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See detailBig Data and Geomatics - Towards a new paradigm in spatial information management
Kasprzyk, Jean-Paul ULiege; Hallot, Pierre ULiege

Conference (2017, November 17)

Big Data and Geomatics : towards a new paradigm in spatial information management During the last decade, the technological advances allowed a massive acquisition of digital data whose volume grows ... [more ▼]

Big Data and Geomatics : towards a new paradigm in spatial information management During the last decade, the technological advances allowed a massive acquisition of digital data whose volume grows exponentially. Going from location-based social networks to smartphones, users produce huge amounts of data that are located in space and time. The various exploitations of these large and heterogeneous datasets have created a new field called “Big Data”. As most of these data are characterized by spatial and temporal components, it has become the next challenge to handle for geomatics researchers within the next incoming year. In this presentation, we provide an overview of the main domains in geomatics that are impacted by big data. Related fields are among other things: terrestrial spatial data acquisition where the rise of powerful laser scanners, that can acquire millions of points per second in order to precisely represent built heritage in 3D, revolutionized topography; Global Navigation Satellite Systems (GNSS), powered by the European constellation Galileo, imply original researches able to increase the position accuracy of a simple smartphone user; remote sensing is now enriched by a wide open access capability thanks to Copernicus satellites which provide timely information for the management of the environment. In order to effectively manage and analyse information related to each of these revolutions, Geographical Information System (GIS) research uses innovative data storage strategies based on CityGML for 3D data, semantic web linked-data and non-structured databases (NoSQL) for the integration of heterogeneous information, data warehouses and OnLine Analytical Processing (OLAP) for decision support. The presentation is based on concrete applications about smart cities, remote sensing, firefighting… [less ▲]

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See detailFirm Performance and Multi-Scale Territorial Resources in Wallonia: Towards a Model using Business Accounting?
Wilmotte, Pierre-François ULiege; Halleux, Jean-Marie ULiege

Poster (2017, November 17)

In Europe (and in Wallonia), most public policies related to regional development and economic development aim to stimulate/reinforce the ‘’territorial resources’’ in order to improve the competitiveness ... [more ▼]

In Europe (and in Wallonia), most public policies related to regional development and economic development aim to stimulate/reinforce the ‘’territorial resources’’ in order to improve the competitiveness of the (Walloon, Belgian or European) firms. For instance, in Wallonia, one of the key action of the Marshall Plan (i.e. the main regional strategy in the domain of economic development) aims to “mobilize the territory” (in French, « mobilisation du territoire à destination du développement économique »). In this perspective, our objective is to quantify and analyse the territorial resources that impact the performance of Walloon or Belgian firms, with the final aim to advice the policy makers and to improve the related public policies. This topic is related to questions such as: Does a better accessibility of economic estates improve the performance of firms? Are cultural amenities (in order to attract talents) and land prices (in order to reduce their costs) strategic competitive advantages for firms? The poster describes some methodological issues of (in general) the PhD research and (particularly) one part of the research, concerning a multivariate statistics analysis of business accounting. [less ▲]

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See detailUsage des boîtiers de vote électronique et développement professionnel de l’enseignant-universitaire
Detroz, Pascal ULiege; Younes, Nathalie

Conference (2017, November 16)

Les boitiers de vote font l’objet de très nombreux articles. Les auteurs cherchent par exemple à voir si l’utilisation de cet outil a un effet sur la motivation des étudiants et leur participation au ... [more ▼]

Les boitiers de vote font l’objet de très nombreux articles. Les auteurs cherchent par exemple à voir si l’utilisation de cet outil a un effet sur la motivation des étudiants et leur participation au cours (Caldwell, 2007), sur leur engagement (Mc Gowan et Gunderson,2010), sur le climat de classe (Bain et Przybyla, 2009) ou encore sur les apprentissages qu’ils réalisent (Preszler et al., 2007). Au final, comme souvent lorsqu’il s’agit de technologie, il semble que ce soit la pédagogie supportée par l’outil qui fasse la différence : l’usage sera pertinent s’il entre en résonance et en concordance avec une pédagogie efficace. Certes, l’outil en lui-même peut avoir un effet sur la pédagogie. Influencer, de par son fonctionnement - les possibilités qu’il offre, parfois les contraintes qu’il fait peser - la manière de concevoir des dispositifs pédagogiques. Il peut ainsi modifier le rapport des enseignants à leur pédagogie, c’est-à-dire, finalement, stimuler ou catalyser le développement professionnel des enseignants dans le domaine de la pédagogie universitaire. L’effet de l’outil et de son usage sur ce développement professionnel est au cœur de notre article. En effet, nous avons greffé - sur deux dispositifs d’accompagnement technopédagogique d’enseignants novices dans le domaine des BVE - un dispositif de recherche observant l’effet de cet usage accompagné. L’un de ces dispositifs d’accompagnement était court : l’enseignant est interviewé à deux reprises et observé lors d’une séance de cours durant laquelle les BVE sont utilisés. L’autre est plus long et comprend des autoconfrontations, des interviews, le recueil de l’avis des étudiants… La méthodologie utilisée dans cette étude, de type qualitatif, confirme notre intuition de départ : l’usage accompagné de BVE chez des enseignants novices peut, sous certaines conditions dont nous ferons état lors de la communication, accélérer le développement professionnel de ces derniers. [less ▲]

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See detailCarte interactomique entre l'oncoprotéine Tax du virus HTLV-1 et les protéines à domaines PDZ.
Blibek, Karim ULiege

Doctoral thesis (2017)

HTLV-1 (Human T-cell Leukemia Virus) is the etiologic agent of human adult T-cell leukemia (ATL) and tropical spastic paraparesis (TSP). More than 20 million people worldwide are infected with the HTLV-1 ... [more ▼]

HTLV-1 (Human T-cell Leukemia Virus) is the etiologic agent of human adult T-cell leukemia (ATL) and tropical spastic paraparesis (TSP). More than 20 million people worldwide are infected with the HTLV-1 virus, but only about 5 % develop the associated pathologies. At present, efforts are invested in the search for treatments that may improve the survival expectancy of patients infected by the HTLV-1 virus. The diagnosis of HTLV-1 infection is hampered by the viral genome latency (up to 40 years) and treatment options are limited. To propose novel therapeutic opportunities, it thus is necessary to better understand the host molecular mechanisms perturbed by the HTLV-1 infection. The HTLV-1 genome encodes for the Tax-1 protein, which confers the transforming ability of the virus. The Tax-1 protein is known as the transactivator factor of the HTLV-1 virus genome expression (TransActivator of pX region). It is also involved in the destabilization of several molecular mechanisms within the host, leading to cellular transformation. Tax-1 protein displays several functional domains and interacts with a wide range of cellular proteins. In particular, the Tax-1 protein sequence contains, at its carboxy-terminal end, a motif of four amino acids able to interact with PDZ domain (PSD95-DLG1-ZO1) containing proteins. It has been demonstrated that deletion of the PDZ binding motif (PBM) of the Tax-1 protein leads to a decrease of its oncogenic capacity in vitro. Cellular proteins containing PDZ domains are involved in the formation of cellular junctions, synapses and in cellular receptors assembly. Some of PDZ proteins are capable of relaying extracellular signals and participate in the control of proliferation. The human genome codes for at least 150 proteins with PDZ domains. However, the specificity of the oncoprotein Tax-1 to target these proteins remains unknown. In this study, we have mapped The Tax-1 - PDZ interactome using a combination of several methods. We reveal that Tax-1 selectively target a number of PDZ domains-containing proteins potentially involved in HTLV-1 pathogenesis. We validated our approach by focusing on the role of SDCBP and LNX2 proteins in HTLV-1 biology. Our work also demonstrated that the Tax-1-PDZ interactome might represent an attractive therapeutic target for HTLV-1-induced diseases. [less ▲]

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See detailPratiques d’évaluation des acquis, ancienneté et attitudes face à l’évaluation
Romainville, Marc; Detroz, Pascal ULiege; Auquière, Amélie ULiege et al

Conference (2017, November 16)

La présente communication est issue d’une recherche plus globale visant à identifier et à mieux comprendre les pratiques d’évaluation des acquis des étudiants auxquelles recourent les enseignants de ... [more ▼]

La présente communication est issue d’une recherche plus globale visant à identifier et à mieux comprendre les pratiques d’évaluation des acquis des étudiants auxquelles recourent les enseignants de l’enseignement supérieur et en particulier les facteurs personnels (ancienneté, attitudes vis-à-vis de l’évaluation…) et contextuels (année d’étude, taille du groupe, disciplines…) qui influencent ces pratiques. Les données ont été recueillies en 2016, d’une part, via une enquête en ligne (élaborée à l’aide du logiciel d’enquêtes Qualtrics) auprès d’enseignants de l’enseignement supérieur belge francophone que ce soit à l’Université ou en Hautes écoles (2292 réponses) et, d’autre part, via 37 entretiens semi-structurés individuels réalisés auprès d’un échantillon de ces mêmes enseignants dans des filières d’études contrastées. Les résultats présentés dans le cadre de cette communication ont trait à l’impact de deux variables personnelles : l’ancienneté des enseignants et leurs attitudes vis-à-vis de l’évaluation. Autrement dit, on cherchera à savoir si l’ancienneté et le développement professionnel qui l’accompagne traditionnellement ont des incidences sur le type de pratiques d’évaluation des acquis des enseignants. En particulier, recourent-ils à des outils de plus en plus diversifiés ou ont-ils tendance à se spécialiser dans l’un ou l’autre ? Et si oui, pourquoi ? Accentuent-ils par ailleurs le recours à l’évaluation continue par rapport au poids du contrôle terminal ? On cherchera ensuite à comprendre comment les pratiques se reconfigurent en fonction des attitudes des enseignants vis-à-vis de l’évaluation et en particulier vis-à-vis de sa fonction et de son rapport à l’apprentissage : dans quel sens une conception davantage intégrative de l’évaluation colore-t-elle les pratiques déclarées d’évaluation ? [less ▲]

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See detailCarte interactomique entre l'oncoprotéine Tax du virus HTLV-1 et les protéines à domaines PDZ.
Blibek, Karim ULiege

Scientific conference (2017, November 16)

ABSTRACT HTLV-1 (Human T-cell Leukemia Virus) is the etiologic agent of human adult T-cell leukemia (ATL) and tropical spastic paraparesis (TSP). More than 20 million people worldwide are infected with ... [more ▼]

ABSTRACT HTLV-1 (Human T-cell Leukemia Virus) is the etiologic agent of human adult T-cell leukemia (ATL) and tropical spastic paraparesis (TSP). More than 20 million people worldwide are infected with the HTLV-1 virus, but only about 5 % develop the associated pathologies. At present, efforts are invested in the search for treatments that may improve the survival expectancy of patients infected by the HTLV-1 virus. The diagnosis of HTLV-1 infection is hampered by the viral genome latency (up to 40 years) and treatment options are limited. To propose novel therapeutic opportunities, it thus is necessary to better understand the host molecular mechanisms perturbed by the HTLV-1 infection. The HTLV-1 genome encodes for the Tax-1 protein, which confers the transforming ability of the virus. The Tax-1 protein is known as the transactivator factor of the HTLV-1 virus genome expression (TransActivator of pX region). It is also involved in the destabilization of several molecular mechanisms within the host, leading to cellular transformation. Tax-1 protein displays several functional domains and interacts with a wide range of cellular proteins. In particular, the Tax-1 protein sequence contains, at its carboxy-terminal end, a motif of four amino acids able to interact with PDZ domain (PSD95-DLG1-ZO1) containing proteins. It has been demonstrated that deletion of the PDZ binding motif (PBM) of the Tax-1 protein leads to a decrease of its oncogenic capacity in vitro. Cellular proteins containing PDZ domains are involved in the formation of cellular junctions, synapses and in cellular receptors assembly. Some of PDZ proteins are capable of relaying extracellular signals and participate in the control of proliferation. The human genome codes for at least 150 proteins with PDZ domains. However, the specificity of the oncoprotein Tax-1 to target these proteins remains unknown. In this study, we have mapped The Tax-1 - PDZ interactome using a combination of several methods. We reveal that Tax-1 selectively target a number of PDZ domains-containing proteins potentially involved in HTLV-1 pathogenesis. We validated our approach by focusing on the role of SDCBP and LNX2 proteins in HTLV-1 biology. Our work also demonstrated that the Tax-1-PDZ interactome might represent an attractive therapeutic target for HTLV-1-induced diseases. KEYWORDS: HTLV-1, Leukemia, Tax-1, interactions, PDZ. [less ▲]

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See detailTowards a Typology of Business Models in the Biotechnology Industry
Segers, Jean Pierre ULiege

E-print/Working paper (2017)

The purpose of this paper is to identify a selection of key business models - “typology” - applied in the biotechnology industry. The focus is on the differences between traditional/closed or stand-alone ... [more ▼]

The purpose of this paper is to identify a selection of key business models - “typology” - applied in the biotechnology industry. The focus is on the differences between traditional/closed or stand-alone business models opposed to open or networked business models. A number of illustrative case studies and good practices are presented to show that new biotechnology firms are gradually adopting a “best of both worlds” strategy, with both closed business models and open, networked models as a way for gaining access to the market, in close collaboration with large global pharmaceutical companies. The case firms and good practices are taken from a recent country study for Belgium. [less ▲]

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See detailL'Europe est-elle plus verte ?
Habran, Maxime ULiege

Conference given outside the academic context (2017)

Bilan de la politique environnementale et de la lutte contre le changement climatique au sein des politiques européennes

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See detailOverview and future challenges of nearly Zero Energy Buildings (nZEB) design in Southern Europe
Attia, Shady ULiege; Polyvios, Eleftheriou; Xeni, Flouris et al

in Energy and Buildings (2017), 155

In times of great transition of the European construction sector to energy efficient and nearly zero energy buildings (nZEB), a market observation containing qualitative and quantitative indications ... [more ▼]

In times of great transition of the European construction sector to energy efficient and nearly zero energy buildings (nZEB), a market observation containing qualitative and quantitative indications should help to fill out some of the current gaps concerning the EU 2020 carbon targets. Next to the economic challenges, there are equally important factors that hinder renovating the existing residential building stock and adding newly constructed high performance buildings. Under these circumstances this paper summarises the findings of a cross-comparative study of the societal and technical barriers of nZEB implementation in 7 Southern European countries. The study analyses the present situation and provides an overview on future prospects for nZEB in Southern Europe. The result presents an overview of challenges and provides recommendations based on available empirical evidence to further lower those barriers in the European construction sector. The paper finds that the most Southern European countries are poorly prepared for nZEB implementation and especially to the challenge/opportunity of retrofitting existing buildings. Creating a common approach to further develop nZEB targets, concepts and definitions in synergy with the climatic, societal and technical state of progress in Southern Europe is essential. The paper provides recommendations for actions to shift the identified gaps into opportunities for future development of climate adaptive high performance buildings. [less ▲]

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See detailCaractérisation ontogénique, phénotypique et fonctionnelle des macrophages interstitiels pulmonaires après exposition à des composés bactériens
Sabatel, Catherine ULiege

Doctoral thesis (2017)

Respiratory mucosal surfaces are continuously exposed to harmless antigens and immunostimulatory molecules of microbial origin. According to the « self/non self » and « danger » theories, this should ... [more ▼]

Respiratory mucosal surfaces are continuously exposed to harmless antigens and immunostimulatory molecules of microbial origin. According to the « self/non self » and « danger » theories, this should normally result in the developpment of unwanted immune responses towards these inhaled antigens such as Th2-mediated allergic responses. This is however not the case in most people. The hygiene hypothesis postulates that living in an environment rich in microbial components paradoxically protects from airway allergy, implying the existence in the lung of suppressive mechanisms triggered by these immunogenic signals. In this study, we showed that synthetic bacterial DNA rich in unmethylated CpG motifs (CpG) has the unique ability to significantly increase the population of lung interstitial regulatory macrophages (IM) from CCR2-independent monocytes residing in the lung or mobilized from the spleen. Moreover these CpG-induced IM demonstrated a hypersuppressive profile as they produced more IL-10 than their steady state counterparts. Using mice models of airway allergy we showed that the transfert of IM isolated from CpG-treated mice recapitulated the protective effects of CpG when administered before allergen sensitization or challenge. This IM-mediated protection was dependant from IL-10 as CpG-induced Il10-/- IM had no protective effect. The expansion of pulmonary regulatory IM from CCR2-independent pulmonary and splenic monocytes upon CpG exposure could be a possible mechanism by which exposure to an environment rich in microbial products protects against asthma. [less ▲]

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See detailQuels futurs pour la fabrication de pièces métalliques ?
Habraken, Anne ULiege; Delvenne, Pierre ULiege; Elsen, Catherine ULiege

Conference given outside the academic context (2017)

Les processus de fabrication des pièces métalliques sont au cœur de nombreux enjeux technologiques, sociopolitiques et économiques. Ces dernières années, des procédés tels le 3D Printing ou encore le ... [more ▼]

Les processus de fabrication des pièces métalliques sont au cœur de nombreux enjeux technologiques, sociopolitiques et économiques. Ces dernières années, des procédés tels le 3D Printing ou encore le formage incrémental ont apporté un renouveau possible face aux méthodes de fabrication traditionnelles. Si le premier est, à présent, bien connu du grand public, le formage incrémental mérite encore quelques explications. Ce procédé, relativement lent, est de mieux en mieux maîtrisé. Il permet de réaliser des pièces métalliques aussi diverses qu’une prothèse, un panneau de façade ou de porte de boeing, un évier de cuisine, ... Il comporte de multiples variantes et est progressivement exploité par l’industrie pour du prototypage de pièces uniques et des petites séries. A l’ère de la révolution numérique, où les Fablabs, Repair Cafés et autres Hackers Labs permettent aux citoyens de créer leurs propres pièces et de devenir acteurs de l’innovation, ce procédé ouvre ainsi de nouvelles portes pour la conception de pièces métalliques. [less ▲]

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See detailOut of hospital neonatal resuscitation: a control randomised study
Servotte, Jean-Christophe ULiege; Ghuysen, Alexandre ULiege; Simonet et al

Conference (2017, November 14)

Introduction : En 2014, 64 accouchements inopinés sont survenus en Wallonie. 5,3% des naissances ont nécessité une réanimation néonatale. Or, de nombreux professionnels de l’urgence terminent leur ... [more ▼]

Introduction : En 2014, 64 accouchements inopinés sont survenus en Wallonie. 5,3% des naissances ont nécessité une réanimation néonatale. Or, de nombreux professionnels de l’urgence terminent leur formation avec une expertise insuffisante dans ce domaine (Nadel et al. 2000). En effet, la réanimation néonatale nécessite des compétences cognitives, techniques et comportementales spécifiques (Halamek et al. 2016). Objectifs : Notre étude randomisée contrôlée a évalué l’impact d’une formation utilisant la simulation clinique sur l’évolution des connaissances et des compétences techniques en réanimation néonatale, avec l’hypothèse que cette méthode a un impact supérieur à l’enseignement clinique traditionnel. Matériel & Méthodes : Des infirmiers se spécialisant en soins intensifs et aide médicale urgente (SIAMU) ont été assignés, après randomisation, à un groupe expérimental (GE) ou à un groupe contrôle (GC). Le GE a reçu un cours théorique suivi d’une formation par simulation (2h) et de 4 semaines de stage. Le GC a reçu un cours théorique suivi de 4 semaines de stage. La population a été évaluée à 2 reprises au moyen d’une simulation de réanimation néonatale et de questionnaires: avant et après la formation, à 4 semaines d’intervalle. Deux experts ont évalué à l’aveugle sur base d’une grille critériée les compétences techniques lors de la simulation. Résultats : 36 participants ont été inclus dans l’étude. Les 2 groupes ont amélioré leurs connaissances. Comparativement, le GE a davantage amélioré ses connaissances globales (p = 0,0001) et spécifiques (p = 0,0007). La formation a permis une amélioration des compétences techniques de 83,3% pour le GC et de 175% pour le GE. Cette différence est significative (p = 0,003). Conclusions : Les deux méthodes pédagogiques ont amélioré les connaissances et les compétences techniques des infirmiers SIAMU. Toutefois, l’impact est significativement supérieur en faveur de la formation utilisant la simulation par rapport à l’enseignement clinique traditionnel. [less ▲]

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See detailThe Vacuum UV Photoabsorption Spectrum of the Geminal Dichloroethylene (1,1-C2H2Cl2) in the 5-20 eV Range. A Vibrational Analysis of the Valence and Rydberg States.
Locht, Robert ULiege; Dehareng, Dominique; Leyh, Bernard ULiege

in Journal of Physics Communications (2017), 1(04), 5013

The vacuum UV photoabsorption spectrum of 1,1-C2H2Cl2 is presented and discussed in detail in the 6 - 20 eV photon energy range. The broad band observed at 6.488 eV includes the 2b1()→σ*, 2b1()→ ... [more ▼]

The vacuum UV photoabsorption spectrum of 1,1-C2H2Cl2 is presented and discussed in detail in the 6 - 20 eV photon energy range. The broad band observed at 6.488 eV includes the 2b1()→σ*, 2b1()→* valence transitions and the 2b1()→3s Rydberg transitions. A quantum chemical calculation analysis is proposed and applied to the intertwined vibrational structure belonging to these transitions. For the →σ* and →* transitions short vibrational progressions are observed, analyzed and tentatively assigned. The →3s Rydberg transition is characterized by a single progression starting at 6.746 eV. The fine structure observed between 7.5 eV and 10.1 eV has been analyzed in terms of vibronic transitions to ns- (δ= 0.89), np- (δ= 0.59 and 0.37) and nd-type (δ= 0.16) Rydberg states all converging to the 1,1-C2H2Cl2+( 2B1) ionic ground state. The vibrational structure analysis excitation leads to the following wavenumbers: ω2≈ 1310 cm-1 (162 meV), ω4≈ 650 cm-1 (81 meV) and ω5≈ 290 cm-1 (37 meV). These modes can be assigned to the C=C stretching, to the symmetric C-Cl stretching and to the symmetric Cl-C-Cl bending vibrations respectively. By the same way, eight other Rydberg states were analyzed. For the first time the vacuum UV spectrum of 1,1-C2H2Cl2 has been recorded in the 10 eV-20 eV range, revealing intense broad bands which are assigned to transitions to Rydberg states converging to excited states of 1,1-C2H2Cl2+. Assignments are also proposed for the vibrational excitations observed in this range. [less ▲]

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See detailAnomalies des gonadorophines LH et FSH: tableaux cliniques
VALDES SOCIN, Hernan Gonzalo ULiege

Scientific conference (2017, November 14)

L’hormone lutéinisante (LH) et l’hormone folliculostimulante (FSH) – hormones glycoprotéiques hypophysaires – régulent de concert la production de stéroïdes sexuels et la reproduction. Les stéroïdes ... [more ▼]

L’hormone lutéinisante (LH) et l’hormone folliculostimulante (FSH) – hormones glycoprotéiques hypophysaires – régulent de concert la production de stéroïdes sexuels et la reproduction. Les stéroïdes sexuels sont indispensables à la virilisation et à la féminisation, et participent également à la gamétogenèse (spermatogenèse chez l’homme et folliculogenèse chez la femme). Cette présentation fait le point sur la physiologie et la pathologie de LH et de FSH en reproduction humaine. [less ▲]

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See detailTechniques d'ENMG (Second Master Médecine)
WANG, François-Charles ULiege

Learning material (2017)

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See detailEtude de la transmission du gammaherpèsvirus murin 4: importance de la glycoprotéine gp150 et développement de stratégies antivirales basées sur l'utilisation du cidofovir
Zeippen, Caroline ULiege

Doctoral thesis (2017)

Gammaherpèsviruses are important pathogens in human medicine. Indeed, Epstein Barr virus and Kaposi Sarcoma associated herpesvirus are responsible for numerous lymphoproliferative diseases and cancers ... [more ▼]

Gammaherpèsviruses are important pathogens in human medicine. Indeed, Epstein Barr virus and Kaposi Sarcoma associated herpesvirus are responsible for numerous lymphoproliferative diseases and cancers. Murid Herpesvirus-4 (MuHV-4) is usually used as a model for human gammaherpèsviruses. Until now, the major limitation of this model was the absence of transmission in laboratory animals. Recently, a sexual transmission of MuHV-4 has been described in laboratory mice. This observation allows, on the one hand, to study mechanisms underlying natural transmission, such as cellular trospism, importance of viral proteins, or immunity response during this part of the cycle. On the other hand, this transmission model allows to test efficiency of measures to reduce transmission. Indeed, herpesvirus are archetype of persistant viruses as infection persists lifelong once established. Studying mechanisms underlying transmission and how to use these mechanisms to reduce it efficiently is therefore of primordial importance. In a first study, we focussed on the biological relevance of mechanisms described previously in vitro. Indeed, a MuHV-4 glycoprotein, gp150, has been shown to participate to the release of infectious particles from cells and to evasion of humoral immunity, two functions that could be important for the virus during transmission. Our results showed that gp150 is essential for an efficient sexual transmission of the MuHV-4. Indeed, gp150 promotes the release of infectious particles from infected vaginal epithelial cells. These results has been published in Journal of Virology in July 2017. In a second study, the same model was used to test efficiency of an antiviral molecule to reduce sexual transmission of the MuHV-4. A nucleotide analogue, the cidofovir, was administrated to mice according to different protocols. A daily administration of cidofovir reduced drastically genital shedding, but also prevent completely infection of naive mice after sexual contact. Finally, a single injection of cidofovir, administered 24 hours after sexual contact, reduced significantly transmission. Altogether, in this work, we used a transmission model of a gammaherpèsvirus in two differents studies: the first foccused on glycoprotein implicated during the transmission and established the importance of a single viral glycoprotein for an efficient transmission. The second study highlighted the efficiency of antiviral drugs to prevent infection by gammaherpesviruses. [less ▲]

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See detailThe Physiology of The Thymus
Geenen, Vincent ULiege

Scientific conference (2017, November 13)

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See detailL'économie collaborative
Gautier, Axel ULiege

Conference given outside the academic context (2017)

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See detailElastic scattering, total cross sections and 𝝆 parameters at the LHC
Cudell, Jean-René ULiege

Speech/Talk (2017)

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