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See detailEvidence for neo-generation of T cells by the thymus after non-myeloablative conditioning.
Castermans, Emilie ULg; Baron, Frédéric ULg; Willems, Evelyne ULg et al

in Haematologica (2008), 93(2), 240-7

BACKGROUND: Background and objective. We investigated immune recovery in 50 patients given either unmanipulated or CD8-depleted allogeneic peripheral blood stem cells after non-myeloablative conditioning ... [more ▼]

BACKGROUND: Background and objective. We investigated immune recovery in 50 patients given either unmanipulated or CD8-depleted allogeneic peripheral blood stem cells after non-myeloablative conditioning. DESIGN AND METHODS: Fifty patients were randomized to receive either CD8-depleted (n=22) or non-manipulated (n=28) peripheral blood stem cells. The median patients age was 57 (range 36-69) years. The conditioning regimen consisted of 2 Gy total body irradiation with or without added fludarabine. Twenty patients received grafts from related donors, 14 from 10/10 HLA-allele matched unrelated donors, and 16 from HLA-mismatched unrelated donors. Graft-versus-host disease pro-phylaxis consisted of mycophenolate mofetil and cyclosporine. Immune recovery during the first year after hematopoietic cell transplantation was assessed by flow cytometry phenotyping, analyses of the diversity of the TCRBV repertoire, and quantification of signal-joint T-cell receptor excision circles (sjTREC). RESULTS: CD8-depletion of the graft reduced the recovery of CD8(+) T-cell counts in the first 6 months following transplantation (p<0.0001) but had no significant impact on the restoration of other T-cell subsets. Both sjTREC concentration and CD3(+) T-cell counts increased significantly between day 100 and 365 (p=0.010 and p=0.0488, respectively) demonstrating neo-production of T cells by the thymus. Factors associated with high sjTREC concentration 1 year after transplantation included an HLA-matched unrelated donor (p=0.029), a high content of T cells in the graft (p=0.002), and the absence of chronic graft-versus-host disease (p<0.0001). CONCLUSIONS: Our data suggest that while immune recovery is mainly driven by peripheral expansion of the graft-contained mature T cells during the first months after non-myeloablative transplantation, T-cell neo-generation by the thymus plays an important role in long term immune reconstitution in transplanted patients. [less ▲]

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See detailL’influence de l’anxiété sur l’excitation sexuelle : Vers une théorie cognitive
Kempeneers, Philippe ULg; Barbier, Valérie

in Sexologies (2008), 17(2), 66-75

For ages, anxiety has been pointed out as the main etiological factor for sexual dysfunction. Since Wolpe, Masters & Johnson and Kaplan, the understanding of the influence of stress on sexual reactions ... [more ▼]

For ages, anxiety has been pointed out as the main etiological factor for sexual dysfunction. Since Wolpe, Masters & Johnson and Kaplan, the understanding of the influence of stress on sexual reactions has greatly evolved. This article retraces the milestones of such an evolution. In two decades, the reciprocal inhibitory theory has been replaced by a theory describing more accurately the complex relationship between anxiety and excitation. The combined development of plethysmography and cognitive psychology has greatly contributed to clarify this relationship. Indeed, the relationship between anxiety and sexual arousal appears more complex than originally recognized. Plethysmography directly measures genital vasocongestion at presentation of erotic stimuli and thus permits an objective assessment of sexual arousal in varied circumstances (erotic, anxiety producing, neutral or distracting). In studies using this paradigm, anxiety appears to have a non linear influence on sexual arousal: sometimes it is inhibitory, other times it is facilitative. Articulating the results obtained using plethysmography with the latest development in cognitive sciences, the following hypothesis came to mind: erotophobia could be considered of factor of vulnerability towards cognitive interference. In a sexual situation, erotophobic subjects focus primarily upon danger related information. This could engender a massive irruption of non erotic cues (non relevant task information) in working memory. Therefore, cognitive function available for sexual arousal would be diminished and sexual activity would be impaired. This hypothesis brings light onto the inhibitory effect of anxiety on sexual arousal among dysfunctional subjects. When this cognitive interference is not present, anxiety rather reinforces sexual arousal: either by increasing the focus of attention towards sexual cues or by misinterpreting the physiological reactions induced by the stressful situation as being sexual in origin. [less ▲]

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See detailRecent progress in the optimal design of composite structures: industrial solution procedures on case studies
Bruyneel, Michaël ULg; Colson, Benoit; Jetteur, Philippe et al

in International Journal of Simulation & Multidisciplinary Design Optimization (2008), 2

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See detailOptimization of aircraft composite panels with non linear finite element analysis and sensitivities
Colson, Benoit; Bruyneel, Michaël ULg; Grihon, Stéphane et al

Article for general public (2008)

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See detailSAMTECH’s Software: from optimisation of very large composite aircrafts to detailed damage in composite structures analysis
Mu, Quanchen; Remouchamps, Alain; Bruyneel, Michaël ULg

in Journal of Materials Engineering (2008), 57

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See detailDiscussion on some convergence problems in buckling optimization
Bruyneel, Michaël ULg; Colson, Benoit; Remouchamps, Alain

in Structural and Multidisciplinary Optimization (2008), 35

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See detailAdvanced capabilities for the simulation of membrane and inflatable space structures using SAMCEF
Jetteur, Philippe; Bruyneel, Michaël ULg

in Onate, Eugenio (Ed.) Textile Composites and Inflatable Structures II (2008)

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See detailAn industrial solution to analyze delamination
Bruyneel, Michaël ULg; Granville, Didier

Article for general public (2008)

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See detailOptimization of laminated composite structures: problems, solution procedures and applications
Bruyneel, Michaël ULg

in Durand, Lucas (Ed.) Composite Materials Research Progress (2008)

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See detailConcentrations of organobrominated compounds of natural and industrial origin in top predators from Brazilian waters
Dorneles, Paulo; Lailson-Brito, José; Covaci, Adrian et al

in Organohalogen Compounds (2008), 70

The main objective of the present study was to determine the current concentrations of organobrominated compounds in odontocete species from a highly industrialized and urbanized region in the Southern ... [more ▼]

The main objective of the present study was to determine the current concentrations of organobrominated compounds in odontocete species from a highly industrialized and urbanized region in the Southern Hemisphere. [less ▲]

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See detailEvolution of the clinical expression of Bluetongue in Belgian cattle during year 2006 vs 2007
Guyot, Hugues ULg; Mauroy, Axel ULg; Rollin, Frédéric ULg et al

Conference (2008)

In August 2006, Belgium notified its first cases of Bluetongue (BT), serotype 8, in cattle and sheep. The disease was also observed at this time in the neighboring countries. The resurgence of BT was ... [more ▼]

In August 2006, Belgium notified its first cases of Bluetongue (BT), serotype 8, in cattle and sheep. The disease was also observed at this time in the neighboring countries. The resurgence of BT was observed in Northern Europe in 2007. The aim of the study was to compare clinical signs of BT observed in 2006 vs 2007 in Belgian cattle. The description of clinical signs was based on the observation of 38 and 39 cows in 2006 and 2007, respectively. BT cases were only included if they were confirmed by one or both laboratory diagnostic tests (competitive ELISA test and/or RT-qPCR). The inventory of clinical signs was made with a standardised clinical form for BT. This form is divided into general, cutaneous, locomotor, digestive, respiratory, neurological and reproductive clinical signs. Case data were summarised to determine changes in clinical presentation of BT between 2006 and 2007. A Fischer’s exact probability test was performed to compare (P<0.05) the frequency of clinical signs between the two years. Regarding general clinical signs, hyperthermia and tiredness were more often observed in 2007, compared to 2006. All clinical signs about skin and annexes were not significantly different between the two years. Locomotor signs such as prostration, incapacity to get up, reluctance to move, lameness and amyotrophy were more frequent in 2007. Loss of appetite, difficulties in grasping feed, salivation and drooling were the digestive signs more often observed in 2007. A purulent nasal discharge was the only respiratory sign more commonly observed in 2007. Apathy, generalised weakness and paresis or paralysis were more often encountered in 2007. The most important changes between the two years concerned reproduction. A higher incidence of abortion, premature calving and stillbirth was observed during 2007 outbreak. The frequency of most of the clinical signs of BT was higher in 2007 in Belgian cattle. Confirmed cases of BT in Belgian cattle were only 296 in 2006 compared to 4187 in 2007. These data do not represent the real situation of BT infection because the farmers do not notify all cases. Nevertheless, it seems that the 2007 outbreak was more severe regarding the number of cases and the frequency of clinical signs. The mild winter and wet 2007 summer might have favored the persistence of the vectors. [less ▲]

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See detailMorphological alterations of zooxanthellae in bleached cnidarian hosts
Ladrière, Ophélie ULg; Compère, Philippe ULg; Decloux, Nicole ULg et al

in Cahiers de Biologie Marine (2008), 49(3), 215-227

Studying the morphological changes of zooxanthellae in the host gastroderm is essential to understand the mechanisms of bleaching. Transmission electron microscopy was used to observe samples from four ... [more ▼]

Studying the morphological changes of zooxanthellae in the host gastroderm is essential to understand the mechanisms of bleaching. Transmission electron microscopy was used to observe samples from four coral species-three collected from a barrier reef in Madagascar (Acropora digitifera (Dana, 1846), Echinopora hirsutissima Milne-Edwards & Haime, 1849 and Porites (Synaraea) rus Forskal, 1775)) and one cut from an aquarium-grown coral (Pocillopora damicornis (Linnaeus, 1758)-and from the hermatypic (zooxanthellae-containing) sea anemone Aiptasia pulchella (Carlgren, 1943). Zooxanthellae from bleached animals showed different stages of degradation or disorganization. Some were free, detached from the host gastroderm, associated or not with host-cell remains. Others were vacuolated, with abundant reserve material globules and angular holes probably created by the loss of crystalline material during cutting. Experimentally heat-shocked P. damicornis harboured, moreover, a greater number of dividing algae. Bleached individuals were found to vary as regards their response to stress, and zooxanthellae expelled from heat-shocked anemones showed a greater mitotic index and a higher survival rate than algae extracted or naturally externalized from healthy individuals. We propose a combination of morphological criteria for use in diagnosing the health state of algae-cnidarian symbiosis, so vulnerable in the case of bleaching. [less ▲]

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See detailSTABILIZATION OF THREE-DIMENSIONAL COLLECTIVE MOTION
Scardovi, Luca; Leonard, N. E.; Sepulchre, Rodolphe ULg

in Communications in Information and Systems (2008), 8(4), 473-500

This paper proposes a methodology to stabilize relative equilibria in a model of identical, steered particles moving in three-dimensional Euclidean space. Exploiting the Lie group structure of the ... [more ▼]

This paper proposes a methodology to stabilize relative equilibria in a model of identical, steered particles moving in three-dimensional Euclidean space. Exploiting the Lie group structure of the resulting dynamical system, the stabilization problem is reduced to a consensus problem on the Lie algebra. The resulting equilibria correspond to parallel, circular and helical formations. We first derive the stabilizing control laws in the presence of all-to-all communication. Providing each agent with a consensus estimator, we then extend the results to a general setting that allows for unidirectional and time-varying communication topologies. [less ▲]

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See detailA Box-Behnken Design For Predicting The Combined Effects Of Relative Humidity And Temperature On Antagonistic Yeast Population Density At The Surface Of Apples
Lahlali, Rachid; Massart, Sébastien ULg; Serrhini, Mn. et al

in International Journal of Food Microbiology (2008), 122(1-2), 100-108

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See detailImprovements of image processing for wheat ear counting
Cointault, Frédéric; Journaux, Ludovic; Miteran, Joel et al

in Agricultural and biosystems engineering for a sustainable world (2008)

One of the most important activity of agricultural research insititutes concerns the agronomical experiments done under different conditions needing many land observations and valuations to quantify ... [more ▼]

One of the most important activity of agricultural research insititutes concerns the agronomical experiments done under different conditions needing many land observations and valuations to quantify several variables. These observations, although generally accurate, are visually done by the agriculturist technicians and present numerous drawbacks: penibility, weak productivity, numerous labor force, limited sampling … Two feasibility studies lead in our laboratory recently have shown that some of the previous observations, and particularly the counting of the number of wheat ear per m², can be done by color and/or texture image processing for images taken directly in the field with a specific acquisition system. This paper describes the improvements of the previous studies concerning the image acquisition system, and especially the illumination control, and the justification of different hypothesis on the number of classes to detect in an image. The use of a cluster validity index has allowed to prove that 3 classes to determine all the objects in a wheat ear image are not sufficient. A correlation with a study based on the size of the analysis window is currently under investigation to improve the ear detection, which is now of 6%, compared to manual counting done by agriculturist technicians. [less ▲]

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See detailDetermination of plant height for weed detection in stereoscopic images
Piron, Alexis ULg; Leemans, Vincent ULg; Kleynen, Olivier et al

in AGENG 2008 Conference - Agricultural & Biosystems Engineering for a Sustainable World (2008)

The aim of this study was twofold. The first goal was to acquire high accuracy stereoscopic images of small-scale field scenes, the second to examine the potential of plant height as a discriminant factor ... [more ▼]

The aim of this study was twofold. The first goal was to acquire high accuracy stereoscopic images of small-scale field scenes, the second to examine the potential of plant height as a discriminant factor between crop and weed, within carrot rows. Emphasis was put on how to determine actual plant height taking into account the variable distance from camera to ground and ground irregularities for in-field measurements. Multispectral stereoscopic images were taken over a period of 19 days starting one week after crop emergence and seven weed species were considered. Images were acquired with a mobile vision system consisting in a filter wheel based multispectral camera and a video projector. The stereoscopy technique used belonged to the coded structured light family. The stereoscopic acquisition method yielded good results despite the numerous stereoscopic difficulties exhibited by the scenes. A plant height parameter as opposed to distance from camera to plant pixels gave better results for classification (classification accuracy of up [less ▲]

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