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See detailL'architecture du paysage: dimension globale traversant les disciplines de l'espace
Occhiuto, Rita ULg

in Cahiers thématiques - architecture conception/territoire/histoire (2006), n.6

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See detailL'école comme lieu privilégié de socialisation
Robert, Jocelyne ULg

in Education-Formation (2006)

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See detailNiets doet zo goed als slechte tijden
Meesters, Gert ULg

Article for general public (2006)

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See detailRita Lejeune fête ses cent ans.
Henrard, Nadine ULg

Article for general public (2006)

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See detailA long-term, open-label trial of the safety and efficacy of etanercept (Enbrel) in patients with rheumatoid arthritis not treated with other disease-modifying antirheumatic drugs
Klareskog, L.; Gaubitz, M.; Rodriguez-Valverde, V. et al

in Annals of the Rheumatic Diseases (2006), 65(12), 1578-1584

Objective: To evaluate the long-term safety and efficacy of etanercept in patients with rheumatoid arthritis. Methods: 549 patients entered this 5-year, open-label extension study and received etanercept ... [more ▼]

Objective: To evaluate the long-term safety and efficacy of etanercept in patients with rheumatoid arthritis. Methods: 549 patients entered this 5-year, open-label extension study and received etanercept 25 mg twice weekly. All patients showed inadequate responses to disease-modifying antirheumatic drugs before entry into the double-blind studies. Safety assessments were carried out at regular intervals. Primary efficacy end points were the numbers of painful and swollen joints; secondary variables included American College of Rheumatology (ACR) response rate, Disease Activity Score and acute-phase reactants. Efficacy was analysed using the last-observation-carried-forward approach. Results: Of the 549 patients enrolled in the open-label trial, 467 (85%), 414 (75%) and 371 (68%) completed 1, 2 and 3 years, respectively; 363 (66%) remained in the study at the time of this analysis. A total exposure of 1498 patient-years, including the double-blind study, was accrued. In the open-label trial, withdrawals for efficacy-related and safety-related reasons were 11% and 13%, respectively. Frequent adverse events included upper respiratory infections, flu syndrome, rash and injection-site reactions. Rates of serious infections and malignancies remained unchanged over the course of the study; there were no reports of patients with central demyelinating disease or serious blood dyscrasias. After 3 years, ACR20, ACR50 and ACR70 response rates were 78%, 51% and 27%, respectively. The Disease Activity Score score was reduced to 3.0 at 3 months and 2.6 at 3 years from 5.1. A sustained improvement was found in Health Assessment Questionnaire scores throughout the 3-year time period. Conclusion: After 3 years of treatment, etanercept showed sustained efficacy and a favourable safety profile. [less ▲]

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See detailAbrege des debuts de la chirurgie cardiaque. Conference prononcee le 6 mai 2006, a l'occasion du 30 eme anniversaire de la chirurgie cardiaque a Liege
Limet, Raymond ULg

in Revue Médicale de Liège (2006), 61(12), 812-9

Beginnings of cardiac surgery were primarily pericardiac surgery: persisting ductus ligation (Gross), coarctation repair (Crafoord) and Blalock's seminal operation of arterio-pulmonary shunt. The first ... [more ▼]

Beginnings of cardiac surgery were primarily pericardiac surgery: persisting ductus ligation (Gross), coarctation repair (Crafoord) and Blalock's seminal operation of arterio-pulmonary shunt. The first really open cardiac procedure is due to Gibbon who worked up an apparatus capable to assume heart and lungs function. In the same time, Lillehei operated on congenital cardiac lesions in children with the concept of "cross-circulation". For a long time confined in Minneapolis and Rochester, cardiac surgery spread all over USA. Starr lead the valvular surgery with the use of caged ball prosthesis (Starr-Edwards); Effler and Favaloro developed coronary surgery; outside USA, the Russian Kolessov used for the first time an internal mammary artery. As far as cardiac transplantation is concerned, a debt is due to Hardy, but the merit of the-first successful cardiac transplantation goes to South-African Barnard. [less ▲]

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See detailChronic low back pain. Good clinical practice (GCP)
Nielens, H.; Van Zundert, J.; Mairiaux, Philippe ULg et al

Report (2006)

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See detailThe in vitro influences of neurotensin on the motility characteristics of human U373 glioblastoma cells
Servotte, S.; Camby, I.; Debeir, O. et al

in Neuropathology & Applied Neurobiology (2006), 32(6), 575-584

Astrocytic tumours are associated with dismal prognoses due to their pronounced ability to diffusely invade the brain parenchyma. Various neuropeptides, including gastrin, are able to modulate tumour ... [more ▼]

Astrocytic tumours are associated with dismal prognoses due to their pronounced ability to diffusely invade the brain parenchyma. Various neuropeptides, including gastrin, are able to modulate tumour astrocyte migration. While neurotensin has been shown to influence the proliferation of glioma cells and the migratory ability of a large set of other cell types, its role in glioma cell migration has never been investigated. Neurotensin-induced modifications to the motility features of human U373 glioblastoma cells therefore constitute the topic of the present study. We evidenced that three subtypes of neurotensin receptors (NTR1, NTR2 and NTR3) are expressed in U373 glioblastoma cells, at least as far as their mRNAs are concerned. Treating U373 tumour cells with 10 nM neurotensin markedly modified the morphological patterns of these cells and also profoundly altered the organization of their actin cytoskeletons. Pull-down assays revealed that neurotensin induced the activation in U373 cells of both Rac1 and Cdc42 but not RhoA. Scratch wound assays evidenced that neurotensin (0.1 and 10 nM) very significantly inhibited wound colonization by U373 cells cultured in the absence of serum. In addition, quantitative phase-contrast videomicroscopy analyses showed that neurotensin decreases the motility levels of U373 glioblastoma cells when these cells are cultured on plastic. In sharp contrast, neurotensin stimulates the motility of U373 cells when they are cultured on laminin, which is a pro-adhesive extracellular matrix component ubiquitously secreted by glioma cells. Our data thus strongly suggest that, in addition to gastrin, neurotensin is a neuropeptide capable of modulating tumour astrocyte migration into the brain parenchyma. [less ▲]

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See detailSurgical treatment of thoraco-abdominal and low thoracic aneurysms of the aorta. One single center experience over ten years
El Arid, J.-M.; CREEMERS, Etienne ULg; Limet, Raymond ULg

in Acta Chirurgica Belgica (2006), 106(6), 669-674

This work presents the results of surgery in thoraco-abdominal aortic aneurysms (TAA) and thoracic descending aortic aneurysms (TDA) in one single center between January 1rst, 1996 and December 31, 2005 ... [more ▼]

This work presents the results of surgery in thoraco-abdominal aortic aneurysms (TAA) and thoracic descending aortic aneurysms (TDA) in one single center between January 1rst, 1996 and December 31, 2005. It concerns open surgery in 42 and endovascular procedures in ten patients. Forty two patients (11 TDA and 31 TAA (4 type I, 12 type II, 6 type III and 9 type IV)) define the open surgery series. Twenty six patients were operated on elective basis and 16 patients in emergency condition. Surgical correction was made under partial cardio-pulmonary bypass (PCPB) in 70% of cases via femoral vessels; most significant intercostal arteries were reimplanted and cerebro-spinal fluid (CSF) drainage used in half of the cases. Operative mortality was zero in the elective group (0/26) and attained 19% in the emergent group (3/16). Mortality was linked to cerebrovascular accidents (CVA) in two cases and post-pump left lung hemorrhagic intarction in one case. The paraplegia accounts 2/26 in the elective group and one in the emergent group (1/16). That is 7.1% in both groups. At the end of five years, survival is 66% in elective group and 74% in the emergency group. Ten patients (5 TDA and 5 TAA (2 type I, 3 type III)) were treated endovascularly. Operative mortality and postoperative paraplegia were nil. [less ▲]

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See detailRetouched Bloom Filters: Allowing Networked Applications to Flexibly Trade Off False Positives Against False Negatives
Donnet, Benoît ULg; Baynat, Bruno; Friedman, Timur

in ACM CoNEXT (2006, December)

Where distributed agents must share voluminous set mem- bership information, Bloom filters provide a compact, though lossy, way for them to do so. Numerous recent networking papers have examined the trade ... [more ▼]

Where distributed agents must share voluminous set mem- bership information, Bloom filters provide a compact, though lossy, way for them to do so. Numerous recent networking papers have examined the trade-offs between the bandwidth consumed by the transmission of Bloom filters, and the er- ror rate, which takes the form of false positives, and which rises the more the filters are compressed. In this paper, we introduce the retouched Bloom filter (RBF), an extension that makes the Bloom filter more flexible by permitting the removal of selected false positives at the expense of gen- erating random false negatives. We analytically show that RBFs created through a random process maintain an overall error rate, expressed as a combination of the false positive rate and the false negative rate, that is equal to the false positive rate of the corresponding Bloom filters. We further provide some simple heuristics that decrease the false posi- tive rate more than than the corresponding increase in the false negative rate, when creating RBFs. Finally, we demon- strate the advantages of an RBF over a Bloom filter in a dis- tributed network topology measurement application, where information about large stop sets must be shared among route tracing monitors. [less ▲]

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See detailDeployment of an Algorithm for Large-Scale Topology Discovery
Donnet, Benoît ULg; Raoult, Philippe; Friedman, Timur et al

in IEEE Journal on Selected Areas In Communications (2006), 24(12), 2210--2220

Topology discovery systems are starting to be in- troduced in the form of easily and widely deployed software. Unfortunately, the research community has not examined the problem of how to perform such ... [more ▼]

Topology discovery systems are starting to be in- troduced in the form of easily and widely deployed software. Unfortunately, the research community has not examined the problem of how to perform such measurements efficiently and in a network-friendly manner. This paper describes several contributions towards that end. These were first presented in the proceedings of ACM SIGMETRICS 2005. We show that standard topology discovery methods (e.g., skitter) are quite inefficient, repeatedly probing the same interfaces. This is a concern, because when scaled up, such methods will generate so much traffic that they will begin to resemble DDoS attacks. We propose two metrics focusing on redundancy in probing and show that both are important. We also propose and evaluate Doubletree, an algorithm that strongly reduces redundancy while maintaining nearly the same level of node and link coverage. The key ideas are to exploit the tree-like structure of routes to and from a single point in order to guide when to stop probing, and to probe each path by starting near its midpoint. Following the SIGMETRICS work, we implemented Doubletree, and deployed it in a real network environment. This paper describes that implementation, as well as preliminary favorable results. [less ▲]

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See detailPromotion de la santé à l'école ... Les modifications tant attendues de deux décrets
Vandoorne, Chantal ULg

in Education Santé (2006), (218), 7-8

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See detailMapping of the bovine growth hormone secretagogue receptor (GHS-R) and polymorphism study in cattle
Colinet, Frédéric ULg; Eggen, André; Gengler, Nicolas ULg et al

Poster (2006, December)

A third control pathway of the Growth Hormone (GH) secretion has come into picture since the development of synthetic compounds known as Growth Hormone Secretagogues (GHSs). The GHS Receptor (GHS-R) and ... [more ▼]

A third control pathway of the Growth Hormone (GH) secretion has come into picture since the development of synthetic compounds known as Growth Hormone Secretagogues (GHSs). The GHS Receptor (GHS-R) and its subtype are abundantly located in the hypothalamus-pituitary unit, but are also distributed in other central areas and peripheral tissues. The GHS-R belongs to the G-protein coupled receptor family with seven transmembrane domain architecture. In order to determine the GHS-R gene sequence, total mRNA was extracted from abomasum and two types of GHS-R cDNA were identified. These two types are transcript variants (1a and 1b) of the same GHS-R gene. The gene encompasses two exons and a single intron. Using a 3000 Rad hybrid panel, the GHS-R gene was mapped to Bos taurus autosome 1 (BTA 1). This localization on BTA 1 agrees totally with comparative data between cattle and human since BTA 1 corresponds to part of human chromosome 3 where human GHSR is also mapped. By two-point analysis, most significantly linked marker are BL26 and BMS4031 (both LOD score : 5,66). Some studies detected different QTLs near these markers like for growth rate, carcass yield, milk portein and milk yield. In the cattle industry, it is of economical importance to increase plasma GH secretion because it is associated with faster growth, less fat stores and improved milk production. Being of economical importance and the detected QTLs near the GHS-R gene, it would be interesting to study the polymorphism on the bovine GHS-R gene. Screening for polymorphisms in the two exons on ten Belgian Blue bulls, ten Holsteins bulls and ten Limousin bulls revealed a total of four single nucleotide polymorphisms (SNPs): three SNPs are in the first exon and one SNP in the second exon. In order to evaluate if GHS-R could be involved in genetic variation for growth rate, carcass yield, milk portein and milk yield, an association study between SNPs on GHS-R gene and these traits could be performed in a major cattle population. [less ▲]

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See detailApplication of MRI for improved local control in complex radiotherapy of cervical cancer
Janaki, Hadjiev; Zsolt, Cselik; Péter Bogner et al

in Archive of Oncology (2006), 14(3-4), 95-100

Background: The aim of this study was to analyze the use of magnetic resonance imaging (MRI) as a modern medical imaging technique in radiotherapy with special emphasis on the integration of MRI and a ... [more ▼]

Background: The aim of this study was to analyze the use of magnetic resonance imaging (MRI) as a modern medical imaging technique in radiotherapy with special emphasis on the integration of MRI and a novel technique in brachytherapy to optimize treatment outcome in cervical cancer. Methods: In addition to the CT based shrinking volume conformal teletherapy in 31 patients with locally advanced cervical cancer, MRI examination with a special adjustable applicator at the treatment site was performed for the brachytherapy planning. To avoid excessive doses to the healthy structures during complex cervical radiotherapy isodose curves were calculated upon the information of the MR image and dose distribution was evaluated. Results: The consecutive application of CT and MRI limited the possibility for overdosage of the critical organs and undertreatment of the advanced tumor spread in all cases. The overall response rate for the complex treatment was 74.2% with complete regression in 25.8% of the cases. Based on the exact information of the three dimensional digital data radiation doses could be optimized without increasing the possibility of acute complications rate. Conclusion: The introduction of 3D treatment planning for teletherapy pelvic and boost irradiation of cervical carcinoma as well as for the brachytherapy part of the complex treatment is to be recommended. [less ▲]

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See detailAssessment of trophic relationships between symbiotic tropical ophiuroids using C and N stable isotope analysis
Fourgon, Didier; Lepoint, Gilles ULg; Eeckhaut, Igor

in Journal of the Marine Biological Association of the United Kingdom (2006), 86(6), 1443-1447

Analyses of the natural abundance of carbon and nitrogen stable isotopes were performed to investigate the feeding habits of two ophiurolds, Ophiomastix venosa and Ophiocoma scolopendrina, and to assess ... [more ▼]

Analyses of the natural abundance of carbon and nitrogen stable isotopes were performed to investigate the feeding habits of two ophiurolds, Ophiomastix venosa and Ophiocoma scolopendrina, and to assess the potential benefit obtained by the symbiotic Ophiomastix venosa juveniles. A tracer experiment was also carried Out to clarify the contribution of algae to the nitrogen uptake amongst the tested ophiurolds. Our results suggest that Ophiocoma scolopendrina adults occupy a higher position in the food web than Ophiomastix venosa and mainly feed on neuston. In contrast, O. venosa adults feed on the alga Sargassum densifolium, and on organic matter associated with sediment. Free juveniles and symbiotic juveniles of O. venosa have intermediate PC values between both adult species. The high proportion of C-13 in the symbiotic juveniles compared to the one in their conspecific adults indicates that their diet slightly differs from the latter and is closer to that of Ophiocoma scolopendrina. This raises the hypothesis that symbiotic juveniles steal neuston front their associated host, O. scolopendrina. [less ▲]

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See detailAutobiographical memory in non-amnesic alcohol-dependent patients
D'Argembeau, Arnaud ULg; Van der Linden, Martial ULg; Verbanck, Paul et al

in Psychological Medicine (2006), 36(12), 1707-1715

Background. Chronic alcohol abuse is associated with a wide range of cognitive deficits. However, little is known about memory for real-life events (autobiographical memory) in non-amnesic alcoholic ... [more ▼]

Background. Chronic alcohol abuse is associated with a wide range of cognitive deficits. However, little is known about memory for real-life events (autobiographical memory) in non-amnesic alcoholic patients. The purpose of this study was to investigate (a) non-amnesic alcoholics' ability to recall specific autobiographical memories and (b) their subjective experience when they access specific memories.Method. Twenty non-amnesic (without Korsakoff syndrome) recently detoxified alcoholics and 20 healthy controls completed the Autobiographical Memory Test (AMT), which assesses the frequency of specific (versus general) memories recalled in response to cue words, and the Memory Characteristics Questionnaire (MCQ), which assesses subjective experience (e.g. the amount of sensory and contextual details experienced) when remembering specific events.Results. Alcoholic patients recalled specific memories less frequently and general memories more frequently than healthy controls. Nevertheless, when a specific past event was accessed, alcoholic patients subjectively experienced as many sensory and contextual details as controls.Conclusions. These findings suggest that non-amnesic alcoholics have difficulties strategically accessing event-specific autobiographical knowledge, which might result from changes in frontal lobe function that are associated with alcoholism. [less ▲]

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See detailComment je traite ... une grossesse extra-uterine
Degee, S.; Dricot, J. F.; Lamborelle, S. et al

in Revue Médicale de Liège (2006), 61(12), 797-803

Nowadays, the management of ectopic pregnancy should be codified as often as possible. Two types of treatment are possible. One surgical and the other medical. Our study is concerned with a series of 97 ... [more ▼]

Nowadays, the management of ectopic pregnancy should be codified as often as possible. Two types of treatment are possible. One surgical and the other medical. Our study is concerned with a series of 97 patients hospitalized for suspicion of ectopic pregnancy for whom the risk factors and treatment were analyzed. Our conclusion is that the medical treatment should be more frequently proposed and surgery should prefer the conservative treatment whenever it is still possible. [less ▲]

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See detailImpact of 2D and 3D vision on performance of novice subjects using da Vinci robotic system
Blavier, Adelaïde ULg; Gaudissart, Quentin; Cadière, Guy-Bernard et al

in Acta Chirurgica Belgica (2006), 106(6), 662-664

Purpose of the study : The aim of this study was to evaluate the impact of 3D and 2D vision on performance of novice subjects using da Vinci robotic system. Methods : 224 nurses without any surgical ... [more ▼]

Purpose of the study : The aim of this study was to evaluate the impact of 3D and 2D vision on performance of novice subjects using da Vinci robotic system. Methods : 224 nurses without any surgical experience were divided into two groups and executed a motor task with the robotic system in 2D for one group and with the robotic system in 3D for the other group. Time to perform the task was recorded. Results : Our data showed significant better time performance in 3D view (24.67 +/- 11.2) than in 2D view (40.26 +/- 17.49, P < 0.001). Conclusions : Our findings emphasized the advantage of 3D vision over 2D view in performing surgical task, encouraging the development of efficient and less expensive 3D systems in order to improve the accuracy of surgical gesture, the resident training and the operating time. [less ▲]

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See detailLe genotypage RHD foetal sur sang maternel dans le suivi prenatal des patientes Rh D negatif
Dricot, J. F.; Minon, J. M.; Schaaps, Jean-Pierre ULg et al

in Revue Médicale de Liège (2006), 61(12), 820-6

Since the beginning of RHD genotyping in maternal plasma, no Rh D positive baby was diagnosed RHD negative in our institution. Genotyping from circulating DNA in maternal plasma is as efficient as ... [more ▼]

Since the beginning of RHD genotyping in maternal plasma, no Rh D positive baby was diagnosed RHD negative in our institution. Genotyping from circulating DNA in maternal plasma is as efficient as genotyping on amniocyts but without the associated risks. We propose a prophylactic injection based on fetal genotyping RHD in maternal blood with 300 microg anti-D immunoglobulin at 28 weeks of amenhorrea in all of Rh D negative pregnant women whitch fetuses positive RHD. [less ▲]

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