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See detailCarte géologique de Wallonie. Huy-Nandrin n°48/3-4
Mottequin, Bernard; Marion, Jean-Marc ULiege

Cartographic material (in press)

New geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced since the first edition by Gustave Dewalque & colleagues (1898 ... [more ▼]

New geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced since the first edition by Gustave Dewalque & colleagues (1898) published at the scale of 1/40.000 [less ▲]

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See detailPsychological interventions influence patients' attitudes and beliefs about their chronic pain.
VANHAUDENHUYSE, Audrey ULiege; Gillet, Aline; MALAISE, Nicole ULiege et al

in Journal of Traditional and Complementary Medicine (in press)

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See detailCytotoxic T-lymphocyte-associated protein 4-Ig effectively controls immune activation and inflammatory disease in a novel murine model of leaky severe combined immunodeficiency
Humblet-Baron, Stephanie; Schönefeldt, Susan; Garcia-Perez, Josselyn E et al

in Journal of Allergy and Clinical Immunology (The) (in press)

Background: Severe combined immunodeficiency (SCID) can be caused by loss-of-function mutations in genes involved in the DNA recombination machinery, such as RAG1, RAG2 or DCLRE1C. Defective DNA ... [more ▼]

Background: Severe combined immunodeficiency (SCID) can be caused by loss-of-function mutations in genes involved in the DNA recombination machinery, such as RAG1, RAG2 or DCLRE1C. Defective DNA recombination causes a developmental block in T cells and B cells, resulting in high susceptibility to infections. Hypomorphic mutations in the same genes can also give a partial loss of T cells, in a spectrum including leaky SCID (LS) and Omenn syndrome (OS). These patients not only develop life-threatening infections due to immunodeficiency, but also develop inflammatory/autoimmune conditions due to the presence of autoreactive T cells. Objective: We sought to develop a preclinical model that fully recapitulates the symptoms of LS/OS patients including a model for testing therapeutic intervention. Methods: We generated a novel mutant mouse (Dclre1c leaky) that develops a LS phenotype. Mice were monitored for diseases and immune phenotype and immune function were evaluated using flow cytometry, ELISA and histology. Results: Dclre1c leaky mice present with a complete blockade of B cell differentiation, with a leaky block in T cell differentiation resulting in an oligoclonal TCR repertoire and enhanced cytokine secretion. Dclre1c leaky mice also developed inflammatory symptoms including wasting, dermatitis, colitis, hypereosinophilia and high IgE levels. Development of a preclinical murine model for LS allowed the testing of potential treatment, with administration of CTLA4-Ig reducing disease symptoms and immunological disturbance, resulting in increased survival. Conclusion: These data suggest that CTLA4-Ig should be evaluated as a potential treatment of inflammatory symptoms in LS and OS patients. [less ▲]

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See detailDe l'état littéraire à une théorie de l'Etat. Une lecture cursive de La Musique et les Lettres
Durand, Pascal ULiege

in Millan, Gordon (Ed.) Mallarmé à Tournon et au-delà (in press)

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See detailThe unexpected discovery of Brucella abortus Buck 19 vaccine in goats from Ecuador underlines the importance of biosecurity measures
Ron-Roman, J; Berkvens, D; Barzallo-Rivadeneira, D et al

in Tropical Animal Health and Production (in press)

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See detailMulti-temporal monitoring of a regional riparian buffer network (>12,000 km) with LiDAR and photogrammetric point clouds
Michez, Adrien ULiege; Piégay, Hervé; Lejeune, Philippe ULiege et al

in Journal of Environmental Management (in press)

Riparian buffers are of major concern for land and water resource managers despite their relatively low spatial coverage. In Europe, this concern has been acknowledged by different environmental ... [more ▼]

Riparian buffers are of major concern for land and water resource managers despite their relatively low spatial coverage. In Europe, this concern has been acknowledged by different environmental directives which recommend multi-scale monitoring (from local to regional scales). Remote sensing methods could be a cost-effective alternative to field-based monitoring, to build replicable “wall-to-wall” monitoring strategies of large river networks and associated riparian buffers. The main goal of our study is to extract and analyze various parameters of the riparian buffers of up to 12,000 km of river in southern Belgium (Wallonia) from three-dimensional (3D) point clouds based on LiDAR and photogrammetric surveys to i) map riparian buffers parameters on different scales, ii) interpret the regional patterns of the riparian buffers and iii) propose new riparian buffer management indicators. We propose different strategies to synthesize and visualize relevant information at different spatial scales ranging from local (<10 km) to regional scale (>12,000 km). Our results showed that the selected parameters had a clear regional pattern. The reaches of Ardenne ecoregion have channels with the highest flow widths and shallowest depths. In contrast, the reaches of the Loam ecoregion have the narrowest and deepest flow channels. Regional variability in channel width and depth is used to locate management units potentially affected by human impact. Riparian forest of the Loam ecoregion is characterized by the lowest longitudinal continuity and mean tree height, underlining significant human disturbance. As the availability of 3D point clouds at the regional scale is constantly growing, our study proposes reproducible methods which can be integrated into regional monitoring by land managers. With LiDAR still being relatively expensive to acquire, the use of photogrammetric point clouds combined with LiDAR data is a cost-effective means to update the characterization of the riparian forest conditions. [less ▲]

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See detailOutbreak investigations and molecular characterization of foot-and-mouth disease viruses circulating in southwest Niger
Kouato; Fana, EM; King, DP et al

in Transboundary and Emerging Diseases (in press)

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See detailThe Antitrust and Intellectual Property Intersection in European Union Law
Petit, Nicolas ULiege

in Blair, Roger; Sokol, Danie (Eds.) Roger D. Blair & D. Daniel Sokol (in press)

In European legal scholarship, many articles discuss the equilibrium reached in the case-law of the Court of Justice of the European Union (“CJEU”) when the EU antitrust prohibitions apply to, and ... [more ▼]

In European legal scholarship, many articles discuss the equilibrium reached in the case-law of the Court of Justice of the European Union (“CJEU”) when the EU antitrust prohibitions apply to, and restrain, the free and ordinary use of intellectual property rights (“IPRs”). We call this the antitrust-IP intersection. The most interesting feature of this literature is perhaps the common assumption that a unifying substantive perspective, vision or theory on IPR underpins the intersection point reached by the antitrust case-law. Whilst the theory of “absolutism” can be quickly disposed of, several other theories like inherency, exceptionalism or complementarity have been described as the lynchpin of the antitrust-IP intersection. Our paper offers a different reading of the case-law. It submits that the antitrust-IP intersection does not rest on any unitary theory which, in turn, bespeaks the Court’s vision of the social function of IPRs. Instead, the main feature of the CJEU case-law is that a specific methodology is applied to antitrust cases with IPR ramifications. The CJEU deals with most of such cases under a rule-based approach, instead of a standard-based approach. By rule-based approach, we refer to the ex ante setting of structured tests of liability, by opposition to ex post case-by-case resolution on grounds of a pre-determined, general standard (e.g., reasonableness, competition on the merits, efficiency, fairness, equity, etc.). As will be seen below, this approach has many virtues, not least in terms of legal certainty. But it also has a major qualification. Whilst the Court has consistently formulated rules of liability and justifiability at the antitrust and IP intersection, it has at the same time often embedded abstract standards within those rules. The implications of this mixed approach are unclear. [less ▲]

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See detailInclusion of Down Syndrome in Architectural Design: Towards a Methodology
Schelings, Clémentine ULiege; Elsen, Catherine ULiege

in Proceedings of the second international conference on Universal Accessibility in the Internet of Things and Smart Environments (in press)

This paper develops an in-situ methodology to help architects insure better inclusion of people with Down syndrome all along preliminary phases of the architectural design process, and eventually to the ... [more ▼]

This paper develops an in-situ methodology to help architects insure better inclusion of people with Down syndrome all along preliminary phases of the architectural design process, and eventually to the designed space. This methodology first offers architects some design keys in regard of how people with Down syndrome interact with two types of spaces: their personal dwellings and some completely unknown spaces. The methodology then unfolds towards more pro-active inclusion of the participants thanks to playful expression of their feelings and perceptions. This paper discusses how this methodology relates to inclusive and universal design principles as well as prevalent models of disability in architecture. [less ▲]

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See detailFrom seascape level to functional ecology: A case study over P. oceanica seagrass meadows in Calvi, Corsica
Lapeyra Martin, Jon ULiege; Abadie, Arnaud; Richir, Jonathan ULiege et al

in Actes du colloque Carhamb'ar 2017 (in press)

see long abstract

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See detailSerogroups and genotypes of Leptospira 1 spp. strains from bovine aborted fetuses
Delooz, L; Czaplicki, G; Grégoire, F et al

in Transboundary and Emerging Diseases (in press)

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See detailVoice use among music theory teachers: A voice dosimetry and self-assessment study
Schiller, Isabel ULiege; Morsomme, Dominique ULiege; Remacle, Angélique ULiege

in Journal of Voice (in press)

Objectives: (1) To investigate music theory teachers’ professional and extra-professional vocal loading and background noise exposure, (2) to determine the correlation between vocal loading and background ... [more ▼]

Objectives: (1) To investigate music theory teachers’ professional and extra-professional vocal loading and background noise exposure, (2) to determine the correlation between vocal loading and background noise, and (3) to determine the correlation between vocal loading and self-evaluation data. Methods: Using voice dosimetry, 13 music theory teachers were monitored for one workweek. Parameters analysed were voice SPL, F0, phonation time, vocal loading index (VLI) and noise SPL. Spearman’s correlation was used to correlate vocal loading parameters (voice SPL, F0 and phonation time) and noise SPL. Each day, subjects self-assessed their voice using visual analogue scales. VLI and self-evaluation data were correlated using Spearman’s correlation. Results: Vocal loading parameters and noise SPL were significantly higher in the professional than in the extra-professional environment. Voice SPL, phonation time and females’ F0 correlated positively with noise SPL. VLI correlated with self-assessed voice quality, vocal fatigue and amount of singing and speaking voice produced. Conclusions: Teaching music theory is a profession with high vocal demands. More background noise is associated with increased vocal loading and may indirectly increase the risk for voice disorders. Correlations between VLI and self-assessments suggest that these teachers are well-aware of their vocal demands and feel their effect on voice quality and vocal fatigue. Visual analogue scales seem to represent a useful tool for subjective vocal loading assessment and associated symptoms in these professional voice users. [less ▲]

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See detailCarte géologique de Wallonie. Louveigné-Spa n°49/3-4
Marion, Jean-Marc ULiege; Geukens, Fernand; Lamberty, Pauline ULiege et al

Cartographic material (in press)

New geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced since the previous editions, in 1898 (at the scale of 1/40.000, by ... [more ▼]

New geological map of Wallonia published at the scale of 1/25.000, based on a new field work and using previous scientific data produced since the previous editions, in 1898 (at the scale of 1/40.000, by Gustave Dewalque) and the second one, in 1958 (at the scale of 1/25.000 by Paul Fourmarier). [less ▲]

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See detailMind-wandering and self-referential thought
D'Argembeau, Arnaud ULiege

in The Oxford Handbook of Spontaneous Thought (in press)

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See detailPotential demal exposure of florists to fungicide residues on flowers and risk assessment
Toumi; Joly, L.; Vleminckx, C. et al

in Communications in Agricultural and Applied Biological Sciences (in press)

Flowers are susceptible to many pests and diseases. Therefore, they can be sprayed several times during their growth considering that no MRL are set for flow-ers. High levels of pesticide residues ... [more ▼]

Flowers are susceptible to many pests and diseases. Therefore, they can be sprayed several times during their growth considering that no MRL are set for flow-ers. High levels of pesticide residues potentially expose daily the florists who han-dle cut flowers and possibly could endanger their health. A study was carried out to evaluate the risk for florists exposed to fungicide residues during normal profes-sional tasks. Cotton gloves were distributed to 20 florists (two pairs to each florist) and worn during two consecutive half days during normal professional tasks (from min 2 hours to max 3 hours/day) to measure their potential dermal exposure (PDE). Samples were analyzed with a multi-residue (QuEChERS) method validated by a laboratory accredited for pesticide residues and with a combination of gas and liquid chromatography tandem mass spectrometry. It appears from the results that a total of 54 fungicides with different toxicity classes were detected on cotton gloves. An average of 15.53 mg/kg fungicide residues per glove sample was meas-ured. Six of 54 are suspected of causing cancer after prolonged or repeated expo-sure. Boscalid was both the active substance for which the highest maximum and average concentrations (26.21 and 3.47 mg/kg, respectively). Famoxadone had the most critical PDE (156% AOEL for the maximum concentration). As a consequence, this study leads to conclude that Belgian florists, who worked for several years and handled a large number of flowers contaminated by high concentrations of pesti-cide residues, are exposed daily with a potential effect on their health. This sug-gests that safety standards should be set for residue levels on cut flowers. [less ▲]

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See detailRisk assessment for small farmers exposed to plant protection products in the Niger River valley
Massalatchi Illyassou, Karimoun; Adamou, R.; Schiffers, Bruno ULiege

in Communications in Agricultural and Applied Biological Sciences (in press)

Plant protection products play a very important role in agriculture. However, their misuse can have serious negative impacts both on human health and environment. A study was carried out to identify the ... [more ▼]

Plant protection products play a very important role in agriculture. However, their misuse can have serious negative impacts both on human health and environment. A study was carried out to identify the plant protection products used in the Niger River valley and to observe the local pesticide management practices. Ten active substances were identified as the most used chemicals by farmers. Their toxicological properties were characterized and their respective Potential Dermal Exposures (PDE) was evaluated in order to assess the risk level for the local small growers. The UK Predictive Operator Exposure Model was used to quantify the PDE during mixing/loading and application according to the local practices. The survey shows that the most common active substances are organophosphate or pyrethroids insecticides. In addition, some other prohibited and counterfeit pesticides cocktails are also used. All active substances used in Niger River valley are highly toxic. When sprayed without personal protective equipment (PPE) they could induce significant harmful impacts on the human health after exposure. The predictive exposure levels vary from 0.0013 mg/kg bw/day to 0.4125 mg/kg bw/day, several times higher the Acceptable Operator Exposure Level (AOEL) for all actives substances. The survey also revealed that 76% of operators do not use any PPE during mixing/loading or spraying. Other bad practices observed in study area can increase the exposure of operators. Moreover, local consumers could also be exposed through intake of pesticide residues on harvested products. [less ▲]

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See detailStudy of the chemical composition of essential oils and floral waters of Cymbopogon citratus (DC.) Stapf (Poaceae) from Senegal
Diop, Serigne Mbacké; Guèye, Momar Talla; Ndiaye, Ibrahima et al

in International Journal of Biological and Chemical Sciences (in press)

This work aimed to study the chemical composition of essential oils and floral waters of Cymbopogon citratus (DC.) Stapf (Poaceae) from Senegal. The plants were collected in two different localities ... [more ▼]

This work aimed to study the chemical composition of essential oils and floral waters of Cymbopogon citratus (DC.) Stapf (Poaceae) from Senegal. The plants were collected in two different localities, Dakar and Kaolack. The extracts were obtained by steam distillation from both fresh and dried plants and analyses carried out by GC/FID and GC/MS. Oils from Dakar were dominated by geranial which represented 46.0-43.9%, neral 31.8-31.0%, myrcene 10.8-11.7% and geraniol 2.7-4.2% in the fresh and dried plants, respectively. Their floral waters contained mainly 44.6-41.4% geranial, 39.7-35.6% neral and 8.8-13.2% geraniol. The oils from Kaolack were characterized by geranial which constituted 49.5-44.5%, neral 33.3-31.2%, myrcene 7.2-9.6% and geraniol 4.3-6.1% in the fresh and dried plants, respectively. In their floral waters, it is identified 42.8-33.6% geranial, 38.4-27.6% neral and 12.5-24.5% geraniol. This original study revealed that both oils and floral waters of C. citratus from Senegal are characterized by geranial and neral whose repellent properties against mosquitoes are known. [less ▲]

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See detailAutomated multimodal volume registration based on supervised 3D anatomical landmark detection
Vandaele, Rémy ULiege; LALLEMAND, François ULiege; MARTINIVE, Philippe ULiege et al

in SCITEPRESS Digital Library (in press)

We propose a new method for automatic 3D multimodal registration based on anatomical landmark detection. Landmark detectors are learned independantly in the two imaging modalities using Extremely ... [more ▼]

We propose a new method for automatic 3D multimodal registration based on anatomical landmark detection. Landmark detectors are learned independantly in the two imaging modalities using Extremely Randomized Trees and multi-resolution voxel windows. A least-squares fitting algorithm is then used for rigid registration based on the landmark positions as predicted by these detectors in the two imaging modalities. Experiments are carried out with this method on a dataset of pelvis CT and CBCT scans related to 45 patients. On this dataset, our fully automatic approach yields results very competitive with respect to a manually assisted state-of-the-art rigid registration algorithm. [less ▲]

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See detailSTARECAPMED, des indices pour La Méditerranée
Leduc, Michèle; Abadie, Arnaud; Donnay, Annick et al

in Actes du colloque Carhamb'ar 2017 (in press)

Le projet STARECAPMED (STAtion of Reference and rEsearch on Change of local and global Anthropogenic Pressures on Mediterranean Ecosystems Drifts) a pour objectif (i) d’améliorer la compréhension du ... [more ▼]

Le projet STARECAPMED (STAtion of Reference and rEsearch on Change of local and global Anthropogenic Pressures on Mediterranean Ecosystems Drifts) a pour objectif (i) d’améliorer la compréhension du fonctionnement des différents écosystèmes marins côtiers présents en Méditerranée et (ii) de décrire l’influence des activités humaines sur les processus qui gouvernent ce fonctionnement. La baie de Calvi, par sa situation exceptionnelle, est un site de référence de la Directive Européenne Cadre sur l’Eau (DCE), du monitoring de l’eutrophisation et de la contamination par les éléments traces. La Station de recherches océanographiques STARESO, implantée dans la baie depuis près de 50 ans, possède un accès unique à la mer et de nombreuses facilités logistiques. Elle a développé au fil du temps une expertise scientifique reposant notamment sur l’acquisition de longues séries temporelles de données environnementales. Ensemble, Baie et Station s’intègrent en un site atelier dédié à l’évaluation de l’état de santé des écosystèmes marins côtiers de Méditerranée Nord-Occidentale. En particulier, différents indices et indicateurs y sont développés en collaboration avec de nombreux laboratoires partenaires. Ainsi, nous avons développé, d’une part, une version non destructive de l’indice PREI (Posidonia Rapid Easy Index) d’évaluation de la qualité des eaux côtières reposant sur le suivi des herbiers à Posidonia oceanica, et d’autre part, deux indices d’évaluation de l’impact des ancrages, puis testé   l’indice EBQI (Ecosystem Based Quality Index), une approche sur la diversité écologique. Les indices TEPI (Trace Element Pollution Index) et TESVI (Trace Element Spatial Variation Index) permettent d’évaluer la contamination par les éléments traces. Le BeMSI (BEnthic Methodology Simplification) est un nouvel indicateur de la qualité du milieu défini à partir de la composition des peuplements macrobenthiques des substrats meubles et plus généralement, l’indice LIMA traduit l’attrait paysager et la richesse patrimoniale du benthos méditerranéen entre 0 et –40 m. Quant à l’indice ICAR (Indice paysager CAulerpa Racemosa), il permet d’évaluer les niveaux de colonisation par l’algue invasive Caulerpa cylindracea. Enfin, une approche innovante reposant sur l’enregistrement des sons permet d’évaluer la qualité du milieu à partir d’un paysage acoustique sous-marin. En conclusion, le développement et l’application combinée de ces différents indices et indicateurs développés dans le cadre du programme pluridisciplinaire STARECAPMED fournissent une estimation globale des états du milieu côtier méditerranéen à différents niveaux d’organisation, depuis l’espèce jusqu’à l’écosystème. De plus, leur mise en œuvre dans ce même site atelier privilégié permet de les confronter, de les ajuster et de les intercalibrer pour à terme les proposer aux gestionnaires du milieu côtier. [less ▲]

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