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See detailLe syndrome de Parsonage et Turner
Kaux, Jean-François ULg; Wang, François ULg

Conference (2004, November 02)

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See detailThe photospheric abundances of active binaries. III. Abundance peculiarities at high activity levels
Morel, Thierry ULg; Micela, G.; Favata, F. et al

in Astronomy and Astrophysics (2004), 426

We report the determination from high-resolution spectra of the atmospheric parameters and abundances of 13 chemical species (among which lithium) in 8 single-lined active binaries. These data are ... [more ▼]

We report the determination from high-resolution spectra of the atmospheric parameters and abundances of 13 chemical species (among which lithium) in 8 single-lined active binaries. These data are combined with our previous results for 6 other RS CVn systems to examine a possible relationship between the photospheric abundance patterns and the stellar activity level. The stars analyzed are generally found to exhibit peculiar abundance ratios compared to inactive, Galactic disk stars of similar metallicities. We argue that this behaviour is unlikely to be an artefact of errors in the determination of the atmospheric parameters or non-standard mixing processes along the red giant branch, but diagnoses instead the combined action of various physical processes related to activity. The most promising candidates are cool spot groups covering a very substantial fraction of the stellar photosphere or NLTE effects arising from nonthermal excitation. However, we cannot exclude the possibility that more general shortcomings in our understanding of K-type stars (e.g. inadequacies in the atmospheric models) also play a significant role. Lastly, we call attention to the unreliability of the (V-R) and (V-I) colour indices as temperature indicators in chromospherically active stars. Based on observations collected at the European Southern Observatory, Chile (Proposals 64.L-0249 and 071.D-0260). Table A.1 is only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/426/1007 [less ▲]

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See detailPolarization properties of broad absorption line QSOs: New statistical clues
Lamy, H.; Hutsemekers, Damien ULg

in Astronomy and Astrophysics (2004), 427

We report the results of several statistical tests performed on a large sample of 139 broad absorption line (BAL) QSOs with good quality optical spectra and/or optical polarization data. Correlations ... [more ▼]

We report the results of several statistical tests performed on a large sample of 139 broad absorption line (BAL) QSOs with good quality optical spectra and/or optical polarization data. Correlations between ten optical indices and the polarization degree p[SUB]0[/SUB] are systematically searched for. We find six significant non-trivial correlations. In order to identify the most important correlations, we perform a principal component analysis with a sample of 30 BAL QSOs and eight quantities (including p[SUB]0[/SUB]). Most of the variance (Ë 57%) in the data is contained in two principal components called PC1 and PC2. PC1 is mainly dominated by the correlation between the balnicity index BI and the strength of the Fe II emission; it may be driven by the accretion rate of matter onto the central compact object. The variance in PC2 is essentially due to the anti-correlation between p[SUB]0[/SUB] and the detachment index DI, indicating that BAL QSOs with P Cygni profiles (DIâ ª) are usually more polarized than those objects with C IV absorption troughs well detached from the corresponding emission lines (DIâ «). We show that PC2 may be related to the orientation of the BAL QSOs with respect to the line of sight. We also present new spectropolarimetric observations of six BAL QSOs. By adding spectropolarimetric data from the literature, we build a sample of 21 BAL QSOs for which we define four spectropolarimetric indices describing the polarization properties of the absorption and emission lines. We find that the polarization of the C III]] emission line is systematically higher than the polarization of the C IV emission line, and that the highest polarization in the troughs is correlated to the balnicity index. Another important result emerging from the statistical tests performed on this spectropolarimetric sample is a possible anti-correlation between the detachment index and a quantity SI which measures the ratio of the depths of the C IV absorption in the polarized flux and in the total flux. This correlation indicates that in BAL QSOs with P cygni profiles, the BAL troughs in the polarized flux are nearly as deep as in the total flux while, in BAL QSOs with detached absorptions, the BAL troughs in the polarized flux are much weaker than in the total flux. We show that our main results may be explained in the framework of a ``two-component'' wind model which is a natural extension of the classical wind-from-disk models. In this model, the broad absorption occurs in a dense equatorial wind emerging from the accretion disk, while scattering and polarization mainly take place in a polar region. The orientation relative to the observer drives the correlations p[SUB]0[/SUB] - DI and DI - SI. While most of our observations can be explained within this framework, there are also several indications that other polarization mechanisms, and more particularly resonance scattering, may also be at work. Based on observations collected at the European Southern Observatory (ESO, La Silla). Table 1 is only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http: / / cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/427/107 [less ▲]

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See detailL'astronomie dans le monde
Manfroid, Jean ULg

Article for general public (2004)

EF Eridani; Du sucre dans l'espace; Miras à la baisse; Eau et méthane sur Mars; Toutatis à  l'ESO; SMART-1; Pollution globale; L'univers en 3D : symposium Gaia à Paris; Découverte du plus grand champ de ... [more ▼]

EF Eridani; Du sucre dans l'espace; Miras à la baisse; Eau et méthane sur Mars; Toutatis à  l'ESO; SMART-1; Pollution globale; L'univers en 3D : symposium Gaia à Paris; Découverte du plus grand champ de cratères de météorites sur Terre; Cratère mystérieux; Minimum solaire [less ▲]

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See detailBorges traductor: refracciones y tapices de Flandes
Willson, Patricia ULg

Article for general public (2004)

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See detailLong-term outcome of patients with acromegaly and congestive heart failure
Bihan, Hélène; Espinosa, Consuelo; Valdes Socin, Hernan Gonzalo ULg et al

in Journal of Clinical Endocrinology and Metabolism (2004), 89(11), 5308-5313

Cardiovascular complications are a major cause of morbidity and mortality in patients with acromegaly. Normalization of GH secretion is associated with an improvement in structural and functional cardiac ... [more ▼]

Cardiovascular complications are a major cause of morbidity and mortality in patients with acromegaly. Normalization of GH secretion is associated with an improvement in structural and functional cardiac abnormalities. However, the long-term cardiac effects of treatment for acromegaly have not been studied in patients who have already developed chronic congestive heart failure (CHF). We reviewed the charts of 330 consecutive patients with acromegaly treated in two French and Belgian centers since 1985. Ten patients with both acromegaly and CHF (eight men, two women, mean age 49.7 yr) were studied retrospectively. One of them was excluded because CHF was due to severe aortic stenosis. CHF ( New York Heart Association stages III-IV and echocardiography showing dilated hypokinetic cardiomyopathy with left ventricular systolic dysfunction and a left ventricular ejection fraction less than 45%) was diagnosed before, concomitantly, or after acromegaly in, respectively, two, five, and two patients. Three patients were referred with terminal heart failure requiring transplantation. One patient had transient CHF associated with a hypertensive crisis. The other eight patients had symptomatic chronic CHF. Control of GH hypersecretion failed, totally or partially, in three patients: one had a long-term survival, and the two others died at 1 and 5 yr. Good GH control was achieved in five patients: four of these are still alive 2-16 yr after diagnosis of CHF, their clinical status is stable or improved, and their quality of life is good. Overall, the 1- and 5-yr mortality ( or transplantation) rates for patients with chronic symptomatic CHF were 25% ( 2 of 8 patients) and 37.5% ( 3 of 8 patients), respectively. In conclusion, less than 3% of acromegalic patients developed CHF in this study. Although effective treatment of acromegaly improved short-term cardiovascular status, its impact on long-term survival is questionable. [less ▲]

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See detailVers une proposition de mode de détermination de la distance minimale à respecter entre les bâtiments d'élevage et les habitations.
Nicolas, Jacques ULg; Otte, Benoît

Report (2004)

Le cahier des charges de cette petite étude prévoyait trois étapes: - précision de la faisabilité des lignes-guides pour la Wallonie, - comparaison des distances calculées par les lignes-guides aux zones ... [more ▼]

Le cahier des charges de cette petite étude prévoyait trois étapes: - précision de la faisabilité des lignes-guides pour la Wallonie, - comparaison des distances calculées par les lignes-guides aux zones de nuisances olfactive évaluées par d'autres méthodes, - proposition pour une réglementation ou un guide de bonnes pratiques applicables en Wallonie. Le groupe de recherche d'Arlon a décidé de tester la faisabilité des lignes-guides existant dans d'autres pays ou régions sur base d'études de cas concrets, avec visites de terrain. En simulant, pour chacun de ces cas, la dispersion des odeurs au moyen d'un modèle de dispersion atmosphérique, il est alors possible de vérifier si les limitations spatio-temporelles ainsi déterminées par les percentiles, sur base de débits d'odeur fournis par la littérature, sont cohérentes avec les distances préconisées par les lignes-guides. Les résultats de ces deux premières étapes peuvent alors servir à jeter les bases d'une méthode adaptée à la Wallonie. [less ▲]

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See detailFeeding of planktonic rotifers on ciliates: a method using natural ciliate assemblages labelled with fluorescent microparticles
Joaquim-Justo, Célia ULg; Detry, Cédric ULg; Caufman, F. et al

in Journal of Plankton Research (2004), 26(11), 1289-1299

A method was developed to allow direct measurements of predation exerted by metazooplankton on ciliates. The method relied on the use of ciliates labelled with fluorescent microparticles (FMP). Optimal ... [more ▼]

A method was developed to allow direct measurements of predation exerted by metazooplankton on ciliates. The method relied on the use of ciliates labelled with fluorescent microparticles (FMP). Optimal labelling conditions were determined with ciliates from cultures (Tetrahymena pyriformis) and with natural ciliate assemblages sampled in a river. Labelled T. pyriformis were used as tracer food to determine gut passage time (GPT) and ingestion rates of the rotifer Brachionus calyciflorus in the laboratory. Predation of metazooplankton from the lowland river Meuse (Belgium) was determined by labelling natural assemblages of ciliates and using them as tracer food for metazooplankters sampled in the river. Optimal labels of ciliates, i.e. sharp distribution of FMP in cells, were obtained with short incubations (10 min) and low FMP concentrations (1 x 10(5) mL(-1)). GPT varied between 30 and 45 min for B. calyciflorus and from 25 up to >35 min for rotifers from the river. The ingestion rate of B. calyciflorus fed with T. pyriformis was 3.3 +/- 0.6 ciliate rot(-1) h(-1), i.e. 1.4 +/- 0.3 ngC rot(-1) h(-1). Metazooplankton species for which the ingestion of ciliates could be measured were the rotifers Keratella cochlearis, Euchlanis dilatata and Synchaeta spp. Ingestion rates measured ranged from 0.4 to 12.5 ngC rot(-1) h(-1). The method proposed proved to be useful in estimating the predation of microplankton on ciliates in semi- in situ conditions; in further developments, labelled natural assemblages of ciliates could be used for in situ incubations with the Haney chamber. [less ▲]

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See detailInterférométrie holographique sur base de cristaux photoréfractifs dynamiques et lasers à double impulsion : le projet européen PHIFE
Georges, Marc ULg; Thizy, Cédric ULg; Lemaire, Philippe et al

in Smigielski, P. (Ed.) Actes du Cinquième colloque francophone Méthodes et Techniques Optiques pour l'Industrie (2004, November)

Les cristaux photoréfractifs sont des supports holographiques dynamiques (auto-enregistrables, effaçables et indéfiniment réutilisables) qui permettent l'acquisition rapide d'hologrammes utilisables en ... [more ▼]

Les cristaux photoréfractifs sont des supports holographiques dynamiques (auto-enregistrables, effaçables et indéfiniment réutilisables) qui permettent l'acquisition rapide d'hologrammes utilisables en interférométrie holographique. De plus, certaines de leurs propriétés cristallines permettent l'obtention d'interférogrammes de qualité incomparable. Nous avons déjà présenté à maintes reprises les développements et applications d'instruments de métrologie basés sur ces cristaux avec des lasers continus. Des expériences préliminaires sur base de lasers à simple impulsion avaient aussi été montrées. Nous présentons ici la suite de ces expériences et qui ont lieu dans le cadre du projet européen PHIFE "Pulsed Holographic Interferometer for the analysis of Fast Events". PHIFE a pour objectif le développement d'un instrument à champ complet fonctionnant avec un laser YAG Q-switch à double impulsion. [less ▲]

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See detailQualification de grands réflecteurs en environnement spatial
Thizy, Cédric ULg; Stockman, Yvan ULg; Doyle, Dominic et al

in Smigielski, P. (Ed.) Actes du Cinquième colloque francophone Méthodes et Techniques Optiques pour l'Industrie (2004, November)

Les nouvelles générations de télescopes spatiaux dans le domaine infrarouge nécessitent des réflecteurs de grandes dimensions et de haute qualité. Ceux-ci, pour des raisons de poids, sont basés sur les ... [more ▼]

Les nouvelles générations de télescopes spatiaux dans le domaine infrarouge nécessitent des réflecteurs de grandes dimensions et de haute qualité. Ceux-ci, pour des raisons de poids, sont basés sur les technologies des matériaux composites dont les comportements aux basses températures sont mal connus. Une méthode par interférométrie holographique de vérification et de validation en environnement spatial de ce type de réflecteurs est présentée. Elle est basée sur l'utilisation d'une caméra holographique dynamique observant un dépoli sur lequel est projeté le faisceau objet venant de la surface réfléchissante. Outre une augmentation de la dynamique de mesure, cette méthode offre l’avantage principal, par rapport aux techniques d’interférométrie optique, de ne pas nécessiter de système optique d’adaptation du front d’onde au réflecteur à mesurer et donc un gain de flexibilité majeur pour des formes exotiques de réflecteurs (types asphériques). Le système de mesure a été calibré avec un interféromètre ponctuel à effet Doppler. L'influence des différentes sources d’erreur du système sur la mesure a été évaluée. Cette évaluation a porté principalement sur des aspects vibratoires et thermiques. Ces réflecteurs devant être testés sous vide et à basses températures, le système de mesure a été rendu compatible à ces conditions. Des éléments de la caméra holographique (objectifs, CCD, cristal, fibre optique) ont été adaptés et testés sous vide. La certification métrologique de l’ensemble du système sera réalisée par la mesure d'une antenne parabolique, de 1.1 m de diamètre de comportement connu et placée dans un environnement spatial simulé. Le test consistera à mesurer les déplacements et déformations de l'antenne entre un état initial à la température ambiante, et un état final à une température d'environ 130K. [less ▲]

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See detailL’édition à l’heure des trous noirs
Durand, Pascal ULg

Article for general public (2004)

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See detailAt the crossing of physics and Aercheology : the OSIRIS project
Renotte, Yvon ULg; Laboury, Dimitri ULg; Tilkens, Bernard et al

in Europhysics News (2004), 35/6

How physics can help aercheology, including a path to the parket

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See detailTraitement de l'osteoporose postmenopausique en 2004
Reginster, Jean-Yves ULg; Devogelaer, Jean-Pierre

in Revue Médicale de Liège (2004), 59(11), 633-47

Major improvements have been observed, during the last ten years, in the management of postmenopausal osteoporosis. The most significant benefits have been obtained through the availability of new ... [more ▼]

Major improvements have been observed, during the last ten years, in the management of postmenopausal osteoporosis. The most significant benefits have been obtained through the availability of new medications which have demonstrated their anti-fracture efficacy in the course of well conducted, scientifically sound studies. Due to the pharmacological properties of these new medications, treatment of osteoporosis can now be tailored to the needs of each and every single postmenopausal woman. Calcium supplementation (500 mg/day) should be offered to all post menopausal women unless dietary records show a sufficient intake. On the grounds of the high prevalence of low serum vitamin D levels in the ederly Belgian population, the systematic use of a calcium-vitamin D combination, after the age of 65 years, appears to be justified. Raloxifene is an interesting option for women with low mineral density or prevalent vertebral fractures. This molecule has demonstrated unequivocal anti-fracture efficacy at the level of the spine and is also caracterized by a beneficial effect on non-spinal fractures, in high risk women. Bisphosphonates (alendronate and risedronate) have shown the anti-fracture efficacy at the level of the axial and appendicular skeleton. The availability of a weekly formulation improves their compliance, notwithstanding the constrains related to the potential upper gastro-intestinal toxicity of these compounds. Bisphosphonates appear to be the first-line choice for patients with more severe osteoporosis and high risk to develop hip fractures. Teriparatide (1-34 Fragment of parathyroid hormone) is a new pharmacological option, oriented, mainly if not exclusively because of its parenteral administration and high cost, to patients with severe osteoporosis (low bone density and prevalent vertebral fracture(s). Strontium ranelate offers an anti-fracture efficacy at all skeleton sites and an oustanding overall tolerance and may play a main role in the future management of osteoporosis. [less ▲]

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See detailHow many women can benefit from a full intrapartum antibiotic prphylaxis for prevention of perinatal group B streptococcal disease?
MELIN, Pierrette ULg; Lorquet, Sophie; Rodriguez Cuns, Grisel et al

in American Society of Microbiology (Ed.) Program and Abstracts of the 44th Intersciences Conference on Antimicrobial Agents and Chemotherapy (2004, November)

Background: In Belgium as in many Western countries, GBS are still the leading cause of severe perinatal infections. Current guidelines for prevention recommend intrapartum antimicrobial prohylaxis (IAP ... [more ▼]

Background: In Belgium as in many Western countries, GBS are still the leading cause of severe perinatal infections. Current guidelines for prevention recommend intrapartum antimicrobial prohylaxis (IAP) administered promptly before delivery to pregnant women colonized with GBS. The risk of vertical GBS transmission to the newborn decreases as the duration of prophylaxis increases. The considered threshold for prophylaxis adequacy is the first dose administered at least 4 hours before delivery. Objective: To evaluate the proportion of pregnant women who could benefit from an adequate IAP for the prevention of GBS perinatal infections. Methods: Between June and October 2003, we recorded in two hospitals the elapse time between admission for labor and delivery. We assumed 5 hours represent a useful threshold to allow admission, revision of chart and administration of adequate IAP. The status of vaginal colonization with GBS was determined by CDC’s recommended culture method with Granada agar added. Results: Among 532 women, 27.3 % delivered within 5 hours after admission for labor. The colonization rate for GBS was 25.6 %. The distribution of elapse time between admission and delivery for GBS colonized pregnant women was not significantly different from non colonized women (p <= 1). Conclusions: 1) With the current prevention strategy, 27.3 % of these pregnant women would not have benefit from adequate prophylaxis 2) These results highlight the importance of an efficient organization to warranty prompt administration of IAP as soon as possible when mandatory. 3) If a rapid intrapartum screening test is used, no delay can be afforded “from ward to bench to bed”. [less ▲]

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See detailReal-Time PCR detection of group B streptococci from pregnant women's vaginal specimens at time of delivery: clinical evaluation
MELIN, Pierrette ULg; Rodriguez Cuns, Grisel; Lorquet, Sophie et al

in American Society of Microbiology (Ed.) Program and Abstracts of the 44th Intersciences Conference on Antimicrobial Agents and Chemotherapy (2004, November)

Guidelines for prevention recommend intrapartum antimicrobial prohylaxis (IAP) for pregnant women with a positive prenatal culture-based screening for GBS. To improve this strategy, a rapid screening ... [more ▼]

Guidelines for prevention recommend intrapartum antimicrobial prohylaxis (IAP) for pregnant women with a positive prenatal culture-based screening for GBS. To improve this strategy, a rapid screening performed at the onset of labor with the IDI-Strep BTM test (IDI), a real time PCR detection (Infectio Diagnostic), may be used. Objective: To evaluate the performance of the IDI to detect GBS from vaginal specimens collected at time of delivery. Methods: Intrapartum vaginal specimens from 923 pregnant women were tested to determine the status of GBS colonization, by CDC’s recommended culture method (including selective LIM broth) with a Granada agar (GR) added as well as by the IDI and the immunologic StrepB OIATM test (OIA), BioStar. The performance of the different methods was compared. Results: GBS were recovered from 16.8% and 23.6% specimens respectively on primary culture plates and overall. The colonization rate for GBS was 18.6 % by IDI and 15.7 % by OIA testing. The sensitivity of IDI for identifying vaginal colonization status at delivery was 92 % or 77.1 % when compared to GR primary cultures or to overall culture results, and for the OIA, it was respectively 65.1 or 52.1 %. The specificity was 99.1 % for IDI and 95.5 % for OIA. The turnaround time for obtaining results was less than one hour for both IDI and OIA. Conclusions: 1) Strep B-IDI test, performed on intrapartum vaginal specimens, yields relevant results rapidly enough to be used as an efficient diagnostic tool for the identification of GBS colonized women, in order to offer IAP really targeted to GBS carriers. 2) By comparison to the prenatal screening-based strategy, the high sensitivity and specificity of IDI would allow a reduction of useless IAP and of missed opportunities. 3) IDI testing might be implemented “in routine” in some hospitals for further clinical and practical evaluation. [less ▲]

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See detailExtreme catalysts from low-temperature environments
Hoyoux, A.; Blaise, Vinciane ULg; Collins, T. et al

in Journal of Bioscience & Bioengineering (2004), 98(5), 317-330

Cold-loving or psychrophilic organisms are widely distributed in nature as a large part of the earth's surface is at temperatures around 0 degrees C. To maintain metabolic rates and to prosper in cold ... [more ▼]

Cold-loving or psychrophilic organisms are widely distributed in nature as a large part of the earth's surface is at temperatures around 0 degrees C. To maintain metabolic rates and to prosper in cold environments, these extremophilic organisms have developed a vast array of adaptations. One main adaptive strategy developed in order to cope with the reduction of chemical reaction rates induced by low temperatures is the synthesis of cold-adapted or psychrophilic enzymes. These enzymes are characterized by a high catalytic activity at low temperatures associated with a low thermal stability. A study of protein adaptation strategies suggests that the high activity of psychrophilic enzymes could be achieved by the destabilization of the active site, allowing the catalytic center to be more flexible at low temperatures, whereas other protein regions may be destabilized or as rigid as their mesophilic counterparts. Due to these particular properties, psychrophilic enzymes offer a high potential not only for fundamental research but also for biotechnological applications. [less ▲]

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See detailDifferent patterns of insulin resistance in relatives of type 1 diabetic patients with retinopathy or nephropathy
Hadjadj, S.; Pean, F.; Pean, F. et al

in Diabetes Care (2004), 27(11), 2661-2668

OBJECTIVE- Insulin resistance may be a risk factor for diabetic microangiopathy, which may have a familial component. We carried out a family-based study to determine which components of the insulin ... [more ▼]

OBJECTIVE- Insulin resistance may be a risk factor for diabetic microangiopathy, which may have a familial component. We carried out a family-based study to determine which components of the insulin resistance syndrome are associated with diabetic retinopathy and nephropathy in type 1 diabetes. RESEARCH DESIGN AND METHODS- The Genesis France-Belgium Study is a multicenter binational study designed to investigate the genetic factors involved in the microvascular complications of type 1 diabetes using a family-based design. Probands were type 1 diabetic patients with diabetic retinopathy (classified as background, preproliferative, or proliferative) and possibly diabetic nephropathy (absent, incipient, established, or advanced). The insulin resistance score of their first-degree relatives was calculated according to their BMI and history of arterial hypertension, lipid disorders, and type 2 diabetes. RESULTS- The insulin resistance score of relatives was positively correlated with the albumin excretion rate (P = 0.0009) and fasting plasma glucose (P = 0.0003) and HbA(1c) (P < 0.0001) concentrations. This score was higher in the relatives of probands with than in those without diabetic nephropathy (P = 0.0370). Similarly, it was higher in relatives of subjects with proliferative diabetic retinopathy than in those of probands without, even after controlling for subjects with versus without diabetic nephropathy (P = 0.0379). However, the components of the insulin resistance score in relatives differed according to the severity of diabetic retinopathy or nephropathy in the probands. Obesity and history of arterial hypertension were most common in relatives of probands with proliferative diabetic retinopathy, whereas obesity and history of lipid disorders were most common in the relatives of probands with diabetic nephropathy. CONCLUSIONS- Familial insulin resistance segregates with diabetic complications: lipid disorders and obesity segregate with diabetic nephropathy, whereas arterial hypertension and obesity segregate with diabetic retinopathy. [less ▲]

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See detailHuman chorionic gonadotropin and growth factors at the embryonic-endometrial interface control leukemia inhibitory factor (LIF) and interleukin 6 (IL-6) secretion by human endometrial epithelium
PERRIER d'HAUTERIVE, Sophie ULg; Charlet, Jeanne de Chantal ULg; Berndt, Sarah ULg et al

in Human Reproduction (2004), 19(11), 2633-2643

BACKGROUND: The elucidation of the molecular mechanisms by which the embryo contributes to its implantation is an area of extensive research. The main objective of this study was to investigate the ... [more ▼]

BACKGROUND: The elucidation of the molecular mechanisms by which the embryo contributes to its implantation is an area of extensive research. The main objective of this study was to investigate the pattern of leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) secretion by human endometrial epithelium, and their regulation by human chorionic gonadotropin (hCG) and other growth factors present at the embryonic-endometrial interface. METHODS: Endometrial epithelial cells (EEC) were isolated from biopsies collected at both proliferative and secretory phases of fertile women. RESULTS: HCG (1-50 IU/ml) increased LIF secretion by EEC cultures derived from follicular phase (up to 285+/-75%) or from secretory phase (up to 212+/-16%). In contrast, hCG reduced IL-6 secretion by EEC in both phases. The hCG/LH receptor gene was transcribed by EEC as evidenced by RT-PCR. Insulin-like growth factors 1 and 2 increased LIF secretion by EEC. Transforming growth factor beta1 stimulated LIF and reduced IL-6 secretion. CONCLUSIONS: Through hCG, the blastocyst may be involved in the control of its implantation (via an increase of proimplantatory LIF) and tolerance (via an inhibition of proinflammatory IL-6). Other growth factors present at the embryonic-endometrial interface are also involved in the control of LIF and IL-6 endometrial secretion. [less ▲]

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See detailLumiracoxib is effective in the treatment of osteoarthritis of the knee: a 13 week, randomised, double blind study versus placebo and celecoxib
Tannenbaum, H.; Berenbaum, F.; Reginster, Jean-Yves ULg et al

in Annals of the Rheumatic Diseases (2004), 63(11), 1419-1426

Objectives: To compare the efficacy and safety of lumiracoxib with placebo and celecoxib for osteoarthritis (OA) in a 13 week, multicentre, randomised, double blind study. Methods: After a 327 day washout ... [more ▼]

Objectives: To compare the efficacy and safety of lumiracoxib with placebo and celecoxib for osteoarthritis (OA) in a 13 week, multicentre, randomised, double blind study. Methods: After a 327 day washout period for non-steroidal anti-inflammatory drugs, 1702 patients with knee OA were randomised to lumiracoxib 200 or 400 mg once daily (od), celecoxib 200 mg od, or placebo (2:2:2:1). A visual analogue scale (VAS) pain intensity greater than or equal to40 mm was required. Primary efficacy variables were OA pain intensity (VAS mm) in the target knee, patient's global assessment of disease activity (VAS mm), and WOMAC pain subscale and total scores at 13 weeks. OA pain intensity, patient's and physician's global assessment of disease activity, and WOMAC (total and all subscale scores) were analysed by visit as secondary variables. Results: Lumiracoxib showed significant improvements in all primary and secondary variables compared with placebo. Lumiracoxib 200 mg od and celecoxib 200 mg od achieved similar improvements in OA pain intensity and functional status. Lumiracoxib 400 mg od demonstrated better efficacy for OA pain intensity and patient's global assessment of disease activity at weeks 2, 4, and 8 and similar efficacy at week 13 compared with celecoxib 200 mg od. The incidence of adverse events (AEs), serious AEs, and discontinuations due to AEs was similar in each group. Conclusion: Lumiracoxib demonstrated significant improvement in OA pain intensity, patient's global assessment of disease activity, and the WOMAC pain subscale and total scores compared with placebo. Lumiracoxib was well tolerated in this study, with overall tolerability similar to that of placebo and celecoxib. [less ▲]

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See detailCaractérisation de la farnésyle pyrophosphate synthase de pucerons
Beliveau, Catherine; Vandermoten, Sophie ULg; Francis, Frédéric ULg et al

Poster (2004, November)

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