Publications ORBi OA
Bookmark and Share    
Full Text
Peer Reviewed
See detailLipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment
Brohée, Laura ULg; Demine, Stéphane; Willems, Jérôme ULg et al

in Oncotarget (2015), 6(13), 11264-11280

Lipogenesis inhibition was reported to induce apoptosis and repress proliferation of cancer cells while barely affecting normal cells. Lipins exhibit dual function as enzymes catalyzing the ... [more ▼]

Lipogenesis inhibition was reported to induce apoptosis and repress proliferation of cancer cells while barely affecting normal cells. Lipins exhibit dual function as enzymes catalyzing the dephosphorylation of phosphatidic acid to diacylglycerol and as co-transcriptional regulators. Thus, they are able to regulate lipid homeostasis at several nodal points. Here, we show that lipin-1 is up-regulated in several cancer cell lines and overexpressed in 50 % of high grade prostate cancers. The proliferation of prostate and breast cancer cells, but not of non-tumorigenic cells, was repressed upon lipin-1 knock-down. Lipin-1 depletion also decreased cancer cell migration through RhoA activation. Lipin-1 silencing did not significantly affect global lipid synthesis but enhanced the cellular concentration of phosphatidic acid. In parallel, autophagy was induced while AKT and ribosomal protein S6 phosphorylation were repressed. We also observed a compensatory regulation between lipin-1 and lipin-2 and demonstrated that their co-silencing aggravates the phenotype induced by lipin-1 silencing alone. Most interestingly, lipin-1 depletion or lipins inhibition with propranolol sensitized cancer cells to rapamycin. These data indicate that lipin-1 controls main cellular processes involved in cancer progression and that its targeting, alone or in combination with other treatments, could open new avenues in anticancer therapy. [less ▲]

Detailed reference viewed: 11 (3 ULg)
Full Text
See detailMéthodes et innovations pédagogiques en enseignement supérieur
Hanzen, Christian ULg

Learning material (2015)

Cette présentation Power point a été réalisée dans le cadre d'un cycle de conférences données à la faculté de Médecine Vétérinaire de Constantine les 9 et 10 mai 2015. Elle aborde trois aspects ... [more ▼]

Cette présentation Power point a été réalisée dans le cadre d'un cycle de conférences données à la faculté de Médecine Vétérinaire de Constantine les 9 et 10 mai 2015. Elle aborde trois aspects complémentaires à savoir les étudiants, les méthodes et les évaluations. [less ▲]

Detailed reference viewed: 64 (1 ULg)
Full Text
See detail"Drôleries". L'iconographie marginale des portails occidentaux et de la nef de la cathédrale de Strasbourg
Van den Bossche, Benoît ULg

Conference (2015, May 09)

Le vaste ensemble sculpté constitué par les trois portails occidentaux de la cathédrale de Strasbourg a fait l’objet, ces dernières années, de plusieurs études. Une critique d’authenticité a été menée ... [more ▼]

Le vaste ensemble sculpté constitué par les trois portails occidentaux de la cathédrale de Strasbourg a fait l’objet, ces dernières années, de plusieurs études. Une critique d’authenticité a été menée ; les choix iconographiques qui ont présidé à l’élaboration du programme ont été déterminés et justifiés. Toutes ces études ont pourtant laissé de côté une centaine de reliefs finement sculptés qui agrémentent les parties hautes du niveau des portails, à l’extérieur comme à l’intérieur de la façade. Cette iconographie, authentique pour l’essentiel, se distingue par une grande variété de « sujets ». A priori, elle rappelle celle des « drôleries » des manuscrits de la fin du XIIIe siècle et du XIVe. Mais est-ce le cas ? Et si c’est le cas, comment articuler ces sujets qui ont jusqu’à aujourd’hui été considérés comme marginaux, avec l’iconographie des ébrasements, des tympans et des voussures ? Enfin, l’ensemble de « drôleries » de la cathédrale de Strasbourg peut-il, d’un point de vue iconographique, être comparé à d’autres ensembles sculptés français et germaniques de la fin du XIIIe siècle et du XIVe ? [less ▲]

Detailed reference viewed: 10 (1 ULg)
Full Text
See detailRADIOPHARMACY GMP QC HPLC VALIDATION
Aerts, Joël ULg; Giacomelli, Fabrice ULg; Hubert, Philippe ULg et al

Conference (2015, May 09)

Detailed reference viewed: 17 (2 ULg)
Full Text
See detailThe seamod.ro operational stochasting Black Sea forecasting system
Vandenbulcke, Luc ULg; Capet, Arthur; Grégoire, Marilaure ULg et al

Poster (2015, May 08)

Detailed reference viewed: 16 (3 ULg)
Full Text
See detailLa médiation, un lien social à reconstruire.
Bachelet, Jean-François ULg

Conference (2015, May 08)

Detailed reference viewed: 17 (3 ULg)
Full Text
See detailArtificial Intelligence in Video Games: Towards a Unified Framework
Safadi, Firas ULg

Doctoral thesis (2015)

The work presented in this dissertation revolves around the problem of designing artificial intelligence (AI) for video games. This problem becomes increasingly challenging as video games grow in ... [more ▼]

The work presented in this dissertation revolves around the problem of designing artificial intelligence (AI) for video games. This problem becomes increasingly challenging as video games grow in complexity. With modern video games frequently featuring sophisticated and realistic environments, the need for smart and comprehensive agents that understand the various aspects of these environments is pressing. Although machine learning techniques are being successfully applied in a multitude of domains to solve AI problems, they are not yet ready to enable the creation of fully autonomous agent that can reliably learn to understand the environments found in complex video games. Since video game AI is often specifically designed for each game, video game AI tools currently focus on allowing video game developers to quickly and efficiently create specific AI. One issue with this approach is that it does not efficiently exploit the numerous similarities that exist between video games not only of the same genre, but of different genres too, resulting in a difficulty to handle the many aspects of a complex and realistic environment independently for each video game. These similarities, however, exist on a conceptual level. While video games do indeed share a variety of concepts, their interpretations vary from one game to another. Hence, these similarities can only be directly exploited at a conceptual level. Inspired by the human ability to detect analogies between games and apply similar behavior on a conceptual level, this thesis suggests an approach based on the use of a unified conceptual framework to enable the development of conceptual AI which relies on conceptual views and actions to define basic yet reasonable and robust behavior. Because conceptual AI is not tied to any game in particular, it benefits from a continuous development process as opposed to a development that is confined to the scope of a single game project. [less ▲]

Detailed reference viewed: 55 (9 ULg)
Full Text
Peer Reviewed
See detailFuture climate and surface mass balance of Svalbard glaciers in an RCP8.5 climate scenario: a study with the regional climate model MAR forced by MIROC5
Lang, Charlotte ULg; Fettweis, Xavier ULg; Erpicum, Michel ULg

in Cryosphere (The) (2015), 9

We simulated the 21st century Svalbard SMB with the regional model MAR (RCP8.5 scenario). Melt is projected to increase gently up to 2050 and then dramatically increase, with a larger increase in the ... [more ▼]

We simulated the 21st century Svalbard SMB with the regional model MAR (RCP8.5 scenario). Melt is projected to increase gently up to 2050 and then dramatically increase, with a larger increase in the south of the archipelago. This difference is due to larger ice albedo decrease in the south causing larger increase of absorbed solar radiation. The ablation area is projected to disappear over the entire Svalbard by 2085. The SMB decrease compared to present is projected to contribute 7mm to SLR. [less ▲]

Detailed reference viewed: 32 (12 ULg)
Full Text
See detailLatin as literary Language in Constantinople ca. 400-700
Rochette, Bruno ULg

Scientific conference (2015, May 06)

Detailed reference viewed: 20 (3 ULg)
Full Text
Peer Reviewed
See detailSelf-defining memories and self-concept clarity: A comparative study of depressed patients, bipolar patients and healthy subjects
Wagener, Aurélie ULg; Boulanger, Marie ULg; Blairy, Sylvie ULg

Poster (2015, May 06)

Depressed and bipolar patients suffer from autobiographical memory (AM) deficits. For instance, depressed patients present an overgeneralisation and a mood congruence biases. Indeed, these patients seem ... [more ▼]

Depressed and bipolar patients suffer from autobiographical memory (AM) deficits. For instance, depressed patients present an overgeneralisation and a mood congruence biases. Indeed, these patients seem to have difficulties to recall specific and positive memories. The present study focusses on a particular kind of memories: the self-defining memories (SDMs). SDMs are highly pertinent for self-building: they help to define in the most clearly way our perception of ourselves. Because SDMs have not been studied a lot since yet in these two disorders, our goal is to assess the impact of general AM biases on SDMs. Then, the present study pursues two main aims: 1) To assess SDM’s characteristics, 2) To assess the relationship between SDM and self-concept clarity. To reach our objective, depressed and bipolar patients are compared to healthy subjects. Participants are asked to complete SDMs exercises that are recalling six important events which happened in their life. These SDMs are assessed on four variables: specificity, impact, meaning making, contain. Self-concept clarity and mood are also assessed. Until now, 17 depressed patients, 16 bipolar patients and 18 healthy controls participate in this study. Preliminary results do not highlight difference between our groups on specificity. Marginal effects appear for meaning making with healthy subjects recalling more meaning making events. Results show that depressed patients present a mood congruence. The final results will be presented during the convention, as data-collection is on-going and will end in April. Experimental and clinical implications of our results will be discussed. [less ▲]

Detailed reference viewed: 33 (0 ULg)
Full Text
Peer Reviewed
See detailA fungal biofilm reactor based on metal structured packing improves the quality of a Gla::GFP fusion protein produced by Aspergillus oryzae
Zune, Quentin ULg; Delepierre, Anissa ULg; Gofflot, Sebastien et al

in Applied Microbiology and Biotechnology (2015)

Fungal biofilm is known to promote the excretion of secondary metabolites in accordance with solid-state related physiological mechanisms. This work is based on the comparative analysis of classical ... [more ▼]

Fungal biofilm is known to promote the excretion of secondary metabolites in accordance with solid-state related physiological mechanisms. This work is based on the comparative analysis of classical submerged fermentation with a fungal biofilm reactor for the production of a Gla::GFP fusion protein by Aspergillus oryzae. The biofilm reactor comprises a metal structured packing allowing the attachment of the fungal biomass. Since the production of the target protein is under the control of the promoter glaB, specifically induced in solid-state fermentation, the biofilm mode of culture is expected to enhance the global productivity. Although production of the target protein was enhanced by using the biofilm mode of culture, we also found that fusion protein production is also significant when the submerged mode of culture is used. This result is related to high shear stress leading to biomass autolysis and leakage of intracellular fusion protein into the extracellular medium. Moreover, 2D-gel electrophoresis highlights the preservation of fusion protein integrity produced in biofilm conditions. Two fungal biofilm reactor designs were then investigated further, i.e. with full immersion of the packing or with medium recirculation on the packing, and the scale-up potentialities were evaluated. In this context, it has been shown that full immersion of the metal packing in the liquid medium during cultivation allows for a uniform colonization of the packing by the fungal biomass and leads to a better quality of the fusion protein. [less ▲]

Detailed reference viewed: 17 (2 ULg)
Full Text
See detailTowards a typology of hieroglyphic sign functions. Categorization and fluidity in the description of semiotic systems
Polis, Stéphane ULg

Scientific conference (2015, May 06)

The understanding of the functions of the signs in the hieroglyphic writing system has been an issue ever since knowledge of this script was lost during Late Antiquity. If ancient authors like Horapollo ... [more ▼]

The understanding of the functions of the signs in the hieroglyphic writing system has been an issue ever since knowledge of this script was lost during Late Antiquity. If ancient authors like Horapollo were still aware of the meaning of some hieroglyphs, they were often unable to correctly explain why these signs had such meanings. Jean-François Champollion’s famous Lettre à M. Dacier relative à l’alphabet des hiéroglyphes phonétiques (1822) was to change this state of affair, when the French scholar identified signs “doués de la faculté d’exprimer des sons”. In my lecture, I will review the insights of Egyptologists regarding the functions of hieroglyphs (from Champollion to contemporary scholars, like Kammerzell, Morenz, Schenkel, Vernus and Winand) and argue that the combination of three key-features — namely, semography, phonemography and autonomy — is necessary and sufficient in order to provide a description of the so-called ‘glottic’ functions of the ancient Egyptian graphemes. In a second part of the talk, I provide prototypical examples for each category and discuss interesting cases, which are somehow at the borders between categories, so as to illustrate the diachronic and synchronic gradience of the system. [less ▲]

Detailed reference viewed: 36 (3 ULg)
Full Text
See detailConsultation citoyenne européenne sur la consommation durable du 25 octobre 2014. Rapport sur la consultation citoyenne organisée le 25 octobre 2014 à l'échelle de la Wallonie
Delvenne, Pierre ULg; Macq, Hadrien; Parotte, Céline ULg et al

Report (2015)

Le 25 octobre 2014, une vaste consultation citoyenne s’est déroulée simultanément dans 11 pays européens sur le thème de la consommation durable. Au total, ce sont un peu plus d’un millier de participants ... [more ▼]

Le 25 octobre 2014, une vaste consultation citoyenne s’est déroulée simultanément dans 11 pays européens sur le thème de la consommation durable. Au total, ce sont un peu plus d’un millier de participants qui ont pris part à la discussion à travers l’Europe. En Belgique, l’évènement se déroulait à l’échelle de la Wallonie et le panel citoyen a réuni 105 participants, sélectionnés selon des critères liés au genre, à l’âge, à la répartition géographique, au niveau d’études et à la catégorie socio-professionnelle. Les résultats de cette enquête participative montrent que tous, aussi bien citoyens-consommateurs, producteurs que décideurs politiques ont un rôle à jouer dans la consommation durable. Plus précisément, les participants ont exprimé la volonté que les élus encouragent la consommation durable et rendent son accès plus aisé aux citoyens. En conclusion, les 105 citoyens participant à cette journée se sont largement exprimés concernant leurs habitudes mais aussi leurs demandes vis-à-vis des pouvoirs publics concernant la consommation durable, un sujet auquel une écrasante majorité s’est déclarée très sensible. Outre les demandes citoyennes mises en exergue ci-dessus (éduquer et inciter à l’action quotidienne en faveur de la consommation durable, la rendre moins coûteuse, améliorer et renforcer l’offre de transports en commun), les participants ont également émis le souhait d’être davantage consultés dans la prise des décisions politiques, par le biais de mécanismes participatifs élargis au sein desquels ils peuvent jouer un rôle actif en soutien aux processus politiques. [less ▲]

Detailed reference viewed: 34 (8 ULg)
Full Text
See detailLes tabous à l’école : quelle place pour le juge en classe ?
Grandjean, Geoffrey ULg

Conference (2015, May 05)

L’objectif de la conférence est de revenir sur le concept de tabou en le liant à différents cas concrets rencontrés en milieu scolaire. L’exposé montre la place croissante accordée aux juges face à des ... [more ▼]

L’objectif de la conférence est de revenir sur le concept de tabou en le liant à différents cas concrets rencontrés en milieu scolaire. L’exposé montre la place croissante accordée aux juges face à des tabous qui suscitent des conflits. Une réflexion politologique est proposée par rapport au phénomène de judiciarisation. [less ▲]

Detailed reference viewed: 14 (1 ULg)
Full Text
See detailTowards an extension of the catalogue of particle-accelerating colliding-wind binaries
De Becker, Michaël ULg

Conference (2015, May 05)

Particle-accelerating colliding-wind binaries (PACWBs) constitute a class of massive stars known to be able to accelerate charged particles up to relativistic velocities. The latter property is identified ... [more ▼]

Particle-accelerating colliding-wind binaries (PACWBs) constitute a class of massive stars known to be able to accelerate charged particles up to relativistic velocities. The latter property is identified mainly through the detection of synchrotron radiation in the radio domain, and in a few cases thanks to the detection of non-thermal radiation in the high energy domain. The catalogue of PACWBs contains about 40 objects, covering a wide parameter space in terms of stellar wind and orbital parameters. So far, there is no evidence for a strict criterion to justify the occurrence of a particle acceleration process only in a small fraction of the colliding-wind binaries population, admitting the possibility that it might be a frequent property among massive stars. In this contribution, I address the issue of the frequency of particle accelerators among massive binaries, and I discuss observation strategies aiming at identifying new members of the catalogue. [less ▲]

Detailed reference viewed: 15 (1 ULg)
Full Text
Peer Reviewed
See detailPsychological processes leading to activation or avoidance: Protective and vulnerability factors to depression
Wagener, Aurélie ULg

Conference (2015, May 05)

Kinderman (2005, 2013) elaborated a psychological model of mental ill-health according to which biological, social and circumstantial factors lead to mental disorders through their conjoint effects on ... [more ▼]

Kinderman (2005, 2013) elaborated a psychological model of mental ill-health according to which biological, social and circumstantial factors lead to mental disorders through their conjoint effects on psychological processes (PP). Our research adopted the same framework. It focused on PP which characterize depression. More precisely, since inactivity (also conceptualized as behavioural avoidance) is one of the main feature of depression, the present research focused on PP which influence the behavioural avoidance (vulnerability factor to depression) and the behavioural activation (protective factor for depression). Three main aims were pursued: To investigate the influence of the biased PP on the behavioural avoidance. To find the PP which have a positive influence on the behavioural activation. To present an integration of our results with Kinderman’s model. Four hundred seventy-seven community adults (358 women, 119 men; x ̅ age = 34.25, SD = 11.85) completed an online survey assessing PP (negative repetitive thoughts, emotion regulation strategies, environmental rewards, self-image, inhibition/approach), avoidance, activation and depression. Since several questionnaires were used to assess each PP, factorial scores were computed for each one. Overall, confirmatory factor analyses highlighted that avoidance is positively linked to ruminations, negative emotion regulation strategies and poor environmental rewards and that activation is positively linked to positive self-image and high environmental satisfaction. Results will also be discussed according to the sex. According to their influence on both avoidance and activation, the environmental reward and the emotion regulation strategies appear to be important variables to work on during the treatment of depression. [less ▲]

Detailed reference viewed: 24 (1 ULg)
Full Text
See detailUse of GEOS-Chem for the interpretation of long-term FTIR measurements at the Jungfraujoch and other NDACC sites
Mahieu, Emmanuel ULg; Bovy, Benoît ULg; Bader, Whitney ULg et al

Poster (2015, May 04)

We present recent and ongoing investigations using 3D CTM GEOS-Chem model simulations for the interpretation of long-term FTIR measurements performed at selected NDACC sites.

Detailed reference viewed: 15 (8 ULg)