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See detailUnderstanding bilingual memory: models and data
French, R.; Jacquet, Maud ULg

in Trends in Cognitive Sciences (2004), 8(2), 87-93

Bilingual memory research in the past decade and, particularly, in the past five years, has developed a range of sophisticated experimental, neuropsychological and computational techniques that have ... [more ▼]

Bilingual memory research in the past decade and, particularly, in the past five years, has developed a range of sophisticated experimental, neuropsychological and computational techniques that have allowed researchers to begin to answer some of the major long-standing questions of the field. We explore bilingual memory along the lines of the conceptual division of language knowledge and organization, on the one hand, and the mechanisms that operate on that knowledge and organization, on the other. Various interactive-activation and connectionist models of bilingual memory that attempt to incorporate both organizational and operational considerations will serve to bridge these two divisions. Much progress has been made in recent years in bilingual memory research, which also serves to illuminate general (language-independent) memory processes. [less ▲]

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See detailSustained antihypertensive activity of telmisartan vs valsartan
Lacourciere, Yves; Krzesinski, Jean-Marie ULg; White, William et al

Poster (2004, February)

DBP reduction in the last 6 h of the once-daily dosing interval and 24-h mean DBP control when a dose is missed are significantly superior with telmisartan than with valsartan. Thus, telmisartan due to ... [more ▼]

DBP reduction in the last 6 h of the once-daily dosing interval and 24-h mean DBP control when a dose is missed are significantly superior with telmisartan than with valsartan. Thus, telmisartan due to its longer half-life offers more sustained BP control, especially at the end of the dosing period and provides sustained efficacy in poorly compliant patients. [less ▲]

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See detailCONVENTION ''PLAN DE L'AIR EN REGION WALLONNE'' Rapport final – Partie ''odeurs'' Etude comparative des différentes méthodes de caractérisation quantitative et qualitative des odeurs dans l'environnement dans le but de déterminer une méthode applicable en région wallonne.
Nicolas, Jacques ULg; Craffe, Flavien

Report (2004)

The report presents a part of a complete study aiming at inventory policies, standards and measurement methods for air quality assessment. It concerns more particularly the "odour" part and considers ... [more ▼]

The report presents a part of a complete study aiming at inventory policies, standards and measurement methods for air quality assessment. It concerns more particularly the "odour" part and considers qualitative and quantitative methods, key odorous compounds, standards and guidelines for odour assessment. [less ▲]

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See detailAdenylation-dependent conformation and unfolding pathways of the NAD(+)-dependent DNA ligase from the thermophile Thermus scotoductus
Georlette, D.; Blaise, Vinciane ULg; Bouillenne, Fabrice ULg et al

in Biophysical Journal (2004), 86(2), 1089-1104

In the last few years, an increased attention has been focused on NAD(+)-dependent DNA ligases. This is mostly due to their potential use as antibiotic targets, because effective inhibition of these ... [more ▼]

In the last few years, an increased attention has been focused on NAD(+)-dependent DNA ligases. This is mostly due to their potential use as antibiotic targets, because effective inhibition of these essential enzymes would result in the death of the bacterium. However, development of an efficient drug requires that the conformational modifications involved in the catalysis of NAD(+)-dependent DNA ligases are understood. From this perspective, we have investigated the conformational changes occurring in the thermophilic Thermus scotoductus NAD(+)-DNA ligase upon adenylation, as well as the effect of cofactor binding on protein resistance to thermal and chemical (guanidine hydrochloride) denaturation. Our results indicate that cofactor binding induces conformational rearrangement within the active site and promotes a compaction of the enzyme. These data support an induced "open-closure" process upon adenylation, leading to the formation of the catalytically active enzyme that is able to bind DNA. These conformational changes are likely to be associated with the protein function, preventing the formation of nonproductive complexes between deadenylated ligases and DNA. In addition, enzyme adenylation significantly increases resistance of the protein to thermal denaturation and GdmCl-induced unfolding, establishing a thermodynamic link between ligand binding and increased conformational stability. Finally, chemical unfolding of deadenylated and adenylated enzyme is accompanied by accumulation of at least two equilibrium intermediates, the molten globule and premolten globule states. Maximal populations of these intermediates are shifted toward higher GdmCl concentrations in the case of the adenylated ligase. These data provide further insights into the properties of partially folded intermediates. [less ▲]

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See detailNumerical modelling of steel beam-columns in case of fire - comparisons with Eurocode 3
Vila Real, Paulo; Lopes, Nuno; da Silva, Luis Simoes et al

in Fire Safety Journal (2004), 39(1), 23-39

This paper presents a numerical study of the behaviour of steel I-beams subjected to fire and a combination of axial force and bending moments. A geometrical and material non-linear finite element program ... [more ▼]

This paper presents a numerical study of the behaviour of steel I-beams subjected to fire and a combination of axial force and bending moments. A geometrical and material non-linear finite element program, specially established in Liege for the analysis of structures submitted to fire, has been used to determine the resistance of a beam-column at elevated temperature, using the material properties of Eurocode 3, part 1-2. The numerical results have been compared with those obtained with the Eurocode 3, part 1-2 (1995) and the new version of the same Eurocode (2002). The results have confirmed that the new proposal for Eurocode 3 (2002) is more conservative than the ENV-EC3 (1995) approach. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

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See detailDesign of an implantable micropump
Smal, Olivier; Merken, Patrick; Croquet, Vincent et al

in Proceedings of the International Precision Assembly Seminar (2004, February)

The implantable programmable micropump is an interesting solution to treat chronic diseases such as diabetes with regular micro-injections of medicine. However, current applications of micropumps are ... [more ▼]

The implantable programmable micropump is an interesting solution to treat chronic diseases such as diabetes with regular micro-injections of medicine. However, current applications of micropumps are limited by their rather expensive cost. The challenge is therefore to develop a low cost alternative by reducing the number of parts and by simplifying the assembly. As the pump and its tank will be placed under the skin in order to increase comfort, such a system should be small and reliable. In this paper, we present the micropump we developed within the framework of the 4M-µ pump interuniversity project (Methods and Means for the Miniaturization of Machines). [less ▲]

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See detailNuclear bodies and compartmentalization of pre-mRNA splicing factors in higher plants
Docquier, Sarah; Tillemans, Vinciane ULg; Deltour, Roger et al

in Chromosoma (2004), 112(5), 255-266

We studied the fine structural organization of nuclear bodies in the root meristem during germination of maize and Arabidopsis thaliana using electron microscopy (EM). Cajal bodies (CBs) were observed in ... [more ▼]

We studied the fine structural organization of nuclear bodies in the root meristem during germination of maize and Arabidopsis thaliana using electron microscopy (EM). Cajal bodies (CBs) were observed in quiescent embryos as well as germinating cells in both species. The number and distribution of CBs were investigated. To characterize the nuclear splicing domains, immunofluorescence labelling with antibodies against splicing factors (U2B" and m3G-snRNAs) and in situ hybridisation (with U1/U6 antisense probes) were performed combined with confocal microscopy. Antibodies specific to the Arabidopsis SR splicing factor atRSp31 were produced. AtRSp31 was detected in quiescent nuclei and in germinating cells. This study revealed an unexpected nuclear speckled organization of atRSp31 in root epidermal cells where micro clusters of interchromatin granules were also observed by EM. Therefore, we examined the distribution of green fluorescent protein (GFP)-tagged atRSp31 in living cells after Agrobacterium-mediated transient expression. When expressed transiently, atRSp31-GFP exhibited a speckled distribution in leaf cells. Treatments with -amanitin, okadaic acid, staurosporine or heat-shock induced the speckles to reorganize. Furthermore, we have generated stable Arabidopsis transgenics expressing atRSp31-GFP. The distribution of the fusion protein was identical to the endogenous atRSp31. Three-dimensional time-lapse confocal microscopy showed that speckles were highly dynamic domains over time. [less ▲]

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See detailRegulation of HER-2 oncogene expression by cyclooxygenase-2 and prostaglandin E2
Benoit, Valérie; Relic, Biserka ULg; de Leval, Laurence ULg et al

in Oncogene (2004), 23(8), 1631-1635

The oncoprotein HER-2/neu is a prosurvival factor and its overexpression has been correlated with adverse prognosis in breast cancers. High levels of the cyclooxygenase-2 (COX-2), a proinflammatory and ... [more ▼]

The oncoprotein HER-2/neu is a prosurvival factor and its overexpression has been correlated with adverse prognosis in breast cancers. High levels of the cyclooxygenase-2 (COX-2), a proinflammatory and antiapoptotic enzyme, were detected in HER-2-positive tumors and this observation was linked to an HER-2-mediated induction of COX-2 gene transcription. Here, we report that COX-2 expression, and synthesis of its major enzymatic product, PGE2, leads in turn to an enhanced HER-2 expression. Moreover, COX-2 enzymatic inhibition dramatically reduced HER-2 protein levels, efficiently increased the cancer cells sensitility to chemotherapeutic treatment and acted in synergy with HER-2 inhibitor, trastuzumab. Therefore, we propose an original model where HER-2 and COX-2 transcriptionally regulate each other in a positive loop. [less ▲]

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See detailSome like it cold: biocatalysis at low temperatures
Georlette, D.; Blaise, Vinciane ULg; Collins, T. et al

in FEMS Microbiology Reviews (2004), 28(1), 25-42

In the last few years, increased attention has been focused on a class of organisms called psychrophiles. These organisms, hosts of permanently cold habitats, often display metabolic fluxes more or less ... [more ▼]

In the last few years, increased attention has been focused on a class of organisms called psychrophiles. These organisms, hosts of permanently cold habitats, often display metabolic fluxes more or less comparable to those exhibited by mesophilic organisms at moderate temperatures. Psychrophiles have evolved by producing, among other peculiarities, "cold-adapted" enzymes which have the properties to cope with the reduction of chemical reaction rates induced by low temperatures. Thermal compensation in these enzymes is reached, in most cases, through a high catalytic efficiency associated, however, with a low thermal stability. Thanks to recent advances provided by X-ray crystallography, structure modelling, protein engineering and biophysical studies, the adaptation strategies are beginning to be understood. The emerging picture suggests that psychrophilic enzymes are characterized by an improved flexibility of the structural components involved in the catalytic cycle, whereas other protein regions, if not implicated in catalysis, may be even more rigid than their mesophilic counterparts. Due to their attractive properties, i.e., a high specific activity and a low thermal stability, these enzymes constitute a tremendous potential for fundamental research and biotechnological applications. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved. [less ▲]

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See detailAnevrysmes mycotiques primaires de l'aorte sous-renale. A propos de deux cas
Rousie, Céline ULg; Van Damme, Hendrik ULg; Limet, Raymond ULg

in Revue Médicale de Liège (2004), 59(2), 89-94

Infrarenal mycotic aneurysms are rare. The classic symptomatic triad is abdominal pain, fever and a pulsatile, rapidly growing abdominal mass. We present two cases of mycotic abdominal aneurysm, recently ... [more ▼]

Infrarenal mycotic aneurysms are rare. The classic symptomatic triad is abdominal pain, fever and a pulsatile, rapidly growing abdominal mass. We present two cases of mycotic abdominal aneurysm, recently managed. The principles of diagnosis and treatment of mycotic aneurysm are reviewed and discussed. [less ▲]

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See detailBelgium's Undocumented Hold Lessons for EU
Martiniello, Marco ULg; Rea, Andrea

in Migration Information Source (2004)

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See detailMeer samen, beter toegankelijk. De maatschappelijke kracht van de sport verkend
Vincke, John; Cloes, Marc ULg

Book published by Koning Boudewijnstichting (2004)

This book aimed to propose policies designed to develop social links through sport and to improve the access to sport and physical activity.

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See detailLe cas clinique du mois. Cirrhose autoimmune traitee par transplantation hepatique 'a partir d'un lobe hepatique droit preleve chez un donneur vivant
Detry, Olivier ULg; De Roover, Arnaud ULg; Coimbra Marques, Carla ULg et al

in Revue Médicale de Liège (2004), 59(2), 69-74

The authors describe the case of a 17-year-old girl who suffered from end-stage liver failure due to chronic autoimmune hepatitis. Liver failure was complicated by severe portal hypertension ... [more ▼]

The authors describe the case of a 17-year-old girl who suffered from end-stage liver failure due to chronic autoimmune hepatitis. Liver failure was complicated by severe portal hypertension, hypersplenism and refractory ascites. Liver transplantation was indicated. She was listed for cadaveric whole liver transplantation, but her infrequent blood group (B) increased waiting time. Her condition deteriorated to Child C liver failure and living related liver transplant was considered. Her father was compatible and proposed himself for donation. Right lobe procurement was decided in order to provide sufficient liver mass. No transfusion of red cells, platelets, or fresh frozen plasma was used either in the donor or the recipient. Both recipient and donor left the ward at postoperative day 14, without complication. They were both asymptomatic and with normal liver tests at one year follow-up. Living related liver transplantation using the right lobe may offer an alternative to liver transplant candidates in this period of organ donor shortage. [less ▲]

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See detailAn educational simulation tool for power system control and stability
Vournas, Costas; Potamianakis, Emmanuel G.; Moors, Cédric et al

in IEEE Transactions on Power Systems (2004), 19(1), 48-55

This paper presents a Simulink-based educational tool developed for the purpose of illustrating power system control and stability notions as well as introducing students to realistic, though tractable in ... [more ▼]

This paper presents a Simulink-based educational tool developed for the purpose of illustrating power system control and stability notions as well as introducing students to realistic, though tractable in size, design problems. Relevant courses are taught to last-year undergraduate as well as graduate students at the University of, Liege, Belgium, and the National Technical University of Athens, Greece.. After a brief description of the corresponding curricula, the paper describes the simulation tool and gives examples of problems and assignments given to the students. [less ▲]

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See detailDesign and test of a circular notch hinge
Merken, Patrick; Smal, Olivier; Debongnie, Jean-François ULg et al

in Proceedings of the International Precision Assembly Seminar (2004, February)

At the microscale, classical bearings such as ball bearings, sliding bearings and other pivots may be difficult to manufacture. Among all possible solutions to replace them, the notch hing seems to be ... [more ▼]

At the microscale, classical bearings such as ball bearings, sliding bearings and other pivots may be difficult to manufacture. Among all possible solutions to replace them, the notch hing seems to be very attractive through its many advantages. The major limitation is on the rotation angle. This paper presents a new simplified analytical model for the prediction of the maximum angular displacement and the angular stiffness of a notch hinge. To validate our model, an experimental set-up has been developed. [less ▲]

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See detailMise au point d'une méthode de détermination in vitro du taux de fermentation des fibres dans le gros intestin du porc
Boudry, Christelle ULg; Buldgen, André; Anciaux, Benoit et al

in 36èmes Journées de la Recherche Porcine (2004, February)

L’objectif des études synthétisées dans cette communication consiste à mettre au point une méthode in vitro, simple, fiable et respectueuse du bien-être animal, pour mesurer la fermentation des fibres ... [more ▼]

L’objectif des études synthétisées dans cette communication consiste à mettre au point une méthode in vitro, simple, fiable et respectueuse du bien-être animal, pour mesurer la fermentation des fibres dans le gros intestin du porc. Les travaux ont été réalisés en adaptant la méthode de BOISEN et FERNANDEZ à la pepsine-pancréatine pour simuler la digestion des aliments dans la première partie du tube digestif. La méthode d’incubation en seringues de MENKE et STEINGASS a ensuite été utilisée pour quantifier la production de gaz des résidus de la prédigestion. Les expériences, réalisées au moyen de porcs en croissance, ont porté sur la quantité et le mode de filtration des substrats prédigérés par la pepsine-pancréatine, l’identification d’un aliment de référence, la dilution des inoculi dans la solution tampon en seringues et la comparaison des fermentations, en utilisant comme inoculi des contenus d’intestin ou des matières fécales. Les résultats montrent que la répétabilité de la digestion in vitro par la pepsine-pancréatine est satisfaisante et que les quantités d’aliment incubées peuvent être augmentées par rapport à la méthode de référence. La filtration des résidus peut être réalisée sur creusets filtrants ou sur toile Nylon. La pulpe de betterave constitue un aliment témoin idéal. Après 24 h d’incubation, la production de gaz obtenue à partir d’inoculi fécaux dilués 20 fois dans la solution tampon est identique à celle enregistrée à partir d’inoculi intestinaux dilués 10 fois dans le même tampon. [less ▲]

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See detailPower systems stability control: Reinforcement learning framework
Ernst, Damien ULg; Glavic, Mevludin; Wehenkel, Louis ULg

in IEEE Transactions on Power Systems (2004), 19(1), 427-435

In this paper, we explore how a computational approach to learning from interactions, called reinforcement learning (RL), can be applied to control power systems. We describe some challenges in power ... [more ▼]

In this paper, we explore how a computational approach to learning from interactions, called reinforcement learning (RL), can be applied to control power systems. We describe some challenges in power system control and discuss how some of those challenges could be met by using these RL methods. The difficulties associated with their application to control power systems are described and discussed as well as strategies that can be adopted to overcome them. Two reinforcement learning modes are considered: the online mode in which the interaction occurs with the real power system and the offline mode in which the interaction occurs with a simulation model of the real power system. We present two case studies made on a four-machine power system model. The first one concerns the design by means of RL algorithms used in offline mode of a dynamic brake controller. The second concerns RL methods used in online mode when applied to control a thyristor controlled series capacitor (TCSC) aimed to damp power system oscillations. [less ▲]

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See detailLearning movement patterns in mobile networks: a generic method
François, Jean-Marc; Leduc, Guy ULg; Martin, Sylvain ULg

in European Wireless 2004 (2004, February)

Predicting terminals movements in mobile networks is useful for more than one reason, in particular for routing management. A way to do such prediction is to learn the movement patterns of mobile nodes ... [more ▼]

Predicting terminals movements in mobile networks is useful for more than one reason, in particular for routing management. A way to do such prediction is to learn the movement patterns of mobile nodes passing by an access router. In this paper, the information (e.g. layer 2 measurements) related to the different paths followed by mobiles are learned using a hidden Markov model. Simulations have been done using this method and show it can handle different layer~2 signals and collect statistical information when no such signal is available. Furthermore, the method works when no information is available and can be extended so as to guess the timing of the handoffs. [less ▲]

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