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See detailLe cas clinique du mois. Pemphigoide bulleuse apres brulure thermique.
Blaise, G.; Pierard, Claudine ULg; Quatresooz, Pascale ULg et al

in Revue Médicale de Liège (2008), 63(4), 182-3

In rare instances, some injuring physical factors such as thermal burns can be at the origin of bullous pemphigoid lesions. The early lesions are most often restricted to the injured skin area. Secondary ... [more ▼]

In rare instances, some injuring physical factors such as thermal burns can be at the origin of bullous pemphigoid lesions. The early lesions are most often restricted to the injured skin area. Secondary generalization is the natural evolution to be expected. However, once the episode is resolved, recurrence is exceptional. When the natural history of bullous pemphigoid differs from the regular type, the peculiar condition of development of these lesions does not change any of the diagnostic clinical and histological criteria, as well as the therapeutic procedures to follow. [less ▲]

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See detailMutational analysis of the zinc- and substrate-binding sites in the CphA metallo-beta-lactamase from Aeromonas hydrophila.
Bebrone, Carine ULg; Anne, Christine; Kerff, Frédéric ULg et al

in Biochemical Journal (2008), 414(1), 151-9

The subclass B2 CphA (Carbapenemase hydrolysing Aeromonas) beta-lactamase from Aeromonas hydrophila is a Zn(2+)-containing enzyme that specifically hydrolyses carbapenems. In an effort to evaluate ... [more ▼]

The subclass B2 CphA (Carbapenemase hydrolysing Aeromonas) beta-lactamase from Aeromonas hydrophila is a Zn(2+)-containing enzyme that specifically hydrolyses carbapenems. In an effort to evaluate residues potentially involved in metal binding and/or catalysis (His(118), Asp(120), His(196) and His(263)) and in substrate specificity (Val(67), Thr(157), Lys(224) and Lys(226)), site-directed mutants of CphA were generated and characterized. Our results confirm that the first zinc ion is in interaction with Asp(120) and His(263), and thus is located in the 'cysteine' zinc-binding site. His(118) and His(196) residues seem to be interacting with the second zinc ion, as their replacement by alanine residues has a negative effect on the affinity for this second metal ion. Val(67) plays a significant role in the binding of biapenem and benzylpenicillin. The properties of a mutant with a five residue (LFKHV) insertion just after Val(67) also reveals the importance of this region for substrate binding. This latter mutant has a higher affinity for the second zinc ion than wild-type CphA. The T157A mutant exhibits a significantly modified activity spectrum. Analysis of the K224Q and N116H/N220G/K224Q mutants suggests a significant role for Lys(224) in the binding of substrate. Lys(226) is not essential for the binding and hydrolysis of substrates. Thus the present paper helps to elucidate the position of the second zinc ion, which was controversial, and to identify residues important for substrate binding. [less ▲]

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See detailLe medicament du mois. Exenatide (Byetta). Incretinomimetique indique dans le traitement du diabete de type 2 apres echec et en complement des antidiabetiques oraux.
Scheen, André ULg; Van Gaal, L. F.

in Revue Médicale de Liège (2008), 63(3), 158-65

Exenatide (Byetta) is a synthetic derivative of exendin-4 and an agonist of receptors of glucagon-like peptide-1 (GLP-1). It is resistant to the rapid inactivation by dipeptidylpeptidase-4 and acts as an ... [more ▼]

Exenatide (Byetta) is a synthetic derivative of exendin-4 and an agonist of receptors of glucagon-like peptide-1 (GLP-1). It is resistant to the rapid inactivation by dipeptidylpeptidase-4 and acts as an incretin mimetic. It stimulates insulin secretion by the B cell in a glucose-dependent manner whereas it inhibits glucagon secretion. Exenatide improves mainly postprandial glucose concentrations and lowers glycated haemoglobin (HbA(1c)) levels, without being directly responsible for hypoglycaemia or requiring mandatory home blood glucose monitoring. Furthermore, it slows down gastric emptying and promotes sustained body weight reduction, even in absence of frequently reported nausea following treatment initiation. Exenatide is recommended and reimbursed in Belgium for the treatment of type 2 diabetes, in combination with metformin and a sulfonylurea, in patients not adequately controlled with maximal tolerated doses of these oral glucose-lowering agents. Exenatide is presented as pre-filled pens for subcutaneous injection. The recommended initial dose is 5 microg before morning and evening meals, to be up titrated to 10 microg twice daily. Exenatide may represent a valuable alternative to insulin therapy, especially in overweight or obese patients with type 2 diabetes and not ready to perform home blood glucose monitoring. [less ▲]

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See detailThorough analysis of input physics in CESAM and CLÉS codes
Montalban Iglesias, Josefa ULg; Lebreton, Yveline; Miglio, Andrea ULg et al

in Astrophysics & Space Science (2008), 316(1-4), 219-229

This contribution is not about the quality of the agreement between stellar models computed by CESAM and CLÉS codes, but more interesting, on what ESTA-Task 1 run has taught us about these codes and about ... [more ▼]

This contribution is not about the quality of the agreement between stellar models computed by CESAM and CLÉS codes, but more interesting, on what ESTA-Task 1 run has taught us about these codes and about the input physics they use. We also quantify the effects of different implementations of the same physics on the seismic properties of the stellar models, that in fact is the main aim of ESTA experiments. [less ▲]

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See detailFallopian tube insertion into the uterine cavity discovered accidentally during laparoscopic retrieval of a misplaced coil from the pelvic cavity
Panayotidis, Costas; Foidart, Jean-Michel ULg; Nisolle, Michelle ULg

in Gynecological Surgery (2008), 5(2), 125-7

This article presents for the first time in the literature a case of fallopian tube insertion into the uterine cavity discovered accidentally during laparoscopic retrieval of a misplaced coil from the ... [more ▼]

This article presents for the first time in the literature a case of fallopian tube insertion into the uterine cavity discovered accidentally during laparoscopic retrieval of a misplaced coil from the pelvic cavity. [less ▲]

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See detailA new design model for the resistance of steel semi-compact cross-sections
Boissonnade, N.; Jaspart, Jean-Pierre ULg; Oerder, R. et al

in Proceedings of EUROSTEEL 2008 (2008)

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See detailRapport 1 (comité de thèse)
Zirbes, Lara ULg

Report (2008)

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See detailBifidobacteria as indicators of faecal contamination along a sheep meat production chain
Delcenserie, Véronique ULg; Loncaric, D.; Bonaparte, Christine et al

in Journal of Applied Microbiology (2008), 104(1), 276-284

Aims: The potential use of bifidobacteria as indicators for faecal contamination was studied along a sheep meat production and processing chain. The levels of bifidobacteria were compared with those of ... [more ▼]

Aims: The potential use of bifidobacteria as indicators for faecal contamination was studied along a sheep meat production and processing chain. The levels of bifidobacteria were compared with those of Escherichia coli. Total viable counts were followed along the chain (244 samples). Methods and Results: Forty-three per cent of the samples contained bifidobacteria, of which 15% were solely detected using a PCR method based on the hsp60 gene and not by a culture-based method. Bifidobacteria were detected in only three of nine sheep faeces samples using one or the other method. However, carcasses (types C and E) were highly contaminated. These sample types (30% and 28%, respectively) were positive for bifidobacteria and negative for E. coli. The species Bifidobacterium pseudolongum and Bif. thermophilum, isolated from faecal samples, were predominant. Bifidobacterium choerinum were found in C, D, E and F sample types. Conclusions: Bifidobacteria were shown more efficient than E. coli in carcasses samples. The presence of Bif. choerinum suggested a faecal pork contamination. Significance and Impact of the Study: Detection and identification of bifidobacteria, in correlation with E. coli counting, should improve hygiene quality of mutton processing chains. [less ▲]

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See detailWest Gondwanan and Euramerican climate impact on Famennian miospore assemblages
Streel, Maurice ULg

in Subcommission on Devonian Stratigraphy Newsletter (2008), 23

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See detailRapid and easy development of versatile tools to study protein/ligand interactions
Vandevenne, Marylène ULg; Gaspard, Gilles ULg; Yilmaz, Nursel et al

in Protein engineering, design & selection (2008)

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See detailComment je traite... une intoxication au paracetamol.
Bertrand, Xavier ULg; Brasseur, Edmond ULg; Ghuysen, Alexandre ULg et al

in Revue Médicale de Liège (2008), 63(7-8), 465-8

Drug self-poisoning is a common cause of admission in ED. Among various incriminated substances, paracetamol is often implicated and presents a severe toxicity. We briefly describe the epidemiology and ... [more ▼]

Drug self-poisoning is a common cause of admission in ED. Among various incriminated substances, paracetamol is often implicated and presents a severe toxicity. We briefly describe the epidemiology and physiopathology of paracetamol self-poisoning. We then clarify the diagnostic elements, thresholds of toxicity, indications for treatment and different available therapeutic guidelines. [less ▲]

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See detailHypoxia is responsible for soluble vascular endothelial growth factor receptor-1 (VEGFR-1) but not for soluble endoglin induction in villous trophoblast
Munaut, Carine ULg; Lorquet, Sophie ULg; Pequeux, Christel ULg et al

in Human Reproduction (2008), 23(6), 1407-15

BACKGROUND: Pre-eclampsia is a pregnancy disorder characterized by a maternal endothelial cell dysfunction associated with low levels of circulating placental growth factor (PlGF) and increased levels of ... [more ▼]

BACKGROUND: Pre-eclampsia is a pregnancy disorder characterized by a maternal endothelial cell dysfunction associated with low levels of circulating placental growth factor (PlGF) and increased levels of total vascular endothelial growth factor (VEGF), soluble VEGF receptor-1 (sVEGFR-1), and soluble endoglin, a transforming growth factor b1 and 3 coreceptor. Here, we tested the hypothesis that these altered levels of angiogenic cytokines and of the anti-angiogenic soluble forms of cytokine receptors could be the consequence of hypoxia. METHODS: Normal human umbilical vein endothelial cells, immortalized first trimester extravillous trophoblast cells (HTR8/SVneo) and first trimester placental villi explants (8–14 weeks) were used for culture under normoxia (20% O2) or hypoxia (1% O2). Culture media were collected for the measurement of cytokines by enzyme-linked immunosorbent assay. Total RNA was extracted for RT-PCR analysis. RESULTS: Under hypoxia, villous trophoblast expressed higher levels of VEGF, VEGFR-1, sVEGFR-1 and VEGFR-2 mRNAs (P < 0.001), and secreted more VEGF and sVEGFR-1 proteins (P < 0.05). In contrast, PlGF mRNA and protein were decreased in 1% O2 (P < 0.001), whereas endoglin (Eng) was not modulated. Additionally, sVEGFR-1 directly abolished VEGF/PlGF-induced angiogenesis in the rat aortic ring assay. CONCLUSIONS: Our results support the hypotheses that, in pre-eclampsia, (i) overproduction of VEGF family factors by pre-eclamptic placenta is a consequence of induced hypoxia; (ii) overproduction of sVEGFR-1 by hypoxic villous trophoblast accounts for maternal free VEGF depletion; (iii) low circulating level of free PlGF is not only related to sVEGFR-1 overproduction, but also to hypoxia induced mRNA down-regulation; (iv) Eng is not modulated by hypoxia.. [less ▲]

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See detailLes approches de l'économie sociale et de l'économie solidaire face aux mutuelles de santé en Afrique
Defourny, Jacques ULg; Failon, Julie; Sarambe, Issa

E-print/Working paper (2008)

Ce papier examine dans quelle mesure les approches "économie sociale" et "économie solidaire" peuvent éclairer les réalités des mutuelles de santé en Afrique, mais aussi leurs limites respectives face à ... [more ▼]

Ce papier examine dans quelle mesure les approches "économie sociale" et "économie solidaire" peuvent éclairer les réalités des mutuelles de santé en Afrique, mais aussi leurs limites respectives face à ces pratiques de plus en plus répandues. [less ▲]

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See detailCooling by Time Reversal of Atomic Matter Waves
Martin, John ULg; Georgeot, B.; Shepelyansky, D. L.

in Physical Review Letters (2008), 100

We propose an experimental scheme which allows us to realized approximate time reversal of matter waves for ultracold atoms in the regime of quantum chaos. We show that a significant fraction of the atoms ... [more ▼]

We propose an experimental scheme which allows us to realized approximate time reversal of matter waves for ultracold atoms in the regime of quantum chaos. We show that a significant fraction of the atoms return back to their original state, being at the same time cooled down by several orders of magnitude. We give a theoretical description of this effect supported by extensive numerical simulations. The proposed scheme can be implemented with existing experimental setups. [less ▲]

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See detailToward an Optimal Design Procedure of a Nonlinear Vibration Absorber Coupled to a Duffing Oscillator
Viguié, Régis ULg; Kerschen, Gaëtan ULg

in International Conference on Noise and Vibration Engineering, Leuven, 2008 (2008)

In the present study, the focus is set on the development of a design methodology for nonlinear vibration absorbers, termed nonlinear energy sink (NES), to optimize the vibrating level reduction on a ... [more ▼]

In the present study, the focus is set on the development of a design methodology for nonlinear vibration absorbers, termed nonlinear energy sink (NES), to optimize the vibrating level reduction on a Duffing oscillator. The idea lies in the assessment of a duality property between, on the one hand, the tuning procedure of the tuned mass damper (TMD) coupled to a linear oscillator and, on the other hand, the assumed design scheme of NES coupled to a purely nonlinear Duffing oscillator. To this end, the basics on the TMD tuning methodology are recalled and extended to the concept of frequency-energy plot (FEP) [1]. Then, based upon this concept, the development of a NES design procedure is undertaken and the related dynamics analyzed. Finally, it is shown how to design a vibration absorber to deal with a general Duffing oscillator. [less ▲]

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See detailOperational Modal Analysis using Second-Order Blind Identification
Poncelet, Fabien ULg; Kerschen, Gaëtan ULg; Golinval, Jean-Claude ULg

in 26th International Modal Analysis Conference, Orlando, 2008 (2008)

For modal analysis of large structures, it is unpractical and expensive to use artificial excitation (e.g., shakers). However, engineering structures are most often subject to ambient loads (e.g., traffic ... [more ▼]

For modal analysis of large structures, it is unpractical and expensive to use artificial excitation (e.g., shakers). However, engineering structures are most often subject to ambient loads (e.g., traffic and wind) that can be exploited for modal parameter estimation. One difficulty is that the actual loading conditions cannot generally be measured, and output-only measurements are available. This paper proposes to explore the utility of blind source separation (BSS) techniques for operational modal analysis. The basic idea of BSS is to recover unobserved source signals from their observed mixtures. The feasibility and practicality of the proposed method are demonstrated using an experimental application. [less ▲]

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