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See detailEarly-type stars in the young open cluster IC 1805 - I. The SB2 system BD+60 degrees 497 and the probably single stars BD+60 degrees 501 and BD+60 degrees 513
Rauw, Grégor ULg; De Becker, Michaël ULg

in Astronomy and Astrophysics (2004), 421(2), 693-702

We investigate the multiplicity of three O-type stars in the very young open cluster IC 1805. All our targets were previously considered as spectroscopic binaries, but no orbital solution was available ... [more ▼]

We investigate the multiplicity of three O-type stars in the very young open cluster IC 1805. All our targets were previously considered as spectroscopic binaries, but no orbital solution was available for any of them. Our results confirm the binarity of BD+60degrees 497 and we provide the very first orbital solution for this double-lined spectroscopic binary. This is only the second O-star binary in IC 1805, and the first SB2 system, for which an orbital solution is now available. BD+60degrees 497 has an orbital period of 3.96 days and consists of an evolved 06.5 V((f)) primary and an 08.5-9.5 V((f)) secondary with minimum masses of m, sin(3) i = 13.9 M-circle dot and m(2) sin 3 i = 10.9 M-circle dot. The observed primary/secondary mass ratio (1.28) appears lower than expected from a comparison with single star evolutionary models (1.60-1.74). For the other two stars, BD+60degrees 501 and BD+60degrees 513, we find no significant radial velocity variations, suggesting that they are most probably single. Although a fraction of binaries among the early-type stars of IC 1805 as high as 80% has been advocated in the literature, our results suggest that this number might be overestimated. [less ▲]

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See detailBulletin agrométéorologique - Juin 2004
Tychon, Bernard ULg; Ozer, Pierre ULg; Horion, S. et al

in Bulletin Agrométéorologique (2004), 3(3), 1-5

Les paramètres climatiques du mois de juin furent tous proches de la moyenne, exception faite de l'ensoleillement qui fut largement déficitaire sur l’est du pays. La situation des céréales d’hiver et de ... [more ▼]

Les paramètres climatiques du mois de juin furent tous proches de la moyenne, exception faite de l'ensoleillement qui fut largement déficitaire sur l’est du pays. La situation des céréales d’hiver et de la pomme de terre est globalement favorable laissant entrevoir des rendements généralement supérieurs à ceux de 2003. Par contre, les prévisions relatives au maïs fourrager et à la betterave sucrière montrent que ces cultures pourraient connaître, au niveau national, une légère baisse par rapport à l’année passée. [less ▲]

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See detailNd and Pb isotope signatures of the clay-size fraction of Labrador Sea sediments during the Holocene: Implications for the inception of the modern deep circulation pattern
Fagel, Nathalie ULg; Hillaire-Marcel, Claude ULg; Humblet, Marc et al

in Paleoceanography (2004), 19(3),

Nd and Pb isotopes were measured on the fine fraction of one sediment core drilled off southern Greenland. This work aims to reconstruct the evolution of deep circulation patterns in the North Atlantic ... [more ▼]

Nd and Pb isotopes were measured on the fine fraction of one sediment core drilled off southern Greenland. This work aims to reconstruct the evolution of deep circulation patterns in the North Atlantic during the Holocene on the basis of sediment supply variations. For the last 12 kyr, three sources have contributed to the sediment mixture: the North American Shield, the Pan-African and Variscan crusts, and the Mid-Atlantic Ridge. Clay isotope signatures indicate two mixtures of sediment sources. The first mixture (12.2-6.5 ka) is composed of material derived from the North American shield and from a "young'' crustal source. From 6.5 ka onward the mixture is characterized by a young crustal component and by a volcanic component characteristic of the Mid-Atlantic Ridge. Since the significant decrease in proximal deglacial supplies, the evolution of the relative contributions of the sediment sources suggests major changes in the relative contributions of the deep water masses carried by the Western Boundary Undercurrent over the past 8.4 kyr. The progressive intensification of the Western Boundary Undercurrent was initially associated mainly with the transport of the Northeast Atlantic Deep Water mass until 6.5 ka and with the Denmark Strait Overflow Water thereafter. The establishment of the modern circulation at 3 ka suggests a reduced influence of the Denmark Strait Overflow Water, synchronous with the full appearance of the Labrador Seawater mass. Our isotopic data set emphasizes several changes in the relative contribution of the two major components of North Atlantic Deep Water throughout the Holocene. [less ▲]

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See detailRecent progress in the macromolecular engineering of aliphatic polyesters
Jérôme, Robert ULg; Li, Haiying; Rieger, Jutta et al

Conference (2004, July 04)

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See detailErratum: VLT + UVES spectroscopy of the low-ionization intrinsic absorber in SDSS J001130.56+005550.7
Hutsemekers, Damien ULg; Hall, Patrick; Brinkmann, J.

in Astronomy and Astrophysics (2004), 422

Not Available

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See detailSkin cancer screening campaign in the German speaking Community of Belgium.
Nikkels, Arjen ULg; Tassoudji, Nazli ULg; Jerusalem-Noury, E. et al

in Acta Clinica Belgica (2004), 59(4), 194-8

The incidence of primary malignant melanoma (MM) and skin carcinomas, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), is progressively raising. As long as their diagnosis and ... [more ▼]

The incidence of primary malignant melanoma (MM) and skin carcinomas, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), is progressively raising. As long as their diagnosis and therapeutic managements are initiated early, their prognosis remains favorable. This underlines the importance of early recognition of skin cancers. Furthermore, it has been demonstrated that skin cancer screening programs are efficacious in increasing the population awareness of the early signs of skin cancer and of the dangers of UV - exposure. A skin cancer screening campaign was organised by dermatologists of the German-speaking Community of Belgium in cooperation with the Department of Family, Health, and Social Affairs of the Regional Ministry of the German-speaking Community of Belgium. In order to increase the screening selectivity, two risk populations were targeted; patients presenting 30 or more moles, and patients over 50 years of age presenting recent skin changes of the head and neck area. A media campaign using radio, television and daily press was started to increase the population awareness of the dangers of UV exposure and of the early signs of skin cancer. During 2 screening days, three-hour sessions were organised in 2 health centers located in Eupen and St Vith. A total of 148 patients were examined. A total of 124/148 patients met the selection criteria predefined during the media announcement. The simultaneous presence of 4 dermatologists during the screening sessions allowed a second opinion for warning lesions. Four BBCs as well as 23 patients pesenting dysplastic nevi were clinically diagnosed. During the 2 months following the screening campaign 5 MMs were identified by the same dermatologists in their routine practice. In conclusion, this skin cancer screening campaign led to the diagnosis of 4 carcinomas. The campaign furthermore increased the patient awareness, permitting the diagnosis of 5 MMs during the 2 following months. This figure represents about 30% of all MMs diagnosed yearly in this region of Belgium. [less ▲]

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See detailHormonal and biochemical normalization and tumor shrinkage induced by anti-parathyroid hormone immunotherapy in a patient with metastatic parathyroid carcinoma.
Betea, Daniela ULg; Bradwell, A. R.; Harvey, T. C. et al

in Journal of Clinical Endocrinology and Metabolism (2004), 89(7), 3413-20

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism, and the efficacy of medical therapy and chemo- and radiotherapy is poor in recurrent or metastatic disease. We report the first case ... [more ▼]

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism, and the efficacy of medical therapy and chemo- and radiotherapy is poor in recurrent or metastatic disease. We report the first case of PTH immunization in which tumor shrinkage accompanied hormonal, biochemical, and clinical improvements in a patient with metastatic parathyroid carcinoma.A 50-yr-old woman with refractory parathyroid carcinoma and pulmonary metastases was immunized eight times between February 2001 and December 2003 with bovine and modified human PTH fragments and intact human PTH, mixed with Freund's adjuvant. Total and ionized calcium and PTH levels were assayed weekly for 6 months and regularly thereafter. Thoracic computed tomography scans were performed regularly.Antibodies to all PTH fragments were detected after two immunizations. Baseline PTH and total calcium were 213.0 ng/liter and 13.96 mg/dl, respectively, and remained elevated during the first three immunizations. From the fourth immunization onward, PTH and calcium decreased, and the patient's clinical condition improved markedly. PTH and calcium levels have remained controlled for more than 24 months, and the sizes (surface area) of pulmonary metastases decreased from baseline by 39-71%.This is the first evidence that PTH immunization not only can improve clinical, hormonal, and biochemical measures in parathyroid carcinoma but also has an antitumor effect. [less ▲]

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See detail3D simulation of Industrial Hall in case of fire. Benchmark between ABAQUS, ANSYS and SAFIR
Vassart, Olivier; Cajot, Louis-Guy; O'Connor, Marc et al

in Interflam2004 Proceedings. Fire Sciences and Engineering Conference (2004, July)

For simple storey buildings, the structural behaviour in case of fire is relevant only for the safety of the firemen. The protection of occupants and goods is a matter of fire spread, smoke propagation ... [more ▼]

For simple storey buildings, the structural behaviour in case of fire is relevant only for the safety of the firemen. The protection of occupants and goods is a matter of fire spread, smoke propagation, active fire fighting measures and evacuation facilities. Brittle failure, progressive collapse and partial failure of façades elements outwards may endanger the fire fighters and have to be avoided. In order to deal with such an objective, the simulation softwares has to cover the 3D structural behaviour including membrane and restrained effects as well as the failure mode so that post-local failure stage can be analysed. Such calculation models (ANSYS, ABAQUS and SAFIR [1]) have been compared true a benchmark. In this benchmark, two different users used ABAQUS. [less ▲]

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See detailGeneralized parton distributions of the pion
Bissey, F.; Cudell, Jean-René ULg; Cugnon, Joseph ULg et al

in Nuclear Physics B-Proceedings Supplements (2004, July), 133

Off-forward structure functions of the pion are investigated in twist-two and twist-three approximation. A simple model is used for the pion, which allows to introduce finite size effects, while ... [more ▼]

Off-forward structure functions of the pion are investigated in twist-two and twist-three approximation. A simple model is used for the pion, which allows to introduce finite size effects, while preserving gauge invariance. Results for the imaginary parts of the gamma*pi --> gamma*pi off-forward amplitude and of the structure functions are presented. Generalized Callan-Gross relations are obtained. [less ▲]

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See detailInterest and feasibility of a modified supine position for posterior cranial fossa surgical procedures.
Graftieaux, J-P; Litré, Claude Fabien ULg; Gomis, P et al

in Annales Françaises d'Anesthésie et de Réanimation (2004)

The sitting position is considered as a gold standard for posterior fossa surgical procedures. However, in order to decrease the incidence rate of cerebral venous air embolisms, we presently described a ... [more ▼]

The sitting position is considered as a gold standard for posterior fossa surgical procedures. However, in order to decrease the incidence rate of cerebral venous air embolisms, we presently described a modified supine position allowing performance of posterior fossa surgical procedures. Such position is easy and quickly performed with light variations of blood pressure: patients are placed supine with paddings inserted under ipsilateral shoulder and buttock, and head turned to other side of surgical site. Dural tension estimated by the surgeon was always considered as good. We performed more than 100 surgical procedures in this position without any complication for 10 years. [less ▲]

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See detailNumerical modelling of two-way reinforced concrete slabs in fire
Lim, Linus; Buchanan, Andrew; Moss, Peter et al

in Engineering Structures (2004), 26(8), 1081-1091

This paper describes numerical modelling of the fire behaviour of two-way reinforced concrete slabs using a special purpose non-linear finite-element program, SAFIR. Several two-way reinforced concrete ... [more ▼]

This paper describes numerical modelling of the fire behaviour of two-way reinforced concrete slabs using a special purpose non-linear finite-element program, SAFIR. Several two-way reinforced concrete and composite steel-concrete slabs are tested under exposure to the ISO standard fire in order to validate the shell finite element in the SAFIR program. The modelling results showed agreement with the fire tests and demonstrate that the SAFIR shell element can be used to predict tensile membrane behaviour of two-way reinforced concrete slabs in fire conditions. The analyses show that two-way slabs have excellent fire resistance if they deform in double curvature and develop tensile membrane action. (C) 2004 Elsevier Ltd. All rights reserved. [less ▲]

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See detailPrevalence and demographic features of childhood growth hormone deficiency in Belgium during the period 1986-2001
Thomas, Muriel; Massa, Guy; Craen, Margarita et al

in European Journal of Endocrinology (2004), 151(1), 67-72

Objective: Since the availability of recombinant human growth hormone (rhGH) all children with growth hormone deficiency (GHD) living in Belgium are offered rhGH treatment after approval by a peer-review ... [more ▼]

Objective: Since the availability of recombinant human growth hormone (rhGH) all children with growth hormone deficiency (GHD) living in Belgium are offered rhGH treatment after approval by a peer-review board. In this study, we evaluated the prevalence and demographic features of childhood GHD in Belgium during the period 1986-2001 and we compared them with the data from other countries. Methods: Diagnostic, demographic and baseline auxological data of 714 children diagnosed as having GHD between 1986 and 2001 were retrieved from the database of the Belgian Study Group for Paediatric Endocrinology. Results: The prevalence of GHD in Belgium was estimated to be 1/5600. The origin of GHD was idiopathic (idGHD) in 41% of the patients, congenital (congGHD) in 20% and acquired (acqGHD) in 35%. During the first 4 years (1986-1989) more patients were classified as idGHD; thereafter the distribution between the three aetiology groups did not change. In all groups, boys outnumbered girls but this preponderance was especially pronounced in congGHD patients (male:female = 4:1) with a central malformation that associates an anterior pituitary hypoplasia, a missing, fine or normal pituitary stalk and an ectopic posterior pituitary. Thirteen percent of the patients with idGHD, 50% with congGHD and 52% with acqGHD had multiple pituitary deficiencies. Patients with congGHD were the youngest (mean+/-S.D. age: 6.5+/-4.7 years) and were the shortest (-3.0+/-1.3 standard deviation score (SDS)) at the start of rhGH treatment. There was no time trend over the studied period for age and height at onset of GH therapy. Conclusion: In Belgium, the prevalence of childhood GHD can be estimated as 1/5600 which is comparable to other recent surveys. The yearly number of new patients for the different aetiologies and the auxological parameters have remained relatively constant over the last 16 years. [less ▲]

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See detailPhase I/II trial of immunogenicity of a human papillomavirus (HPV) type 16 E7 protein-based vaccine in women with oncogenic HPV-positive cervical intraepithelial neoplasia
Hallez, Sophie; Simon, Philippe; Maudoux, Frédéric et al

in Cancer Immunology, Immunotherapy (2004), 53(7), 642-650

Purpose: Infection with oncogenic human papillomavirus (HPV) and HPV-16 in particular is a leading cause of anogenital neoplasia. High-grade intraepithelial lesions require treatment because of their ... [more ▼]

Purpose: Infection with oncogenic human papillomavirus (HPV) and HPV-16 in particular is a leading cause of anogenital neoplasia. High-grade intraepithelial lesions require treatment because of their potential to progress to invasive cancer. Numerous preclinical studies have demonstrated the therapeutic potential of E7-directed vaccination strategies in mice tumour models. In the present study, we tested the immunogenicity of a fusion protein (PD-E7) comprising a mutated HPV-16 E7 linked to the first 108 amino acids of Haemophilus influenzae protein D, formulated in the GlaxoSmithKline Biologicals adjuvant AS02B, in patients bearing oncogenic HPV-positive cervical intraepithelial neoplasia (CIN). Methods: Seven patients, five with a CIN3 and two with a CIN1, received three intramuscular injections of adjuvanted PD-E7 at 2-week intervals. Three additional CIN1 patients received a placebo. CIN3 patients underwent conization 8 weeks postvaccination. Cytokine flow cytometry and ELISA were used to monitor antigen-specific cellular and antibody responses from blood taken before and after vaccine or placebo injection. Results: Some patients had preexisting systemic IFN-gamma CD4(+) (1/10) and CD8(+) (5/10) responses to PD-E7. Vaccination, not placebo injection, elicited systemic specific immune responses in the majority of the patients. Five vaccinated patients (71%) showed significantly increased IFN-gamma CD8(+) cell responses upon PD-E7 stimulation. Two responding patients generated long-term T-cell immunity toward the vaccine antigen and E7 as well as a weak H. influenzae protein D (PD)-directed CD4(+) response. All the vaccinated patients, but not the placebo, made significant E7- and PD-specific IgG. Conclusions: The encouraging results obtained from this study performed on a limited number of subjects justify further analysis of the efficacy of the PD-E7/AS02B vaccine in CIN patients. [less ▲]

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See detailY a-t-il une ritualité initiatique et des rites de passage pour les adolescents de nos sociétés occidentales contemporaines?
Stassart, Martine ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (2004), 42

All societies are concerned on a highest point with getting over from childhood to adulthood. The socalled primitive people solved that problem through ritual initiation which is identically organized by ... [more ▼]

All societies are concerned on a highest point with getting over from childhood to adulthood. The socalled primitive people solved that problem through ritual initiation which is identically organized by the various "primitive" cultures. Is there an equivalent of that process in the modern western culture? [less ▲]

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See detailReduction of apoptosis and proliferation in endometriosis
Beliard, Aude ULg; Noël, Agnès ULg; Foidart, Jean-Michel ULg

in Fertility and Sterility (2004), 82(1), 80-85

Objective: To evaluate whether endometriosis could be related to an impaired balance between apoptosis and proliferation, two processes which could be modulated by hormonal status. Design ... [more ▼]

Objective: To evaluate whether endometriosis could be related to an impaired balance between apoptosis and proliferation, two processes which could be modulated by hormonal status. Design: Immunohistochemical study. Setting: Academic research laboratory. Intervention(s): Endometriotic samples obtained from peritoneum of women aged 26-40 years who were undergoing laparoscopy for pain or infertility. Main Outcome Measure(s): Apoptotic cells were detected with the use of the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay. The production of p53 and bcl-2, estrogen and Progesterone (P) receptors, and cellular proliferation were assessed by immunohistochemistry in eutopic and ectopic endometria from 30 patients with endometriosis throughout the menstrual cycle. Results were compared with those from normal endometria from 15 fertile patients. Result(s): Endometriotic lesions were characterized by reduced TUNEL and p53 stainings and by enhanced bcl-2 staining. No correlation between apoptosis and estrogen receptor or P receptor levels was found. A lower amount of steroid receptor was found in endometriotic tissues, without cyclic modulation, compared with the eutopic endometrium. Conclusion(s): Our results suggest that when endometrial tissue is located at ectopic locations, it differs from eutopic endometrium by its proliferation rate, steroid hormone levels, and markers of apoptosis. A reduced sensitivity of endometriotic cells to apoptosis could promote the dissemination and implantation of these cells to ectopic sites. (C) 2004 by American Society for Reproductive Medicine. [less ▲]

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See detailEstrogens and pain : a study in aromatase knock-out mice using the formalin model
Multon, Sylvie ULg; Mosen, Jeanine; Wouters, Murielle ULg et al

Poster (2004, July)

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See detailTime dependent risk of gastrointestinal complications induced by non-steroidal anti-inflammatory drug use: a consensus statement using a meta-analytic approach
Richy, F.; Bruyère, Olivier ULg; Ethgen, Olivier ULg et al

in Annals of the Rheumatic Diseases (2004), 63(7), 759-766

OBJECTIVES: To provide an updated document assessing the global, NSAID-specific, and time dependent risk of gastrointestinal (GI) complications through meta-analyses of high quality studies. METHODS: An ... [more ▼]

OBJECTIVES: To provide an updated document assessing the global, NSAID-specific, and time dependent risk of gastrointestinal (GI) complications through meta-analyses of high quality studies. METHODS: An exhaustive systematic search was performed. Inclusion criteria were: RCT or controlled study, duration of 5 days at least, inactive control, assessment of minor or major NSAID adverse effects, publication range January 1985 to January 2003. The publications retrieved were assessed during a specifically dedicated WHO meeting including leading experts in all related fields. Statistics were performed conservatively. Meta-regression was performed by regressing NSAID adjusted estimates against study duration categories. RESULTS: Among RCT data, indolic derivates provided a significantly higher risk of GI complications related to NSAID use than for non-users: RR = 2.25 (1.00; 5.08) than did other compounds: naproxen: RR = 1.83 (1.25; 2.68); diclofenac: RR = 1.73 (1.21; 2.46); piroxicam: RR = 1.66 (1.14; 2.44); tenoxicam: RR = 1.43 (0.40; 5.14); meloxicam: RR = 1.24 (0.98; 1.56), and ibuprofen: RR = 1.19 (0.93; 1.54). Indometacin users had a maximum relative risk for complication at 14 days. The other compounds presented a better profile, with a maximum risk at 50 days. Significant additional risk factors included age, dose, and underlying disease. The controlled cohort studies provided higher estimates: RR = 2.22 (1.7; 2.9). Publication bias testing was significant, towards a selective publication of deleterious effects of NSAIDs from small sized studies. CONCLUSION: This meta-analysis characterised the "compound" and "time" aspects of the GI toxicity of non-selective NSAIDs. The risk/benefit ratio of such compounds should thus be carefully and individually evaluated at the start of long term treatment. [less ▲]

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See detailLes stations de pompage du bassin liégeois, un patrimoine architectural méconnu
Charlier, Sébastien ULg

in Nouvelles du Patrimoine (Les) (2004), 105

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See detailAnti-IgE: a significant breakthrough in the treatment of airway allergic diseases
Louis, Renaud ULg

in Allergy (2004), 59(7), 698-700

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See detailAllogeneic stem cell transplantation in acute lymphoblastic leukemia and non-Hodgkin's lymphoma for patients <= 50 years old in first complete remission: results of the EORTC ALL-3 trial
Labar, Boris; Suciu, Stefan; Zittoun, Robert et al

in Haematologica (2004), 89(7), 809-817

Background and Objectives. In the EORTC ALL-3 trial, the efficacy of allogeneic transplantation was compared with that of autologous marrow transplantation and maintenance chemotherapy in patients less ... [more ▼]

Background and Objectives. In the EORTC ALL-3 trial, the efficacy of allogeneic transplantation was compared with that of autologous marrow transplantation and maintenance chemotherapy in patients less than or equal to 50 years who reached CR. Design and Methods. Among 340 patients who entered the study, 279 were less than or equal to 50 years old. Out of these, 220 reached CR, 184 patients started consolidation and were HLA typed; 68 had a donor and 116 had no sibling donor. The median follow-up was 9.5 years; 93 patients relapsed, 26 died in CR, and overall 116 patients died. Allogeneic transplantation was performed in 47 (68%) patients with a donor while autologous transplantation or maintenance chemotherapy was given to 84 (72%) patients without a sibling donor. Results. The 6-year disease-free survival rate was similar in the groups with and without donor [38.2% (SE=5.9%) vs. 36.8% (SE=4.6%), hazard ratio 1.01, 95% CI 0.67-1.53]. Comparing the donor group with the no donor group, the former had a lower relapse incidence (38.2% vs. 56.3%, p=0.001), but a higher cumulative incidence of death in CR (23.5% vs. 6.9%, p=0.0004). The 6-year survival rates were similar [41.2% (SE=6.0%) vs. 38.8% (SE=4.6%)]. Interpretation and Conclusions. This trial did not show that allogeneic transplantation, when a sibling donor is available, produces a better outcome than the policy of offering autotransplantation or chemotherapy in the absence of a donor. [less ▲]

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