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See detailLe medicament du mois. Insuline glargine (Lantus).
Scheen, André ULg

in Revue Médicale de Liège (2004), 59(2), 110-4

Insulin glargine (Lantus) is a human insulin analogue produced by recombinant DNA technology and recently launched by Aventis. Modification of the human insulin molecule at position A21 and at the C ... [more ▼]

Insulin glargine (Lantus) is a human insulin analogue produced by recombinant DNA technology and recently launched by Aventis. Modification of the human insulin molecule at position A21 and at the C-terminus of the B-chain results in the formation of a stable compound that is soluble at pH 4.0, but forms amorphous microprecipitates in subcutaneous tissue (pH > 7,4) from which small amounts of insulin glargine are gradually released. The plasma concentration versus time profile of insulin glargine is therefore relatively constant over 24 hours as compared to conventional human insulins, especially NPH. This allows once-daily injection as basal insulin therapy, at any moment of the clock time (but if possible at the same time from day to day). Reproducibility of plasma insulin levels is also improved with insulin glargine as compared to human NPH insulin. Insulin glargine administration should be combined to rapid insulin injections, before each meal in order to control postprandial hyperglycaemia, or with oral antidiabetic agents in type 2 diabetes. The pharmacokinetic properties of insulin glargine allow an easier titration of basal insulin dose, which should facilitate adequate blood glucose control while decreasing the risk of hypoglycaemia, especially during night time. Insulin glargine use is safe with no increased antigenicity, immunogenicity or mitogenicity reactions as compared to human insulin. Optimal use of this new insulin analogue should be integrated in a global management of the diabetic patient as well as in a new culture of insulin therapy. [less ▲]

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See detailRegulation of opposition and coeducation within a martial arts school
Lenzen, Benoît; Dejardin, Robert; Cloes, Marc ULg

in STAPS : Revue Internationale des Sciences du Sport et de l'Education Physique (2004), 66

In Japanese martial arts, the regulation of opposition does not lie on impersonal rules as in combat sports. Assuming that a control regulation from the teachers and an autonomous regulation from the ... [more ▼]

In Japanese martial arts, the regulation of opposition does not lie on impersonal rules as in combat sports. Assuming that a control regulation from the teachers and an autonomous regulation from the learners jointly contribute to the solving of this concrete problem, this study tried (1) to identify and describe strategies used by the members (male and female) of a traditional private school to regulate the opposition on the tatami, and (2) to understand the rationality underlying these strategies. A qualitative analysis based on the use of several sources of data (interviews, observations, various documents) and of an original model revealed that what gender considered, the weakest practitioners were driven by a security stake. This common stake was coupled for men with a symbolic stake of preservation of their male sexual status, driving them to adopt tacit avoiding strategies. On the contrary, women negotiated openly with their rough partners, putting their feminine condition forward. The pedagogical intervention should take the existence of such a sexed autonomous regulation into account. [less ▲]

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See detailEmpathie et Trouble Oppositionnel chez l'enfant de 8 à 12 ans
Dahmen, Caroline; Malpas, Anne; Etienne, Anne-Marie ULg et al

in Revue Francophone de Clinique Comportementale et Cognitive (2004), IX(1), 3-11

A literature review underlines strong links between facial expression recognition difficulty, lack of empathy and behaviour disorder. The main goal of this study was to assess if, as it is suggested in ... [more ▼]

A literature review underlines strong links between facial expression recognition difficulty, lack of empathy and behaviour disorder. The main goal of this study was to assess if, as it is suggested in the literature, oppositional children presented an empathy deficit that can make them more aggressive. Forty children between 8 and 10 years old (15 control children and 15 oppositional children) were subjected to the “Empathy Response Task” from Ricard et Kamberk-Kilicci (1995). As expected, results show that oppositional children are significantly less empathic that control children. Anger is often assigned to protagonists even when it isn’t present. This can be interpreted by the “hostile attribution distortion” according to wich the children with behaviour disorders tend to allocate hostile intentions to others (Milich & Dodge, 1984). Working on empathy must be integrated in behaviour disorder children therapy. [less ▲]

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See detailJacques Ochs et l’Action wallonne (1933-1940)
Droixhe, Daniel ULg

in Jacques Ochs (1883-1971) (2004)

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See detailLe cas clinique du mois: Clarte pulmonaire unilaterale.
Quaedvlieg, Valérie ULg; Duysinx, Bernard ULg; Ghaye, Benoît ULg et al

in Revue Médicale de Liège (2004), 59(12), 691-4

MacLeod syndrome is a rare cause of localized hypertransradiancy of the lung. This syndrome is defined by radiological features: localized hypertransradiancy due to oligemia and presence of air-trapping ... [more ▼]

MacLeod syndrome is a rare cause of localized hypertransradiancy of the lung. This syndrome is defined by radiological features: localized hypertransradiancy due to oligemia and presence of air-trapping on expiratory chest radiography. Involvement of one entire lung is called "unilateral hyperlucent lung". Whereas the etiology is different, the physiopathology is probably identical to that of the panacinar emphysema of chronic obstructive pulmonary disease. The syndrome is believed to be related to acute bronchiolitis during infancy. Clinical manifestations and prognosis depend mainly on the presence of other lesions due to the same infectious agent like bronchiectasis. Pulmonary function tests, chest CT-scan, ventilation and perfusion scintigraphy and, if necessary, bronchoscopy help the differential diagnosis and detect associated bronchiectasis. [less ▲]

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See detailObserver pour favoriser l’apprentissage et l’éducation
Piéron, Maurice ULg; Cloes, Marc ULg

Part of book (2004)

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See detailMotiver pour éduquer, un éclairage qualitatif
Cloes, Marc ULg; Ledent, Maryse ULg; Piéron, Maurice ULg

in Carlier, Ghislain (Ed.) Si l’on parlait du plaisir d’enseigner l’éducation physique (2004)

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See detailSegregation of the bulk blend fertilizers
Miserque, Olivier; Pirard, Eric ULg

in Chemometrics and Intelligent Laboratory Systems (2004), 74(1), 215-224

Bulk blend fertilizers are a mixture of different kinds of fertilizers in order to obtain a predicted N-P-K chemical composition. Although this production method has some advantages, segregation appears ... [more ▼]

Bulk blend fertilizers are a mixture of different kinds of fertilizers in order to obtain a predicted N-P-K chemical composition. Although this production method has some advantages, segregation appears at different stages, from the production to the final spreading on the field. An experiment has been implemented to predict and quantify the influence of some physical properties on the occurrence of segregation. The principle was to blend two fertilizers having identical physical properties except for one, such as size, shape or density and to measure the segregation of the blend following various operations, such as filling or emptying a container. Results show that the spread of the fragment size distribution has a big influence on the segregation of the generated heap. In order to reduce this phenomenon, the granulometric spread index (GSI) [(d(84)-d(16))/2d(50)] must be smaller than 10. Other properties don't seem to have an influence. The granulometric segregation can lead to a chemical heterogeneity. The absolute sum of the difference between d(16) and d(84) must be limited around 0.5 mm. Above this value, the chemical segregation begins to be excessive. It seems also that if there is a limited difference in size for the components, the chemical segregation is amplified if the density of the fertilizer with the biggest particles is lower. It is not the case for the difference in shape. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailA generic approach for image classification based on decision tree ensembles and local sub-windows
Marée, Raphaël ULg; Geurts, Pierre ULg; Piater, Justus ULg et al

in Proceedings of the 6th Asian Conference on Computer Vision (2004)

A novel and generic approach for image classification is presented. The method operates directly on pixel values and does not require feature extraction. It combines a simple local sub-window extraction ... [more ▼]

A novel and generic approach for image classification is presented. The method operates directly on pixel values and does not require feature extraction. It combines a simple local sub-window extraction technique with induction of ensembles of extremely randomized decision trees. We report results on four well known and publicly available datasets corresponding to representative applications of image classification problems: handwritten digits (MNIST), faces (ORL), 3D objects (COIL-100), and textures (OUTEX). A comparison with studies from the computer vision literature shows that our method is competitive with the state of the art, an interesting result considering its generality and conceptual simplicity. Further experiments are carried out on the COIL-100 dataset to evaluate the robustness of the learned models to rotation, scaling, or occlusion of test images. These preliminary results are very encouraging [less ▲]

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See detailMineral mapping in salt lakes from Sud Lipez (Bolivia) using Aster images
Caceres, Fernando; Ali-Ammar, Hamid; Pirard, Eric ULg

in Geological Remote Sensing Group Newsletter (2004), (38), 15-19

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See detailImage Analysis of Iron Oxides under the Optical Microscope.
Pirard, Eric ULg; Lebichot, Sophie

in Tassinari, L. M.; Pecchio, M.; Andrade, F. R. (Eds.) et al Applied Mineralogy: Developments in Science and Technology (2004)

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See detailDirect estimation of sieve size distributions from 2-D image analysis of sand particles
Pirard, Eric ULg; Vergara, Nicolas; Chapeau, Vincent

in Proceedings PARTEC 2004 (2004)

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See detailTélédétection et télégestion des informations géologiques : de nouvelles technologies au service du développement.
Pirard, Eric ULg; Caceres, Fernando

in Bulletin des Séances de l’Académie Royale des Sciences d’Outre-Mer = Mededelingen der Zittingen van de Koninklijke Academie voor Overzeese Wetenschappen (2004), 50(3), 321-348

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See detailContribution to the study of the relations between fish of the family of Carapidae and their holothurian hosts
Parmentier, Eric ULg

in SPC Bêche de mer, Information Bulletin (2004), 19

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See detailParasites and biotic diseases in field and cultivated sea cucumbers
Eeckhaut, Igor; Parmentier, Eric ULg; Becker, P. et al

in Lovatelli, A.; Conand, C.; Purcell, S. (Eds.) et al Advances in sea cucumber aquaculture and management (2004)

Amongst echinoderms, the Holothuroidea represents the class that is the most infested by parasites. Parasites of holothuroids are Bacteria, Protozoa and Metazoa. There are about 150 species of metazoans ... [more ▼]

Amongst echinoderms, the Holothuroidea represents the class that is the most infested by parasites. Parasites of holothuroids are Bacteria, Protozoa and Metazoa. There are about 150 species of metazoans which parasite holothuroids. Most of them are turbellarians, gastropods, copepods, crabs or fishes. The main body compartments suffering of the infestations are the digestive system and the coelom. The diseases induced by metazoan parasites are mostly structural: they create galls at the surface of the epidermis, pierce the respiratory tree or dig into the body wall down to the coelom. Most metazoans that live in the digestive system do not induce obvious diseases and their relationship with their hosts is probably close to commensalism. Most Protozoa that parasite holothuroids are sporozoans. They occur mainly in the coelom and/or the haemal system, one species having been reported infesting the gonads. Even in heavily infested hosts, the signs of disease induced by sporozoans are low: at most, host haemal lacuna is occluded by trophozoites or cysts are formed into the coelomic epithelium. The most pathogen agents reported from cultured sea cucumbers are Bacteria. Cultivated holothuroids may suffer from a bacterial disease, called skin ulceration disease, that affects their body wall. In particular, juvenile Holothuria scabra reared in the Aqua-Lab hatchery of Toliara, Madagascar, suffered from such a disease that caused death within three days. The first sign of the infection is a white spot that appears on the integument of individuals, close to the cloacal aperture. The spot extends quickly onto the whole integument leading to the death of individuals. The lesions consist in a zone where the epidermis is totally destroyed and where collagen fibres and ossicles are exposed to the external medium. This zone is surrounded by a border line where degrading epidermis is mixed with connective tissue. Lesions include three bacterial morphotypes: rod-shaped bacteria, rough ovoid bacteria, and smooth ovoid bacteria. Three species of bacteria have also been put in evidence in the white spot lesions thanks to biomolecular analyses (DGGE and sequencing): Vibrio sp., Bacteroides sp., and an a-Proteobacterium. [less ▲]

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See detailInternal energy build-up in matrix-assisted laser desorption/ionization
Gabelica, Valérie ULg; Schulz, Eric; Karas, Michael

in Journal of Mass Spectrometry [=JMS] (2004), 39(6), 579-593

This paper reports detailed studies on the internal energy of ions formed in matrix-assisted laser desorption/ionization (MALDI) using delayed extraction MALDI-time-of-flight (TOF) and atmospheric ... [more ▼]

This paper reports detailed studies on the internal energy of ions formed in matrix-assisted laser desorption/ionization (MALDI) using delayed extraction MALDI-time-of-flight (TOF) and atmospheric pressure (AP) MALDI mass spectrometric (MS) methods. We use benzylpyridinium cations as internal energy probes. Our study reveals three distinct contributions to internal energy build-up in vacuum-MALDI (classical MALDI-TOF), each having different effects on ion fragmentation. Some fragments are formed before ion extraction (i.e. no more than 100 ns after the laser impact), and they are therefore well resolved and recorded as sharp signals in the MALDI-TOFMS scan. This prompt fragmentation can have two origins: (i) in-plume thermal activation, presumably always present, and (ii) in-plume chemical activation, in the course of reactions with hydrogen radicals. In addition to early internal energy build-up associated with these well-resolved promptly formed fragments, a broad peak slightly offset to higher masses could be detected corresponding to fragments formed after the extraction has started. This second signal corresponds to a third source of internal energy in MALDI ions, (iii) the extraction-induced collisional activation of the ions with the neutral components of the plume. These three contributions are difficult to quantify in vacuum-MALDI, because of the combined influence of several parameters (nature of the matrix, spot-to-spot variability, total laser exposure, delay time, acceleration voltage) on extraction-induced fragmentation. AP-MALDI, on the other hand, has two advantages for comparative studies of analyte fragmentation. First, extraction-induced fragmentation is absent, and only the contributions of early plume activation remain. Second, the reproducibility is far better than in vacuum-MALDI. AP-MALDI is therefore expected to shed new light on the early steps of the MALDI process. Copyright (C) 2004 John Wiley Sons, Ltd. [less ▲]

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See detailA Psammosteid Heterostracan (Vertebrata: Pteraspidomorphi) from the Emsian (Lower Devonian) of the Grand Duchy of Luxembourg
Delsate, D.; Blieck, A.; Steemans, Philippe ULg

in Geologica Belgica (2004), 7(1-2), 21-26

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