Stromelysin-3 expression promotes tumor take in nude mice

in Journal of Clinical Investigation (1996), 97

Stromelysin-3 (ST3) is a matrix metalloproteinase expressed in human carcinomas in ways suggesting that it may play a role in tumor progression. To test this possibility, we have performed gene transfer ... [more ▼]

Stromelysin-3 (ST3) is a matrix metalloproteinase expressed in human carcinomas in ways suggesting that it may play a role in tumor progression. To test this possibility, we have performed gene transfer experiments using both anti-sense and sense ST3 expression vectors, and malignant cells either expressing (NIH 3T3 fibroblasts) or not (MCF7 epithelial cells) endogenous ST3. We have compared the ability of parental and transfected cells to cause subcutaneous tumor development in nude mice. 3T3 cells expressing anti-sense ST3 RNA showed reduced tumorigenicity, and MCF7 cells expressing mouse or human ST3 were associated with reduced tumor-free period leading to a significant increased tumor incidence(P<10(-4)). However, once established, the ST3 expressing tumors did not grow faster than those obtained with the parental MCF7 cell line. In addition, tumors obtained after sub-cutaneous injection of ST3-expressing or nonexpressing cells did not exhibit obvious histological differences, and careful examination did not reveal any local invasive tissue areas nor systemic metastases. These in vivo observations were in agreement with those obtained in vitro showing that ST3 expression did not modify proliferative nor invasive properties of transfected cells. Altogether, these results indicate that ST3 expression promotes tumor take in nude mice, presumably by favoring cancer cell survival in a tissue environment initially not permissive for tumor growth. These findings represent the first experimental evidence showing that ST3 can modulate cancer progression. [less ▲]

Una Cabeza Bien Hecha O Una Cabeza Repleta ?

in Perspectivas (1996), XXVI(1),

Autologous stem cell transplantations in elderly AML patients

in Trends in Onco-Hematology (1996), 4(2), 28-29

Actualités thérapeutiques dans la thrombocytémie essentielle

in Médecine et Hygiène (1996), 54

Essential thrombocythemia is a myeloproliferative disorder affecting megakaryocyte and is characterized by frequent thrombotic or hemorrhagic complications. In young patients, the optimal management of ... [more ▼]

Essential thrombocythemia is a myeloproliferative disorder affecting megakaryocyte and is characterized by frequent thrombotic or hemorrhagic complications. In young patients, the optimal management of thrombocythaemia is controversial. Since th relationship of thrombosis and hemorrhage to platelet counts is not demonstrated, ther is no clear inidcation for using drugs capable of lowering platelet counts in young asymptomatic subjects. However, treatment should be offered to patients with a definite high risk of major or life-threatening hemostatic complications. The present paper reviews the incidence and risk factors for thrombotic complications and the use of medications inhibiting platelet production. [less ▲]

Phase ratio estimations from true color images

(1996)

Clinical PET in Oncology

Book published by GE Medical Systems (1996)

Tests au sol du télescope spatial XMM

in SupOptique Avenir 1996 page 14-16. (1996)

Comparaisons calculs-essais pour l'éprouvette cylindrique

Report (1996)

In this first application of the machining simulation tool prototype, great difficulties were encountered in the interpretaion of the physical test. In fact, parasitic deformations occured, with a three ... [more ▼]

In this first application of the machining simulation tool prototype, great difficulties were encountered in the interpretaion of the physical test. In fact, parasitic deformations occured, with a three-lobed form. This implied the necessity of filtering the experimental data and a physical interpretation of the undue deformation. A theoretical study is performed, leading to the result that this phenomenon is due to the combined effect of the clearance of the clamping jaws and the pre-stress of the dead center. [less ▲]

Comparaisons calculs-essais pour le palier de suspension J64

Report (1996)

This report is devoted to the J64 suspension bearing benchmark. Unfortunately, the actual machining led to considerable vibrations, rendering any comparison impossible.

Is Counter-Discursive Criticism Obsolescent? Intertextuality in Caryl Phillips's Higher Ground

in Maes-Jelinek, Hena; Collier, Gordon; Davis, Geoffrey V. (Eds.) A Talent(ed) Digger: Creations, Cameos, and Essays in Honour of Anna Rutherford (1996)