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See detailPrévention de l'insuffisance rénale chronique chez l'adulte
Krzesinski, Jean-Marie ULg; Dubois, Bernard ULg; Rorive, Georges ULg

in Revue Médicale de Liège (2003), 58(6), 369-377

Chronic renal failure is an unrecognised disease, with an insidious and rather silent development, for which the general practitioners are too often passive. This review would like to insist on the ... [more ▼]

Chronic renal failure is an unrecognised disease, with an insidious and rather silent development, for which the general practitioners are too often passive. This review would like to insist on the detection of people at risk or with early abnormalities, on the optimal guidelines to slowdown the evolution to more severe and irreversible stages, on the prevention of uremic and cardiovascular complications and on the preparation to end stage renal treatments. [less ▲]

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See detailThe new digitized geological map of Wallonia and its applications
Barchy, Laurent; Marion, Jean-Marc ULg

Poster (2003, June)

Objectives: understanding of geological phenomena, development of new methodologies and techniques, to produce and disseminate pertinent, high-quality data and to provide for public authorities: - Surface ... [more ▼]

Objectives: understanding of geological phenomena, development of new methodologies and techniques, to produce and disseminate pertinent, high-quality data and to provide for public authorities: - Surface, subsurface and natural-ressource management - Preventing natural risks and pollution - Regional planning and developmentthe necessary tools [less ▲]

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See detailComprehensive Two-Dimensional Gas Chromatography Time-of-Flight Mass
Patterson Jr; Focant, Jean-François ULg

Scientific conference (2003, June)

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See detailNew geological map of Wallonia (south part of Belgium)... Now Online. Integration with other mapping projects of the Walloon Region Ministry
Barchy, Laurent; Marion, Jean-Marc ULg

Poster (2003, June)

Objectives: understanding of geological phenomena, development of new methodologies and techniques, to produce and disseminate pertinent, high-quality data and to provide for public authorities: - Surface ... [more ▼]

Objectives: understanding of geological phenomena, development of new methodologies and techniques, to produce and disseminate pertinent, high-quality data and to provide for public authorities: - Surface, subsurface and natural-ressource management - Preventing natural risks and pollution - Regional planning and developmentthe necessary tools [less ▲]

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See detailExistence d'une prescription d'ordre naturelle projectivement invariante
Radoux, Fabian ULg

Master's dissertation (2003)

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See detailEvaluation of the patient's quality of life by her relative in a breast cancer population
Bragard, Isabelle ULg; Conradt, S.; Barchiesi, D. et al

in Psycho-Oncology (2003, June), 12(4, Suppl. S), 205-206

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See detailCardiologists and smoking
Kesteloot, H.; Pierard, Luc ULg

in Acta Cardiologica (2003), 58(3), 177-177

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See detailPrevention de la mortalite secondaire apres anevrysme dissequant de type B
Quaniers, Janine ULg; CREEMERS, Etienne ULg; Djekic, J. et al

in Revue Médicale de Liège (2003), 58(6), 400-3

Only few dissecting aneurysms type A survive without surgery. Opposingly, the dissecting aneurysms type B are successfully managed by the medical treatment "anti-impulsion". A personal series is reported ... [more ▼]

Only few dissecting aneurysms type A survive without surgery. Opposingly, the dissecting aneurysms type B are successfully managed by the medical treatment "anti-impulsion". A personal series is reported, that evidence important cardiovascular mortality in the follow-up in chronic dissecting aneurysms type B; one part of this late mortality is linked to rupture of the thoracic descending aorta. Thus, the prevention of this late mortality depends on a strict follow-up of the characters and dimensions of descending aortic thoracic aorta. [less ▲]

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See detailTransplantation cardiaque: prevention secondaire
Nellessen, Eric ULg; Lancellotti, Patrizio ULg; Demoulin, J. C. et al

in Revue Médicale de Liège (2003), 58(6), 429-34

Cardiac transplantation is the treatment of choice for refractory heart failure. An immunosuppressive therapy must be given in the perioperative course to avoid graft rejection. In this article, we review ... [more ▼]

Cardiac transplantation is the treatment of choice for refractory heart failure. An immunosuppressive therapy must be given in the perioperative course to avoid graft rejection. In this article, we review the main classes of immunosuppressive agents (calcineurin inhibitors, anti-metabolities, corticoids) and their side effects. The general preventive measures and the different kinds of rejection (hyperacute, acute vascular, acute cellular and chronical) are discussed. The current bacterial, protozoarian, mycotic and viral infections are described. We finish with the risk of cancer, mainly skin tumours and non-Hodgkinian lymphomas. [less ▲]

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See detailAlteration of left ventriculo-arterial coupling and mechanical efficiency during acute myocardial ischemia
Kolh, Philippe ULg; Lambermont, Bernard ULg; Ghuysen, Alexandre ULg et al

in International Angiology (2003), 22(2), 148-158

AIM: Myocardial revascularisation being frequently performed during acute myocardial ischemia, in a hostile hemodynamic environment, we evaluated left ventriculo-arterial (VA) coupling, left ventricular ... [more ▼]

AIM: Myocardial revascularisation being frequently performed during acute myocardial ischemia, in a hostile hemodynamic environment, we evaluated left ventriculo-arterial (VA) coupling, left ventricular (LV) mechanical efficiency, and the mechanical properties of the systemic vasculature during acute myocardial ischemia. METHODS: In 6 pigs, vascular properties [characteristic impedance (R(1)), peripheral resistance (R(2)), compliance (C), inductance (L), arterial elastance (E(a))] were estimated with a windkessel model. LV function was assessed by the slope (E(es)) of end-systolic pressure-volume relationship (ESPVR), and stroke work (SW) - end-diastolic volume (EDV) relation. Pressure-volume area (PVA) was referred to as myocardial oxygen consumption. VA coupling was defined as E(es)/E(a), and mechanical efficiency as SW/PVA. After baseline recordings, the left anterior descending coronary artery was ligated and hemodynamic measures obtained every 30 minutes for 3 hours. Data are expressed as mean (SEM). RESULTS: Coronary occlusion induced an ESPVR rightward shift, and decreased E(es) from 3.67 (0.33) to 1.92 (0.20) mmHg/ml and the slope of the SW - EDV relationship from 72.3 (3.4) to 40.4 (4.5) mmHg (p<0.001), while E(a) increased from 3.33 (0.56) to 4.65 (0.29) mmHg/ml (p<0.005). This was responsible for a dramatic alteration of VA coupling from 1.22 (0.11) to 0.44 (0.07), (p<0.001). While R2 increased from 1.72 (0.30) to 2.38 (0.16) mmHg x s x ml(-1) (p<0.05) and C decreased from 0.78 (0.16) to 0.46 (0.08) ml/mmHg (p<0.05), R(1) and L were unchanged. Coronary occlusion decreased SW from 4056 (223) to 2580 (122) mmHg.ml (p<0.001), while PVA and SW/PVA decreased from 5575 (514) to 4813 (317) mmHg x ml (NS), and from 0.76 (0.04) to 0.57 (0.03) (p<0.001), respectively. CONCLUSION: Acute myocardial ischemia severely altered left ventriculo-arterial coupling and LV mechanical efficiency. Impaired left VA coupling was due to a combination of augmented arterial elastance, secondary to early vasoconstriction later associated with decreased arterial compliance, and decreased LV contractility. [less ▲]

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See detailApplication de l’échographie à l’ovum pick up chez la jument. Effet de la cystéamine sur la maturation des ovocytes équins mesuré par coloration au bis-benzamide et par transfert d’ovocytes.
Deleuze, Stefan ULg

Master's dissertation (2003)

Afin d’analyser l’effet de la cystéamine sur la maturation et la fécondation des ovocytes équins nous avons collecté des ovocytes par ponction folliculaire transvaginale échoguidée. Les ovocytes ont été ... [more ▼]

Afin d’analyser l’effet de la cystéamine sur la maturation et la fécondation des ovocytes équins nous avons collecté des ovocytes par ponction folliculaire transvaginale échoguidée. Les ovocytes ont été cultivés in vitro pendant 30 heures, puis transférés dans l’oviducte de juments receveuses inséminées. Nous avons utilisé le stade nucléaire après maturation in vitro comme critère de maturation nucléaire et les taux de production d’embryons après transfert d’ovocytes comme critère de maturation cytoplasmique. Contrairement à ce qui a été observé dans d’autres espèces, aucun effet positif de la cystéamine sur la maturation in vitro n’a pu être démontré par notre protocole. D’autres travaux sur les effets de la cystéamine et sur les mécanismes de la maturation in vitro des ovocytes équins sont nécessaires. [less ▲]

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See detailDose-dependent modulation of choroidal neovascularization by plasminogen activator inhibitor type 1: Implications for clinical trials
Lambert, Vincent ULg; Munaut, Carine ULg; Carmeliet, Peter et al

in Investigative Ophthalmology & Visual Science (2003), 44(6), 2791-2797

PURPOSE. To explain the conflicting reports about the influence of plasminogen activator inhibitor type (PAI-1) on pathologic angiogenesis, such as occurs during the exudative form of age-related macular ... [more ▼]

PURPOSE. To explain the conflicting reports about the influence of plasminogen activator inhibitor type (PAI-1) on pathologic angiogenesis, such as occurs during the exudative form of age-related macular degeneration. METHODS. The expression of PAI-1 mRNA was analyzed in human and murine choroidal neovascularization (CNV) by RTPCR. The influences of increasing doses of recombinant PAI-1 were evaluated by daily intraperitoneal injections in PAI-1-1-and wild-type animals with a model of laser-induced CNV. The double mechanism of action of PAI-1 (proteolytic activity inhibition versus vitronectin binding) was explored by immunohistochemical localization of fibrinogen/fibrin and by injection of recombinant PAI-1 protein defective for vitronectin binding or with adenoviral vectors bearing a mutated binding-deficient PAI-1 gene. RESULTS. PAI-1 expression was present in human CNV and strongly induced in the course of experimental subretinal neovascularization. Daily injections of recombinant PAI-1 proteins in control and PAI-1(-/-) animals demonstrated that PAI-1 could exhibit both pro- and antiangiogenic effects, dependent on the dose. PAI-1 mutants defective for vitronectin binding were used to show that PAI-1 promotes choroidal pathologic angiogenesis merely through its antiproteolytic activity. CONCLUSIONS. These observations may help to reconcile reports with opposite results regarding the effects of PAI-1 on angiogenesis and certainly warn against uncontrolled use of PAL I modulating drugs in clinical trials. [less ▲]

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See detailPolyneuritis equi. Literatuurstudie & retrospectieve studie
Van Galen, Gaby ULg

Master's dissertation (2003)

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See detailLa prise en charge cardiaque preoperatoire du patient vasculaire
Van Damme, Hendrik ULg; Larbuisson, Robert ULg; Limet, Raymond ULg

in Revue Médicale de Liège (2003), 58(6), 409-14

Peripheral vascular surgery (carotid, infrainguinal or aortoiliacal) is characterised by an increased cardiac risk with an infarction rate of 1 to 4%. Sixty percent of the vascular patients present a ... [more ▼]

Peripheral vascular surgery (carotid, infrainguinal or aortoiliacal) is characterised by an increased cardiac risk with an infarction rate of 1 to 4%. Sixty percent of the vascular patients present a concomitant coronary artery disease, often infraclinically. Preoperative cardiac risk stratification aims at reducing cardiac related morbidity and mortality. A clinical risk profile (patient's past history) and non-invasive cardiac tests allow subdividing the vascular patients into three categories: high risk, intermediate risk, and low risk. High-risk patients (unstable angina, recent infarction, overt congestive heart failure and critical aortic valve stenosis) require immediate intensive management of their underlying cardiac disease. This means delay or annulation of the planned vascular operation. For intermediate risk patients, a clinical cardiac risk index based on patient's past history (stable angina, previous infarction or episode of congestive heart failure, age of 70 years or more and diabetes) offers a rough orientation. These clinical markers lack specificity, since they are found in almost all vascular patients. The adjunction of a non-invasive cardiac testing allows to optimise the cardiac risk evaluation. Stress echocardiography with dobutamine has become a very popular test, with a negative predicting value exceeding 90%, but with a lack of specificity (many vascular patients have an uneventful postoperative outcome, despite a positive dobutamine test). These inconsistent results of cardiac risk evaluation render their routine use questionable. Nowadays, the management of patients requiring vascular surgery is based on the concept that every vascular patient should be considered as suffering from coronary artery disease. A certain degree of myocardial protection should be offered to every vascular surgery candidate. A preoperative treatment with betablockers provides myocardial protection against the operative stress and lowers myocardial oxygen requirement. There are arguments to continue or start aspirin treatment in the preoperative period, in order to lower the risk of sudden coronary thrombosis. [less ▲]

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See detailPrevention de la necrose des membres inferieurs et de l'amputation par pontages femoro-tibiaux: indications, technique et resultats
Van Damme, Hendrik ULg; Baguet, E.; Zhang, Lihong ULg et al

in Revue Médicale de Liège (2003), 58(6), 415-28

Limb threatening ischemia is a challenge for the vascular surgeon. Recent progress in revascularization procedures allow to minimize the primary amputation rate in the management of chronic critical limb ... [more ▼]

Limb threatening ischemia is a challenge for the vascular surgeon. Recent progress in revascularization procedures allow to minimize the primary amputation rate in the management of chronic critical limb ischemia. The authors discuss the prevalence and causes of chronic critical limb ischemia, with a special interest for diabetic arteriopathy. The technique of crural and pedal vessel revascularization is described, as well as the innovative tourniquet technique for distal bypass surgery. A review of published series of infrapopliteal bypass surgery is made. The experience of the authors during last decade with crural and pedal bypass surgery is analyzed. [less ▲]

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See detailAnisotropic AC behavior of multifilamentary Bi-2223/Ag tapes
Fagnard, Jean-François ULg; Vanderbemden, Philippe ULg; Cloots, Rudi ULg et al

in IEEE Transactions on Applied Superconductivity (2003), 13(2, Part 3), 2976-2979

In this communication, we report on the anisotropy of the superconducting properties of multifilamentary Bi-based tapes experimentally investigated by AC magnetic susceptibility measurements. The ... [more ▼]

In this communication, we report on the anisotropy of the superconducting properties of multifilamentary Bi-based tapes experimentally investigated by AC magnetic susceptibility measurements. The susceptibility X = X' - jX" was measured using a commercial system and a couple of orthogonal pick-up coils. The X'' vs. temperature curves were shown to exhibit two peaks. The smaller of the peaks, occurring near T = 72 K, was only visible for particular field directions and within a given frequency window. Such results point out the role played by the phase difference between the applied magnetic field and the internal magnetic field seen by the filaments. (C) 2003 IEEE. [less ▲]

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See detailSolution of topology optimization problems with sequential convex programming
Duysinx, Pierre ULg; Bruyneel, Michaël ULg; Fleury, Claude ULg

Speech (2003)

Introduction to efficient solution algorithms to large scale topology optimization problems.

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See detailOral monthly ibandronate: rationale and clinical potential in postmenopausal osteoporosis
Reginster, Jean-Yves ULg; McClung, M.; Coutant, K. et al

in Annals of the Rheumatic Diseases (2003, June)

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