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See detailArrêt(s) sur image(s) : usages et pratiques du photogramme
Thonon, Jonathan ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (in press)

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See detailMyelofibrosis patients in Belgium: disease characteristics
Devos, Timothy; Zachée, Pierre; Bron, Domonique et al

in Acta Clinica Belgica (in press)

Objective: To date, only a small number of epidemiological studies on myelofibrosis have been performed. The current study aimed to characterize the myelofibrosis patient population in Belgium according ... [more ▼]

Objective: To date, only a small number of epidemiological studies on myelofibrosis have been performed. The current study aimed to characterize the myelofibrosis patient population in Belgium according to predefined disease parameters (diagnosis, risk categories, hemoglobin ,10 g/dl, spleen size, constitutional symptoms, platelet count, myeloblast count), with a view to obtaining a deeper understanding of the proportion of patients that may benefit from the novel myelofibrosis therapeutic strategies. Methods: A survey was used to collect data on prevalence and disease parameters on all myelofibrosis patients seen at each of 18 participating hematologic centers in 2011. Aggregated data from all centers were used for analysis. Analyses were descriptive and quantitative. Results: A total of 250 patients with myelofibrosis were captured; of these, 136 (54%) were male and 153 (61%) were over 65 years old. One hundred sixty-five (66%) of myelofibrosis patients had primary myelofibrosis and 85 (34%) had secondary myelofibrosis. One hundred ninety-three myelofibrosis patients (77%) had a palpable spleen. About a third of patients (34%) suffered from constitutional symptoms. Two hundred twenty-two (89%) myelofibrosis patients had platelet count§50 000/ml and 201 (80%) had platelet count §100 000/ml. Of 250 patients, 85 (34%) had a myeloblast count §1%. Six (2%) patients had undergone a splenectomy. Thirteen (5.2%) patients had undergone radiotherapy for splenomegaly. Conclusions: The results of this survey provide insight into the characteristics of the Belgian myelofibrosis population. They also suggest that a large proportion of these patients could stand to benefit from the therapies currently under development. [less ▲]

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See detailAnother Generalization of Abelian Equivalence: Binomial Complexity of Infinite Words (long version)
Rigo, Michel ULg; Salimov, Pavel

in Theoretical Computer Science (in press)

The binomial coefficient of two words $u$ and $v$ is the number of times $v$ occurs as a subsequence of $u$. Based on this classical notion, we introduce the $m$-binomial equivalence of two words refining ... [more ▼]

The binomial coefficient of two words $u$ and $v$ is the number of times $v$ occurs as a subsequence of $u$. Based on this classical notion, we introduce the $m$-binomial equivalence of two words refining the abelian equivalence. Two words $x$ and $y$ are $m$-binomially equivalent, if, for all words $v$ of length at most $m$, the binomial coefficients of $x$ and $v$ and respectively, $y$ and $v$ are equal. The $m$-binomial complexity of an infinite word $x$ maps an integer $n$ to the number of $m$-binomial equivalence classes of factors of length $n$ occurring in $x$. We study the first properties of $m$-binomial equivalence. We compute the $m$-binomial complexity of two classes of words: Sturmian words and (pure) morphic words that are fixed points of Parikh-constant morphisms like the Thue--Morse word, i.e., images by the morphism of all the letters have the same Parikh vector. We prove that the frequency of each symbol of an infinite recurrent word with bounded $2$-binomial complexity is rational. [less ▲]

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See detailThe utility of Google Scholar when searching geographical literature: comparison with three commercial bibliographic databases
Stirbu, Simona ULg; Thirion, Paul ULg; Schmitz, Serge ULg et al

in Journal of Academic Librarianship (in press)

This study aims to highlight what benefits, if any, Google Scholar (GS) has for academic literature searches in the field of geography, compared to three commercial bibliographic databases: Web of Science ... [more ▼]

This study aims to highlight what benefits, if any, Google Scholar (GS) has for academic literature searches in the field of geography, compared to three commercial bibliographic databases: Web of Science (WoS) and FRANCIS (multidisciplinary databases) and GeoRef (specialized in geosciences). To ensure a valid comparison, identical bibliographic searches were applied using each of the four bibliographic tools. To exclude automatic variations of the ten keywords tested, they were placed between quotation marks and searched only in the “title” field of the respective search tools’ interfaces. The results were limited to bibliographic references published from 2005 to 2009. In order to assess the repeatability of the results, the exact same process was repeated monthly between November 2010 and July 2011. Initially the whole set of results was analyzed, after which the search results for two keywords (selected since they yielded a manageable number of results) were studied in more detail. The results indicate that GS search results show a large degree of overlap with those of the other databases but, moreover, yield numerous unique hits, which should be useful to researchers in both the fields of human and physical geography. GS leads the other tools widely on number of results, independently of keyword, subfield, year of publication, or time of search. [less ▲]

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See detailTowards a framework for assessment and management of cumulative human impacts on marine food webs
Giakoumi, Sylvaine; Halpern, Benjamin S.; Michel, Loïc ULg et al

in Conservation Biology (in press)

Effective ecosystem-based management requires understanding ecosystem responses to multiple human threats, rather than focusing on single threats. To understand ecosystem responses to anthropogenic ... [more ▼]

Effective ecosystem-based management requires understanding ecosystem responses to multiple human threats, rather than focusing on single threats. To understand ecosystem responses to anthropogenic threats holistically, it is necessary to know how threats affect different components within ecosystems and ultimately alter ecosystem functioning. We used a case study of a Mediterranean seagrass (Posidonia oceanica) food web and expert knowledge elicitation in an application of the initial steps of a framework for assessment of cumulative human impacts on food webs. We produced a conceptual seagrass food web model, determined the main trophic relationships, identified the main threats to the food web components, and assessed the components’ vulnerability to those threats. Some threats had high (e.g., coastal infrastructure) or low impacts (e.g., agricultural runoff) on all food web components, whereas others (e.g., introduced carnivores) had very different impacts on each component. Partitioning the ecosystem into its components enabled us to identify threats previously overlooked and to reevaluate the importance of threats commonly perceived as major. By incorporating this understanding of system vulnerability with data on changes in the state of each threat (e.g., decreasing domestic pollution and increasing fishing) into a food web model, managers may be better able to estimate and predict cumulative human impacts on ecosystems and to prioritize conservation actions. [less ▲]

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See detailWhat do Pneumocystis organisms tell us about the phylogeography of their hosts? The case of the woodmouse Apodemus sylvaticus in continental Europe and western Mediterranean islands
Demanche, christine; Deville, Manjula; Michaux, Johan ULg et al

in PLoS ONE (in press)

Pneumocystis fungi represent a highly diversified biological group with numerous species, which display a strong host-specificity suggesting a long co-speciation process. In the present study, the ... [more ▼]

Pneumocystis fungi represent a highly diversified biological group with numerous species, which display a strong host-specificity suggesting a long co-speciation process. In the present study, the presence and genetic diversity of Pneumocystis organisms was investigated in 203 lung samples from woodmice (Apodemus sylvaticus) collected on western continental Europe and Mediterranean islands. The presence of Pneumocystis DNA was assessed by nested PCR at both large and small mitochondrial subunit (mtLSU and mtSSU) rRNA loci. Direct sequencing of nested PCR products demonstrated a very high variability among woodmouse-derived Pneumocystis organisms with a total number of 30 distinct combined mtLSU and mtSSU sequence types. However, the genetic divergence among these sequence types was very low (up to 3.87%) and the presence of several Pneumocystis species within Apodemus sylvaticus was considered unlikely. The analysis of the genetic structure of woodmouse-derived Pneumocystis revealed two distinct groups. The first one comprised Pneumocystis from woodmice collected in continental Spain, France and Balearic islands. The second one included Pneumocystis from woodmice collected in continental Italy, Corsica and Sicily. These two genetic groups were in accordance with the two lineages currently described within the host species Apodemus sylvaticus. Pneumocystis organisms are emerging as powerful tools for phylogeographic studies in mammals [less ▲]

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See detailAn Ant Colony System for Responsive Dynamic Vehicle Routing
Schyns, Michael ULg

in European Journal of Operational Research (in press)

We present an algorithm based on an Ant Colony System to deal with a broad range of Dynamic Capacitated Vehicle Routing Problems with Time Windows, (partial) Split Delivery and Heterogeneous fleets ... [more ▼]

We present an algorithm based on an Ant Colony System to deal with a broad range of Dynamic Capacitated Vehicle Routing Problems with Time Windows, (partial) Split Delivery and Heterogeneous fleets (DVRPTWSD). Besides the traditional distance criterion, we address the important case of responsiveness. Responsiveness is defined here as completing a delivery as soon as possible, within the time window, such that the client or the truck may restart its activities. This is crucial for many production or service activities in different fields: express parcel deliveries, taxi services, Just in Time production, express repair services, medical care, petrol station replenishment, etc. We develop an interactive web-based solution to allow dispatchers to take new information into account in real-time. The algorithm and its parametrization were tested on real and artificial instances. We first illustrate our approach with a problem submitted by Liege Airport, the 8th biggest cargo airport in Europe. The goal is to develop a decision system to optimize the journey of the refueling trucks. We then consider some classical VRP benchmarks with extensions for more complex problems. [less ▲]

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See detailLa question du diagnostic en psychiatrie infanto-juvénile
de Becker, Emmanuel; François, Anne; Kinoo, Philippe et al

in Psychiatrie de l'Enfant (La) (in press)

Dans le vaste champ de l’aide et des soins à l’égard de l’enfant et de l’adolescent, les questions liées au diagnostic transcendent souvent les aspects de prises en charge et de liens thérapeutiques ainsi ... [more ▼]

Dans le vaste champ de l’aide et des soins à l’égard de l’enfant et de l’adolescent, les questions liées au diagnostic transcendent souvent les aspects de prises en charge et de liens thérapeutiques ainsi que les multiples échanges entre professionnels concernés. Le diagnostic pédopsychiatrique est un processus dynamique, modifiable et momentané, les organisations pathologiques étant pour la plupart en transformation permanente. De manière spécifique et en fonction du processus développemental, la thématique du diagnostic en pédopsychiatrie renvoie plus à la question du risque évolutif qu’à la question d’un état pathologique en soi. Les aspects de la continuité des troubles mentaux de l’enfance à l’âge adulte représentent en effet un véritable enjeu développemental. Deux points de vue s’opposent dans la littérature. Le premier, en lien avec un prédéterminisme, estime que les trajectoires sont toutes tracées, l’incertitude reposant dans le diagnostic ; concrètement, il s’agit de repérer de manière précoce des individus à risque parce qu’ils sont porteurs d’un trouble qu’il faut traiter. Le second point de vue considère que les trajectoires ne sont pas déterminées mais sont en réécriture permanente ; ici, le risque ne se situe plus au niveau du diagnostic mais du pronostic, dans un souci de prévention et non de prédiction. L’article propose les réflexions de quatre cliniciens psychiatres infanto-juvéniles sur cette thématique, à la lumière de leur pratique et de leurs échanges. [less ▲]

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See detailElectrical characterization of p-GeSn/n-Ge diodes with interface traps under dc and ac regimes
Baert, Bruno ULg; Gupta, Somya; Gencarelli, Federica et al

in Solid-State Electronics (in press)

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See detailPhénoménologie autrichienne: le programme de Brentano
Dewalque, Arnaud ULg

in Austriaca (in press)

It is usual to think of the spectacular development of the Brentano School in Austria as being tied to the rise of a specific research program, which is sometimes dubbed “Austrian phenomenology”. I ... [more ▼]

It is usual to think of the spectacular development of the Brentano School in Austria as being tied to the rise of a specific research program, which is sometimes dubbed “Austrian phenomenology”. I discuss here some evidences for the existence of such a program. In the discussion, I highlight two claims which I take to be constitutive of the Brentanian phenomenology. The first one is the epistemological claim according to which our concepts all have an empirical origin, which has to be located in the experience we have of our own mental states. The second one is the methodological claim according to which describing a mental phenomenon P is nothing but analysing P, where “analysing P” simply means “distinctly perceiving all the constituents of P”. Although a deeper insight in those two claims would require considerable further investigations, I suggest they should be part of the picture when it comes to adjudicating on the specificity of the Brentanian program. [less ▲]

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See detailLandesbeitrag Belgien : Wesen und Gestalt der Verfassungsgerichtsbarkeit in Belgien
Behrendt, Christian ULg

in von Bogdandy, Armin; Grabenwarter, Christoph; Huber, Peter M. (Eds.) Ius Publicum Europaeum - Band VI - Verfassungsgerichtsbarkeit (in press)

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See detailActive Management of Low-Voltage Networks for Mitigating Overvoltages due to Photovoltaic Units
Olivier, Frédéric ULg; Aristidou, Petros ULg; Ernst, Damien ULg et al

in IEEE Transactions on Smart Grid (in press)

In this paper, the overvoltage problems that might arise from the integration of photovoltaic panels into low-voltage distribution networks is addressed. A distributed scheme is proposed that adjusts the ... [more ▼]

In this paper, the overvoltage problems that might arise from the integration of photovoltaic panels into low-voltage distribution networks is addressed. A distributed scheme is proposed that adjusts the reactive and active power output of inverters to prevent or alleviate such problems. The proposed scheme is model-free and makes use of limited communication between the controllers, in the form of a distress signal, only during emergency conditions. It prioritizes the use of reactive power, while active power curtailment is performed only as a last resort. The behavior of the scheme is studied using dynamic simulations on a single low-voltage feeder and on a larger network composed of 14 low-voltage feeders. Its performance is compared to a centralized scheme based on the solution of an Optimal Power Flow problem, whose objective function is to minimize the active power curtailment. The proposed scheme successfully mitigates overvoltage situations due to high photovoltaic penetration and performs almost as well as the Optimal Power Flow based solution with significantly less information and communication requirements. [less ▲]

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See detailLate Pleistocene molecular dating of past population fragmentation and demographic changes in African rain forest tree species supports the forest refuge hypothesis
Duminil, Jérôme; Mona, Stefano; Mardulyn, Patrick et al

in Journal of Biogeography (in press)

Aim : Phylogeographical signatures of past population fragmentation and demographic change have been reported in several African rain forest trees. These signatures have usually been interpreted in the ... [more ▼]

Aim : Phylogeographical signatures of past population fragmentation and demographic change have been reported in several African rain forest trees. These signatures have usually been interpreted in the light of the Pleistocene forest refuge hypothesis, although dating these events has remained impracticable because of inadequate genetic markers. We assess the timing of interspecific and intraspecific genetic differentiation and demographic changes within two rain forest Erythrophleum tree species (Fabaceae: Caesalpinioideae). Location : Tropical forests of Upper Guinea (West Africa) and Lower Guinea (Atlantic Central Africa). Methods : Six single-copy nuclear genes were used to characterize the phylogeographical patterns of the parapatric sister species Erythrophleum suaveolens (characteristic of semi-deciduous or gallery forests) and Erythrophleum ivorense (characteristic of evergreen forests). The number of gene pools within each species was determined and the timings of their divergence and past demographic changes were estimated using Bayesian-based coalescent approaches. Results : Three geographically separated gene pools were identified within E. suaveolens, and a single gene pool was inferred in E. ivorense. All gene pools show signatures of demographic bottlenecks concomitant with the last glacial period (c. 120–12 ka). Species-tree inferences show that the two species diverged c. 600 ka, whereas the divergence between E. suaveolens gene pools was dated to the late Pleistocene (first divergence c. 120 ka, second c. 60 ka). Main conclusions : (1) Molecular dating of demographic changes of two African tropical forest tree species is consistent with the Pleistocene forest refuge hypothesis. (2) Tree species from Guinean evergreen tropical forests might have been less affected by past climate change than semi-deciduous species. (3) Our phylogeographical data support a recent date (Holocene) of the last opening of the Dahomey Gap. [less ▲]

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See detailNewt life after fish introduction: extirpation of paedomorphosis in a mountain fish lake and newt use of satellite pools
Denoël, Mathieu ULg; Scime, Patrick; Zambelli, Nicola

in Current Zoology (in press), 62

Fish introduction is one of the main causes of amphibian decline worldwide. It affects particularly rare aquatic phenotypes such as paedomorphs, which retain gills during the adult stage. In this context ... [more ▼]

Fish introduction is one of the main causes of amphibian decline worldwide. It affects particularly rare aquatic phenotypes such as paedomorphs, which retain gills during the adult stage. In this context, we determined whether small wetlands, such as pools surrounding fished and fishless lakes, could sustain paedomorphic and metamorphic newts. To this end, we surveyed lakes known historically to sustain Alpine newts (Ichthyosaura alpestris) as well as 35 nearby pools. On the basis of the published records, the only known population exhibiting paedomorphosis in the Swiss Alps was found to be extirpated by salmonid introductions. However, the metamorphs persisted in peripheral pools, paedomorphosis was discovered at a new locality, and overwintering larvae were still present in one of the lakes. These results show the importance of conserving varied aquatic habitats such as pools in mountainous environments where the main resources can become unsuitable for amphibians because of fish introductions. Pools may also function as reservoirs in maintaining newt populations until programs to remove fish from lakes can be carried out. It is not known if paedomorphs could reappear after fish removal. However, the combined resilience of amphibians after fish removal and the genetic basis for paedomorphosis highlighted in other taxa by previous studies suggest that there is the potential to maintain this intraspecific case of diversity even after its disappearance. [less ▲]

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See detailImmune Recovery after Allogeneic Hematopoietic Stem Cell Transplantation following Flu-TBI versus TLI-ATG Conditioning
HANNON, Muriel ULg; BEGUIN, Yves ULg; Ehx, Grégory ULg et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (in press)

Purpose: A conditioning regimen for allogeneic hematopoietic cell transplantation (HCT) combining total lymphoid irradiation (TLI) plus anti-thymocyte globulin (ATG) has been develop to induce graft ... [more ▼]

Purpose: A conditioning regimen for allogeneic hematopoietic cell transplantation (HCT) combining total lymphoid irradiation (TLI) plus anti-thymocyte globulin (ATG) has been develop to induce graft-versus-tumor effects without graft-versus-host disease (GVHD). Experimental Design: We compared immune recovery in 53 patients included in a phase II randomized study comparing nonmyeloablative HCT following either fludarabine plus 2 Gy total body irradiation (TBI arm, n=28) or 8 Gy TLI plus anti-thymocyte globulin (TLI arm, n=25). Results: In comparison to TBI patients, TLI patients had a similarly low 6-month incidence of grade II-IV acute GVHD, a lower incidence of moderate/severe chronic GVHD (P=0.02), a higher incidence of CMV reactivation (P<0.001), and a higher incidence of relapse (P=0.01). While recovery of total CD8+ T cells was similar in the two groups, with median CD8+ T cell counts reaching the normal values 40-60 days after allo-HCT, TLI patients had lower percentages of naïve CD8 T cells. Median CD4+ T cell counts did not reach the lower limit of normal values the first year after allo-HCT in the two groups. Further, CD4+ T cell counts were significantly lower in TLI than in TBI patients the first 6 months after transplantation. Interestingly, while median absolute regulatory T cell (Treg) counts were comparable in TBI and TLI patients, Treg/naïve CD4+ T cell ratios were significantly higher in TLI than in TBI patients the 2 first years after transplantation. Conclusions: Immune recovery differs substantially between these two conditioning regimens possibly explaining the different clinical outcomes observed (NCT00603954). [less ▲]

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See detailNeural correlates of personal goal processing during episodic future thinking and mind-wandering: an ALE meta-analysis
Stawarczyk, David ULg; D'Argembeau, Arnaud ULg

in Human Brain Mapping (in press)

The ability to imagine the future is a complex mental faculty that depends on an ensemble of cognitive processes supported by an extended set of brain regions. Our aim here was to shed light on one key ... [more ▼]

The ability to imagine the future is a complex mental faculty that depends on an ensemble of cognitive processes supported by an extended set of brain regions. Our aim here was to shed light on one key component of future thinking—personal goal processing—and to determine its neural correlates during both directed and spontaneous forms of thoughts. To address this question, we performed separate ALE meta-analyses of neuroimaging studies of episodic future thinking, mind-wandering, and personal goal processing, and then investigated the commonalities and differences in brain activity between these three domains. The results showed that the three domains activated a common set of brain regions within the default network and, most notably, the medial prefrontal cortex. This finding suggests that the medial prefrontal cortex mediates the processing of personal goals during both episodic future thinking and mind-wandering. Differences in activation were also observed, and notably regions supporting cognitive control processes (the dorsolateral prefrontal cortex) were recruited to a lesser extent during mind-wandering than experimentally directed future thinking, suggesting that different kinds of self-generated thoughts may recruit varying levels of attentional control abilities. [less ▲]

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See detailUrban governance adaptation in an old industrial city: Liège (Belgium)
Breuer, Christophe ULg; Halleux, Jean-Marie ULg; Teller, Jacques ULg

in Francese, Dora (Ed.) Napoli Citta Metropolitana (in press)

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See detailWhere do hybrids come from? Entrepreneurial team heterogeneity as an avenue for the emergence of hybrid organizations
Dufays, Frédéric ULg; Huybrechts, Benjamin ULg

in International Small Business Journal (in press)

This conceptual paper aims to respond to the poorly addressed question of the emergence of hybrid organizations – i.e. organizations that embrace several institutional logics. It does so by developing a ... [more ▼]

This conceptual paper aims to respond to the poorly addressed question of the emergence of hybrid organizations – i.e. organizations that embrace several institutional logics. It does so by developing a model and a set of propositions focusing on the heterogeneity of the entrepreneurial team as a possible driver for hybridity throughout the entrepreneurial process and up to the emergence of a hybrid organization. As contributions to the literatures on (collective) entrepreneurship, imprinting and hybrid organizations, we advance several avenues and conditions under which the heterogeneity of the entrepreneurial team may imprint the entrepreneurial process and lead to the creation of hybrid organizations. Our propositions connect the individual, team and organizational levels and thus advance our understanding of how institutional logics can be combined across different levels of analysis and throughout the stages of an entrepreneurial process. [less ▲]

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See detailReinforcement Learning of Heuristic EV Fleet Charging in a Day-Ahead Electricity Market
Vandael, Stijn; Claessens, Bert; Ernst, Damien ULg et al

in IEEE Transactions on Smart Grid (in press)

This paper addresses the problem of defining a day-ahead consumption plan for charging a fleet of electric vehicles (EVs), and following this plan during operation. A challenge herein is the beforehand ... [more ▼]

This paper addresses the problem of defining a day-ahead consumption plan for charging a fleet of electric vehicles (EVs), and following this plan during operation. A challenge herein is the beforehand unknown charging flexibility of EVs, which depends on numerous details about each EV (e.g., plug-in times, power limitations, battery size, power curve, etc.). To cope with this challenge, EV charging is controlled during opertion by a heuristic scheme, and the resulting charging behavior of the EV fleet is learned by using batch mode reinforcement learning. Based on this learned behavior, a cost-effective day-ahead consumption plan can be defined. In simulation experiments, our approach is benchmarked against a multistage stochastic programming solution, which uses an exact model of each EVs charging flexibility. Results show that our approach is able to find a day-ahead consumption plan with comparable quality to the benchmark solution, without requiring an exact day-ahead model of each EVs charging flexibility. [less ▲]

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