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See detailAladdin nulling instrument
Barillot, Marc; Coudé Du Foresto, Vincent; Surdej, Jean ULg et al

in Spinoglio, L.; Epchtein, N. (Eds.) 3rd ARENA Conference: An Astronomical Observatory at CONCORDIA (Dome C, Antarctica) (2010)

The ALADDIN project aims at detecting warm dust populations around nearby main sequence stars. In order to achieve the significantly improved sensitivity with respect to existing instruments, the ... [more ▼]

The ALADDIN project aims at detecting warm dust populations around nearby main sequence stars. In order to achieve the significantly improved sensitivity with respect to existing instruments, the architecture of the system is focused and optimised for the mission: ALADDIN implements the nulling interferometry technique at the focal plane of a 2-telescope interferometer mounted on a rotating structural beam. Concerning the beam combining nulling instrument, the ALADDIN design is inherited from a Definition Study of the VLTI/GENIE instrument. In this paper, we demonstrate how the ALADDIN instrument preliminary definition can be made simpler and more representative of a space instrument than GENIE thanks to both the outstanding atmospheric properties of Dome C and the dedicated architecture of the system. Finally, we discuss the compatibility of the instrument with the Antarctic environment and constraints, and underline the experimental and industrial know-how learnt from the MAII and PERSEE nulling breadboards in which our Team is also involved. [less ▲]

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See detailMaternal plasma soluble fms-like tyrosine kinase-1 and free vascular endothelial growth factor at 11 to 13 weeks of gestation in preeclampsia.
Akolekar, R.; De Cruz, J.; Foidart, Jean-Michel ULg et al

in Prenatal Diagnosis (2010), 30(3), 191-7

Objective To investigate the maternal plasma concentration of soluble fms-like tyrosine kinase-1 (sFlt-1) and free vascular endothelial growth factor (free-VEGF) at 11 to 13 weeks of gestation in patients ... [more ▼]

Objective To investigate the maternal plasma concentration of soluble fms-like tyrosine kinase-1 (sFlt-1) and free vascular endothelial growth factor (free-VEGF) at 11 to 13 weeks of gestation in patients destined to develop preeclampsia (PE) and to examine whether any possible differences in maternal plasma levels are related to uterine artery pulsatility index (PI) and maternal serum placental growth factor (PlGF). Methods Plasma free-VEGF, plasma sFlt-1, serum PlGF and uterine artery PI were measured at 11 to 13 weeks in 90 cases that subsequently developed PE and in 180 unaffected controls. Results In the majority of cases of PE and controls the levels of free-VEGF were undetectable. In the pregnancies that developed PE, compared to unaffected controls, uterine artery PI was higher, serum PlGF was lower but there was no significant difference in levels of sFlt-1. Conclusion Measurement of free-VEGF and sFlt-1 in maternal blood at 11 to 13 weeks of gestation is not useful in the prediction of pregnancies destined to develop PE [less ▲]

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See detailEffect of bovine colostrum on the serum insulin-like growth factor-I (IGF-I), the IGF binding proteins-2 and -3 and the thyroid hormones in weaning piglets
Boudry, Christelle ULg; Dehoux, Jean-Paul; Colinet, Frédéric ULg et al

in Archiv Tierzucht (2010), 53(6), 675-688

This study examined the effect of a bovine colostrum supplementation on growth performance, feed intake and the hormonal response of piglets at weaning. Ninety-six newly-weaned piglets were assigned for ... [more ▼]

This study examined the effect of a bovine colostrum supplementation on growth performance, feed intake and the hormonal response of piglets at weaning. Ninety-six newly-weaned piglets were assigned for four weeks to one of the two treatments: Control (diet with bovine milk whey) and Colostrum (diet with bovine colostrum whey) treatments. The supplements were incorporated in a commercial diet at 20 g/kg during the first 2 weeks after weaning and lowered to 10 g/kg for the next 2 weeks. Body weight and feed intake were measured weekly. Blood samples were taken weekly for determination of circulating IGF-I, its binding proteins and the thyroid hormones (T3 and T4). During the first week of the trial, the Colostrum-fed piglets presented improved growth performance, feed intake and feed efficiency and a higher concentration in circulating IGF-I (+ 15 %) compared to the Control piglets. In both treatments, the circulating thyroid hormones were reduced by weaning and the levels measured at weaning were recovered earlier by the Colostrum-fed piglets compared to the Control group (P < 0.05). It is concluded that hormonal response observed after the bovine colostrum supplementation is, at least in part, consequent of the positive action of bovine colostrum on the feed intake. [less ▲]

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See detailRift Valley fever virus seroprevalence in human rural populations of Gabon.
Pourrut, Xavier; Nkoghe Mba, Dieudonne ULg; Souris, Marc et al

in PLoS Neglected Tropical Diseases (2010), 4(7), 763

BACKGROUND: Rift Valley fever (RVF) is a mosquito-borne viral zoonosis caused by a phlebovirus and transmitted by Aedes mosquitoes. Humans can also be infected through direct contact with blood (aerosols ... [more ▼]

BACKGROUND: Rift Valley fever (RVF) is a mosquito-borne viral zoonosis caused by a phlebovirus and transmitted by Aedes mosquitoes. Humans can also be infected through direct contact with blood (aerosols) or tissues (placenta, stillborn) of infected animals. Although severe clinical cases can be observed, infection with RVF virus (RVFV) in humans is, in most cases, asymptomatic or causes a febrile illness without serious symptoms. In small ruminants RVFV mainly causes abortion and neonatal death. The distribution of RVFV has been well documented in many African countries, particularly in the north (Egypt, Sudan), east (Kenya, Tanzania, Somalia), west (Senegal, Mauritania) and south (South Africa), but also in the Indian Ocean (Madagascar, Mayotte) and the Arabian Peninsula. In contrast, the prevalence of RVFV has rarely been investigated in central African countries. METHODOLOGY/PRINCIPAL FINDINGS: We therefore conducted a large serological survey of rural populations in Gabon, involving 4,323 individuals from 212 randomly selected villages (10.3% of all Gabonese villages). RVFV-specific IgG was found in a total of 145 individuals (3.3%) suggesting the wide circulation of Rift Valley fever virus in Gabon. The seroprevalence was significantly higher in the lakes region than in forest and savannas zones, with respective rates of 8.3%, 2.9% and 2.2%. In the lakes region, RVFV-specific IgG was significantly more prevalent in males than in females (respectively 12.8% and 3.8%) and the seroprevalence increased gradually with age in males but not in females. CONCLUSIONS/SIGNIFICANCE: Although RVFV was suggested to circulate at a relatively high level in Gabon, no outbreaks or even isolated cases have been documented in the country. The higher prevalence in the lakes region is likely to be driven by specific ecologic conditions favorable to certain mosquito vector species. Males may be more at risk of infection than females because they spend more time farming and hunting outside the villages, where they may be more exposed to mosquito bites and infected animals. Further investigations are needed to determine the putative sylvan cycle of RVFV, including the mosquito species and the reservoir role of wild animals in the viral maintenance cycle. [less ▲]

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See detailExozodiacal discs with ALADDIN: how faint can we detect them?
Absil, Olivier ULg; Coudé Du Foresto; Barillot, M. et al

in Spinoglio, L.; Epchtein, N. (Eds.) 3rd ARENA Conference: An Astronomical Observatory at CONCORDIA (Dome C, Antarctica) (2010)

In this paper, we describe the expected performance of ALADDIN, a nulling interferometer project optimised for operation at Dome C. After reviewing the main atmospheric parameters pertaining to infrared ... [more ▼]

In this paper, we describe the expected performance of ALADDIN, a nulling interferometer project optimised for operation at Dome C. After reviewing the main atmospheric parameters pertaining to infrared interferometry on the high Antarctic plateau, we shortly describe the ALADDIN instrument and compute its estimated performance in terms of the smallest exozodiacal dust disc density that can be detected. Our estimations are based on a thorough end-to-end software simulator previously developed for the GENIE nulling interferometer project at VLTI. We then propose a possible mission scenario, where the southern target stars of future exo-Earth characterisation missions can be surveyed for the presence of bright exozodiacal discs (>50 zodi) within one winter-over at Concordia. [less ▲]

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See detailREVISED EU-CRITERIA FOR APPLYING BIOANALYTICAL METHODS FOR SCREENING OF FEED AND FOOD FOR DIOXINS AND DIOXIN-LIKE PCBS.
Hoogenboom, LAP; Hadrich, Johan; Eppe, Gauthier ULg et al

in Organohalogen Compounds (2010), 72

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See detailErectile Dysfonction, a Sentinel of Cardiovascular Disease...
Andrianne, Robert ULg; Legros, Jean-Jacques ULg

in Acta Chirurgica Belgica (2010), 110

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See detailPenile Prosthesis in the Age of the Blue Pill
Andrianne, Robert ULg

in Acta Chirurgica Belgica (2010), (110), 149-152

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See detailWhy the EU Merger Regulation should not enjoy a Monopoly over Tacit Collusion
Petit, Nicolas ULg; Henry, David

in Krasnodebska-Tomkiel (Ed.) Changes in Competition policy over the last two Decades (2010)

Over the past two decades, the European Commission (“the Commission”) has adopted a stance whereby the implementation of ex ante, structural merger rules is deemed more appropriate when seeking to ... [more ▼]

Over the past two decades, the European Commission (“the Commission”) has adopted a stance whereby the implementation of ex ante, structural merger rules is deemed more appropriate when seeking to challenge tacit collusion than ex post, behavioural instruments (e.g. on the basis of Article 102 of the Treaty on the Functioning of the EU (“TFEU”). As a result, the EU merger regulation (“EUMR”) is the preferred, if not sole, legal instrument deployed by the Commission in order to avert any potential risk of tacit collusion. Since the entry into force of the EUMR, the number of Commission decisions in which the future emergence of risks of collective dominance was examined lies in the region of 130. In stark contrast, and despite pronouncements of the General Court (“GC”, or the Court) that Article 102 TFEU may apply to tacit collusion, the Commission has not yet taken a single decision enforcing Article 102 TFEU against tacitly collusive oligopolies. Similarly, the stillness of the 2009 Guidance Communication on Enforcement Priorities in applying Article 102 TFEU in this context implicitly confirms the Commission’s reluctance to use the abuse of dominance rules in order to address the phenomenon of tacit collusion. Overall, within the realm of EU competition law, the provisions of the EUMR de facto enjoy a jurisdictional monopoly over issues pertaining to collective dominance. The present article challenges the conventional view that tacit collusion should be exclusively addressed through the use of the EUMR. To this end, it examines and seeks to set straight five widespread misconceptions on which such view is based. [less ▲]

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See detailToxicity at three years with and without irradiation of the internal mammary and medial supraclavicular lymph node chain in stage i to III breast cancer (EORTC trial 22922/10925)
Matzinger, O.; Heimsoth, I.; Poortmans, P. et al

in Acta Oncologica (2010), 49(1), 24-34

Introduction. The EORTC 22922/10925 trial investigated the potential survival benefit and toxicity of elective irradiation of the internal mammary and medial supraclavicular (IM-MS) nodes Accrual ... [more ▼]

Introduction. The EORTC 22922/10925 trial investigated the potential survival benefit and toxicity of elective irradiation of the internal mammary and medial supraclavicular (IM-MS) nodes Accrual completed in January 2004 and first results are expected in 2012. We present the toxicity reported until year 3 after treatment. Patients and methods. At each visit, toxicity was reported but severity was not graded routinely. Toxicity rates and performance status (PS) changes at three years were compared by χ2 tests and logistic regression models in all the 3 866 of 4 004 patients eligible to the trial who received the allocated treatment. Results. Only lung (fibrosis; dyspnoea; pneumonitis; any lung toxicities) (4.3% vs. 1.3%; p < 0.0001) but not cardiac toxicity (0.3% vs. 0.4%; p = 0.55) significantly increased with IM-MS treatment. No significant worsening of the PS was observed (p = 0.79), suggesting that treatment-related toxicity does not impair patient's daily activities. Conclusions. IM-MS irradiation seems well tolerated and does not significantly impair WHO PS at three years. A follow-up period of at least 10 years is needed to determine whether cardiac toxicity is increased after radiotherapy. [less ▲]

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See detailComparison of active and electrostimulated recovery strategies after fatiguing exercise
Vanderthommen, Marc ULg; Makrof, Souleyma; Demoulin, Christophe ULg

in Journal of Sports Science & Medicine (2010), 9

The purpose of this study was to compare an electrostimulated to an active recovery strategy after a submaximal isometric fatiguing exercise. Nineteen healthy men completed three sessions (separated by at ... [more ▼]

The purpose of this study was to compare an electrostimulated to an active recovery strategy after a submaximal isometric fatiguing exercise. Nineteen healthy men completed three sessions (separated by at least 4 weeks) which included a knee extensors provocation exercise consisting of 3 sets of 25 isometric contractions. Contraction intensity level was fixed respectively at 60%, 55% and 50% of previously determined maximal voluntary contraction for the first, second and third sets. This provocation exercise was followed by either an active (AR) recovery (25 min pedaling on a cycle ergometer), an electrostimulated (ESR) recovery (25-min continuous and nontetanic (5 Hz) stimulation of the quadriceps) or a strictly passive recovery (PR). Peak torques of knee extensors and subjective perception of muscle pain (VAS, 0-10) were evaluated before (pre-ex), immediately after the provocation exercise (post-ex), after the recovery period (post-rec), as well as 75 minutes (1h15) and one day (24h) after the exercise bout. Time course of peak torque was similar among the different recovery modes: ~ 75% of initial values at post-ex, ~ 90% at post-rec and at 1h15. At 24h, peak torque reached a level close to baseline values (PR: 99.1 ± 10.7%, AR: 105.3 ± 12.2%, ESR: 104.4 ± 10.5%). VAS muscle pain scores decreased rapidly between post-ex and postrec (p < 0.001); there were no significant differences between the three recovery modes (p = 0.64). In conclusion, following a submaximal isometric knee extension exercise, neither electrostimulated nor active recovery strategies significantly improved the time course of muscle function recovery. [less ▲]

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See detailEducation on sensor-augmented pump use improves glucose control in type-1 diabetic patients.
Thielen, Vinciane ULg; Place, J.; Gerbaud, S. et al

in Diabètes & Métabolism (2010)

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See detailIs the ADA/EASD algorithm for the management of type 2 diabetes (January 2009) based on evidence or opinion? A critical analysis.
Schernthaner, G.; Barnett, A. H.; Betteridge, D. J. et al

in Diabetologia (2010)

The ADA and the EASD recently published a consensus statement for the medical management of hyperglycaemia in patients with type 2 diabetes. The authors advocate initial treatment with metformin ... [more ▼]

The ADA and the EASD recently published a consensus statement for the medical management of hyperglycaemia in patients with type 2 diabetes. The authors advocate initial treatment with metformin monotherapy and lifestyle modification, followed by addition of basal insulin or a sulfonylurea if glycaemic goals are not met (tier 1 recommendations). All other glucose-lowering therapies are relegated to a secondary (tier 2) status and only recommended for selected clinical settings. In our view, this algorithm does not offer physicians and patients the appropriate selection of options to individualise and optimise care with a view to sustained control of blood glucose and reduction both of diabetes complications and cardiovascular risk. This paper critically assesses the basis of the ADA/EASD algorithm and the resulting tiers of treatment options. [less ▲]

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See detailPioglitazone Use in Combination with Insulin in the Prospective Pioglitazone Clinical Trial in Macrovascular Events Study (PROactive19).
Charbonnel, B.; Defronzo, R.; Davidson, J. et al

in Journal of Clinical Endocrinology and Metabolism (2010)

Objective: In this post hoc analysis, we examined insulin requirements and regimens, glycemic control, cardiovascular outcomes, and safety in the patients treated with insulin at baseline in the ... [more ▼]

Objective: In this post hoc analysis, we examined insulin requirements and regimens, glycemic control, cardiovascular outcomes, and safety in the patients treated with insulin at baseline in the Prospective Pioglitazone Clinical Trial in Macrovascular Events study. Design: The Prospective Pioglitazone Clinical Trial in Macrovascular Events study was a double-blind, placebo-controlled outcome study (mean follow-up 34.5 months) in 5238 high-risk patients with type 2 diabetes randomized to pioglitazone (force titrated to 45 mg) or placebo. One third of the total population (pioglitazone 864; placebo 896) were receiving insulin at baseline. Results: A rapid and sustained decrease in insulin dose was observed with pioglitazone vs. a progressive increase with placebo. By study end, the mean insulin dose was lower with pioglitazone (42 vs. 55 U/d with placebo; P < 0.0001). The insulin regimen (number on insulin, need for multiple injections, and reduction in oral agents) had been simplified vs. placebo; nevertheless, a greater glycosylated hemoglobin reduction was observed with pioglitazone (-0.93%) vs. placebo (-0.45%; P < 0.0001). At the final visit, insulin had been discontinued in 9% of pioglitazone vs. 2% of placebo patients (P < 0.0001). More insulin-resistant patients (defined as poorly controlled type 2 diabetes despite high doses of insulin) in the pioglitazone plus insulin group showed the greatest glycosylated hemoglobin decline. There were nonsignificant reductions with pioglitazone relative to placebo in the cardiovascular primary (hazard ratio 0.86; 95% confidence interval 0.71, 1.04; P = 0.1198) and main secondary (hazard ratio 0.85; 95% confidence interval 0.67, 1.08; P = 0.1831) end points in insulin-treated patients. The rates of overall heart failure, edema, and hypoglycemia were higher with pioglitazone [13.5 vs 10.5% (P = 0.0489); 30.8 vs. 18.2% (P < 0.0001); and 42.1 vs 29.0% (P < 0.0001), respectively], but there were no significant differences in serious events. Conclusions: Pioglitazone use in combination with insulin resulted in a sustained improved glycemic control and allowed the treatment regimens to be simplified and the insulin doses reduced. [less ▲]

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See detailExercise-induced changes in degenerative mitral regurgitation
Magne, Julien ULg; Lancellotti, Patrizio ULg; Pierard, Luc ULg

in Journal of the American College of Cardiology (2010), 56(4), 300-309

OBJECTIVES: We sought to quantify exercise-induced changes in patients with degenerative mitral regurgitation (MR), to examine the relationship between exercise-induced changes in MR and in systolic ... [more ▼]

OBJECTIVES: We sought to quantify exercise-induced changes in patients with degenerative mitral regurgitation (MR), to examine the relationship between exercise-induced changes in MR and in systolic pulmonary artery pressure (PAP), and to identify their potential impact on symptom-free survival. BACKGROUND: MR severity can change during exercise in patients with functional MR. Quantified changes in MR severity during exercise remain undetermined in patients with degenerative MR. METHODS: Resting and bicycle exercise Doppler-echocardiography were performed in 61 asymptomatic patients (age 62+/-14 years) with moderate to severe degenerative MR (i.e., mitral valve prolapse or flail). Mitral regurgitation was quantified at rest and exercise with effective regurgitant orifice (ERO) area and regurgitant volume calculated with the proximal isovelocity surface area (EROP) and the quantitative Doppler (EROD) methods. RESULTS: At rest, EROP and EROD were well-correlated (r=0.87, p<0.0001), but EROD was larger than EROP (54+/-21 mm2 vs. 42+/-24 mm2, p<0.0001). During exercise, mean ERO and regurgitant volume markedly increased in 32% of patients by >or=10 mm2 and >or=15 ml, respectively. There was good correlation between exercise EROP and EROD (r=0.84, p<0.0001). Changes in systolic PAP were correlated with changes in ERO and regurgitant volume (r=0.59, p=0.02 and r=0.60, p=0.02). Patients with a marked increase in regurgitant volume during exercise had lower symptom-free survival than those in whom MR decreased or remained unchanged (p=0.0015). CONCLUSIONS: Degenerative MR might be dynamic and increases during exercise in one-third of patients. Marked changes in MR severity are associated with exercise-induced changes in systolic PAP and reduced symptom-free survival. [less ▲]

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See detailEmotion and false memories: affective valence influences participant’s susceptibility to false memories and illusory recollection.
Dehon, Hedwige ULg; Laroi, Frank ULg; Van der Linden, Martial ULg

in Emotion (2010), 10(5), 627-639

This study examined the influence of emotional valence on the production of DRM false memories (Roediger & McDermott, 1995). Participants were presented with neutral, positive or negative DRM lists for a ... [more ▼]

This study examined the influence of emotional valence on the production of DRM false memories (Roediger & McDermott, 1995). Participants were presented with neutral, positive or negative DRM lists for a later recognition (Experiment 1) or recall (Experiment 2) test. In both experiments, confidence and recollective experience (i.e., “Remember-Know” judgements; Tulving, 1985) were also assessed. Results consistently showed that, compared with neutral lists, affective lists induced more false recognition and recall of non presented critical lures. Moreover, although confidence ratings did not differ between the false remembering from the different kinds of lists, “Remember” responses were more often associated with negative than positive and neutral false remembering of the critical lures. In contrast, positive false remembering of the critical lures was more often associated with “Know” responses. These results are discussed in light of the Paradoxical Negative Emotion (PNE) hypothesis (Porter et al., 2008). [less ▲]

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See detailThe HelpED Study: Degree of Agreement Between Patients, Partners, and Physicians on
Claes, Hubert; Andrianne, Robert ULg; Opsomer, Reinier

Poster (2010)

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See detailThe HelpED Study: Impact of Change in Erection Hardness on the Self-Esteem,
Opsomer, Reinier; Claes, Hubert; Andrianne, Robert ULg

Poster (2010)

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See detailProteomic analysis of human pancreas cancers for the identification of targetable biomarkers
Castronovo, Vincenzo ULg; Wang, Ying Hong; Musmeci, Davide et al

(2010)

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See detailL’apport d’une université au développement régional. Le cas de Liège
Merenne-Schoumaker, Bernadette ULg

in Mutations. Mémoires et perspectives du Bassin minier (2010), 2/2010

L’impact d’une université sur son territoire est étudié depuis près de 40 ans, les travaux se focalisant principalement sur les aspects économiques de cet impact et parfois sur la formation, la culture ... [more ▼]

L’impact d’une université sur son territoire est étudié depuis près de 40 ans, les travaux se focalisant principalement sur les aspects économiques de cet impact et parfois sur la formation, la culture, la santé ou encore l’image de marque. L'objectif de cet article est de mettre en évidence succinctement les problématiques et méthodologies de ces travaux, puis d'analyser le cas de l'Université de Liège [less ▲]

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