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See detailDeterminants of an abnormal response to exercise in patients with asymptomatic valvular aortic stenosis.
Lancellotti, Patrizio ULg; Karsera, Danai; Tumminello, Gabriele et al

in European Journal of Echocardiography (2008), 9(3), 338-43

AIM: Patients with asymptomatic aortic stenosis (AS) and abnormal haemodynamic responses to exercise testing are at increased risk of cardiac events. This study assesses the Doppler echocardiographic ... [more ▼]

AIM: Patients with asymptomatic aortic stenosis (AS) and abnormal haemodynamic responses to exercise testing are at increased risk of cardiac events. This study assesses the Doppler echocardiographic determinants of a positive exercise test in a cohort of asymptomatic patients with AS. METHODS AND RESULTS: One hundred and twenty-eight patients with AS underwent quantitative Doppler echocardiographic measurements at rest and during exercise test. Of these patients, 60 had an abnormal response to exercise. Two independent determinants of an abnormal exercise response were selected in multivariate analysis: a larger increase in mean transaortic pressure gradient (P = 0.00014) and a limited contractile reserve-latent left ventricular dysfunction-as indicated by smaller changes in ejection fraction (P = 0.0002). Limiting symptoms were associated with greater increase in mean transaortic pressure gradient, smaller changes in systolic blood pressure and a lower ejection fraction at peak exercise. The increase in pressure gradient was associated with smaller exercise-induced changes in aortic valve area and in ejection fraction and new or worsening mitral regurgitation during exercise. CONCLUSION: Abnormal responses to exercise in asymptomatic AS patients are mediated by a larger increase in mean transaortic pressure gradient and/or a limited contractile reserve characterized by an inadequate increase in ejection fraction at exercise. [less ▲]

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See detailGermline PTPN11 missense mutation in a case of Noonan syndrome associated with mediastinal and retroperitoneal neuroblastic tumors.
Mutesa, Léon; Pierquin, Geneviève ULg; Janin, Nicolas ULg et al

in Cancer Genetics & Cytogenetics (2008), 182(1), 40-2

Noonan syndrome (NS) is an autosomal dominant disorder characterized by short stature, typical craniofacial dysmorphism, skeletal anomalies, congenital heart defects, and predisposition to malignant ... [more ▼]

Noonan syndrome (NS) is an autosomal dominant disorder characterized by short stature, typical craniofacial dysmorphism, skeletal anomalies, congenital heart defects, and predisposition to malignant tumors. In approximately 50% of cases, the disease is caused by missense mutations in the PTPN11 gene. To date, solid tumors, and particularly brain tumors and rhabdomyosarcomas, have been documented in patients with NS; however, few cases of neuroblastoma associated with NS have been reported. Here we report an unusual case of neuroblastoma with mediastinal, retroperitoneal, and medullar locations associated in a NS patient carrying a PTPN11 germline missense mutation (p.G60A). This missense mutation occurs within the N-SH2 domain of the PTPN11 gene and has been reported to be associated with acute leukemia in NS patients. The association of this p.G60A PTPN11 mutation with neuroblastoma provides new evidence that gain of function PTPN11 mutations may play an important role in the pathogenesis of solid tumors associated with Noonan syndrome. [less ▲]

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See detailChromosomal profiles of gene expression in Huntington's disease.
Anderson, Alexander N; Roncaroli, Federico; Hodges, Angela et al

in Brain : A Journal of Neurology (2008), 131(Pt 2), 381-8

Recent studies suggested that Huntington's disease is due to aberrant interactions between mutant huntingtin protein, transcription factors and transcriptional co-activators resulting in widespread ... [more ▼]

Recent studies suggested that Huntington's disease is due to aberrant interactions between mutant huntingtin protein, transcription factors and transcriptional co-activators resulting in widespread transcriptional dysregulation. Mutant huntingtin also interacts with histone acetyltransferases, consequently interfering with the acetylation and deacetylation states of histones. Because histone modifications and chromatin structure coordinate the expression of gene clusters, we have applied a novel mathematical approach, Chromowave, to analyse microarray datasets of brain tissue and whole blood to understand how genomic regions are altered by the effects of mutated huntingtin on chromatin structure. Results show that, in samples of caudate and whole blood from Huntington's disease patients, transcription is indeed deregulated in large genomic regions in coordinated fashion, that transcription in these regions is associated with disease progression and that altered chromosomal clusters in the two tissues are remarkably similar. These findings support the notion of a common genome-wide mechanism of disruption of RNA transcription in the brain and periphery of Huntington's disease patients. [less ▲]

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See detailServices de proximité et régulation publique
Henry, Arnaud ULg

in Non-marchand (2008), 6

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See detailCaracterización y cuantificación autmatizadas de menas metálicas mediante visión artificial : proyecto cameva
Castroviejo, Ricardo; Catalina, Juan-Carlos; Bernhardt, Heinz-Juergen et al

in Actos del XIII Congreso Latino Americano de Geologia (2008)

The CAMEVA project (Automated system for the identification and quantitative measurement of ore minerals) aims to develop an automated system able to perform the identification and quantification of the ... [more ▼]

The CAMEVA project (Automated system for the identification and quantitative measurement of ore minerals) aims to develop an automated system able to perform the identification and quantification of the different minerals present in a sample of metallic ores, in order to facilitate their industrial use. The system comprises a motorised reflected light microscope, a filter wheel (monochromator), a research BW camera, and a computer running a digital image analysis software associated to an expert system specially developed for this application. Multispectral reflectance values are measured for visible light and near IR and UV (350-1000 nm), and no polarisation is usually employed in order to reduce measurement variability due to mineral anisotropy. Mineral identification is carried out by comparison of measured reflectances with spectral reflectance databases (e.g. IMA-COM). Previous experiences showed that the most common ores can be differentiated through the analysis of a microscopic RGB colour image, by constraining the search with additional information such as the type of deposit and the corresponding mineral association. The project goes further, and intends to identify most of the ores from multi-spectral images, including non-visible bands, resorting to an expert system specifically built to deal with the different types of information available (spectral reflectance, sample origin, mineral associations, morphology, etc). 2 Validation of the method will be carried out by comparative análisis of standards and samples exchanged between the laboratories. Development pays special attention to the total automation of the process (including calibration) and to the self-learning capabilities of the system. Contacts with research institutions and with the industry will allow to apply the system to real problems. The system can be used to control the processing of ores as well as to prevent pollution for the protection of the environment (e.g. sulphides in coal or in industrial tailings). Further applications can be envisaged in the future: e.g. other minerals, coal or materials, particles, etc. [less ▲]

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See detailLa France et l'OTAN : vers la normalisation ?
Dumoulin, André ULg

in Courrier Hebdomadaire du CRISP (2008), 2005

En 1966, la France se retire du commandement intégré de l’OTAN. Son actuelle réintégration n’est pas une rupture ni le fruit d’une révolution spectaculaire récente, mais plutôt l’aboutissement d’un ... [more ▼]

En 1966, la France se retire du commandement intégré de l’OTAN. Son actuelle réintégration n’est pas une rupture ni le fruit d’une révolution spectaculaire récente, mais plutôt l’aboutissement d’un processus engagé par François Mitterrand et poursuivi par Jacques Chirac. En fait, la politique française a toujours joué sur plusieurs plans, entre indépendance nationale, soutien à la défense européenne et engagements au sein de l’Alliance. La dimension « autonomie européenne » a toujours fait l’objet du soutien important de la part de Paris, avec des résultats qui ne furent pas toujours à la hauteur des ambitions. Depuis la fin de la Guerre froide et le 11 septembre 2001, le paysage a changé. Les États-Unis ont compris que sans les Européens, il n’y a pas beaucoup d’alliés sur qui compter pour disposer d’une armée crédible et qui s’engage sur le terrain. De son côté, Paris a pris des initiatives pragmatiques sur des dossiers opérationnels, techniques et militaires durant la présidence du Conseil de l’Union européenne au second semestre 2008, sortant ainsi des grands concepts idéologiques européistes. Le dossier examine la dimension historique de la place de la France dans l’organisation euro-atlantique, l’évolution de la position hexagonale dans les années 1990, les débats engagés entre 2007 et 2009, les argumentaires (favorables et négatifs) des partis politiques, les hypothèses et les scénarios à propos de la « normalisation » française autour du sommet de l’Alliance atlantique à Strasbourg-Kehl en avril 2009. [less ▲]

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See detailHolocene records of regional dust deposition using peat bogs
Le Roux, G.; De Vleeschouwer, François; Cheburkin, A. et al

in Geochimica et Cosmochimica Acta (2008), 72(12), 535-535

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See detailSerum dioxin and PCB levels among PCB waste processing plant workers
Eppe, Gauthier ULg; Dupas, D.; Chisacof, I. et al

in Organohalogen Compounds (2008), 70

A clinical investigation and a biological monitoring were carried out to evaluate the occupational exposure of workers in contact with pyralen in a PCB-transformer and capacitor decontamination plant in ... [more ▼]

A clinical investigation and a biological monitoring were carried out to evaluate the occupational exposure of workers in contact with pyralen in a PCB-transformer and capacitor decontamination plant in France. The aim of this study was to assess the body burden of polychlorinated dibenzo-p- dioxin (PCDDs), polychlorinated dibenzofurans (PCDFs), dioxin-like (DL) PCBs and marker PCBs for those workers. We examined 8 representative workers (34-44 years old). The subjects of this study worked from 5 years to 19 years at the plant. All workers reported daily multiple contacts with various metal and wood parts of dismantled transformers during working hours. On a yearly basis, the exposed subjects were examined by the occupational health physician for a check-up. Basic parameters such as liver function and lipid statement were performed. [less ▲]

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See detailLevels of PCDD/Fs and DL-PCBs in Belgian river eel specimen
Focant, Jean-François ULg; Geererts, C.; Eppe, Gauthier ULg et al

in Organohalogen Compounds (2008), 70

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See detailThe wave function of $[70,1^-]$ baryons in the $1/N_c$ expansion
Matagne, Nicolas; Stancu, Floarea ULg

in Phys. Rev. (2008), D77

Much work has been devoted to the study of nonstrange baryons belonging to the $[\textbf{70},1^-]$ multiplet in the framework of the $1/N_c$ expansion. Using group theoretical arguments here we examine ... [more ▼]

Much work has been devoted to the study of nonstrange baryons belonging to the $[\textbf{70},1^-]$ multiplet in the framework of the $1/N_c$ expansion. Using group theoretical arguments here we examine the relation between the exact wave function and the approximate one, customarily used in applications where the system is separated into a ground state core and an excited quark. We show that the exact and approximate wave functions globally give similar results for all of mass operators presented in this work. However we find that the inclusion of operators acting separately on the core and on the excited quark deteriorates the fit and leads to unsatisfactory values for the coefficients which encode the quark dynamics. Much better results are obtained when we include operators acting on the whole system, both for the exact and the approximate wave function. [less ▲]

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See detailNew look at the (70,1-) baryon multiplet in the 1/N(c) expansion
Matagne, Nicolas; Stancu, Floarea ULg

in Nucl. Phys. (2008), A811

So far, the masses of excited states of mixed orbital symmetry and in particular those of nonstrange $[{\bf 70},1^-]$ baryons derived in the $1/N_c$ expansion were based on the separation of a system of ... [more ▼]

So far, the masses of excited states of mixed orbital symmetry and in particular those of nonstrange $[{\bf 70},1^-]$ baryons derived in the $1/N_c$ expansion were based on the separation of a system of $N_c$ quarks into a symmetric core and an excited quark. Here we avoid this separation and show that an advantage of this new approach is to substantially reduce the number of linearly independent operators entering the mass formula. A novelty is that the isospin-isospin term becomes as dominant in $\Delta$ as the spin-spin term in $N$ resonances. [less ▲]

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See detailVerslagen & Mededelingen van de Koninklijke Academie voor Nederlandse Taal- en Letterkunde. Themanummer "Recente ontwikkelingen in het contrastief taalonderzoek Nederlands-Frans"
Hiligsmann, Philippe; Baelen, Mélanie; Leloup, Anne-Lore et al

Book published by KANTL (2008)

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See detailHergé dynamité. De Tintin à TNT en Amérique
Meesters, Gert ULg

in Art&Fact (2008), (27), 95-101

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See detailLe rumex à feuilles obtuses dans les systèmes herbagers : importance de la problématique, lutte chimique et méthodes alternatives
Stilmant, Didier ULg; Bodson, Bernard ULg; Knoden, D. et al

in Fourrages (2008), 192

Parmi les questions relatives à l'entretien des prairies, la lutte contre le rumex est une préoccupation fréquente, du fait de la vigueur et de la capacité d’adaptation considérables de la plante et de la ... [more ▼]

Parmi les questions relatives à l'entretien des prairies, la lutte contre le rumex est une préoccupation fréquente, du fait de la vigueur et de la capacité d’adaptation considérables de la plante et de la difficulté de la lutte contre cette adventice invasive dans des couverts complexes... Une enquête réalisée en région wallonne auprès d'exploitants agricoles et portant sur leurs pratiques de gestion et d'entretien des prairies montre l’importance de la pression exercée par Rumex obtusifolius L. qui représente un problème pour 40% d'entre eux ; la complémentation et l'épandage de lisier et de fumier de bovins sont corrélés avec la difficulté exprimée par les éleveurs. Une revue complète des traitements chimiques est effectuée selon la nature du couvert et l'âge de la prairie. Diverses méthodes de lutte alternatives sont également présentées (faux semis, type de travail du sol, gestion du pâturage…) ainsi que leur efficacité sur les jeunes plantules et sur les repousses de plantes de rumex. [less ▲]

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See detailQuand le lézard s'en mêle... Ethnographie de l'indexation collective de sites internet
Lejeune, Christophe ULg

in Sciences de la Société (2008), 75

We can not understand the peculiarity of website directories, compared to search engine, if we do not exhibit the ongoing elaboration done by human directories builders. In order to achieve this goal, the ... [more ▼]

We can not understand the peculiarity of website directories, compared to search engine, if we do not exhibit the ongoing elaboration done by human directories builders. In order to achieve this goal, the author propose an ethnography of procedures involved in the evaluation of websites candidates to be included in the Open Directory Project. The authors exposes how websites are challenged before being recorded in the database of the tool. The used criterion's lay on conventions about and the references format, and the content, and the design, and the accessibility. The paper describes how the editor's judgement is equipped by, and distributed with tools, yet-done (other's and himself) work, and external resources. As an inquirer, the editor's investigations are based either on contemporary indices and on historical traces. [less ▲]

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See detailMondialisation et cosmopolitisme
Pieret, Denis ULg

in Dissensus (2008), 1

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See detailLa place de l'analyse du condensat de l'air exhalé dans les maladies pulmonaires obstructives.
Renkin, C.; Corhay, Jean-Louis ULg; Louis, Renaud ULg

in Revue Médicale de Liège (2008), 63(4), 193-8

The number of publications on the analysis of the exhaled breath condensate (EBC) has increased considerably over the last five years. The EBC is a new, noninvasive and inexpensive technique which ... [more ▼]

The number of publications on the analysis of the exhaled breath condensate (EBC) has increased considerably over the last five years. The EBC is a new, noninvasive and inexpensive technique which requires a minimum of cooperation on behalf of the patient. The condensate obtained consists of more than 99.99% of water vapour, to which are added various substances which reflect the inflammatory status of the airways. It is now especially used to characterize the inflammatory state of chronic respiratory diseases such as asthma and COPD. This article describes the technique and reviews the main data from the current literature. [less ▲]

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See detailPredicting gene essentiality from expression patterns in Escherichia coli
Irrthum, Alexandre ULg; Wehenkel, Louis ULg

(2008)

Essential genes are genes whose loss of function causes lethal- ity. In the case of pathogen organisms, the identification of these genes is of considerable interest, as they provide targets for the ... [more ▼]

Essential genes are genes whose loss of function causes lethal- ity. In the case of pathogen organisms, the identification of these genes is of considerable interest, as they provide targets for the development of novel antibiotics. Computational analyses have revealed that the posi- tions of the encoded proteins in the protein-protein interaction network can help predict essentiality, but this type of data is not always avail- able. In this work, we investigate prediction of gene essentiality from expression data only, using a genome-wide compendium of expression patterns in the bacterium Escherichia coli, by using single decision trees and random forests. We first show that, based on the original expression measurements, it is possible to identify essential genes with good accu- racy. Next, we derive, for each gene, higher level features such as average, standard deviation and entropy of its expression pattern, as well as fea- tures related to the correlation of expression patterns between genes. We find that essentiality may actually be predicted based only on the two most relevant ones among these latter.We discuss the biological meaning of these observations. [less ▲]

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See detailComment j'explore...une pathologie pleurale?
Duysinx, Bernard ULg; Corhay, Jean-Louis ULg; Nguyen Dang, Delphine ULg et al

in Revue Médicale de Liège (2008), 63(10), 615-23

Pleural involvements are common and various respiratory diseases including inflammatory, infectious, occupational, or neoplastic pathological entities...Pleural thickening and pleurisy are usual ... [more ▼]

Pleural involvements are common and various respiratory diseases including inflammatory, infectious, occupational, or neoplastic pathological entities...Pleural thickening and pleurisy are usual radiological presentation. Etiological diagnosis imposes a vast and sometimes difficult exploration and it, especially since the conventional imaging by radiology, ultrasound, scanning and nuclear magnetic resonance has no specific diagnostic criteria for pleural malignancy. The metabolic imaging by positron emission tomography (PET) has been gradually positioned in the decision-making algorithm exploration of the pleural disease due to its excellent sensitivity in the diagnosis of malignant pleurisy (88.8%-100%). The analysis of chemistry, bacteriology and cytology pleural fluid makes a significant contribution to the diagnostic approach. However, although inescapable, thoracocentesis has a diagnostic sensibility not exceeding 62%. Moreover, the sensibility of the pleural blind needle biopsies does not exceed 51%. So, thoracoscopy, more invasive, is often justified to precise pleural disease with a diagnostic sensitivity greater than 95%. Finally, despite the diagnostic arsenal available, over 10% of pleurisies remain unknown etiology. [less ▲]

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