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See detailCalculul Constructiilor Metalice la Actiunea Focului
Franssen, Jean-Marc ULg; Zaharia, Raul

Book published by Editura Orizonturi Universitare (2008)

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See detailFitness And Genetic Variation Of Viola Calaminaria, An Endemic Metallophyte: Implications Of Population Structure And History
Bizoux, Jean-Philippe ULg; Daïnou, Kasso ULg; Raspe, O. et al

in Plant Biology (2008), 10(6), 684-693

We investigated variations in genetic diversity and plant fitness in a rare endemic metallophyte of calamine soils, Viola calaminaria, in relation to population size, population connectivity and ... [more ▼]

We investigated variations in genetic diversity and plant fitness in a rare endemic metallophyte of calamine soils, Viola calaminaria, in relation to population size, population connectivity and population history in order to evaluate and discuss potential conservation strategies for the species. Mean population genetic diversity (Hs = 0.25) of V. calaminaria was similar to endemic non-metallophyte taxa. Twenty-one per cent of the genetic variation was partitioned among populations and a low (9%) but significant differentiation was found among geographical regions. Our results did not support the hypothesis that the acquisition of metal tolerance may result in reduced genetic diversity, and suggested that strict metallophytes do not exhibit higher inter-population differentiation resulting from scattered habitats. There were no relationships between population genetic diversity and population size. Significant correlations were found between plant fitness and (i) population size and (ii) connectivity index. Recently-founded populations exhibited the same level of genetic diversity as ancient populations and also possessed higher plant fitness. There was no indication of strong founder effects in recently-established populations. The results suggest that the creation of habitats through human activities could provide new opportunities for conservation of this species. [less ▲]

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See detailCharacterization of the tropospheric small-scale activity
Brenot, Hugues; Warnant, René ULg

Report (2008)

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See detailCommunication as a sign of adaptation to a complex system: The case of robotic surgery
Nyssen, Anne-Sophie ULg; Blavier, Adelaïde ULg

in Nemeth, C. (Ed.) Improving Healthcare Team Communication: Building on Lessons from Aviation and Aerospace (2008)

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See detailL'héritage des études sociales de l'objet dans l'action
Melard, François ULg

in Melard, François (Ed.) Écologisation : Objets et concepts intermédiaires (2008)

Ce chapitre introductif vise à présenter une série de perspectives de recherche associées à l'étude des objets et dispositifs socio-techniques selon leurs modes d'engagement dans l'action : l'objet ... [more ▼]

Ce chapitre introductif vise à présenter une série de perspectives de recherche associées à l'étude des objets et dispositifs socio-techniques selon leurs modes d'engagement dans l'action : l'objet "transparent", l'objet "média" ou encore l'objet "médiateur". [less ▲]

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See detailDébats belges pour une politique migratoire. Mapping des acteurs
Perrin, Nathalie ULg; Stockmans, Pieter

Book published by Fondation Roi Baudouin (2008)

Cette publication propose un inventaire des principaux acteurs qui contribuent ou peuvent contribuer à définir une politique migratoire pour la Belgique ; elle fait aussi le point sur leurs prises de ... [more ▼]

Cette publication propose un inventaire des principaux acteurs qui contribuent ou peuvent contribuer à définir une politique migratoire pour la Belgique ; elle fait aussi le point sur leurs prises de position récentes. Quel est par exemple le point de vue de la FGTB sur une régularisation ? Que pense la FEB d’une nouvelle migration économique ? Que dit le Conseil des Femmes sur l’accueil des primo-arrivants ? Et bien d’autres encore. [less ▲]

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See detailCognition sociale
Dardenne, Benoît ULg

in van Zanten, Agnès (Ed.) Dictionnaire de l'éducation (2008)

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See detailNORINE: a database of nonribosomal peptides.
Caboche, Segolene; Pupin, Maude; Leclere, Valerie et al

in Nucleic acids research (2008), 36(Database issue), 326-31

Norine is the first database entirely dedicated to nonribosomal peptides (NRPs). In bacteria and fungi, in addition to the traditional ribosomal proteic biosynthesis, an alternative ribosome-independent ... [more ▼]

Norine is the first database entirely dedicated to nonribosomal peptides (NRPs). In bacteria and fungi, in addition to the traditional ribosomal proteic biosynthesis, an alternative ribosome-independent pathway called NRP synthesis allows peptide production. It is performed by huge protein complexes called nonribosomal peptide synthetases (NRPSs). The molecules synthesized by NRPS contain a high proportion of nonproteogenic amino acids. The primary structure of these peptides is not always linear but often more complex and may contain cycles and branchings. In recent years, NRPs attracted a lot of attention because of their biological activities and pharmacological properties (antibiotic, immunosuppressor, antitumor, etc.). However, few computational resources and tools dedicated to those peptides have been available so far. Norine is focused on NRPs and contains more than 700 entries. The database is freely accessible at http://bioinfo.lifl.fr/norine/. It provides a complete computational tool for systematic study of NRPs in numerous species, and as such, should permit to obtain a better knowledge of these metabolic products and underlying biological mechanisms, and ultimately to contribute to the redesigning of natural products in order to obtain new bioactive compounds for drug discovery. [less ▲]

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See detailÉtudes régionales et fédérales : nouvelles perspectives
Dandoy, Régis; Perrin, Nathalie ULg; Van Wynsberghe, Caroline

in Fédéralisme - Régionalisme (2008), 8(2),

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See detailVers un renouveau des études régionales et fédérales ? Un panorama d’approches politologiques contemporaines
Dandoy, Régis; Van Wynsberghe, Caroline; Perrin, Nathalie ULg

in Fédéralisme - Régionalisme (2008), 8(2),

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See detailThe neglected intrinsic resistome of bacterial pathogens.
Fajardo, Alicia; Martinez-Martin, Nadia; Mercadillo, Maria et al

in PloS one (2008), 3(2), 1619

Bacteria with intrinsic resistance to antibiotics are a worrisome health problem. It is widely believed that intrinsic antibiotic resistance of bacterial pathogens is mainly the consequence of cellular ... [more ▼]

Bacteria with intrinsic resistance to antibiotics are a worrisome health problem. It is widely believed that intrinsic antibiotic resistance of bacterial pathogens is mainly the consequence of cellular impermeability and activity of efflux pumps. However, the analysis of transposon-tagged Pseudomonas aeruginosa mutants presented in this article shows that this phenotype emerges from the action of numerous proteins from all functional categories. Mutations in some genes make P. aeruginosa more susceptible to antibiotics and thereby represent new targets. Mutations in other genes make P. aeruginosa more resistant and therefore define novel mechanisms for mutation-driven acquisition of antibiotic resistance, opening a new research field based in the prediction of resistance before it emerges in clinical environments. Antibiotics are not just weapons against bacterial competitors, but also natural signalling molecules. Our results demonstrate that antibiotic resistance genes are not merely protective shields and offer a more comprehensive view of the role of antibiotic resistance genes in the clinic and in nature. [less ▲]

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See detailWiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis
Meyer-Bahlburg, A.; Becker-Herman, S.; Humblet, Stéphanie ULg et al

in Blood (2008), 112(10), 4158-69

To more precisely identify the B-cell phenotype in Wiskott-Aldrich syndrome (WAS), we used 3 distinct murine in vivo models to define the cell intrinsic requirements for WAS protein (WASp) in central ... [more ▼]

To more precisely identify the B-cell phenotype in Wiskott-Aldrich syndrome (WAS), we used 3 distinct murine in vivo models to define the cell intrinsic requirements for WAS protein (WASp) in central versus peripheral B-cell development. Whereas WASp is dispensable for early bone marrow B-cell development, WASp deficiency results in a marked reduction in each of the major mature peripheral B-cell subsets, exerting the greatest impact on marginal zone and B1a B cells. Using in vivo bromodeoxyuridine labeling and in vitro funtcional assays, we show that these dificits reflect altered peripheral homeostasis, partially resulting from an impairment in integrin function, rather than a developmental defect. Consistent with these observations, we also show that : (1) WASp expression levels increase with cell maturaity, peaking in those subsets exhibiting the greatest sensitivity to WASp deficiency; (2) WASp+ murine B cells exhibit a marked selective advantage beginning at the late transitional B-cell stage; and (3) a similar in vivo selective advantage is manifest by mature WASp+ human B cells. Together, our data provide a better understanding of the clinical phenotype of WAS and suggest that gene therapy might be a useful approach to rescue altered B-cell homeostasis in this disease. [less ▲]

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See detailValidation of a nonaqueous capillary electrophoretic method for the enantiomeric purity determination of R-flurbiprofen using a single-isomer amino cyclodextrin derivative
Rousseau, Anne ULg; Chiap, Patrice ULg; Ivanyi, Robert et al

in Journal of Chromatography. A (2008), 1204(2), 219-225

Nonaqueous capillary electrophoresis (NACE) was successfully applied to the enantiomeric purity determination of R-flurbiprofen using 6-monodeoxy-6-mono(2-hydroxy)propylamino-beta-cyclodextrin (IPA-beta ... [more ▼]

Nonaqueous capillary electrophoresis (NACE) was successfully applied to the enantiomeric purity determination of R-flurbiprofen using 6-monodeoxy-6-mono(2-hydroxy)propylamino-beta-cyclodextrin (IPA-beta-CD) as chiral selector. The nonaqueous BGE was made up of 20 mM IPA-beta-CD, 20 mM ammonium camphorsulfortate and 40 mM ammonium acetate in methanol. Flufenamic acid was selected as internal standard. The CE method was carefully optimized in order to prevent the adsorption of the cationic CD onto the capillary wall, and therefore, to avoid loss of peak efficiency and enantioresolution. To achieve this goal, the addition of ammonium camphorsulfonate was found to be necessary. In the selected conditions, the determination of 0.1% of S-flurbiprofen in R-flurbiprofen could be performed using the method of standard additions. The NACE method was then fully validated by applying a novel strategy using accuracy profiles. (c) 2008 Elsevier B.V. All rights reserved. [less ▲]

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See detailDCDS - Distant Collaborative Design Studio. An Initial Experimentation in Distant Collaborative Design Studio in Architecture.
Elsen, Catherine ULg; Juchmes, Roland ULg; Kubicki, Sylvain et al

in Muylle, Marc (Ed.) Architecture "in computero", Integrating Methods and Techniques. Proceedings of the 26th eCAADe Conference on Education and Research in Computer Aided Architectural Design in Europe. (2008)

This paper introduces new supporting tools in the field of distant collaborative design, namely DCDS and CRTI-weB. These prototypes respectively support: the early stages of design, through the support of ... [more ▼]

This paper introduces new supporting tools in the field of distant collaborative design, namely DCDS and CRTI-weB. These prototypes respectively support: the early stages of design, through the support of the crucial initial step of free-hand sketches shared in real-time, and the asynchronous collaborative activities. The main goal of this paper is to propose the use of these innovative tools as an efficient and realistic way of managing long distance collaboration, to effectively serve the designers’ needs. This proposition is analyzed and questioned through a real-size experiment featuring 30 architecture and architectural-engineering students, working together in real-time in different locations (Belgium and France). This experiment and the necessary survey open up interesting fields of investigation, such as the relevance of the proposed devices in supporting distant collaborative design in architecture and the benefit this represents for students to merge the IT aspects and the design studio. The methodology and the replicability are analyzed to increase the level and quality of formation of our students and, finally, a critique of the tools confirms a benefit for the developing teams. [less ▲]

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See detailAn unusual diagnosis of a bicornuate unicollis uterus
Panayotidis, Costas; Foidart, Jean-Michel ULg; Nisolle, Michelle ULg

in Gynecological Surgery (2008), 5(1), 57-60

We present a case of an unusual diagnosis of a bicornuate unicollis uterus mimicking a uterus didelphys with blind hemivagina. Few cases of a bicornuate uterus have been reported with the primary symptom ... [more ▼]

We present a case of an unusual diagnosis of a bicornuate unicollis uterus mimicking a uterus didelphys with blind hemivagina. Few cases of a bicornuate uterus have been reported with the primary symptom of a paracervical pyocolpos. The difficulties involved in the diagnosis and management of this particular congenital malformation are described in detail. The role of imaging techniques and adequate preoperative preparation is emphasised with a review of recent literature [less ▲]

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See detailPersistence of an intact endometrial matrix and vessels structure in women exposed to VA-2914, a selective progesterone receptor modulator.
Ravet, Stéphanie ULg; Munaut, Carine ULg; Blacher, Silvia ULg et al

in Journal of Clinical Endocrinology and Metabolism (2008), 93(11), 4525-31

Background: VA-2914 is a selective progesterone receptor modulator with potential contraceptive activity that induces amenorrhea, whereas progestins cause endometrial spotting and bleeding. This abnormal ... [more ▼]

Background: VA-2914 is a selective progesterone receptor modulator with potential contraceptive activity that induces amenorrhea, whereas progestins cause endometrial spotting and bleeding. This abnormal bleeding due to progestins is a consequence of focal stromal proteolysis by an increase in naked vessel size and density. Objective: Our objective was to quantify the effects of VA-2914 on endometrial vascularization, fibrillar matrix, and vascular endothelial growth factor (VEGF)-A expression in endometrial biopsies from 41 women before and after 12 wk daily treatment with a placebo, or 2.5, 5, or 10 mg VA-2914. Methods: Collagen fibrillar network was stained by silver impregnation. Vessel area, density, and structure were quantified with a computer-assisted image analysis system after double immunostaining using an anti-von Willebrand factor (endothelial cells) and an anti- smooth muscle actin (vascular smooth muscle cells) marker antibody. VEGF-A mRNAs were quantified by RT-PCR and localized by immunohistochemistry. Results: The endometrial vessels, collagen network, and mRNA levels of VEGF-A were identical during the luteal phase at baseline and in VA-2914 treated women. VEGF-A distribution was unchanged. Conclusions: VA-2914 does not alter the endometrial matrix and cells, and does not modify the endometrial vessel morphology as compared with baseline biopsies. [less ▲]

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See detailWhen HIV gets into the brain
Cuvelier, Marie-Laure ULg; Leonard, Philippe ULg; Rikir, Estelle ULg et al

in Revue Médicale de Liège (2008), 63(5-6), 338-341

Besides opportunistic infections, direct or indirect HIV-mediated lesions of cerebral vascular or neural cells can also occur during the natural course of HIV infection. The main non-infectious ... [more ▼]

Besides opportunistic infections, direct or indirect HIV-mediated lesions of cerebral vascular or neural cells can also occur during the natural course of HIV infection. The main non-infectious complications of HIV are cerebral lymphomas, cerebrovascular disorders, HIV dementia and myelitis. [less ▲]

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See detailMulti-Step toolpath approach to overcome forming limitations in single point incremental forming
Verbert, J.; Belkassem, B.; Henrard, Christophe ULg et al

in Boisse, P. (Ed.) Proceedings of the 11th International ESAFORM Conference on Material Forming (2008)

Although Incremental Forming offers distinct advantages over traditional forming processes, such as short lead times and low setup costs, the process still has some drawbacks. Besides the obtainable ... [more ▼]

Although Incremental Forming offers distinct advantages over traditional forming processes, such as short lead times and low setup costs, the process still has some drawbacks. Besides the obtainable accuracy, one of the main challenges of the process are the process limits. Many workpiece geometries cannot be manufactured due to the fact that the maximum wall angle that can be formed is limited for a certain sheet material and thickness to a given angle. Different solutions to this approach have been proposed and this paper further investigates one of those solutions, the multi step approach for single point incremental forming. Experiments were performed and compared with simulations to better understand the phenomena underlying the improved process performance. [less ▲]

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See detailHIV-related infections of the brain
Cuvelier, Marie-Laure ULg; Leonard, Philippe ULg; Rikir, Estelle ULg et al

in Revue Médicale de Liège (2008), 63(5-6), 342-348

During the natural course of human immunodeficiency virus infection, central nervous system insults are very common. They can consist of infectious complications, consequently to the collapse of the ... [more ▼]

During the natural course of human immunodeficiency virus infection, central nervous system insults are very common. They can consist of infectious complications, consequently to the collapse of the patient's immune system. Alternatively, direct or indirect HIV-mediated lesions of cerebral vascular or neural cells can also occur. It is crucial to detect HIV-related infectious complications since their prognosis will depend on early and accurate treatments. The diagnosis is generally made by means of magnetic resonance imaging and lumbar puncture. [less ▲]

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