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See detailEffects of endotoxic shock on right ventricular systolic function and mechanical efficiency
Lambermont, Bernard ULg; Ghuysen, Alexandre ULg; Kolh, Philippe ULg et al

in Cardiovascular Research (2003), 59(2), 412-418

Objective: To investigate the effects of endotoxin infusion on right ventricular (RV) systolic function and mechanical efficiency. Methods: Six anesthetized pigs (Endo group) received a 0.5 mg/kg ... [more ▼]

Objective: To investigate the effects of endotoxin infusion on right ventricular (RV) systolic function and mechanical efficiency. Methods: Six anesthetized pigs (Endo group) received a 0.5 mg/kg endotoxin infusion over 30 min and were compared with six other anesthetized pigs (Control group) receiving placebo for 5 h. RV pressure-volume (PV) loops were obtained by the conductance catheter technique and pulmonary artery flow and pressure were measured with high-fidelity transducers. Results: RV adaptation to increased afterload during the early phase of endotoxin-induced pulmonary hypertension (T30) was obtained by both homeometric and hetereometric regulations: the slope of the end-systolic PV relationship of the right ventricle increased from 1.4+/-0.2 mmHg/ml to 2.9+/-0.4 mmHg/ml (P<0.05) and RV end-diastolic volume increased from 56+/-6 ml to 64+/-11 ml (P<0.05). Consequently, right ventricular-vascular coupling was maintained at a maximum efficiency. Ninety minutes later (T120), facing the same increased afterload, the right ventricle failed to maintain its contractility to such an elevated level and, as a consequence, right ventricular-vascular uncoupling occurred. PV loop area, which is known to be highly correlated with oxygen myocardial consumption, increased from 1154+/-127 mmHg/ml (T0) to 1798+/-122 mmHg/ml (T180) (P<0.05) while RV mechanical efficiency decreased from 63+/-2% (T0) to 45+/-5% (T270) (P<0.05). Conclusions: In the very early phase of endotoxinic shock, right ventricular-vascular coupling is preserved by an increase in RV contractility. Later, myocardial oxygen consumption and energetic cost of RV contractility are increased, as evidenced by the decrease in RV efficiency, and right ventricular-vascular uncoupling occurs. Therefore, therapies aiming at restoring right ventricular-vascular coupling in endotoxic shock should attempt to increase RV contractility and to decrease RV afterload but also to preserve RV mechanical efficiency. (C) 2003 European Society of Cardiology. Published by Elsevier B.V. All rights reserved. [less ▲]

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See detailFavourable outcome of a brain trauma patient despite bilateral loss of cortical somatosensory evoked potential during thiopental sedation
Robe, Pierre; Dubuisson, Annie ULg; Bartsch, Sébastien et al

in Journal of Neurology, Neurosurgery & Psychiatry (2003), 74(8), 1157-1158

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See detailAn efficient decentralized on-line traffic engineering algorithm for MPLS networks
Blanchy, François; Mélon, Laurent; Leduc, Guy ULg

in Providing Quality of Service in Heterogeneous Environments (2003, August)

Multi-Protocol Label Switching (MPLS) provides ways to control the Label Switched Paths (LSPs) followed by traffic trunks in a network and thereby to better traffic engineer it. In this context, we look ... [more ▼]

Multi-Protocol Label Switching (MPLS) provides ways to control the Label Switched Paths (LSPs) followed by traffic trunks in a network and thereby to better traffic engineer it. In this context, we look at the problem of organizing the mapping of LSPs in an optimal way throughout the network on the basis of a given objective function. This problem is highly combinatorial and makes dynamic and real-time features a difficult issue for any LSP routing scheme. For this reason, we propose a computationally efficient, though approximate, on-line scheme adapted to an incremental optimization of the network state. It is then applied to a seldom mentioned traffic engineering problem: the compromise between load-balancing and traffic minimization. It is expected that clever routing strategies to balance the network load will sometimes favor longer paths in order to avoid congestion, leading to an increase of the overall network utilization. This reasoning is confirmed by our study, and we show that an improvement in network management can be made by appropriately tuning this compromise. [less ▲]

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See detailCrystal structure of Enterobacter cloacae 908R class C beta-lactamase bound to iodo-acetamido-phenyl boronic acid, a transition-state analogue
Wouters, J.; Fonze, E.; Vermeire, M. et al

in Cellular and Molecular Life Sciences (2003), 60(8), 1764-1773

The structures of the, class C beta-lactamase from Enterobacter cloacae 908R alone and in complex with a baronic acid transition-state analogue were determined by X-ray crystallography at 2.1 and 2.3 ... [more ▼]

The structures of the, class C beta-lactamase from Enterobacter cloacae 908R alone and in complex with a baronic acid transition-state analogue were determined by X-ray crystallography at 2.1 and 2.3 Angstrom, respectively. The structure of the enzyme resembles those of other class C beta-lactamases. The structure of the. complex with the transition-state analogue, iodo-acetamido-phenyl boronic acid, shows that the inhibitor is covalently, bound to the active-site serine (Ser64). Binding of the inhibitor within the active site is compared with previously determined structures of complexes with other class C enzymes. The structure of the boronic acid adduct indicates ways to improve the affinity of this class of inhibitors. This structure of 908R class C beta-lactamase in complex with a transitionstate analogue provides further insights into the mechanism of action of these hydrolases. [less ▲]

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See detailGuidelines for percutaneous coronary intervention by the Belgian Working Group on Invasive Cardiology
Legrand, Victor ULg; Wijns, W.; Vandenbranden, F. et al

in Acta Cardiologica (2003), 58(4), 341-348

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See detailFaunal/floral and isotopic responses to Milankovitch precession cycles and environmental changes in the upper Gulpen Formation (Upper Maastrichtian) at the CBR-Lixhe and ENCI-Maastricht bv quarries
Felder, P. J.; Keppens, E.; De Clercq, Bernadette ULg et al

in Netherlands Journal of Geosciences-Geologie en Mijnbouw (2003), 82(3), 275-281

Two sections, just below the Nivelle Horizon in the upper Gulpen Formation (Upper Maastrichtian), and seven kilometres apart (CBR-Lixhe and ENCI-Maastricht bv quarries) have been analysed (samples every 5 ... [more ▼]

Two sections, just below the Nivelle Horizon in the upper Gulpen Formation (Upper Maastrichtian), and seven kilometres apart (CBR-Lixhe and ENCI-Maastricht bv quarries) have been analysed (samples every 5 cm) for dinocyst, pollen grains and bioclast contents as well as for carbon and oxygen isotopic composition, to obtain better insight into the influence of weathering on these sediments. The CBR section lies above groundwater level, while that at the ENCI quarry is some metres below. At the former quarry we recognised the influences of weathering (karst) nearby. At ENCI, palynological, bioclast and stable isotope results of the carbonate phase (mainly consisting of coccoliths) co-vary remarkably, displaying two cycles which may be interpreted tentatively as climatic fluctuations. The partial derivative(18)O curve varies roughly between -1.6parts per thousand and -1.1parts per thousand (on PDB scale), corresponding to a temperature change of about 2degreesC. Less negative values (i.e. cooler seawater) coincide with larger amounts of pollen of Normapolles and Triporates type assumed to represent temperate forest elements of a vegetation also containing tropical elements such as palms. Assuming the 5 cm sample intervals at ENCI to correspond to 1 ka, climatic maxima (and minima) may be 20-25 ka apart, obviously recalling Milankovitch precession cycles. These are independent of a sharp sedimentological change noted in the upper part of the lowest cycle (samples 42 to 24). Upwards of sample 42, bioclast contents increase and dinocysts, Spiniferites in particular, decrease significantly, corresponding to a marked shallowing. This turning point is also recorded in the partial derivative(13)C curve at ENCI. Bioclast percentages appear to follow composite trends that are influenced by both climatic and sedimentological conditions. [less ▲]

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See detailPredictors of early and late outcome of percutaneous coronary intervention in octogenarians
Gach, Olivier ULg; Louis, Olivier ULg; Martinez, Christophe ULg et al

in Acta Cardiologica (2003), 58(4), 289-294

Objective To evaluate the short and long-term results of percutaneous coronary interventions (PCI) in patients aged 80 years or older and to identify predictors of event-free survival. Methods and results ... [more ▼]

Objective To evaluate the short and long-term results of percutaneous coronary interventions (PCI) in patients aged 80 years or older and to identify predictors of event-free survival. Methods and results - Clinical and angiographic data from all patients undergoing percutaneous coronary intervention in our institution are prospectively collected and stored in a computerized database. The clinical and angiographic characteristics of all patients aged 80 years or older undergoing percutaneous coronary intervention between January 1994 and December 1999 were analysed retrospectively. Follow-up was obtained by interview or through the referring physician. One hundred and fifty-eight patients aged 80 years or older (median: 83.4; range: 80.2-92.2) underwent percutaneous coronary intervention in our institution during the study period. The initial angiographic success rate was 92%. In-hospital mortality was 8.2% and procedural success 84.8%. One-year and two-year survival were 81% and 72.2% respectively, while event free survival at 1 year and 2 years was 65.8% and 57%. Using the Cox proportional hazards method, we identified incomplete revascularization and low left ventricular ejection fraction (WEF) as predictors of death at 2 years. Complete revascularization and stenting were independent predictors of 2-year event-free survival. Conclusion - Percutaneous coronary intervention can be performed safely in octogenarians. Complete revascularization, stenting and preserved left ventricular ejection fraction were independent predictors of better outcome in this population. [less ▲]

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See detailThe double dividend of postponing retirement
Cremer, H.; Pestieau, Pierre ULg

in International Tax and Public Finance (2003), 10(4), 419-434

Early retirement seems to plague social security systems in a number of European countries. In this paper we argue that delaying retirement may have two positive effects: it is likely to partially restore ... [more ▼]

Early retirement seems to plague social security systems in a number of European countries. In this paper we argue that delaying retirement may have two positive effects: it is likely to partially restore the financial balance of the system, and it may foster redistribution among retirees. To obtain such a double dividend, the benefit rule of the initial social security scheme must have the following two characteristics. First, it operates redistribution within generations. Second, it is "biased" and induces early retirement. [less ▲]

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See detailLifting of valid inequalities revisited
Louveaux, Quentin ULg

Conference (2003, August)

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See detailUltimate Strength - Report of ISSC Technical Committee III.1, 2000-2003
Rigo, Philippe ULg; Simonsen B.C et al

in 15th Int. Ship and Offshore Structures Congress, USA, August 2003 (2003)

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See detailTwin pregnancy obtained with frozen-thawed embryos after in vitro maturation in a patient with polycystic ovarian syndrome
Godin, P. A.; Gaspard, Olivier ULg; Thonon, Fabienne ULg et al

in Journal of Assisted Reproduction & Genetics (2003), 20(8), 347-350

Purpose: A twin pregnancy was obtained in a patient with polycystic ovary syndrome after the transfer of three in vitro maturation-derived day 3 embryos that has been frozen and thawed. Methods: The ... [more ▼]

Purpose: A twin pregnancy was obtained in a patient with polycystic ovary syndrome after the transfer of three in vitro maturation-derived day 3 embryos that has been frozen and thawed. Methods: The patient had received mild hMG stimulation followed by hCG injection. After culture for 24 - 48 h, mature oocytes were fertilized by ICSI. Embryos were cultured until day 3; supernumerary embryos were cryopreserved using a slow protocol. Results: Among 15 nonatretic oocytes, 9 matured, 8 were fertilized. Four embryos were transferred but they did not implant. The subsequent transfer of three frozen - thawed embryos resulted in the delivery of two healthy girls. Conclusions: These results indicate that a pregnancy could be obtained with in vitro maturation-derived day-3 frozen - thawed embryos. [less ▲]

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See detailEvidence of a limited contribution of feto-maternal interactions to trophoblast differentiation along the invasive pathway
Goffin, Frédéric ULg; Munaut, Carine ULg; Malassine, A. et al

in Tissue Antigens (2003), 62(2), 104-116

Trophoblast differentiation is a key event in human placental development. During extravillous trophoblast (EVT) differentiation, stem cells from the anchoring villi detach from their basement membrane ... [more ▼]

Trophoblast differentiation is a key event in human placental development. During extravillous trophoblast (EVT) differentiation, stem cells from the anchoring villi detach from their basement membrane and proliferate to form aggregates called trophoblast cell columns (TCCs). They subsequently invade the decidua and differentiate into interstitial and endovascular trophoblasts. The influence of the decidua on EVT differentiation is controversial. We therefore compared the pattern of trophoblast differentiation marker expression in viable intrauterine and tubal pregnancies, as decidual cell markers (prolactin [PRL] and insulin-like growth factor binding Protein-1 [IGFBP1]) were only expressed in endometrial implantation sites. Extravillous trophoblast differentiation in anchoring villi from uterine and ectopic pregnancies exhibited a comparable phenotypical switch: alpha6 integrin subunit, E-cadherin, EGF receptor, Ki 67 and connexin 40 were localized in the proximal part of the TCC, while alpha5beta1 and alpha1 integrins, c-erb B2, hPL and HLA-G were expressed by invasive cytotrophoblasts. The cyclin-dependent kinase inhibitors p16 and p57 were mainly detected in invasive cytotrophoblasts some distance from the columns. However, the TCC was markedly longer in tubal pregnancy than in intrauterine pregnancy. These findings suggest that the decidua is not necessary to trigger EVT invasion, but that it is likely to limit the extent of the TCC and to accelerate the onset of EVT migration. [less ▲]

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See detailReconstructing neutrino properties from collider experiments in a Higgs triplet neutrino mass model
Aristizabal Sierra, Diego ULg; Hirsch, M.; Valle, J. W. F. et al

in Physical Review. D : Particles and Fields (2003), 68

We extend the minimal supersymmetric standard model with bilinear R-parity violation to include a pair of Higgs triplet superfields. The neutral components of the Higgs triplets develop small vacuum ... [more ▼]

We extend the minimal supersymmetric standard model with bilinear R-parity violation to include a pair of Higgs triplet superfields. The neutral components of the Higgs triplets develop small vacuum expectation values (VEVs) quadratic in the bilinear R-parity breaking parameters. In this scheme the atmospheric neutrino mass scale arises from bilinear R-parity breaking while for reasonable values of parameters the solar neutrino mass scale is generated from the small Higgs triplet VEVs. We calculate neutrino masses and mixing angles in this model and show how the model can be tested at future colliders. The branching ratios of the doubly charged triplet decays are related to the solar neutrino angle via a simple formula. [less ▲]

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See detailComprehensive Analysis of PBDEs, PCDD/Fs and PCBs
PIRARD, Catherine ULg; De Pauw, Edwin ULg; Focant, Jean-François ULg

Conference (2003, August)

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