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See detailRole of ADAM and ADAMTS metalloproteinases in airway diseases
Paulissen, Geneviève ULg; Rocks, Natacha ULg; Guéders, Maud ULg et al

in Respiratory Research (2009), 10(1), 127

Lungs are exposed to the outside environment and therefore to toxic and infectious agents or allergens. This may lead to permanent activation of innate immune response elements. A Disintegrin And ... [more ▼]

Lungs are exposed to the outside environment and therefore to toxic and infectious agents or allergens. This may lead to permanent activation of innate immune response elements. A Disintegrin And Metalloproteinases (ADAMs) and ADAMs with Thrombospondin motifs (ADAMTS) are proteinases closely related to Matrix Metalloproteinases (MMPs). These multifaceted molecules bear metalloproteinase and disintegrin domains endowing them with features of both proteinases and adhesion molecules. Proteinases of the ADAM family are associated to various physiological and pathological processes and display a wide spectrum of biological effects encompassing cell fusion, cell adhesion, "shedding process", cleavage of various substrates from the extracellular matrix, growth factors or cytokines... This review will focus on the putative roles of ADAM/ADAMTS proteinases in airway diseases such as asthma and COPD. [less ▲]

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See detailLa décentralisation et les possibilités de développement locales en RDC : l'intégration des économies locales en RDC par l'approche de filières certifiées "équitables" : l'exemple du CDI-Bwamanda
Duquesne, Brigitte ULg; Lebailly, Philippe ULg

in Conférence 25èmes Journées Scientifiques ATM 2009 "Attractivité, gouvernance et développement", 3, 4 et 5 juin 2009 : actes du colloque (2009)

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See detailFarming systems in the sandy area of the Thua Thien Hue Province, Central Vietnam, survey of socio-economic situation and constraints identified by farmers
Pham Khanh, Tu; Hoang Thi Thai, Hoa; Hoang Nghia, Duyet et al

in Improving food crop productivity in the coastal sandy area of the Thua Thien Hue Province Central Vietnam : Vietnam-Belgium interuniversity project 2004-2009 (2009)

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See detailSix notices décrivant des ouvrages ayant trait au voyage
Bauden, Frédéric ULg

in Bruyère, Paul; Marchandisse, Alain (Eds.) Florilège du livre en principauté de Liège du IXe au XVIIIe siècle (2009)

Notice 1: De Mandeville, Johannes. Itinerarius a terra Anglie in partes Hyerosolomitanas et in ulteriores transmarinas, editus primo in lingua gallicana a milite suo auctore, anno incarnationis Dni. 1355 ... [more ▼]

Notice 1: De Mandeville, Johannes. Itinerarius a terra Anglie in partes Hyerosolomitanas et in ulteriores transmarinas, editus primo in lingua gallicana a milite suo auctore, anno incarnationis Dni. 1355, in civitate Leodiensi, et paulo post eadem civitate translatus in hanc formam latinam. Université de Liège, ms. 354 (ff. 13-55). Copié par Goeswin de Susteren du couvent des Croisiers à Huy en 1458. Université de Liège, ms. Wittert 99 (77 ff.). XVe s. De Mandeville, Jean. Voyage, [Lyon, Nicolas Philippe et Marc Reinhart, avant 1483]. Université de Liège, cote XV C 66. In-fol. (250 x 180 mm). Caractères gothiques. 79 ff. Notice 2: Darmont, Lambert. Il Viaggio de Heirusalem de Messere Lamberto D[a]rmont Huyensis nel quale con ordine da conto de tutte le cose viste et osservate da lui in esso viaggio con piu carte di geographia di diversi paese et col ritracto de più terre pincipali. Ms. en partie autographe (?) du XVIe s. Papier filigrané. 175 ff. plus un en tête et un en queue, 270 x 160 mm., 141 p. avec dessins. Bruxelles, Bibliothèque Royale, ms. 21056. Notice 3: Voyage de la saincte cité de Hiérusalem, jointe la description des citez, villes, ports lieux et autres passages. Ensemble les cérémonies des Turcs, avec l’estat de leur empereur, ordre de sa gendarmerie, finances et succès de ses conquestes, etc. Pièça descrits par Bartélémi Georginitz (sic), Hongrois, pélérin dudit voiage, par un long temps esclave en Turquie. Le tout remis en lumière par M. Lambert Darmont Liégeois. A Liége. Par Léonard Streel Imprimeur juré. Aux dépens de Lambert de la Coste, MDC. In-4°, de 62 ff. non ch. Göttingen, Universitätsbibliothek, 8 ITIN I, 2701 ; Paris, BnF, RES-O2F-982, J-6613 (disparu) et 4-H-486 ; Paris, Mazarine, A. 14298 ; Paris, Arsenal, H. 1043. Notice 4: Des habits, mœurs, cérémonies, façons de faire anciennes et modernes du monde. Traicté non moins utile que délectable. Avec les pourtraicts des habits taillés par jean de Glen. Liégeois. Divisé –en deux parties. Partie première : des principales nations, provinces, régions et villes de l’Europe. A Liege. Chez J. de Glen, demeurant en la rue dite Gerarderie, à l’Escu d’or. 1601. In-8°, de 8 ff. lim., 218 ff. ch. (la pagination est défectueuse : les ff. 129 à 168 sont chiffrés 179 à 218) et 13 ff. de table. Avec 104 fig. sur bois. Débute par une épître adressée à Mathias d’Ans et Jacques Libert, bourgmestres de la cité de Liège, datée du 15 juin 1601. Le dernier f. de la table porte, au verso, l’approbation de Jean Chapeauille, vicaire de Liège, datée du 12 juin 1601. Université de Liège, cote R00203A : ex-libris de Bartholomé Van den Kerckhove, 1775. Un autre exemplaire sous la cote XX.74.17. Un ex. à Bruxelles, Bibliothèque Royale. Trois exemplaires à Paris, dont deux à la BnF (catalogue en ligne), un à l’Institut national d’histoire de l’art (12 Res 186). Notice 5: BOUCHER (le P. Jean). Bouquet sacré, composé des plus belles fleurs de la Terre Saincte, par le R. P. Jean Boucher, mineur observantin. Reveu, corrigé, augmenté, et enrichi par l’Autheur d’un excellent discours de la noblesse sur la creation des chevaliers du Sainct Sepulchre. Imprimé au cloistre de Nostre Dame des Anges, léz Liege, par Sœur Marie de la Conception et dedié a son tres-cher Pere Jean Wirix, Maÿeur de Wonck. L’an 1660. 394 ff. plus un de garde et en queue de volume, 204 x 159 mm., papier au filigrane des armes d’Amsterdam. Marque de propriété sur le f. 1r° : Hinrich Ernst, datée de 1707. La reliure est moderne. Bruxelles, Bibliothèque royale, ms. 5157-61. Notice 6: Histoire d’Ali Baba, et de quarante voleurs exterminés par une Esclave. Conte tiré des mille & une Nuit. A Liège, chez Denis de Boubers, Imprimeur-Libraire à l’Homme-Sauvage, rue du Pont. M.DCC.LXXXII. In-12, de 73 p. avec 2 fig. sur bois (p. 1 [page de titre] : un cavalier, p. 3 : vue bucolique avec village). Porte une inscription sur le premier contreplat : « Inconnu à de Theux ». Sur la première garde, note manuscrite de Victor Chauvin : « Victor Chauvin, 1 juin 1907, 1.55 f. ». Reliure cartonnée recouverte de papier marbré. Ulg, cote Chauvin 3A. [less ▲]

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See detailPAI-1 Regulates the Invasive Phenotype in Human Cutaneous Squamous Cell Carcinoma
Freytag, J.; Wilkins-Port, C. E.; Higgins, C. E. et al

in Journal of Oncology Management : The Official Journal of the American College of Oncology Administrators (2009)

The emergence of highly aggressive subtypes of human cutaneous squamous cell carcinoma (SCC) often reflects increased autocrine/paracrine TGF-β synthesis and epidermal growth factor receptor (EGFR ... [more ▼]

The emergence of highly aggressive subtypes of human cutaneous squamous cell carcinoma (SCC) often reflects increased autocrine/paracrine TGF-β synthesis and epidermal growth factor receptor (EGFR) amplification. Cooperative TGF-β/EGFR signaling promotes cell migration and induces expression of both proteases and protease inhibitors that regulate stromal remodeling resulting in the acquisition of an invasive phenotype. In one physiologically relevant model of human cutaneous SCC progression, TGF-β1+EGF stimulation increases the production of several matrix metalloproteinases (MMPs), among the most prominent of which is MMP-10—an MMP known to be elevated in SCC in situ. Activation of stromal plasminogen appears to be critical in triggering downstream MMP activity. Paradoxically, PAI-1, the major physiological inhibitor of plasmin generation, is also upregulated under these conditions and is an early event in progression of incipient epidermal SCC. One testable hypothesis proposes that TGF-β1+EGF-dependent MMP-10 elevation directs focalized matrix remodeling events that promote epithelial cell plasticity and tissue invasion. Increased PAI-1 expression serves to temporally and spatially modulate plasmin-initiated pericellular proteolysis, further facilitating epithelial invasive potential. Defining the complex signaling and transcriptional mechanisms that maintain this delicate balance is critical to developing targeted therapeutics for the treatment of human cutaneous malignancies. [less ▲]

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See detailLes facteurs associés à un allaitement maternel prolongé au-delà de trois mois : une revue de la littérature
Noirhomme-Renard, Florence ULg; Noirhomme, Quentin ULg

in Journal de pédiatrie et de puériculture (2009)

L’Organisation mondiale de la santé (OMS) recommande un allaitement maternel exclusif jusqu’à six mois et un allaitement partiel jusqu’à deux ans ou au-delà. En Europe actuellement, il existe de fortes ... [more ▼]

L’Organisation mondiale de la santé (OMS) recommande un allaitement maternel exclusif jusqu’à six mois et un allaitement partiel jusqu’à deux ans ou au-delà. En Europe actuellement, il existe de fortes disparités de prévalence de l’allaitement selon les pays. L’objectif de cet article est de faire le point sur les facteurs associés à un allaitement maternel prolongé au-delà de trois mois. Les études permettent d’identifier différents niveaux de facteurs qui interagissent, selon un cadre écosystémique incluant la mère et son bébé (microsystème), l’entourage (mésosystème), le système de santé (exosystème) et les politiques de santé (macrosystème). Afin d’atteindre les objectifs recommandés par l’OMS, il est important de mettre en place des actions à tous les niveaux. L’information aux mères doit être renforcée, de même que l’implication des pères et la formation des professionnels de santé. Après la sortie de maternité, il est primordial que les mères présentant des facteurs de risque de sevrage précoce soient soutenues si on veut que l’allaitement se poursuive. [less ▲]

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See detailVEGF-D deficiency in mice does not affect embryonic or postnatal lymphangiogenesis but reduces lymphatic metastasis.
Koch, M.; Dettori, D.; Van Nuffelen, A. et al

in Journal of Pathology (The) (2009), 219(3), 356-364

Vascular endothelial growth factor-D (VEGF-D) is one of the two ligands of the VEGFR-3 receptor on lymphatic endothelial cells. Gene-silencing studies in mice and Xenopus tadpoles recently showed that the ... [more ▼]

Vascular endothelial growth factor-D (VEGF-D) is one of the two ligands of the VEGFR-3 receptor on lymphatic endothelial cells. Gene-silencing studies in mice and Xenopus tadpoles recently showed that the role of endogenous VEGF-D in lymphatic development is moderate. By contrast, exogenous VEGF-D is capable of stimulating lymphangiogenesis. Nonetheless, its endogenous role in pathological conditions remains largely unknown. Hence, we reassessed its role in disease, using Vegf-dnull mice. Vegf-dnull mice were generated that, under physiological conditions, displayed normal embryonic and postnatal lymphangiogenesis and lymphatic remodelling, efficient lymphatic functioning and normal health. Vegf-dnull mice also reponded normally in models of skin wound healing and healing of infarcted myocardium, despite enhanced expression of VEGF-D in these models in wild-type mice. In contrast, Vegf-dnull mice displayed reduced peritumoral lymphangiogenesis and lymph node metastasis in an orthotopic pancreatic tumour model. Together, our data indicate that endogenous VEGF-D in mice is dispensible for lymphangiogenesis during development, in postnatal and adult physiology and in several pathological conditions, but significantly contributes to lymphatic metastasis. [less ▲]

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See detailMagnetic resonance spectroscopy and diffusion tensor imaging in coma survivors: promises and pitfalls.
TSHIBANDA, Luaba ULg; Vanhaudenhuyse, Audrey ULg; Galanaud, Damien et al

in Progress in Brain Research (2009), 177

The status of comatose patient is currently established on the basis of the patient-exhibited behaviors. Clinical assessment is subjective and, in 40% of patients, fails to distinguish vegetative state ... [more ▼]

The status of comatose patient is currently established on the basis of the patient-exhibited behaviors. Clinical assessment is subjective and, in 40% of patients, fails to distinguish vegetative state (VS) from minimally conscious states (MCS). The technologic advances of magnetic resonance imaging (MRI) have dramatically improved our understanding of these altered states of consciousness. The role of neuroimaging in coma survivors has increased beyond the simple evaluation of morphological abnormalities. The development of 1H-MR spectroscopy (MRS) and diffusion tensor imaging (DTI) provide opportunity to evaluate processes that cannot be approached by current morphologic MRI sequences. They offer potentially unique insights into the histopathology of VS and MCS. The MRS is a powerful noninvasive imaging technique that enables the in vivo quantification of certain chemical compound or metabolites as N-acetylaspartate (NAA), Choline (Cho), and Creatine (Cr). These biomarkers explore neuronal integrity (NAA), cell membrane turnover (Cho), and cell energetic function (Cr). DTI is an effective and proved quantitative method for evaluating tissue integrity at microscopic level. It provides information about the microstructure and the architecture of tissues, especially the white matter. Various physical parameters can be extracted from this sequence: the fractional anisotropy (FA), a marker of white matter integrity; mean diffusivity (MD); and the apparent diffusion coefficient (ADC) which can differentiate cytotoxic and vasogenic edema. The most prominent findings with MRS and DTI performed in traumatic brain-injured (TBI) patients in subacute phase are the reduction of the NAA/Cr ratio in posterior pons and the decrease of mean infratentorial and supratentorial FA except in posterior pons that enables to predict unfavorable outcome at 1 year from TBI with up to 86% sensitivity and 97% specificity. This review will focus on the interest of comatose patients MRI multimodal assessment with MRS and DTI. It will emphasize the advantages and pitfalls of these techniques in particular in predicting the coma survivors' outcome. [less ▲]

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See detailRoad Pricing as an Impetus for Environment-Friendly Travel Behavior: Results from a Stated Adaptation Experiment
Janssens, Davy; Cools, Mario ULg; Moons, Elke et al

in Transportation Research Record: Journal of the Transportation Research Board (2009), 2115

An important policy instrument for governments to modify travel behavior and manage the increasing travel demand is the introduction of a congestion pricing system. In this study, the influence of a ... [more ▼]

An important policy instrument for governments to modify travel behavior and manage the increasing travel demand is the introduction of a congestion pricing system. In this study, the influence of a detailed classification of activities is examined to assess likely traveler response to congestion pricing scenarios. Despite the fact that most studies do not differentiate between activity categories, the value of time and in general the space–time properties and constraints of different types of activities vary widely. For this reason, it is of importance to provide sufficient detail and sensitivity in assessing the impact of congestion pricing scenarios. In addition, a first assessment of travelers’ possible multifaceted adaptation patterns is presented. For these purposes, a stated adaptation study was conducted in Flanders, the Dutch-speaking region of Belgium. The experiment was conducted through an interactive stated adaptation survey. In the stated adaptation experiment, respondents could indicate their responses to the congestion pricing scenario. The most prevalent conclusion is that the activity type significantly predetermines the willingness to express a more environment-friendly behavior (i.e., reducing the number of trips, reducing the total distance traveled, switching to more environment-friendly modes). Also, the willingness to show ecological activity-travel behavior (e.g., carpooling and using public transport) in a nonpricing situation is a major differentiator of future behavior in a congestion pricing scenario. [less ▲]

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See detailLocalization of Nopp140 within mammalian cells during interphase and mitosis
Thiry, Marc ULg; Cheutin, Thierry; Lamaye, Françoise et al

Poster (2009)

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See detailResponse of floodplain sedimentation to catchment disturbances in different environments
Notebaert, Bastiaan; Houbrechts, Geoffrey ULg; Verstraeten, Gert et al

Poster (2009)

Holocene floodplain sediments are an important environmental archive, that can be accesed for reconstructing the past landscape dynamics either qualitatively (e.g. palynology) and quantitatively (e.g ... [more ▼]

Holocene floodplain sediments are an important environmental archive, that can be accesed for reconstructing the past landscape dynamics either qualitatively (e.g. palynology) and quantitatively (e.g. sediment budgeting). In this study Holocene alluvial sediment deposition in two contrasting Belgian catchments was quantified and dated: the Lienne (148 km²) in the Ardennes massif and the Dijle (750 km2) in the loess region. These catchments experienced a comparable Holocene climatic variation, but differ in topography and geology with highest relief energy in the Lienne catchment. Land use history also differs with high land use intensities in the Dijle catchment since Roman times, but at least since the Middle Ages there were also large deforestations in the Lienne catchment. Detailed cumulative Holocene sediment deposition was assessed for each catchment using more then 1000 hand augerings. Detailed radiocarbon dating of fluvial deposits was performed in the Dijle catchment, while iron slag was used as a tracer for sediments deposited after 1350 AD in the Lienne catchment. Results show that sediment deposition is much larger in the Dijle catchment (~4.5 Mg ha-1 catchment area) then in the Lienne catchment (~0.2 Mg ha-1 catchment area). Dating results from the Dijle catchment show an increase of sediment deposition in the late Holocene, first starting in the colluvial valleys and later on prograding towards the main valleys. Variations in sedimentation rates can clearly be related to anthropogenous land use pressure, and the majority of the sediments found in colluvial and alluvial valleys were deposited in the last 4000 years, and in many cases even in the last 1000 years. Variations in sediment deposition within the catchment can partially be explained by differences in river valley physical settings (mainly valley slope), while in other cases hill slope sediment delivery (upstream erosion, connectivity between hill slopes and the river system) is the explaining factor. In the Lienne catchment, between 80 and 100% of the sediments present in the main valley were deposited before 1350AD, thus before the main period of forest clearance. On the other hand, about 50% of the Holocene sediment present in a main tributary was deposited after 1537 (local start of iron industry). This difference with the main valley can be explained by a difference in physical settings of the river (valley slope, stream power). These results show that the physical settings of river valleys determine how sensible the river systems are to catchment disturbances. Floodplain deposition is determined by an interplay of hill slope sediment delivery (hill slope erosion and connectivity) and physical settings of the valley itself (valley slope, discharge). As a result, quantification of floodplain deposition alone, cannot be used as a measure for historic soil erosion within a catchment or to determine intensity of human impact on the catchment. [less ▲]

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See detailGuia de practica clinica para la valoracion del riesgo cardiaco preoperatorio y el manejo cardiaco perioperatorio en la cirugia no cardiaca
Poldermans, Don; Bax, Jeroen J.; Boersma, Eric et al

in Revista Española de Cardiología (English version) (2009), 62(12), 14671-146756

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See detailStratification du risque dans la cardiomyopathie hypertrophique.
Crochelet, A. S.; Crochelet, L.; Pierard, Luc ULg

in Revue medicale de Liege (2009), 64(11), 576-80

Hypertrophic cardiomyopathy is of genetic origin, characterized by asymmetric left ventricular hypertrophy and variable clinical presentation. The physiopathology includes diastolic dysfunction and, in ... [more ▼]

Hypertrophic cardiomyopathy is of genetic origin, characterized by asymmetric left ventricular hypertrophy and variable clinical presentation. The physiopathology includes diastolic dysfunction and, in one third of the patients, dynamic left ventricular outflow tract obstruction. Patients are at increased risk of sudden death. Risk stratification in the individual patient is an essential component of management. This article describes the clinical presentation of a patient and his mother and summarizes essential features of the disease and the current recommendations for the prevention of sudden cardiac death. [less ▲]

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See detailL'ingénierie patrimoniale dans les relations franco-belges : perspective de droit international privé belge
Wautelet, Patrick ULg

in Derème, François (Ed.) Ingénierie patrimoniale. Questions particulières dans un contexte franco-belge (2009)

In this paper I review the possibilities offered by private international rules in force both in Belgium and in France for three selected tools of estate planning : the marriage contract, gift and ... [more ▼]

In this paper I review the possibilities offered by private international rules in force both in Belgium and in France for three selected tools of estate planning : the marriage contract, gift and donation and wills. The purpose is to examine how much freedom the legal framework in place in the two countries offers to private individuals. Specific attention is devoted to the issue of recognition in one country of acts (such as marriage contracts) drafted in the other country. [less ▲]

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See detailFemmes et religions du livre
Henneau, Marie-Elisabeth ULg

Article for general public (2009)

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See detailCompte rendu de l'ouvrage de Hermann von Kerssenbrock, Narrative of the Anabaptist madness (éd. Christopher S. Mackay)
Donneau, Olivier ULg

in Revue d'Histoire Ecclésiastique (2009), 104(2), 636-638

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