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See detailDe l'interdisciplinarité. A propos du triptyque de la sainte Croix de Liège vers 1170)
George, Philippe ULiege

Scientific conference (2017, October 13)

Le triptyque mosan de la Sainte Croix de Liège (vers 1170), naguère encore conservé dans la collégiale éponyme de Liège, est bien connu des chercheurs. Des examens en laboratoire ont permis de ... [more ▼]

Le triptyque mosan de la Sainte Croix de Liège (vers 1170), naguère encore conservé dans la collégiale éponyme de Liège, est bien connu des chercheurs. Des examens en laboratoire ont permis de reconsidérer le dossier, déjà pourtant rouvert pour les Mélanges Marie-Madeleine Gauthier en 1996. Un aggiornamento sera fait après la publication des deux ouvrages sur L’œuvre de la Meuse (Liège, 2014 et 2016). L’intervention portera ensuite sur les émaux, à la suite de la précédente communication faite à Limoges en 2013 sur le Guennol-triptych contemporain. [less ▲]

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See detail1H, 13C and 15N backbone resonance assignments of the β-lactamase BlaP from Bacillus licheniformis 749/C and two mutational variants
Kay, Jennifer ULiege; Thorn, David; Rhazi, Noureddine ULiege et al

in Biomolecular NMR Assignments (2017)

Class A β-lactamases have been widely used as versatile scaffolds to create hybrid (or chimeric) proteins for a series of applications ranging from basic research to medicine. We have, in particular, used ... [more ▼]

Class A β-lactamases have been widely used as versatile scaffolds to create hybrid (or chimeric) proteins for a series of applications ranging from basic research to medicine. We have, in particular, used the β-lactamase BlaP from Bacillus licheniformis 749/C (BlaP) as a protein scaffold to create model polyglutamine (polyQ) proteins in order to better understand the mechanism(s) by which an expanded polyQ sequence triggers the formation of amyloid fibrils. The model chimeras were designed by inserting a polyQ sequence of various lengths at two different locations within BlaP (i.e. position 197 or position 216) allowing a detailed comparison of the effects of subtle differences in the environment of the polyQ sequence on its ability to trigger protein aggregation. In order to investigate the effects of the polyQ insertion at both positions on the structure, stability and dynamics of BlaP, a series of NMR experiments including H/D exchange are foreseen. Accordingly, as necessitated by these studies, here we report the NMR assignment of the wild-type BlaP (BlaP-WT) and of the two reference proteins BlaP197Q0 and BlaP216Q0, wherein a dipeptide Pro-Gly has been introduced at position 197 and 216, respectively; this dipeptide originates from the addition of the Sma1 restriction site at the genetic level to allow further polyQ sequence insertion. [less ▲]

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See detailThe Vacuum UV Photoabsorption Spectrum of the Geminal Dichloroethylene (1,1-C2H2Cl2) in the 5-20 eV Range. A Vibrational Analysis of the Valence and Rydberg States.
Locht, Robert ULiege; Dehareng, Dominique; Leyh, Bernard ULiege

in Journal of Physics Communications (2017), 1

The vacuum UV photoabsorption spectrum of 1,1-C2H2Cl2 is presented and discussed in detail in the 6 - 20 eV photon energy range. The broad band observed at 6.488 eV includes the 2b1()→σ*, 2b1()→ ... [more ▼]

The vacuum UV photoabsorption spectrum of 1,1-C2H2Cl2 is presented and discussed in detail in the 6 - 20 eV photon energy range. The broad band observed at 6.488 eV includes the 2b1()→σ*, 2b1()→* valence transitions and the 2b1()→3s Rydberg transitions. A quantum chemical calculation analysis is proposed and applied to the intertwined vibrational structure belonging to these transitions. For the →σ* and →* transitions short vibrational progressions are observed, analyzed and tentatively assigned. The →3s Rydberg transition is characterized by a single progression starting at 6.746 eV. The fine structure observed between 7.5 eV and 10.1 eV has been analyzed in terms of vibronic transitions to ns- (δ= 0.89), np- (δ= 0.59 and 0.37) and nd-type (δ= 0.16) Rydberg states all converging to the 1,1-C2H2Cl2+( 2B1) ionic ground state. The vibrational structure analysis excitation leads to the following wavenumbers: ω2≈ 1310 cm-1 (162 meV), ω4≈ 650 cm-1 (81 meV) and ω5≈ 290 cm-1 (37 meV). These modes can be assigned to the C=C stretching, to the symmetric C-Cl stretching and to the symmetric Cl-C-Cl bending vibrations respectively. By the same way, eight other Rydberg states were analyzed. For the first time the vacuum UV spectrum of 1,1-C2H2Cl2 has been recorded in the 10 eV-20 eV range, revealing intense broad bands which are assigned to transitions to Rydberg states converging to excited states of 1,1-C2H2Cl2+. Assignments are also proposed for the vibrational excitations observed in this range. [less ▲]

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See detailGround-based FTIR retrievals of SF6 at Réunion Island
Zhou, M.; Langerock, B.; Vigouroux, C. et al

in Atmospheric Measurement Techniques. Papers in Open Discussion (2017), 2017

SF6 total columns are successfully retrieved from FTIR measurements (Saint Denis and Maïdo) at Réunion Island (21 S, 55 E) between 2004-2016 using the SFIT4 algorithm: the retrieval strategy and the error ... [more ▼]

SF6 total columns are successfully retrieved from FTIR measurements (Saint Denis and Maïdo) at Réunion Island (21 S, 55 E) between 2004-2016 using the SFIT4 algorithm: the retrieval strategy and the error budget are presented. The FTIR SF6 retrieval has independent information in only one individual layer, covering the whole troposphere and the lower stratosphere. The trend of SF6 is analysed based on the FTIR retrieved dry air column-averaged mole fractions (XSF6 ) at Réunion Island, the in-situ measurements at America Samoa (SMO) and the collocated satellite measurements (MIPAS and ACE-FTS) in the southern tropics. The SF6 annual growth rate from FTIR retrievals is 0.265±0.013 pptv/year for 2004–2016, which is slightly weaker than that from the SMO in-situ measurements (0.285±0.002 pptv/year) for the same time period. The SF6 trend in the troposphere from MIPAS and ACE-FTS observations is also close to the ones from the FTIR retrievals and the SMO in-situ measurements. [less ▲]

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See detailImpact des pesticides et autres intrants illégaux et contrefaits sur l'économie du secteur horticole des pays ACP
Schiffers, Bruno ULiege

Conference given outside the academic context (2017)

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See detailAdvanced porosity-based models to assess the influence of urban layouts on inundation flows and impact of urban evolution on flood damage
Bruwier, Martin ULiege

Doctoral thesis (2017)

Worldwide, flood risk is expected to increase over the 21st century due to the combined effect of climate and land use changes. However, while the impact of climate change on future flood risk was ... [more ▼]

Worldwide, flood risk is expected to increase over the 21st century due to the combined effect of climate and land use changes. However, while the impact of climate change on future flood risk was extensively studied, the effects of urbanization remain unclear. The goal of this PhD thesis is to contribute to a better understanding of the influence of future urban development on changes in inundation flows as well as on the related damage. First, an original porosity-based model was developed, which enables efficient computation of urban flooding. It uses anisotropic porosity parameters to reproduce the influence of subgrid-scale obstacles on the flow. An original merging technique was implemented to optimize the computational efficiency in the presence of low values of the storage porosity parameter. Compared to a standard inundation model, the developed model enables speedup factors of the order of 100, while keeping the error on the flow variables at a few percent. Second, we systematically investigated how the layout of buildings located in floodplains influences the inundation characteristics for a long-duration flood scenario. The anisotropic porosity-based model was used to compute the flow variables for 2,000 alternative urban patterns. Correlations between the computed water depths and the urban characteristics reveal which features of the layout of buildings influences most the severity of urban flooding. In particular, the results suggest how the hydraulic effect of new urban development can be effectively mitigated by a suitable location of the buildings preserving a higher flow conveyance at the district-scale. This result provides guidance for more flood-proof urban developments. Finally, we evaluated the evolution of future flood damage as a result of urbanization along all the main rivers in the Walloon region, Belgium. The study was conducted at the regional level using detailed hydraulic results (resolution of 2 to 5 m). Despite high uncertainties in the considered urbanization scenarios, involving both urban expansion and densification, robust conclusions could be drawn, such as the overwhelming influence of banning new developments in flood-prone areas compared to the other tested facets of urban planning policy. [less ▲]

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See detailDusp3 deletion in mice promotes experimental lung tumour metastasis in a macrophage dependent manner
Vandereyken, Maud; Jacques, Sophie; Van Overmeire, Eva et al

in PLoS ONE (2017)

Vaccinia-H1 Related (VHR) dual-specificity phosphatase, or DUSP3, plays an important role in cell cycle regulation and its expression is altered in several human cancers. In mouse model, DUSP3 deletion ... [more ▼]

Vaccinia-H1 Related (VHR) dual-specificity phosphatase, or DUSP3, plays an important role in cell cycle regulation and its expression is altered in several human cancers. In mouse model, DUSP3 deletion prevents neo-angiogenesis and b-FGF-induced microvessel out- growth. Considering the importance of angiogenesis in metastasis formation, our study aimed to investigate the role of DUSP3 in tumour cell dissemination. Using a Lewis Lung carcinoma (LLC) experimental metastasis model, we observed that DUSP3-/- mice devel- oped larger lung metastases than littermate controls. DUSP3-/- bone marrow transfer to lethally irradiated DUSP3+/+ mice was sufficient to transfer the phenotype to DUSP3+/+ mice, indicating that hematopoietic cells compartment was involved in the increased tumour cell dissemination to lung tissues. Interestingly, we found a higher percentage of tumour- promoting Ly6Cint macrophages in DUSP3-/- LLC-bearing lung homogenates that was at least partially due to a better recruitment of these cells. This was confirmed by 1) the pres- ence of higher number of the Ly6Bhi macrophages in DUSP3-/- lung homogenates and by 2) the better migration of DUSP3-/- bone marrow sorted monocytes, peritoneal macrophages and bone marrow derived macrophages (BMDMs), compared to DUSP3+/+ monocytes, macrophages and BMDMs, in response to LLC-conditioned medium. Our study demon- strates that DUSP3 phosphatase plays a key role in metastatic growth through a mechanism involving the recruitment of macrophages towards LLC-bearing lungs. [less ▲]

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See detailLa remédiation numérique des savoirs critiques : enjeux formels et heuristiques
Provenzano, François ULiege; Lapointe, Olivier; Mayeur, Ingrid ULiege

Conference (2017, October 10)

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See detailOpen Geodata
Minet, Julien ULiege

Scientific conference (2017, October 10)

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See detailThe LNQ25 and ELN PVT Metrics Exhibit a Good Sensitivity to Sleep Deprivation and are Independent from the Subject
Latour, Philippe ULiege; Van Droogenbroeck, Marc ULiege

Poster (2017, October 09)

Introduction Performance of people undergoing critical tasks (like driving) may be impaired completely by the lowering of their vigilance level, due to sleep deprivation for instance. This reduction of ... [more ▼]

Introduction Performance of people undergoing critical tasks (like driving) may be impaired completely by the lowering of their vigilance level, due to sleep deprivation for instance. This reduction of performance may be measured by metrics computed from the reaction times (RT) recorded during a 10min Psychomotor Vigilance Test (PVT). Here, we analyze and compare the sensitivity to sleep deprivation and the subject dependent variability of the PVT metrics performance, with a special emphasis on the time interval sizes. Materials and Methods Individuals (22 volunteers; 11 males, 11 females, mean 22.2y., range 19-34 years) follow an uninterrupted 28h sleep deprivation standard PVT protocol during which they achieved two groups of three PVT sessions (in different conditions). The first PVT of each group is in Non-SDP condition (9h30 and 10h30 Day 1) and the second and third PVT of each group are in SDP condition (2h30, 3h30, 10h30 and 11h30 day 2). The subjects fill a sleep journal during the week before the experiment. We checked that they had a normal sleep-wake cycle with no sleep deprivation, jet-lag or shift work and no medication. During the PVT of the first group, the subjects were wearing the glasses of the Phasya’s Drowsimeter. We compute the usual PVT metrics; meanRT, meanRS (Reaction Speed) and LN500 (500ms lapses number). We also compute LNQ25 (adaptive lapses number computed with a subject dependent threshold) and ELN (Expected Lapse Number, computed from a subject-dependent estimation of the lapse probability). Results We use the “Effect Size” (ES, ratio of the mean by the standard deviation of the difference of metrics in the SDP and Non-SDP conditions) to assess the sensitivity to sleep deprivation. For the 10min (resp. 1min, 3min) interval, the ES of LNQ25 and ELN are respectively 1.38 (resp. 0.95, 1.22) and 1.35 (resp. 0.85, 1.14), the ES of meanRS, meanRT and LN500 are 1.23 (resp. 0.91, 1.09), 0.81 (resp. 0.54, 0.68) and 0.85 (resp. 0.63, 0.77). We classify the intervals on which metrics are computed as SDP or non-SDP. We use a fixed threshold for the metrics, independent of the subject. In the ROC curves, the TPR (for a FPR of 10%) assesses the quality of the classification, and then also the subject independence. For the 10min (resp. 1min, 3min) interval, the TPR of LNQ25 and ELN are respectively 0.86 (resp. 0.56, 0.75) and 0.83 (resp. 0.58, 0.75), the TPR of meanRS, meanRT and LN500 are 0.42 (resp. 0.38, 0.41), 0.40 (resp. 0.39, 0.40) and 0.42 (resp. 0.24, 0.30). Conclusions We demonstrate that LNQ25 and ELN enable a quite good classification of the SDP condition for time intervals greater than or equal to 3min, independently of the subject. On the other hand, these metrics provide also a good sensitivity to sleep deprivation. They outperform the usual metrics for both criteria. For time intervals below 3min, the performances degrade first progressively and then much more quickly below 1min. [less ▲]

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See detailPhysico-chemical Approach for Characterising Probiotics: example of High Concentrated Multistrain-Based Formulation
Razafindralambo, Hary ULiege; Delvigne, Frank ULiege; Blecker, Christophe ULiege

Poster (2017, October 09)

Probiotics are receiving today unprecedented growing interests in Europe, Asia, and in the rest of the world. Their applications are not only limited to food and health sectors, but cover also agriculture ... [more ▼]

Probiotics are receiving today unprecedented growing interests in Europe, Asia, and in the rest of the world. Their applications are not only limited to food and health sectors, but cover also agriculture and aquaculture areas. The quality of probiotic products depends on many factors such as, the properties of each individual strain and its proportion in mixed products, the viable probiotic dose, and other selective ingredients like prebiotics and protectant agents incorporated into the formulation. Several strategies are employed for ensuring high product qualities, which can be controlled by different methods and techniques. To date, the physico-chemical approach for characterizing and controlling probiotic qualities and performances appears very attractive, but less exploited. It particularly consists in characterizing probiotic products in terms of thermal, surface and colloidal properties, which could be correlated to probiotic viability and functionalities. In this communication, we report the efficiency of such an approach when applied to a high concentrated multistrain-based formulation which has been shown a metabolic variability impacting on the inflammatory response, depending on the production site. [less ▲]

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See detailSCENIC: single-cell regulatory network inference and clustering
Aibar, Sara; González-Blas, Carmen Bravo; Moerman, Thomas et al

in Nature Methods (2017), 14

We present SCENIC, a computational method for simultaneous gene regulatory network reconstruction and cell-state identification from single-cell RNA-seq data (http://scenic.aertslab.org). On a compendium ... [more ▼]

We present SCENIC, a computational method for simultaneous gene regulatory network reconstruction and cell-state identification from single-cell RNA-seq data (http://scenic.aertslab.org). On a compendium of single-cell data from tumors and brain, we demonstrate that cis-regulatory analysis can be exploited to guide the identification of transcription factors and cell states. SCENIC provides critical biological insights into the mechanisms driving cellular heterogeneity. [less ▲]

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See detailLe Grand Chemin du Luxembourg
Hurdebise, Quentin ULiege

Conference given outside the academic context (2017)

Dans le cadre des activités de l'Année Patrimoniale , le dimanche 8 octobre de 16h à 17h30 à l'église Saint-Jacques (Fossse), Quentin Hurdebise fait redécouvrir l'histoire du Grand Chemin du Luxembourg ... [more ▼]

Dans le cadre des activités de l'Année Patrimoniale , le dimanche 8 octobre de 16h à 17h30 à l'église Saint-Jacques (Fossse), Quentin Hurdebise fait redécouvrir l'histoire du Grand Chemin du Luxembourg connu notamment pour le transport des écorces de chênes qui l'empruntait en direction de Stavelot et de Malmedy. Quentin revient sur l'histoire de ce chemin, le contexte dans lequel il a pu naître, les différents noms qui lui sont attribués, ainsi que les différentes curiosités naturelles et historiques qui le jalonnent (faune et flore, maisons et personnages célèbres, croix et monuments, Observatoire Terrestre de Vielsalm, etc.). [less ▲]

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See detailRuminal function influenced by diet parameters in dairy herds with milk fat drop syndrome in Belgium
Knapp, Emilie ULiege; Sartelet, Arnaud ULiege; Malniece, Aija et al

Poster (2017, October 06)

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See detailTHIN-WALLED STEEL MEMBERS AT ELEVATED TEMPERATURES CONSIDERING LOCAL IMPERFECTIONS: NUMERICAL SIMULATION OF ISOLATED PLATES
Maraveas, Chrysanthos ULiege; Gernay, Thomas ULiege; Franssen, Jean-Marc ULiege

Scientific conference (2017, October 06)

The local buckling capacity of fire exposed thin-walled steel cross sections is affected by the reduction in strength and stiffness due to elevated temperatures and the amplitude of the initial local ... [more ▼]

The local buckling capacity of fire exposed thin-walled steel cross sections is affected by the reduction in strength and stiffness due to elevated temperatures and the amplitude of the initial local imperfections. A usual method to estimate this capacity is the simulation of isolated plates (web: four sides simply supported plate, flange: three sides simply supported plate) that are subjected to in-plane compression until instability is observed. Several researchers have proposed design methods to calculate the capacity of these steel members at elevated temperatures based on isolated plate analysis, but they used different methodologies. This variability in hypotheses happens because there is no clear provision defining the numerical modeling procedure for fire design of steel plates in the codes (European or US). The paper proposes a methodology for finite element simulation of thin plates at elevated temperatures and its governing factors (amplitude of initial local imperfections, number of half-wave geometry of local imperfections, plate geometry (sides ratio a/b)). [less ▲]

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See detail"Beaux livres" sur les jeux vidéo et presse vidéoludique : transferts et transformations du capital ludique
Dozo, Björn-Olav ULiege; Krywicki, Boris ULiege

Conference (2017, October 06)

Plusieurs auteurs l’ont souligné : la presse spécialisée en jeu vidéo contribue à bâtir la culture de ce médium (Zagal et Ladd, 2009 ; Nieborg et Sihvonen, 2009). Elle sert de vecteur de communication aux ... [more ▼]

Plusieurs auteurs l’ont souligné : la presse spécialisée en jeu vidéo contribue à bâtir la culture de ce médium (Zagal et Ladd, 2009 ; Nieborg et Sihvonen, 2009). Elle sert de vecteur de communication aux éditeurs, agrège les communautés de joueurs – déjà avec le courrier des lecteurs des magazines papier, a fortiori depuis l’arrivée des forums en ligne – et propose des référents aux lecteurs pour bâtir leurs goûts (genres de jeux, critères d’évaluation…). Parmi ces différentes fonctions, il faut souligner le rôle de passeur qu’occupent cette presse et ses journalistes. [less ▲]

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See detailA Combining Approach to Cover Song Identification
Osmalsky, Julien ULiege

Doctoral thesis (2017)

This thesis is concerned with the problem of determining whether two songs are different versions of each other. This problem is known as the problem of cover song identification, which is a challenging ... [more ▼]

This thesis is concerned with the problem of determining whether two songs are different versions of each other. This problem is known as the problem of cover song identification, which is a challenging task, as different versions of the same song can differ in terms of pitch, tempo, voicing, instrumentation, structure, etc. Our approach differs from existing methods, by considering as much information as possible to identify cover songs. More precisely, we consider audio features spanning multiple musical facets, such as the tempo, the duration, the harmonic progression, the musical structure, the relative evolution of timbre, among others. In order to do that, we evaluate several state-of-the-art systems on a common database, containing 12,856 songs, that is a subset of the Second Hand Song dataset. In addition to evaluating existing systems, we introduce our own methods, based on global features, and making use of supervised machine learning algorithms to build a similarity model. For evaluating and comparing the performance of 10 cover song identification systems, we propose a new intuitive evaluation space, based on the notions of pruning and loss. Our evaluation space allows to represent the performance of the selected systems in a two dimensional space. We further demonstrate that it is compatible with standard metrics, such as the mean rank, the mean reciprocal rank and the mean average precision. Using our evaluation space, we present a comparative analysis of 10 systems. The results show that few systems are usable in a commercial system, as the most efficient is able to identify a match at the first position for 39% of the analyzed queries, which corresponds to 4,965 songs. In addition, we evaluate the systems when they are pushed to their limits, by analyzing how they perform when the audio signal is strongly degraded. To improve the identification rate, we investigate ways of combining 10 systems. We evaluate rank aggregation methods, that aim at aggregating ordered lists of similarity results, to produce a new, better ordering of the database. We demonstrate that such methods produce improved results, especially for early pruning applications. In addition to evaluating rank aggregation techniques, we propose to study combination through probabilistic rules. As the 10 selected systems do not all produce probabilities of similarity, we investigate calibration techniques to map scores to relevant posterior probability estimates. After the calibration process, we evaluate several probabilistic rules, such as the product, the sum, and the median rule. We further demonstrate that a subset of the 10 initial systems produces better performance than the full set, thus showing that some systems are not relevant to the final combination. Applying a probabilistic product rule to a subset of systems significantly outperforms any individual systems, on the considered database. In terms of direct identification (top-1), we achieve an improvement of 10% (5,460 tracks identified), and in terms of mean rank, mean reciprocal rank and mean average precision, we respectively improve the performance by 40%, 9.5%, and 12.5%, with respect to the previous state-of-the-art performance. We further implement our final combination in a practical application, named DISCover, giving the possibility for a user to select a query and listen to the produced list of results. While a cover is not systematically identified, the produced list of songs is often musically similar to the query. [less ▲]

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See detailSome notions of compactness in Functional Analysis and one related question about diametral dimensions
Demeulenaere, Loïc ULiege

Scientific conference (2017, October 05)

The diametral dimension is a topological invariant on the class of topological vector spaces. Besides, there exists another diametral dimension which was claimed to be equal to the first one in Fréchet ... [more ▼]

The diametral dimension is a topological invariant on the class of topological vector spaces. Besides, there exists another diametral dimension which was claimed to be equal to the first one in Fréchet(-Schwartz) spaces. However, this equality has never been proved. In this talk, we make some reminders about Functional Analysis and some related concepts (seminorms, locally convex spaces, etc.) and we insist on some notions linked to compactness. We also introduce the associated notions of Montel spaces and Schwartz spaces. Then, we introduce the question about the equality of the two diametral dimensions and we explain why this is directly solved in non-Montel spaces and in Montel but not Schwartz spaces. Next, we describe some recent, positive, partial results in the context of Schwartz spaces. Finally, we explain what happens when we consider these diametral dimensions in non-metrizable locally convex spaces. [less ▲]

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See detailLa Belgique, son passé et son avenir
Verjans, Pierre ULiege

Conference given outside the academic context (2017)

L'histoire de la Belgique montre une zone entre l'Allemagne et la France, qui se développe d'un peu coup sur base d'une révolution nationale anti-néerlandaise et qui crée par contrecoup une identité ... [more ▼]

L'histoire de la Belgique montre une zone entre l'Allemagne et la France, qui se développe d'un peu coup sur base d'une révolution nationale anti-néerlandaise et qui crée par contrecoup une identité flamande forte. Cette identité flamande est traversée par des volontés indépendantistes récurrentes mais non dominantes. [less ▲]

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