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See detailLe fléau des faux médicaments
Marini Djang'Eing'A, Roland ULg; Ziemons, Eric ULg; Sacre, Pierre-Yves ULg et al

Conference given outside the academic context (2017)

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See detailLes mathématiques: une science comme les autres ?
Bair, Jacques ULg

E-print/Working paper (2017)

Les mathématiques sont-elles une science et, dans l'affirmative, sont-elles comparables aux autres disciplines scientifiques comme la physique, la biologie, ... ? Nous apportons des éléments de réponse à ... [more ▼]

Les mathématiques sont-elles une science et, dans l'affirmative, sont-elles comparables aux autres disciplines scientifiques comme la physique, la biologie, ... ? Nous apportons des éléments de réponse à de telles questions en basant principalement nos arguments sur la distinction, due au mathématicien-épistémologue G. Polya, entre les raisonnements plausibles ou démonstratifs. [less ▲]

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See detailThe dual SSTR2/5 specific somatostatin analog, AP102, does not affect glucose metabolism in diabetic ZDF rats: a comparative 14-day infusion study versus pasireotide
Daly, Adrian ULg; Sumeray, Mark

in Abstract Book of the 15th International Pituitary Congress (2017, March 29)

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See detailIntroduction au droit public - Plan général du cours (année 2016-2017)
Behrendt, Christian ULg

Learning material (2017)

Le document constitue le Plan général de l'enseignement d'Introduction au Droit public dispensé à l'Université de Liège en 1ère année de bachelier en droit et en 1ère année de bachelier en science ... [more ▼]

Le document constitue le Plan général de l'enseignement d'Introduction au Droit public dispensé à l'Université de Liège en 1ère année de bachelier en droit et en 1ère année de bachelier en science politique. [less ▲]

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See detailA Markov Chain Monte Carlo Cellular Automata Model to Simulate Urban Growth
El Saeid Mustafa, Ahmed Mohamed ULg; Nishida, Gen; Saadi, Ismaïl ULg et al

in GEOProcessing 2017 proceedings, The Ninth International Conference on Advanced Geographic Information Systems, Applications, and Services (2017, March 25)

This paper investigates the potential of a cellular automata (CA) model based on logistic regression (logit) and Markov Chain Monte Carlo (MCMC) to simulate the dynamics of urban growth. The model ... [more ▼]

This paper investigates the potential of a cellular automata (CA) model based on logistic regression (logit) and Markov Chain Monte Carlo (MCMC) to simulate the dynamics of urban growth. The model assesses urbanization likelihood based on (i) a set of urban development driving forces (calibrated based on logit) and (ii) the land-use of neighboring cells (calibrated based on MCMC). An innovative feature of this CA model is the incorporation of MCMC to automatically calibrate the CA neighborhood transition rules. The MCMC based CA model is applied to Wallonia region (Belgium) to simulate urban growth from 1990 to 2000 using Corine Land Cover data (CLC). The outcome of logit model is evaluated by the relative operating characteristic (ROC). The simulated map of 2000 is then validated against 2000 actual map based on cell-to-cell location agreement. The model outcomes are realistic and relatively accurate confirming the effectiveness of the proposed MCMC-CA approach. [less ▲]

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See detailAnosognosia for behavioral disorder is related to confidence for false self-related memories in Alzheimer’s disease
Mélon, Marlène; Collette, Fabienne ULg; Salmon, Eric ULg et al

Poster (2017, March 24)

Impaired self-awareness (i.e. anosognosia) and altered metacognitive monitoring in memory tasks have both been evidenced in AD. Furthermore, cognitive studies showed disrupted interaction between self and ... [more ▼]

Impaired self-awareness (i.e. anosognosia) and altered metacognitive monitoring in memory tasks have both been evidenced in AD. Furthermore, cognitive studies showed disrupted interaction between self and memory cognitive systems in AD, reducing cognitive advantages of self-related memories (i.e. decreasing self reference effect, SRE) in these patients. However, how anosognosia relates to impaired metacognitive monitoring in AD, particularly for self-related memories, is still an open question. To investigate this question, an ecological memory task based on face-name associations was administrated to 20 healthy older controls (HC) and 20 mild AD patients. The influence of self-reference at encoding was assessed on subsequent name recall and recollective experience, as well as on predictive (feeling-of-knowing, FOK) and postretrieval (judgments-of-confidence, JOC) metacognitive judgments on name recognition in all participants. Furthermore relationships between metacognitive outcomes and awareness of daily cognitive and behavioral impairment was examined in AD. Altered SRE was evidenced in name recall and recollective experience in AD. Patients also showed impaired FOK and JOC, as well as lower awareness of their daily functioning impairment (anosognosia). Nevertheless, differential effect of self on metacognitive judgment in AD and HC was only observed on JOC for false memories. Importantly, anosognosia for behavioral disorders was related to post-retrieval confidence for false recognition of self-related items in AD patients. Thus, anosognosia concerning behavioral disorder and altered post-retrieval monitoring of self-related memories appear to be related in AD. We hypothesized that impaired monitoring of personal false memories may lead AD patients to rely on distorted recent reality when providing judgment about their everyday behavioral functioning. [less ▲]

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See detailDepression is a heterogeneous condition: A cluster-analysis approach
Wagener, Aurélie ULg; Baeyens, Céline; Van der Linden, Martial ULg et al

Poster (2017, March 24)

The heterogeneity of depression (i.e., symptomatology profiles, treatment responsiveness) is more and more evidenced. From a clinical perspective, having a clearer overview of the symptoms’ heterogeneity ... [more ▼]

The heterogeneity of depression (i.e., symptomatology profiles, treatment responsiveness) is more and more evidenced. From a clinical perspective, having a clearer overview of the symptoms’ heterogeneity of depression will help (1) to deeper understand its underlined psychological processes and (2) to tailor clinical treatments (i.e., psychological interventions and/or antidepressant medications). In order to so, an effort to determine subtypes of depression has been developed through a cluster-analysis approach. Andreasen et al. (1980) identified three clusters of depressed patients based on the Schedule for Affective Disorders and Schizophrenia; Schacht et al. (2014) evidenced five clusters based on the Hamilton Depression Rating Scale (i.e., lack of insight, sleep/sexual/somatic, typical MDD, gastrointestinal/weight loss, mild MDD); Hybels et al. (2012) found three clusters of depressive patients based on the Center for Epidemiologic Studies-Depression Scale in community seniors; and Guidi et al. (2011) found two clusters of depressives in medically ill patients based on the Structured Clinical Interview for DSM-IV (i.e., depressed somatizers, irritable/anxious depression). The current study aims at replicating and extending these previous findings in adults presenting depressive symptoms through a cluster-analysis approach. Unlike previous studies, the highlighting of the clusters will be based on the most frequently used assessment of depression, the Beck Depression Inventory-Second Edition (BDI-II). Further, the definition of the clusters will be based on the presence of the depressive symptoms rather than on their severity because symptoms’ severity on the BDI-II can be misrepresentative of the phenomenology of depressive symptoms’ clusters. A sample of 619 adults from community and mental healthcare centers has been recruited. Inclusion criteria were as follows: being a French-speaking adult aged between 18 and 60 years and presenting at least five symptoms on the BDI-II, irrespective of their severity. Data grouping was achieved through a combination of hierarchical (Ward’s method with squared Euclidian distance measurement) and nonhierarchical procedures (K-means cluster analysis), as recommended by recent theoretical trends. A six-cluster solution was evidenced: heavy sleepers (high levels of tiredness, loss of energy and increase of sleep), cognitive depressives (high levels of pessimism, past failures, guilty feelings, self-dislike and worthlessness), affective-somatic depressives (high levels of affective symptoms - loss of interest and pleasure - and somatic symptoms - increase of appetite and sleep, irritability), mild depressives (mild levels of all symptoms), sleepless depressives (high levels of decrease of sleep and tiredness), typical depressives (high levels of all symptoms). Results evidenced the heterogeneity of depressive symptoms, as six different clusters of depressive adults have been found. Two of the clusters identified in the current study are similar to two clusters identified by Schacht et al. (2014) (sleepless depressives are similar to the cluster “sleep/sexual/somatic” because their profile are highly characterized by symptoms related to insomnia and tiredness; mild depressives are similar to the cluster “mild MDD/symptoms” because their profile are characterized by low to average levels on all symptoms). The take-home message of this study is that depression is a heterogeneous condition. Consequently, it is necessary to consider this heterogeneity in order to tailor the psychological intervention. [less ▲]

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See detailIron minerals within specific microfossil morphospecies of the 1.88Ga Gunflint Formation
Lepot, kevin; Addad, Ahmed; Knoll, Andrew H et al

in Nature Communications (2017), DOI: 10.1038/ncomms14890

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See detailInterest of multisite bacterial screening for the diagnosis of congenital listerisosis with negative blood culture: a case report
Snyers, Diane ULg; Thirion, Sophie ULg; Kalenga, Masendu ULg et al

Scientific conference (2017, March 23)

Listeria monocytogenes (LM) is known to cause severe invasive disease in pregnant women and in newborns. Fortunately, despite the wide natural distribution of this pathogen, clinically overt neonatal ... [more ▼]

Listeria monocytogenes (LM) is known to cause severe invasive disease in pregnant women and in newborns. Fortunately, despite the wide natural distribution of this pathogen, clinically overt neonatal infections occurs rarely. As a consequence, listeriosis is not always considered for early onset neonatal infection, especially when blood culture is negative. Indeed, identification of listeria in the blood stream by conventional bacteriological methods remains the reference method for diagnosing listeriosis. We report a case of congenital listeriosis with negative blood culture despite typical chorioamnionitis, where the pathogen was cultured in gastric aspirate.Although the disease is rare, congenital listeriosis still remain a possible challenging condition in neonatal practice as revealed by this case report. This also shows the importance of multisite bacterial culture beside conventional blood and CSF culture, in combination with histological examination of the placenta for the diagnosis of congenital listeriosis. [less ▲]

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See detailL'E-sport : définition et contextualisation
Krywicki, Boris ULg

Conference given outside the academic context (2017)

Généralités et vulgarisation à propos du phénomène de "l'e-sport", le sport électronique.

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See detailUltimate strength of cylindrical shells with cutouts
Eui Lee, Sang; Sahin; Rigo, Philippe ULg et al

in Ships and Offshore Structures (2017)

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See detailKNN-MDR: a learning approach for improving interactions mapping performances in genome wide association studies
Abo Al Chamlat, Sinan ULg; Farnir, Frédéric ULg

in BMC Bioinformatics (2017), 18

Background Finding epistatic interactions in large association studies like genome-wide association studies (GWAS) with the nowadays-available large volume of genomic data is a challenging and largely ... [more ▼]

Background Finding epistatic interactions in large association studies like genome-wide association studies (GWAS) with the nowadays-available large volume of genomic data is a challenging and largely unsolved issue. Few previous studies could handle genome-wide data due to the intractable difficulties met in searching a combinatorial explosive search space and statistically evaluating epistatic interactions given a limited number of samples. Our work is a contribution to this field. We propose a novel approach combining K-Nearest Neighbors (KNN) and Multi Dimensional Reduction (MDR) methods for detecting gene-gene interactions as a possible alternative to existing algorithms, e especially in situations where the number of involved determinants is high. After describing the approach, a comparison of our method (KNN-MDR) to a set of the other most performing methods (i.e., MDR, BOOST, BHIT, MegaSNPHunter and AntEpiSeeker) is carried on to detect interactions using simulated data as well as real genome-wide data. Results Experimental results on both simulated data and real genome-wide data show that KNN-MDR has interesting properties in terms of accuracy and power, and that, in many cases, it significantly outperforms its recent competitors. Conclusions The presented methodology (KNN-MDR) is valuable in the context of loci and interactions mapping and can be seen as an interesting addition to the arsenal used in complex traits analyses. [less ▲]

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See detailInfluence of granular fraction and origin of recycled concrete aggregates on their properties
Zhao, Zengfeng ULg; Courard, Luc ULg; Michel, Frédéric ULg et al

in European Journal of Environmental and Civil Engineering (2017)

Large quantities of construction and demolition wastes are produced each year. In order to make good use of recycled concrete aggregates (RCA) in concrete, it is very important to study the influence of ... [more ▼]

Large quantities of construction and demolition wastes are produced each year. In order to make good use of recycled concrete aggregates (RCA) in concrete, it is very important to study the influence of the granular fraction and the origin of RCA on their properties. In this study, RCA from industrial produced blocks (RCA_Blocks) and slabs (RCA_Slabs) were crushed and then separated into four granular fractions (0/2, 2/6.3, 6.3/14, 14/20 mm). Each granular fraction of RCA was physically characterised. Real RCA from recycling plant were also used for comparison. The results showed that recycled sands offered significantly higher cement paste content (higher bound water content) than coarse recycled aggregates. The fine RCA had therefore a higher water absorption coefficient compared to coarser fractions of RCA. The water absorption of finer fraction of RCA could be extrapolated precisely from the relationship between water absorption and cement paste content (or bound water content) of three coarse fractions of RCA. The values of hardened cement paste content obtained for the RCA_Blocks were lower than those measured on the RCA_Slabs, which was due to a smaller amount of initial cement paste content in blocks. The results showed that RCA_Slabs were more angular than RCA_Blocks. [less ▲]

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See detailLichtenstein procedure under local anaesthesia
DETRY, Olivier ULg

Conference (2017, March 18)

LICHTENSTEIN REPAIR UNDER LOCAL ANAESTHESIA Pr Olivier Detry, Dpt of Abdominal Surgery and Transplantation, CHU Liège, Liège, Belgium. Email: oli.detry@chu.ulg.ac.be Despite many studies confirming the ... [more ▼]

LICHTENSTEIN REPAIR UNDER LOCAL ANAESTHESIA Pr Olivier Detry, Dpt of Abdominal Surgery and Transplantation, CHU Liège, Liège, Belgium. Email: oli.detry@chu.ulg.ac.be Despite many studies confirming the feasibility and the interest of local anaesthesia for inguinal hernia repair [1-3], its use is not generalized amongst abdominal surgeons. The advantages of local anaesthesia are indeed clear, including reduced costs, reduced hospital stay and reduced post operative pain. The success of the procedure depends on the skills and the motivation of the surgeon, of the nursing teams, and of the patient him/herself. Perfect knowledge of the surgical technique and of the regional nerve anatomy is required. The Lichtenstein repair may be easily performed under local anaesthesia, but should be proposed in the early experience to non-obese patients suffering from limited inguinal hernia. It can even be performed by surgical residents [4]. Practically, local anaesthesia requires some patience and quiet in the operative room. Operators should be aware that the action of local anaesthesia is delayed after injection. Local anaesthetics should be buffered [5] and at body temperature at time of injection. Local anaesthetics containing Adrenalin allow longer pain control, with limitation of bleeding and less toxicity. Large and brutal movements should be avoided. Transversus abdominis plane (TAP) block can also be proposed [6]. The surgical and anaesthetic techniques for inguinal hernia repair should be tailored to the specific characteristics of the hernia and of the patient. There is no method of choice that might fit for every patient. References [1] van Veen RN, Mahabier C, Dawson I, Hop WC, Kok NF, Lange JF, et al. Spinal or local anesthesia in lichtenstein hernia repair: a randomized controlled trial. Ann Surg 2008;247:428-433. [2] Verstraete L, Becaus N, Swannet H, Ceelen W, Duchateau L, Speybroeck N. Long term outcome after lichtenstein hernia repair using general, locoregional or local anaesthesia. Acta Chir Belg 2015;115:136-141. [3] Dhankhar DS, Sharma N, Mishra T, Kaur N, Singh S, Gupta S. Totally extraperitoneal repair under general anesthesia versus Lichtenstein repair under local anesthesia for unilateral inguinal hernia: a prospective randomized controlled trial. Surg Endosc 2014;28:996-1002. [4] Paajanen H, Varjo R. Ten-year audit of Lichtenstein hernioplasty under local anaesthesia performed by surgical residents. BMC Surg 2010;10:24. [5] Ball EL, Sanjay P, Woodward A. Comparison of buffered and unbuffered local anaesthesia for inguinal hernia repair: a prospective study. Hernia : the journal of hernias and abdominal wall surgery 2006;10:175-178. [6] Milone M, Di Minno MN, Musella M, Maietta P, Salvatore G, Iacovazzo C, et al. Outpatient inguinal hernia repair under local anaesthesia: feasibility and efficacy of ultrasound-guided transversus abdominis plane block. Hernia : the journal of hernias and abdominal wall surgery 2013;17:749-755. [less ▲]

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