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See detailFibulin-3 fragments are prognostic biomarkers of osteoarthritis incidence in overweight and obese women
Runhaar, Jos; Sanchez, Christelle ULg; Taralla, Sébastien et al

in Osteoarthritis Cartilage (2016), 24(4), 672-678

OBJECTIVE: To determine the association between three fibulin-3 peptides and the incidence of radiographic and clinical knee osteoarthritis (OA). DESIGN: Women between 50 and 60 years, with a BMI >/=27 kg ... [more ▼]

OBJECTIVE: To determine the association between three fibulin-3 peptides and the incidence of radiographic and clinical knee osteoarthritis (OA). DESIGN: Women between 50 and 60 years, with a BMI >/=27 kg/m2, free of knee OA, were recruited. Using binary logistic regression, the association between baseline concentration of serum fibulin (Fib)3-1, Fib3-2 and Fib3-3 and incidence of clinical and radiographic knee OA after 30 months of follow-up was evaluated. RESULTS: Baseline and follow-up measurements were available for 241 women with a mean age of 55.9 +/- 3.2 years and mean BMI of 31.7 +/- 3.6 kg/m2. None of the concentrations of the three Fib3 epitopes were associated with the incidence of medial or lateral joint space narrowing (JSN) >/=1.0 mm or the incidence of Kellgren & Lawrence (K&L) grade >/=2 after 30 months. All three Fib3 epitopes were associated with the incidence of the clinical and radiographic ACR-criteria and Fib3-1 and Fib3-3 also with chronic pain at follow-up. When adjusted for the other Fib3 peptide concentrations, only Fib3-1 was significantly associated to the incidence of the American College of Rheumatology (ACR)-criteria (OR 3.2 [1.2-8.7]) and chronic pain at follow-up (OR 3.0 [1.2-7.7]). CONCLUSIONS: Baseline fibulin-3 concentrations are associated with the incidence of clinical knee OA among middle-aged overweight and obese women. Therewith, they meet the criteria of a prognostic biomarker according to the BIPED biomarker classification for OA. Further validation of the fibulin-3 epitopes seems warranted in order to better distinguish subgroups of individuals at increased risk for knee OA development. [less ▲]

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See detailReview of soluble biomarkers of osteoarthritis: lessons from animal model
Legrand, Catherine ULg; Lambert, Cécile ULg; Comblain, Fanny ULg et al

in Osteoarthritis and Cartilage (2016, April), 24(suppl 1), 88

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See detailIntensive enteral nutrition is ineffective for individuals with severe alcoholic hepatitis treated with corticosteroids.
Moreno, C; Deltenre, P; Senterre, C et al

in Gastroenterology (2016), 150

BACKGROUND & AIMS: Severe alcoholic hepatitis (AH) is a lifethreatening disease for which adequate oral nutritional support is recommended. We performed a randomized controlled trial to determine whether ... [more ▼]

BACKGROUND & AIMS: Severe alcoholic hepatitis (AH) is a lifethreatening disease for which adequate oral nutritional support is recommended. We performed a randomized controlled trial to determine whether the combination of corticosteroid and intensive enteral nutrition therapy is more effective than corticosteroid therapy alone in patients with severe AH. METHODS: We enrolled 136 heavy consumers of alcohol (age, 18–75 y) with recent onset of jaundice and biopsy-proven severe AH in our study, performed at 18 hospitals in Belgium and 2 in France, from February 2010 through February 2013. Subjects were assigned randomly (1:1) to groups that received either intensive enteral nutrition plus methylprednisolone or conventional nutrition plus methylprednisolone (controls). In the intensive enteral nutrition group, enteral nutrition was given via feeding tube for 14 days. The primary end point was patient survival for 6 months. RESULTS: In an intention-to-treat analysis, we found no significant difference between groups in 6-month cumulative mortality: 44.4% of patients died in the intensive enteral nutrition group (95% confidence interval [CI], 32.2%–55.9%) and 52.1% of controls died (95% CI, 39.4%– 63.4%) (P ¼ .406). The enteral feeding tube was withdrawn prematurely from 48.5% of patients, and serious adverse events considered to be related to enteral nutrition occurred in 5 patients. Regardless of group, a greater proportion of patients with a daily calorie intake less than 21.5 kcal/kg/day died (65.8%; 95% CI, 48.8–78.4) than patients with a higher intake of calories (33.1%; 95% CI, 23.1%–43.4%) (P < .001). CONCLUSIONS: In a randomized trial of patients with severe AH treated with corticosteroids, we found that intensive enteral nutrition was difficult to implement and did not increase survival. However, low daily energy intake was associated with greater mortality, so adequate nutritional intake should be a main goal for treatment. [less ▲]

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See detailOsteoarthritic sclerotic subchondral osteoblasts secreted elevated concentration of fibulin-3 fragments in vitro
Sanchez, Christelle ULg; Lambert, Cécile ULg; Comblain, Fanny ULg et al

in Osteoarthritis and Cartilage (2016, April), 24(suppl 1), 83

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See detailEvidence for the alignment of quasar radio polarizations with large quasar group axes
Pelgrims, Vincent ULg; Hutsemekers, Damien ULg

in Astronomy and Astrophysics (2016)

Recently, evidence has been presented for the polarization vectors from quasars to preferentially align with the axes of the large quasar groups (LQG) to which they belong. This report was based on ... [more ▼]

Recently, evidence has been presented for the polarization vectors from quasars to preferentially align with the axes of the large quasar groups (LQG) to which they belong. This report was based on observations made at optical wavelengths for two large quasar groups at redshift ~1.3. The correlation suggests that the spin axes of quasars preferentially align with their surrounding large-scale structure that is assumed to be traced by the LQGs. Here, we consider a large sample of LQGs built from the Sloan Digital Sky Survey DR7 quasar catalogue in the redshift range 1.0 -􀀀 1.8. For quasars embedded in this sample, we collected radio polarization measurements with the goal to study possible correlations between quasar polarization vectors and the major axis of their host LQGs. Assuming the radio polarization vector is perpendicular to the quasar spin axis, we found that the quasar spin axis is preferentially parallel to the LQG major axis inside LQGs that have at least 20 members. This result independently supports the observations at optical wavelengths. We additionally found that when the richness of an LQG decreases, the quasar spin axis becomes preferentially perpendicular to the LQG major axis and that no correlation is detected for quasar groups with fewer than 10 members. [less ▲]

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See detailMass Surveillance Technology: Trading Trojan Horses
Caponetti, Lia ULg

in Strategic Trade Review (2016), (Spring 2016), 53-71

This paper challenges the effectiveness and necessity of “mass surveillance technology”(MST) on two dimensions: (a) states’ internal use of MST and the subsequent issue of violation of fundamental ... [more ▼]

This paper challenges the effectiveness and necessity of “mass surveillance technology”(MST) on two dimensions: (a) states’ internal use of MST and the subsequent issue of violation of fundamental freedoms, and (b) surveillance technology export control, especially to third countries likely to use such technology to violate human rights. Following the Snowden Datagate scandal, many States undertook inquiries and adopted measures that, in some cases, were meant to regulate the use of mass surveillance technology. The paper will: a) assess and evaluate current regulations on mass surveillance technology and its place in democratic societies, including what is at stake in terms of technology, threats, reactions to threats, and geographic extension, b) the risks linked to the use of MST on the national level by questioning the validity of counter-terrorism measures as a justification for MST use c) analyze international trade control regimes and legislation to highlighting their inadequacy in the face of the threats posed by MST, and d) map the evolution of the EU dual-use trade control system towards a human security approach with regard to human rights protection, in order to assess the capability of the system to avoid the misuse of MST. [less ▲]

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See detailTowards the Minimization of the Levelized Energy Costs of Microgrids using both Long-term and Short-term Storage Devices
François-Lavet, Vincent ULg; Gemine, Quentin ULg; Ernst, Damien ULg et al

in Smart Grid: Networking, Data Management, and Business Models (2016)

This chapter falls within the context of the optimization of the levelized energy cost (LEC) of microgrids featuring photovoltaic panels (PV) associated with both long-term (hydrogen) and short-term ... [more ▼]

This chapter falls within the context of the optimization of the levelized energy cost (LEC) of microgrids featuring photovoltaic panels (PV) associated with both long-term (hydrogen) and short-term (batteries) storage devices. First, we propose a novel formalization of the problem of building and operating microgrids interacting with their surrounding environment. Then we show how to optimally operate a microgrid using linear programming techniques in the context where the consumption and the production are known. It appears that this optimization technique can also be used to address the problem of optimal sizing of the microgrid, for which we propose a robust approach. These contributions are illustrated in two different settings corresponding to Belgian and Spanish data. [less ▲]

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See detailLa multimorbidité : le médecin généraliste et les systèmes de santé mis au défi
Belche, Jean ULg; Crismer, André ULg

in Minerva: Tijdschrift Voor Evidence Based Medicine (2016), 15(3), 55-57

Nous observons une hausse de la prévalence des maladies chroniques et, dans la majorité des situations, la présence concomitante d’au moins deux maladies chroniques, définition minimale de la ... [more ▼]

Nous observons une hausse de la prévalence des maladies chroniques et, dans la majorité des situations, la présence concomitante d’au moins deux maladies chroniques, définition minimale de la multimorbidité, chez un même patient. La manière dont sont structurés la production scientifique et les systèmes de santé, dont le paradigme dominant est la prise en charge de patients avec une seule morbidité, complique la prise en charge adéquate de cette population (1). Søndergaard a dès lors exploré les difficultés que rencontre le médecin généraliste (MG) face aux patients en situation de multimorbidité au travers d’ateliers auxquels ont participé près de 180 MG et chercheurs scandinaves. [less ▲]

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See detailQuelle est l’efficacité de soins collaboratifs et intégrés pour des patients en situation de multimorbidité physique et mentale en ambulatoire ?
Belche, Jean ULg

in Minerva: Tijdschrift Voor Evidence Based Medicine (2016), 15(3), 58-63

Alors que les études cliniques se focalisent principalement sur un problème de santé spécifique avec des patients vierges de comorbidités, il ressort d’une étude épidémiologique publiée en 2012 (1) que la ... [more ▼]

Alors que les études cliniques se focalisent principalement sur un problème de santé spécifique avec des patients vierges de comorbidités, il ressort d’une étude épidémiologique publiée en 2012 (1) que la multimorbidité, définie comme la présence d’au moins 2 maladies chroniques), augmente substantiellement avec l’âge (≥ 65 ans) mais qu’en nombre absolu de patients, elle touche plus de patients plus jeunes (plus de 50% en dessous de 65 ans). Près d’un tiers de ces patients multimorbides souffre de problèmes de santé mentale (dépression, troubles psychotiques, etc.), dont la gravité augmente avec le nombre de comorbidités et le statut socio-économique. L’étude analysée ici fait l’hypothèse d’un bénéfice d’un modèle de soins collaboratif et intégré en première ligne de soins sur la dépression et la gestion de la maladie chronique par le patient, tout en veillant à sélectionner une population représentative du constat démographique actuel de multimorbidité. [less ▲]

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See detailClinically Relevant Optical Properties of Bifocal, Trifocal, and Extended Depth of Focus Intraocular Lenses
Gatinel, Damien; Loicq, Jerôme ULg

in Journal of Refractive Surgery (2016), 32(4), 273-280

PURPOSE: To experimentally compare the optical performance of three types of hydrophobic intraocular lenses (IOLs): extended depth of focus, bifocal, and trifocal. METHODS: The tested IOLs were: TECNIS ... [more ▼]

PURPOSE: To experimentally compare the optical performance of three types of hydrophobic intraocular lenses (IOLs): extended depth of focus, bifocal, and trifocal. METHODS: The tested IOLs were: TECNIS ZMB00 (bifocal; Abbott Medical Optics, Abbott Park, IL), TECNIS Symfony ZXR00 (extended depth of focus; Abbott Medical Optics), and FineVision GFree hydrophobic (trifocal; PhysIOL, Liège, Belgium). Their surface topography was analyzed by optical microscopy. Modulation transfer function (MTF) and spherical aberrations were determined on optical bench for variable pupil apertures and with two cornea models (0 μm and +0.28 μm). United States Air Force target imaging was analyzed for different focal points (near, intermediate, and far). Point spread function (PSF) and halos were quantified and compared. RESULTS: The three lenses presented step-like optic topography. For a pupil size of 3 mm or greater, clearly distinctive MTF peaks were observed for all lenses: two peaks for the extended depth of focus and bifocal lenses with +1.75 and +4.00 diopters (D) addition, respectively, and three peaks for the trifocal lens with +1.75 and +3.50 addition for intermediate and near vision, respectively. The extended depth of focus and bifocal lens had slightly higher MTF at best focus with the +0.28 μm cornea model than with the 0 μm model, whereas the trifocal lens was likely to be more independent of the corneal spherical aberrations.CONCLUSIONS: It appears that the three lenses rely on light diffraction for their optical performance, presenting halos with comparable intensities. For small pupil apertures (< 3 mm), the MTF peaks for the far and intermediate focal distances of the trifocal and extended depth of focus lenses overlap, but the trifocal lens presented an additional MTF peak for the near focal points. [less ▲]

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See detailInfluence of the ionospheric model on DCB computation and added value of LEO satellites
Wautelet, Gilles ULg; Lestarquit, Laurent; Loyer, Sylvain et al

Poster (2016, April)

In order to compute inter-frequency Differential Code Biases (DCBs), the Geometry-Free combination of a GNSS signal pair needs to be corrected from the ionospheric refraction effect. Such information is ... [more ▼]

In order to compute inter-frequency Differential Code Biases (DCBs), the Geometry-Free combination of a GNSS signal pair needs to be corrected from the ionospheric refraction effect. Such information is obtained using either Global Ionospheric Maps (GIMs) or local models. In this work we investigate the influence of GIMs on the final value and precision of DCB solution. The study covers different ionospheric conditions, ranging from very quiet ionospheric background up to a severe ionospheric storm. In a first step, the Slant Total Electron Content (STEC) between GIMs is assessed as a function of receiver latitude, elevation mask and ionospheric conditions. Then, daily DCBs are estimated using these different GIMs, receiver and satellite contributions being separated using a zero-mean constraint. At last, an independent estimation of DCBs is performed using Low Earth Orbit (LEO) observations (such as JASON's GPS data). This solution is compared with our ground network solution and with DCBs coming from Analysis Centers (ACs) of the International GNSS Service providing ionospheric and DCB solutions. [less ▲]

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See detailMAVEN Imaging UV Spectrograph Results on the Mars Atmosphere and Atmospheric Escape
Chaffin; Schneider; McClintock et al

Conference (2016, April)

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See detailGlobal simulation of UV atmospheric emissions on Mars
González-Galindo; López-Valverde; Forget et al

Poster (2016, April)

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See detailThe O2(a1Δ) Venus nightglow intensity: internal versus solar activity control
Soret, Lauriane ULg; Gérard, Jean-Claude ULg

Conference (2016, April)

Introduction: The O2(a1Δg) Venus nightglow emission at 1.27 μm occurs in the atmospheric region governed by the subsolar to antisolar circulation. Several studies showed that the intensity of this ... [more ▼]

Introduction: The O2(a1Δg) Venus nightglow emission at 1.27 μm occurs in the atmospheric region governed by the subsolar to antisolar circulation. Several studies showed that the intensity of this emission is highly variable on a timescale of hours. Here, we study the possible correlation between the solar flux and the O2 infrared emission using VIRTIS-VEx spectral images at 1.27 μm that has been predicted to exist by theVTGCM model calculations by Bougher and Borucki(1994). VIRTIS data: Using the entire VIRTIS-M-IR nadir database, Soret et al. (2014) generated seven statistical maps of the O2(a1Δg) emission, each containing 500 observations. The purpose was to analyze the location of the brightest spot of the emission and its variations over time. Here, we analyze the intensity of the emission over time. Several methods have been used by Soret et al., (2015) to do so (evolution of the emission maximum, evolution of the average intensity, …) Here we present the results of a new analysis using a masking technique to calculate the time evolution of the nightglow brightness. However, none of them follow the same trend over time. Solar flux data: We now focus on solar flux variations in the time of VIRTIS observations (between May 2006 and October 2008), which were collected during a deep solar minimum. We use the SOHO-CELIAS/SEM (Judge et al., 1998) EUV daily average full solar disk fluxes at 1 AU between 0.1 and 50 nm available from the Space Sciences Center of the University of Southern California. EUV0.1–50 daily average fluxes decrease from 2.6 in May 2006 to 1.9 in October 2008 at the Earth. These values have been adapted to Venus by taking into account the distance from the Sun to the planet, but also the shift in date, considering the difference in solar longitude of the two planets. Values at Venus vary from 4.4 to 3.4, which corresponds to a decrease of 10.4% of the solar flux at Venus compared to a complete solar cycle (ranging from 13.5 to 3.9) Comparison of VIRTIS and SEM datasets: The linear correlation coefficient between the solar flux and the intensity peak is found to be 0.62, which expresses the global decreasing trend for both quantities. This coefficient is not higher because internal variations of the two studied variables do not occur simultaneously. More significantly, the correlation coefficient between the solar flux and the averaged intensities is found to be 0.35, meaning that no relation-ship exists between the O2(a1Δg) brightness and the solar activity. Conclusions: Contrary to the VTGCM calculations, we do not observe here a correlation between the O2(a1Δg) brightness and the solar flux. However, VIRTIS data were acquired during a deep solar minimum and, more importantly, during a relatively stable phase of the solar activity. A high level of variability of the O2(a1Δg) emission has been detected in the same dataset from day to day though (Hueso et al., 2008; Soret et al., 2014). It thus appears that the variability is more controlled by internal than external conditions: transport appears to play a major role in the nightglow emissions than the solar activity eventually does. This conclusion is at least valid for solar minimum conditions. A space mission with global imaging capabilities over an entire solar cycle would definitely allow determining the relative role played by solar activity and internal factors. [less ▲]

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See detailInfluence of a liquid nutritional supplement on water intake in experimental Beagle dogs
Rotat, Christelle; Lhoest, Estelle; Rauw, Anaelle ULg et al

in Open Journal of Veterinary Medicine (2016), 6

The objectives were to evaluate the effects of a liquid nutritional supplement formulated for dogs on water intakes and urine output. A liquid nutritional supplement was tested by way of a cross-over ... [more ▼]

The objectives were to evaluate the effects of a liquid nutritional supplement formulated for dogs on water intakes and urine output. A liquid nutritional supplement was tested by way of a cross-over design in 8 experimental healthy Beagle dogs (4 males and 4 females, aged 9.3 years). The supplement (87 percent water, 2.7 percent protein, 2.6 percent fat, 0.4 percent crude fiber) was added to water and tested at 2 incorporation rates (50 or 70 ml/day/dog—D50 or D70) versus the control placebo (CO-water only). The dogs were kept in a controlled environment; water intakes and urine output were measured. Individual water intakes were characterised by large variations. Mean water intake increased significantly by 28 percent in dogs receiving the liquid nutritional supplement, in both genders, irrespectively of the dosage. Urine output was also increased, by 55 percent. Faeces scores remained unchanged. It was concluded that the liquid supplement increased water intake and urine output in a safe way, without increasing dramatically the daily dietary sodium chloride intake. The recommended dosage of the manufacturer—50 ml/day for dogs weighing 10 - 20 kg BW is efficient. Increasing the dosage had no advantage, nor adverse effects. Increased water intake and urine output is of interest for dogs suffering from urolithiasis. [less ▲]

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See detailOpen Access and Discovery Tools: How do Primo Libraries Manage Green Open Access Collections?
Renaville, François ULg

in Varnum, Kenneth J. (Ed.) Exploring Discovery: The Front Door to Your Library's Licensed and Digitized Content (2016)

Scholarly Open Access repositories contain lots of treasures including rare or otherwise unpublished materials and articles that scholars self-archive, often as part of their institution's mandate. But it ... [more ▼]

Scholarly Open Access repositories contain lots of treasures including rare or otherwise unpublished materials and articles that scholars self-archive, often as part of their institution's mandate. But it can be hard to discover this material unless users know exactly where to look. Since the very beginning, libraries have played a major role in supporting the OA movement. Next to all services they can provide to support the deposit of research output in the repositories, they can make Open Access materials widely discoverable by their patrons through general search engines (Google, Bing...), specialized search engines (like Google Scholar) and library discovery tools, thus expanding their collection to include materials that they would not necessarily pay for. In this paper, we intend to focus on two aspects regarding Open Access and Primo discovery tool. In early 2013, Ex Libris Group started to add institutional repositories to Primo Central Index (PCI), their mega-aggregation of hundreds of millions of scholarly e-resources. After 2 years, it may be interesting to take stock of the current situation of PCI regarding Open Access institutional repositories. On basis of a survey to carry out among the Primo community, the paper also shows how libraries using Primo discovery tool integrate Green Open Access contents in their catalog. Two major ways are possible for them: Firstly, they can directly harvest, index and manage any repository in their Primo and display those free contents next to the more traditional library collections; Secondly, if they are PCI subscribers, they can quickly and easily activate any, if not all, of the Open Access repositories contained PCI, making thus the contents of those directly discoverable to their end users. [less ▲]

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See detailUsing a polynomial decoupling algorithm for state-space identification of a Bouc-Wen system
Esfahani, Alireza; Dreesen, Philippe; Tiels, Koen et al

Conference (2016, April)

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See detailA nonlinear state-space solution to a hysteretic benchmark in system identification
Noël, Jean-Philippe ULg; Esfahani, Alireza; Kerschen, Gaëtan ULg et al

Conference (2016, April)

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See detailImpact of tillage on N2O and CO2 efflux in an agricultural crop
Lognoul, Margaux ULg; Theodorakopoulos, Nicolas ULg; Hiel, Marie-Pierre ULg et al

Poster (2016, April)

In an experiment conducted in the Belgian loess belt between June and October 2015, the effect of two tillage treatments (CT - conventional tillage and RT - reduced tillage) on CO2 and N2O fluxes ... [more ▼]

In an experiment conducted in the Belgian loess belt between June and October 2015, the effect of two tillage treatments (CT - conventional tillage and RT - reduced tillage) on CO2 and N2O fluxes exchanged by a maize crop were compared. Fluxes were measured using two fully automated sets of dynamic closed chambers, allowing a 4.5h temporal resolution. Soil water content and temperature were also monitored as well as pH, total N (TN) and total organic C (TOC) content. [less ▲]

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See detailDer Archäotraduktosaurus blickt zurück
Viehöver, Vera ULg

in ReLü: Rezensionszeitschrift zur Literaturübersetzung (2016)

Der Archäotraduktosaurus blickt zurück Vera Viehöver über Sourcier ou cibliste von Jean-René Ladmiral Jean-René Ladmiral, der sich selbst als „letzten Überlebenden eines längst vergangenen, vordigitalen ... [more ▼]

Der Archäotraduktosaurus blickt zurück Vera Viehöver über Sourcier ou cibliste von Jean-René Ladmiral Jean-René Ladmiral, der sich selbst als „letzten Überlebenden eines längst vergangenen, vordigitalen Erdzeitalters der Übersetzung“ sieht, gehört zu den Gründungsvätern der institutionalisierten Übersetzungswissenschaft in Frankreich. Der Band Sourcier ou cibliste (2014) versammelt Beiträge des Autors aus mehr als drei Jahrzehnten, die bislang zum Teil nur schwer auffindbar waren: die Bilanz eines leidenschaftlichen Kämpfers, der ein Übersetzen für die Leser fordert – scharf im Urteil gegen die Sakralisierung und Fetischisierung von literarischen Texten. [less ▲]

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