Publications ORBi OA
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See detailAt the crossing of physics and Aercheology : the OSIRIS project
Renotte, Yvon ULg; Laboury, Dimitri ULg; Tilkens, Bernard et al

in Europhysics News (2004), 35/6

How physics can help aercheology, including a path to the parket

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See detailTraitement de l'osteoporose postmenopausique en 2004
Reginster, Jean-Yves ULg; Devogelaer, Jean-Pierre

in Revue Médicale de Liège (2004), 59(11), 633-47

Major improvements have been observed, during the last ten years, in the management of postmenopausal osteoporosis. The most significant benefits have been obtained through the availability of new ... [more ▼]

Major improvements have been observed, during the last ten years, in the management of postmenopausal osteoporosis. The most significant benefits have been obtained through the availability of new medications which have demonstrated their anti-fracture efficacy in the course of well conducted, scientifically sound studies. Due to the pharmacological properties of these new medications, treatment of osteoporosis can now be tailored to the needs of each and every single postmenopausal woman. Calcium supplementation (500 mg/day) should be offered to all post menopausal women unless dietary records show a sufficient intake. On the grounds of the high prevalence of low serum vitamin D levels in the ederly Belgian population, the systematic use of a calcium-vitamin D combination, after the age of 65 years, appears to be justified. Raloxifene is an interesting option for women with low mineral density or prevalent vertebral fractures. This molecule has demonstrated unequivocal anti-fracture efficacy at the level of the spine and is also caracterized by a beneficial effect on non-spinal fractures, in high risk women. Bisphosphonates (alendronate and risedronate) have shown the anti-fracture efficacy at the level of the axial and appendicular skeleton. The availability of a weekly formulation improves their compliance, notwithstanding the constrains related to the potential upper gastro-intestinal toxicity of these compounds. Bisphosphonates appear to be the first-line choice for patients with more severe osteoporosis and high risk to develop hip fractures. Teriparatide (1-34 Fragment of parathyroid hormone) is a new pharmacological option, oriented, mainly if not exclusively because of its parenteral administration and high cost, to patients with severe osteoporosis (low bone density and prevalent vertebral fracture(s). Strontium ranelate offers an anti-fracture efficacy at all skeleton sites and an oustanding overall tolerance and may play a main role in the future management of osteoporosis. [less ▲]

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See detailHow many women can benefit from a full intrapartum antibiotic prphylaxis for prevention of perinatal group B streptococcal disease?
MELIN, Pierrette ULg; Lorquet, Sophie; Rodriguez Cuns, Grisel et al

in American Society of Microbiology (Ed.) Program and Abstracts of the 44th Intersciences Conference on Antimicrobial Agents and Chemotherapy (2004, November)

Background: In Belgium as in many Western countries, GBS are still the leading cause of severe perinatal infections. Current guidelines for prevention recommend intrapartum antimicrobial prohylaxis (IAP ... [more ▼]

Background: In Belgium as in many Western countries, GBS are still the leading cause of severe perinatal infections. Current guidelines for prevention recommend intrapartum antimicrobial prohylaxis (IAP) administered promptly before delivery to pregnant women colonized with GBS. The risk of vertical GBS transmission to the newborn decreases as the duration of prophylaxis increases. The considered threshold for prophylaxis adequacy is the first dose administered at least 4 hours before delivery. Objective: To evaluate the proportion of pregnant women who could benefit from an adequate IAP for the prevention of GBS perinatal infections. Methods: Between June and October 2003, we recorded in two hospitals the elapse time between admission for labor and delivery. We assumed 5 hours represent a useful threshold to allow admission, revision of chart and administration of adequate IAP. The status of vaginal colonization with GBS was determined by CDC’s recommended culture method with Granada agar added. Results: Among 532 women, 27.3 % delivered within 5 hours after admission for labor. The colonization rate for GBS was 25.6 %. The distribution of elapse time between admission and delivery for GBS colonized pregnant women was not significantly different from non colonized women (p <= 1). Conclusions: 1) With the current prevention strategy, 27.3 % of these pregnant women would not have benefit from adequate prophylaxis 2) These results highlight the importance of an efficient organization to warranty prompt administration of IAP as soon as possible when mandatory. 3) If a rapid intrapartum screening test is used, no delay can be afforded “from ward to bench to bed”. [less ▲]

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See detailReal-Time PCR detection of group B streptococci from pregnant women's vaginal specimens at time of delivery: clinical evaluation
MELIN, Pierrette ULg; Rodriguez Cuns, Grisel; Lorquet, Sophie et al

in American Society of Microbiology (Ed.) Program and Abstracts of the 44th Intersciences Conference on Antimicrobial Agents and Chemotherapy (2004, November)

Guidelines for prevention recommend intrapartum antimicrobial prohylaxis (IAP) for pregnant women with a positive prenatal culture-based screening for GBS. To improve this strategy, a rapid screening ... [more ▼]

Guidelines for prevention recommend intrapartum antimicrobial prohylaxis (IAP) for pregnant women with a positive prenatal culture-based screening for GBS. To improve this strategy, a rapid screening performed at the onset of labor with the IDI-Strep BTM test (IDI), a real time PCR detection (Infectio Diagnostic), may be used. Objective: To evaluate the performance of the IDI to detect GBS from vaginal specimens collected at time of delivery. Methods: Intrapartum vaginal specimens from 923 pregnant women were tested to determine the status of GBS colonization, by CDC’s recommended culture method (including selective LIM broth) with a Granada agar (GR) added as well as by the IDI and the immunologic StrepB OIATM test (OIA), BioStar. The performance of the different methods was compared. Results: GBS were recovered from 16.8% and 23.6% specimens respectively on primary culture plates and overall. The colonization rate for GBS was 18.6 % by IDI and 15.7 % by OIA testing. The sensitivity of IDI for identifying vaginal colonization status at delivery was 92 % or 77.1 % when compared to GR primary cultures or to overall culture results, and for the OIA, it was respectively 65.1 or 52.1 %. The specificity was 99.1 % for IDI and 95.5 % for OIA. The turnaround time for obtaining results was less than one hour for both IDI and OIA. Conclusions: 1) Strep B-IDI test, performed on intrapartum vaginal specimens, yields relevant results rapidly enough to be used as an efficient diagnostic tool for the identification of GBS colonized women, in order to offer IAP really targeted to GBS carriers. 2) By comparison to the prenatal screening-based strategy, the high sensitivity and specificity of IDI would allow a reduction of useless IAP and of missed opportunities. 3) IDI testing might be implemented “in routine” in some hospitals for further clinical and practical evaluation. [less ▲]

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See detailExtreme catalysts from low-temperature environments
Hoyoux, A.; Blaise, Vinciane ULg; Collins, T. et al

in Journal of Bioscience & Bioengineering (2004), 98(5), 317-330

Cold-loving or psychrophilic organisms are widely distributed in nature as a large part of the earth's surface is at temperatures around 0 degrees C. To maintain metabolic rates and to prosper in cold ... [more ▼]

Cold-loving or psychrophilic organisms are widely distributed in nature as a large part of the earth's surface is at temperatures around 0 degrees C. To maintain metabolic rates and to prosper in cold environments, these extremophilic organisms have developed a vast array of adaptations. One main adaptive strategy developed in order to cope with the reduction of chemical reaction rates induced by low temperatures is the synthesis of cold-adapted or psychrophilic enzymes. These enzymes are characterized by a high catalytic activity at low temperatures associated with a low thermal stability. A study of protein adaptation strategies suggests that the high activity of psychrophilic enzymes could be achieved by the destabilization of the active site, allowing the catalytic center to be more flexible at low temperatures, whereas other protein regions may be destabilized or as rigid as their mesophilic counterparts. Due to these particular properties, psychrophilic enzymes offer a high potential not only for fundamental research but also for biotechnological applications. [less ▲]

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See detailDifferent patterns of insulin resistance in relatives of type 1 diabetic patients with retinopathy or nephropathy
Hadjadj, S.; Pean, F.; Pean, F. et al

in Diabetes Care (2004), 27(11), 2661-2668

OBJECTIVE- Insulin resistance may be a risk factor for diabetic microangiopathy, which may have a familial component. We carried out a family-based study to determine which components of the insulin ... [more ▼]

OBJECTIVE- Insulin resistance may be a risk factor for diabetic microangiopathy, which may have a familial component. We carried out a family-based study to determine which components of the insulin resistance syndrome are associated with diabetic retinopathy and nephropathy in type 1 diabetes. RESEARCH DESIGN AND METHODS- The Genesis France-Belgium Study is a multicenter binational study designed to investigate the genetic factors involved in the microvascular complications of type 1 diabetes using a family-based design. Probands were type 1 diabetic patients with diabetic retinopathy (classified as background, preproliferative, or proliferative) and possibly diabetic nephropathy (absent, incipient, established, or advanced). The insulin resistance score of their first-degree relatives was calculated according to their BMI and history of arterial hypertension, lipid disorders, and type 2 diabetes. RESULTS- The insulin resistance score of relatives was positively correlated with the albumin excretion rate (P = 0.0009) and fasting plasma glucose (P = 0.0003) and HbA(1c) (P < 0.0001) concentrations. This score was higher in the relatives of probands with than in those without diabetic nephropathy (P = 0.0370). Similarly, it was higher in relatives of subjects with proliferative diabetic retinopathy than in those of probands without, even after controlling for subjects with versus without diabetic nephropathy (P = 0.0379). However, the components of the insulin resistance score in relatives differed according to the severity of diabetic retinopathy or nephropathy in the probands. Obesity and history of arterial hypertension were most common in relatives of probands with proliferative diabetic retinopathy, whereas obesity and history of lipid disorders were most common in the relatives of probands with diabetic nephropathy. CONCLUSIONS- Familial insulin resistance segregates with diabetic complications: lipid disorders and obesity segregate with diabetic nephropathy, whereas arterial hypertension and obesity segregate with diabetic retinopathy. [less ▲]

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See detailHuman chorionic gonadotropin and growth factors at the embryonic-endometrial interface control leukemia inhibitory factor (LIF) and interleukin 6 (IL-6) secretion by human endometrial epithelium
PERRIER d'HAUTERIVE, Sophie ULg; Charlet, Jeanne de Chantal ULg; Berndt, Sarah ULg et al

in Human Reproduction (2004), 19(11), 2633-2643

BACKGROUND: The elucidation of the molecular mechanisms by which the embryo contributes to its implantation is an area of extensive research. The main objective of this study was to investigate the ... [more ▼]

BACKGROUND: The elucidation of the molecular mechanisms by which the embryo contributes to its implantation is an area of extensive research. The main objective of this study was to investigate the pattern of leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) secretion by human endometrial epithelium, and their regulation by human chorionic gonadotropin (hCG) and other growth factors present at the embryonic-endometrial interface. METHODS: Endometrial epithelial cells (EEC) were isolated from biopsies collected at both proliferative and secretory phases of fertile women. RESULTS: HCG (1-50 IU/ml) increased LIF secretion by EEC cultures derived from follicular phase (up to 285+/-75%) or from secretory phase (up to 212+/-16%). In contrast, hCG reduced IL-6 secretion by EEC in both phases. The hCG/LH receptor gene was transcribed by EEC as evidenced by RT-PCR. Insulin-like growth factors 1 and 2 increased LIF secretion by EEC. Transforming growth factor beta1 stimulated LIF and reduced IL-6 secretion. CONCLUSIONS: Through hCG, the blastocyst may be involved in the control of its implantation (via an increase of proimplantatory LIF) and tolerance (via an inhibition of proinflammatory IL-6). Other growth factors present at the embryonic-endometrial interface are also involved in the control of LIF and IL-6 endometrial secretion. [less ▲]

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See detailLumiracoxib is effective in the treatment of osteoarthritis of the knee: a 13 week, randomised, double blind study versus placebo and celecoxib
Tannenbaum, H.; Berenbaum, F.; Reginster, Jean-Yves ULg et al

in Annals of the Rheumatic Diseases (2004), 63(11), 1419-1426

Objectives: To compare the efficacy and safety of lumiracoxib with placebo and celecoxib for osteoarthritis (OA) in a 13 week, multicentre, randomised, double blind study. Methods: After a 327 day washout ... [more ▼]

Objectives: To compare the efficacy and safety of lumiracoxib with placebo and celecoxib for osteoarthritis (OA) in a 13 week, multicentre, randomised, double blind study. Methods: After a 327 day washout period for non-steroidal anti-inflammatory drugs, 1702 patients with knee OA were randomised to lumiracoxib 200 or 400 mg once daily (od), celecoxib 200 mg od, or placebo (2:2:2:1). A visual analogue scale (VAS) pain intensity greater than or equal to40 mm was required. Primary efficacy variables were OA pain intensity (VAS mm) in the target knee, patient's global assessment of disease activity (VAS mm), and WOMAC pain subscale and total scores at 13 weeks. OA pain intensity, patient's and physician's global assessment of disease activity, and WOMAC (total and all subscale scores) were analysed by visit as secondary variables. Results: Lumiracoxib showed significant improvements in all primary and secondary variables compared with placebo. Lumiracoxib 200 mg od and celecoxib 200 mg od achieved similar improvements in OA pain intensity and functional status. Lumiracoxib 400 mg od demonstrated better efficacy for OA pain intensity and patient's global assessment of disease activity at weeks 2, 4, and 8 and similar efficacy at week 13 compared with celecoxib 200 mg od. The incidence of adverse events (AEs), serious AEs, and discontinuations due to AEs was similar in each group. Conclusion: Lumiracoxib demonstrated significant improvement in OA pain intensity, patient's global assessment of disease activity, and the WOMAC pain subscale and total scores compared with placebo. Lumiracoxib was well tolerated in this study, with overall tolerability similar to that of placebo and celecoxib. [less ▲]

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See detailCaractérisation de la farnésyle pyrophosphate synthase de pucerons
Beliveau, Catherine; Vandermoten, Sophie ULg; Francis, Frédéric ULg et al

Poster (2004, November)

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See detailComment j'explore... un syndrome polyuropolydipsique insipide
Schleich, FLorence ULg; Krzesinski, Jean-Marie ULg; Legros, Jean-Jacques ULg

in Revue Médicale de Liège (2004), 59(11), 664-668

The finding of a polyuropolydispsic syndrome should prompt a complete biological investigation of its etiology. If polyuria can be a minor sign as in psychiatric disorder, it can also be the first ... [more ▼]

The finding of a polyuropolydispsic syndrome should prompt a complete biological investigation of its etiology. If polyuria can be a minor sign as in psychiatric disorder, it can also be the first manifestation of diabetes mellitus but also central diabetes insipidus, the latter linked to cerebral tumors, metastases in the hypothalamus, granulomatous disease, but also nephrogenic diabetes insipidus such as chronic renal disease or autoimmune disease. Intracellular dehydration is the major risk in case of a polyuropolydipsic syndrome. Prognosis depends on the capacity to maintain water balance through an intact thirst mechanism. After a brief review of the majority of causes of diabetes insipidus, we propose a diagnosis algorithm to easily make the diagnosis. [less ▲]

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See detailIntegrating cognitive and collective aspects of work in evaluating technology
Nyssen, Anne-Sophie ULg

in IEEE Transactions on Systems Man and Cybernetics Part A-Systems and Humans (2004), 34(6), 743-748

Ergonomic criteria are receiving increasing attention from designers but their applications do not ensure that technology matches the user's abilities, needs, and work constraints. In this paper, we used ... [more ▼]

Ergonomic criteria are receiving increasing attention from designers but their applications do not ensure that technology matches the user's abilities, needs, and work constraints. In this paper, we used two series of studies conducted in the healthcare system to illustrate how important work analysis is in evaluating new technology in order to identify critical dimensions of work and anticipate the impact of the devices on these dimensions: one looking at a new automatic drug device for anesthetists and one at a new robotic surgery system. Given the results, we developed a methodology for evaluation of new technology in complex systems. The aim is to insist to assess the impacts of technology on all the dimensions of work: technical, performance, cognitive, organizational, and economic. Which dimensions and criteria will be developed more in detail depends on the results of the work analysis. [less ▲]

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See detailA Machine Learning Approach to Improve Congestion Control over Wireless Computer Networks
Geurts, Pierre ULg; El Khayat, Ibtissam; Leduc, Guy ULg

(2004, November)

In this paper, we present the application of machine learning techniques to the improvement of the congestion control of TCP in wired/wireless networks. TCP is suboptimal in hybrid wired/wireless networks ... [more ▼]

In this paper, we present the application of machine learning techniques to the improvement of the congestion control of TCP in wired/wireless networks. TCP is suboptimal in hybrid wired/wireless networks because it reacts in the same way to losses due to congestion and losses due to link errors. We thus propose to use machine learning techniques to build automatically a loss classifier from a database obtained by simulations of random network topologies. Several machine learning algorithms are compared for this task and the best method for this application turns out to be decision tree boosting. It outperforms ad hoc classifiers proposed in the networking literature. [less ▲]

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See detailImage du mois. Fibrodysplasie musculaire de l'artère rénale.
Gach, Olivier ULg; Pierard, Luc ULg; Legrand, Victor ULg

in Revue Médicale de Liège (2004), 59(11), 624-5

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See detailLa nación en los tiempos de la globalización: algunas tensiones en el discurso zapatista
Vanden Berghe, Kristine ULg

in Maihold, Günther (Ed.) Las modernidades de México. Espacios, procesos, trayectorias (2004, November)

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See detailDetermination of TGF-β1 plasma levels. Authors' reply
Barthelemy, Nicole ULg; De Jaeger, Katrien; SEPPENWOOLDE, Yvette et al

in International Journal of Radiation, Oncology, Biology, Physics (2004), 60(4), 1339

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See detailThe Articulation of “I”, “We” and the “Person”. Elements for an Anthropological Approach within Western and Islamic Contexts
Nachi, Mohamed ULg

in Dupret, Baudouin (Ed.) Standing Trial. Law and the Person in the Modern Middle East (2004, November)

Comment les éléments constitutifs de l'identité personnelle orientent-ils les jugements des individus, leur sens moral et leur perception du juste.

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See detailAre spatial memories strengthened in the human hippocampus during slow wave sleep?
Peigneux, Philippe ULg; Laureys, Steven ULg; Fuchs, Sonia et al

in Neuron (2004), 44(3), 535-545

In rats, the firing sequences observed in hippocampal ensembles during spatial learning are replayed during subsequent sleep, suggesting a role for posttraining sleep periods in the offline processing of ... [more ▼]

In rats, the firing sequences observed in hippocampal ensembles during spatial learning are replayed during subsequent sleep, suggesting a role for posttraining sleep periods in the offline processing of spatial memories. Here, using regional cerebral blood flow measurements, we show that, in humans, hippocampal areas that are activated during route learning in a virtual town are likewise activated during subsequent slow wave sleep. Most importantly, we found that the amount of hippocampal activity expressed during slow wave sleep positively correlates with the improvement of performance in route retrieval on the next day. These findings suggest that learning-dependent modulation in hippocampal activity during human sleep reflects the offline processing of recent episodic and spatial memory traces, which eventually leads to the plastic changes underlying the subsequent improvement in performance. [less ▲]

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See detailLa liberté de la presse a du plomb dans l'aile…
Durand, Pascal ULg

Article for general public (2004)

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See detailVers une analyse de la littérature francophone sur l’intervention en sport
Cloes, Marc ULg; Lenzen, Benoit; Trudel, Pierre

Poster (2004, October 23)

Les auteurs proposent une première analyse de la littérature francophone centrée sur la 'science du coaching'. Il s'agit d'une approche multidimensionnelle permettant d'identifier les principales ... [more ▼]

Les auteurs proposent une première analyse de la littérature francophone centrée sur la 'science du coaching'. Il s'agit d'une approche multidimensionnelle permettant d'identifier les principales caractéristiques des études publiées dans ce domaine de recherche en plein développement. [less ▲]

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See detailAnalyse de l'activité physique et sportive. Constats et réflexions
Cloes, Marc ULg

Conference given outside the academic context (2004)

Cet exposé vise à présenter les axes de recherche sur l'Interveniton en sport, suivis au sein du Service Intervention et Gestion en Activités physiques et sportives de l'Université de Liège.

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