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See detailLa goutte
Leclercq, P.; Malaise, Michel ULg

in Revue Médicale de Liège (2004), 59(5), 274-280

In the presence of a clinical acute monoarthritis, a differential diagnosis has to be made between septic arthritis, gout and diffuse chondrocalcinosis. Gout comes from a purine nucleotide metabolism ... [more ▼]

In the presence of a clinical acute monoarthritis, a differential diagnosis has to be made between septic arthritis, gout and diffuse chondrocalcinosis. Gout comes from a purine nucleotide metabolism disorder leading to serum urate level elevation. This hyperuricemia can lead to the deposition of monosodium urate crystals in the joints, causing acute attacks. After long-term evolution, others tissues as the kidneys can be involved: it is chronic gout. The definite diagnosis is based on the presence of monosodium urate crystals in the joint fluid. The diagnosis of gout should prompt a search for associated medical conditions that may affect both urate levels and longevity. These include alcoholism, various nephropathies, myeloproliferative disorders, and hypertension. [less ▲]

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See detailFièvre méditerranéenne familiale
Leclercq, P.; Hermesse, A.; Malaise, Michel ULg

in Revue Médicale de Liège (2004), 59(5), 320-325

Familial Mediterranean Fever (FMF) is an hereditary disease that especially affects people living around the Mediterranean sea. It is characterized by recurring fever and abdominal pain, eventually ... [more ▼]

Familial Mediterranean Fever (FMF) is an hereditary disease that especially affects people living around the Mediterranean sea. It is characterized by recurring fever and abdominal pain, eventually associated with localised pleuritis, synovitis or skin inflammation. The most serious complication is amyloidosis, which can lead to terminal renal failure. The attacks and complications can be avoided by life long administration of colchicine. Two independent French and American teams discovered the gene responsible for the disease in 1997. It encodes for a protein named pyrin/marenostrin involved in the homeostasis the inflammatory mechanisms. The main mutations have been identified and are henceforth accessible for molecular screening. [less ▲]

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See detailLe medicament du mois. Etoricoxib (Arcoxia)
Leclercq, P.; Malaise, Michel ULg

in Revue Médicale de Liège (2004), 59(5), 345-349

Etoricoxib (Arcoxia) is a novel non steroidal anti-inflammatory drug (NSAID) that selectively inhibits the inducible form of cyclo-oxygenase (COX), COX-2. Etoricoxib has a higher COX-1/COX-2 selectivity ... [more ▼]

Etoricoxib (Arcoxia) is a novel non steroidal anti-inflammatory drug (NSAID) that selectively inhibits the inducible form of cyclo-oxygenase (COX), COX-2. Etoricoxib has a higher COX-1/COX-2 selectivity ratio than the other COX-2-selective NSAIDs as rofecoxib, valdecoxib or celecoxib. Tablets of 60, 90 and 120 mg are available. The recommended dosage of etoricoxib is 60 mg/day for osteoarthritis, 90 mg/day for rheumatoid arthritis and 120 mg/day for acute gouty arthritis. Etoricoxib's efficacy has been widely studied in comparative studies, showing the same efficacy as non-COX-2 selective NSAID, with fewer gastro-intestinal adverse effects. [less ▲]

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See detailMicroarray screening for target genes of the proto-oncogene PLAG1.
Voz, Marianne ULg; Mathys, Janick; Hensen, Karen et al

in Oncogene (2004), 23(1), 179-91

PLAG1 is a proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary glands and of lipoblastomas. As PLAG1 is a transcription factor, able to activate ... [more ▼]

PLAG1 is a proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary glands and of lipoblastomas. As PLAG1 is a transcription factor, able to activate transcription through the binding to the consensus sequence GRGGC(N)(6-8)GGG, its ectopic expression presumably results in the deregulation of target genes, leading to uncontrolled cell proliferation. The identification of PLAG1 target genes is therefore a crucial step in understanding the molecular mechanisms involved in PLAG1-induced tumorigenesis. To this end, we analysed the changes in gene expression caused by the conditional induction of PLAG1 expression in fetal kidney 293 cell lines. Using oligonucleotide microarray analyses of about 12 000 genes, we consistently identified 47 genes induced and 12 genes repressed by PLAG1. One of the largest classes identified as upregulated PLAG1 targets consists of growth factors such as the insulin-like growth factor II and the cytokine-like factor 1. The in silico search for PLAG1 consensus sequences in the promoter of the upregulated genes reveals that a large proportion of them harbor several copies of the PLAG1-binding motif, suggesting that they represent direct PLAG1 targets. Our approach was complemented by the comparison of the expression profiles of pleomorphic adenomas induced by PLAG1 versus normal salivary glands. Concordance between these two sets of experiments pinpointed 12 genes that were significantly and consistently upregulated in pleomorphic adenomas and in PLAG1-expressing cells, identifying them as putative PLAG1 targets in these tumors. [less ▲]

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See detailBalade géologique le long de l'Ourthe, de Liège à Comblain-au-Pont
Ek, Camille ULg; Barchy, Laurent ULg; Marion, Jean-Marc ULg et al

Article for general public (2004)

The regional governement of Wallonia (Région wallonne, DGARNE) is actually supporting (since 1990) the "New geological map of Wallonia" research program, updating the former edition accomplished between ... [more ▼]

The regional governement of Wallonia (Région wallonne, DGARNE) is actually supporting (since 1990) the "New geological map of Wallonia" research program, updating the former edition accomplished between 1890 and 1919. The Walloon Region wants to enrich it by explicative works aiming to reach a large public like families, young people, etc... and to link physical activities to natural discoveries, in the respect of environment and nature. [less ▲]

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See detailLe carcinome de Merkel.
Barile, Paola ULg; Leroy, Cécile ULg; Bolle, S. et al

in Journal Français d'Ophtalmologie (2004), 27(4), 432-6

Merkel cell carcinoma is a neuroendocrine tumor of the skin, originating from neuroendocrine cells. A case report of Merkel cell carcinoma, discovered in a 77-Year-old woman, was diagnosed and confirmed ... [more ▼]

Merkel cell carcinoma is a neuroendocrine tumor of the skin, originating from neuroendocrine cells. A case report of Merkel cell carcinoma, discovered in a 77-Year-old woman, was diagnosed and confirmed on a biopsy. Diagnostic and therapeutic orientations of this unusual but malignant tumor are described. [less ▲]

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See detailComment j'explore ... une grosse jambe rouge.
Goffin, Véronique ULg; Hermanns-Le, Trinh ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2004), 59(3), 155-7

A consultation motivated by an enlarged red leg is a common situation. The causes are multiple and the diagnosis primarily relies on case history and physical examination distinguishing inflammatory red ... [more ▼]

A consultation motivated by an enlarged red leg is a common situation. The causes are multiple and the diagnosis primarily relies on case history and physical examination distinguishing inflammatory red legs from erythemato-violaceous presentations. Additional diagnostic search cannot be described as a single standardized procedure. Each disease calls for specific and different paraclinical investigations. The most frequent cause is erysipelas or a thrombophlebitis. Some vascular malformations and some functional circulatory disturbances are also possible, as well as sequelae of panniculitis or borreliosis. [less ▲]

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See detailAcnés paroxystiques.
Flagothier, Caroline ULg; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2004), 59(4), 177-9

Contrasting with the chronic evolution of acne vulgar, other types of acne are characterized by paroxysmal outbreaks. They can be endogenous or exogenous in origin. Each of these two groups can be further ... [more ▼]

Contrasting with the chronic evolution of acne vulgar, other types of acne are characterized by paroxysmal outbreaks. They can be endogenous or exogenous in origin. Each of these two groups can be further divided into separate entities. [less ▲]

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See detailReactions paroxystiques du cuir chevelu.
Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2004), 59(4), 180-5

The scalp is a unique site of the human body that may exhibit some particular physiopathological reactions. A few manifestations are paroxysmal. The main ones are the acute pruritus of pediculosis, and ... [more ▼]

The scalp is a unique site of the human body that may exhibit some particular physiopathological reactions. A few manifestations are paroxysmal. The main ones are the acute pruritus of pediculosis, and the pruritus at onset of dandruff or seborrhoeic dermatitis. One must add the telogen effuvium after solar exposure or during the post-partum, and the anagen dystrophic alopecia following chemotherapy. Other paroxysmal events include acute canitia and alopecia areata. [less ▲]

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See detailLa révolution internet
Choffray, Jean-Marie ULg

in Bair J. et V. Henry (Ed.) Regards Croisés sur les Méthodes Quantitatives de Gestion (2004)

Les technologies internet constituent-elles une simple étape ou bien une profonde révolution dans l’évolution des savoirs et pratiques de management ? L’objet de cet article est de présenter le fruit de ... [more ▼]

Les technologies internet constituent-elles une simple étape ou bien une profonde révolution dans l’évolution des savoirs et pratiques de management ? L’objet de cet article est de présenter le fruit de plusieurs années d’observation et de réflexion sur le nouvel espace de liberté auquel conduit l’adoption généralisée d’internet. Après avoir évalué le degré de maturité de ce secteur au travers de la performance de quelques acteurs représentatifs, nous décrivons l’incidence de ces technologies sur des dimensions telles que l’information, l’éducation, le commerce, l’investissement et l’industrie. Enfin, nous évoquons quelques pistes de développement futur et les opportunités qui y sont associées. [less ▲]

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See detailCompe rendu d'une édition de textes choisis de Denys le Chartreux
Delfosse, Annick ULg

in Moyen Age (Le) (2004), 110(4), 719

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See detailOral vitamin C reduces the injury to skeletal muscle caused by compartment syndrome.
Kearns, S. R.; Daly, Adrian ULg; Sheehan, K. et al

in Journal of Bone & Joint Surgery, British Volume (2004), 86(6), 906-11

Compartment syndrome is a unique form of ischaemia of skeletal muscle which occurs despite patency of the large vessels. Decompression allows the influx of activated leucocytes which cause further injury ... [more ▼]

Compartment syndrome is a unique form of ischaemia of skeletal muscle which occurs despite patency of the large vessels. Decompression allows the influx of activated leucocytes which cause further injury. Vitamin C is a powerful antioxidant which concentrates preferentially in leucocytes and attenuates reperfusion-induced muscle injury. We have evaluated the use of pretreatment with oral vitamin C in the prevention of injury caused by compartment syndrome in a rat cremasteric muscle model. Acute and delayed effects of pretreatment with vitamin C were assessed at one and 24 hours after decompression of compartment syndrome. Muscle function was assessed electrophysiologically. Vascular, cellular and tissue inflammation was assessed by staining of intercellular adhesion molecule-1 (ICAM-1) and by determination of the activity of myeloperoxidase (MPO) in neutrophils and tissue oedema. Compartment syndrome impaired skeletal muscle function and increased the expression of ICAM-1, activity of MPO and muscle weight increased significantly. Pretreatment with vitamin C preserved muscle function and reduced the expression of ICAM-1, infiltration of the neutrophils and oedema. [less ▲]

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See detailLa génétique des migraines : des canaux ioniques aux polymorphismes de nucléotide ?
FUMAL, Arnaud ULg; Schoenen, Jean ULg

in Revue Médicale de Liège (2004), 59(6), 367-377

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See detailL'hôpital de jour: théatre d'avant garde d'une psychothérapie institutionnelle en mouvement
Thiels, Tineke; Triffaux, Jean-Marc ULg; Vos, Michel et al

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2004), 6

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See detailMotivation in the Gym: A Qualitative Approach
Cloes, Marc ULg

in Chin, M. K.; Hensley, L. D.; Cote, P. (Eds.) et al Global Perspectives in the Integration of Physical Activity, Sports, Dance, and Exercise Science in Physical Education: From Theory to Practice (2004)

Students’ motivation is a major concern of physical education teachers as well as it interest the others educators. Understanding of that complex variable increased during the last two decades. In the ... [more ▼]

Students’ motivation is a major concern of physical education teachers as well as it interest the others educators. Understanding of that complex variable increased during the last two decades. In the physical education domain, many studies were focused on isolated variables related to motivation and on their relationship with pupils’ behaviours. More recently, qualitative researches were conducted to enter in the class specificity and to integrate the complexity and diversity of the variables that influence students’ motivations. Combining questionnaires interviews and observation, some researchers have confirmed that student’s motivation depends on a package of dispositional as well as individual and collective situational factors. They pointed out also the determining role of the teacher in the development of a motivated class climate. This paper will describe a couple of qualitative studies designed to analyse students’ motivation and will underline their contribution in the understanding of the phenomena related to the development of motivation by students. Moreover, as teachers need research directly focused to their concerns, we must now provide them more support helping them to apply research data. The action research design is proposed as an appropriate approach in that way. The description of a pilot action research focused on the improvement of the students’ motivation in a secondary school level girls class will also proposed. The main results should provide the starting point of a reflective process about the strategies that teachers could plan on the gym. As it has been underlined above, the goal of the paper was to share useful information with practitioners and researchers and to encourage them to involve themselves in personal research on students’ motivation. [less ▲]

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See detailL'approcia neuropsichologico all'analisi delle sindromi dello svilupo associate all chromosoma X
Rondal, Jean-Adolphe ULg; Comblain, Annick ULg

in Giornale Italiano delle Disabilità (2004), 3

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See detailComparison between single-beat and multiple-beat methods for estimation of right ventricular contractility.
Lambermont, Bernard ULg; Segers, Patrick; Ghuysen, Alexandre ULg et al

in Critical Care Medicine (2004), 32(9), 1886-90

OBJECTIVE: It was investigated whether pharmacologically induced changes in right ventricular contractility can be detected by a so-called "single-beat" method that does not require preload reduction ... [more ▼]

OBJECTIVE: It was investigated whether pharmacologically induced changes in right ventricular contractility can be detected by a so-called "single-beat" method that does not require preload reduction. DESIGN: Prospective animal research. SETTING: Laboratory at a large university medical center. SUBJECTS: Eight anesthetized pigs. INTERVENTIONS: End-systolic elastance values obtained by a recently proposed single-beat method (Eessb) were compared with those obtained using the reference multiple-beat method (Eesmb). MEASUREMENTS AND MAIN RESULTS: Administration of dobutamine increased Eesmb from 1.6 +/- 0.3 to 3.8 +/- 0.5 mm Hg/mL (p =.001), whereas there was only a trend toward an increase in Eessb from 1.5 +/- 0.2 to 1.7 +/- 0.4 mm Hg/mL. Esmolol decreased Eesmb from 1.7 +/- 0.3 to 1.1 +/- 0.2 mm Hg/mL (p =.006), whereas there was only a trend for a decrease in Eessb from 1.5 +/- 0.2 to 1.3 +/- 0.1. CONCLUSIONS: The present method using single-beat estimation to assess right ventricular contractility does not work as expected, since it failed to detect either increases or decreases in right ventricular contractility induced by pharmacologic interventions. [less ▲]

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See detailBaseline study of perfluorochemicals in harbour porpoises (Phocoena phocoena) from Northern Europe
Van de Vijver, Kristin Inneke; Hoff, P. T.; Das, Krishna ULg et al

in Marine Pollution Bulletin (2004), 48(9-10), 992-997

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See detailRecension: "Les aspects juridiques de l'"outsourcing"
Kohl, Benoît ULg

in Revue de la Faculté de Droit de l'Université de Liège (2004)

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