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See detailStudy of the evolution of the osteoarthritis pathology and the mechanical properties of cartilage in a spontaneous osteoarthritis model in the Dunkin-Hartley guinea pigs.
Legrand, Catherine ULg; Centonze, Prescilia ULg; Comblain, Fanny ULg et al

in Osteoarthritis and Cartilage (2017, April), 25

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan con- tent, the integrity of the tidemark, the cellularity, and osteophytes ... [more ▼]

In animal models, the severity of cartilage damage is assessed by histological scores evaluating the structure, the proteoglycan con- tent, the integrity of the tidemark, the cellularity, and osteophytes. In parallel to these histological analyzes, we studied the mechanical properties of cartilage at different stages of disease progression in the Dunkin-Hartley guinea pigs. We also correlated the severity of histo- logical lesions with the mechanical properties of cartilage. [less ▲]

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See detailLes Q-Codes et la terminologie multilingue de médecine générale et de famille
Jamoulle, Marc ULg; Schuers, Matthieu; Ouvrard, Patrick et al

Conference (2017, March 31)

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See detailClinical sub-categorization of minimally conscious state according to resting functional connectivity
Aubinet, Charlène ULg; Heine, Lizette ULg; Martial, Charlotte ULg et al

Conference (2017, March 31)

Introduction: Patients in a minimally conscious state (MCS) have been subcategorized in MCS plus and MCS minus, respectively with and without command following capacity. Here we aim to characterize ... [more ▼]

Introduction: Patients in a minimally conscious state (MCS) have been subcategorized in MCS plus and MCS minus, respectively with and without command following capacity. Here we aim to characterize differences in MCS plus as compared to MCS minus by means of functional connectivity (FC). Method: Resting state functional magnetic resonance imagery (fMRI) was acquired in 292 MCS patients and a seed-based analysis was conducted on a convenience sample of 19 MCS patients (10 MCS plus and 9 MCS minus) and 35 healthy controls. We investigated the left and right frontoparietal networks (FPN), the auditory network and the default mode network (DMN). We employed a ROI-to-ROI analysis to investigate the inter-hemispheric connectivity and we investigated inter-group differences in grey and white matter volume by means of voxel-based morphometry. Results: We found a higher FC in MCS plus as compared to MCS minus in the left FPN, specifically between the left dorso-lateral prefrontal cortex and the left temporo-occipital fusiform cortex (TOFC). The FC of auditory network, right FPN and DMN, inter-hemispheric connectivity and structure of grey and white matter did not show differences between patients groups. Discussion: Our results suggest that the clinical sub-categorization of MCS is sustained by FC differences in a language-related executive control network. MCS plus and MCS minus patients are not differentiated by networks involved in auditory processing, perception of surroundings and internal thoughts, nor by differences in inter-hemispheric connectivity and in morphology. [less ▲]

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See detailLe fléau des faux médicaments
Marini Djang'Eing'A, Roland ULg; Ziemons, Eric ULg; Sacre, Pierre-Yves ULg et al

Conference given outside the academic context (2017)

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See detailLes mathématiques: une science comme les autres ?
Bair, Jacques ULg

E-print/Working paper (2017)

Les mathématiques sont-elles une science et, dans l'affirmative, sont-elles comparables aux autres disciplines scientifiques comme la physique, la biologie, ... ? Nous apportons des éléments de réponse à ... [more ▼]

Les mathématiques sont-elles une science et, dans l'affirmative, sont-elles comparables aux autres disciplines scientifiques comme la physique, la biologie, ... ? Nous apportons des éléments de réponse à de telles questions en basant principalement nos arguments sur la distinction, due au mathématicien-épistémologue G. Polya, entre les raisonnements plausibles ou démonstratifs. [less ▲]

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See detailThe dual SSTR2/5 specific somatostatin analog, AP102, does not affect glucose metabolism in diabetic ZDF rats: a comparative 14-day infusion study versus pasireotide
Daly, Adrian ULg; Sumeray, Mark

in Abstract Book of the 15th International Pituitary Congress (2017, March 29)

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See detailIntroduction au droit public - Plan général du cours (année 2016-2017)
Behrendt, Christian ULg

Learning material (2017)

Le document constitue le Plan général de l'enseignement d'Introduction au Droit public dispensé à l'Université de Liège en 1ère année de bachelier en droit et en 1ère année de bachelier en science ... [more ▼]

Le document constitue le Plan général de l'enseignement d'Introduction au Droit public dispensé à l'Université de Liège en 1ère année de bachelier en droit et en 1ère année de bachelier en science politique. [less ▲]

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See detailQuelle place pour l'usager dans la stratégie globale de l'entreprise ?
Elsen, Catherine ULg

Conference given outside the academic context (2017)

L'intervention aborde les différentes approches centrées usagers possibles et leur mise en oeuvre en contexte entrepreneurial. La présentation fait particulièrement état de la posture et méthodologie du ... [more ▼]

L'intervention aborde les différentes approches centrées usagers possibles et leur mise en oeuvre en contexte entrepreneurial. La présentation fait particulièrement état de la posture et méthodologie du Design Thinking et en présente les principaux aspects. [less ▲]

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See detailGovernance of plant health and management of crop diversity - the case of common bean health management among members of the association Croqueurs de Carottes
Klaedtke, Stephanie ULg

Doctoral thesis (2017)

All over the globe, networks of seed growers are cultivating crop diversity in fields and gardens. Their contribution to the maintenance of this diversity has been studied, but research has widely left ... [more ▼]

All over the globe, networks of seed growers are cultivating crop diversity in fields and gardens. Their contribution to the maintenance of this diversity has been studied, but research has widely left aside their management of plant health. The governance of bean health practiced by an association of artisanal seed companies, Croqueurs de Carottes, is approached as a case study in the objective of specifying how management of crop diversity and governance of plant health are articulated. Their concern for the governance of bean health is elucidated from an agroecological perspective, taking an interdisciplinary and transformative approach. Actor-network theory constitutes the backbone of the thesis, situated between agronomy and sociology and drawing upon a threefold research device: on-farm experiments, semi-directive interviews and participant observation. The Croqueurs' approach to bean health is described as in situ approach, in which plant populations are considered healthy if they are able to live with potential plant pathogens and adapt to their growing environments. Relying on ecological interactions, competences of plant health management are distributed throughout the production system. Both for plant health and crop diversity management, a seed lot is determined by a complex system of interactions. A clear boundary distinguishing plant populations from their growing environment cannot be drawn. This implies (i) that plant health must be judged upon in situ in the plants' growing environment and (ii) that the governance of plant health must be considered at the collective scale. [less ▲]

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See detailA Markov Chain Monte Carlo Cellular Automata Model to Simulate Urban Growth
El Saeid Mustafa, Ahmed Mohamed ULg; Nishida, Gen; Saadi, Ismaïl ULg et al

in GEOProcessing 2017 proceedings, The Ninth International Conference on Advanced Geographic Information Systems, Applications, and Services (2017, March 25)

This paper investigates the potential of a cellular automata (CA) model based on logistic regression (logit) and Markov Chain Monte Carlo (MCMC) to simulate the dynamics of urban growth. The model ... [more ▼]

This paper investigates the potential of a cellular automata (CA) model based on logistic regression (logit) and Markov Chain Monte Carlo (MCMC) to simulate the dynamics of urban growth. The model assesses urbanization likelihood based on (i) a set of urban development driving forces (calibrated based on logit) and (ii) the land-use of neighboring cells (calibrated based on MCMC). An innovative feature of this CA model is the incorporation of MCMC to automatically calibrate the CA neighborhood transition rules. The MCMC based CA model is applied to Wallonia region (Belgium) to simulate urban growth from 1990 to 2000 using Corine Land Cover data (CLC). The outcome of logit model is evaluated by the relative operating characteristic (ROC). The simulated map of 2000 is then validated against 2000 actual map based on cell-to-cell location agreement. The model outcomes are realistic and relatively accurate confirming the effectiveness of the proposed MCMC-CA approach. [less ▲]

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See detailAnosognosia for behavioral disorder is related to confidence for false self-related memories in Alzheimer’s disease
Mélon, Marlène; Collette, Fabienne ULg; Salmon, Eric ULg et al

Poster (2017, March 24)

Impaired self-awareness (i.e. anosognosia) and altered metacognitive monitoring in memory tasks have both been evidenced in AD. Furthermore, cognitive studies showed disrupted interaction between self and ... [more ▼]

Impaired self-awareness (i.e. anosognosia) and altered metacognitive monitoring in memory tasks have both been evidenced in AD. Furthermore, cognitive studies showed disrupted interaction between self and memory cognitive systems in AD, reducing cognitive advantages of self-related memories (i.e. decreasing self reference effect, SRE) in these patients. However, how anosognosia relates to impaired metacognitive monitoring in AD, particularly for self-related memories, is still an open question. To investigate this question, an ecological memory task based on face-name associations was administrated to 20 healthy older controls (HC) and 20 mild AD patients. The influence of self-reference at encoding was assessed on subsequent name recall and recollective experience, as well as on predictive (feeling-of-knowing, FOK) and postretrieval (judgments-of-confidence, JOC) metacognitive judgments on name recognition in all participants. Furthermore relationships between metacognitive outcomes and awareness of daily cognitive and behavioral impairment was examined in AD. Altered SRE was evidenced in name recall and recollective experience in AD. Patients also showed impaired FOK and JOC, as well as lower awareness of their daily functioning impairment (anosognosia). Nevertheless, differential effect of self on metacognitive judgment in AD and HC was only observed on JOC for false memories. Importantly, anosognosia for behavioral disorders was related to post-retrieval confidence for false recognition of self-related items in AD patients. Thus, anosognosia concerning behavioral disorder and altered post-retrieval monitoring of self-related memories appear to be related in AD. We hypothesized that impaired monitoring of personal false memories may lead AD patients to rely on distorted recent reality when providing judgment about their everyday behavioral functioning. [less ▲]

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See detailDepression is a heterogeneous condition: A cluster-analysis approach
Wagener, Aurélie ULg; Baeyens, Céline; Van der Linden, Martial ULg et al

Poster (2017, March 24)

The heterogeneity of depression (i.e., symptomatology profiles, treatment responsiveness) is more and more evidenced. From a clinical perspective, having a clearer overview of the symptoms’ heterogeneity ... [more ▼]

The heterogeneity of depression (i.e., symptomatology profiles, treatment responsiveness) is more and more evidenced. From a clinical perspective, having a clearer overview of the symptoms’ heterogeneity of depression will help (1) to deeper understand its underlined psychological processes and (2) to tailor clinical treatments (i.e., psychological interventions and/or antidepressant medications). In order to so, an effort to determine subtypes of depression has been developed through a cluster-analysis approach. Andreasen et al. (1980) identified three clusters of depressed patients based on the Schedule for Affective Disorders and Schizophrenia; Schacht et al. (2014) evidenced five clusters based on the Hamilton Depression Rating Scale (i.e., lack of insight, sleep/sexual/somatic, typical MDD, gastrointestinal/weight loss, mild MDD); Hybels et al. (2012) found three clusters of depressive patients based on the Center for Epidemiologic Studies-Depression Scale in community seniors; and Guidi et al. (2011) found two clusters of depressives in medically ill patients based on the Structured Clinical Interview for DSM-IV (i.e., depressed somatizers, irritable/anxious depression). The current study aims at replicating and extending these previous findings in adults presenting depressive symptoms through a cluster-analysis approach. Unlike previous studies, the highlighting of the clusters will be based on the most frequently used assessment of depression, the Beck Depression Inventory-Second Edition (BDI-II). Further, the definition of the clusters will be based on the presence of the depressive symptoms rather than on their severity because symptoms’ severity on the BDI-II can be misrepresentative of the phenomenology of depressive symptoms’ clusters. A sample of 619 adults from community and mental healthcare centers has been recruited. Inclusion criteria were as follows: being a French-speaking adult aged between 18 and 60 years and presenting at least five symptoms on the BDI-II, irrespective of their severity. Data grouping was achieved through a combination of hierarchical (Ward’s method with squared Euclidian distance measurement) and nonhierarchical procedures (K-means cluster analysis), as recommended by recent theoretical trends. A six-cluster solution was evidenced: heavy sleepers (high levels of tiredness, loss of energy and increase of sleep), cognitive depressives (high levels of pessimism, past failures, guilty feelings, self-dislike and worthlessness), affective-somatic depressives (high levels of affective symptoms - loss of interest and pleasure - and somatic symptoms - increase of appetite and sleep, irritability), mild depressives (mild levels of all symptoms), sleepless depressives (high levels of decrease of sleep and tiredness), typical depressives (high levels of all symptoms). Results evidenced the heterogeneity of depressive symptoms, as six different clusters of depressive adults have been found. Two of the clusters identified in the current study are similar to two clusters identified by Schacht et al. (2014) (sleepless depressives are similar to the cluster “sleep/sexual/somatic” because their profile are highly characterized by symptoms related to insomnia and tiredness; mild depressives are similar to the cluster “mild MDD/symptoms” because their profile are characterized by low to average levels on all symptoms). The take-home message of this study is that depression is a heterogeneous condition. Consequently, it is necessary to consider this heterogeneity in order to tailor the psychological intervention. [less ▲]

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See detailIron minerals within specific microfossil morphospecies of the 1.88Ga Gunflint Formation
Lepot, kevin; Addad, Ahmed; Knoll, Andrew H et al

in Nature Communications (2017), DOI: 10.1038/ncomms14890

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See detailInterest of multisite bacterial screening for the diagnosis of congenital listerisosis with negative blood culture: a case report
Snyers, Diane ULg; Thirion, Sophie ULg; Kalenga, Masendu ULg et al

Scientific conference (2017, March 23)

Listeria monocytogenes (LM) is known to cause severe invasive disease in pregnant women and in newborns. Fortunately, despite the wide natural distribution of this pathogen, clinically overt neonatal ... [more ▼]

Listeria monocytogenes (LM) is known to cause severe invasive disease in pregnant women and in newborns. Fortunately, despite the wide natural distribution of this pathogen, clinically overt neonatal infections occurs rarely. As a consequence, listeriosis is not always considered for early onset neonatal infection, especially when blood culture is negative. Indeed, identification of listeria in the blood stream by conventional bacteriological methods remains the reference method for diagnosing listeriosis. We report a case of congenital listeriosis with negative blood culture despite typical chorioamnionitis, where the pathogen was cultured in gastric aspirate.Although the disease is rare, congenital listeriosis still remain a possible challenging condition in neonatal practice as revealed by this case report. This also shows the importance of multisite bacterial culture beside conventional blood and CSF culture, in combination with histological examination of the placenta for the diagnosis of congenital listeriosis. [less ▲]

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