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See detailConfrontation entre le Szondi et le Rorschach
Stassart, Martine ULg

Conference (2002, January 30)

The author comments the conclusions of the research of Pr Jean Mélon about the correlations between Szondi- and Rorschachtests of 562 subjects (Doctoral These in Psychology, "Figures du moi. Szondi ... [more ▼]

The author comments the conclusions of the research of Pr Jean Mélon about the correlations between Szondi- and Rorschachtests of 562 subjects (Doctoral These in Psychology, "Figures du moi. Szondi, Rorschach et Freud ", May 1976, University of Liege). [less ▲]

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See detailMatrix and serine protease expression during leukemic cell differentiation induced by aclacinomycin and all-trans-retinoic acid
Devy, L.; Hollender, P.; Munaut, Carine ULg et al

in Biochemical Pharmacology (2002), 63(2), 179-189

In myeloid leukemia, immature leukemic cells are able to egress into peripheral blood to infiltrate extra-medullary organs. We therefore analyzed the migrating and invasive potential of human HL-60 and ... [more ▼]

In myeloid leukemia, immature leukemic cells are able to egress into peripheral blood to infiltrate extra-medullary organs. We therefore analyzed the migrating and invasive potential of human HL-60 and NB4 cell lines, representative of acute myelogenous leukemia, their ability to express matrix metalloproteases (MMPs), tissue inhibitors of metalloproteases (TIMPs) and urokinase plasminogen activator (uPA) in response to differentiating agents. Granulocytic differentiation by all-trans-retinoic acid (ATRA) and aclacinomycin (ACLA) strongly increased HL-60 and NB4 cell migration and invasion. At mRNA and protein levels, these cell lines produced significant amounts of MMP-9 (HL-60 < NB4). Granulocytic differentiation by ACLA increased both pro and active forms of MMP-9 whereas ATRA decreased them and stimulated uPA mRNAs. TIMP-1, the physiological MMP inhibitor, increased during granulocytic differentiation whereas TIMP-2 did not significantly vary. Use of Batimastat and aprotinin suggests that ATRA was active by modulating the uPA system while ACLA interfered with MMP expression. In conclusion, our data demonstrate that HL-60 and NB4 cells express MMPs and uPA which are differentially regulated by the differentiating agents ATRA and ACLA and suggest the clinical usefulness of MMPs and serine protease inhibitors in the prophylaxis and treatment of the ATRA syndrome. (C) 2002 Elsevier Science Inc. All rights reserved. [less ▲]

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See detailEfficacy of the new long-acting formulation of lanreotide (lanreotide Autogel) in the management of acromegaly.
Caron, Ph; Beckers, Albert ULg; Cullen, C. R. et al

in Journal of Clinical Endocrinology and Metabolism (2002), 87(1), 99-104

Lanreotide Autogel is a new long-acting aqueous preparation of lanreotide for the treatment of acromegaly and is administered by deep sc injection from a small volume, prefilled syringe. The aim of this ... [more ▼]

Lanreotide Autogel is a new long-acting aqueous preparation of lanreotide for the treatment of acromegaly and is administered by deep sc injection from a small volume, prefilled syringe. The aim of this study was to evaluate the efficacy and safety of this new long-acting formulation in a large population of acromegalic patients previously responsive to lanreotide 30 mg, im (sustained release microparticle formulation). Lanreotide Autogel was administered by deep sc injection every 28 d to 107 patients (54 males and 53 females; mean age, 54 +/- 1.2 yr). All patients had been treated with lanreotide (30 mg) for at least 3 months before study entry and had a mean GH level less than 10 ng/ml after at least 4 subsequent im injections every 14 d (48%), 10 d (32%), or 7 d (20%). Treatment was switched from lanreotide 30 mg injected every 14, 10, or 7 d to 60, 90, or 120 mg lanreotide Autogel, respectively, every 28 d. After three fixed dose injections of lanreotide Autogel, mean lanreotide levels were similar to those obtained at steady state with lanreotide 30 mg. During lanreotide Autogel treatment, the control of acromegalic symptoms was comparable with that previously achieved during lanreotide 30 mg treatment. After 3 injections of lanreotide Autogel, mean GH (2.87 +/- 0.22 ng/ml) and IGF-I (317 +/- 15 ng/ml) values were comparable with those recorded at the end of lanreotide 30 mg treatment (GH, 2.82 +/- 0.19 ng/ml; IGF-I, 323 +/- 16 ng/ml). GH levels below 2.5 ng/ml and age-/sex-normalized IGF-I were achieved in 33% and 39% of patients during lanreotide 30 mg and lanreotide Autogel treatment, respectively. Diarrhea, abdominal pain, and nausea were reported by 38%, 22%, and 18% of patients during lanreotide 30 mg treatment and by 29%, 17%, and 9% of patients, respectively, during lanreotide Autogel treatment. In conclusion, this clinical study shows that lanreotide Autogel is at least as efficacious and well tolerated as lanreotide 30 mg. This new long-acting lanreotide formulation, lanreotide Autogel, which is administered from a small volume, prefilled syringe by deep sc injection, is therefore likely to improve the acceptability of medical treatment for patients requiring long-term somatostatin analog therapy. [less ▲]

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See detailLes couleurs : une caractéristique de la lumière
Brouwir, Christine ULg; Hindryckx, Marie-Noëlle ULg

Learning material (2002)

Document élaboré à l'usage des instituteurs du fondamental, désireux de faire des sciences en classe sur le thème des couleurs de la lumière : mise au point théorique

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See detailLes anomalies morphologiques et metaboliques liees aux traitements antiretroviraux
Debruyn, X.; Nkoghe, D.; Leonard, Philippe ULg et al

in Revue Médicale de Liège (2002), 57(1), 23-8

The long term use of antiretroviral therapy is associated with metabolic and morphological abnormalities named lipodystrophy. The understanding of its epidemiology is in progress. NRTIs and Pls are ... [more ▼]

The long term use of antiretroviral therapy is associated with metabolic and morphological abnormalities named lipodystrophy. The understanding of its epidemiology is in progress. NRTIs and Pls are involved in the origin of these abnormalities. So, NRTIs inhibit mitochondrial gamma polymerase and induce body fat distribution disorders. PIs interfere with lipid metabolism, leading to hyperlipidaemia and insulin resistance symptomatology. The diagnosis is made by clinical (far wasting or accumulation, or mixed syndrome) and biological signs (hyperlipidaemia, hyperglycaemia, hyperlactacidaemia). Radiological exams can quantify morphological abnormalities. The management consists in drug substitution, diet and exercise, and corrective drugs. Plastic surgery can be useful. [less ▲]

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See detailAnti-CD3/anti-epidermal growth factor receptor-bispecific antibody retargeting of lymphocytes against human neoplastic keratinocytes in an autologous organotypic culture model
Renard, I.; Mezzanzanica, Delia; Canevari, Silvana et al

in American Journal of Pathology (2002), 160(1), 113-122

Local cellular immune defects have been described in several tumors including human papillomavirus (HPV)-associated cervical cancer. This observation suggests the potential therapeutic benefit of immune ... [more ▼]

Local cellular immune defects have been described in several tumors including human papillomavirus (HPV)-associated cervical cancer. This observation suggests the potential therapeutic benefit of immune manipulations that restore cellular immunity. Here, we evaluated the ability of bispecific monoclonal antibodies (bimAbs) to redirect T cells against keratinocytes transformed in vitro by HPV in an autologous three-dimensional culture model (organotypic cultures). The epidermal growth factor receptor (EGFR) was chosen as target for an anti-CD3/anti-EGFR bimAb because it is overexpressed in many malignant epithelial lesions and only weakly expressed in the basal layers of normal squamous epithelium. Interestingly, in organotypic cultures, the pattern of expression of EGFR was similar to that observed in vivo. The ability of T cells retargeted by CD3/EGFR bimAb to lyse HPV-transformed cell lines was confirmed in monolayer cultures. In autologous organotypic cultures, an increase in apoptotic HPV(+) keratinocytes and a significant decrease in the thickness of HPV(+) organotypic cultures were observed when activated lymphocytes and bimAbs were added to the cultures, whereas organotypic cultures of normal keratinocytes were not significantly affected. These data were similar to those obtained in the allogeneic model. These results suggest the potential usefulness of CD3-EGFR bimAb-retargeted lymphocytes in immunotherapeutic protocols for malignant epithelial lesions. [less ▲]

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See detailEstablishment of a geographic data dictionnary : a case study of UrbIS 2 ©, the Brussels regional government GIS
Pantazis, Dimos; Cornélis, Bernard; Billen, Roland ULg et al

in Computers, Environment & Urban Systems (2002), 26(1), 3-17

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See detailLe cas clinique du mois. Membrane sous-valvulaire aortique
Radermecker, M.A.; Dresse, Denise ULg; Grenade, T. et al

in Revue Médicale de Liège (2002), 57(1), 7-9

A case of fixed subvalvular aortic stenosis is reported. This clinical observation is the occasion to review the pathophysiology of this lesion and the last developments in the surgical treatment.

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See detailConservation of the lesser horseshoe bat (Rhinolophus hipposideros Bechstein, 1800) (Mammalia : Chiroptera) in Belgium. A case study of feeding habitat requirements
Motte, G.; Libois, Roland ULg

in Belgian Journal of Zoology (2002), 132(1), 49-54

The aim of this study was to determine the habitat use of the last important Belgian colony of Rhinolophus hipposideros, Bechstein, 1800, one of the most endangered bat species in Europe. During 71 ... [more ▼]

The aim of this study was to determine the habitat use of the last important Belgian colony of Rhinolophus hipposideros, Bechstein, 1800, one of the most endangered bat species in Europe. During 71 evenings from April to August 1998, ultrasound detection was performed and, in late August, a female horseshoe bat was caught and fitted with a radio transmitter. The results showed that hedgerows and woodlands with bushes and coppice are key foraging habitats. They also highlight the importance of the presence of a network of wooded elements connecting the maternity roost with the foraging areas. To assure long-term protection of this colony, strong habitat conservation measures should be taken in a radius of up to 1-2 km around the roost. [less ▲]

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See detailEffect of endogenous serotonin on the binding of the 5-HT1A PET ligand 18 F in the rat hippocampus: kinetic b measurements combined with microdialysis
Zimmer, Luc; Mauger, Gweltas; Le Bars, Didier et al

in Journal of Neurochemistry (2002), 80(2), 278-286

By using a combination of an original beta(+)-sensitive intracerebral probe and microdialysis, the effect of increased endogenous serotonin on specific binding of F-18-MPPF [4-(2'-methoxy-phenyl)-1-[2'-[N ... [more ▼]

By using a combination of an original beta(+)-sensitive intracerebral probe and microdialysis, the effect of increased endogenous serotonin on specific binding of F-18-MPPF [4-(2'-methoxy-phenyl)-1-[2'-[N-(2"-pyridinyl)-p-fluorobenzamido]ethyl]piperazine] to the serotonin-1A (5-HT1A) receptors was investigated in the hippocampus of the anaesthetized rat. Our beta-sensitive probe prototype was sensitive enough to obtain Specific F-18-MPPF time-activity curves in the rodent (hippocampus/cerebellum ratio approximate to 2). The serotonin neuronal release was pharmacologically enhanced using fenfluramine at three different doses (1, 2 and 10 mg/kg intravenous) multiplying by 2-15 the extracellular serotonin in the hippocampus. These extracellular variations of extracellular serotonin resulted in dose-ranging decreases in F-18-MPPF-specific binding in the same rat. Our results showed for the first time that F-18-MPPF binding could be modulated by modifications of extracellular serotonin in the rat hippocampus. These results were confirmed by the enhancement of extracellular radioactivity collected in dialysates after the displacement of F-18-MPPF by fenfluramine. After modelization, F-18-MPPF binding could constitute an interesting radiotracer for positron emission tomography in evaluating the serotonin endogenous levels in limbic areas of the human brain. [less ▲]

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See detailLes kystes bronchogeniques: observation clinique et revue de la litterature
RADERMECKER, Marc ULg; Moscato, A.; Delbecque, Katty ULg et al

in Revue Médicale de Liège (2002), 57(1), 45-8

Pulmonary bronchogenic cysts are benign lesions that can be suspected from clinical background and imaging. We present the case of a huge subcarinal bronchogenic cyst and review the embryology ... [more ▼]

Pulmonary bronchogenic cysts are benign lesions that can be suspected from clinical background and imaging. We present the case of a huge subcarinal bronchogenic cyst and review the embryology, physiopathology, surgical indications and techniques of this congenital lesion. [less ▲]

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See detailXlim3D: Un logiciel de traitement d'image
Van Droogenbroeck, Marc ULg

Report (2002)

Mode d'emploi et descriptif du logiciel Xlim3D

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See detailLe caricaturiste offre sinon la réalité, du moins l’illusion d’une liberté
Durand, Pascal ULg; Vaute, Paul

Article for general public (2002)

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See detailMorsure de chien chez un patient splénectomisé
Delanaye, Pierre ULg; Dubois, Colette ULg; Mendes, Pedro et al

in Revue Médicale de Liège (2002), 57(1), 40-4

We present a case of Capnocytophaga canimorsus fulminant infection linked to a dog bite in a splenectomized patient. Capnocytophaga canimorsus is a gram-negative rod that typically causes septicaemia with ... [more ▼]

We present a case of Capnocytophaga canimorsus fulminant infection linked to a dog bite in a splenectomized patient. Capnocytophaga canimorsus is a gram-negative rod that typically causes septicaemia with disseminated intravascular coagulation in both immunocompromised and immunocompetent hosts. It is associated with high mortality. We also reviewed the literature and provide some recommendations on the management of bite wound as well as on both prevention and treatment of infection in asplenic state. [less ▲]

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See detailEtude clinique du mois. Effets du valsartan dans l'insuffisance cardiaque chronique: l'etude Val-HeFT
Pierard, Luc ULg

in Revue Médicale de Liège (2002), 57(1), 57-9

Current guidelines recommend drugs which reduce neurohormonal activation as standard therapy for heart failure: angiotensin converting-enzyme (ACE) inhibitors, beta-blockers and spironolactone. The ... [more ▼]

Current guidelines recommend drugs which reduce neurohormonal activation as standard therapy for heart failure: angiotensin converting-enzyme (ACE) inhibitors, beta-blockers and spironolactone. The Valsartan Heart Failure Trial (Val-HeFT) tested the efficacy of the angiotensin-receptor blocker valsartan in addition to prescribed therapy. A total of 5010 patients with heart failure of NYHA class II, III or IV were randomly assigned to receive 160 mg of valsartan or placebo twice daily. Further angiotensin antagonism by valsartan did not improve survival but was beneficial in terms of morbidity and mortality, because of reduced rate of hospitalization, significant improvements in NYHA class, ejection fraction, signs and symptoms of heart failure, and quality of life. Valsartan had highly favourable effects in patients not receiving ACE inhibitors but an adverse effect in patients receiving both ACE inhibitors and beta-blockers. The effects of adding valsartan are depending on the importance of previous neurohormonal inhibition. [less ▲]

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See detailPharma-clinics le medicament du mois. Le rabeprazole (Pariet)
Louis, Edouard ULg

in Revue Médicale de Liège (2002), 57(1), 53-6

Proton pomp inhibitors (PPI) have revolutionized the treatment of gastro-oesophageal reflux disease and gastro-duodenal ulcers. Rabeprazole (Pariet) is the last PPI arrived on the Belgian market ... [more ▼]

Proton pomp inhibitors (PPI) have revolutionized the treatment of gastro-oesophageal reflux disease and gastro-duodenal ulcers. Rabeprazole (Pariet) is the last PPI arrived on the Belgian market. Controlled studies have shown an efficacy similar to emeprazole in the treatment of oeso-gastro-duodenal acid diseases. Rabeprazole has a favourable profile with rapid action and good safety. [less ▲]

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See detailSport-études : Comparaison des caractéristiques motivationnelles et des relations sociales des élèves sportifs et de leurs condisciples
Cloes, Marc ULg; Schelings, Virginie; Ledent, Maryse ULg et al

in e Journal de la Recherche sur l'Intervention en Education Physique et Sport (2002), 1

Le sport-études a été créé afin de permettre aux jeunes ayant de bonnes dispositions sportives de les développer dans le cadre d’un programme intégré à leur formation scolaire. Si les modalités pratiques ... [more ▼]

Le sport-études a été créé afin de permettre aux jeunes ayant de bonnes dispositions sportives de les développer dans le cadre d’un programme intégré à leur formation scolaire. Si les modalités pratiques diffèrent largement d’une structure à l’autre selon la législation en vigueur, les sportifs sont inévitablement confrontés à des problèmes communs. Bizarrement, peu d’études semblent s’y être intéressées. Par ailleurs, les élèves qui partagent la formation scolaire des sportifs constituent un groupe auquel il n’est jamais fait référence. [less ▲]

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See detailLes jeunes peuplements mélangés de hêtres et de bouleaux : étude bibliographique sur la forme des hêtres (cahier technique n°18)
Kiss, S.; Claessens, Hugues ULg

in Forêt Wallonne (2002), (55-56), 1-14

Avec cet article sur la mise en place de l’architecture du hêtre, de la plantule à l’arbre adulte, et sur les causes de sa malformation, nous entamons un cycle de deux cahiers techniques dédiés à la ... [more ▼]

Avec cet article sur la mise en place de l’architecture du hêtre, de la plantule à l’arbre adulte, et sur les causes de sa malformation, nous entamons un cycle de deux cahiers techniques dédiés à la sylviculture du hêtre en mélange avec le bouleau. Les premières parties abordent la définition d’une architecture d’arbre idéal et le rôle de la concurrence sur la forme des hêtres. Ces notions permettront, dans les parties ultérieures, de mieux désigner les individus destinés à devenir des arbres « objectif » et à comprendre le rôle des essences compagnes dans les plantations mélangées. Le bouleau servira d’essence de bourrage pour l’élaboration d’une sylviculture d’arbres adaptée aux mélanges. [less ▲]

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See detailLa restauration du maillage écologique: une nécessité pour assurer la conservation de l'herpétofaune en Wallonie
Graitson, Eric ULg; Jacob, Jean-Paul

in Natura Mosana (2002), 54(4), 21-36

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See detailA scheduler for relative delay service differentiation
Jennes, Geoffroy ULg; Leduc, Guy ULg; Tufail, Mudassir

in Annales des Télécommunications = Annals of Telecommunications (2002), 57(1-2, JAN-FEB), 83-104

We propose a new delay-based scheduler called as RD-VC (Relative Delay VirtualClock). Since it performs a delay-based service differentiation among flow aggregates, the quality at microflow level is the ... [more ▼]

We propose a new delay-based scheduler called as RD-VC (Relative Delay VirtualClock). Since it performs a delay-based service differentiation among flow aggregates, the quality at microflow level is the same as that at aggregate level. This is not easily achievable when the service differentiation is bandwidth-based or loss-based. Unlike the EDF (Earliest Deadline First) scheduler [1], our proposed scheduler self-regulates and adapts the delays according to load changes. This characteristic permits its to implement it in an AF-like PHB providing the relative quantification service in a DiffServ network. Finally, we compare our proposed RD-VC scheduler with two important existing propositions: WTP (Waiting Time Priority) [2, 3] and EX-VC (Extended VirtualClock) [4]. Both these propositions are delay-based and have self-regulation property All three schedulers (RD-VC, WTP and EX-VC) maintain the required service differentiation among aggregates and have comparable long term average performance like mean throughput per aggregate and packet loss ratio etc. However, RD-VC and WTP take an edge over EX-VC at short-term performance like jitter. Both RD-VC and WTP have good long term and short-term performance. Our proposed RD-VC, compared to existing WTP, has two additional characteristics, i.e. unlike WTP which is limited to architectures with one queue per QoS class, it has no limitation on implementation scope (with or without separate queues per class) and it has lower complexity. This renders RD-VC an interesting proposition. [less ▲]

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