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See detailLe manque de généralisation chez les enfants dysphasiques : une étude longitudinale
Leroy, Sandrine ULg; Parisse, Christophe; Maillart, Christelle ULg

in ANAE : Approche Neuropsychologique des Apprentissages chez l'Enfant (in press), 131

Usage-based theories postulate that development of linguistic system depends on a gradual generalization mechanism during which use of lexicalized language forms are little-by-little replaced by use of ... [more ▼]

Usage-based theories postulate that development of linguistic system depends on a gradual generalization mechanism during which use of lexicalized language forms are little-by-little replaced by use of abstract construction schemas. Several studies have shown limited morphosyntactic productivity in children with specific language impairment (SLI). In this longitudinal study, we have tested hypothesis according to which generalization would be hindered in children with SLI. [less ▲]

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See detailRéflexions autour des principes de rééducation proposés aux enfants dysphasiques
Maillart, Christelle ULg; Desmottes, Lise ULg; Prigent, Gaïd ULg et al

in ANAE : Approche Neuropsychologique des Apprentissages chez l'Enfant (in press), 131

This paper addresses the principles used in efficient language intervention. These principles will be examined in the light of recent data in typical and atypical language development. Particular ... [more ▼]

This paper addresses the principles used in efficient language intervention. These principles will be examined in the light of recent data in typical and atypical language development. Particular attention will be given to repetition and variability, in link with recent theoretical framework about language development. [less ▲]

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See detailgammaMAXT: a fast multiple-testing correction algorithm
Van Lishout, François ULg; Gadaleta, Francesco ULg; Moore, Jason H. et al

in ERCIM 2014 Abstract Book (in press)

The purpose of the maxT algorithm (1993) is to control the family-wise error rate (FWER) when assessing significance of multiple tests jointly. However, the requirements in terms of computing time and ... [more ▼]

The purpose of the maxT algorithm (1993) is to control the family-wise error rate (FWER) when assessing significance of multiple tests jointly. However, the requirements in terms of computing time and memory of this procedure are proportional to the number of investigated hypothesis. The memory issue has been solved by Van Lishout’s implementation of maxT (2013), which makes the memory usage independent from the size of the dataset. This algorithm is implemented in MBMDR-3.0.3, a software that is able to identify genetic interactions, for a variety of SNP-SNP based epistasis model,s in an effective way. However, that implementation turned out to be less suitable for genome-wide interaction analysis studies, due to the prohibitive computational burden. Here, we present gammaMAXT, a novel algorithm which is part of MBMDR-4.2.2. We show that, in the abscence of interaction effects, test-statistics produced by the MB-MDR methodology follow a mixture distribution with a point mass at zero and a shifted gamma distribution for the top 10% of the strictly positive values. We show that the gammaMAXT algorithm has a power comparable to maxT and maintains FWER, but requires less computational resources and time. MBMDR-4.2.2 can be downloaded at http://www.statgen.ulg.ac.be. [less ▲]

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See detailLa richesse du sensible: Stumpf contre les néokantiens
Dewalque, Arnaud ULg

in Calori, François; Foessel, Michael; Pradelle, Dominique (Eds.) De la Sensibilité: les Esthétiques de Kant (in press)

Me focalisant sur la réception de l'esthétique transcendantale de Kant en Allemagne à la fin du XIXe et au début du XXe siècle, je confronte deux lectures concurrentes du kantisme: la lecture ... [more ▼]

Me focalisant sur la réception de l'esthétique transcendantale de Kant en Allemagne à la fin du XIXe et au début du XXe siècle, je confronte deux lectures concurrentes du kantisme: la lecture "déflationiste" des néokantiens, qui aboutit à une conception appauvrie du sensible, et la lecture "inflationiste" de Stumpf, qui fait du sensible un champ richement et intrinsèquement structuré. [less ▲]

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See detailJules Destrée animateur de la vie littéraire
Dozo, Björn-Olav ULg

in Institut Destrée (Ed.) Centenaire de la Lettre au Roi de Jules Destrée (in press)

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See detailChronos et la clé du temps
Désert, Jean-Benoît ULg; Charon, valérie; Triffaux, Jean-Marc ULg

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (in press), 15(15), 79-85

L’argument de ce XLème Colloque des Hôpitaux de jour psychiatriques nous a plongés dans un abîme de questionnements théoriques et pratiques. Défiés par cette immersion dans les tréfonds du modèle, nous ... [more ▼]

L’argument de ce XLème Colloque des Hôpitaux de jour psychiatriques nous a plongés dans un abîme de questionnements théoriques et pratiques. Défiés par cette immersion dans les tréfonds du modèle, nous avons choisi de nous accrocher aux fondements de notre univers. La mythologie grecque sera donc notre source d’inspiration en mettant un dieu antique à notre disposition. Chronos sera notre guide dans un périple réflexif soumettant nos théories et notre pratique à l’épreuve du temps. Le récit de la conception d’un atelier thérapeutique, l’atelier « Art & Temps », sera notre fil d’Ariane dans notre tentative de symboliser notre pratique thérapeutique quotidienne et ses enjeux. Par la suite, l’exposé d’un cas clinique concrétisera un raisonnement théorique visant à situer notre modèle de prise en charge dans le réseau psychiatrique global. [less ▲]

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See detailSedimentological and geochemical evidence to detect arid periods recorded in wadi deposits: a case study from northern Morocco
El Ouahabi, Meriam ULg; Bartz, Melanie; Rixhon, Gilles et al

Poster (2015, July 27)

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See detailPaleoseismological record of the Hazar Lake along the East Anatolian Fault (Turkey)
Hubert, Aurelia ULg; Lamair, Laura ULg; Hage, Sophie et al

Poster (2015, July 27)

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See detailBiogeographic variations in wood mice: Testing for the role of morphological variation as a line of least resistance to evolution
Renaud, Sabrina; Quere, Jean Pierre; Michaux, Johan ULg

in Cox, Philippe; Hautier, Lionel (Eds.) Cambridge Studies in Morphology and Molecules: New Paradigms in Evolutionary Biology ‘Evolution of the Rodents: Advances in Phylogeny, Paleontology and Functional Morphology’ (2015)

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See detailPrésentation de cas pratique - atelier n°2 « Outils et méthodes de formation : quels outils (EAD, MOOC, partage social, manuels...) et quelles méthodes (enseignement mixte, classe inversée, résolution de problèmes, travaux en groupe...) face à des groupes de tailles très variables ? Comment former avec peu de moyens (financiers, humains, matériels) ? »
Pasquet, Coralie ULg

Conference (2015, May 18)

Au cours du premier quadrimestre de l’année académique 2014 - 2015, une nouvelle activité a été proposée aux 280 étudiants inscrits en 3ième année du grade de Bachelier en Médecine à ... [more ▼]

Au cours du premier quadrimestre de l’année académique 2014 - 2015, une nouvelle activité a été proposée aux 280 étudiants inscrits en 3ième année du grade de Bachelier en Médecine à l’Université de Liège, ce dans le cadre du « Module Système Nerveux ». La réalisation progressive de cette activité s'est effectuée exclusivement en ligne. [less ▲]

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See detailImpact of Aphasia on Consciousness Assessment: A Cross-Sectional Study.
Schnakers, C; Bessou, H; Rubi-Fessen, I et al

in Neurorehabilitation & Neural Repair (2015), 29

BACKGROUND: . Previous findings suggest that language disorders may occur in severely brain-injured patients and could interfere with behavioral assessments of consciousness. However, no study ... [more ▼]

BACKGROUND: . Previous findings suggest that language disorders may occur in severely brain-injured patients and could interfere with behavioral assessments of consciousness. However, no study investigated to what extent language impairment could affect patients' behavioral responses. OBJECTIVE: . To estimate the impact of receptive and/or productive language impairments on consciousness assessment. METHODS: . Twenty-four acute and subacute stroke patients with different types of aphasia (global, n = 11; Broca, n = 4; Wernicke, n = 3; anomic, n = 4; mixed, n = 2) were recruited in neurology and neurosurgery units as well as in rehabilitation centers. The Coma Recovery Scale-Revised (CRS-R) was administered. RESULTS: . We observed that 25% (6 out of 24) of stroke patients with a diagnosis of aphasia and 54% (6 out of 11) of patients with a diagnosis of global aphasia did not reach the maximal CRS-R total score of 23. An underestimation of the consciousness level was observed in 3 patients with global aphasia who could have been misdiagnosed as being in a minimally conscious state, even in the absence of any documented period of coma. More precisely, lower subscores were observed on the communication, motor, oromotor, and arousal subscales. CONCLUSION: . Consciousness assessment may be complicated by the co-occurrence of severe language deficits. This stresses the importance of developing new tools or identifying items in existing scales, which may allow the detection of language impairment in severely brain-injured patients. [less ▲]

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See detailThe words of prevention, part II: ten terms in the realm of quaternary prevention
Jamoulle, Marc ULg; Gavilan, Enrique; Cardoso, Raquel Val et al

in Revista Brasileira de Medicina de Família e Comunidade (2015)

ABSTRACT Objective: This part II article about the ‘words of prevention’ presents in a terminological way the content of ten current concepts used in the prevention domain which are closely linked to ... [more ▼]

ABSTRACT Objective: This part II article about the ‘words of prevention’ presents in a terminological way the content of ten current concepts used in the prevention domain which are closely linked to quaternary prevention: (1) overinformation, (2) overdiagnosis, (3) medically unexplained symptoms, (4) overmedicalisation, (5) incidentaloma, (6) overscreening, (7) overtreatment, (8) shared decision making, (9) deprescribing, and (10) disease mongering. Methods: with the support of the laboratory team of the University of Rouen, France, which is dedicated to medical terminology and semantic relationships, it was possible to utilize a graphic user interface (called DBGUI) allowing the construction of links for each of chosen terms, and making automatic links to MeSH, if any. Those concepts are analyzed in their environment in current literature, as well as in their MeSH counterparts, if any, and related semantic online terminologies. Results and Discussion: The rules in terminological development aspire to cover the whole field of a concept and in the meantime, it helps to avoid the noise due to proxy and not exactly related issues. This refers to exhaustivity and specificity in information retrieval. Our finds show that referring to MeSH only in information retrieval in General Practice/Family medicine can induce much noise and poor adequacy to the subject investigated. Conclusion: Gathering concepts in specially prepared terminologies for further development of ontologies is a necessity to enter in the semantic web area and the era of distributed data. [less ▲]

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See detailThe words of prevention, part I: changing the model
Jamoulle, Marc ULg; Gavilan, Enrique; Cardoso, Raquel Val et al

in Revista Brasileira de Medicina de Família e Comunidade (2015)

ABSTRACT Objective: This part I article explores the different meanings of relevant keywords for General Practice/Family Medicine (GP/FM) in the prevention domain. The aim is to contribute to information ... [more ▼]

ABSTRACT Objective: This part I article explores the different meanings of relevant keywords for General Practice/Family Medicine (GP/FM) in the prevention domain. The aim is to contribute to information process in GP/FM by keeping in line with the main terms used in health care organization. Methods: Important keywords for GP/FM in the prevention domain were selected. Then, a search was carried out on the main sources in GP/FM databases, as well as in Medical Subject Heading and major terminological databases available online. Results and Discussion: There is discrepancy between the conceptual contents of major prevention models amongst the usual bibliographic sources of knowledge in GP/FM in particular and medicine in general. Conclusion: For GP/FM, distribution of preventive activities is now firmly established on a new constructivist model, privileging the doctor-patient relationships and introducing a cybernetic thinking on the health care activities with a special commitment to ethics and the positive duty of beneficence. [less ▲]

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See detailPrevenção quaternária: primeiro não causar dano - Editorial
Jamoulle, Marc ULg

in Revista Brasileira de Medicina de Família e Comunidade (2015)

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See detailQuaternary prevention: first, do not harm - Editorial
Jamoulle, Marc ULg

in Revista Brasileira de Medicina de Família e Comunidade (2015)

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See detailLa collaboration entre différentes disciplines médicales : ou est le problème ? Etude Partnership in Medicine
Vanmeerbeek, Marc ULg; Govers, Patrick ULg; Schippers, Nathalie ULg et al

Conference (2015, March 27)

Objectifs Les maladies ou problèmes médicaux d’origine professionnelle, ou en lien avec le travail, impliquent à des degrés divers les médecins généralistes (MG), les médecins du travail (MT) et les ... [more ▼]

Objectifs Les maladies ou problèmes médicaux d’origine professionnelle, ou en lien avec le travail, impliquent à des degrés divers les médecins généralistes (MG), les médecins du travail (MT) et les médecins-conseils des mutuelles (MC). Le manque de relation fonctionnelle entre eux peut compliquer ou retarder le retour au travail du patient. L’étude cherchait des pistes d’amélioration de la collaboration. Méthode Deux méthodes de consensus ont été successivement utilisées parmi les trois professions : huit groupes nominaux (GN) ont réunis 74 médecins de terrain; deux rondes Delphi ont concerné 28 décideurs. Résultats Un seul médecin a été perdu de vue entre les 2 tours du Delphi. Les propositions issues des GN concernaient le transfert d’informations (surtout les MT et les MC), la collaboration (surtout les MG et les MT), les connaissances, et le cadre légal et réglementaire (surtout les MC). Cinq questions sur 14 n’ont pas fait consensus (≥75%) au 1er tour du Delphi, et 10 propositions sur 13 ont été rejetées au 2e tour. Les désaccords portaient sur la nature des données à transférer, les modalités de transfert d’information, la disponibilité des données de contact des médecins. Un processus d’évitement spécifique a été mis en évidence. Certains commentaires montraient un déni de la capacité des autres à comprendre son champ professionnel, et une difficulté à considérer leur spécificité propre. Conclusions L’étude montre que le patient n’est pas un objet partagé de la relation. Le modèle Resource Dependence Institutional Cooperation (De Rijk) permet de distinguer les entraves à la volonté de coopérer (dépendance perçue) des limitations dans la capacité à le faire (manque de ressources). Le modèle quadridimensionnel de la collaboration (D’Amour) identifie un déficit d’internalisation du côté relationnel (reconnaissance des autres), et un déficit de gouvernance et de formalisation du côté organisationnel, où des initiatives volontaristes des autorités seraient bienvenues. [less ▲]

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See detailBioassessment of trace element contamination of Mediterranean coastal waters using the seagrass Posidonia oceanica
Richir, Jonathan ULg; Salivas-Decaux, Maÿlis; Lafabrie, Céline et al

in Journal of Environmental Management (2015), 150

A large scale survey of the trace element (TE) contamination of Mediterranean coastal waters was performed from the analysis of Ag, As, Cd, Cu, Hg, Ni and Pb in the bioindicator Posidonia oceanica ... [more ▼]

A large scale survey of the trace element (TE) contamination of Mediterranean coastal waters was performed from the analysis of Ag, As, Cd, Cu, Hg, Ni and Pb in the bioindicator Posidonia oceanica, sampled at 110 sites differing by their levels of exposure to contaminants. The holistic approach developed in this study, based on the combined utilization of several complementary monitoring tools, i.e. water quality scale, pollution index and spatial analysis, accurately assessed the TE contamination rate of Mediterranean coastal waters. In particular, the mapping of the TE contamination according to a new proposed 5-level water quality scale precisely outlined the contamination severity along Mediterranean coasts and facilitated interregional comparisons. Finally, the reliability of the use of P. oceanica as bioindicator species was again demonstrated through several global, regional and local detailed case studies. NB: The designations employed and the presentation of the information in thisdocument do not imply the expression of any opinion whatsoever on the part of the authors concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. [less ▲]

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See detailHow well can cold dark matter substructures account for the observed radio flux-ratio anomalies
Xu, Dandan; Sluse, Dominique ULg; Gao, Liang et al

in Monthly Notices of the Royal Astronomical Society (2015), 447

Discrepancies between the observed and model-predicted radio flux ratios are seen in a number of quadruply-lensed quasars. The most favoured interpretation of these anomalies is that cold dark matter (CDM ... [more ▼]

Discrepancies between the observed and model-predicted radio flux ratios are seen in a number of quadruply-lensed quasars. The most favoured interpretation of these anomalies is that cold dark matter (CDM) substructures present in lensing galaxies perturb the lens potentials and alter image magnifications and thus flux ratios. So far no consensus has emerged regarding whether or not the predicted CDM substructure abundance fully accounts for the lensing flux anomaly observations. Accurate modelling relies on a realistic lens sample in terms of both the lens environment and internal structures and substructures. In this paper, we construct samples of generalized and specific lens potentials, to which we add (rescaled) subhalo populations from the galaxy-scale Aquarius and the cluster-scale Phoenix simulation suites. We further investigate the lensing effects from subhaloes of masses several orders of magnitude below the simulation resolution limit. The resulting flux-ratio distributions are compared to the currently best available sample of radio lenses. The observed anomalies in B0128+437, B0712+472 and B1555+375 are more likely to be caused by propagation effects or oversimplified/improper lens modelling, signs of which are already seen in the data. Among the quadruple systems that have closely located image triplets/pairs, the anomalous flux ratios of MG0414+0534 can be reproduced by adding CDM subhaloes to its macroscopic lens potential, with a probability of 5-20 per cent; for B0712+472, B1422+231, B1555+375 and B2045+265, these probabilities are only of a few per cent. We hence find that CDM substructures are unlikely to be the whole reason for radio flux anomalies. We discuss other possible effects that might also be at work. [less ▲]

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