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See detailEstrogens and pain : a study in aromatase knock-out mice using the formalin model
Multon, Sylvie ULg; Mosen, Jeanine; Wouters, Murielle ULg et al

Poster (2004, July)

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See detailTime dependent risk of gastrointestinal complications induced by non-steroidal anti-inflammatory drug use: a consensus statement using a meta-analytic approach
Richy, F.; Bruyère, Olivier ULg; Ethgen, Olivier ULg et al

in Annals of the Rheumatic Diseases (2004), 63(7), 759-766

OBJECTIVES: To provide an updated document assessing the global, NSAID-specific, and time dependent risk of gastrointestinal (GI) complications through meta-analyses of high quality studies. METHODS: An ... [more ▼]

OBJECTIVES: To provide an updated document assessing the global, NSAID-specific, and time dependent risk of gastrointestinal (GI) complications through meta-analyses of high quality studies. METHODS: An exhaustive systematic search was performed. Inclusion criteria were: RCT or controlled study, duration of 5 days at least, inactive control, assessment of minor or major NSAID adverse effects, publication range January 1985 to January 2003. The publications retrieved were assessed during a specifically dedicated WHO meeting including leading experts in all related fields. Statistics were performed conservatively. Meta-regression was performed by regressing NSAID adjusted estimates against study duration categories. RESULTS: Among RCT data, indolic derivates provided a significantly higher risk of GI complications related to NSAID use than for non-users: RR = 2.25 (1.00; 5.08) than did other compounds: naproxen: RR = 1.83 (1.25; 2.68); diclofenac: RR = 1.73 (1.21; 2.46); piroxicam: RR = 1.66 (1.14; 2.44); tenoxicam: RR = 1.43 (0.40; 5.14); meloxicam: RR = 1.24 (0.98; 1.56), and ibuprofen: RR = 1.19 (0.93; 1.54). Indometacin users had a maximum relative risk for complication at 14 days. The other compounds presented a better profile, with a maximum risk at 50 days. Significant additional risk factors included age, dose, and underlying disease. The controlled cohort studies provided higher estimates: RR = 2.22 (1.7; 2.9). Publication bias testing was significant, towards a selective publication of deleterious effects of NSAIDs from small sized studies. CONCLUSION: This meta-analysis characterised the "compound" and "time" aspects of the GI toxicity of non-selective NSAIDs. The risk/benefit ratio of such compounds should thus be carefully and individually evaluated at the start of long term treatment. [less ▲]

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See detailLes stations de pompage du bassin liégeois, un patrimoine architectural méconnu
Charlier, Sébastien ULg

in Nouvelles du Patrimoine (Les) (2004), 105

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See detailAnti-IgE: a significant breakthrough in the treatment of airway allergic diseases
Louis, Renaud ULg

in Allergy (2004), 59(7), 698-700

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See detailAllogeneic stem cell transplantation in acute lymphoblastic leukemia and non-Hodgkin's lymphoma for patients <= 50 years old in first complete remission: results of the EORTC ALL-3 trial
Labar, Boris; Suciu, Stefan; Zittoun, Robert et al

in Haematologica (2004), 89(7), 809-817

Background and Objectives. In the EORTC ALL-3 trial, the efficacy of allogeneic transplantation was compared with that of autologous marrow transplantation and maintenance chemotherapy in patients less ... [more ▼]

Background and Objectives. In the EORTC ALL-3 trial, the efficacy of allogeneic transplantation was compared with that of autologous marrow transplantation and maintenance chemotherapy in patients less than or equal to 50 years who reached CR. Design and Methods. Among 340 patients who entered the study, 279 were less than or equal to 50 years old. Out of these, 220 reached CR, 184 patients started consolidation and were HLA typed; 68 had a donor and 116 had no sibling donor. The median follow-up was 9.5 years; 93 patients relapsed, 26 died in CR, and overall 116 patients died. Allogeneic transplantation was performed in 47 (68%) patients with a donor while autologous transplantation or maintenance chemotherapy was given to 84 (72%) patients without a sibling donor. Results. The 6-year disease-free survival rate was similar in the groups with and without donor [38.2% (SE=5.9%) vs. 36.8% (SE=4.6%), hazard ratio 1.01, 95% CI 0.67-1.53]. Comparing the donor group with the no donor group, the former had a lower relapse incidence (38.2% vs. 56.3%, p=0.001), but a higher cumulative incidence of death in CR (23.5% vs. 6.9%, p=0.0004). The 6-year survival rates were similar [41.2% (SE=6.0%) vs. 38.8% (SE=4.6%)]. Interpretation and Conclusions. This trial did not show that allogeneic transplantation, when a sibling donor is available, produces a better outcome than the policy of offering autotransplantation or chemotherapy in the absence of a donor. [less ▲]

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See detailCaspases, the enemy within, and their role in oxidative stress-induced apoptosis of inner ear sensory cells
Van De Water, T. R.; Lallemend, François; Eshraghi, A. A. et al

in Otology & Neurotology (2004), 25(4), 627-632

This review covers the general roles of members of the cysteine protease family of caspases in the process of apoptosis (programmed cell death) looking at their participation in both the "extrinsic" cell ... [more ▼]

This review covers the general roles of members of the cysteine protease family of caspases in the process of apoptosis (programmed cell death) looking at their participation in both the "extrinsic" cell death receptor and the "intrinsic" mitochondrial cell death pathways. It defines the difference between initiator and effector caspases and shows the progression of caspase activations that ends up in the apoptotic cell death and elimination of a damaged cell. The review then presents what is currently know about the participation of caspases in the programmed cell death of inner ear sensory cells during the process of normal development and maturation of the inner ear and their importance in this process as illustrated by the results of caspase-3 gene knockout experiments. The participation of specific caspases and the sequence of their activation in the elimination (apoptosis) of damaged sensory cells from adult inner ears after an injury that generates oxidative stress are reviewed. Both the possibility and the potential efficacy of caspase inhibition with a broad-spectrum pancaspase inhibitor as an interventional therapy to treat and rescue oxidative stress-damaged inner ear sensory cells from apoptosis are presented and discussed. [less ▲]

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See detailEndovascular stent-graft for thoracic aorta aneurysm caused by Salmonella
Kotzampassakis, Nicos; Delanaye, Pierre ULg; Masy, François et al

in European Journal of Cardio - Thoracic Surgery (2004), 26(1), 225-227

We describe the placement of an endovascular stent-graft in a patient with mycotic aneurysm of the descending thoracic aorta caused by Salmonella. Endovascular grafting combined with antibiotic therapy in ... [more ▼]

We describe the placement of an endovascular stent-graft in a patient with mycotic aneurysm of the descending thoracic aorta caused by Salmonella. Endovascular grafting combined with antibiotic therapy in thoracic mycotic aneurysms might represent an alternative to conventional surgery in patients with high operative risk. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailThe ponA gene of Enterococcus faecalis JH2-2 codes for a low-affinity class a penicillin-binding protein
Duez, Colette ULg; Hallut, Séverine; Rhazi, Noureddine ULg et al

in Journal of Bacteriology (2004), 186(13), 4412-4416

soluble derivative of the Enterococcus faecalis JH2-2 class A PBP1 (*PBP1) was overproduced and purified. It exhibited a glycosyltransferase activity on the Escherichia coli (14)C(-)labeled lipid 11 ... [more ▼]

soluble derivative of the Enterococcus faecalis JH2-2 class A PBP1 (*PBP1) was overproduced and purified. It exhibited a glycosyltransferase activity on the Escherichia coli (14)C(-)labeled lipid 11 precursor. As a DD-peptidase, it could hydrolyze thiolester substrates with efficiencies similar to those of other class A penicillin-binding proteins (PBPs) and bind beta-lactams, but with k(2)/K (a parameter accounting for the acylation step efficiency) values characteristic of penicillin-resistant PBPs. [less ▲]

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See detailUpdate of the standard numbering scheme for class B beta-lactamases
Garau, G.; Garcia-Saez, I.; Bebrone, Carine ULg et al

in Antimicrobial Agents and Chemotherapy (2004), 48(7), 2347-2349

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See detailWake-Induced Vibration in Power Transmission Line. Parametric study
Lilien, Jean-Louis ULg; Snegovski, Dmitri

in Flow Induced Vibration - FIV 2004 (2004, July)

The paper discusses some aspects of modeling the wake-induced vibrations of the bundle conductors in transmission lines. The wake coupling between subconductors is modeled with the modified Simpson’s ... [more ▼]

The paper discusses some aspects of modeling the wake-induced vibrations of the bundle conductors in transmission lines. The wake coupling between subconductors is modeled with the modified Simpson’s approach. In order to apply this model to the analysis of power transmission line (PTL), a modal representation of a span could be used. In present paper we study how application of Dynamic Reduction (Component Mode) technique may improve such analysis under finite-element approach. The present paper, to extent of authors’ knowledge, is the first where Component Mode method application is discussed to study the subspan oscillation. Finally, bundled conductors’ susceptibility to wake-induced vibrations is illustrated on an exemplary twin-bundle, three-subspan model. Effects of bundle parameters (initial subconductor spacing, frequency ratio, subconductor mass), and the means to account them when applying the component mode method are discussed. [less ▲]

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See detailSystem optimization for residential SOFC 5 kW heat and electricity management
Lilien, Jean-Louis ULg; Lerson, Sébastien; Pochet, Nicolas

(2004, July)

A demonstration project will be presented using a 5 kW Solid Oxyde Fuel Cell for residential application in the region of Liège, Belgium. The current stage of the project is to evaluate the thermal ... [more ▼]

A demonstration project will be presented using a 5 kW Solid Oxyde Fuel Cell for residential application in the region of Liège, Belgium. The current stage of the project is to evaluate the thermal management of a single house with, at the present time, 45 MW.h (thermal 25 MW.h, electrical 20 MW.h) annual consumptions. The changes needed from a classical gas boiler heating of 20 kW to a 6 kW (thermal) plus 5 kW (electrical) system will be studied and detailed. Evaluation of CO2 reduction in the two systems will be presented considering the Belgium mix of electricity production. The heat and electricity local storage to cover peak demand in both energy demands will be discussed in relation with a grid-connected fuel cell. In particular the detailed analysis of this home demand will be analysed for the last three years. An original thermal circuit will be proposed, including its regulation. The experimental result of the behaviour of our proposal during 2003-2004 winter will be presented using a “virtual” SOFC (actually replaced by “equivalent” 6 kWth boiler) which is intended to be used in the same environment after this testing period. Constrains related to SOFC typical behaviour will be taken into account in our proposal for regulation. Depending on our development, it may be possible that up-to-date results may be given at the conference with a real system using a true SOFC 5 kW which would be in service after Septembre 2004. [less ▲]

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See detailMolecular targeting of antiangiogenic factor 16K hPRL inhibits oxygen-induced retinopathy in mice
Pan, H.; Nguyen, Ngoc-Quynh-Nhu ULg; Yoshida, H. et al

in Investigative Ophthalmology & Visual Science (2004), 45(7), 2413-2419

PURPOSE. To examine the ability and mechanism of the 16 kDa N-terminal fragment of human prolactin (16K hPRL) in the inhibition of abnormal retinal neovascularization. METHODS. The 16K hPRL-encoding ... [more ▼]

PURPOSE. To examine the ability and mechanism of the 16 kDa N-terminal fragment of human prolactin (16K hPRL) in the inhibition of abnormal retinal neovascularization. METHODS. The 16K hPRL-encoding sequence was inserted into an adenoviral vector (16K-Ad). Western blot analysis verified the expression of 16K hPRL and inhibition of proliferation, confirming functional activity of the 16K hPRL in virus-infected adult bovine aortic endothelial (ABAE) cells. 16K hPRL inhibited retinal neovascularization in a mouse model of oxygen-induced retinopathy. The ability of recombinant 16K hPRL expressed in E. coli (r16K hPRL) was compared to that of endostatin in inducing apoptosis of cultured human retinal endothelial cells (HREC). RESULTS. 16K was expressed in virus-infected ABAE cells and resulted in a dose-dependent inhibition of cell proliferation. Eyes injected with 16K-Ad showed a reduction in preretinal neovascularization of 82.3 +/- 9.3% (P < 0.00001) when compared to uninjected controls. r16K hPRL was 100 times more potent than endostatin in inducing apoptosis in HRECs. CONCLUSIONS. Intravitreal administration of 16K hPRL inhibited neovascularization in the mouse model of oxygen-induced retinopathy. 16K hPRL stimulated apoptosis in HRECs and inhibited cell proliferation in ABAE cells. These results suggested a potential therapeutic role for 16K hPRL in the treatment of proliferative retinopathies. [less ▲]

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See detailMetabolomic analysis of Strychnos nux-vomica, Strychnos icaja and Strychnos ignatii extracts by H-1 nuclear magnetic resonance spectrometry and multivariate analysis techniques
Frederich, Michel ULg; Choi, Young Hae; Angenot, Luc ULg et al

in Phytochemistry (2004), 65(13), 1993-2001

H-1 Nuclear magnetic resonance spectrometry and multivariate analysis techniques were applied for the metabolic profiling of three Strychnos species: Strychnos nux-vomica (seeds, stem bark, root bark ... [more ▼]

H-1 Nuclear magnetic resonance spectrometry and multivariate analysis techniques were applied for the metabolic profiling of three Strychnos species: Strychnos nux-vomica (seeds, stem bark, root bark), Strychnos ignatii (seeds), and Strychnos icaja (leaves, stem bark, root bark, collar bark). The principal component analysis (PCA) of the H-1 NMR spectra showed a clear discrimination between all samples, using the three first components. The key compounds responsible for the discrimination were brucine, loganin, fatty acids.. and Strychnos icaja alkaloids such as icajine and sungucine. The method was then applied to the classification of several "false angostura" samples. These samples were, as expected, identified as S. nux-vomica by PCA, but could not be clearly discriminated as root bark or stem bark samples after further statistical analysis. (C) 2004 Published by Elsevier Ltd. [less ▲]

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See detailContinuous dynamical systems that realize discrete optimization on the hypercube
Absil, P.-A.; Sepulchre, Rodolphe ULg

in Systems & Control Letters (2004), 52(3-4), 297-304

We study the problem of finding a local minimum of a multilinear function E over the discrete set {0, 1}(n). The search is achieved by a gradient-like system in [0, 1](n) with cost function E. Under mild ... [more ▼]

We study the problem of finding a local minimum of a multilinear function E over the discrete set {0, 1}(n). The search is achieved by a gradient-like system in [0, 1](n) with cost function E. Under mild restrictions on the metric, the stable attractors of the gradient-like system are shown to produce solutions of the problem, even when they are not in the vicinity of the discrete set {0, 1}(n). Moreover, the gradient-like system connects with interior point methods for linear programming and with the analog neural network studied by Vidyasagar (IEEE Trans. Automat. Control 40 (8) (1995) 1359), in the same context. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailCan phonological and semantic short-term memory be dissociated ? Further evidence from Landau-Kleffner syndrome
Majerus, Steve ULg; Van der Linden, Martial ULg; Poncelet, Martine ULg et al

in Cognitive Neuropsychology (2004), 21(5), 491-512

Recent studies have made a distinction between short-term storage capacities for phonological information and short-term storage capacities for lexico-semantic information (R. Martin, Lesch,

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See detailDISSIPATIVITY AND GLOBAL ANALYSIS OF LIMIT CYCLES IN NETWORKS OF OSCILLATORS
Stan, Guy-Bart; Sepulchre, Rodolphe ULg

in Proceedings of the 16th Symposium on Mathematical Theory of Networks and Systems (2004, July)

This paper is concerned with the global analysis of synchrone oscillations in special networks of oscillators. In previous work, we de ned a class of highdimensional, parameter-dependent nonlinear systems ... [more ▼]

This paper is concerned with the global analysis of synchrone oscillations in special networks of oscillators. In previous work, we de ned a class of highdimensional, parameter-dependent nonlinear systems exhibiting almost globally asymptotically stable limit cycle oscillations. In this paper, we show how (incremental) dissipativity may be used to extend the global analysis of limit cycle oscillations to networks of coupled identical systems. [less ▲]

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See detailPreparation method of (co)oligomer or (co)polymer by in-situ polymerization of monoethylenically unsaturated monomer and oligomer or polymer secondary amine to control molecular weight and molecular structure
Detrembleur, Christophe ULg; Rüdiger, Claus; Meyer, Rolf-Volker

Patent (2004)

PURPOSE: Provided is a method for preparing a (co)oligomer or a (co)polymer having a controlled molecular weight, a controlled molecular weight and a narrow polydispersity at a relatively low temperature ... [more ▼]

PURPOSE: Provided is a method for preparing a (co)oligomer or a (co)polymer having a controlled molecular weight, a controlled molecular weight and a narrow polydispersity at a relatively low temperature and for a short time. CONSTITUTION: The method comprises the steps of mixing at least one monoethylenically unsaturated monomer represented by HR1C=CR2R3, at least one oxidant, at least one polymer or oligomer represented by the formula 1, and optionally a free radical initiator; and heating the mixture at a temperature of 0-220 deg.C, wherein R1, R2 and R3 are independently H, a C1-C20 alkyl group, a C1-C20 cycloalkyl group, a C6-C24 aryl group, a halogen atom, a cyano group, a C1-C20 alkyl ester group, a C1-C20 cycloalkyl ester group, a C1-C20 alkylamide group, a C1-C20 cycloalkylamide group, a C6-C24 aryl ester group or a C6-C24 arylamide group; Y is an organic residue based on the monomer corresponding to HR1C=CR2R3; m is an integer of 1-50; n is an integer of 1-300; I1 is an initiator; and R4 and X are a secondary or tertiary carbon atom and are independently selected from the group consisting of a C1-C18 alkyl group, a C2-C18 alkenyl group, a C2-C18 alkynyl group, a C3-C12 cycloalkyl group, a C3-C12 hetero cycloalkyl group or a C6-C24 aryl group unsubstituted or substituted with NO2, a halogen atom, an amino group, a hydroxyl group, a cyano group, a carboxyl group, a ketone group, a C1-C4 alkoxy group, a C1-C4 alkylthio group or a C1-C4 alkylamino group. [less ▲]

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See detailPolymerization method of polymer compound by in situ polymerization of monoethylenically unsaturated monomer and secondary amine
Detrembleur, Christophe ULg; Gross, Thomas; Meyer, Rolf-Volker

Patent (2004)

Provided is a method for preparing a polymer compound selected from the group consisting of an oligomer, a cooligomer, a polymer and a copolymer without using an additional free radical initiator ... [more ▼]

Provided is a method for preparing a polymer compound selected from the group consisting of an oligomer, a cooligomer, a polymer and a copolymer without using an additional free radical initiator. CONSTITUTION: The method comprises the steps of mixing at least one monoethylenically unsaturated monomer represented by HR1C=CR2R3, at least one oxidant and at least one secondary amine represented by the formula 2; and heating the mixture at a polymerization temperature of 0-220 deg.C, wherein R1, R2 and R3 are independently H, a C1-C20 alkyl group, a C1-C20 cycloalkyl group, a C6-C24 aryl group, a halogen atom, a cyano group, a C1-C20 alkyl ester group, a C1-C20 cycloalkyl ester group, a C1-C20 alkylamide group, a C1-C20 cycloalkylamide group, a C6-C24 aryl ester group or a C6-C24 arylamide group; R4 and R5 are independently a C1-C18 alkyl group, a C2-C18 alkenyl group, a C2-C18 alkynyl group, a C3-C12 cycloalkyl group, a C3-C12 hetero cycloalkyl group, a C6-C24 aryl group or a C4-C12 alkanol group; and R4 and R5 can form a C2-C13 hetero cycloalkyl residue containing O, S or N together with a nitrogen atom connecting them, or a polycyclic ring-based or polycyclic heterocycloaliphatic ring-based residue containing O, S or N, and in the each case the carbon atom of the radical next to the nitrogen atom is substituted with two or three additional organic substituents. [less ▲]

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See detailComment faire des élèves des citoyens…pas à trop courte vue ?
Jadoulle, Jean-Louis ULg

Article for general public (2004)

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See detailSitu polymerization of monoethylenically unsaturated monomers with oligomeric or polymeric secondary amines
Detrembleur, Christophe ULg; Rudiger, Claus; Meyer, Rolf-Volker

Patent (2004)

A process for the preparation of (co)oligomers or (co)polymers is disclosed. The process entails first the preparation of a mixture that contains a monoethylenically unsaturated monomer conforming to HR<1 ... [more ▼]

A process for the preparation of (co)oligomers or (co)polymers is disclosed. The process entails first the preparation of a mixture that contains a monoethylenically unsaturated monomer conforming to HR<1>C=CR<2>R<3> (M) an oxidizing agent and at least one polymer or oligomer conforming to formula (I), and an optional free radical initiator and then heating the mixture at a temperature in the range of 0 DEG C. to 220 DEG C. [less ▲]

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