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See detailLa mannheimiose : d’une liaison (moléculaire) fatale à une des principales maladies d’élevage des ruminants
Fett, Thomas ULg; Zecchinon, Laurent; Vanden Bergh, Philippe et al

in Annales de Médecine Vétérinaire (2009), 153(1), 31-53

Les pneumonies bactériennes constituent un problème majeur dans l'élevage et l'engraissement des bovins, avec des répercussions très élevées en termes de morbidité et de mortalité. Parmi les différentes ... [more ▼]

Les pneumonies bactériennes constituent un problème majeur dans l'élevage et l'engraissement des bovins, avec des répercussions très élevées en termes de morbidité et de mortalité. Parmi les différentes causes biologiques recensées, Mannheimia haemolytica tient le haut de l’affiche puisqu’elle est connue comme agent pathogène compliquant principal, voire systématique. Une de ses particularités est qu’elle ne déclenche de pneumonie broncho-alvéolaire fibrino-hémorragique que chez les ruminants. Les lésions observées résultent d’une nécrose en masse des neutrophiles et macrophages et du relarguage de leurs différents constituants. Au niveau moléculaire, cette spécificité trouve son origine dans l’intimité de la liaison entre la leucotoxine, le facteur de virulence majeur de la bactérie, et la sous-unité CD18 des récepteurs de surface leucocytaires bêta2-intégrines. La revue décrit cette liaison et ses conséquences aux niveaux macroscopique et microscopique, avant de faire le point sur les dernières avancées de la recherche et d’ébaucher quelques perspectives thérapeutiques. [less ▲]

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See detailTwo-year clinical, angiographic, and intravascular ultrasound follow-up of the XIENCE V everolimus-eluting stent in the treatment of patients with de novo native coronary artery lesions: the SPIRIT II trial.
Claessen, Bimmer E.; Beijk, Marcel A.; Legrand, Victor ULg et al

in Circulation. Cardiovascular interventions (2009), 2(4), 339-47

BACKGROUND: This article reports the 2-year clinical, angiographic, and intravascular ultrasound outcomes of the everolimus-eluting stent (EES) compared with the paclitaxel-eluting stent (PES) in the ... [more ▼]

BACKGROUND: This article reports the 2-year clinical, angiographic, and intravascular ultrasound outcomes of the everolimus-eluting stent (EES) compared with the paclitaxel-eluting stent (PES) in the randomized SPIRIT II trial. METHODS AND RESULTS: This was a prospective, single-blind clinical trial in which a total of 300 patients with de novo native coronary artery lesions were randomized to either EES or PES in a 3:1 fashion. Clinical follow-up was planned at 2 years in all patients. A subset of 152 patients underwent serial angiographic and intravascular ultrasound analyses at 6 months and 2 years. After 2 years, target lesion failure (cardiac death, myocardial infarction, and ischemia-driven target lesion revascularization) rates were 6.6% and 11% in EES and PES, respectively (P=0.31). At 6 months, a significant reduction in angiographic in-stent late loss and percentage volume obstruction measured by intravascular ultrasound was observed in the EES group. However, at 2-year follow-up, a late increased intimal hyperplasia growth after implantation of an EES was observed. There were no significant differences between EES and PES for in-stent late loss (EES, 0.33+/-0.37 mm versus PES, 0.34+/-0.34 mm; P=0.84) and percentage volume obstruction (EES, 5.18+/-6.22% versus PES, 5.80+/-6.31%; P=0.65) at 2 years. The incidence of stent thrombosis was low and comparable in both groups (EES, 0.9%; PES, 1.4%). CONCLUSIONS: Although the previously reported angiographic and clinical superiority of the EES has vanished over time, this report confirms and extends the previously demonstrated noninferiority in terms of in-stent late loss of the EES when compared with the PES up to 2-year follow-up. There were no significant differences between EES and PES in clinical, angiographic and intravascular ultrasound outcomes at 2 years. [less ▲]

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See detailLes quartiers durables : processus de production et reproductibilité
Marique, Anne-Françoise ULg

Master's dissertation (2009)

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See detailExpressing female fertility in the Walloon region of Belgium: how to do?
Vanderick, Sylvie ULg; Bastin, Catherine ULg; Gengler, Nicolas ULg

in Interbull Bulletin (2009), 40

Since September 2007, the Walloon Region of Belgium has used a genetic evaluation system for pregnancy rate in Holsteins and has participated in 3 of the 5 MACE trait INTERBULL runs for female fertility ... [more ▼]

Since September 2007, the Walloon Region of Belgium has used a genetic evaluation system for pregnancy rate in Holsteins and has participated in 3 of the 5 MACE trait INTERBULL runs for female fertility. In order to define general way of female fertility expression, a principal component analysis was carried out on six published foreign female fertility indexes. Results of were used to compute a direct female fertility index with the INTERBULL international female fertility proofs available on the Walloon scale. An indirect female fertility index was also developed in order to increase reliability of young bulls. Approximate procedure based on selection index was used to combine both indexes in an overall index called combined female fertility index. This index was highly correlated with the direct female fertility index (.96) and the first principal component (.85), therefore it was considered as good expression of female fertility. Moreover, this allowed recovering 4,019 INTERBULL bulls with a publishable female fertility index. [less ▲]

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See detailModave/Modave : fouilles au niveau de l'interruption du rempart à Pont-de-Bonne
Delye, Emmanuel ULg

in Chronique de l'Archéologie Wallonne (2009), 16

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See detailLe SoTL en pratique : comment le développer ?
Georges, François ULg; Poumay, Marianne ULg

in Collected Essays on Learning and Teaching (2009), II

Le courant du Scholarship of Teaching and Learning (SoTL, Boyer 1990, Kreber 2002) influence nos formations continuées pour formateurs d’adultes et pour enseignants du primaire, du secondaire et du ... [more ▼]

Le courant du Scholarship of Teaching and Learning (SoTL, Boyer 1990, Kreber 2002) influence nos formations continuées pour formateurs d’adultes et pour enseignants du primaire, du secondaire et du supérieur : nous les organisons dorénavant de façon à susciter un réel développement professionnel par la pratique réflexive, la recherche en classe et une systématique communication sur les avancées des enseignants. Pour outiller ces formations, autant la littérature est abondante et les intentions largement partagées, autant les exemples concrets d’activités ne font pas légion. Dans cet article, nous proposons de relater une expérience réflexive menée par des enseignants du secondaire à partir de traces d’apprentissage laissées par leurs élèves dans une plateforme d’enseignement en ligne destinée à soutenir le développement des compétences « lire » et « écrire » en français. [less ▲]

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See detailExperimental investigation of flow and deposit patterns in rectangular shallow reservoirs: preliminary analysis
Dufresne, Matthieu ULg; Dewals, Benjamin ULg; Erpicum, Sébastien ULg et al

in Proceedings International Workshop on Environmental Hydraulics: Theoretical, Experimental and Computational Solutions (2009)

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See detailThe Influence of Phylogenic Origin on the Occurrence of Brachycephalic Airway Obstruction Syndrome in a Large Retrospective Study
Njikam Nsangou, Ibrahim ULg; Huault, Maxime; Pirson, Vincent et al

in International journal of applied research in veterinary medicine (2009), 7(3), 138-143

Strategies to identify genetic polymorphisms responsible for inherited disorders in purebred dog population are often based on experimental studies whereas hospitals case reports provide widely and easily ... [more ▼]

Strategies to identify genetic polymorphisms responsible for inherited disorders in purebred dog population are often based on experimental studies whereas hospitals case reports provide widely and easily affordable information of clinical significance. When this clinical information is enriched with knowledge on the phylogenetic origins, breed histories of the dog and adjusted for known biases, they may lead the way to more in depth genetic research. We illustrated here with a very complex disease, the brachycephalic airway obstruction syndrome (BAOS). No cases were reported in the boxer breed while almost half of the dogs from the other brachycephalic breeds of the same phylogenetic cluster were BAOS, making these breeds good candidates for further genetic studies. Critical issues to improve utility of clinical data for genetic studies are discussed along with methods to handle biases inherent to such type of studies. [less ▲]

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See detailL’écartement de la loi étrangère au profit du droit belge en matière d’adoption
Pfeiff, Silvia ULg

in Revue du Droit des Etrangers [= RDE] (2009)

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See detailCharacterization of Oligomeric Species on the Aggregation Pathway of Human Lysozyme
Frare, Erica; Mossuto, Maria F.; Polverino de Laureto, Patrizia et al

in Journal of Molecular Biology (2009), 387

has been analyzed by characterizing a series of distinct species formed on the aggregation pathway, specifically the amyloidogenic monomeric precursor protein, the oligomeric soluble prefibrillar ... [more ▼]

has been analyzed by characterizing a series of distinct species formed on the aggregation pathway, specifically the amyloidogenic monomeric precursor protein, the oligomeric soluble prefibrillar aggregates, and the mature fibrils. Particular attention has been focused on the analysis of the structural properties of the oligomeric species, since recent studies have shown that the oligomers formed by lysozyme prior to the appearance of mature amyloid fibrils are toxic to cells. Here, soluble oligomers of human lysozyme have been analyzed by a range of techniques including binding to fluorescent probes such as thioflavin T and 1-anilino-naphthalene-8-sulfonate, Fourier transforminfrared spectroscopy, and controlled proteolysis. Oligomers were isolated after 5 days of incubation of the protein and appear as spherical particles with a diameter of 8–17 nm when observed by transmission electron microscopy. Unlike the monomeric protein, oligomers have solventexposed hydrophobic patches able to bind the fluorescent probe 1-anilinonaphthalene- 8-sulfonate. Fourier transforminfrared spectroscopy spectra of oligomers are indicative of misfolded species when compared to monomeric lysozyme, with a prevalence of random structure but with significant elements of the β-sheet structure that is characteristic of the mature fibrils. Moreover, the oligomeric lysozyme aggregates were found to be more susceptible to proteolysis with pepsin than both the monomeric protein and the mature fibrils, indicating further their less organized structure. In summary, this study shows that the soluble lysozyme oligomers are locally unfolded species that are present at low concentration during the initial phases of aggregation. The nonnative conformational features of the lysozyme molecules of which they are composed are likely to be the factors that confer on them the ability to interact inappropriately with a variety of cellular components including membranes. [less ▲]

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See detailIsolation, characterization and PCR multiplexing of polymorphic microsatellite markers in the edible dormouse, Glis glis
Huerner, H.; Martin, Jacques ULg; Ribas, A. et al

in Molecular Ecology Resources (2009), 9(3), 885-887

We isolated and characterized 10 dinucleotide microsatellite loci in the edible dormouse, Glis glis (Linnaeus). Four multiplex panels were developed. Loci were amplified in samples from two geographically ... [more ▼]

We isolated and characterized 10 dinucleotide microsatellite loci in the edible dormouse, Glis glis (Linnaeus). Four multiplex panels were developed. Loci were amplified in samples from two geographically distant populations (Torgny in Belgium and Montseny in Spain). All loci were polymorphic in Spain but four were monomorphic in Belgium. Individuals from Belgium and Spain exhibited an average allelic diversity of 1.9 and 3.3 and an observed heterozygosity ranging from 0.08 to 0.47 and from 0.04 to 0.72, respectively. [less ▲]

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See detailOptimal rail-road container terminal locations on the European network
Limbourg, Sabine ULg; Jourquin, Bart

in Transportation Research. Part E: Logistics and Transportation Review (2009), 45(4), 551-563

The European transport policy has focused on sustainable transport solutions, among which intermodal transport is a key player. However, its efficiency is strongly dependent on the location of the ... [more ▼]

The European transport policy has focused on sustainable transport solutions, among which intermodal transport is a key player. However, its efficiency is strongly dependent on the location of the container terminals. In this paper, a set of estimated potential locations is used as input for an iterative procedure based on the p-hub median problem that takes the variation in trans-shipment costs according to the number of trans-shipped containers into account. The final results are the optimal locations for European transfer terminals embedded in a hub-and-spoke network. [less ▲]

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See detailFrom subspace learning to distance learning: a geometrical optimization approach
Meyer, Gilles ULg; Journée, Michel; Bonnabel, Silvère et al

in Proceedings of the 2009 IEEE Workshop on Statistical Signal Processing (SSP2009) (2009)

In this paper, we adopt a differential-geometry viewpoint to tackle the problem of learning a distance online. As this prob- lem can be cast into the estimation of a fixed-rank positive semidefinite (PSD ... [more ▼]

In this paper, we adopt a differential-geometry viewpoint to tackle the problem of learning a distance online. As this prob- lem can be cast into the estimation of a fixed-rank positive semidefinite (PSD) matrix, we develop algorithms that ex- ploits the rich geometry structure of the set of fixed-rank PSD matrices. We propose a method which separately updates the subspace of the matrix and its projection onto that subspace. A proper weighting of the two iterations enables to continu- ously interpolate between the problem of learning a subspace and learning a distance when the subspace is fixed. [less ▲]

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See detailAmazonía: civilisations et barbaries
Vanden Berghe, Kristine ULg; Berlage, Pauline

Book published by Les éditions de l'Université de Liège (2009)

Cet ouvrage est la première publication de synthèse de l’accord tripartite signé en novembre 2006 entre l’Université de Liège, la Universidad Central del Ecuador de Quito et la Universidade Federal do ... [more ▼]

Cet ouvrage est la première publication de synthèse de l’accord tripartite signé en novembre 2006 entre l’Université de Liège, la Universidad Central del Ecuador de Quito et la Universidade Federal do Amazonas de Manaus. Puisque cet accord concerne quatre domaines de recherche -le transport fluvial, la biotechnologie, l’anthropologie et la littérature-, ce livre offre des perspectives variées quant à la région amazonienne. Les articles inclus explorent les énormes richesses de cette région, soulignent les défis auxquels elle devra faire face et questionnent les imaginaires qu’elle suscite depuis l’Europe ou l’Amérique latine elle-même. L’ouvrage offre également des visions complémentaires dans la mesure où il noue un dialogue entre des chercheurs travaillant dans des contextes épistémologiques et géographiques très éloignés les uns des autres, une perspective interculturelle que nous désirons cultiver tout au long de cet accord tripartite et qui ne manquera pas d’interpeller le lecteur. [less ▲]

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See detailDialogues interculturels entre Liège, Manaus et Quito
Vanden Berghe, Kristine ULg

in Vanden Berghe, Kristine (Ed.) Amazonía: civilisations et barbaries (2009)

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See detailAdaptation and testing of data reconciliation software for CAPE-OPEN compliance
Radermecker, Eric; Dumont, Marie-Noëlle ULg; Heyen, Georges ULg

in Computer Aided Chemical Engineering (2009), 26

The experience gained in the development of a CAPE-OPEN 1.0 thermo socket for the BELSIM-VALI software is presented. A material object has been developed and interfaced with the modelling code. The user ... [more ▼]

The experience gained in the development of a CAPE-OPEN 1.0 thermo socket for the BELSIM-VALI software is presented. A material object has been developed and interfaced with the modelling code. The user interface has been adapted. Several case studies were analysed, with performance comparison between the native thermodynamic model, and properties obtained from several CAPE-OPEN thermo plugs. [less ▲]

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See detailSujets « métaboliquement sains », bien qu’obèses 2ème partie : pronostic et prise en charge
Esser, Nathalie ULg; PAQUOT, Nicolas ULg; SCHEEN, André ULg

in Obésité (2009), 4

Around 30 to 50 % of obese subjects are « metabolically normal » (MHO) whereas numerous non obese subjects are « metabolically abnormal ». The distribution and the function of adipose depots seem to play ... [more ▼]

Around 30 to 50 % of obese subjects are « metabolically normal » (MHO) whereas numerous non obese subjects are « metabolically abnormal ». The distribution and the function of adipose depots seem to play a crucial role to explain this apparent discrepancy. In a first paper, we described the clinical and biological characteristics of these MHO individuals, analyzed the underlying pathophysiological mechanisms, and reported the prevalence of this syndrome in the adult population. This second paper aims at assessing the prognosis, especially regarding the risk of diabetes and cardiovascular disease, and at discussing the advantages and disadvantages of a classical therapeutic strategy of obesity among MHO individuals. [less ▲]

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