Publications ORBi OA
Bookmark and Share    
Full Text
Peer Reviewed
See detailComment je préviens...les cancers cutanés: entre information et syndrome "telly belly".
Pierard, Claudine ULg; Henry, Frédérique ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2004), 59(1), 5-7

During the past decades, the incidence of skin cancers has been on the rise in Wallonia as in other regions of similar latitude in the rest of the world. Awareness of the population to the dangers of sun ... [more ▼]

During the past decades, the incidence of skin cancers has been on the rise in Wallonia as in other regions of similar latitude in the rest of the world. Awareness of the population to the dangers of sun exposure and to the benefit of early cancer diagnosis is of the upmost importance and undisputed. The impact of the information delivered by the media and of the actions initiated by physicians is heterogeneous. The positive and unquestionable aspect is hampered if the population at risk is not properly targeted. It is also reduced if the problem understanding creates a surge in telly-belly syndrome. [less ▲]

Detailed reference viewed: 33 (0 ULg)
Full Text
Peer Reviewed
See detailComment j'explore ... les dermites des langes.
Flagothier, Caroline ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2004), 59(2), 106-9

Diaper dermatitis is a frequent condition. Several clinical types are distinguished. The most frequent type results from increased fragility of the newborn buttock skin when covered by diapers. According ... [more ▼]

Diaper dermatitis is a frequent condition. Several clinical types are distinguished. The most frequent type results from increased fragility of the newborn buttock skin when covered by diapers. According to the mechanisms involved and the severity of the dermatitis, one can distinguish the intertrigo of the chubby baby, and the so-called "W", "Y" and "red panties" types of diaper dermatitis. When the effects of occlusion are not controlled by adequate absorption by the diapers, hyperhydration of the stratum corneum occurs and progresses to maceration. As a result, the value of the coefficient of friction of the skin increases with epidermal weakening to rubbing. In addition, fecal enzymes (urease, proteases and lipases) alter urines and skin. Judicious hygiene measures and the correct choice of diapers are mandatory. Cutaneous colonization by microorganisms, the most important of which being Candida albicans, is the main complication. Adequate preventive and curative measures can combat diaper dermatitis with confidence. A miconazole paste allows to improve the tribological properties of the interface between diapers and the skin. It also abates the impact of Candida albicans in the pathogenesis of the skin disorder. [less ▲]

Detailed reference viewed: 75 (0 ULg)
Full Text
Peer Reviewed
See detailAlignment of glial cells stimulates directional neurite growth of cns neurons in vitro
Deumens, R.; Koopmans, G. C.; Den Bakker, C. G. J. et al

in Neuroscience (2004), 125(3), 591-604

Olfactory ensheathing cells (OECs) together with olfactory nerve fibroblasts (ONFs) and neonatal astrocytes are potent stimulators of neurite growth in adulthood and during development, respectively ... [more ▼]

Olfactory ensheathing cells (OECs) together with olfactory nerve fibroblasts (ONFs) and neonatal astrocytes are potent stimulators of neurite growth in adulthood and during development, respectively. Since it is known that alignment of glial cells is important for the correct outgrowth of axon tracts, it was hypothesized that the alignment of glial cells stimulates directional and enhanced neurite outgrowth. Adult OEC/ONF and neonatal astrocytes were cultured either on biodegradable poly(D,L)-lactide matrices or in Petri dishes for 4 days. Thereafter neonatal cerebral cortical neurons were added. After a 2-days coculture period the cultures were fixed and processed for a combined MAP-2 and phosphorylated neurofilament (RT97) staining. The neurite growth (neurite elongation and neurite formation) and the neurite direction were assessed. We show that (1) OEC/ONF cultures are more potent in stimulating the length of the longest neurite of cocultured neurons, (2) alignment of glial is achieved in vitro on our biomatrices, (3) aligned glial/biomatrix complexes do not enhance neurite growth, and (4) aligned glial/biomatrix complexes direct neurite outgrowth. These data have significant implications for in vivo experiments focusing on glial transplantation. Transplanting glial/biomatrix complexes may stimulate the directional regrowth of severed axons across a lesion site. (C) 2004 IBRO. Published by Elsevier Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 40 (2 ULg)
Full Text
See detailEXPLOITATION DES DONNEES DU DOSSIER DE SANTE INFORMATISE EN SOINS PRIMAIRES. RESISTANCES ET SOLUTIONS. ETUDE DANS HUIT MAISONS MEDICALES WALLONNES
Vanmeerbeek, Marc ULg

Master of advanced studies dissertation (2004)

Introduction : Le dossier de santé informatisé (DSI), utilisé quotidiennement en soins primaires, peut constituer un instrument de récolte de données utilisables localement pour l’amélioration de la ... [more ▼]

Introduction : Le dossier de santé informatisé (DSI), utilisé quotidiennement en soins primaires, peut constituer un instrument de récolte de données utilisables localement pour l’amélioration de la qualité des soins et, à une plus grande échelle, une base de données épidémiologiques. Malgré une politique de promotion du DSI de la Fédération des Maisons médicales belges francophones, son utilisation reste très marginale. Méthodes : Huit maisons médicales motivées par l’informatisation de leur dossier ont été rencontrées. Des indicateurs quantitatifs d’utilisation du DSI ont été mesurés. Une évaluation qualitative des résistances à l’informatisation et des solutions pouvant y être apportées a été réalisée par la technique du groupe nominal. Résultats : L’utilisation du DSI reste faible, sauf exception. Les solutions proposées ont pu être regroupées en 5 catégories : éthique (confidentialité, relation avec le patient, relation du thérapeute avec la machine), formation (à l’informatique, à la logique classificatoire, formation accessible), recherche de sens (envie d’utiliser les outputs locaux dans des projets d’amélioration de la qualité des soins, comparaison avec d’autres praticiens, encadrement local), pratique (amélioration du logiciel, amélioration de l’organisation interne des équipes, gestion du temps passé à l’encodage des données) et pluridisciplinarité (coordination entre secteurs, effort soutenu par l’ensemble de l’équipe, projets communs). Discussion : Les praticiens sont prêts à s’informatiser s’ils en retirent des bénéfices immédiats (connaissance de leur patientèle et de leur fonctionnement d’équipe). Ils ont exprimé le besoin de disposer d’un outil simple à utiliser, qui ne leur fasse pas perdre de temps et qui respecte leurs spécificités de travail et d’organisation (équipe pluridisciplinaires et autogérées). Ils ont exprimé le besoin d’un soutien extérieur, sous forme de formations adaptées et d’encadrement pour la gestion des données. Les préoccupations de type éthique (sécurité, transfert de données, place de l’ordinateur dans la relation avec le patient) sont étonnamment peu présentes. [less ▲]

Detailed reference viewed: 95 (15 ULg)
Full Text
See detailThe Photoionization Mass Spectrometric Study of the Three membered Ring Systems C3H6, C2H4O and C2H4S and their open Chain Isomers.
Locht, Robert ULg; Leyh, Bernard ULg; Jochims, H.-W. et al

Book published by Berliner Elektronen Speicherring für Synchrotron Strahlung m.b.H - on CD-ROM (2004)

The dissociative photoionization mass spectrometric study of C2H6, C2H4O and C2H4S has been measured using synchrotron radiation. The ionization efficiency curves of the molecular ions of the three ... [more ▼]

The dissociative photoionization mass spectrometric study of C2H6, C2H4O and C2H4S has been measured using synchrotron radiation. The ionization efficiency curves of the molecular ions of the three species are reported. [less ▲]

Detailed reference viewed: 30 (0 ULg)
Full Text
Peer Reviewed
See detailCervical artery dissection: An atypical presentation with Ehlers-Danlos-like collagen pathology?
Ulbricht, D.; Diederich, N. J.; Hermanns-Le, Trinh ULg et al

in Neurology (2004), 63(9), 1708-10

The authors took skin biopsies of the macroscopically normal skin of seven consecutive patients with spontaneous cervical artery dissection (SCAD). Histologically, alterations of the collagen and elastic ... [more ▼]

The authors took skin biopsies of the macroscopically normal skin of seven consecutive patients with spontaneous cervical artery dissection (SCAD). Histologically, alterations of the collagen and elastic fiber networks were found in six patients. In five, the histologic, immunohistochemical, and ultrastructural changes were similar to those usually found in Ehlers-Danlos syndrome (EDS). This suggests that SCAD is frequently associated with the dermal alterations seen in EDS. [less ▲]

Detailed reference viewed: 19 (1 ULg)
Full Text
Peer Reviewed
See detailLe cas clinique du mois. La syphilis, une MST de retour en nos murs.
Flagothier, Caroline ULg; Arrese Estrada, Jorge ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2004), 59(7-8), 426-9

Sexually transmitted diseases (STD) show frequent epidemiological changes. We report a case of secondary syphilis diagnosed in a 32-year old woman during post-partum. The disease, although showing a ... [more ▼]

Sexually transmitted diseases (STD) show frequent epidemiological changes. We report a case of secondary syphilis diagnosed in a 32-year old woman during post-partum. The disease, although showing a typical presentation, raises the problem of dating with precision the contamination time. This is of importance for treating the newborn at risk of congenital syphilis. We highlight the constant attention that should be brought to disclose this venereal disease that shows so variable clinical and histological presentations. Syphilis seems on the rise in the Mosan valley and in some cities where prostitution is imported from Eastern Europe and Africa. [less ▲]

Detailed reference viewed: 217 (2 ULg)
Full Text
Peer Reviewed
See detailLes toxidermies paroxystiques graves.
Paquet, Philippe ULg; Flagothier, Caroline ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2004), 59(5), 286-92

Some drug reactions showing cutaneous expression exhibit a paroxysmal course. These diseases encompass the toxic epidermal necrolysis, the drug hypersensitivity syndrome, and the acute generalized ... [more ▼]

Some drug reactions showing cutaneous expression exhibit a paroxysmal course. These diseases encompass the toxic epidermal necrolysis, the drug hypersensitivity syndrome, and the acute generalized exanthematic pustulosis. These syndromes are associated with dismal outcome. They represent medical emergencies needing hospitalization in specialized care units. [less ▲]

Detailed reference viewed: 98 (8 ULg)
Full Text
Peer Reviewed
See detailComment je traite...un psoriasis du cuir chevelu.
Uhoda, I.; Flagothier, Caroline ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2004), 59(9), 481-4

Scalp involvement by psoriasis requires a ted treatment suited to the particularities of the anatomical site In course of time, the improvement of therapeutic agents and the galenic refinement have ... [more ▼]

Scalp involvement by psoriasis requires a ted treatment suited to the particularities of the anatomical site In course of time, the improvement of therapeutic agents and the galenic refinement have enhanced both the efficacy and cosmetic acceptability of the scalp care. The main therapeutic classes encompass keratolytics, dermocorticosteroids and vitamine D3 analogues. The patient compliance is reported to be best for the liquid or foam formulations. [less ▲]

Detailed reference viewed: 152 (6 ULg)
Full Text
Peer Reviewed
See detailComment j'explore... une perte de cheveux chez un patient cancéreux.
Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2004), 59(9), 525-9

Increased hair loss followed, in some instances by an acute focal or total alopecia, can develop in some cancer patients. The surgical stress or procedure, radiotherapy and some chemotherapy regimens can ... [more ▼]

Increased hair loss followed, in some instances by an acute focal or total alopecia, can develop in some cancer patients. The surgical stress or procedure, radiotherapy and some chemotherapy regimens can be responsible for these disturbing events. The alopecia is transient or permanent according to its origin. Diverse diagnostic and prognostic methods are available for assessing alopecias. The trichogram is a rewarding one. [less ▲]

Detailed reference viewed: 43 (1 ULg)
Full Text
Peer Reviewed
See detailLe cas clinique du mois. Fasciolase cutanée.
Garcia Moreno Rodriguez, Renata ULg; Arrese Estrada, Jorge ULg; Ugarte, G. et al

in Revue Médicale de Liège (2004), 59(10), 552-4

Fascioliasis is an hepato-biliary distomatosis which may exceptionally manifest itself in the skin. We report a case presenting as nodules localized on the trunk. Lesions cleared under praziquantel ... [more ▼]

Fascioliasis is an hepato-biliary distomatosis which may exceptionally manifest itself in the skin. We report a case presenting as nodules localized on the trunk. Lesions cleared under praziquantel treatment. [less ▲]

Detailed reference viewed: 418 (5 ULg)
Full Text
Peer Reviewed
See detailCoping with mild inflammatory catamenial acne: a clinical and bioinstrumental split-face assessment.
Petit, Ludivine; Pierard, Claudine ULg; Uhoda, Emmanuelle ULg et al

in Skin Research & Technology (2004), 10(4), 278-82

BACKGROUND: Acne is a multifactorial disease exhibiting distinct clinical presentations. Among them, the catamenial type is a matter of concern for young women. Some oral contraceptives may help without ... [more ▼]

BACKGROUND: Acne is a multifactorial disease exhibiting distinct clinical presentations. Among them, the catamenial type is a matter of concern for young women. Some oral contraceptives may help without, however, clearing the skin condition. AIM: The present open study aimed at evaluating the effect of overnight applications of a paste made of petrolatum,15% zinc oxide and 0.25% miconazole nitrate. METHOD: The split-face trial was conducted in 35 women. A non-medicated cream was used as control. Clinical evaluations and biometrological assessments on cyanoacrylate follicular biopsies were performed monthly for 3 months. Comedometry and the density in autofluorescent follicular casts were used as analytical parameters. In addition, the five most severe cases at inclusion were tested at the completion of the study for follicular bacterial viability using dual flow cytometry. RESULTS: Compared with baseline and to the control hemi-face, the medicated paste brought significant improvement of acne. The number of papules and their redness were reduced beginning with the first treatment phase. A reduction in the follicular fluorescence was yielded beginning with the second treatment phase. The ratios between injured and dead bacteria, on the one hand, and live bacteria, on the other hand were significantly increased at completion of the study. CONCLUSION: A miconazole paste applied for 1 week at the end of the ovarian cycle has a beneficial effect on catamenial acne. [less ▲]

Detailed reference viewed: 32 (0 ULg)
Full Text
Peer Reviewed
See detailLe cas clinique du mois. Purpura révélateur d'un rhumatisme articulaire aigu.
Fumal, I.; Henry, Frédérique ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2004), 59(11), 630-2

We report the case of an adult who presented cutaneous manifestations of rheumatic fever. The lesions are rarely diagnosed. However, they represent a clue inciting a specific diagnostic search for ... [more ▼]

We report the case of an adult who presented cutaneous manifestations of rheumatic fever. The lesions are rarely diagnosed. However, they represent a clue inciting a specific diagnostic search for identifying the disease. [less ▲]

Detailed reference viewed: 54 (1 ULg)
Full Text
See detailPublicité, clauses abusives, recouvrement amiable de créances et déontologie
Orban, Lionel ULg; Bar, Stéphanie

in Cahiers de déontologie – Evolutions récentes et applications pratiques » - Volume 2, Actes du Colloque du 14 mai 2004, Ordre des avocats des Barreaux de Liège et de Verviers (2004)

Detailed reference viewed: 63 (7 ULg)
Full Text
Peer Reviewed
See detailInfo-congres. Effets d'une insulinotherapie intensive apres un infarctus du myocarde chez le patient diabetique de type 2 : resultats de l'etude DIGAMI-2.
Scheen, André ULg; Radermecker, Régis ULg; Philips, Jean-Christophe ULg

in Revue Médicale de Liège (2004), 59(9), 534-9

The results of DIGAMI-2 (<<Diabetes Mellitus Insulin Glucose Infusion in Acute Myocardial Infarction>>) trial were presented at the 40th scientific congress of the European Association for the Study of ... [more ▼]

The results of DIGAMI-2 (<<Diabetes Mellitus Insulin Glucose Infusion in Acute Myocardial Infarction>>) trial were presented at the 40th scientific congress of the European Association for the Study of Diabetes (EASD) in Munich on September 6, 2004. The main objective of this multicentre international trial was to confirm the positive results of the first DIGAMI trial published in 1995--1997. This pilot trial demonstrated that insulin-glucose infusion followed by a subcutaneous multidose insulin regimen reduces total mortality after 1 and 3 years in diabetic patients with acute myocardial infarction. DIGAMI-2, by comparing three groups of subjects receiving various interventions, aimed at determining the relative benefit resulting from the insulin-glucose infusion in the acute phase and that attributable to long-term intensive insulin therapy in a similar population of type 2 diabetic patients. No significant difference was observed between the three groups as far as total mortality and cardiovascular morbidity were concerned. These negative results may be explained by the absence of significant difference in blood glucose control between the three groups, by the fact that glycaemic targets were not reached in the intensive group and, last but not least, by a better management of other risk factors, allowing already markedly reduced cardiovascular morbidity and mortality in the reference group treated with conventional antidiabetic therapy. In conclusion, DIGAMI-2 argues for a multidisciplinary management of diabetic patients to reach strict glycaemic targets with an intensive insulin scheme and confirms the remarkable advances in cardiovascular protection thanks to an optimised global pharmacological approach combined with modern revascularisation procedures. [less ▲]

Detailed reference viewed: 53 (4 ULg)
Full Text
Peer Reviewed
See detailComment j'explore...le risque cardio-vasculaire absolu a 10 ans: de Framingham 1998 a SCORE 2003.
Scheen, André ULg

in Revue Médicale de Liège (2004), 59(7-8), 460-6

Prevention of cardiovascular diseases should primarily focus on high-risk individuals. In the absence of atherosclerosis manifestations, such persons may be screened by the calculation of the absolute ... [more ▼]

Prevention of cardiovascular diseases should primarily focus on high-risk individuals. In the absence of atherosclerosis manifestations, such persons may be screened by the calculation of the absolute risk of complications during the next ten years or extrapolated at the age of 60 years. This calculation is based upon the analysis of most important risk factors of atherosclerosis. The mode of calculation that prevailed for many years used the Framingham equation determining the absolute coronary risk (both morbidity and mortality) in the next 10 years: a risk equal or superior to 20% is considered as high and requiring specific intervention. The Third Joint Task Force of European and other Societies on cardiovascular disease prevention in clinical practice recently proposed a new mode of calculation (SCORE) based upon the absolute risk of cardiovascular (and not exclusively coronary) mortality (only fatal events and not morbidity): according to SCORE, the threshold of high risk has been set at a risk equal or superior to 5% in the next 10 years. The present article compares the two modes of calculation with their own advantages and disadvantages. [less ▲]

Detailed reference viewed: 613 (1 ULg)
Full Text
Peer Reviewed
See detailInfo-congres. Optimalisation de la prise en charge du patient diabetique: une selection de quelques essais cliniques presentes au Congres 2004 de l'American Diabetes Association.
Scheen, André ULg; Radermecker, Régis ULg; Philips, Jean-Christophe ULg

in Revue Médicale de Liège (2004), 59(6), 407-12

The 64th scientific congress of the American Diabetes Association had a special session devoted to the presentation of the results from three clinical trials: 1) the first multicentre international trial ... [more ▼]

The 64th scientific congress of the American Diabetes Association had a special session devoted to the presentation of the results from three clinical trials: 1) the first multicentre international trial of pancreatic islet transplantation according to the so-called Edmonton protocol with the primary endpoint of restoring insulin independence in type 1 diabetic patients; 2) three pivotal studies of 30 weeks testing both the efficacy and safety of exenatide (exendin-4), a new insulin secretagogue that is a long-acting analogue of glucagon-like peptide-1, in patients with type 2 diabetes treated with either metformin, or a sulfonylurea, or a metformin-sulfonylurea combination; and 3) the "Collaborative AtoRvastatin Diabetes Study" (CARDS), a placebo-controlled primary prevention trial of cardiovascular complications using atorvastatin 10 mg in 2 838 at risk patients with type 2 diabetes. The main results and conclusions of these trials are briefly presented as they open new perspectives in the management of patients with type 1 or type 2 diabetes mellitus. [less ▲]

Detailed reference viewed: 22 (2 ULg)
Full Text
Peer Reviewed
See detailActualites therapeutiques 2003-2004.
Scheen, André ULg

in Revue Médicale de Liège (2004), 59(6), 385-402

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The main characteristics of each molecule and ... [more ▼]

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The main characteristics of each molecule and its modalities of appropriate use in clinical practice will be emphasized. Both the efficacy and safety of these new drugs have been evaluated in randomised controlled trials according to the evidence-based-medicine criteria. Most of them are currently studied in order to further demonstrate their potential benefit on a long-term basis, in large cohort of patients and using hard clinical endpoints. [less ▲]

Detailed reference viewed: 42 (0 ULg)
Full Text
Peer Reviewed
See detailLe coma hypoglycemique, un phenomene paroxystique redoute chez le patient diabetique de type 1.
Radermecker, Régis ULg; Scheen, André ULg

in Revue Médicale de Liège (2004), 59(5), 265-9

The hypoglycaemic coma is a severe complication for type 1 diabetic patients. Rarely fatal it may be associated with various paroxysmal accidents, potentially harmful, especially during driving ... [more ▼]

The hypoglycaemic coma is a severe complication for type 1 diabetic patients. Rarely fatal it may be associated with various paroxysmal accidents, potentially harmful, especially during driving. Hypoglycaemia certainly alters the quality of life because it markedly increases the anxiety of both the patient and his/her family. It is considered as a major limiting factor in the glycaemic management of type 1 diabetic patients. Being the consequence of numerous causal factors, hypoglycaemic coma is not always easy to prevent and may occur as a paroxysmal phenomenon, sometimes without obvious contributing circumstances. After having defined the various hypoglycaemic thresholds, we will analyse the pathophysiology of insulin-induced hypoglycaemia and of its hormonal counterregulation, and we will describe the hypoglycaemia unawareness phenomenon. These elements should help to better understand why a hypoglycaemic coma may suddenly occur in a diabetic patient. Some advices will also be given to reduce the risk of such a paroxysmal complication in patients with type 1 diabetes. [less ▲]

Detailed reference viewed: 112 (5 ULg)
Full Text
Peer Reviewed
See detailLe medicament du mois. Ezetimibe (Ezetrol).
Scheen, André ULg

in Revue Médicale de Liège (2004), 59(4), 246-50

Ezetimibe (Ezetrol), recently launched in Belgium by Merck Sharp& Dohme and Schering Plough, is presented as 10 mg tablets. It belongs to a new class of lipid-lowering agents that selectively inhibit the ... [more ▼]

Ezetimibe (Ezetrol), recently launched in Belgium by Merck Sharp& Dohme and Schering Plough, is presented as 10 mg tablets. It belongs to a new class of lipid-lowering agents that selectively inhibit the intestinal absorption of cholesterol and phytosterols. Its mechanism of action results in a synergistic cholesterol-lowering effect together with a statin that inhibits cholesterol synthesis by the liver. Ezetimibe, at a daily dose of 10 mg, is indicated, in combination with a statin, as adjuvant treatment to diet in patients with primary hypercholesterolaemia (homozygote or heterozygote familial form and non-familial polygenic form) not well controlled with a statin alone. In case of statin contra-indication or intolerance, ezetimibe can be used in monotherapy. Its tolerance profile is excellent. Statin-ezetimibe combination allows to significantly reduce total and LDL cholesterol levels and increases the percentage of hypercholesterolaemic patients who will reach the target levels recommended in the international guidelines against atherosclerosis. However, such a combination should still prove its efficacy in reducing cardiovascular morbidity and mortality in large prospective clinical trials. [less ▲]

Detailed reference viewed: 105 (1 ULg)