Publications ORBi OA
Bookmark and Share    
Full Text
See detailRole of estradiol in the feminization of lordosis behavior
Trouillet, Anne-Charlotte ULg

Poster (2014, September)

The classic theory of mammalian brain and behavioral sexual differentiation holds that an organizational action of testosterone, secreted perinatally by the male’s testes, controls male-typical aspects of ... [more ▼]

The classic theory of mammalian brain and behavioral sexual differentiation holds that an organizational action of testosterone, secreted perinatally by the male’s testes, controls male-typical aspects of brain and behavioral development, whereas no active perinatal sex hormone signaling is required for female-typical differentiation. However, it has recently been shown using aromatase knock out (ArKO) mice, which are deprived of estradiol due to a targeted mutation in the aromatase gene, that estradiol may also actively contribute to the differentiation of female-typical aspects of behavior over a specific pre-pubertal period. Sexual behavior is a well known sexually dimorphic behavior, and thus provides a good model for studying the sexual differentiation of the brain. Female ArKO mice showed significantly lower levels of lordosis behavior than wild type controls following adult ovariectomy and treatment with ovarian hormones. This deficit was restored by treating female ArKO mice with estradiol benzoate between postnatal days 15 and 25. However, the mechanism by which estradiol acts prepubertally in female mice to feminize lordosis behavior remains to be elucidated. Therefore, in a first attempt, we will determine which neuropeptides are in particularly sensitive to estradiol action over the prepubertal period. We will focus on neuropeptides which have been shown to be implicated in lordosis behavior. Studies by the group of Micevych have proposed an important role for NPY and beta-endorphin (B-END) neurons in the arcuate nucleus (ARC) in the estradiol-mediated activation of lordosis behavior in female rats. An in vitro study recently showed that kisspeptin directly activates arcuate (ARC) B-END neurons. This is particularly interesting since unpublished results from our laboratory showed that Kp neurons are directly involved in the expression of lordosis behavior. We are thus currently determining the expression of NPY, B-END, and kisspeptin in the ARC as well as μ-opioid receptors MORs in the MPN over the prepubertal period and their possible modulation by prepubertal estradiol treatment. Interestingly, we also observed that our treatment may have an organizational effect on the regulation of energy balance. Indeed, administration of estradiol over the prepubertal period restores a normal weight in ArKO mice, which are normally obese in adulthood. It has been shown that ArKO mice present a lower spontaneous physical activity which can be one cause of their obesity. However, our treated mice did not show an increase in their locomotion behavior. These new observations suggest that estradiol during prepubertal development may have an additional role in the organization of brain circuits regulating the energy balance. [less ▲]

Detailed reference viewed: 7 (1 ULg)
Full Text
See detailSTARS of HEAVEN - interview ( Chicago, Juin 2014)
Sacré, Robert ULg

in ABS Magazine (2014), (n° 43), 28-32

Interview des membres des Stars of Heaven ; photos

Detailed reference viewed: 8 (2 ULg)
Full Text
Peer Reviewed
See detailAutonomie de la volonté et concurrence régulatoire – le cas des relations familiales internationales
Wautelet, Patrick ULg

in Fulchiron, Hugues; Bergé, Jean-Sylvestre (Eds.) Vers un statut européen de la famille ? (2014)

L'autonomie de la volonté a connu un essor considérable dans le règlement des relations familiales internationales. Au-delà de la consécration toujours plus importante de l'autonomie de la volonté comme ... [more ▼]

L'autonomie de la volonté a connu un essor considérable dans le règlement des relations familiales internationales. Au-delà de la consécration toujours plus importante de l'autonomie de la volonté comme fondement de la règle de conflit de lois en matière familiale, la liberté des parties a reçu ces dernières années un appui important par le biais d'une jurisprudence ambitieuse tant de la Cour de justice de l'Union que de la Cour européenne des droits de l'homme. Dans le même temps, force est bien de constater que le droit de la famille semble constituer un îlot de résistance tenace face au mouvement d'unification et d'harmonisation. Les ingrédients semblent dès lors réunis pour le développement d'une véritable concurrence législative qui pourrait mener au spectre de la 'race to the bottom'. A l'offre de droits aux contenus différents se conjuge en effet une certaine possibilité de choix par les parties. Cette liberté de choix constitue un avatar évident de la mobilité qui fonde le pouvoir d'arbitrage des acteurs privés. La présente contribution a pour objectif de s'interroger sur l'existence réelle d'une telle concurrence normative. [less ▲]

Detailed reference viewed: 26 (1 ULg)
Full Text
Peer Reviewed
See detailMathematical modeling of HIV dynamics after antiretroviral therapy initiation: A clinical research study
Moog, Claude; Rivadeneira, Pablo; Stan, Guy-Bart et al

in AIDS Research and Human Retroviruses (2014), 30(9), 831-834

Immunological failure is identified from the estimation of certain parameters of a mathematical model of the HIV infection dynamics. This identification is supported by clinical research results from an ... [more ▼]

Immunological failure is identified from the estimation of certain parameters of a mathematical model of the HIV infection dynamics. This identification is supported by clinical research results from an original clinical trial. Standard clinical data were collected from infected patients starting Highly Active Anti-Retroviral Therapy (HAART), just after one month following therapy initiation and were used to carry out the model identification. The early diagnosis is shown to be consistent with the patients monitoring after six months. [less ▲]

Detailed reference viewed: 19 (1 ULg)
Full Text
Peer Reviewed
See detailReflexive Introduction to the Categorisation of the European Countryside
Schmitz, Serge ULg

in Siljkovic, Zeljka; Cuka, Anita; Pejdo, Ana (Eds.) Contempory development of European rural areas, Book of Abstracts (2014, September)

At the end of the 20th century, French rural geographers used a simple typology that encapsulates three categories of the countryside: Thirty years later, we should probably add new categories ... [more ▼]

At the end of the 20th century, French rural geographers used a simple typology that encapsulates three categories of the countryside: Thirty years later, we should probably add new categories: “agricultural countryside”, “recreational countryside”, “residential countryside”, “greying countryside”, “countryside supplying energy”, “new peasantry countryside”, “Biosphere reserves” and pay attention to other perspectives such as natural and cultural heritage, water resources protection and ecological transition. The paper discusses these old and new types of countryside and underlines main challenges that countryside faces; it shows how sensitive the categorisation could be according to the level of analysis, the period of observation and the perspectives. [less ▲]

Detailed reference viewed: 11 (2 ULg)
Full Text
Peer Reviewed
See detailImplications of microbial phenotypic heterogeneity in large-scale bioprocessing conditions
Delvigne, Frank ULg; Gorret, Nathalie; Molina-Jouve, Carole et al

Conference (2014, September)

Detailed reference viewed: 8 (1 ULg)
Full Text
See detailAmélioration des moyens d'existence durables. Une voie pour la durabilité des exploitations agricoles familiales de coton au Bénin
Assogba, Claude Gervais; Tossou, C. R.; Lebailly, Philippe ULg et al

Conference (2014, August 30)

Detailed reference viewed: 3 (0 ULg)
Full Text
See detailThe effects of a Global Agricultural Policy on the smallholder farmers in ending hunger
Paveliuc-Olariu, Codrin; Burny, Philippe ULg

Conference (2014, August 30)

Detailed reference viewed: 3 (0 ULg)
Full Text
See detailL'agriculture de subsistance et de semi-subsistance en Roumanie
Dona, Ion; Burny, Philippe ULg

Conference (2014, August 30)

Detailed reference viewed: 5 (1 ULg)
Full Text
See detailAspects économiques de la filière du vermicelle de tolomane au Vietnam
Le Thi Long, Vy; Vu Dinh, Ton; Lebailly, Philippe ULg et al

Conference (2014, August 30)

Detailed reference viewed: 4 (0 ULg)
Full Text
See detailProblématique foncière chez les exploitants agricoles de la Province de Kirundo au nord du Burundi
Minani, Bonaventure; Rurema, Déo-Guide; Burny, Philippe ULg et al

Conference (2014, August 30)

Detailed reference viewed: 7 (3 ULg)
Full Text
Peer Reviewed
See detailAccelerating Random Forests in Scikit-Learn
Louppe, Gilles ULg

Conference (2014, August 29)

Random Forests are without contest one of the most robust, accurate and versatile tools for solving machine learning tasks. Implementing this algorithm properly and efficiently remains however a ... [more ▼]

Random Forests are without contest one of the most robust, accurate and versatile tools for solving machine learning tasks. Implementing this algorithm properly and efficiently remains however a challenging task involving issues that are easily overlooked if not considered with care. In this talk, we present the Random Forests implementation developed within the Scikit-Learn machine learning library. In particular, we describe the iterative team efforts that led us to gradually improve our codebase and eventually make Scikit-Learn's Random Forests one of the most efficient implementations in the scientific ecosystem, across all libraries and programming languages. Algorithmic and technical optimizations that have made this possible include: - An efficient formulation of the decision tree algorithm, tailored for Random Forests; - Cythonization of the tree induction algorithm; - CPU cache optimizations, through low-level organization of data into contiguous memory blocks; - Efficient multi-threading through GIL-free routines; - A dedicated sorting procedure, taking into account the properties of data; - Shared pre-computations whenever critical. Overall, we believe that lessons learned from this case study extend to a broad range of scientific applications and may be of interest to anybody doing data analysis in Python. [less ▲]

Detailed reference viewed: 3 (2 ULg)
Full Text
See detailComputational homogenization of cellular materials with propagation of instabilities through the scales
Nguyen, Van Dung ULg; Noels, Ludovic ULg

Conference (2014, August 29)

The aim of this work is to develop an efficient multi–scale finite element framework to capture the buckling instabilities in cellular materials. As a classical multi–scale computational homogenization ... [more ▼]

The aim of this work is to develop an efficient multi–scale finite element framework to capture the buckling instabilities in cellular materials. As a classical multi–scale computational homogenization scheme looses accuracy with the apparition of the macroscopic localizations resulting from the micro–buckling, the second–order multi–scale computational homogenization scheme1 is considered. This second–order computational framework is herein enhanced with the following novelties so that it can be used for cellular materials. First, at the microscopic scale, the periodic boundary condition is used because of its efficiency. As the meshes generated from cellular materials exhibit a large void part on the boundaries and are not conforming in general, the classical enforcement based on the matching nodes cannot be applied. A new method based on the polynomial interpolation2 without the requirement of the matching mesh condition on opposite boundaries of the representative volume element (RVE) is developed. Next, in order to solve the underlying macroscopic Mindlin strain gradient continuum of this second–order scheme by the displacement–based finite element framework, the treatment of high order terms is based on the discontinuous Galerkin (DG) method to weakly impose the C1-continuity3. Finally, as the instability phenomena are considered at both scales of the cellular materials, the path following technique is adopted to solve both the macroscopic and microscopic problems4. The micro–buckling leading to the macroscopic localization and the size effect phenomena can be captured within the proposed framework. In particular it is shown that results are not dependent on the mesh size at the macroscopic scale during the softening response, and that they agree well with the direct numerical simulations. [less ▲]

Detailed reference viewed: 14 (2 ULg)
Full Text
Peer Reviewed
See detailA post-mortem study of physiopathological characteristics of genital tracts of culled dairy cows in South Vietnam.
Nguyen Kien, Cuong; Okouyi, Marcel; Hanzen, Christian ULg

Poster (2014, August 28)

Detailed reference viewed: 4 (1 ULg)
Full Text
See detailInteractions in massive binaries: spectral modelling – CoMBiSpeC – and observational analyses
Palate, Matthieu ULg

Doctoral thesis (2014)

Massive stars are very important to the life of the galaxiesbut they are rare and many open questions on their formation, evolution and characteristics remain. One of the best ways to improve our ... [more ▼]

Massive stars are very important to the life of the galaxiesbut they are rare and many open questions on their formation, evolution and characteristics remain. One of the best ways to improve our knowledge on massive stars is to study massive binaries (that represent at least 50% of massive stars see Mahy et al. 2009, and Sana & Evans 2011) and their spectra. Spectral and atmosphere modelling of stars are very interesting tools that are now often used in spectral analyses. However, these models are designed for single spherical stars. In this context, we have developed a numerical code of spectral modelling of massive binary systems: CoMBiSpeC (code of massive binary spectral computation) that computes the spectra of massive binary systems and accounts for various effects that affect these systems. Our models, and the observational analyses of the four binary systems presented in the second part of this work, have allowed to explain several effects linked to binarity: luminosity class discrepancy, temperature distribution, Struve-Sahade effect, and some kind of line profile variations. In summary, CoMBiSpeC is a first step in the spectral modelling of massive binary systems and several improvements are still needed to be able to study all massive binaries. Nevertheless, this model can explain and reproduce various observed phenomena which was the main goal of this thesis. [less ▲]

Detailed reference viewed: 20 (8 ULg)
Full Text
See detailDiagnostic de sites et méthode d’implantation de tours pour une insertion urbaine de qualité
Saint-Pierre, Claire ULg

Doctoral thesis (2014)

The matter of towers construction in urban areas has been coming back among topical subjects, taking part in the questioning of sustainable urban development. While the debate still remains as regards ... [more ▼]

The matter of towers construction in urban areas has been coming back among topical subjects, taking part in the questioning of sustainable urban development. While the debate still remains as regards towers legitimacy, location choices are primarily driven by economic considerations (funding, real estate availability) and the issue of urban insertion is not always tackled at the right time. The decision-making process of tower construction is linear and takes into account some criteria relatively late even though if it was done earlier they could anticipate the impact of the tower on its urban environment. Using several comparative analysis (benchmarking), we identified the inherent criteria in this decision-making process. Their analysis and classification allowed us to highlight the preponderance of six criteria and the presence of significant interaction between them: the functionality, the shape, the movement, the public space, the environment and the townscape. The relations which exist between criteria reflect the complexity of the tower location process for which the most appropriate study approach seems to be the systemic. Between the multi-criteria analysis and the systemic approach, our implantation method of towers offers to consider these criteria at the very beginning of the project. Thus, it allows to draw up a list of indicators of urban integration which evaluation will indicate the quality of tower insertion in the urban environment. By considering upstream the identified criteria and also in a regular and diffuse way, the decision-making process of tower construction will be more efficient and effective to help finding the right location for a future tall building project. This implantation method is also designed to give rise discussions and reflections on the topics tackled, so that the dialogue between the actors turns towards a better location of towers in urban areas. [less ▲]

Detailed reference viewed: 14 (6 ULg)
Full Text
See detailMatériaux du futur: ressources naturelles ou secondaires?
Courard, Luc ULg

Scientific conference (2014, August 26)

Detailed reference viewed: 7 (2 ULg)