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See detailNew radioiodinated carboxylic and hydroxamic matrix metalloproteinase inhibitor tracers as potential tumor imaging agents
Oltenfreiter, R.; Staelens, L.; Lejeune, Annabelle ULg et al

in Nuclear Medicine & Biology (2004), 31(4), 459-468

Several studies have demonstrated a positive correlation between tumor progression and expression of extracellular proteinases such as matrix metalloproteinases (MMPs). MMP-2 and MMP-9 have become ... [more ▼]

Several studies have demonstrated a positive correlation between tumor progression and expression of extracellular proteinases such as matrix metalloproteinases (MMPs). MMP-2 and MMP-9 have become attractive targets for cancer research because of their increased expression in human malignant tumor tissues of various organs, providing a target for medical imaging techniques. Radioiodinated carboxylic and hydroxamic MMP inhibitors 2-(4'-[123]iodo-biphenyl-4-sulfonylainino)-3-(1H-indol-3-yl)-propionic acid (9) and 2-(4'-[I-123] iodo-biphenyl-4-sulfonylamino)-3-(1H-indol-3-yl)-propionamide (11) were synthesized by electrophilic aromatic substitution of the tributylstannyl derivatives and resulted in radiochemical yields of 60% +/- 5% (n - 3) and 70% +/- 5% (n = 6), respectively. In vitro zymography and enzyme assays showed high inhibition capacities of the inhibitors on gelatinases. In vivo biodistribution showed no long-terin accumulation in organs and the possibility to accumulate in the tumor. These results warrant further studies of radioiodinated carboxylic and hydroxamic MNIP inhibitor tracers as potential SPECT tumor imaging agents. (C) 2004 Elsevier Inc. All rights reserved. [less ▲]

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See detailMontage et gestion budgétaire
Van Caillie, Didier ULg; Marthoz, Cédric

Learning material (2004)

This seminar overviews key elements that are necessary to plan and to budget new projects. An application is realized in the context of an international cooperation project.

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See detailLes émulsifiants dans les produits de boulangerie industrielle : modes d'action, rôles et utilisations.
Delacharlerie, Sophie ULg; Blecker, Christophe ULg; Kegelaers, Yves et al

in Industries Alimentaires et Agricoles (2004), (Mai), 8-14

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See detailRolling and slipping motion of Euler's disk
Caps, Hervé ULg; Dorbolo, Stéphane ULg; Ponte, S. et al

in Physical Review E (2004), 69(5, Pt 2), 56610

We present an experimental study of the motion of a circular disk spun onto a table. With the help of a high speed video system, the temporal evolution of (i) the inclination angle alpha, (ii) the angular ... [more ▼]

We present an experimental study of the motion of a circular disk spun onto a table. With the help of a high speed video system, the temporal evolution of (i) the inclination angle alpha, (ii) the angular velocity omega, and (iii) the precession rate Omega are studied. The influence of the mass of the disk as well as the friction between the disk and the supporting surface are considered. Both inclination angle and angular velocity are observed to decrease according to a power law. We also show that the precession rate diverges as the motion stops. Measurements are performed very near the collapse as well as on long range times. Times to collapse have been also measured. Results are compared with previous theoretical and experimental works. The major source of energy dissipation is found to be the slipping of the disk on the plane. [less ▲]

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See detailContributions of benthic and planktonic primary producers to nitrate and ammonium uptake fluxes in a nutrient-poor shallow coastal area (Corsica, NW Mediterranean)
Lepoint, Gilles ULg; Gobert, Sylvie ULg; Dauby, Patrick ULg et al

in Journal of Experimental Marine Biology and Ecology (2004), 302(1), 107-122

By using the stable isotope N-15, we have measured in situ the uptake of nitrate and ammonium by the seagrass Posidonia oceanica, its leaf epiphyte community, the brown macroalgae Halopteris scoparia and ... [more ▼]

By using the stable isotope N-15, we have measured in situ the uptake of nitrate and ammonium by the seagrass Posidonia oceanica, its leaf epiphyte community, the brown macroalgae Halopteris scoparia and the suspended particulate organic matter (SPOM). In Revellata Bay (Gulf of Calvi, Westem Corsica), which is a very nutrient-poor region, the specific uptake rates (V) (mug N g N 1 h(- 1)) of SPOM measured at ambient concentrations are 10-1000 higher than those of benthic primary producers. Macroalgae have intermediary v, between the seagrass leaf and leaf epiphytes. V are quite variable and the reasons for this variability remain unclear. Despite the difference of specific uptake rates found between benthic and pelagic primary producers, when integrating the uptake fluxes for a water Column of 10 m depth, the contribution of benthic primary producers to N uptake fluxes (g N m(-) (2) h(-) (1)) is significant, corresponding on average to 40% of total uptake flux. This results from the dominance in terms of N biomass of benthic primary producers in this shallow nutrient-poor area. When reported for the entire volume of the Revellata Bay, the contribution of benthic primary producers is reduced to 5 - 10% of total N uptake flux. Although this contribution could appear relatively low, it results in a significant direct transfer of inorganic nitrogen from the water column to the benthic compartment. By this transfer, the benthic plants act as a biological pump incorporating the pelagic N into the benthic compartment for a time longer than the characteristic time of phytoplankton dynamics (month-years vs. day-week). (C) 2003 Elsevier B.V. Alt rights reserved. [less ▲]

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See detailLa passe et le témoin. Une épistémologie pour la sémiotique
Badir, Sémir ULg

Scientific conference (2004, April 23)

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See detailLes Paradoxes de l'Autonomie
Stassart, Martine ULg

Conference given outside the academic context (2004)

How is it possible for an adolescent to become autonomous in spite of the necessity to introject some qualities of the others (parents, teachers and so on).

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See detailHow to introduce "Geography" into databases?
Donnay, Jean-Paul ULg

Scientific conference (2004, April 21)

Form and content of spatial data. Geographic versus cartographic data? Software solutions: mapping software, Desktop GIS, Enterprise GIS. Database models: Flat relational, Spatial-enabled database ... [more ▼]

Form and content of spatial data. Geographic versus cartographic data? Software solutions: mapping software, Desktop GIS, Enterprise GIS. Database models: Flat relational, Spatial-enabled database. Required standards. GIS architecture today. [less ▲]

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See detailElectrochemical formation of polypyrrole nanowires
Jérôme, Christine ULg; Labaye, David; Jérôme, Robert ULg

in Synthetic Metals (2004), 142(1-3), 207-216

This paper aims at approaching the mechanism of formation of polypyrrole (PPy) nanowires by an all-electrochemical process, which consists in electrografting a poly(alkylacrylate) film onto the surface of ... [more ▼]

This paper aims at approaching the mechanism of formation of polypyrrole (PPy) nanowires by an all-electrochemical process, which consists in electrografting a poly(alkylacrylate) film onto the surface of a cathode, followed by the anodic electropolymerization of pyrrole (Py) at the surface of this organomodified electrode. The experimental conditions for the pyrrole oxidation, including solvent and concentrations of monomer and supporting electrolyte, have been changed with the purpose to tune the characteristic features of the polypyrrole nanowires. The polyacrylate template has also been modified, all other conditions being the same, in an effort to design the shape and size of the wires. The electrochemical behavior of the as-prepared PPy wires has been characterized. [less ▲]

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See detailNafion-layered silicate nanocomposite membrane for fuel cell application
Thomassin, Jean-Michel ULg; Pagnoulle, Christophe; Bizzari, Didier et al

in e-Polymers (2004), (18), 1-13

Direct methanol fuel cells (DMFCs) using a proton exchange membrane as electrolyte is an attractive option for electricity generation. The most widely used membrane in the DMFC system is based on a ... [more ▼]

Direct methanol fuel cells (DMFCs) using a proton exchange membrane as electrolyte is an attractive option for electricity generation. The most widely used membrane in the DMFC system is based on a perfluorinated polymer bearing sulfonic acid functions like Nafion®. The latter combines chemical, mechanical and thermal stability and high protonic conductivity but shows elevated methanol permeability. We propose the preparation of a novel type of hybrid membranes to tentatively solve this problem. This innovative material results from the homogeneous dispersion of a nano-scaled inorganic filler within Nafion. The filler consists of stacks of negatively charged alumino-silicate layers (Cloisite), with a positive counter-ion in the interlamellar space. The purpose of the addition of this filler is to decrease methanol diffusion through the polymer membrane without decreasing too much the ionic conductivity. [less ▲]

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See detailA tavola con la natura morta. Quando non resta che consumare il sacro
Dondero, Maria Giulia ULg

in Espressione/Contenuto : Rivista dell’Associazione Italiana di Studi Semiotici (2004, April 11)

Cet article étudie la relation intertextuelle et intersémiotique entre le genre de la nature morte entendue comme Vanitas et Memento mori, la tradition picturale de l’« Et in Arcadia Ego » et quelques ... [more ▼]

Cet article étudie la relation intertextuelle et intersémiotique entre le genre de la nature morte entendue comme Vanitas et Memento mori, la tradition picturale de l’« Et in Arcadia Ego » et quelques photos contemporaines. [less ▲]

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See detailMethod for producing functionalized alkoxyamine initiator and use thereof
Detrembleur, Christophe ULg; Gross, Thomas; Meyer, Rolf-Volker

Patent (2004)

PROBLEM TO BE SOLVED: To provide a method for producing a functionalized alkoxyamine initiator and its use in radical polymerization process. ; SOLUTION: The invention provides a one-pot process for the ... [more ▼]

PROBLEM TO BE SOLVED: To provide a method for producing a functionalized alkoxyamine initiator and its use in radical polymerization process. ; SOLUTION: The invention provides a one-pot process for the production of a functionalized alkoxyamine of general formula (I) (for example, R<SP>1</SP>and R<SP>2</SP>are each H; R<SP>3</SP>is phenyl; and R<SP>4</SP>and R<SP>5</SP>together with nitrogen atom form an alicyclic 6-membered ring). The method includes (1) the formation of an aqueous phase and nitroxyl radical by reacting an oxidizing agent with a secondary amine having steric hindrance and (2) the removal of the aqueous phase and the addition of one or more vinyl monomers to the nitroxyl radical according to the method and system for the production of the radical. The invention further provides a monomer polymerization method using the functionalized alkoxyamine. [less ▲]

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See detailRoles and competencies of the e-tutor
Denis, Brigitte ULg; Watland, Philip; Pirotte, Sébastien et al

in Banks, S.; Goodyear, P.; Hogdson, V. (Eds.) et al Networked learning 2004 : a research based conference on networked learning and lifelong learning : proceedings of the fourth international conference, Lancaster (2004, April 07)

This paper considers the roles and competencies of the e-tutor. A literature review shows that different roles are assigned to the online tutors. Definitions of these roles are presented and discussed ... [more ▼]

This paper considers the roles and competencies of the e-tutor. A literature review shows that different roles are assigned to the online tutors. Definitions of these roles are presented and discussed. Afterwards, we present eleven roles we consider important to manage the interactions between learners and tutors in an e-learning environment and the competencies needed to support these tutor’s roles. We conclude that to improve the quality of e-learning the tutor’s interventions have to be adapted to a specific context and we propose to train the e-tutors for these roles. [less ▲]

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See detailDevelopment of optical ground verification method for mu m to sub-mm reflectors
Stockman, Yvan ULg; Thizy, Cédric ULg; Lemaire, Philippe ULg et al

in Warmbein, B. (Ed.) Proceedings of the 5th International Conference on Space Optics (ICSO) (2004, April 02)

Large reflectors and antennas for the IR to mm wavelength range are being planned for many Earth observation and astronomical space missions and for commercial communication satellites as well. The ... [more ▼]

Large reflectors and antennas for the IR to mm wavelength range are being planned for many Earth observation and astronomical space missions and for commercial communication satellites as well. The challenging tasks of on-ground testing are to achieve the required accuracy in the measurement of the reflector shapes and antenna structures and to verify their performance under simulated space conditions (vacuum, low temperatures). A small number of infrared interferometers have been commercially developed over the last 10 years but their applications have also been limited due to poor dynamic range and the restricted spatial resolution of their detectors. It has therefore been considered essential, from the viewpoint of supporting future ESA exploration missions, to develop and realise suitable verification tools based on infrared interferometry and other optical techniques for testing large reflector structures, telescope configurations and their performances under simulated space conditions. Two methods and techniques are developed at CSL. The first one is an IR-phase shifting interferometer with high spatial resolution. This interferometer shall be used specifically for the verification of high precision IR, FIR and sub-mm reflector surfaces and telescopes under both ambient and thermal vacuum conditions. The second one presented hereafter is a holographic method for relative shape measurement. The holographic solution proposed makes use of a home built vacuum compatible holographic camera that allows displacement measurements from typically 20 nanometres to 25 microns in one shot. An iterative process allows the measurement of a total of up to several mm of deformation. Uniquely the system is designed to measure both specular and diffuse surfaces [less ▲]

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See detailUp-regulation of vascular endothelial growth factor-A by active membrane-type 1 matrix metalloproteinase through activation of Src-tyrosine kinases
Sounni, Nor Eddine ULg; Roghi, C.; Chabottaux, Vincent et al

in Journal of Biological Chemistry (2004), 279(14), 13564-13574

Membrane-type 1 matrix metalloproteinase (MT1-MMP) and vascular endothelial growth factor ( VEGF) are two key molecules involved in pericellular proteolysis and cell proliferation during tumor growth and ... [more ▼]

Membrane-type 1 matrix metalloproteinase (MT1-MMP) and vascular endothelial growth factor ( VEGF) are two key molecules involved in pericellular proteolysis and cell proliferation during tumor growth and angiogenesis. Our previous data showed that MT1-MMP overexpression in human breast carcinoma MCF7 cells induced an up-regulation of VEGF expression. This effect was associated in vivo with accelerated tumor growth and angiogenesis. We now provide evidence that MT1-MMP overexpression specifically affected VEGF-A production and failed to influence that of other VEGF family members ( VEGF, B, C, D, or PlGF) or their receptors. The up-regulation of VEGF-A by MT1-MMP was related to an increased transcriptional activation rather than to a modification of mRNA stability. It was blocked by synthetic MMP inhibitors, TIMP2, but not TIMP-1 and abolished by a partial deletion of the catalytic domain or the cytoplasmic tail of MT1-MMP. Analysis of the signal transduction mechanisms demonstrated that MT1-MMP acts through a signaling pathway involving Src tyrosine kinases. Thus, our results provide new insight into the mechanisms of action of MT1-MMP during angiogenesis and suggest that the full enzymatic activity of MT1-MMP is required for a specific up-regulation of VEGF-A through an activation of Src tyrosine kinase pathways. [less ▲]

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See detailRéforme, université et compétence
VIERSET, Viviane ULg

Learning material (2004)

Adaptation des objectifs de l’enseignement universitaire à une logique d’entreprise ? Mise en parallèle des objectifs-enjeux de l'enseignement et des objectifs-enjeux de l'entreprise : exemples de l ... [more ▼]

Adaptation des objectifs de l’enseignement universitaire à une logique d’entreprise ? Mise en parallèle des objectifs-enjeux de l'enseignement et des objectifs-enjeux de l'entreprise : exemples de l'enseignement supérieur au Maroc versus en CfWB. [less ▲]

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See detailToxicomanie: prise en charge du nouveau-né
Battisti, Oreste ULg

Scientific conference (2004, April 01)

présentation concernant la prise en charge globale du nouveau-né issu d'une pharmacodpéndnace

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See detailL'astronomie dans le monde
Manfroid, Jean ULg

Article for general public (2004)

Sedna; Galaxies lointaines; Anneaux de Neptune; Eau sur Mars

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