Publications ORBi OA
Bookmark and Share    
Full Text
Peer Reviewed
See detailBiolaw and dual use dilemma: the freedom of scientific research in relationship with traditional and emerging sciences and technologies
Colussi, Ilaria Anna ULg

in International Journal of Biolaw (in press)

Science and technology require an intervention by the law, and law is called upon to intervene in front of their evolution, and to look for proper solutions of governance and rational responses to their ... [more ▼]

Science and technology require an intervention by the law, and law is called upon to intervene in front of their evolution, and to look for proper solutions of governance and rational responses to their risks. One of the main issues to be investigated from the legal viewpoint is represented by the ‘dual-use dilemma’ that arises both in ‘traditional’ and new areas of techno-sciences. Indeed, any kind of research has the potential to be used both for bad as well as for good purposes. Therefore, it is important to reflect upon the ways to control possibly dangerous research without preventing the progress from going further. Such ‘dual-use dilemma’, then, entails the study of one of the fundamental freedoms in the biolaw area: the freedom of scientific research, its limits, and relationship with other rights/needs/freedoms (such the need of security). This work focuses on two areas of the techno-scientific world. One is more ‘traditional’, i.e. nuclear science, in whose context the reflections on ‘dual-use’ were born and developed, and the other one is a new emerging technology, which is synthetic biology. The aim is to understand how the freedom of scientific research could be shaped in relationship with other rights/needs/interests for dealing with ‘dual-use’ issues in the aforementioned areas of science and technology. [less ▲]

Detailed reference viewed: 64 (2 ULg)
Full Text
Peer Reviewed
See detailA Quantitative Doignon-Bell-Scarf theorem
Aliev, Iskander; Bassett, Robert; De Loera, Jesus et al

in Combinatorica (in press)

The famous Doignon-Bell-Scarf theorem is a Helly-type result about the existence of integer solutions to systems of linear inequalities. The purpose of this paper is to present the following quantitative ... [more ▼]

The famous Doignon-Bell-Scarf theorem is a Helly-type result about the existence of integer solutions to systems of linear inequalities. The purpose of this paper is to present the following quantitative generalization: Given an integer k, we prove that there exists a constant c(n,k), depending only on the dimension n and on the number k, such that if a bounded polyhedron {x in R^n : Ax <= b} contains exactly k integer points, then there exists a subset of the rows, of cardinality no more than c(n,k), defining a polyhedron that contains exactly the same k integer points. In this case c(n,0)=2^n as in the original case of Doignon-Bell-Scarf for infeasible systems of inequalities. We work on both upper and lower bounds for the constant c(n,k) and discuss some consequences, including a Clarkson-style algorithm to find the l-th best solution of an integer program with respect to the ordering induced by the objective function. [less ▲]

Detailed reference viewed: 68 (11 ULg)
Full Text
Peer Reviewed
See detailOpen Implementation of DICOM for Whole-Slide Microscopic Imaging
JODOGNE, Sébastien ULg; LENAERTS, Eric ULg; MARQUET, Lara ULg et al

in Proceedings, 12th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications (VISAPP 2017) (in press)

This paper introduces an open implementation of DICOM for whole-slide microscopic imaging, following Supplement 145 of the DICOM standard. The software is divided into two parts: (a) a command-line tool ... [more ▼]

This paper introduces an open implementation of DICOM for whole-slide microscopic imaging, following Supplement 145 of the DICOM standard. The software is divided into two parts: (a) a command-line tool to convert an whole-slide image to the DICOM format, and (b) a zero-footprint Web interface to display such DICOM images. The software architecture leverages the DICOM server Orthanc. The entire framework is available as free and open-source software. The existence of this software supports the development of digital pathology and telepathology in clinical environments, featuring a smooth integration with existing EHR and PACS solutions. [less ▲]

Detailed reference viewed: 96 (13 ULg)
Full Text
Peer Reviewed
See detailOn the Zero Defect Conjecture
Labbé, Sébastien ULg; Starosta, Stepan; Pelantova, Edita

in European Journal of Combinatorics (in press)

Detailed reference viewed: 31 (8 ULg)
Full Text
Peer Reviewed
See detailDer individuelle Rechtsschutz gegen Verwaltungshandlungen - Landesbericht Belgien
Behrendt, Christian ULg; Miny, Xavier ULg

in Huber, Peter M.; von Bogdandy, Armin (Eds.) Ius Publicum Europaeum, vol. VIII (in press)

Detailed reference viewed: 33 (3 ULg)
Full Text
See detailCarte géologique de Wallonie (Belgique) 1/10.000, 48/8 Clavier
Barchy, Laurent; Marion, Jean-Marc ULg

Cartographic material (in press)

New geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced since the previous edition in 1902 (at 1/40.000, by Lohest, Forir ... [more ▼]

New geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced since the previous edition in 1902 (at 1/40.000, by Lohest, Forir and Mourlon). [less ▲]

Detailed reference viewed: 81 (11 ULg)
Full Text
See detailCarte géologique de Wallonie (Belgique) 1/10.000, 48/7 Modave
Barchy, Laurent; Marion, Jean-Marc ULg

Cartographic material (in press)

New geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced since the previous edition in 1902 (at 1/40.000, by Lohest, Forir ... [more ▼]

New geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced since the previous edition in 1902 (at 1/40.000, by Lohest, Forir and Mourlon). [less ▲]

Detailed reference viewed: 206 (16 ULg)
Full Text
See detailCarte géologique de Wallonie. Huy-Nandrin n°48/3-4
Mottequin, Bernard; Marion, Jean-Marc ULg

Cartographic material (in press)

New geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced since the first edition by Gustave Dewalque & colleagues (1898 ... [more ▼]

New geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced since the first edition by Gustave Dewalque & colleagues (1898) published at the scale of 1/40.000 [less ▲]

Detailed reference viewed: 62 (7 ULg)
Full Text
Peer Reviewed
See detailPsychological interventions influence patients' attitudes and beliefs about their chronic pain.
VANHAUDENHUYSE, Audrey ULg; Gillet, Aline; MALAISE, Nicole ULg et al

in Journal of Traditional and Complementary Medicine (in press)

Detailed reference viewed: 65 (13 ULg)
Full Text
Peer Reviewed
See detailCytotoxic T-lymphocyte-associated protein 4-Ig effectively controls immune activation and inflammatory disease in a novel murine model of leaky severe combined immunodeficiency
Humblet-Baron, Stephanie; Schönefeldt, Susan; Garcia-Perez, Josselyn E et al

in Journal of Allergy and Clinical Immunology (The) (in press)

Background: Severe combined immunodeficiency (SCID) can be caused by loss-of-function mutations in genes involved in the DNA recombination machinery, such as RAG1, RAG2 or DCLRE1C. Defective DNA ... [more ▼]

Background: Severe combined immunodeficiency (SCID) can be caused by loss-of-function mutations in genes involved in the DNA recombination machinery, such as RAG1, RAG2 or DCLRE1C. Defective DNA recombination causes a developmental block in T cells and B cells, resulting in high susceptibility to infections. Hypomorphic mutations in the same genes can also give a partial loss of T cells, in a spectrum including leaky SCID (LS) and Omenn syndrome (OS). These patients not only develop life-threatening infections due to immunodeficiency, but also develop inflammatory/autoimmune conditions due to the presence of autoreactive T cells. Objective: We sought to develop a preclinical model that fully recapitulates the symptoms of LS/OS patients including a model for testing therapeutic intervention. Methods: We generated a novel mutant mouse (Dclre1c leaky) that develops a LS phenotype. Mice were monitored for diseases and immune phenotype and immune function were evaluated using flow cytometry, ELISA and histology. Results: Dclre1c leaky mice present with a complete blockade of B cell differentiation, with a leaky block in T cell differentiation resulting in an oligoclonal TCR repertoire and enhanced cytokine secretion. Dclre1c leaky mice also developed inflammatory symptoms including wasting, dermatitis, colitis, hypereosinophilia and high IgE levels. Development of a preclinical murine model for LS allowed the testing of potential treatment, with administration of CTLA4-Ig reducing disease symptoms and immunological disturbance, resulting in increased survival. Conclusion: These data suggest that CTLA4-Ig should be evaluated as a potential treatment of inflammatory symptoms in LS and OS patients. [less ▲]

Detailed reference viewed: 29 (4 ULg)
Full Text
Peer Reviewed
See detailDe l'état littéraire à une théorie de l'Etat. Une lecture cursive de La Musique et les Lettres
Durand, Pascal ULg

in Millan, Gordon (Ed.) Mallarmé à Tournon et au-delà (in press)

Detailed reference viewed: 95 (26 ULg)
Full Text
Peer Reviewed
See detailThe unexpected discovery of Brucella abortus Buck 19 vaccine in goats from Ecuador underlines the importance of biosecurity measures
Ron-Roman, J; Berkvens, D; Barzallo-Rivadeneira, D et al

in Tropical Animal Health and Production (in press)

Detailed reference viewed: 5 (1 ULg)
Full Text
Peer Reviewed
See detailMulti-temporal monitoring of a regional riparian buffer network (>12,000 km) with LiDAR and photogrammetric point clouds
Michez, Adrien ULg; Piégay, Hervé; Lejeune, Philippe ULg et al

in Journal of Environmental Management (in press)

Riparian buffers are of major concern for land and water resource managers despite their relatively low spatial coverage. In Europe, this concern has been acknowledged by different environmental ... [more ▼]

Riparian buffers are of major concern for land and water resource managers despite their relatively low spatial coverage. In Europe, this concern has been acknowledged by different environmental directives which recommend multi-scale monitoring (from local to regional scales). Remote sensing methods could be a cost-effective alternative to field-based monitoring, to build replicable “wall-to-wall” monitoring strategies of large river networks and associated riparian buffers. The main goal of our study is to extract and analyze various parameters of the riparian buffers of up to 12,000 km of river in southern Belgium (Wallonia) from three-dimensional (3D) point clouds based on LiDAR and photogrammetric surveys to i) map riparian buffers parameters on different scales, ii) interpret the regional patterns of the riparian buffers and iii) propose new riparian buffer management indicators. We propose different strategies to synthesize and visualize relevant information at different spatial scales ranging from local (<10 km) to regional scale (>12,000 km). Our results showed that the selected parameters had a clear regional pattern. The reaches of Ardenne ecoregion have channels with the highest flow widths and shallowest depths. In contrast, the reaches of the Loam ecoregion have the narrowest and deepest flow channels. Regional variability in channel width and depth is used to locate management units potentially affected by human impact. Riparian forest of the Loam ecoregion is characterized by the lowest longitudinal continuity and mean tree height, underlining significant human disturbance. As the availability of 3D point clouds at the regional scale is constantly growing, our study proposes reproducible methods which can be integrated into regional monitoring by land managers. With LiDAR still being relatively expensive to acquire, the use of photogrammetric point clouds combined with LiDAR data is a cost-effective means to update the characterization of the riparian forest conditions. [less ▲]

Detailed reference viewed: 39 (8 ULg)
Full Text
Peer Reviewed
See detailOutbreak investigations and molecular characterization of foot-and-mouth disease viruses circulating in southwest Niger
Kouato; Fana, EM; King, DP et al

in Transboundary and Emerging Diseases (in press)

Detailed reference viewed: 8 (4 ULg)
Full Text
Peer Reviewed
See detailThe Antitrust and Intellectual Property Intersection in European Union Law
Petit, Nicolas ULg

in Blair, Roger; Sokol, Danie (Eds.) Roger D. Blair & D. Daniel Sokol (in press)

In European legal scholarship, many articles discuss the equilibrium reached in the case-law of the Court of Justice of the European Union (“CJEU”) when the EU antitrust prohibitions apply to, and ... [more ▼]

In European legal scholarship, many articles discuss the equilibrium reached in the case-law of the Court of Justice of the European Union (“CJEU”) when the EU antitrust prohibitions apply to, and restrain, the free and ordinary use of intellectual property rights (“IPRs”). We call this the antitrust-IP intersection. The most interesting feature of this literature is perhaps the common assumption that a unifying substantive perspective, vision or theory on IPR underpins the intersection point reached by the antitrust case-law. Whilst the theory of “absolutism” can be quickly disposed of, several other theories like inherency, exceptionalism or complementarity have been described as the lynchpin of the antitrust-IP intersection. Our paper offers a different reading of the case-law. It submits that the antitrust-IP intersection does not rest on any unitary theory which, in turn, bespeaks the Court’s vision of the social function of IPRs. Instead, the main feature of the CJEU case-law is that a specific methodology is applied to antitrust cases with IPR ramifications. The CJEU deals with most of such cases under a rule-based approach, instead of a standard-based approach. By rule-based approach, we refer to the ex ante setting of structured tests of liability, by opposition to ex post case-by-case resolution on grounds of a pre-determined, general standard (e.g., reasonableness, competition on the merits, efficiency, fairness, equity, etc.). As will be seen below, this approach has many virtues, not least in terms of legal certainty. But it also has a major qualification. Whilst the Court has consistently formulated rules of liability and justifiability at the antitrust and IP intersection, it has at the same time often embedded abstract standards within those rules. The implications of this mixed approach are unclear. [less ▲]

Detailed reference viewed: 99 (5 ULg)
Full Text
Peer Reviewed
See detailInclusion of Down Syndrome in Architectural Design: Towards a Methodology
Schelings, Clémentine ULg; Elsen, Catherine ULg

in Proceedings of the second international conference on Universal Accessibility in the Internet of Things and Smart Environments (in press)

This paper develops an in-situ methodology to help architects insure better inclusion of people with Down syndrome all along preliminary phases of the architectural design process, and eventually to the ... [more ▼]

This paper develops an in-situ methodology to help architects insure better inclusion of people with Down syndrome all along preliminary phases of the architectural design process, and eventually to the designed space. This methodology first offers architects some design keys in regard of how people with Down syndrome interact with two types of spaces: their personal dwellings and some completely unknown spaces. The methodology then unfolds towards more pro-active inclusion of the participants thanks to playful expression of their feelings and perceptions. This paper discusses how this methodology relates to inclusive and universal design principles as well as prevalent models of disability in architecture. [less ▲]

Detailed reference viewed: 63 (14 ULg)
Full Text
Peer Reviewed
See detailGuided Dive for the Spatial Branch-and-Bound
Gerard, Damien ULg; Koeppe, Matthias; Louveaux, Quentin ULg

in Journal of Global Optimization (in press)

We study the spatial Brand-and-Bound algorithm for the global opti- mization of nonlinear problems. In particular we are interested in a method to find quickly good feasible solutions. Most spatial Branch ... [more ▼]

We study the spatial Brand-and-Bound algorithm for the global opti- mization of nonlinear problems. In particular we are interested in a method to find quickly good feasible solutions. Most spatial Branch-and-Bound-based solvers use a non-global solver at a few nodes to try to find better incumbents. We show that it is possible to improve the branching rules and the node priority by exploiting the solutions from the non-global solver. We also propose several smart adaptive strategies to choose when to run the non-global solver. We show that despite the time spent in solving more NLP problems in the nodes, the new strategies enable the algorithm to find the first good incumbents faster and to prove the global opti- mality faster. Numerous easy, medium size as well as hard NLP instances from the Coconut library are benchmarked. All experiments are run using the open source solver Couenne. [less ▲]

Detailed reference viewed: 19 (2 ULg)
Full Text
See detailFrom seascape level to functional ecology: A case study over P. oceanica seagrass meadows in Calvi, Corsica
Lapeyra Martin, Jon ULg; Abadie, Arnaud; Richir, Jonathan ULg et al

in Actes du colloque Carhamb'ar 2017 (in press)

see long abstract

Detailed reference viewed: 44 (11 ULg)
Full Text
See detailHarzé - La Gleize. Carte géologique de la Wallonie. Notice explicative
Lamberty, Pauline ULg; Marion, Jean-Marc ULg; Mottequin, Bernard et al

Book published by SPW/Editions (in press)

New geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced, since the first edition published in 1899 (Gustave Dewalque) at ... [more ▼]

New geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced, since the first edition published in 1899 (Gustave Dewalque) at the scale of 1/40.000 by the "Commission Géologique de Belgique" and the second one, published in 1959 (Asselberghs & Geukens) at the scale of 1/40.000 by the Geological Survey of Belgium. [less ▲]

Detailed reference viewed: 57 (38 ULg)
Full Text
See detailCarte géologique de la Wallonie à l'échelle 1:25.000. Stavelot - Malmedy n°50/5-6
Lamberty, Pauline ULg; Geukens, Fernand; Marion, Jean-Marc ULg

Cartographic material (in press)

New geological map of Wallonia that will be published at the scale of 1/25.000, based on a new field work and using previous scientific data produced, since the first edition published in 1899 (Gustave ... [more ▼]

New geological map of Wallonia that will be published at the scale of 1/25.000, based on a new field work and using previous scientific data produced, since the first edition published in 1899 (Gustave Dewalque) at the scale of 1/40,000 by the "Commission Géologique de Belgique" and the second one, published in 1963 (Fernand Geukens) at the scale of 1/25,000 by the Geological Survey of Belgium. [less ▲]

Detailed reference viewed: 53 (13 ULg)