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See detailMDRD or CKD-EPI study equations for estimating prevalence of stage 3 CKD in epidemiological studies: which difference? Is this difference relevant?
Delanaye, Pierre ULg; Cavalier, Etienne ULg; Mariat, C. et al

in BMC Nephrology (2010), 11(8),

Background: Prevalence of stage 3 chronic kidney disease (CKD) is increasing according to the NHANES study. Prevalence has been calculated using the MDRD study equation for estimating glomerular ... [more ▼]

Background: Prevalence of stage 3 chronic kidney disease (CKD) is increasing according to the NHANES study. Prevalence has been calculated using the MDRD study equation for estimating glomerular filtration rate (GFR). Recently, a new estimator based on creatinine, the CKD-EPI equation, has been proposed which is presumed to better perform in normal GFR ranges. The aim of the study was to measure the difference in prevalence of stage 3 CKD in a population using either the MDRD or the CKD-EPI study equations. Methods: CKDscreening is organized in the Province of Liège, Belgium. On a voluntary basis, people aged between 45 and 75 years are invited to be screened. GFR is estimated by the MDRD study equation and by the "new" CKD-EPI equations. Results: The population screened consisted in 1992 people (47% of men). Mean serum creatinine was 0.86 ± 0.20 mg/dl. The prevalence of stage 3 CKD in this population using the MDRD or the CKD-EPI equations was 11.04 and 7.98%, respectively. The prevalence of stage 3 CKD is significantly higher with the MDRD study equation (p <0,0012). Conclusions: Prevalence of stage 3 CKDvaries strongly following the method used for estimating GFR, MDRD or CKDEPI study equations. Such discrepancies are of importance and must be confirmed and explained by additional studies using GFR measured with a reference method. [less ▲]

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See detailShielding efficiency and E(J) characteristics measured on large melt cast Bi-2212 hollow cylinders in axial magnetic fields
Fagnard, Jean-François ULg; Elschner, Steffen; Bock, Joachim et al

in Superconductor Science and Technology (2010), 23

We show that tubes of melt cast Bi-2212 used as current leads for LTS magnets can also act as efficient magnetic shields. The magnetic screening properties under an axial DC magnetic field are ... [more ▼]

We show that tubes of melt cast Bi-2212 used as current leads for LTS magnets can also act as efficient magnetic shields. The magnetic screening properties under an axial DC magnetic field are characterized at several temperatures below the liquid nitrogen temperature (77 K). Two main shielding properties are studied and compared with those of Bi-2223, a material that has been considered in the past for bulk magnetic shields. The first property is related to the maximum magnetic flux density that can be screened, Blim; it is defined as the applied magnetic flux density below which the field attenuation measured at the centre of the shield exceeds 1000. For a cylinder of Bi-2212 with a wall thickness of 5 mm and a large ratio of length over radius, Blim is evaluated to 1 T at T = 10 K. This value largely exceeds the Blim value measured at the same temperature on similar tubes of Bi-2223. The second shielding property that is characterized is the dependence of Blim with respect to variations of the sweep rate of the applied field, dBapp/dt. This dependence is interpreted in terms of the power law E = Ec(J/Jc)^n and allows us to determine the exponent n of this E(J) characteristics for Bi-2212. The characterization of the magnetic field relaxation involves very small values of the electric field. This gives us the opportunity to experimentally determine the E(J) law in an unexplored region of small electric fields. Combining these results with transport and AC shielding measurements, we construct a piecewise E(J) law that spans over 8 orders of magnitude of the electric field. [less ▲]

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See detailUrinary NGAL: Use of absolute value or ratio to creatinine?
Cavalier, Etienne ULg; Bekaert, Anne-Catherine ULg; Legrand, Delphine ULg et al

in Acta Clinica Belgica (2010), 65-3

Introduction: Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as a promising marker for the detection of acute kidney injury. This marker has been proposed for urinary measurement. However ... [more ▼]

Introduction: Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as a promising marker for the detection of acute kidney injury. This marker has been proposed for urinary measurement. However, in the literature, authors indistinctly use "absolute" value or NGAL to creatinine ratio. Up to now, there are no strong arguments favouring for one. This question is of importance as this marker is sensed to be used only on urine random samples. To find an answer to this very practical matter, one approach could be to compare biological CV(intra-individual variation) of the "absolute" and ratio results. [less ▲]

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See detailQuantitative study of catalytic activity and catalytic deactivation of Fe–Co/Al2O3 catalysts for multi-walled carbon nanotube synthesis by the CCVD process
Pirard, Sophie ULg; Heyen, Georges ULg; Pirard, Jean-Paul ULg

in Applied Catalysis A : General (2010), 382

The catalytic deactivation during multi-walled carbon nanotube (MWNT) synthesis by the CCVD process and the influence of hydrogen on it were quantified. Initial specific reaction rate, relative specific ... [more ▼]

The catalytic deactivation during multi-walled carbon nanotube (MWNT) synthesis by the CCVD process and the influence of hydrogen on it were quantified. Initial specific reaction rate, relative specific productivity and catalytic deactivation were studied. Carbon source was ethylene, and a bimetallic iron–cobalt catalyst supported on alumina was used. The catalytic deactivation was modeled by a decreasing hyperbolic law, reflecting the progressive accumulation of amorphous carbon on active sites. While the initial specific reaction rate was found not to be influenced by hydrogen, catalytic deactivation was found to be modified in the presence of hydrogen, which delayed and slowed down the deactivation by avoiding amorphous carbon deposition, thus leading to a greater relative specific productivity of carbon nanotubes. [less ▲]

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See detailRedistribution of fibrillarin following treatment of human bladder carcinoma cells with aptatone
Jamison, James; Gilloteaux, Jacques; Perlaky, L et al

Poster (2010)

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See detailUn oikèma appelé Erechtheion (Pausanias, I, 26, 5)
Pirenne-Delforge, Vinciane ULg

in Carlier, Pierre; Lerouge-Cohen, Charlotte (Eds.) Paysage et religion en Grèce antique. Mélanges offerts à Madeleine Jost (2010)

A close reading of Pausanias’ visit of the north side of the Athenian Acropolis suggests that the present identification of the Erechtheion, which dates back to the seventeenth century, is highly doubtful ... [more ▼]

A close reading of Pausanias’ visit of the north side of the Athenian Acropolis suggests that the present identification of the Erechtheion, which dates back to the seventeenth century, is highly doubtful, as some very few scholars have concluded during the last three decades. The present analysis addresses the word "oikema" used by Pausanias in his description of the Acropolis, comparing this use with all the other places where it appears in the Periegesis. We may conclude that the asymetrical Ionic temple was completely devoted to Athena Polias. Therefore, the so-called Erechtheion has still to be found. [less ▲]

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See detailCarbon dioxide and methane dynamics in estuaries
Borges, Alberto ULg; Abril, G.

Conference (2010)

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See detailL'émancipation du Conseil de la Concurrence? Note sous la décision du Conseil de la concurrence du 26 mai 2009 dans l'affaire Base/BMB
Petit, Nicolas ULg; Provost, Elise ULg

in Tijdschrift voor Belgische Mededinging [=TBM] = Revue de la Concurrence Belge [=RCB] (2010), (2), 89-101

Enième avatar de la bataille juridique opposant les opérateurs alternatifs de communications électroniques à l’ancien monopole public Belgacom1, la décision commentée constitue une première pour Conseil ... [more ▼]

Enième avatar de la bataille juridique opposant les opérateurs alternatifs de communications électroniques à l’ancien monopole public Belgacom1, la décision commentée constitue une première pour Conseil de la concurrence (« le Conseil ») à plus d’un titre : première condamnation de l’opérateur historique, première caractérisation d’un ciseau tarifaire abusif, première décision infligeant une amende aussi élevée en Belgique. Après des années de carence dans l’application des règles de concurrence au secteur des communications électroniques le Conseil parait vouloir renverser la vapeur. Sonne peut-être – comme nous l’avons écrit précédemment – la « fin de la récréation pour l’opérateur historique ». Il faut sans doute s’en féliciter, la Belgique figurant depuis longtemps parmi les mauvais élèves de l’ouverture à la concurrence des industries de réseaux. [less ▲]

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See detailRisque zoonotique, impact vétérinaire et surveillance des virus influenza A porcins dans le cadre de l'émergence du virus pandémique influenza A/H1N1 (2009)
Cardoen, S.; Thiry, Etienne ULg; Caij, A. B. et al

in Annales de Médecine Vétérinaire (2010), 154(1), 30-47

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See detailCurrent Opinion in Pharmacology, Volume 10, Issue 4, Section Immunomodulation
Geenen, Vincent ULg

in Current Opinion in Pharmacology (2010), 10(Issue 4), 405-504

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See detailProlonged ex vivo culture of human bone marrow mesenchymal stem cells influences their supportive activity toward NOD/SCID -repopulating cells and committed progenitor cells of B lymphoid and myeloid lineages
Briquet, Alexandra ULg; Dubois, Sophie ULg; Bekaert, Sandrine ULg et al

in Haematologica (2010), 95(1), 47-56

Background Bone marrow (BM) mesenchymal stem cells (MSC) support proliferation and differentiation of hematopoietic progenitor cells (HPC) in vitro. Since they represent a rare subset of BM cells, MSC ... [more ▼]

Background Bone marrow (BM) mesenchymal stem cells (MSC) support proliferation and differentiation of hematopoietic progenitor cells (HPC) in vitro. Since they represent a rare subset of BM cells, MSC preparations for clinical purposes involves a preparative step of ex vivo multiplication. The aim of our study was to analyze the influence of culture duration on MSC supportive activity. DESIGN AND METHODS: MSC were expanded for up to 10 passages. MSC and CD34(+) cells were seeded in cytokine-free co-cultures after which the phenotype, clonogenic capacity and in vivo repopulating activity of harvested hematopoietic cells were assessed. RESULTS: Early passage MSC supported HPC expansion and differentiation toward both B lymphoid and myeloid lineages. Late passage MSC did not support HPC and myeloid cell outgrowth but maintained B cell supportive ability. In vitro maintenance of NOD/SCID mouse repopulating cells cultured for one week in contact with MSC was effective until the fourth MSC passage and declined afterwards. CD34(+) cells achieved higher levels of engraftment in NOD/SCID mice when co-injected with early passage MSC; however MSC expanded beyond 9 passages were ineffective in promoting CD34(+) cell engraftment. Non-contact cultures indicated that MSC supportive activity involved diffusible factors. Among these, interleukin (IL)-6 and IL-8 contributed to the supportive activity of early passage MSC but not of late passage MSC. MSC phenotype as well as fat, bone and cartilage differentiation capacity did not change during MSC culture. Conclusions Extended MSC culture alters their supportive ability toward HPC without concomitant changes in phenotype and differentiation capacity. [less ▲]

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See detailA Short Statement about Prose Poetry
Delville, Michel ULg

in Sentence: A Journal of Prose Poetics (2010), 8

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See detailCarte hydrogéologique de Wallonie, 1/25000. 64/3-4 Libin-Bras.
Bouezmarni, Mohamed ULg; Denne, Pierre; Debbaut, Vincent ULg

Cartographic material (2010)

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See detailUn virus tapi dans l'ombre : les bases moleculaires de la latence du VIH-1 - Partie I : la physiologie de la latence du VIH-1.
Schwartz, Christian; Le Douce, Valentin; Cherrier, Thomas ULg et al

in Medecine Sciences : M/S (2010), 26(2), 159-63

The introduction of the highly active antiretroviral therapy (HAART) in 1996 has greatly extended survival and raised hopes for the eradication of HIV-1. Unfortunately, the optimism declined by revealing ... [more ▼]

The introduction of the highly active antiretroviral therapy (HAART) in 1996 has greatly extended survival and raised hopes for the eradication of HIV-1. Unfortunately, the optimism declined by revealing the existence of latent HIV-1 reservoirs in cells targeted by the virus. The long-lived HIV-1 reservoirs constitute a major obstacle to the eradication of HIV-1. Understanding the molecular mechanisms of virus latency is essential for efficient therapeutic intervention against the virus. [less ▲]

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See detailUn virus tapi dans l'ombre : les bases moleculaires de la latence du VIH-1 - Partie II : la reactivation de la latence du VIH-1 et ses implications therapeutiques.
Cherrier, Thomas ULg; Le Douce, Valentin; Redel, Laetitia et al

in Medecine Sciences : M/S (2010), 26(3), 291-5

The latent HIV-1 reservoirs established early during infection present a major obstacle for virus eradication. Complete eradication of the virus from infected patients may require a purge of the ... [more ▼]

The latent HIV-1 reservoirs established early during infection present a major obstacle for virus eradication. Complete eradication of the virus from infected patients may require a purge of the reservoirs. Since the development of a HIV-1 vaccine is not achieved, and therefore remains a major challenge for the immunologists, future direction towards an effective curative therapy for HIV-1 infection will rely on the development of original therapeutic strategies which take into account latency, chronic replication and accessibility to tissue-sanctuary. [less ▲]

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See detailHIV-1 regulation of latency in the monocyte-macrophage lineage and in CD4+ T lymphocytes.
Redel, Laetitia; Le Douce, Valentin; Cherrier, Thomas ULg et al

in Journal of Leukocyte Biology (2010), 87(4), 575-88

The introduction in 1996 of the HAART raised hopes for the eradication of HIV-1. Unfortunately, the discovery of latent HIV-1 reservoirs in CD4+ T cells and in the monocyte-macrophage lineage proved the ... [more ▼]

The introduction in 1996 of the HAART raised hopes for the eradication of HIV-1. Unfortunately, the discovery of latent HIV-1 reservoirs in CD4+ T cells and in the monocyte-macrophage lineage proved the optimism to be premature. The long-lived HIV-1 reservoirs constitute a major obstacle to the eradication of HIV-1. In this review, we focus on the establishment and maintenance of HIV-1 latency in the two major targets for HIV-1: the CD4+ T cells and the monocyte-macrophage lineage. Understanding the cell-type molecular mechanisms of establishment, maintenance, and reactivation of HIV-1 latency in these reservoirs is crucial for efficient therapeutic intervention. A complete viral eradication, the holy graal for clinicians, might be achieved by strategic interventions targeting latently and productively infected cells. We suggest that new approaches, such as the combination of different kinds of proviral activators, may help to reduce dramatically the size of latent HIV-1 reservoirs in patients on HAART. [less ▲]

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See detailCombining Mixed Integer Programming and Supervised Learning for Fast Re-planning
Rachelson, Emmanuel ULg; Ben Abbes, Ala; Diemer, Sébastien

in Proceedings of the 22nd IEEE International Conference on Tools with Artificial Intelligence (2010)

We introduce a new plan repair method for problems cast as Mixed Integer Programs. In order to tackle the inherent complexity of these NP-hard problems, our approach relies on the use of Supervised ... [more ▼]

We introduce a new plan repair method for problems cast as Mixed Integer Programs. In order to tackle the inherent complexity of these NP-hard problems, our approach relies on the use of Supervised Learning method for the offline construction of a predictor which takes the problem’s parameters as input and infers values for the discrete optimization variables. This way, the online resolution time of the plan repair problem can be greatly decreased by avoiding a large part of the combinatorial search among discrete variables. This contribution was motivated by the large-scale problem of intra-daily recourse strategy computation in electrical power systems. We report and discuss results on this benchmark, illustrating the different aspects and mechanisms of this new approach which provided close-to-optimal solutions in only a fraction of the computational time necessary for existing solvers. [less ▲]

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