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See detailImpact of growth hormone (GH) deficiency and GH replacement upon thymus function in adult patients.
Morrhaye, Gabriel ULg; Kermani, Hamid; Legros, Jean-Jacques ULg et al

in PLoS ONE (2009), 4(5), 5668

BACKGROUND: Despite age-related adipose involution, T cell generation in the thymus (thymopoiesis) is maintained beyond puberty in adults. In rodents, growth hormone (GH), insulin-like growth factor-1 ... [more ▼]

BACKGROUND: Despite age-related adipose involution, T cell generation in the thymus (thymopoiesis) is maintained beyond puberty in adults. In rodents, growth hormone (GH), insulin-like growth factor-1 (IGF-1), and GH secretagogues reverse age-related changes in thymus cytoarchitecture and increase thymopoiesis. GH administration also enhances thymic mass and function in HIV-infected patients. Until now, thymic function has not been investigated in adult GH deficiency (AGHD). The objective of this clinical study was to evaluate thymic function in AGHD, as well as the repercussion upon thymopoiesis of GH treatment for restoration of GH/IGF-1 physiological levels. METHODOLOGY/PRINCIPAL FINDINGS: Twenty-two patients with documented AGHD were enrolled in this study. The following parameters were measured: plasma IGF-1 concentrations, signal-joint T-cell receptor excision circle (sjTREC) frequency, and sj/beta TREC ratio. Analyses were performed at three time points: firstly on GH treatment at maintenance dose, secondly one month after GH withdrawal, and thirdly one month after GH resumption. After 1-month interruption of GH treatment, both plasma IGF-1 concentrations and sjTREC frequency were decreased (p<0.001). Decreases in IGF-1 and sjTREC levels were correlated (r = 0.61, p<0.01). There was also a decrease in intrathymic T cell proliferation as indicated by the reduced sj/beta TREC ratio (p<0.01). One month after reintroduction of GH treatment, IGF-1 concentration and sjTREC frequency regained a level equivalent to the one before GH withdrawal. The sj/beta TREC ratio also increased with GH resumption, but did not return to the level measured before GH withdrawal. CONCLUSIONS: In patients with AGHD under GH treatment, GH withdrawal decreases thymic T cell output, as well as intrathymic T cell proliferation. These parameters of thymus function are completely or partially restored one month after GH resumption. These data indicate that the functional integrity of the somatotrope GH/IGF-1 axis is important for the maintenance of a normal thymus function in human adults. TRIAL REGISTRATION: ClinicalTrials.gov NTC00601419. [less ▲]

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See detailNovel large ring 1,3 bridged 2-azetidinones as potential inhibitors of penicillin-binding proteins
Urbach, Allan; Dive, Georges ULg; Marchand-Brynaert, Jacqueline

in European Journal of Organic Chemistry (2009), 11

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See detailLarge ring 1,3-bridged 2-azetidinones: experimental and theoretical studies
Urbach, Allan; Dive, Georges ULg; Tinant, Bernard et al

in European Journal of Medicinal Chemistry (2009), 44

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See detailStructural basis of the inhibition of class A beta-lactamases and penicillin-binding proteins by 6-beta-iodopenicillanate
Sauvage, Eric ULg; Zervosen, Astrid ULg; Dive, Georges ULg et al

in Journal of the American Chemical Society (2009), 131(42), 15262-15269

6-Beta-halogenopenicillanates are powerful, irreversible inhibitors of various beta-lactamases and penicillin-binding proteins. Upon acylation of these enzymes, the inhibitors are thought to undergo a ... [more ▼]

6-Beta-halogenopenicillanates are powerful, irreversible inhibitors of various beta-lactamases and penicillin-binding proteins. Upon acylation of these enzymes, the inhibitors are thought to undergo a structural rearrangement associated with the departure of the iodide and formation of a dihydrothiazine ring, but, to date, no structural evidence has proven this. 6-Beta-iodopenicillanic acid (BIP) is shown here to be an active antibiotic against various bacterial strains and an effective inhibitor of the class A beta-lactamase of Bacillus subtilis BS3 (BS3) and the D,D-peptidase of Actinomadura R39 (R39). Crystals of BS3 and of R39 were soaked with a solution of BIP and their structures solved at 1.65 and 2.2 A, respectively. The beta-lactam and the thiazolidine rings of BIP are indeed found to be fused into a dihydrothiazine ring that can adopt two stable conformations at these active sites. The rearranged BIP is observed in one conformation in the BS3 active site and in two monomers of the asymmetric unit of R39, and is observed in the other conformation in the other two monomers of the asymmetric unit of R39. The BS3 structure reveals a new mode of carboxylate interaction with a class A beta-lactamase active site that should be of interest in future inhibitor design. [less ▲]

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See detailaVb3 integrin-targeting Arg-Gly-Asp (RGD) peptidomimetics containing oligo ethylene glycol (OEG) spacers
Rerat, Vincent; Dive, Georges ULg; Cordi, Alex et al

in Journal of Medicinal Chemistry (2009), 52

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See detailAllison Levy. Re-Membering Masculinity in Early Modern Florence: Widowed Bodies, Mourning and Portraiture.
L'Estrange, Elizabeth ULg

in Medieval Feminist Forum [= MFF] (2009), 45

Book Review of Allison Levy's Re-Membering Masculinity in Early Modern Florence: Widowed Bodies, Mourning and Portraiture.

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See detailGenetic diversity of the andean tuber crop species ullucus tuberosus as revealed by molecular (ISSR) and morphological markers
Malice, Marie ULg; Villaroel Vogt, Carmen Licht; Pissard, Audrey et al

in Belgian Journal of Botany (2009), 142(1), 68-82

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See detailOrigine et évolution du cannibalisme dans les populations animales : pourquoi manger son semblable ?
Alabi, Taofic; Patiny, Sébastien; Verheggen, François ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2009), 13

Le cannibalisme est issu d’une déformation linguistique de la terminologie Arawak (Amérindiens des Antilles) caribal qui signifie courageux. Christophe Colomb l’emploie pour désigner les Indiens des ... [more ▼]

Le cannibalisme est issu d’une déformation linguistique de la terminologie Arawak (Amérindiens des Antilles) caribal qui signifie courageux. Christophe Colomb l’emploie pour désigner les Indiens des Caraïbes réputés pour être des mangeurs d’hommes. Le cannibalisme est largement répandu au sein du règne animal. Sa pratique au sein de l’espèce humaine remonte au Paléolithique et persiste encore dans certaines sociétés actuelles, bien qu’elle ne répond pas exclusivement à des besoins alimentaires comme chez les autres espèces animales. Au regard de sa large distribution, il y a lieu de s’interroger sur les causes, origines et avantages évolutifs de ce comportement au sein du règne animal. Le cannibalisme est induit soit par des facteurs écologiques directement liés à une insuffisance des ressources alimentaires, à de fortes densités d’individus et à une hétérogénéité structurale de la population, soit par des facteurs sociaux comme des besoins de reproduction, ou des contraintes de soins parentaux face à une progéniture trop nombreuse. Les avantages de ce comportement sont les gains nutritionnel et énergétique, les gains de territoire pour vivre et se développer. Par contre, les inconvénients résident dans la réduction des effectifs et de la variabilité génétique de la population, ainsi que dans la possibilité de transmission de parasites, virus et de maladies. [less ▲]

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See detailLa vignette de l'etudiant. Conseils pratiques pour le redaction d'un cas clinique.
Scheen, André ULg; Moonen, Gustave ULg

in Revue Médicale de Liège (2009), 64(7-8), 418-22

Case reports are the most accessible publications to the medical student or the practitioner. The appropriate selection of the clinical case that deserves publication is an important first step in the ... [more ▼]

Case reports are the most accessible publications to the medical student or the practitioner. The appropriate selection of the clinical case that deserves publication is an important first step in the process. Afterwards, the report of the case requests much attention, as far as both content and presentation are concerned. The key-message emerging from the clinical case should be emphasized and supported by a clear-cut argumentation. Such an exercise, which might appear difficult at first glance, represents a valuable training for further more complex scientific publications. Here we give some practical advices to help the student or the practitioner who would like to present or publish a case report. [less ▲]

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See detailAmelioration du controle glycemique et perte de poids sous exenatide chez des patients diabetiques de type 2: resultats d'une etude retrospective observationnelle multicentrique belge.
De Block, C.; Paquot, Nicolas ULg; Daoudi, N. et al

in Revue Médicale de Liège (2009), 64(10), 488-95

This is a retrospective analysis of medical records in 4 Belgian diabetes centres of 3 cohorts of patients with type 2 diabetes, with data available, respectively, after 3 months < or =163 patients ... [more ▼]

This is a retrospective analysis of medical records in 4 Belgian diabetes centres of 3 cohorts of patients with type 2 diabetes, with data available, respectively, after 3 months < or =163 patients exposed), 6 months (n=77) and 9 months (n=28) with exenatide therapy. This analysis mainly focuses on the 3 and 6 month cohorts. The mean HbA1 level at baseline averaged 9% and decreased by -1.3% and -1.4% at 3 and 6 months, respectively (-1.5% at 9 months). Neither the duration of diabetes nor initial body weight did influence the metabolic response. The decrease in HbA(1c) at 6 months was greater in patients with higher baseline HbA(1c):-0.5%, -1.4% and -2.4% for a baseline HbA(1c) level <8%, 8-10% and >10%, respectively. At 6 months, the composite criterion of a reduction of HbA(1c) by >1% or a final level <7% was reached by 69% of the cohort. Body weight decreased continuously over time, with a mean reduction of -2.1 kg at 3 months and -3.0 kg at 6 months (-4.9 kg at 9 months). The greater the baseline body weight, the greater the weight loss at final evaluation. Minor nausea and more rarely vomiting were observed, essentially during the first months of exenatide treatment. According to this observational study in routine practice, exenatide may be a valuable alternative to insulin for intensification of treatment of patients with type 2 diabetes after failure of oral drug combination, independently of baseline HbA(1c), body weight and duration of diabetes. [less ▲]

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See detailHarun Farocki: Schnittstelle/Section
Hamers, Jérémy ULg

in Dits : Petites Pièces Traitant d'un Sujet Familier ou d'Actualité (2009), 12(printemps-été 2009), 90-99

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See detailLos trópicos de Mario Vargas Llosa. ¿Tristes tópicos?
Vanden Berghe, Kristine ULg

in Vanden Berghe, Kristine (Ed.) Amazonía. Civilisations et barbaries (2009)

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See detailA Generalization of Semenov's Theorem to Automata over Real Numbers
Boigelot, Bernard ULg; Brusten, Julien ULg; Leroux, Jérôme

in Lecture Notes in Artificial Intelligence (2009), 5663

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See detailA generalization of Cobham's theorem to automata over real numbers
Boigelot, Bernard ULg; Brusten, Julien ULg

in Theoretical Computer Science (2009), 410(18), 1694-1703

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See detailLe démon du journalisme
Durand, Pascal ULg; Mombert, Sarah

in Durand, Pascal; Mombert, Sarah (Eds.) Entre presse et littérature. Le Mousquetaire, journal de M. Alexandre Dumas (1853-1857) (2009)

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See detailThe secretions of oviduct epithelial cells increase the equine in vitro fertilization rate: are osteopontin, atrial natriuretic peptide A and oviductin involved?
Mugnier, S.; Kervella, M.; Douet, C. et al

in Reproductive biology and endocrinology (2009), 7(1), 129

ABSTRACT: BACKGROUND: Oviduct epithelial cells (OEC) co-culture promotes in vitro fertilization (IVF) in human, bovine and porcine species, but no data are available from equine species. Yet, despite ... [more ▼]

ABSTRACT: BACKGROUND: Oviduct epithelial cells (OEC) co-culture promotes in vitro fertilization (IVF) in human, bovine and porcine species, but no data are available from equine species. Yet, despite numerous attempts, equine IVF rates remain low. Our first aim was to verify a beneficial effect of the OEC on equine IVF. In mammals, oviductal proteins have been shown to interact with gametes and play a role in fertilization. Thus, our second aim was to identify the proteins involved in fertilization in the horse. Methods & results In the first experiment, we co-incubated fresh equine spermatozoa treated with calcium ionophore and in vitro matured equine oocytes with or without porcine OEC. We showed that the presence of OEC increases the IVF rates. In the subsequent experiments, we co-incubated equine gametes with OEC and we showed that the IVF rates were not significantly different between 1) gametes co-incubated with equine vs porcine OEC, 2) intact cumulus-oocyte complexes vs denuded oocytes, 3) OEC previously stimulated with human Chorionic Gonadotropin, Luteinizing Hormone and/or oestradiol vs non stimulated OEC, 4) in vivo vs in vitro matured oocytes. In order to identify the proteins responsible for the positive effect of OEC, we first searched for the presence of the genes encoding oviductin, osteopontin and atrial natriuretic peptide A (ANP A) in the equine genome. We showed that the genes coding for osteopontin and ANP A are present. But the one for oviductin either has become a pseudogene during evolution of horse genome or has been not well annotated in horse genome sequence. We then showed that osteopontin and ANP A proteins are present in the equine oviduct using a surface plasmon resonance biosensor, and we analyzed their expression during oestrus cycle by Western blot. Finally, we co-incubated equine gametes with or without purified osteopontin or synthesized ANP A. No significant effect of osteopontin or ANP A was observed, though osteopontin slightly increased the IVF rates. CONCLUSION: Our study shows a beneficial effect of homologous and heterologous oviduct cells on equine IVF rates, though the rates remain low. Furthers studies are necessary to identify the proteins involved. We showed that the surface plasmon resonance technique is efficient and powerful to analyze molecular interactions during fertilization. [less ▲]

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See detailRecherches menées à l'Université de Liège dans le domaine du béton en 2008-2009
Dotreppe, Jean-Claude ULg; Franssen, Jean-Marc ULg; Somja, Hugues et al

Conference given outside the academic context (2009)

Composite steel-concrete columns made of CFSHS filled with self compacting concrete under ambaint temperature and in the fire situation. Design equation for the buckling of high strength concrete columns ... [more ▼]

Composite steel-concrete columns made of CFSHS filled with self compacting concrete under ambaint temperature and in the fire situation. Design equation for the buckling of high strength concrete columns subkected to compression and bending. Improvement of the textural quality of concrete with hydraulic binders. Influence of the reutilisation of OSB panels shuttering on the colour and texture of concrete surfaces. Non destructive methods for the detection of delamination in the decks of concrete bridges [less ▲]

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See detailFurther data on the lichen genus Bacidia s. l. in the Canary Islands and Western Europe, with descriptions of two new species
Brand, Maarten; Coppins, Brian J.; van den Boom, Pieter P. G. et al

in Bibliotheca Lichenologica (2009), 99

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