Publications ORBi OA
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See detailMaladie du greffon contre l'hôte chronique : une prise en charge multidisciplinaire
Servais, Sophie ULg; Willems, Evelyne ULg; Beguin, Yves ULg et al

in Revue Médicale de Liège (2010), 65

Chronic Graft-Versus-Host-Disease (GVHD) is a frequent complication of allogeneic hematopoietic cell transplantation. This review article describes recent advances in the classification and treatment of ... [more ▼]

Chronic Graft-Versus-Host-Disease (GVHD) is a frequent complication of allogeneic hematopoietic cell transplantation. This review article describes recent advances in the classification and treatment of chronic GVHD. [less ▲]

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See detailMolecular Reclassification of Crohn's Disease by Cluster Analysis of Genetic Variants
Cleynen, Isabelle; Mahachie John, Jestinah ULg; Henckaerts, Liesbet et al

in PLoS ONE (2010), 5(9), 12952

<sec> <title>Background</title> <p>Crohn's Disease (CD) has a heterogeneous presentation, and is typically classified according to extent and location of disease. The genetic susceptibility to CD is well ... [more ▼]

<sec> <title>Background</title> <p>Crohn's Disease (CD) has a heterogeneous presentation, and is typically classified according to extent and location of disease. The genetic susceptibility to CD is well known and genome-wide association scans (GWAS) and meta-analysis thereof have identified over 30 susceptibility loci. Except for the association between ileal CD and <italic>NOD2</italic> mutations, efforts in trying to link CD genetics to clinical subphenotypes have not been very successful. We hypothesized that the large number of confirmed genetic variants enables (better) classification of CD patients.</p> </sec><sec> <title>Methodology/Principal Findings</title> <p>To look for genetic-based subgroups, genotyping results of 46 SNPs identified from CD GWAS were analyzed by Latent Class Analysis (LCA) in CD patients and in healthy controls. Six genetic-based subgroups were identified in CD patients, which were significantly different from the five subgroups found in healthy controls. The identified CD-specific clusters are therefore likely to contribute to disease behavior. We then looked at whether we could relate the genetic-based subgroups to the currently used clinical parameters. Although modest differences in prevalence of disease location and behavior could be observed among the CD clusters, Random Forest analysis showed that patients could not be allocated to one of the 6 genetic-based subgroups based on the typically used clinical parameters alone. This points to a poor relationship between the genetic-based subgroups and the used clinical subphenotypes.</p> </sec><sec> <title>Conclusions/Significance</title> <p>This approach serves as a first step to reclassify Crohn's disease. The used technique can be applied to other common complex diseases as well, and will help to complete patient characterization, in order to evolve towards personalized medicine.</p> </sec> [less ▲]

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See detailSpectrométrie de masse MALDI-TOF en bactériologie clinique ou comment identifier une bactérie en une minute
MEEX, Cécile ULg

in Spectrométrie de masse MALDI-TOF en bactériologie clinique ou comment identifier une bactérie en une minute (2010)

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See detailLe lymphome du manteau
Jaspers, Aurélie ULg; Baron, Frédéric ULg; Bonnet, Christophe ULg et al

in Revue Médicale de Liège (2010), 65

Mantle cell lymphoma comprises 3 to 10% of non-Hodgkin's lymphomas. Cyclin D1 expression due to t(11;14) (q13;32) is considered as a hallmark of this lymphoma and plays a pivotal role in the ... [more ▼]

Mantle cell lymphoma comprises 3 to 10% of non-Hodgkin's lymphomas. Cyclin D1 expression due to t(11;14) (q13;32) is considered as a hallmark of this lymphoma and plays a pivotal role in the pathophysiology of lymphoma transformation. Median age at diagnosis ranges from 60 to 70 years, and diagnosis is often made at an advances stage with widespread lymphadenopathy and extranodular (particularly bone marrow and gastrointestinal) infiltration. First line treatment consists of combination chemotherapy followed with autologous hematopoietic cell transplantation (HCT) in younger patients, while allogeneic HCT following non-myeloablative conditioning might have a role inpatients relapsing after autologous HCT. [less ▲]

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See detailBreakthrough in the Human Decision Making Based on an Unconscious Origin of Free Will
Dubois, Daniel ULg

in Acta Systemica (2010), X(1), 13-18

This paper deals with a breakthrough in the concept of free will in the human decision making. It is assumed that the consciousness and unconsciousness show the same mind processes in the human brain. The ... [more ▼]

This paper deals with a breakthrough in the concept of free will in the human decision making. It is assumed that the consciousness and unconsciousness show the same mind processes in the human brain. The decision making initiates unconsciously in the human brain, and, eventually, becomes a conscious decision. So the free will is unconsciously prepared in the human brain. Then I conjecture that what is called the conscious human brain is just the enlightening of some parts of the unconscious human brain. [less ▲]

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See detailRapport d'étude : radiographie des étudiants inscrits au 1er bachelier de la catégorie pédagogique de la HEBP
Danse, Cédric ULg

Report (2010)

Rapport de recherche portant sur les facteurs de motivation et d'accrochage scolaire en lien avec la réussite.

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See detailRetour sur les romans du 11 septembre
Delville, Michel ULg

Article for general public (2010)

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See detailFuselage structure optimization
Grihon, Stéphane; Samuelides, Manuel; Merval, Arnaud et al

in Kesseler, Ernst; Guenov, Martin (Eds.) Advances in Collaborative Civil Aeronautical Multidisciplinary Optimization (2010)

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See detailDylan Thomas en chansons
Delville, Michel ULg

Article for general public (2010)

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See detailAntonio Lobo Antunes
Delville, Michel ULg

in Culture, le magazine culturel de l'Université de Liège (2010)

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See detailQuality of mixing in a stirred bioreactor used for animal cells culture: heterogeneities in a lab scale bioreactor and evolution of mixing time with scale up
Collignon, Marie-Laure ULg; Dossin, Denis; Delafosse, Angélique ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2010), 14

Animal cells are industrially cultivated inside stirred bioreactors to produce proteinic compounds. Due to the use of mild agitation conditions in order to limit mechanical constraints, the homogeneity of ... [more ▼]

Animal cells are industrially cultivated inside stirred bioreactors to produce proteinic compounds. Due to the use of mild agitation conditions in order to limit mechanical constraints, the homogeneity of the culture medium can be far from perfect. This study has therefore two objectives. 1) the global characterization of the mixing via the mixing time 2) the local description of concentration fields. The mixing time is measured by conductimetry inside 20 L, 80 L, 600L tanks. The Grenville correlation is adjusted on these experimental measurements to improve the prediction of the mixing time during the scale-up of the process. The concentration fields are visualized by the Planar Laser Induced Fluorescence (P.L.I.F) technique in the 20 L tank. This part of the study is focused on the time evolution of the maximum value of the tracer concentration inside measurement planes and of the numerical distribution of theses concentration fields. [less ▲]

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See detailManifestes!
Delville, Michel ULg

Article for general public (2010)

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See detailImproved modelling of helium and tritium production for spallation targets
Leray, S.; Boudard, A.; Cugnon, Joseph ULg et al

in Nuclear Instruments & Methods in Physics Research. Section B, Beam Interactions with Materials and Atoms (2010), 268(6), 581-586

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See detailRaccontare Zeus. Poesia e cultura di corte ad Alessandria, a partire dall’Inno I di Callimaco
Caneva, Stefano ULg

in Pallas : Revue d'Etudes Antiques (2010), 83

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See detailCanguilhem, Erwin Straus et la phénoménologie : la question de l'organisame vivant
Gérard, Marie ULg

in Bulletin D'Analyse (2010), 6(2), 118-145

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See detailThymic self-antigens for the design of a negative/tolerogenic self-vaccination against type 1 diabetes.
Geenen, Vincent ULg; Mottet, Marie ULg; Dardenne, Olivier ULg et al

in Current Opinion in Pharmacology (2010), 10

Before being able to react against infectious non-self antigens, the immune system has to be educated in the recognition and tolerance of neuroendocrine proteins and this critical process takes place only ... [more ▼]

Before being able to react against infectious non-self antigens, the immune system has to be educated in the recognition and tolerance of neuroendocrine proteins and this critical process takes place only in the thymus. The development of the autoimmune diabetogenic response results from a thymus dysfunction in programming central self-tolerance to pancreatic insulin-secreting islet β cells, leading to the breakdown of immune homeostasis with an enrichment of islet β-cell reactive effector T cells and a deficiency of β-cell specific natural regulatory T cells (nTregs) in the peripheral T-lymphocyte repertoire. Insulin-like growth factor 2 (IGF-2) is the dominant member of the insulin family expressed during fetal life by the thymic epithelium under the control of the autoimmune regulator (AIRE) gene/protein. The very low degree of insulin gene transcription in normal murine and human thymus explains why the insulin protein is poorly tolerogenic as evidenced in many studies, including the failure of all clinical trials that have attempted immune tolerance to islet β cells via various methods of insulin administration. Based on the close homology and cross-tolerance between insulin, the primary T1D autoantigen, and IGF-2, the dominant self-antigen of the insulin family, a novel type of vaccination, so-called “negative/tolerogenic self-vaccination”, is currently being developed for prevention and cure of T1D. If this approach were found to be effective for reprogramming immunological tolerance in T1D, it could pave the way for the design of other self-vaccines against autoimmune endocrine diseases, as well as other organ-specific autoimmune diseases. [less ▲]

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