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See detailRaconter la recherche-intervention, retour sur trois opérations de gestion de la biodiversité
Petit, S.; Fleury, P.; Michel, V. et al

in Natures Sciences Sociétés (2008), 16

L'article se fonde sur un matériau peu courant : des récits de projets de gestion de la biodiversité associant les mondes de l'agriculture et de l'environnement. Trois situations de recherche-intervention ... [more ▼]

L'article se fonde sur un matériau peu courant : des récits de projets de gestion de la biodiversité associant les mondes de l'agriculture et de l'environnement. Trois situations de recherche-intervention sont ainsi analysées grâce aux concepts de la science en action. Elles mettent en évidence les caractéristiques de ces collectifs, les connaissances qu'ils mobilisent, ainsi que les outils d'intervention qu'ils construisent dans des processus mêlant recherche et action. La biodiversité dont il est question ici n'est ni celle du ministère dont les collectifs constitués autour de questions inédites se donnent la charge. En les suivant, grâce aux récits qu'en font les chercheurs, nous analysons les ressorts de la recherche-intervention, comparativement à une recherche plus classique. [less ▲]

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See detailContributions of a 3D numerical environment for architectural sketches.
Mayeur, A.; Darses, F.; Leclercq, Pierre ULg

in Lecture Notes in Computer Science (2008)

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See detailAntitumor and anti-angiogenic effects of aplidin in the 5T33MM model, syngeneic model of multiple myeloma
Caers, Jo ULg; De Raeve, Hendrik; Lepage, Doreen et al

in British Journal of Cancer (2008), 98(12), 1966-74

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See detailSystemic resistance and lipoxygenase-related defence response induced in tomato by Pseudomonas putida strain BTP1.
Akram, Adam; Ongena, MARC ULg; Duby, Franceline et al

in BMC Plant Biology (2008), 8

BACKGROUND: Previous studies showed the ability of Pseudomonas putida strain BTP1 to promote induced systemic resistance (ISR) in different host plants. Since ISR is long-lasting and not conducive for ... [more ▼]

BACKGROUND: Previous studies showed the ability of Pseudomonas putida strain BTP1 to promote induced systemic resistance (ISR) in different host plants. Since ISR is long-lasting and not conducive for development of resistance of the targeted pathogen, this phenomenon can take part of disease control strategies. However, in spite of the numerous examples of ISR induced by PGPR in plants, only a few biochemical studies have associated the protective effect with specific host metabolic changes. RESULTS: In this study, we showed the protective effect of this bacterium in tomato against Botrytis cinerea. Following treatment by P. putida BTP1, analyses of acid-hydrolyzed leaf extracts showed an accumulation of antifungal material after pathogen infection. The fungitoxic compounds thus mainly accumulate as conjugates from which active aglycones may be liberated through the activity of hydrolytic enzymes. These results suggest that strain BTP1 can elicit systemic phytoalexin accumulation in tomato as one defence mechanism. On another hand, we have shown that key enzymes of the lipoxygenase pathway are stimulated in plants treated with the bacteria as compared with control plants. Interestingly, this stimulation is observed only after pathogen challenge in agreement with the priming concept almost invariably associated with the ISR phenomenon. CONCLUSION: Through the demonstration of phytoalexin accumulation and LOX pathway stimulation in tomato, this work provides new insights into the diversity of defence mechanisms that are inducible by non-pathogenic bacteria in the context of ISR. [less ▲]

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See detailIncola est. About European Citizenship
Carlier, Jean-Yves ULg

in Böcker, Anita; Havinga, Terry; van de Put, Annie (Eds.) et al Migratierecht en rechtssociologie, gebundeld in Kees' studies, Migration Law and Sociology of Law, collected essays in honour of Kees Groenendijk (2008)

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See detailValidation of x-ray microfocus computed tomography as an imaging tool for porous structures.
Kerckhofs, Greet ULg; Schrooten, J.; Van Cleynenbreugel, T. et al

in The Review of scientific instruments (2008), 79(1), 013711

X-ray microfocus computed tomography (micro-CT) is recently put forward to qualitatively and quantitatively characterize the internal structure of porous materials. However, it is known that artifacts ... [more ▼]

X-ray microfocus computed tomography (micro-CT) is recently put forward to qualitatively and quantitatively characterize the internal structure of porous materials. However, it is known that artifacts such as the partial volume effect are inherently present in micro-CT images, thus resulting in a visualization error with respect to reality. This study proposes a validation protocol that in the future can be used to quantify this error for porous structures in general by matching micro-CT tomograms to microscopic sections. One of the innovations of the protocol is the opportunity to reconstruct an interpolated micro-CT image under the same angle as the physical cutting angle of the microscopic sections. Also, a novel thresholding method is developed based on matching micro-CT and microscopic images. In this study, titanium porous structures are assessed as proof of principle. It is concluded for these structures that micro-CT visualizes 89% of the total amount of voxels (solid and pore) correctly. However, 8% represents an overestimation of the real structure and 3% are real structural features not visualized by micro-CT. When exclusively focusing on the solid fraction in both the micro-CT and microscopic images, only an overestimation of about 5% is found. [less ▲]

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See detailSecuritizing Moves To Nowhere? The Framing of the European Union’s Energy Policy
Natorski, Michal ULg; Herranz-Surrallés, Anna

in Journal of Contemporary European Research (2008), 4(2), 71-89

In 2006, debates about ‘energy security’ reached the top of the EU’s political agenda. A conjunction of political and economic factors seemed to be critically affecting the security of supply in most EU ... [more ▼]

In 2006, debates about ‘energy security’ reached the top of the EU’s political agenda. A conjunction of political and economic factors seemed to be critically affecting the security of supply in most EU member states. A wide range of actors called for the establishment of a ‘Common Energy Policy,’ based on a fully operational Internal Energy Market and equipped with an external dimension enabling the EU to speak with one voice in the world. The results of this heated debate, however, fell short of these objectives. Informed by securitisation approaches, this article explores the debate over energy security that unfolded between 2005 and 2007. It aims to provide an understanding about why the framing of energy as a security issue did not mobilise enough support in favour of ground-breaking measures to tackle what was unanimously presented as a unique and especially hazardous situation. Specifically, the article will argue that those attempts to frame energy as a security issue in order to gain support for a Common Energy Policy have been of limited effect, precisely because the security framing contributed to the further legitimisation of EU member states’ reluctance to cede sovereignty in the energy domain. [less ▲]

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See detailAn original adaptation of photosynthesis in the marine green alga Ostreococcus.
Cardol, Pierre ULg; Bailleul, Benjamin; Rappaport, Fabrice et al

in Proceedings of the National Academy of Sciences of the United States of America (2008), 105(22), 7881-6

Adaptation of photosynthesis in marine environment has been examined in two strains of the green, picoeukaryote Ostreococcus: OTH95, a surface/high-light strain, and RCC809, a deep-sea/low-light strain ... [more ▼]

Adaptation of photosynthesis in marine environment has been examined in two strains of the green, picoeukaryote Ostreococcus: OTH95, a surface/high-light strain, and RCC809, a deep-sea/low-light strain. Differences between the two strains include changes in the light-harvesting capacity, which is lower in OTH95, and in the photoprotection capacity, which is enhanced in OTH95. Furthermore, RCC809 has a reduced maximum rate of O(2) evolution, which is limited by its decreased photosystem I (PSI) level, a possible adaptation to Fe limitation in the open oceans. This decrease is, however, accompanied by a substantial rerouting of the electron flow to establish an H(2)O-to-H(2)O cycle, involving PSII and a potential plastid plastoquinol terminal oxidase. This pathway bypasses electron transfer through the cytochrome b(6)f complex and allows the pumping of "extra" protons into the thylakoid lumen. By promoting the generation of a large DeltapH, it facilitates ATP synthesis and nonphotochemical quenching when RCC809 cells are exposed to excess excitation energy. We propose that the diversion of electrons to oxygen downstream of PSII, but before PSI, reflects a common and compulsory strategy in marine phytoplankton to bypass the constraints imposed by light and/or nutrient limitation and allow successful colonization of the open-ocean marine environment. [less ▲]

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See detailSpontaneous emission from a two-level atom tunneling in a double-well potential
Braun, Daniel; Martin, John ULg

in Physical Review. A (2008), 77

We study a two-level atom in a double-well potential coupled to a continuum of electromagnetic modes (black-body radiation in three dimensions at zero absolute temperature). Internal and external degrees ... [more ▼]

We study a two-level atom in a double-well potential coupled to a continuum of electromagnetic modes (black-body radiation in three dimensions at zero absolute temperature). Internal and external degrees of freedom of the atom couple due to recoil during emission of a photon. We provide a full analysis of the problem in the long wavelengths limit up to the border of the Lamb-Dicke regime, including a study of the internal dynamics of the atom (spontaneous emission), the tunneling motion, and the electric field of the emitted photon. The tunneling process itself may or may not decohere depending on the wavelength corresponding to the internal transition compared to the distance between the two wells of the external potential, as well as on the spontaneous emission rate compared to the tunneling frequency. Interference fringes appear in the emitted light from a tunneling atom, or an atom in a stationary coherent superposition of its center-of-mass motion, if the wavelength is comparable to the well separation, but only if the external state of the atom is post selected. [less ▲]

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See detailPromesses du politique. Aux fondements de l’agir responsable
Nachi, Mohamed ULg

in Ben Achour, Yadh (Ed.) Droits et culture. Mélanges en l’honneur du Doyen Yadh Ben Achour (2008)

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See detailComparison of the tests chosen for material parameter identification to predict single point incremental forming forces
Bouffioux, Chantal ULg; Henrard, Christophe ULg; Eyckens, P. et al

in Asnafi, Nader (Ed.) Proceedings of the International Conference of International Deep Drawing Research Group (IDDRG 2008) (2008)

Single Point Incremental Forming is a sheet forming process that uses a smooth-ended tool following a specific tool path and thus eliminates the need for dedicated die sets. Using this method, the ... [more ▼]

Single Point Incremental Forming is a sheet forming process that uses a smooth-ended tool following a specific tool path and thus eliminates the need for dedicated die sets. Using this method, the material can reach a very high deformation level. A wide variety of shapes can be obtained without specific and costly equipment. To be able to optimize the process, a model and its material parameters are required. The inverse method has been used to provide material data by modeling experiments directly performed on a SPIF set-up and comparing them to the experimental measurements. The tests chosen for this study can generate heterogeneous stress and strain fields. They are performed with the production machine itself and are appropriate for the inverse method since their simulation times are not too high. [less ▲]

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See detailIRM interventionnelle : vers une neuronavigation en temps réel.
Martin, Didier ULg; Nguyen Khac, Minh-Tuan ULg; Scholtes, Félix ULg et al

in Revue Médicale de Liège (2008), 63

La neuronavigation est un outil neurochirurgical qui peut être comparé au GPS. Elle sert à guider la procédure neurochirurgicale en visualisant les déplacements des instruments chirurgicaux sur les images ... [more ▼]

La neuronavigation est un outil neurochirurgical qui peut être comparé au GPS. Elle sert à guider la procédure neurochirurgicale en visualisant les déplacements des instruments chirurgicaux sur les images préopératoires. En augmentant la précision du geste, elle permet d’atteindre des lésions parfois très petites ou difficiles d’accès tout en réduisant la morbidité et en augmentant l’efficacité. Elle présente cependant un écueil majeur. L’image utilisée par le système de navigation est obtenue avant l’intervention et ne peut être corrigée durant celle-ci. En raison des modifications anatomiques inhérentes à l’opération (modification du volume du liquide céphalo-rachidien, résection de la tumeur,…), il apparaît progressivement une discordance entre la réalité chirurgicale et l’imagerie. Les informations pertinentes se périment ainsi peu à peu et la précision se perd. L’IRM interventionnelle est le moyen de réactualiser la neuronavigation par des images de haute définition. De plus, elle permet de réaliser des contrôles intra-opératoires de la qualité du geste chirurgical. [less ▲]

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See detailLINK BETWEEN MARINE MAMMAL EXPOSURE TO PERFLUOROOCTANE SULFONATE (PFOS) AND STABLE-CARBON ISOTOPE RATIOS IN NERITIC AND OCEANIC WATERS OFF BRAZIL
Dorneles, Paulo; Lailson-Brito, José; Meyer, Johan et al

in Organohalogen Compounds (2008), 70

The main objective of the present study was to determine the current concentrations of PFOS in dolphins from neritic and oceanic waters of a region of high industrialization and urbanization in the ... [more ▼]

The main objective of the present study was to determine the current concentrations of PFOS in dolphins from neritic and oceanic waters of a region of high industrialization and urbanization in the Southern Hemisphere. Since stable carbon isotopes can be used to point out relative contributions to the diet of different potential primary sources in trophic networks, indicating for example the inshore versus offshore contribution to food intake 7,8, stable carbon isotope measurements were carried out in the same dolphins in order to clarify inter-species differences. [less ▲]

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See detailMucormycose invasive du poumon et du rachis dorsal.
De Pasqual, Aurelie ULg; Deprez, Manuel ULg; Ghaye, Benoît ULg et al

in Revue Médicale de Liège (2008), 63

Nous rapportons le cas d'un patient de 67 ans atteint d'un syndrome myélodysplasique et qui a développé une mucormycose pulmonaire avec extension tout à fait exceptionnelle vers le rachis dorsal ... [more ▼]

Nous rapportons le cas d'un patient de 67 ans atteint d'un syndrome myélodysplasique et qui a développé une mucormycose pulmonaire avec extension tout à fait exceptionnelle vers le rachis dorsal responsable d'un paraplégie aiguë. Après échec d'un traitement probabiliste anti-aspergillaire, c'est finalement l'analyse des prélèvements obtenus lors de la laminectomie décompressive qui a fourni le diagnostic mycologique. En raison d'une altération majeure de l'état général, la lobectomie prévue n'a pu être réalisée et malgré l'adaptation du traitement antifongique (Abelcet, Posaconazole), le patient est décédé. La mucormycose (ou zygomycose) pulmonaire est une infection fongique peu commune qui touche essentiellement les patients immuno-déprimés. Le champignon pathogène fait partie des zygomycètes dont la caractéristique principale est la capacité d'angio-invasion. L'invasion périneurale est une autre voie de propagation récemment mise en évidence. Les difficultés thérapeutiques associées à cette pathologie sont liées au terrain d'immunodépression, aux difficultés d'obtenir rapidement un diagnostic précis ainsi qu'à l'absence de sensibilité du Mucor aux antifongiques récemment introduits (V-Fend, Cancidas). Ceci souligne le risque inhérent à un traitement antifongique empirique par ces agents et la nécessité d'un prélèvement biopsique précoce en cas de non-réponse au traitement. [less ▲]

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See detailLes glioblastomes, un exemple de recherche translationnelle?
Kroonen, Jérôme ULg; Nguyen-Khac, Minh-Tuan ULg; Deprez, Manuel ULg et al

in Revue Médicale de Liège (2008), 63(5-6), 251-6

Among patients which develop glioblastoma multiform (GBM), recurrence is the rule despite continuous progress in surgery, radiotherapy and chemotherapy. In the adult, GBM is the most frequent and most ... [more ▼]

Among patients which develop glioblastoma multiform (GBM), recurrence is the rule despite continuous progress in surgery, radiotherapy and chemotherapy. In the adult, GBM is the most frequent and most aggressive tumour of the Central Nervous System. A better understanding of the mechanisms by which these tumours relapse could promote the use of preventive therapy and could increase patients' survival. GBM stem cells have been recently described and it was demonstrated that they are specifically implied in the experimental tumorigenesis. It is thus very attractive to speculate on a possible relationship between these GBM stem cells and the neural stem cells which are persisting in the neurogenic zones of the adult brain. In this review, we formulate and discuss the hypothesis by which, in a patient with GBM, malignant stem cells might be present in the neurogenic zones, away from the tumour mass. This hypothesis could explain the tumour relapse observed after the first treatments. [less ▲]

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See detailLes dynamiques économiques et les choix de localisation des entreprises et des services
Merenne-Schoumaker, Bernadette ULg

in Territoire(s) Wallon(s) (2008), juin 2008(Hors série), 57-62

Short answers to the four questions of the workshop 2 1° What role can or should minicipalities play in the new choices for locating manufacturing and service firms? 2° What tools do they have at their ... [more ▼]

Short answers to the four questions of the workshop 2 1° What role can or should minicipalities play in the new choices for locating manufacturing and service firms? 2° What tools do they have at their disposal? 3° How can the municipal options be brought in line with those of neighbouring municipalities in the same life area? 4° And how can the Walloon Region's options for town and country planning and development be integrated in the municipal choices? [less ▲]

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See detailAdaptive remeshing for incremental forming simulation
Lequesne, Cédric ULg; Henrard, Christophe ULg; Bouffioux, Chantal ULg et al

in Pavel, H. (Ed.) Proceedings of the 7th International Conference and Workshop on Numerical Simulation od 3D Sheet Metal Forming Processes (NUMISHEET 2008) (2008)

Incremental forming of aluminium sheets has been modelled by finite element simulations. However the computation time was prohibitive because the tool deforms every part of the sheet and the mesh along ... [more ▼]

Incremental forming of aluminium sheets has been modelled by finite element simulations. However the computation time was prohibitive because the tool deforms every part of the sheet and the mesh along the tool path must be very fine. Therefore, an adaptive remeshing method has been developed. The elements that are close to the tool are divided into smaller elements in order to have a fine mesh where high deformations occur. Consequently, some new nodes become inconsistent with the non-refined neighbouring elements. To overcome that problem, their displacements are constrained, i.e. dependent on their master nodes displacements. The data concerning these new nodes and elements are stored in a linked list, which is a fundamental data structure. It consists of a sequence of cells, each containing data fields and a pointer towards the next cell. The goal of this article is to explain the developments performed in the finite element code, to validate the adaptive remeshing technique and to measure its efficiency using the line test simulation. During this test, which is a simple incremental forming test, a clamped sheet is deformed by a spherical tool moving along a linear path. [less ▲]

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See detailCharacterization of the proneural gene regulatory network during mouse telencephalon development.
Gohlke, Julia M; Armant, Olivier; Parham, Frederick M et al

in BMC Biology (2008), 6

BACKGROUND: The proneural proteins Mash1 and Ngn2 are key cell autonomous regulators of neurogenesis in the mammalian central nervous system, yet little is known about the molecular pathways regulated by ... [more ▼]

BACKGROUND: The proneural proteins Mash1 and Ngn2 are key cell autonomous regulators of neurogenesis in the mammalian central nervous system, yet little is known about the molecular pathways regulated by these transcription factors. RESULTS: Here we identify the downstream effectors of proneural genes in the telencephalon using a genomic approach to analyze the transcriptome of mice that are either lacking or overexpressing proneural genes. Novel targets of Ngn2 and/or Mash1 were identified, such as members of the Notch and Wnt pathways, and proteins involved in adhesion and signal transduction. Next, we searched the non-coding sequence surrounding the predicted proneural downstream effector genes for evolutionarily conserved transcription factor binding sites associated with newly defined consensus binding sites for Ngn2 and Mash1. This allowed us to identify potential novel co-factors and co-regulators for proneural proteins, including Creb, Tcf/Lef, Pou-domain containing transcription factors, Sox9, and Mef2a. Finally, a gene regulatory network was delineated using a novel Bayesian-based algorithm that can incorporate information from diverse datasets. CONCLUSION: Together, these data shed light on the molecular pathways regulated by proneural genes and demonstrate that the integration of experimentation with bioinformatics can guide both hypothesis testing and hypothesis generation. [less ▲]

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See detailL’entreprise virtuelle
Choffray, Jean-Marie ULg

in Ordre des Experts-Comptables Français (Ed.) Entreprise 2018 (2008)

Dans notre société de convenance, il y a tant de thèmes que l’on ne peut se permettre d’évoquer, qu’il est difficile de savoir par lequel ne pas commencer. A la réflexion, la question que posa, à l’issue ... [more ▼]

Dans notre société de convenance, il y a tant de thèmes que l’on ne peut se permettre d’évoquer, qu’il est difficile de savoir par lequel ne pas commencer. A la réflexion, la question que posa, à l’issue d’un séminaire récent, le dirigeant d’un grand groupe industriel, semble constituer un bon sujet à éviter : pour exister, une entreprise doit-elle "exister" ? [less ▲]

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See detailMultivessel coronary revascularization in patients with and without diabetes mellitus: 3-year follow-up of the ARTS-II (Arterial Revascularization Therapies Study-Part II) trial.
Daemen, Joost; Kuck, Karl Heinz; Macaya, Carlos et al

in Journal of the American College of Cardiology (2008), 52(24), 1957-67

OBJECTIVES: The purpose of this study was to assess the 3-year outcome of coronary artery bypass graft surgery (CABG) and percutaneous coronary intervention (PCI) using sirolimus-eluting stents (SES) in ... [more ▼]

OBJECTIVES: The purpose of this study was to assess the 3-year outcome of coronary artery bypass graft surgery (CABG) and percutaneous coronary intervention (PCI) using sirolimus-eluting stents (SES) in patients who had multivessel coronary artery disease with and without diabetes mellitus. BACKGROUND: The optimal method of revascularization in diabetic patients remains in dispute. METHODS: The ARTS-II (Arterial Revascularization Therapies Study-Part II) trial is a single-arm study (n = 607) that included 159 diabetic patients treated with SES whose 3-year clinical outcome was compared with that of the historical diabetic and nondiabetic arms of the randomized ARTS-I trial (n = 1,205, including 96 diabetic patients in the CABG arm and 112 in the PCI arm). RESULTS: At 3 years, among nondiabetic patients, the incidence of the primary composite of death, CVA, myocardial infarction (MI), and repeat revascularization (major adverse cardiac and cerebrovascular events [MACCE]), was significantly lower in ARTS-II than in ARTS-I PCI (adjusted odds ratio [OR]: 0.41; 95% confidence interval [CI]: 0.26 to 0.64) and similar to ARTS-I CABG. The ARTS-II patients were at significantly lower risk for death, CVA, and MI as compared with both the ARTS-I PCI (adjusted OR: 0.55; 95% CI: 0.34 to 0.91) and ARTS-I CABG patients (adjusted OR: 0.56; 95% CI: 0.35 to 0.92). Among diabetic patients, the incidence of MACCE in ARTS-II was similar to that of both PCI and CABG in ARTS-I. Conversely, the incidence of death, CVA, and MI was significantly lower in ARTS-II than in ARTS-I PCI (adjusted OR: 0.67; 95% CI: 0.27 to 1.65) and was similar to that of ARTS-I CABG. CONCLUSIONS: At 3 years, PCI using SES for patients with multivessel coronary artery disease seems to be safer and more efficacious than PCI using bare-metal stents, irrespective of the diabetic status of the patient. Hence, PCI using SES appears to be a valuable alternative to CABG for both diabetic and nondiabetic patients. [less ▲]

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