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See detailLe medicament du mois. Vildagliptine (Galvus) et combinaison fixe vildagliptine-metformine (Eucreas) dans le traitement du diabete de type 2.
Scheen, André ULg; Paquot, Nicolas ULg

in Revue Médicale de Liège (2009), 64(3), 161-7

Vildagliptin (Galvus) is a selective inhibitor of dipeptidylpeptidase-4, an enzyme involved in the metabolism of glucagon-like peptide-1 (GLP-1) secreted by L cells of the intestine. It potentiates the ... [more ▼]

Vildagliptin (Galvus) is a selective inhibitor of dipeptidylpeptidase-4, an enzyme involved in the metabolism of glucagon-like peptide-1 (GLP-1) secreted by L cells of the intestine. It potentiates the insulin secretory response (incretin effect) by enhancing the endogenous post-prandial response of GLP-1 (incretin enhancer) in a glucose-dependent manner. Vildagliptin is indicated in the treatment of type 2 diabetes. It improves blood glucose control (HbA1c) in patients treated by diet alone, metformin, sulfonylurea, glitazone or insulin. In patients not well controlled with metformin alone, the addition of vildagliptin is as effective in reducing HbA1c as the coadministration of glimepiride or pioglitazone. Tolerance of vildagliptin is excellent, with no weight gain and no hypoglycaemic episodes. Treatment is simple, with two doses of 50 mg per day, without need of titration or home blood glucose monitoring. In Belgium, vildagliptin is currently reimbursed for the treatment of type 2 diabetes after diet failure and monotherapy with metformin. Therapy can be administered separately or by using a fixed combination vildagliptin-metformin (Eucreas), which should improve drug compliance. [less ▲]

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See detailSustaining durable rural development through good practice models
Paveliuc Olariu, Codrin ULg

in Lucrări Ştiinţifice, Universitatea de Ştiinţe Agricole Şi Medicină Veterinară a Banatului, Timisoara, Seria I, Management Agricol (2009), 11(1), 225-232

Rural Economy and Strategic Management are expected to support durable rural developmentin reducing the gap between the growth that major urban centres had over the last years and that of small rural ... [more ▼]

Rural Economy and Strategic Management are expected to support durable rural developmentin reducing the gap between the growth that major urban centres had over the last years and that of small rural comunities. In particular, Rural Development and Strategic Consultancy provide access to high quality information and to appropiate protocols. The present paper aims to present the importance of strategic planning in durable rural development and, also, the role of a good practice model in the development of a rural community. The good practice model presented here was created as an experimental model for a middle-sized rural village based on statistical data provided by the National Statistics Institute. [less ▲]

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See detailFunctional analysis of yeast bcs1 mutants highlights the role of Bcs1p-specific amino acids in the AAA domain.
Nouet, Cécile ULg; Truan, Gilles; Mathieu, Lise et al

in Journal of Molecular Biology (2009), 388(2), 252-61

The mitochondrial protein Bcs1p is conserved from Saccharomyces cerevisiae to humans and its C-terminal region exhibits an AAA (ATPases associated with diverse cellular activities) domain. The absence of ... [more ▼]

The mitochondrial protein Bcs1p is conserved from Saccharomyces cerevisiae to humans and its C-terminal region exhibits an AAA (ATPases associated with diverse cellular activities) domain. The absence of the yeast Bcs1p leads to an assembly defect of the iron-sulfur protein (ISP) subunit within the mitochondrial respiratory complex III, whereas human point mutations located all along the protein cause various pathologies. We have performed a structure-function analysis of the yeast Bcs1p by randomly generating a collection of respiratory-deficient point mutants. We showed that most mutations are in the C-terminal region of Bcs1p and have localized them on a theoretical three-dimensional model based on the structure of several AAA proteins. The mutations can be grouped into classes according to their respiratory competence and their location on the three-dimensional model. We have further characterized five mutants, each substituting an amino acid conserved in yeast and mammalian Bcs1 proteins but not in other AAA proteins. The effects on respiratory complex assembly and Bcs1p accumulation were analyzed. Intragenic and extragenic compensatory mutations able to restore complex III assembly to the mutants affecting the AAA domain were isolated. Our results bring new insights into the role of specific residues in critical regions that are also conserved in the human Bcs1p. We show that (1) residues located at the junction between the Bcs1p-specific and the AAA domains are important for the activity and stability of the protein and (2) the residue F342 is important for interactions with other partners or substrate proteins. [less ▲]

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See detailRural – urban interactions. Influences on the rural development process in the North-East Region of Romania
Paveliuc Olariu, Codrin ULg

in Scientific Papers Management, Economic Engineering in Agriculture and Rural Development (2009), 9(3), 157-160

This paper aims to present the interactions that occur between urban and rural, realizing a strict separation of these two areas, their populations and their activities here. This thing is being reflected ... [more ▼]

This paper aims to present the interactions that occur between urban and rural, realizing a strict separation of these two areas, their populations and their activities here. This thing is being reflected in the division of policies on spatial and sectorial criteria, urban planners usually concentrating on the importance of urban centers as commerce and transportation nods in the regional policy giving little attention to agricultural or rural-led development. It is based on statistical data provided by the Ministry of Agriculture, Forests and Rural Development and by the National Statistics Institute and on direct observation executed in the North – East region of Romania. The data has been processed into the following indicators: aging indicator, average number of rural inhabitants, active occupied population, infant mortality, the average index of poverty and others. This paper represents an overview of how the strategies of urban and rural are intertwined. It ends with some recommendations on how the planners and decision makers can take these issues into consideration. [less ▲]

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See detailRodents within the Centre for Thai National Reference Collections (CTNRC), Past, Present and Future
Waengsothorn, Surachit; Kenthao, Anan; Latinne, Alice ULg et al

in Kasetsart Journal. Natural Sciences (2009), 43

The Centre for Thai National Reference Collections (CTNRC) was officially established in 1965, but animal collections in Thailand had been continuously conducted long before this time. This paper gives an ... [more ▼]

The Centre for Thai National Reference Collections (CTNRC) was officially established in 1965, but animal collections in Thailand had been continuously conducted long before this time. This paper gives an historical review of the main steps leading to the constitution of the current collections under the administration of TISTR, with a focus on the rodent collection, which represents about one fifth of the whole mammal specimens. An inventory of the species and genera represented is given. Statistics representing the sampling effort in the different Thai provinces are given. The paper concludes with considerations on the current and future needs and the means necessary to develop and support the efforts of the CTNRC. [less ▲]

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See detailConceptual model for the realization of SWOT analysis to elaborate local development strategies
Paveliuc Olariu, Codrin ULg

in Agronomy Series of Scientific Research = Lucrari Stiintifice Seria Agronomie (2009), 52(2), 532-537

This paper aims to present the ways of making SWOT analysis using quantitative and qualitative models and establishing the optimal development strategies of rural settlements in the North – East region of ... [more ▼]

This paper aims to present the ways of making SWOT analysis using quantitative and qualitative models and establishing the optimal development strategies of rural settlements in the North – East region of Romania, previously used to establish strategies within organizations. This represents an adaptation of this approach to another area of activity. Stratification criteria were established for the general domains at the level of all rural settlements in this development region (trade and catering, agriculture, living conditions, rural infrastructure, access to basic services, public order and safety, constructions, administration and civil society and others) that were then classified, according to actual needs of local communities, into areas of expertise. This conceptual model can be applied to the entire North – East development region, being built on data collected from 6 different counties (Botosani, Iasi, Vaslui, Bacau, Neamt, Suceava).Based on the stratification criteria of the domains encountered in the rural villages of the North – East region, a division and classification of the durable rural development strategies of local communities has been realized according to the opportunities and threats presented by their external environment and by their strengths and weaknesses. By virtue of these characteristics determined by the quantitative and qualitative models of the SWOT analysis, we will have four types of strategies that can be used. It has been discovered that the majority of local communities’ present characteristics that do not allow the application of only one type of strategy, but that can generate various combinations between the four types of achieving them. It results then a customization of the conceptual model of realizing the local development strategies according to local conditions. However there is a preponderance of one of the four types of strategies (SO, ST, WO, WT). [less ▲]

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See detailGénération, cénacle, mouvance : essai de sociologie quantitative des Jeunes-France
Dozo, Björn-Olav ULg; Glinoer, Anthony

in Les Cahiers du XIXe siècle (2009), III-IV

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See detailInhibitory control of memory in normal ageing: Dissociation between impaired intentional and preserved unintentional processes.
Collette, Fabienne ULg; Germain, Sophie ULg; Hogge, Michaël et al

in Memory (2009), 17(1), 104-122

The aim of this study was to compare the performance of elderly and young participants on a series of memory tasks involving either intentional or unintentional inhibitory control of memory content ... [more ▼]

The aim of this study was to compare the performance of elderly and young participants on a series of memory tasks involving either intentional or unintentional inhibitory control of memory content. Intentional inhibition processes in working and episodic memory were explored with directed forgetting tasks and in semantic memory with the Hayling task. Unintentional inhibitory processes in working memory, long-term memory, and semantic memory were explored with an interference resolution task, the retrieval practice paradigm, and the flanker task, respectively. The results indicate that elderly participants' performance on the two directed forgetting tasks and the Hayling task is lower than that of young ones, and that this impairment is not related to their initial memory capacity. This suggests that there is a specific dysfunction affecting intentional inhibitory control of memory contents in normal ageing. [less ▲]

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See detailOn the demanding necessity of properly evaluating renal graft function in clinical trials.
Maillard, Nicolas; Alamartine, Eric; Berthoux, Francois et al

in Transplant International (2009), 22(2), 247-8

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See detailPhysical characteristics of the back are not predictive of low back pain in healthy workers : a prospective study
Van Nieuwenhuyse, An; Crombez, Geert; Burdorf, Alex et al

in BMC Musculoskeletal Disorders (2009), 10(2), 1-9

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See detailSevere cardiac phenotype of Berardinelli-Seip congenital lipodystrophy in an infant with homozygous E189X BSCL2 mutation
Friguls, B.; Coroleu, W.; Del Alcazar, R. et al

in European Journal of Medical Genetics (2009), 52(1), 14-16

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See detailInternet et la reconfiguration de l’espace public tunisien : le rôle de la diaspora
Lecomte, Romain ULg

in tic&société (2009), 3(1-2),

Using a sociological approach, we show how Tunisians of the diaspora take advantage of Internet to keep themselves involved and informed and to denounce what they consider as unjust in their native ... [more ▼]

Using a sociological approach, we show how Tunisians of the diaspora take advantage of Internet to keep themselves involved and informed and to denounce what they consider as unjust in their native country. We describe the style of critical speech preferred by these activist Internet users and the type of public sphere they claim. We study the activist paths of some of them and analyse their relationships with Internet users living in Tunisia. While they are initially less likely to openly denounce (use of indirect criticism) the authoritarian regime, we illustrate how these Internet users in Tunisia come to play an increasingly important role in this new space of contestation. [less ▲]

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See detailLas relaciones polaco-ucranianas durante las transformaciones del sistema europeo en la década de los años noventa
Natorski, Michal ULg

in Flores-Juberías, Carlos (Ed.) España y la Europa Oriental: tan lejos, tan cerca (Actas del V Encuentro Español de Estudios sobre la Europa Oriental) (2009)

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See detailXRF major and trace element determination in Fe-Ti oxide minerals
Duchesne, Jean-Clair ULg; Bologne, Guy

in Geologica Belgica (2009), 12(3-4), 205-212

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See detailL’impact du miellat de puceron au niveau des relations tritrophiques entre les plantes-hôtes, les insectes ravageurs et leurs ennemis naturels
Leroy, Pascal ULg; Capella, Quentin; Haubruge, Eric ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2009), 13(2), 325-334

Tritrophic relations between plants, phytophagous insects and beneficials are based on the presence of chemical cues in the environment. In this context, honeydew (the aphid excretory product), rich in ... [more ▼]

Tritrophic relations between plants, phytophagous insects and beneficials are based on the presence of chemical cues in the environment. In this context, honeydew (the aphid excretory product), rich in sugars and amino-acids, constitutes a nutritional resource for beneficials but also acts as a volatile and a contact kairomone. On one hand, honeydew volatile chemicals cues guide beneficials to a food source, hosts or preys but also stimulate particular behaviors : searching, preys/hosts locations and attacks. On the other hand, a contact with honeydew induces the oviposition especially for syrphids (Episyrphus balteatus, …). The use of an artificial honeydew could be a way for enhancing the biological control efficiency in fields by increasing the number of beneficials but also the predation and parasitic rates. [less ▲]

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See detailEnfants négligés : ils naissent, ils vivent, mais surtout ils survivent
Bednarek, Stéphanie ULg; Absil, Gaëtan ULg; Vandoorne, Chantal ULg et al

in Presse Médicale (2009), 38

Child neglect leads to numerous and serious consequences. The physical and neurophysiological development can be altered by the lack of stimulation or via a chronic stress which increases the production ... [more ▼]

Child neglect leads to numerous and serious consequences. The physical and neurophysiological development can be altered by the lack of stimulation or via a chronic stress which increases the production of cortisol. Gradually, psychomotor and cognitive deficits can appear. The emotions can be deeply touched and cause dysfunctional social relationship, ranging from withdrawal to aggressiveness. Primary care health practitioners have a role to play in the screening of risk situations and long term follow-up of the families. The interventions should ideally begin early, be participatory and based on an enhancement of the parent-child relationship. [less ▲]

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See detailEnhanced ocean carbon storage from anaerobic alkalinity generation in coastal sediments
Thomas, H.; Schiettecatte, L.-S.; Suykens, Kim ULg et al

in Biogeosciences (2009), 6

The coastal ocean is a crucial link between land, the open ocean and the atmosphere. The shallowness of the water column permits close interactions between the sedimentary, aquatic and atmospheric ... [more ▼]

The coastal ocean is a crucial link between land, the open ocean and the atmosphere. The shallowness of the water column permits close interactions between the sedimentary, aquatic and atmospheric compartments, which otherwise are decoupled at long time scales ( =1000 yr) in the open oceans. Despite the prominent role of the coastal oceans in absorbing atmospheric CO2 and transferring it into the deep oceans via the continental shelf pump, the underlying mechanisms remain only partly understood. Evaluating observations from the North Sea, a NW European shelf sea, we provide evidence that anaerobic degradation of organic matter, fuelled from land and ocean, generates total alkalinity (AT) and increases the CO2 buffer capacity of seawater. At both the basin wide and annual scales anaerobic AT generation in the North Sea’s tidal mud flat area irreversibly facilitates 7–10%, or taking into consideration benthic denitrification in the North Sea, 20–25% of the North Sea’s overall CO2 uptake. At the global scale, anaerobic AT generation could be accountable for as much as 60% of the uptake of CO2 in shelf and marginal seas, making this process, the anaerobic pump, a key player in the biological carbon pump. Under future high CO2 conditions oceanic CO2 storage via the anaerobic pump may even gain further relevance because of stimulated ocean productivity. [less ▲]

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