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See detailL'utilisation du ratio sFlt-1/PlGF dans la prééclampsie: une analyse rétrospective monocentrique
Verbeurgt, Lievine ULg; CHANTRAINE, Frédéric ULg; DE MARCHIN, Jérôme et al

in Revue Médicale de Liège (in press)

La fms-like tyrosine kinase 1 soluble (sFlt-1) est un facteur anti-angiogénique libéré en quantité excessive dans la prééclampsie (PE) et impliqué dans la dysfonction endothéliale. Il est comparé au ... [more ▼]

La fms-like tyrosine kinase 1 soluble (sFlt-1) est un facteur anti-angiogénique libéré en quantité excessive dans la prééclampsie (PE) et impliqué dans la dysfonction endothéliale. Il est comparé au facteur de croissance placentaire pro-angiogénique (PlGF) qui diminue dans la PE. Le ratio sFlt-1/PlGF est présenté dans la littérature comme outil dans la prédiction de la prééclampsie. Un ratio < 38 confirme l’absence de prééclampsie à court-terme. Un ratio ≥ 85 dans la PE précoce (avant 34 semaines aménorrhée (SA)) et ≥ 110 dans le «late onset» (> 34 semaines d’aménorhhée) peut poser le diagnostic de prééclampsie. Dans cette étude rétrospective monocentrique, le ratio sFlt-1/PlGF a été dosé chez 183 patientes à risque dont 67 ont présenté une prééclampsie. Le ratio sFlt-1/PlGF médian pour toutes les patientes évaluées est 100,3. Le ratio médian pour les patientes ayant déclaré une prééclampsie (N=67) est 212,7 alors que celui des femmes sans prééclampsie (N=116) est de 35,4. En accord avec ces analyses, un ratio sFlt-1/PlGF ≥ 38 possède une sensibilité égale à 95,5% et une spécificité égale à 73,3%. Les valeurs prédictives positive (VPP) et négative (VPN) sont, respectivement, 67,4% et 96,6%. Ces résultats suggèrent que le ratio sFlt-1/PlGF peut être une aide dans le diagnostic de la prééclampsie [less ▲]

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See detailCarte géologique de la Wallonie à l'échelle 1:25.000. Stavelot-Malmedy n°50/5-6. Notice explicative.
Lamberty, Pauline ULg; Geukens, Fernand; Marion, Jean-Marc ULg

Book published by SPW/ Editions, Cartes - Révision et 3ème édition (in press)

New geological map of Wallonia that will be published at the scale of 1/25.000, based on a new field work and using previous scientific data produced, since the first edition published in 1899 (Gustave ... [more ▼]

New geological map of Wallonia that will be published at the scale of 1/25.000, based on a new field work and using previous scientific data produced, since the first edition published in 1899 (Gustave Dewalque) at the scale of 1/40,000 by the "Commission Géologique de Belgique" and the second one, published in 1963 (Fernand Geukens) at the scale of 1/25,000 by the Geological Survey of Belgium. [less ▲]

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See detailHarzé - La Gleize. Carte géologique de la Wallonie. Notice explicative
Lamberty, Pauline ULg; Marion, Jean-Marc ULg; Mottequin, Bernard et al

Book published by SPW/Editions (in press)

New geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced, since the first edition published in 1899 (Gustave Dewalque) at ... [more ▼]

New geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced, since the first edition published in 1899 (Gustave Dewalque) at the scale of 1/40.000 by the "Commission Géologique de Belgique" and the second one, published in 1959 (Asselberghs & Geukens) at the scale of 1/40.000 by the Geological Survey of Belgium. [less ▲]

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See detailLouveigné-Spa n°49/3-4. Carte géologique de la Wallonie à l'échelle du 1:25.000. Notice explicative
Marion, Jean-Marc ULg; Geukens, Fernand; Lamberty, Pauline ULg et al

Book published by SPW/Editions, Cartes - Révision et 3ème édition complète (in press)

Manuscript submitted for reviewing (2017/03); leaflet of the new geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced since ... [more ▼]

Manuscript submitted for reviewing (2017/03); leaflet of the new geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced since the previous editions, in 1898 (at the scale of 1/40.000, by Gustave Dewalque) and the second one, in 1958 (at the scale of 1/25.000 by Paul Fourmarier). [less ▲]

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See detailDual-Specificity Phosphatase Deletion Protects Female, but Not Male, Mice from Endotoxemia- and Polymicrobial-Induced Septic Shock
Vandereyken, Maud; Singh, Pratibha; Wathieu, Caroline ULg et al

in Journal of Immunology (in press)

Dual-specificity phosphatase 3 (DUSP3) is a small phosphatase with poorly known physiological functions and for which only a few substrates are known. Using DUSP3-deficient mice, we recently reported that ... [more ▼]

Dual-specificity phosphatase 3 (DUSP3) is a small phosphatase with poorly known physiological functions and for which only a few substrates are known. Using DUSP3-deficient mice, we recently reported that DUSP3 deficiency confers resistance to endotoxin- and polymicrobial-induced septic shock. We showed that this protection was macrophage dependent. In this study, we further investigated the role of DUSP3 in sepsis tolerance and showed that the resistance is sex dependent. Using adoptive-transfer experiments and ovariectomized mice, we highlighted the role of female sex hormones in the phenotype. Indeed, in ovariectomized female and male mice, the dominance of M2-like macrophages observed in DUSP32/2 female mice was reduced, suggesting a role for this cell subset in sepsis tolerance. At the molecular level, DUSP3 deletion was associated with estrogen dependent decreased phosphorylation of ERK1/2 and Akt in peritoneal macrophages stimulated ex vivo by LPS. Our results demonstrate that estrogens may modulate M2-like responses during endotoxemia in a DUSP3-dependent manner. [less ▲]

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See detailThe impact of architectural representations on conveying design intent.
Cunin, Maxime; Yang, Maria C.; Elsen, Catherine ULg

E-print/Working paper (in press)

Architects express themselves graphically in order to communicate ideas both to clients and to themselves. In practice, they rely on a variety of representations such as free-hand drawings, 3D computer ... [more ▼]

Architects express themselves graphically in order to communicate ideas both to clients and to themselves. In practice, they rely on a variety of representations such as free-hand drawings, 3D computer rendered images, and photomontages to convey their design intent. Research to date has demonstrated differences and commonalities in the ways in which expert designers and laymen perceive visual understanding. It is still unclear how architects themselves use different types of representations to express different intentions, and how accurately their expected audience perceives those intentions. The purpose of this research is to investigate how laymen interpret the initial design intent of an architect’s design, and what role different forms of representations play in this process of understanding a design. This paper describes a five-step process for developing a survey that was used to gather data from 686 laymen respondents. It was found that certain types of simpler representations presented in specific contexts are unexpectedly found to be a more efficient way to faithfully transmit an architectural intent. [less ▲]

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See detailCarte géologique de la Wallonie à l'échelle de 1/25 000. Seraing-Chênée n°42/5-6
Marion, Jean-Marc ULg; Mottequin, Bernard

Cartographic material (in press)

New version of the geological map of Belgium, sheet Seraing-Chênée n°134, previously published at the scale of 1/40000 by H. Forir and M. Mourlon (1897)

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See detailConfesseur du Prince : un profil singulier ? L’exemple de la cour espagnole de Bruxelles au XVIIe siècle.
Pirlet, Pierre-François ULg

in Les clergés de cour en Europe (fin XVe siècle - XVIIIe siècle). Service religieux et service politique dans les systèmes curiaux - Actes du colloque[Titre à préciser] (in press)

Au cœur de l'espace de la cour, le confesseur du Prince présente un profil singulier. La relation qu'il entretient avec son pénitent est unique : tenu à l'obéissance envers le souverain ou son ... [more ▼]

Au cœur de l'espace de la cour, le confesseur du Prince présente un profil singulier. La relation qu'il entretient avec son pénitent est unique : tenu à l'obéissance envers le souverain ou son représentant pour les aspects temporels, ce religieux a la faculté unique d'examiner, de conseiller et de juger la spiritualité du premier personnage de l'État. Attaché à la personne du Prince, les relations de cet ecclésiastique avec les autres courtisans ne peuvent être appréhendées au moyen d'une grille de lecture hiérarchisant les rapports sociaux : échappant à l'organisation laïque – mais pas protocolaire – de la cour et ne dépendant pas directement de la Chapelle royale, le confesseur bénéficie d'une autonomie relative. En outre, son pouvoir politique, en partie officiel grâce aux dignités et charges dont ce religieux est pourvu, est avant tout perçu comme une magistrature d'influence à la portée difficilement mesurable. Enfin, les obligations matérielles liées à l'appartenance de ce prélat à un ordre religieux achèvent de distinguer cet ecclésiastique des autres serviteurs princiers. Cette communication visera à distinguer les particularités de la charge de confesseur princier au sein de la société de cour. L'étude portera particulièrement sur la cour de Bruxelles durant la première moitié du xviie siècle. [less ▲]

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See detailPulse-Based Control Using Koopman Operator Under Parametric Uncertainty
Sootla, Aivar; Ernst, Damien ULg

in IEEE Transactions on Automatic Control (in press)

In applications, such as biomedicine and systems/synthetic biology, technical limitations in actuation complicate implementation of time-varying control signals. In order to alleviate some of these ... [more ▼]

In applications, such as biomedicine and systems/synthetic biology, technical limitations in actuation complicate implementation of time-varying control signals. In order to alleviate some of these limitations, it may be desirable to derive simple control policies, such as step functions with fixed magnitude and length (or temporal pulses). In this technical note, we further develop a recently proposed pulse-based solution to the convergence problem, i.e., minimizing the convergence time to the target exponentially stable equilibrium, for monotone systems. In particular, we extend this solution to monotone systems with parametric uncertainty. Our solutions also provide worst-case estimates on convergence times. Furthermore, we indicate how our tools can be used for a class of non-monotone systems, and more importantly how these tools can be extended to other control problems. We illustrate our approach on switching under parametric uncertainty and regulation around a saddle point problems in a genetic toggle switch system. [less ▲]

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See detailCombined Local and Centralized Voltage Control in Active Distribution Networks
Soleimani Bidgoli, Hamid ULg; Van Cutsem, Thierry ULg

in IEEE Transactions on Power Systems (in press)

A two-level real-time voltage control scheme is proposed to keep voltages within specified limits in distribution grids using Distributed Generation Units (DGUs). It combines a local and a centralized ... [more ▼]

A two-level real-time voltage control scheme is proposed to keep voltages within specified limits in distribution grids using Distributed Generation Units (DGUs). It combines a local and a centralized control of their reactive powers. The local control provides fast response after a disturbance, reducing its impact and enhancing voltage quality. The centralized control uses measurements collected throughout the network to bring the voltages inside tighter limits and balance the various DGU contributions. To this purpose, it adjusts in a coordinated way their reactive power set-points, taking into account the local controls. This discrete control solves at each time step a multi-time-step constrained optimization inspired of Model Predictive Control. The method effectiveness is demonstrated on a 75-bus test system hosting 22 DGUs. [less ▲]

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See detailA biased random key genetic algorithm applied to the electric distribution network reconfiguration problem
de Faria Jr., Haroldo; Resende, Mauricio; Ernst, Damien ULg

in Journal of Heuristics (in press)

This work presents a biased random-key genetic algorithm (BRKGA) to solve the electric distribution network reconfiguration problem (DNR). The DNR is one of the most studied combinatorial optimization ... [more ▼]

This work presents a biased random-key genetic algorithm (BRKGA) to solve the electric distribution network reconfiguration problem (DNR). The DNR is one of the most studied combinatorial optimization problems in power system analysis. Given a set of switches of an electric network that can be opened or closed, the objective is to select the best configuration of the switches to optimize a given network objective while at the same time satisfying a set of operational constraints. The good performance of BRKGAs on many combinatorial optimization problems and the fact that it has never been applied to solve DNR problems are the main motivation for this research. A BRKGA is a variant of random-key genetic algorithms, where one of the parents used for mating is biased to be of higher fitness than the other parent. Solutions are encoded by using random keys, which are represented as vectors of real numbers in the interval (0,1), thus enabling an indirect search of the solution inside a proprietary search space. The genetic operators do not need to be modified to generate only feasible solutions, which is an exclusive task of the decoder of the problem. Tests were performed on standard distribution systems used in DNR studies found in the technical literature and the performance and robustness of the BRKGA were compared with other GA implementations. [less ▲]

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See detailStochastic Inventory Routing for Perishable Products
Crama, Yves ULg; Rezaei Sadrabadi, Mahmood ULg; Savelsbergh, Martin et al

in Transportation Science (in press)

Different solution methods are developed to solve an inventory routing problem for a perishable product with stochastic demands. The solution methods are compared empirically in terms of average profit ... [more ▼]

Different solution methods are developed to solve an inventory routing problem for a perishable product with stochastic demands. The solution methods are compared empirically in terms of average profit, service level, and actual freshness. The benefits of explicitly considering demand uncertainty are quantified. The computational study highlights that in certain situations a simple ordering policy can already reach a very good performance, but that statistically and economically significant improvements are achieved when using more advanced solution methods. Managerial insights concerning the impact of shelf life and store capacity on profit are also obtained. [less ▲]

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See detailMicrobiological zoonotic emerging risks, transmitted between livestock animals and humans (2007-2015)
Filippitzi, ME; Goumperis, T; Robinson, T et al

in Transboundary and emerging diseases (in press)

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See detailArrêt(s) sur image(s) : usages et pratiques du photogramme
Thonon, Jonathan ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (in press)

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See detailQuatre configurations pour créer une dynamique interactive entre formation et recherche Expériences dans le domaine de la formation des professionnels de la santé
Faulx, Daniel ULg; Burlet, Géraldine ULg; Bernard, Nicolas ULg et al

in Recherches Qualitatives (in press)

Dans cette contribution, nous nous penchons sur la possibilité de créer une dynamique interactive entre intervention sur le terrain et recherche scientifique dans le domaine de la formation. Les terrains ... [more ▼]

Dans cette contribution, nous nous penchons sur la possibilité de créer une dynamique interactive entre intervention sur le terrain et recherche scientifique dans le domaine de la formation. Les terrains d’application se situent tous ici dans le domaine de la santé. Nous présentons quatre configurations d’une telle complémentarité. Chacune d’entre elles représente une articulation différente entre le but de développement des participants et celui de production de savoirs scientifiques. Dans le premier cas, une démarche de recherche est entreprise en amont de la conception d’une formation. La deuxième configuration illustre une recherche scientifique appliquée à un dispositif d’intervention existant et qui vient en retour en modifier la logique. Pour la troisième, il s’agit d’une articulation continue entre recherche et formation s’alimentant mutuellement dans une logique de recherche-action. Enfin, la quatrième partie se penche sur trois dispositifs pédagogiques dont la caractéristique est de combiner des intentions formatives avec des préoccupations de recherche [less ▲]

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See detailRNA-seq-based genome reannotation of dermatophyte Arthroderma benhamiae, characterization of its secretome and whole gene expression profile during infection
Tran, T; De Coi, N; Feuermann, M et al

in Genome Announcements (in press)

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See detailLa place de l'arbre dans les systèmes agricoles par les populations locales
Hick, Aurélie ULg; Hallin, Maud; Tshibungu, Alain et al

in Mahy, Grégory; Colinet, Gilles; Bogaert, Jan (Eds.) Anthropisation au Katanga (in press)

Dans un contexte de déforestation massive dans les zones rurales adjacentes aux grandes métropoles de la République Démocratique du Congo (RDC), zones d’approvisionnement en bois-énergie, l’identification ... [more ▼]

Dans un contexte de déforestation massive dans les zones rurales adjacentes aux grandes métropoles de la République Démocratique du Congo (RDC), zones d’approvisionnement en bois-énergie, l’identification de la place et du rôle que prend l’arbre dans les villages constituent un préalable à tous plan de restauration forestière. Ce chapitre porte sur les connaissances taxonomiques, les usages et la distribution des espèces arborées indigènes au sein de quatre villages en zone rurale adjacente à la ville de Lubumbashi, chef-lieu de la province du Katanga en RDC. Un total de 49 espèces indigènes de la forêt claire a été identifié par les 51 familles interrogées. Les utilisations sont classées en 6 catégories. Neuf espèces sont connues par plus de 50% des familles et correspondent aux espèces les plus utilisées pour l’alimentation via la consommation de leurs fruits et pour la confection d’outils. Les espèces citées par les personnes interrogées ne sont pas présentes dans le système agricole. La densité d’arbre à l’hectare au sein des champs est faible. Les espèces présentes sont des espèces résistantes aux facteurs de dégradation. Cette étude a montré que la connaissance taxonomique est limitée aux espèces les plus utilisées. Il n’y a pas de gestion intégrée de l’arbre au sein du système agricole dans la zone rurale adjacente à la ville de Lubumbashi. [less ▲]

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See detailThe effect of spaceflight and microgravity on the human brain
Van Ombergen, Angelique; Demertzi, Athina ULg; Tomilovskaya et al

in Journal of Neurology (in press)

Microgravity, confinement, isolation, and immobilization are just some of the features astronauts have to cope with during space missions. Consequently, long-duration space travel can have detrimental ... [more ▼]

Microgravity, confinement, isolation, and immobilization are just some of the features astronauts have to cope with during space missions. Consequently, long-duration space travel can have detrimental effects on human physiology. Although research has focused on the cardiovascular and musculoskeletal system in particular, the exact impact of spaceflight on the human central nervous system remains to be determined. Previous studies have reported psychological problems, cephalic fluid shifts, neurovestibular problems, and cognitive alterations, but there is paucity in the knowledge of the underlying neural substrates. Previous space analogue studies and preliminary spaceflight studies have shown an involvement of the cerebellum, cortical sensorimotor, and somatosensory areas and the vestibular pathways. Extending this knowledge is crucial, especially in view of long-duration interplanetary missions (e.g., Mars missions) and space tourism. In addition, the acquired insight could be relevant for vestibular patients, patients with neurodegenerative disorders, as well as the elderly population, coping with multisensory deficit syndromes, immobilization, and inactivity. [less ▲]

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See detailDynamic Equivalent of a Distribution Grid Hosting Dispersed Photovoltaic Units
Chaspierre, Gilles ULg; Panciatici, Patrick; Van Cutsem, Thierry ULg

in IREP’2017 Symposium: X Bulk Power Systems Dynamics and Control Symposium (in press)

This paper deals with the derivation of a simplified model of a distribution network hosting dispersed photovoltaic units. The model is aimed at short-term dynamic simulations of a transmission grid in ... [more ▼]

This paper deals with the derivation of a simplified model of a distribution network hosting dispersed photovoltaic units. The model is aimed at short-term dynamic simulations of a transmission grid in response to large disturbances. In a first step, a generic dynamic model of a photovoltaic unit is proposed, focusing on its interactions with the grid, in particular the controls triggered by voltage disturbances. The model takes into account various present and near-future grid codes. In a second step, a dynamic equivalent is derived accounting for the distribution network, the dispersed photovoltaic units, as well as static and dynamic (motor) loads. This equivalent is of the “grey-box” type and its parameters are tuned in the least-square sense to match the dynamic response of the original, unreduced system. Simulation results are reported on a detailed 913-bus distribution system subject to faults at transmission level. [less ▲]

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See detailLes troubles du sommeil chez l'enfant autiste, quel rôle pour le pédopsychiatre?
Abate Ekollo, Joëlle; Malchair, Alain ULg

in Acta Psychiatrica Belgica (in press)

Les troubles du sommeil sont fréquents chez l’enfant et leurs origines sont diverses. Ces troubles ont leur ancrage dans le développement neurophysiologique et psychoaffectif de l’enfant. Les enfants ... [more ▼]

Les troubles du sommeil sont fréquents chez l’enfant et leurs origines sont diverses. Ces troubles ont leur ancrage dans le développement neurophysiologique et psychoaffectif de l’enfant. Les enfants souffrant de troubles du spectre autistique présentent un déficit de sommeil, qui peut durer jusqu’à l’adolescence. Les troubles du spectre autistique comportent des comorbidités multiples, dont des altérations du sommeil. Ils sont importants à caractériser dans cette population, car ils peuvent avoir un impact négatif sur les comportements diurnes. Par ailleurs, ils entrainent souvent des difficultés au sein de la famille. La prise en charge doit avant tout prendre en compte le contexte environnemental afin d’améliorer les habitudes et l’hygiène du sommeil. Des questionnaires ainsi que des agendas de sommeil ont été remplis par des parents afin de démontrer l’importance d’une évaluation et d’une prise en compte des troubles du sommeil chez les enfants souffrant d’autisme en consultation pédopsychiatrique. [less ▲]

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