Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism.
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in Journal of the American College of Cardiology (2012), 60(8), 722-9
OBJECTIVES: The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic components. BACKGROUND ... [more ▼]
OBJECTIVES: The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic components. BACKGROUND: It is unclear whether the LPA variants rs10455872 and rs3798220, which correlate with lipoprotein(a) levels and coronary artery disease (CAD), confer susceptibility predominantly via atherosclerosis or thrombosis. METHODS: The 2 LPA variants were combined and examined as LPA scores for the association with ischemic stroke (and TOAST [Trial of Org 10172 in Acute Stroke Treatment] subtypes) (effective sample size [n(e)] = 9,396); peripheral arterial disease (n(e) = 5,215); abdominal aortic aneurysm (n(e) = 4,572); venous thromboembolism (n(e) = 4,607); intracranial aneurysm (n(e) = 1,328); CAD (n(e) = 12,716), carotid intima-media thickness (n = 3,714), and angiographic CAD severity (n = 5,588). RESULTS: LPA score was associated with ischemic stroke subtype large artery atherosclerosis (odds ratio [OR]: 1.27; p = 6.7 x 10(-4)), peripheral artery disease (OR: 1.47; p = 2.9 x 10(-14)), and abdominal aortic aneurysm (OR: 1.23; p = 6.0 x 10(-5)), but not with the ischemic stroke subtypes cardioembolism (OR: 1.03; p = 0.69) or small vessel disease (OR: 1.06; p = 0.52). Although the LPA variants were not associated with carotid intima-media thickness, they were associated with the number of obstructed coronary vessels (p = 4.8 x 10(-12)). Furthermore, CAD cases carrying LPA risk variants had increased susceptibility to atherosclerotic manifestations outside of the coronary tree (OR: 1.26; p = 0.0010) and had earlier onset of CAD (-1.58 years/allele; p = 8.2 x 10(-8)) than CAD cases not carrying the risk variants. There was no association of LPA score with venous thromboembolism (OR: 0.97; p = 0.63) or intracranial aneurysm (OR: 0.85; p = 0.15). CONCLUSIONS: LPA sequence variants were associated with atherosclerotic burden, but not with primarily thrombotic phenotypes. [less ▲]Detailed reference viewed: 3 (0 ULg)
L’adaptation au changement climatique en région wallonne
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Climate change is now globally accepted. The 4th IPCC report, published in 2007, clearly indicates that this phenomenon is mostly the result of human activity. All parts of the globe are potentially at ... [more ▼]
Climate change is now globally accepted. The 4th IPCC report, published in 2007, clearly indicates that this phenomenon is mostly the result of human activity. All parts of the globe are potentially at risk. There are no activity sectors that will be left untouched. Adaptation is therefore necessary. Since 2006, the European Commission has been looking at the climate change adaptation issue. It first held a consultation on the European Commission Green Paper “adapting to climate change in Europe - options for EU action”. This led to the publication of the White Paper « Adapting to climate change: towards a European framework for action ». In this document, the EC puts forward the idea of a compulsory Adaptation Strategy at Member State level. Several EU countries have already done so: Finland, United Kingdom and France. Belgium, through the National Climate Commission, adopted its « National Climate Strategy » in late 2010. The objective is to recommend an operational action plan by 2012. This action plan will be the result of a merger between the action plans of the three regions and the federal governments. The Flemish region launched a study to start the development process of their action plan in 2010; the Walloon region has followed with this study and the Brussels region and the Federal should launch their studies during this year (2011). This study enabled to draw a complete review – characteristics, current vulnerabilities, future vulnerabilities - of the Walloon region on seven topics: Agriculture, water, infrastructure/ spatial planning, health, energy, biodiversity and forests. An enlarged experts’ consultation identified key measures to implement in order for Wallonia to adapt to climate change. Chapter 1, « climate change adaptation in European regions », is a stock-taking exercise of adaptation strategies found in Europe in order to draw relevant lessons for this study. Chapter 2: « the climate futures of Wallonia”, is an analysis of the climate projection specifically carried out for this study. Those projections were used to identify Wallonia’s vulnerabilities. Chapter 3 « Wallonia’s vulnerabilities to Climate change” explores the seven themes Agriculture, water, infrastructure/ spatial planning, health, energy, biodiversity and forests to describe the current and future risks and to put forward a time-dependent and sectoral hierarchy of impacts. Chapter 4 « Wallonia’s adaptation to climate change » states the core principles used to define the adaptation choices as well as the proposed guidelines for each theme. Chapter 5 « towards an action plan » presents the adaptation measures by theme along with the first elements of an evaluation procedure. Finally, the appendices contain the operational documents: the full thematic sheets, the action plan, the strategic guideline paper and the transversal analysis and the supporting documents: maps, climate projections database and the benchmarks. [less ▲]Detailed reference viewed: 67 (6 ULg)
Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC).
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in Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology (2010), 12(10), 1360-420Detailed reference viewed: 6 (0 ULg)
Climate control of terrestrial carbon exchange across biomes and continents
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in Environmental Research Letters (2010), 5(3),
Understanding the relationships between climate and carbon exchange by terrestrial ecosystems is critical to predict future levels of atmospheric carbon dioxide because of the potential accelerating ... [more ▼]
Understanding the relationships between climate and carbon exchange by terrestrial ecosystems is critical to predict future levels of atmospheric carbon dioxide because of the potential accelerating effects of positive climate-carbon cycle feedbacks. However, directly observed relationships between climate and terrestrial CO2 exchange with the atmosphere across biomes and continents are lacking. Here we present data describing the relationships between net ecosystem exchange of carbon (NEE) and climate factors as measured using the eddy covariance method at 125 unique sites in various ecosystems over six continents with a total of 559 site-years. We find that NEE observed at eddy covariance sites is (1) a strong function of mean annual temperature at mid-and high-latitudes, (2) a strong function of dryness at mid-and low-latitudes, and (3) a function of both temperature and dryness around the mid-latitudinal belt (45 degrees N). The sensitivity of NEE to mean annual temperature breaks down at similar to 16 degrees C (a threshold value of mean annual temperature), above which no further increase of CO2 uptake with temperature was observed and dryness influence overrules temperature influence. [less ▲]Detailed reference viewed: 114 (3 ULg)
HOW TO MAKE NATURA 2000 WORK PROPERLY? : SOCIO-ECONOMIC, LEGAL AND ECOLOGICAL MANAGEMENT : "SELNAT"
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This report includes results obtained from the SELNAT research project, conducted between February 2006 and January 2008, under the auspices of the Belgian Science Policy. The principal subject of this ... [more ▼]
This report includes results obtained from the SELNAT research project, conducted between February 2006 and January 2008, under the auspices of the Belgian Science Policy. The principal subject of this project is the implementation of Natura 2000. The Natura 2000 network of protected areas, made up of sites designated under the Community Birds (BD) and Habitats Directives (HD), is a key pillar of action for the conservation of biodiversity (European Commission, 2008). It is central to achieve the commitment to reverse the decline of biodiversity in the European Union by the year 2010 made at the European Council meeting in Gothenburg in June 2001. It aims at sustainable conservation of habitats and species of community importance, taking into account (i) economic, social and cultural requirements and (ii) regional and local circumstances. Central to the Directives is the creation of a Europe-wide ecological network of protected sites – the Natura 2000 Network – which is destined to conserve over a thousand rare, threatened and endemic species and some 220 Natural habitats listed in their annexes. Around 24,000 sites have been included in the Network so far. (European Commission, 2008) Now that the network set-up is nearing completion, there is a need to increase the focus on the active management of the sites so as to ensure long-term conservation and the achievement of the economic and social objectives of the network (CEE, 2004.) This in turn also raises the question of finding the appropriate management strategy, instruments and sufficient financing (at all levels). The principal question for Member States is how to manage Natura 2000 sites to reach the (juridical fixed) ecological targets in the most cost-efficient way, taking into account economic and social objectives and constraints. Ecologists and nature organisations often start from an techno-ecocentric paradigm: ‘How to conserve and manage species and habitats?’, in order to tackle the question mentioned above. The paradigm starts from the opinion that ‘diversity of species and habitats’ is important as such (while this is believed to be important for several reasons). This approach has been criticised lately for being based on a too narrow set of values. It has not provided enough opportunities for combining nature conservation with other forms of land use such as agriculture, forestry or tourism. In several countries this led to difficulties as regards the co-operation of local stakeholders (Jongman & Kristiansen, 1998). On the other hand, the current biodiversity crisis is a direct result of the way in which society has chosen to interact with its Natural environment. If the causes of the problem are social, it stands to reason that the policies striving to solve the problem will need to be based on a solid understanding of social structures and processes, if they are to have any effect. In this research project we tried to study the management of Natura 2000 sites from a ‘sustainability’ paradigm, instead of from the ecocentric paradigm. The central research question is therefore formulated as ‘How to manage Natura 2000 properly, to contribute to a (local) sustainable society?’ With this research we hope to give decision-makers new insights on the economic, social, and environmental consequences of Natura 2000 management and to guide them in the development of more adequate and sustainable policies for the management of Natura 2000-sites. In the first chapter the general objectives and approach of this project are described. The second chapter gives an overview of some of the current bottlenecks for nature conservation and Natura 2000. The results of the research on the elaboration of strategies for Natura 2000 sites are summarizes in chapter tree. Conclusions and recommendations are presented in the last chapter. More information on the research is documented in the different appendixes. During the research, we benefited from contacts with many persons, and more especially in the scope of a Users’ Committee. Besides the representatives of the Belgian Science Policy, we would like to thank all members of the Users’ Committee, among which those who supported us and/or participated in one or several of the meetings, [less ▲]Detailed reference viewed: 22 (0 ULg)
Glucocorticoids Modulate Tumor Radiation Response through a Decrease in Tumor Oxygen Consumption
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in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (2008), 15(13), 6305
Purpose: We hypothesized that glucocorticoids may enhance tumor radiosensitivity by increasing tumor oxygenation (pO2) through inhibition of mitochondrial respiration. Experimental Design: The effect of ... [more ▼]
Purpose: We hypothesized that glucocorticoids may enhance tumor radiosensitivity by increasing tumor oxygenation (pO2) through inhibition of mitochondrial respiration. Experimental Design: The effect of three glucocorticoids (hydrocortisone, dexamethasone, and prednisolone) on pO2 was studied in murine TLT liver tumors and FSaII fibrosarcomas. At the time of maximum pO2 (tmax, 30 min after administration), perfusion, oxygen consumption, and radiation sensitivity were studied. Local pO2 measurements were done using electron paramagnetic resonance. The oxygen consumption rate of tumor cells after in vivo glucocorticoid administration was measured using high-frequency electron paramagnetic resonance. Tumor perfusion and permeability measurements were assessed by dynamic contrast-enhanced magnetic resonance imaging. Results: All glucocorticoids tested caused a rapid increase in pO2. At tmax, tumor perfusion decreased, indicating that the increase in pO2 was not caused by an increase in oxygen supply. Also at tmax, global oxygen consumption decreased. When irradiation (25 Gy) was applied at tmax, the tumor radiosensitivity was enhanced (regrowth delay increased by a factor of 1.7). Conclusion: These results show the potential usefulness of the administration of glucocorticoids before irradiation. [less ▲]Detailed reference viewed: 16 (2 ULg)
The Chlamydomonas genome reveals the evolution of key animal and plant functions.
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in Science (2007), 318(5848), 245-50
Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the ... [more ▼]
Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited from the common ancestor of plants and animals, but lost in land plants. We sequenced the approximately 120-megabase nuclear genome of Chlamydomonas and performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated with the function and biogenesis of chloroplasts or eukaryotic flagella. Analyses of the Chlamydomonas genome advance our understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella. [less ▲]Detailed reference viewed: 68 (18 ULg)