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Manos-Turvey Alexandra

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Main Referenced Co-authors
Payne, Richard J. (6)
Baker, Edward N. (5)
Lott, J. Shaun (5)
Bulloch, Esther M. M. (4)
Brodsky, Jeffrey L. (3)
Main Referenced Keywords
Alzheimer's disease (1); AMPA (1); antibiotics chorismate-utilizing enzymes medicinal chemistry Mycobacterium tuberculosis salicylate synthase (1); Biginelli (1); BKPyV (1);
Main Referenced Unit & Research Centers
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège [BE] (1)
Main Referenced Disciplines
Chemistry (20)
Biochemistry, biophysics & molecular biology (14)
Pharmacy, pharmacology & toxicology (4)
Life sciences: Multidisciplinary, general & others (3)
Immunology & infectious disease (1)

Publications (total 24)

The most cited

48 citations (Scopus®)

Manos-Turvey, A., Bulloch, E. M. M., Rutledge, P. J., Baker, E. N., Lott, J. S., & Payne, R. J. (2010). Inhibition Studies of Mycobacterium tuberculosis Salicylate Synthase (MbtI). ChemMedChem, 5 (7), 1067-1079. doi:10.1002/cmdc.201000137 https://hdl.handle.net/2268/197854

Manos-Turvey, A. (2017). The Synthesis and Evaluation of [18F]BPAM121: Potential of an AMPA Receptor Positive Allosteric Modulator [Paper presentation]. The 31st Journées Franco-Belges de Pharmacochimie, Spa, Belgium.

Manos-Turvey, A., Lemaire, C., Becker, G., Plenevaux, A., Luxen, A., Pirotte, B., & Francotte, P. (August 2017). Design and Synthesis of [18F]BPAM121, a PET-Probe Targeting AMPA-subtype Glutamatergic Receptors [Poster presentation]. EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry, Vienne, Austria.

Manos-Turvey, A., Lemaire, C., Becker, G., Plenevaux, A., Luxen, A., Francotte, P., & Pirotte, B. (July 2017). Synthesis of [18F]BPAM121: An AMPAR Modulator with Potential as a PET Probe [Poster presentation]. RICT 2017, Drug Discovery and Selection, 53rd International Conference on Medicinal Chemistry, Toulouse, France.

Manos-Turvey, A., Lemaire, C., Deverdenne, F., Luxen, A., Francotte, P., & Pirotte, B. (June 2017). [18F]BPAM121: An AMPAR Modulator with Potential as a PET Probe [Poster presentation]. Royal Society of Chemistry Medicinal Chemistry Residential School, Loughborough, United Kingdom.

Manos-Turvey, A. (2016). Toward Characterisation of the Potential of an AMPAR Modulator as a PET Probe [Poster presentation]. MedChem 2016, Annual Meeting on Medicinal Chemistry of SRC & KVCV, Mont-Saint-Guibert, Belgium.

Manos-Turvey, A. (2016). Characterisation of the Pharmacological Action of a Series of AMPAR Modulators using a PET Probe [Poster presentation]. The 6th European Workshop in Drug Synthesis (VI EWDSy), Siena, Italy.

Manos-Turvey, A. (2016). Toward the Characterisation of the Pharmacological Action of a Series of AMPAR Modulators using a PET Probe [Poster presentation]. The 52nd International Conference on Medicinal Chemistry (RICT 2016), Caen, France.

Manos-Turvey, A., Brodsky, J. L., Wipf, P., McAlpine, R. S., & Edkins, L. A. (2016). The Effect of Structure and Mechanism of the Hsp70 Chaperone on the Ability to Identify Chemical Modulators and Therapeutics. In Heat Shock Protein Inhibitors: Success Stories (pp. 81-129). Cham, Germany: Springer International Publishing. doi:10.1007/7355_2015_90
Peer reviewed

Manos-Turvey, A. (2016). Rational Design Towards the First Class of Positive Allosteric Modulators of Kainate Receptors [Poster presentation]. EFMC-ISMC 24th International Symposium on Medicinal Chemistry, Manchester, United Kingdom.

Manos-Turvey, A., Al-Ashtal, H. A., Needham, P. G., Hartline, C. B., Prichard, M. N., Wipf, P., & Brodsky, J. L. (2016). Dihydropyrimidinones and -thiones with improved activity against human polyomavirus family members. Bioorganic and Medicinal Chemistry Letters, 26 (20), 5087-5091. doi:10.1016/j.bmcl.2016.08.080
Peer Reviewed verified by ORBi

Manos-Turvey, A., Watson, E. E., Sykes, M. L., Jones, A. J., Baell, J. B., Kaiser, M., Avery, V. M., & Payne, R. J. (2015). Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents. MedChemComm, 6 (3), 403-406. doi:10.1039/C4MD00406J
Peer Reviewed verified by ORBi

Bashiri, G., Johnston, J. M., Evans, G. L., Bulloch, E. M. M., Goldstone, D. C., Jirgis, E. N. M., Kleinboelting, S., Castell, A., Ramsay, R. J., Manos-Turvey, A., Payne, R. J., Lott, J. S., & Baker, E. N. (2015). Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex. Acta Crystallographica. Section D, Biological Crystallography, 71 (11), 2297-2308. doi:10.1107/S1399004715017216
Peer Reviewed verified by ORBi

Ireland, A. W., Gobillot, T. A., Gupta, T., Seguin, S. P., Liang, M., Resnick, L., Goldberg, M. T., Manos-Turvey, A., Pipas, J. M., Wipf, P., & Brodsky, J. L. (2014). Synthesis and structure–activity relationships of small molecule inhibitors of the simian virus 40 T antigen oncoprotein, an anti-polyomaviral target. Bioorganic and Medicinal Chemistry, 22 (22), 6490-6502. doi:10.1016/j.bmc.2014.09.019
Peer Reviewed verified by ORBi

Manos-Turvey, A. (2014). Inhibition of the Hsp70 Molecule Chaperone Differentially Affects the Survival of Distinct Rhabdomyosarcoma Cell Lines [Poster presentation]. The 26th University of Pittsburgh Cancer Institute Scientific Retreat, Greensburg, PA, United States.

Manos-Turvey, A. (2013). A Multi-Pronged Approach Toward Neglected Disease Drug Discovery [Doctoral thesis, University of Sydney]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/197856

Manos-Turvey, A., Cergol, K. M., Salam, N. K., Bulloch, E. M. M., Chi, G., Pang, A., Britton, W. J., West, N. P., Baker, E. N., Lott, J. S., & Payne, R. J. (2012). Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site. Organic and Biomolecular Chemistry, 10 (46), 9223-9236. doi:10.1039/C2OB26736E
Peer Reviewed verified by ORBi

Chi, G., Manos-Turvey, A., O’Connor, P. D., Johnston, J. M., Evans, G. L., Baker, E. N., Payne, R. J., Lott, J. S., & Bulloch, E. M. M. (2012). Implications of Binding Mode and Active Site Flexibility for Inhibitor Potency against the Salicylate Synthase from Mycobacterium tuberculosis. Biochemistry, 51 (24), 4868-4879. doi:10.1021/bi3002067
Peer Reviewed verified by ORBi

Manos-Turvey, A. (2012). Investigation of Salicylate Synthase Inhibitors as Tuberculosis Drugs Leads [Paper presentation]. RACI Division of Biomolecular Chemistry One-Day Symposium, Sydney, Australia.

Manos-Turvey, A. (2012). Investigation of a Novel Inhibitor Binding Conformation of Salicylate Synthase Inhibitors in Anti-Tubercular Drugs Discovery [Poster presentation]. The 19th International Conference on Organic Synthesis (ICOS19), Melbourne, Australia.

Manos-Turvey, A. (2011). Synthesis and Evaluation of Salicylate Synthase Inhibitors as Tuberculosis Drugs Leads [Poster presentation]. RACI Biomolecular Division Conference ‘Biomolecular at the Beach', Victoria, Australia.

Chim, N., Habel, J. E., Johnston, J. M., Krieger, I., Miallau, L., Sankaranarayanan, R., Morse, R. P., Bruning, J., Swanson, S., Kim, H., Kim, C.-Y., Li, H., Bulloch, E. M., Payne, R. J., Manos-Turvey, A., Hung, L.-W., Baker, E. N., Lott, J. S., James, M. N. G., ... Goulding, C. W. (2011). The TB Structural Genomics Consortium: A decade of progress. Tuberculosis, 91 (2), 155-172. doi:10.1016/j.tube.2010.11.009
Peer Reviewed verified by ORBi

Manos-Turvey, A. (2011). Synthesis and Evaluation of Salicylate Synthase (MbtI) Inhibitors as Tuberculosis Drug Leads [Poster presentation]. The 17th European Symposium on Organic Chemistry (ESOC 2011), Crete, Greece.

Manos-Turvey, A., Bulloch, E. M. M., Rutledge, P. J., Baker, E. N., Lott, J. S., & Payne, R. J. (2010). Inhibition Studies of Mycobacterium tuberculosis Salicylate Synthase (MbtI). ChemMedChem, 5 (7), 1067-1079. doi:10.1002/cmdc.201000137
Peer Reviewed verified by ORBi

Manos-Turvey, A. (2010). Synthesis and Evaluation of Salicylate Synthase (MbtI) Inhibitors as Tuberculosis Drug Leads [Poster presentation]. EFMC-ISMC 21st International Symposium on Medicinal Chemistry, Brussels, Belgium.

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