the start of rhGH treatment. There was no time trend over the studied period for age and height at onset of GH therapy. Conclusion: In Belgium, the prevalence of childhood GHD can be estimated as 1/5600 which is comparable to other recent surveys. The yearly number of new patients for the different aetiologies and the auxological parameters have remained relatively constant over the last 16 years. [less ▲]

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See detailPhase I/II trial of immunogenicity of a human papillomavirus (HPV) type 16 E7 protein-based vaccine in women with oncogenic HPV-positive cervical intraepithelial neoplasia
Hallez, Sophie; Simon, Philippe; Maudoux, Frédéric et al

in Cancer Immunology, Immunotherapy (2004), 53(7), 642-650

Purpose: Infection with oncogenic human papillomavirus (HPV) and HPV-16 in particular is a leading cause of anogenital neoplasia. High-grade intraepithelial lesions require treatment because of their ... [more ▼]

Purpose: Infection with oncogenic human papillomavirus (HPV) and HPV-16 in particular is a leading cause of anogenital neoplasia. High-grade intraepithelial lesions require treatment because of their potential to progress to invasive cancer. Numerous preclinical studies have demonstrated the therapeutic potential of E7-directed vaccination strategies in mice tumour models. In the present study, we tested the immunogenicity of a fusion protein (PD-E7) comprising a mutated HPV-16 E7 linked to the first 108 amino acids of Haemophilus influenzae protein D, formulated in the GlaxoSmithKline Biologicals adjuvant AS02B, in patients bearing oncogenic HPV-positive cervical intraepithelial neoplasia (CIN). Methods: Seven patients, five with a CIN3 and two with a CIN1, received three intramuscular injections of adjuvanted PD-E7 at 2-week intervals. Three additional CIN1 patients received a placebo. CIN3 patients underwent conization 8 weeks postvaccination. Cytokine flow cytometry and ELISA were used to monitor antigen-specific cellular and antibody responses from blood taken before and after vaccine or placebo injection. Results: Some patients had preexisting systemic IFN-gamma CD4(+) (1/10) and CD8(+) (5/10) responses to PD-E7. Vaccination, not placebo injection, elicited systemic specific immune responses in the majority of the patients. Five vaccinated patients (71%) showed significantly increased IFN-gamma CD8(+) cell responses upon PD-E7 stimulation. Two responding patients generated long-term T-cell immunity toward the vaccine antigen and E7 as well as a weak H. influenzae protein D (PD)-directed CD4(+) response. All the vaccinated patients, but not the placebo, made significant E7- and PD-specific IgG. Conclusions: The encouraging results obtained from this study performed on a limited number of subjects justify further analysis of the efficacy of the PD-E7/AS02B vaccine in CIN patients. [less ▲]

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See detailY a-t-il une ritualité initiatique et des rites de passage pour les adolescents de nos sociétés occidentales contemporaines?
Stassart, Martine ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (2004), 42

All societies are concerned on a highest point with getting over from childhood to adulthood. The socalled primitive people solved that problem through ritual initiation which is identically organized by ... [more ▼]

All societies are concerned on a highest point with getting over from childhood to adulthood. The socalled primitive people solved that problem through ritual initiation which is identically organized by the various "primitive" cultures. Is there an equivalent of that process in the modern western culture? [less ▲]

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See detailReduction of apoptosis and proliferation in endometriosis
Beliard, Aude ULg; Noël, Agnès ULg; Foidart, Jean-Michel ULg

in Fertility and Sterility (2004), 82(1), 80-85

Objective: To evaluate whether endometriosis could be related to an impaired balance between apoptosis and proliferation, two processes which could be modulated by hormonal status. Design ... [more ▼]

Objective: To evaluate whether endometriosis could be related to an impaired balance between apoptosis and proliferation, two processes which could be modulated by hormonal status. Design: Immunohistochemical study. Setting: Academic research laboratory. Intervention(s): Endometriotic samples obtained from peritoneum of women aged 26-40 years who were undergoing laparoscopy for pain or infertility. Main Outcome Measure(s): Apoptotic cells were detected with the use of the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay. The production of p53 and bcl-2, estrogen and Progesterone (P) receptors, and cellular proliferation were assessed by immunohistochemistry in eutopic and ectopic endometria from 30 patients with endometriosis throughout the menstrual cycle. Results were compared with those from normal endometria from 15 fertile patients. Result(s): Endometriotic lesions were characterized by reduced TUNEL and p53 stainings and by enhanced bcl-2 staining. No correlation between apoptosis and estrogen receptor or P receptor levels was found. A lower amount of steroid receptor was found in endometriotic tissues, without cyclic modulation, compared with the eutopic endometrium. Conclusion(s): Our results suggest that when endometrial tissue is located at ectopic locations, it differs from eutopic endometrium by its proliferation rate, steroid hormone levels, and markers of apoptosis. A reduced sensitivity of endometriotic cells to apoptosis could promote the dissemination and implantation of these cells to ectopic sites. (C) 2004 by American Society for Reproductive Medicine. [less ▲]

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See detailEstrogens and pain : a study in aromatase knock-out mice using the formalin model
Multon, Sylvie ULg; Mosen, Jeanine; Wouters, Murielle ULg et al

Poster (2004, July)

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See detailTime dependent risk of gastrointestinal complications induced by non-steroidal anti-inflammatory drug use: a consensus statement using a meta-analytic approach
Richy, F.; Bruyère, Olivier ULg; Ethgen, Olivier ULg et al

in Annals of the Rheumatic Diseases (2004), 63(7), 759-766

OBJECTIVES: To provide an updated document assessing the global, NSAID-specific, and time dependent risk of gastrointestinal (GI) complications through meta-analyses of high quality studies. METHODS: An ... [more ▼]

OBJECTIVES: To provide an updated document assessing the global, NSAID-specific, and time dependent risk of gastrointestinal (GI) complications through meta-analyses of high quality studies. METHODS: An exhaustive systematic search was performed. Inclusion criteria were: RCT or controlled study, duration of 5 days at least, inactive control, assessment of minor or major NSAID adverse effects, publication range January 1985 to January 2003. The publications retrieved were assessed during a specifically dedicated WHO meeting including leading experts in all related fields. Statistics were performed conservatively. Meta-regression was performed by regressing NSAID adjusted estimates against study duration categories. RESULTS: Among RCT data, indolic derivates provided a significantly higher risk of GI complications related to NSAID use than for non-users: RR = 2.25 (1.00; 5.08) than did other compounds: naproxen: RR = 1.83 (1.25; 2.68); diclofenac: RR = 1.73 (1.21; 2.46); piroxicam: RR = 1.66 (1.14; 2.44); tenoxicam: RR = 1.43 (0.40; 5.14); meloxicam: RR = 1.24 (0.98; 1.56), and ibuprofen: RR = 1.19 (0.93; 1.54). Indometacin users had a maximum relative risk for complication at 14 days. The other compounds presented a better profile, with a maximum risk at 50 days. Significant additional risk factors included age, dose, and underlying disease. The controlled cohort studies provided higher estimates: RR = 2.22 (1.7; 2.9). Publication bias testing was significant, towards a selective publication of deleterious effects of NSAIDs from small sized studies. CONCLUSION: This meta-analysis characterised the "compound" and "time" aspects of the GI toxicity of non-selective NSAIDs. The risk/benefit ratio of such compounds should thus be carefully and individually evaluated at the start of long term treatment. [less ▲]

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See detailLes stations de pompage du bassin liégeois, un patrimoine architectural méconnu
Charlier, Sébastien ULg

in Nouvelles du Patrimoine (Les) (2004), 105

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See detailAnti-IgE: a significant breakthrough in the treatment of airway allergic diseases
Louis, Renaud ULg

in Allergy (2004), 59(7), 698-700

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See detailAllogeneic stem cell transplantation in acute lymphoblastic leukemia and non-Hodgkin's lymphoma for patients <= 50 years old in first complete remission: results of the EORTC ALL-3 trial
Labar, Boris; Suciu, Stefan; Zittoun, Robert et al

in Haematologica (2004), 89(7), 809-817

Background and Objectives. In the EORTC ALL-3 trial, the efficacy of allogeneic transplantation was compared with that of autologous marrow transplantation and maintenance chemotherapy in patients less ... [more ▼]

Background and Objectives. In the EORTC ALL-3 trial, the efficacy of allogeneic transplantation was compared with that of autologous marrow transplantation and maintenance chemotherapy in patients less than or equal to 50 years who reached CR. Design and Methods. Among 340 patients who entered the study, 279 were less than or equal to 50 years old. Out of these, 220 reached CR, 184 patients started consolidation and were HLA typed; 68 had a donor and 116 had no sibling donor. The median follow-up was 9.5 years; 93 patients relapsed, 26 died in CR, and overall 116 patients died. Allogeneic transplantation was performed in 47 (68%) patients with a donor while autologous transplantation or maintenance chemotherapy was given to 84 (72%) patients without a sibling donor. Results. The 6-year disease-free survival rate was similar in the groups with and without donor [38.2% (SE=5.9%) vs. 36.8% (SE=4.6%), hazard ratio 1.01, 95% CI 0.67-1.53]. Comparing the donor group with the no donor group, the former had a lower relapse incidence (38.2% vs. 56.3%, p=0.001), but a higher cumulative incidence of death in CR (23.5% vs. 6.9%, p=0.0004). The 6-year survival rates were similar [41.2% (SE=6.0%) vs. 38.8% (SE=4.6%)]. Interpretation and Conclusions. This trial did not show that allogeneic transplantation, when a sibling donor is available, produces a better outcome than the policy of offering autotransplantation or chemotherapy in the absence of a donor. [less ▲]

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See detailCaspases, the enemy within, and their role in oxidative stress-induced apoptosis of inner ear sensory cells
Van De Water, T. R.; Lallemend, François; Eshraghi, A. A. et al

in Otology & Neurotology (2004), 25(4), 627-632

This review covers the general roles of members of the cysteine protease family of caspases in the process of apoptosis (programmed cell death) looking at their participation in both the "extrinsic" cell ... [more ▼]

This review covers the general roles of members of the cysteine protease family of caspases in the process of apoptosis (programmed cell death) looking at their participation in both the "extrinsic" cell death receptor and the "intrinsic" mitochondrial cell death pathways. It defines the difference between initiator and effector caspases and shows the progression of caspase activations that ends up in the apoptotic cell death and elimination of a damaged cell. The review then presents what is currently know about the participation of caspases in the programmed cell death of inner ear sensory cells during the process of normal development and maturation of the inner ear and their importance in this process as illustrated by the results of caspase-3 gene knockout experiments. The participation of specific caspases and the sequence of their activation in the elimination (apoptosis) of damaged sensory cells from adult inner ears after an injury that generates oxidative stress are reviewed. Both the possibility and the potential efficacy of caspase inhibition with a broad-spectrum pancaspase inhibitor as an interventional therapy to treat and rescue oxidative stress-damaged inner ear sensory cells from apoptosis are presented and discussed. [less ▲]

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See detailEndovascular stent-graft for thoracic aorta aneurysm caused by Salmonella
Kotzampassakis, Nicos; Delanaye, Pierre ULg; Masy, François et al

in European Journal of Cardio - Thoracic Surgery (2004), 26(1), 225-227

We describe the placement of an endovascular stent-graft in a patient with mycotic aneurysm of the descending thoracic aorta caused by Salmonella. Endovascular grafting combined with antibiotic therapy in ... [more ▼]

We describe the placement of an endovascular stent-graft in a patient with mycotic aneurysm of the descending thoracic aorta caused by Salmonella. Endovascular grafting combined with antibiotic therapy in thoracic mycotic aneurysms might represent an alternative to conventional surgery in patients with high operative risk. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailThe ponA gene of Enterococcus faecalis JH2-2 codes for a low-affinity class a penicillin-binding protein
Duez, Colette ULg; Hallut, Séverine; Rhazi, Noureddine ULg et al

in Journal of Bacteriology (2004), 186(13), 4412-4416

soluble derivative of the Enterococcus faecalis JH2-2 class A PBP1 (*PBP1) was overproduced and purified. It exhibited a glycosyltransferase activity on the Escherichia coli (14)C(-)labeled lipid 11 ... [more ▼]

soluble derivative of the Enterococcus faecalis JH2-2 class A PBP1 (*PBP1) was overproduced and purified. It exhibited a glycosyltransferase activity on the Escherichia coli (14)C(-)labeled lipid 11 precursor. As a DD-peptidase, it could hydrolyze thiolester substrates with efficiencies similar to those of other class A penicillin-binding proteins (PBPs) and bind beta-lactams, but with k(2)/K (a parameter accounting for the acylation step efficiency) values characteristic of penicillin-resistant PBPs. [less ▲]

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See detailUpdate of the standard numbering scheme for class B beta-lactamases
Garau, G.; Garcia-Saez, I.; Bebrone, Carine ULg et al

in Antimicrobial Agents and Chemotherapy (2004), 48(7), 2347-2349

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See detailWake-Induced Vibration in Power Transmission Line. Parametric study
Lilien, Jean-Louis ULg; Snegovski, Dmitri

in Flow Induced Vibration - FIV 2004 (2004, July)

The paper discusses some aspects of modeling the wake-induced vibrations of the bundle conductors in transmission lines. The wake coupling between subconductors is modeled with the modified Simpson’s ... [more ▼]

The paper discusses some aspects of modeling the wake-induced vibrations of the bundle conductors in transmission lines. The wake coupling between subconductors is modeled with the modified Simpson’s approach. In order to apply this model to the analysis of power transmission line (PTL), a modal representation of a span could be used. In present paper we study how application of Dynamic Reduction (Component Mode) technique may improve such analysis under finite-element approach. The present paper, to extent of authors’ knowledge, is the first where Component Mode method application is discussed to study the subspan oscillation. Finally, bundled conductors’ susceptibility to wake-induced vibrations is illustrated on an exemplary twin-bundle, three-subspan model. Effects of bundle parameters (initial subconductor spacing, frequency ratio, subconductor mass), and the means to account them when applying the component mode method are discussed. [less ▲]

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See detailSystem optimization for residential SOFC 5 kW heat and electricity management
Lilien, Jean-Louis ULg; Lerson, Sébastien; Pochet, Nicolas

(2004, July)

A demonstration project will be presented using a 5 kW Solid Oxyde Fuel Cell for residential application in the region of Liège, Belgium. The current stage of the project is to evaluate the thermal ... [more ▼]

A demonstration project will be presented using a 5 kW Solid Oxyde Fuel Cell for residential application in the region of Liège, Belgium. The current stage of the project is to evaluate the thermal management of a single house with, at the present time, 45 MW.h (thermal 25 MW.h, electrical 20 MW.h) annual consumptions. The changes needed from a classical gas boiler heating of 20 kW to a 6 kW (thermal) plus 5 kW (electrical) system will be studied and detailed. Evaluation of CO2 reduction in the two systems will be presented considering the Belgium mix of electricity production. The heat and electricity local storage to cover peak demand in both energy demands will be discussed in relation with a grid-connected fuel cell. In particular the detailed analysis of this home demand will be analysed for the last three years. An original thermal circuit will be proposed, including its regulation. The experimental result of the behaviour of our proposal during 2003-2004 winter will be presented using a “virtual” SOFC (actually replaced by “equivalent” 6 kWth boiler) which is intended to be used in the same environment after this testing period. Constrains related to SOFC typical behaviour will be taken into account in our proposal for regulation. Depending on our development, it may be possible that up-to-date results may be given at the conference with a real system using a true SOFC 5 kW which would be in service after Septembre 2004. [less ▲]

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See detailMolecular targeting of antiangiogenic factor 16K hPRL inhibits oxygen-induced retinopathy in mice
Pan, H.; Nguyen, Ngoc-Quynh-Nhu ULg; Yoshida, H. et al

in Investigative Ophthalmology & Visual Science (2004), 45(7), 2413-2419

PURPOSE. To examine the ability and mechanism of the 16 kDa N-terminal fragment of human prolactin (16K hPRL) in the inhibition of abnormal retinal neovascularization. METHODS. The 16K hPRL-encoding ... [more ▼]

PURPOSE. To examine the ability and mechanism of the 16 kDa N-terminal fragment of human prolactin (16K hPRL) in the inhibition of abnormal retinal neovascularization. METHODS. The 16K hPRL-encoding sequence was inserted into an adenoviral vector (16K-Ad). Western blot analysis verified the expression of 16K hPRL and inhibition of proliferation, confirming functional activity of the 16K hPRL in virus-infected adult bovine aortic endothelial (ABAE) cells. 16K hPRL inhibited retinal neovascularization in a mouse model of oxygen-induced retinopathy. The ability of recombinant 16K hPRL expressed in E. coli (r16K hPRL) was compared to that of endostatin in inducing apoptosis of cultured human retinal endothelial cells (HREC). RESULTS. 16K was expressed in virus-infected ABAE cells and resulted in a dose-dependent inhibition of cell proliferation. Eyes injected with 16K-Ad showed a reduction in preretinal neovascularization of 82.3 +/- 9.3% (P < 0.00001) when compared to uninjected controls. r16K hPRL was 100 times more potent than endostatin in inducing apoptosis in HRECs. CONCLUSIONS. Intravitreal administration of 16K hPRL inhibited neovascularization in the mouse model of oxygen-induced retinopathy. 16K hPRL stimulated apoptosis in HRECs and inhibited cell proliferation in ABAE cells. These results suggested a potential therapeutic role for 16K hPRL in the treatment of proliferative retinopathies. [less ▲]

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See detailMetabolomic analysis of Strychnos nux-vomica, Strychnos icaja and Strychnos ignatii extracts by H-1 nuclear magnetic resonance spectrometry and multivariate analysis techniques
Frederich, Michel ULg; Choi, Young Hae; Angenot, Luc ULg et al

in Phytochemistry (2004), 65(13), 1993-2001

H-1 Nuclear magnetic resonance spectrometry and multivariate analysis techniques were applied for the metabolic profiling of three Strychnos species: Strychnos nux-vomica (seeds, stem bark, root bark ... [more ▼]

H-1 Nuclear magnetic resonance spectrometry and multivariate analysis techniques were applied for the metabolic profiling of three Strychnos species: Strychnos nux-vomica (seeds, stem bark, root bark), Strychnos ignatii (seeds), and Strychnos icaja (leaves, stem bark, root bark, collar bark). The principal component analysis (PCA) of the H-1 NMR spectra showed a clear discrimination between all samples, using the three first components. The key compounds responsible for the discrimination were brucine, loganin, fatty acids.. and Strychnos icaja alkaloids such as icajine and sungucine. The method was then applied to the classification of several "false angostura" samples. These samples were, as expected, identified as S. nux-vomica by PCA, but could not be clearly discriminated as root bark or stem bark samples after further statistical analysis. (C) 2004 Published by Elsevier Ltd. [less ▲]

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See detailContinuous dynamical systems that realize discrete optimization on the hypercube
Absil, P.-A.; Sepulchre, Rodolphe ULg

in Systems & Control Letters (2004), 52(3-4), 297-304

We study the problem of finding a local minimum of a multilinear function E over the discrete set {0, 1}(n). The search is achieved by a gradient-like system in [0, 1](n) with cost function E. Under mild ... [more ▼]

We study the problem of finding a local minimum of a multilinear function E over the discrete set {0, 1}(n). The search is achieved by a gradient-like system in [0, 1](n) with cost function E. Under mild restrictions on the metric, the stable attractors of the gradient-like system are shown to produce solutions of the problem, even when they are not in the vicinity of the discrete set {0, 1}(n). Moreover, the gradient-like system connects with interior point methods for linear programming and with the analog neural network studied by Vidyasagar (IEEE Trans. Automat. Control 40 (8) (1995) 1359), in the same context. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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